keyword
MENU ▼
Read by QxMD icon Read
search

Tie2

keyword
https://www.readbyqxmd.com/read/29154961/inhibition-of-cyclooxygenase-cox-2-suppresses-the-recruitment-of-endothelial-progenitor-cells-in-the-microvasculature-of-endometriotic-lesions
#1
Jeannette Rudzitis-Auth, Ruth M Nickels, Michael D Menger, Matthias W Laschke
The incorporation of endothelial progenitor cells (EPCs) into newly developing blood vessels contributes to the vascularization of endometriotic lesions. here, we analyzed whether cyclooxygenase (COX)-2 signaling regulates this vasculogenic process. Endometriotic lesions were surgically induced in irradiated FVB/N mice, which were reconstituted with bone marrow from FVB/N-TgN (Tie2/green fluorescent protein (GFP)) 287 Sato mice. The animals received β-estradiol 17-valerate once a week and were daily treated with the selective COX-2 inhibitor parecoxib (25 mg/kg) or vehicle (control) over 7 and 28 days...
November 15, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29149941/pathophysiology-of-septic-shock
#2
REVIEW
James A Russell, Barret Rush, John Boyd
Fundamental features of septic shock are vasodilation, increased permeability, hypovolemia, and ventricular dysfunction. Vasodilation owing to increased nitric oxide and prostaglandins is treated with vasopressors (norepinephrine first). Increased permeability relates to several pathways (Slit/Robo4, vascular endothelial growth factor, angiopoietin 1 and 2/Tie2 pathway, sphingosine-1-phosphate, and heparin-binding protein), some of which are targets for therapies. Hypovolemia is common and crystalloid is recommended for fluid resuscitation...
January 2018: Critical Care Clinics
https://www.readbyqxmd.com/read/29132435/vasculotide-reduces-pulmonary-hyperpermeability-in-experimental-pneumococcal-pneumonia
#3
Birgitt Gutbier, Xiaohui Jiang, Kristina Dietert, Carolin Ehrler, Jasmin Lienau, Paul Van Slyke, Harold Kim, Van C Hoang, Jason T Maynes, Daniel J Dumont, Achim D Gruber, Norbert Weissmann, Timothy J Mitchell, Norbert Suttorp, Martin Witzenrath
BACKGROUND: Community-acquired pneumonia (CAP) is a significant cause of morbidity and mortality worldwide. Despite effective antimicrobial therapy, CAP can induce pulmonary endothelial hyperpermeability resulting in life-threatening lung failure due to an exaggerated host-pathogen interaction. Treatment of acute lung injury is mainly supportive because key elements of inflammation-induced barrier disruption remain undetermined. Angiopoietin-1 (Ang-1)-mediated Tie2 activation reduces, and the Ang-1 antagonist Ang-2 increases, inflammation and endothelial permeability in sepsis...
November 13, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29125991/effects-of-quercetin-combined-with-anticancer-drugs-on-metastasis-associated-factors-of-gastric-cancer-cells-in-vitro-and-in-vivo-studies
#4
Cing-Syuan Lei, Yu-Chen Hou, Man-Hui Pai, Ming-Tsan Lin, Sung-Ling Yeh
Chemotherapy is essential to most patients with gastric cancer and the anticancer drug, irinotecan (CPT-11), and its metabolite, SN-38, an inhibitor of DNA topoisomerase I, are first-line chemotherapies for gastric cancer. Quercetin, a flavonoid that is widely found in various vegetables and fruits, has the ability to potentiate the efficacy of anticancer drugs. The purpose of this study was to investigate the therapeutic effect of quercetin combined with irinotecan/SN-38 in the AGS human gastric cancer cell line in vitro and in vivo...
September 28, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29115538/complementary-actions-of-melatonin-on-angiogenic-factors-the-angiopoietin-tie2-axis-and-vegf-in-co%C3%A2-cultures-of-human-endothelial-and-breast-cancer-cells
#5
Alicia González-González, Alicia González, Carolina Alonso-González, Javier Menéndez-Menéndez, Carlos Martínez-Campa, Samuel Cos
Melatonin exerts oncostatic activity in breast cancer through antiangiogenic actions. There, the aim of the present study was to ascertain whether melatonin modulates, in a coordinated action, angiopoietin-1 (ANG-1), ANG-2, their cognate Tie2 receptor and VEGF in co-cultures of human endothelial cells (HUVECs) and breast cancer (MCF-7) cells. To accomplish this we used co-cultures of human breast cancer cells (MCF-7) or non-malignant human mammary epithelial cells (MCF‑10A) with endothelial cells (HUVECs)...
