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https://www.readbyqxmd.com/read/29223109/genome-wide-analysis-of-barrett-s-adenocarcinoma-a-first-step-towards-identifying-patients-at-risk-and-developing-therapeutic-paths
#1
Yiyang Dai, Qing Wang, Adrian Gonzalez Lopez, Mario Anders, Peter Malfertheiner, Michael Vieth, Wolfgang Kemmner
BACKGROUND: Barrett's esophagus metaplasia is the key precursor lesion of esophageal adenocarcinoma. The aim of this study was to find a subset of markers that may allow the identification of patients at risk for esophageal adenocarcinoma, and to determine genes differentially expressed in esophageal squamous cell carcinoma. METHODS: Laser capture microdissection technique was applied to procure cells from defined regions. Genome-wide RNA profiling was performed on esophageal adenocarcinoma (n = 21), Barrett's esophagus (n = 20), esophageal squamous carcinoma (n = 9) and healthy esophageal biopsies (n = 18) using the Affymetrix Human Genome U133plus 2...
December 6, 2017: Translational Oncology
https://www.readbyqxmd.com/read/29203358/dietary-fish-oil-supplementation-enhances-expression-of-genes-involved-in-cornified-cell-envelope-formation-in-rat-skin
#2
Peiru Wang, Min Sun, Jianwei Ren, Muhammad Nadeem Aslam, Yuting Xu, Gary J Fisher, John J Voorhees, Xiuli Wang, Yong Li
No abstract text is available yet for this article.
December 1, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29183759/phosphodiesterase-4b-plays-a-role-in-benzophenone-3-induced-phototoxicity-in-normal-human-keratinocytes
#3
Hyoung-June Kim, Eunyoung Lee, Moonyoung Lee, Sungjin Ahn, Jungmin Kim, Jingjing Liu, Sun Hee Jin, Jaehyoun Ha, Il Hong Bae, Tae Ryong Lee, Minsoo Noh
Benzophenone-3 (BP-3), which is extensively used in organic sunscreen, has phototoxic potential in human skin. Phosphodiesterase 4B (PDE4B) has a well-established role in inflammatory responses in immune cells. Currently, it is unknown if PDE4B is associated with BP-3-induced phototoxicity in normal human keratinocytes (NHKs). We found that BP-3 significantly increased PDE4B expression in ultraviolet B (UVB)-irradiated NHKs. Notably, BP-8, a sunscreen agent that shares the 2-hydroxy-4-methoxyphenyl methanone moiety with BP-3, also upregulated PDE4B expression in NHKs...
November 25, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29168893/oral-tolerance-modulates-the-skin-transcriptome-in-mice-with-induced-atopic-dermatitis
#4
Jin Ok Baek, Jong Rok Lee, Joo Young Roh, YunJae Jung
Defective gut immune reactions have been implicated in the development of atopic dermatitis (AD), whereas oral tolerance (OT), i.e., the immune unresponsiveness induced by oral antigen administration, protects mice against AD. To investigate this protective role of OT, the transcriptomic profiles of skin were obtained by RNA sequencing from mice that were epicutaneously sensitized, orally tolerized prior to epicutaneous sensitization, or neither (control). OT inhibited the upregulation of keratin- and allergic inflammation-associated genes that occurred in the epicutaneously sensitized group...
November 23, 2017: Allergy
https://www.readbyqxmd.com/read/29153780/barrier-dysfunction-in-the-skin-allergy
#5
REVIEW
Gyohei Egawa, Kenji Kabashima
The skin is continuously exposed to external pathogens, and its barrier function is critical for skin homeostasis. Previous studies have shown that the barrier dysfunction is one of the most predisposing factors for the development of skin allergic diseases such as atopic dermatitis. In this article, we summarize how the physical barrier of the skin is organized and review its link to the pathomechanism of skin allergic diseases. We describe the formation of the SC barrier in terms of the following five categories: 1) filaggrin metabolism; 2) cornified envelope; 3) intercellular lipids; 4) corneodesmosome; and 5) corneocyte desquamation...