November 2, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29101349/t-cells-upon-activation-promote-endothelin-1-production-in-monocytes-via-ifn-%C3%AE-and-tnf-%C3%AE
#6
Shoshi Shinagawa, Takahiro Okazaki, Mari Ikeda, Kazuo Yudoh, Yaz Y Kisanuki, Masashi Yanagisawa, Kimito Kawahata, Shoichi Ozaki
Endothelin 1 (ET-1), mainly produced from vascular endothelial cells, induces vasoconstriction in physiological conditions. The endothelin receptor antagonist is among the most effective agents for pulmonary hypertension. However, little is known about the production source of ET-1 in inflammation and immunity. Here, we studied whether T cell-mediated ET-1 production system exists and operates independent of the production system in vascular endothelial cells. ET-1 production was readily detectable in the culture supernatant of human PBMCs and murine spleen cells stimulated with anti-CD3 antibody...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29057961/pannexin1-links-lymphatic-function-to-lipid-metabolism-and-atherosclerosis
#7
Filippo Molica, Merlijn J Meens, Juan Dubrot, Avigail Ehrlich, Christel L Roth, Sandrine Morel, Graziano Pelli, Laurent Vinet, Vincent Braunersreuther, Osman Ratib, Marc Chanson, Stephanie Hugues, Eliana Scemes, Brenda R Kwak
Extracellular ATP is a central signaling molecule in inflammatory responses. Pannexin1 (Panx1) channels release ATP in a controlled manner and have been implicated in various inflammatory pathologies, but their role in atherogenesis remains elusive. Using atherosclerosis-susceptible mouse models with ubiquitous deletion of Panx1 (Panx1 (-/-) Apoe (-/-) ) or with Cre recombinase-mediated deletion of Panx1 in endothelial cells and monocytes (Tie2-Cre (Tg) Panx1 (fl/fl) Apoe (-/-) ; Panx1 (del) Apoe (-/-) ), we identified a novel role for Panx1 in the lymphatic vasculature...
October 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29046873/embryonic-stem-cell-like-subpopulations-in-venous-malformation
#8
Elysia M S Tan, Sam Duro Siljee, Helen D Brasch, Susana Enriquez, Swee T Tan, Tinte Itinteang
BACKGROUND: Venous malformation (VM) consists of a network of ectatic anomalous thin-walled venous channels. A role for an activating TIE2 mutation in the development of the dilated luminal vessels in VM, and its proposed involvement of embryonic stem cells (ESCs), led us to investigate the expression of ESC markers in subcutaneous VM (SCVM) and intramuscular VM (IMVM). METHODS: Formalin-fixed paraffin-embedded sections of SCVM from seven patients and IMVM samples from seven patients were analyzed for the expression of Nanog, pSTAT3, OCT4, SOX2, SALL4, and CD44, using 3,3'-diaminobenzidine (DAB) immunohistochemical (IHC) staining...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29023576/overexpression-of-tissue-nonspecific-alkaline-phosphatase-tnap-in-endothelial-cells-accelerates-coronary-artery-disease-in-a-mouse-model-of-familial-hypercholesterolemia
#9
Filippo Romanelli, AnthonyMarco Corbo, Maryam Salehi, Manisha C Yadav, Soha Salman, David Petrosian, Omid J Rashidbaigi, Jesse Chait, Jes Kuruvilla, Maria Plummer, Ilian Radichev, Kenneth B Margulies, A Martin Gerdes, Anthony B Pinkerton, José Luis Millán, Alexei Y Savinov, Olga V Savinova
OBJECTIVE: Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelium leads to arterial calcification in mice. The purpose of this study was to examine the effect of elevated endothelial TNAP on coronary atherosclerosis. In addition, we aimed to examine endogenous TNAP activity in human myocardium. APPROACH AND RESULTS: A vascular pattern of TNAP activity was observed in human non-failing, ischemic, and idiopathic dilated hearts (5 per group); no differences were noted between groups in this study...
2017: PloS One
https://www.readbyqxmd.com/read/29016745/cxcl12-cxcr4-signalling-plays-an-essential-role-in-proper-patterning-of-aortic-arch-and-pulmonary-arteries
#10
Bo-Gyeong Kim, Yong Hwan Kim, Edward L Stanley, Eva M Garrido-Martin, Young Jae Lee, S Paul Oh
Aims: Chemokine CXCL12 (stromal derived factor 1: SDF1) has been shown to play important roles in various processes of cardiovascular development. In recent avian studies, CXCL12 signalling has been implicated in guidance of cardiac neural crest cells for their participation in the development of outflow tract and cardiac septum. The goal of this study is to investigate the extent to which CXCL12 signalling contribute to the development of aortic arch and pulmonary arteries in mammals...
November 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28992234/pharmacologic-management-of-diabetic-retinopathy
#11
Akiyoshi Uemura
Diabetic retinopathy (DR) is a leading cause of vision loss in working-age populations, primarily attributable to retinal vascular hyperpermeability, hypoperfusion, and neoangiogenesis. In the past decade, laser photocoagulation and surgical interventions to treat DR have been replaced by topical administrations of anti-vascular endothelial growth factor drugs and corticosteroids. Although these drugs have revolutionized clinical management of DR, their limited efficacy and adverse effects have raised an increasing demand for new drug development...
September 6, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28968277/vasculotide-an-angiopoietin-1-mimetic-restores-microcirculatory-perfusion-and-microvascular-leakage-and-decreases-fluid-resuscitation-requirements-in-hemorrhagic-shock
#12
Michelle Trieu, Matijs van Meurs, Anoek L I van Leeuwen, Paul Van Slyke, Van Hoang, Leo M G Geeraedts, Christa Boer, Charissa E van den Brom
BACKGROUND: Microcirculatory dysfunction is associated with multiple organ failure and unfavorable patient outcome. We investigated whether therapeutically targeting the endothelial angiopoietin/Tie2 system preserves microvascular integrity during hemorrhagic shock. METHODS: Rats were treated with the angiopoietin-1 mimetic Vasculotide and subjected to hemorrhagic shock and fluid resuscitation. Microcirculatory perfusion and leakage were assessed with intravital microscopy (n = 7 per group) and Evans blue dye extravasation (n = 8 per group), respectively...
September 29, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28951241/protection-from-psoriasis-related-thrombosis-following-inhibition-of-il-23-or-il-17a
#13
Yumeng Li, Jackelyn B Golden, Maya I Camhi, Xiufen Zhang, Yi Fritz, Doina Diaconu, Tammy L Ivanco, Daniel I Simon, Kristine Kikly, Thomas S McCormick, Yunmei Wang, Nicole L Ward
Psoriasis patients experience chronic systemic skin inflammation and develop cardiovascular comorbidities that shorten their lifespan. Whether cardiovascular disease is improved by treatment with current biologics that target disease-specific pathways is unclear. KC-Tie2 mice develop psoriasiform skin inflammation with increases in IL-23 and IL-17A and proinflammatory monocytosis and neutrophilia that precedes development of carotid artery thrombus formation. To examine whether targeted blockade of IL-23 or IL-17A in KC-Tie2 psoriasis mice improves cardiovascular outcomes, mice were treated systemically for 6 weeks with antibodies targeting IL-17A, IL-17RA, IL-12/23p40, or IL-23p19...
September 23, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28950253/transthyretin-exerts-pro-apoptotic-effects-in-human-retinal-microvascular-endothelial-cells-through-a-grp78-dependent-pathway-in-diabetic-retinopathy
#14
Jun Shao, Ying Yin, Xiaowen Yin, Li Ji, Yu Xin, Jian Zou, Yong Yao
BACKGROUND/AIMS: Diabetic retinopathy (DR) is one of the main causes of blindness in the world. Our previous study showed that transthyretin (TTR) regulates key genes in the Tie2 pathway and inhibits the development of neovascularization in DR, but the mechanism is still unclear. Here, we investigated how TTR affects the progression of neovascularization in DR. METHODS: Natural and simulated DR media (hyperglycemia and hypoxia) were used to culture human retinal microvascular endothelial cells (hRECs)...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28944168/normalizing-tumoral-vessels-to-treat-cancer-an-out-of-the-box-strategy-involving-tie2-pathway
#15
Juan Fueyo, Mohammad B Hossain, Teresa Nguyen, Candelaria Gomez-Manzano
No abstract text is available yet for this article.
March 2017: Translational Cancer Research
https://www.readbyqxmd.com/read/28926234/using-ultra-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-based-chemometrics-for-the-identification-of-anti-angiogenic-biflavonoids-from-edible-garcinia-species
#16
Ping Li, Grace Gar-Lee Yue, Hin-Fai Kwok, Chun-Lin Long, Clara Bik-San Lau, Edward J Kennelly
Garcinia xanthochymus fruits are edible and also used in traditional medicine. Our previous work showed that the isolated natural products from G. xanthochymus fruits have displayed antioxidant activity and cytotoxicity in the colon cancer cells. In this study, we developed a strategy to correlate a zebrafish angiogenesis assay with ultra-performance liquid chromatography quadrupole time of flight mass spectrometry-based chemometric analysis to identify potential anti-angiogenic activity compounds from G. xanthochymus fruits...
September 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28920924/impaired-angiopoietin-tie2-signaling-compromises-schlemm-s-canal-integrity-and-induces-glaucoma
#17
Jaeryung Kim, Dae-Young Park, Hosung Bae, Do Young Park, Dongkyu Kim, Choong-Kun Lee, Sukhyun Song, Tae-Young Chung, Dong Hui Lim, Yoshiaki Kubota, Young-Kwon Hong, Yulong He, Hellmut G Augustin, Guillermo Oliver, Gou Young Koh
Primary open-angle glaucoma (POAG) is often caused by elevated intraocular pressure (IOP), which arises due to increased resistance to aqueous humor outflow (AHO). Aqueous humor flows through Schlemm's canal (SC), a lymphatic-like vessel encircling the cornea, and via intercellular spaces of ciliary muscle cells. However, the mechanisms underlying increased AHO resistance are poorly understood. Here, we demonstrate that signaling between angiopoietin (Angpt) and the Angpt receptor Tie2, which is critical for SC formation, is also indispensable for maintaining SC integrity during adulthood...
October 2, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28920923/all-tied-up-mechanisms-of-schlemm-s-canal-maintenance
#18
Jeremiah Bernier-Latmani, Tatiana V Petrova
Glaucoma is a leading cause of blindness, with an estimated world-wide prevalence of 3.5% in members of the population older than 40 years of age. Elevated intraocular pressure as the result of abnormal resistance to aqueous humor drainage is a major contributing, and the only preventable, factor in glaucoma development. Schlemm's canal (SC), a lymphatic-like vessel encircling the anterior portion of the eye, plays a key role in promoting aqueous humor outflow and maintenance of normal intraocular pressure...
October 2, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28915606/proteolytic-cleavages-in-the-extracellular-domain-of-receptor-tyrosine-kinases-by-membrane-associated-serine-proteases
#19
Li-Mei Chen, Karl X Chai
The epithelial extracellular membrane-associated serine proteases matriptase, hepsin, and prostasin are proteolytic modifying enzymes of the extracellular domain (ECD) of the epidermal growth factor receptor (EGFR). Matriptase also cleaves the ECD of the vascular endothelial growth factor receptor 2 (VEGFR2) and the angiopoietin receptor Tie2. In this study we tested the hypothesis that these serine proteases may cleave the ECD of additional receptor tyrosine kinases (RTKs). We co-expressed the proteases in an epithelial cell line with Her2, Her3, Her4, insulin receptor (INSR), insulin-like growth factor I receptor (IGF-1R), the platelet-derived growth factor receptors (PDGFRs) α and β, or nerve growth factor receptor A (TrkA)...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915063/twist1-in-hypoxia-induced-pulmonary-hypertension-through-tgf%C3%AE-smad-signaling
#20
Tadanori Mammoto, Megan Muyleart, G Ganesh Konduri, Akiko Mammoto
Pulmonary hypertension (PH) is a devastating pulmonary vascular disease characterized by aberrant muscularization of the normally non-muscularized distal pulmonary arterioles. The expression of the transcription factor, Twist1, increases in the lungs of pulmonary arterial hypertension patients. However, the mechanisms by which Twist1 controls the pathogenesis of PH remain unclear. It is becoming clear that endothelial-to-mesenchymal transition (EndMT) contributes to various vascular pathologies including PH; Twist1 is known to mediate EndMT...
September 15, 2017: American Journal of Respiratory Cell and Molecular Biology
keyword
keyword
65390
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"