November 16, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29113187/overexpression-of-tumor-suppressor-gene-znf750-inhibits-oral-squamous-cell-carcinoma-metastasis
#6
Hongli Yang, Li Pan, Cong Xu, Yingxin Zhang, Keyi Li, Shuangfeng Chen, Bin Zhang, Zhijun Liu, Le-Xin Wang, Haiying Chen
Zinc-finger protein 750 (ZNF750) encodes a putative C2H2 zinc finger protein and is typically mutated or deleted in squamous cell carcinoma. The role of ZNF750 in oral squamous cell carcinoma (OSCC) remains unknown. The aim of the present study was to investigate the effects of ZNF750 overexpression in CAL-27 cells. Cell viability, and the expression of genes associated with proliferation, differentiation and the epithelial-mesenchymal transition were investigated in CAL-27 cells following ZNF750 overexpression, using Cell Counting kit-8, reverse transcription-quantitative polymerase chain reaction and western blot analysis, respectively...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29072680/transglutaminase-2-mediates-uv-induced-skin-inflammation-by-enhancing-inflammatory-cytokine-production
#7
Seok-Jin Lee, Ki Baek Lee, Young Hoon Son, Jiwoong Shin, Jin-Haeng Lee, Hyo-Jun Kim, Ah-Young Hong, Hee Won Bae, Mee-Ae Kwon, Won Jong Lee, Jin-Hee Kim, Dong Hun Lee, Eui Man Jeong, In-Gyu Kim
UV irradiation elicits acute inflammation in the skin by increasing proinflammatory cytokine production in keratinocytes. However, the downstream protein target(s) that link UV radiation to the activation of signaling pathways responsible for cytokine expression have not been fully elucidated. In this study, we report a novel role of transglutaminase 2 (TG2), a member of the TG enzyme family whose activities are critical for cornified envelope formation, in mediating UV-induced inflammation. Our results showed that TG2-deficient mice exhibited reduced inflammatory responses to UV irradiation, including reduced erythema, edema, dilation of blood vessels, inflammatory cell infiltration, and levels of inflammatory cytokines...
October 26, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29055413/pushing-the-envelope-in-psoriasis-late-cornified-envelope-proteins-possess-antimicrobial-activity
#8
Nathan K Archer, Migena N Dilolli, Lloyd S Miller
Deletion of late cornified envelope (LCE) genes LCE3B and LCE3C (LCE3B/C-del) is a psoriasis risk factor linked to the major psoriasis risk gene HLA-C*06. Niehues et al. demonstrate that LCE3B/C-del leads to increased keratinocyte LCE3A expression. They also show that LCE3A/B/C possess antimicrobial activity but do not obviously regulate epidermal barrier integrity. These findings implicate LCE proteins in psoriasis pathogenesis via a new functional role.
November 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28936777/phytosphingosine-enhances-moisture-level-in-human-skin-barrier-through-stimulation-of-the-filaggrin-biosynthesis-and-degradation-leading-to-nmf-formation
#9
Hyun Kyung Choi, Young Hoon Cho, Eun Ok Lee, Jin Wook Kim, Chang Seo Park
Phytosphingosine (PHS) is a sphingoid that is a key component of phytoceramides NP, AP and EOP. PHS has been known to have anti-inflammation and antimicrobial activities and to stimulate epidermal differentiation. In addition, it is reported that PHS treatment notably increased phytoceramide content in keratinocytes. In this study, we tried to investigate whether PHS has any effect on the maturation of corneocytes such as formation of cornified envelope and natural moisturizing factor (NMF) that is also an essential event during the formation of skin barrier, stratum corneum...
September 21, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28928893/the-epigenetic-regulation-of-cxcl14-plays-a-role-in-the-pathobiology-of-oral-cancers
#10
Ryuji Nakayama, Kazumune Arikawa, Ujjal K Bhawal
Background: Chemokines selectively attract and activate leukocytes and play roles in a variety of homeostatic and disease processes. Explore the biological properties of CXCL14 seems complicated due to unknown functional characteristics of CXCL14 in cancer. Methods: To study the multistep process of oral cancer development, we analyzed oral samples spanning normalcy, dysplasia and cancer from multiple perspectives, revealing a cascade of progressive changes. Results: CXCL14 protein was expressed in the cytoplasm adjacent to tumors...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28865110/the-effect-of-photodamage-on-the-female-caucasian-facial-stratum-corneum-corneome-using-mass-spectrometry-based-proteomics
#11
R Voegeli, J-M Monneuse, R Schoop, B Summers, A V Rawlings
BACKGROUND: The effect of photodamage on facial stratum corneum (SC) is still poorly understood. OBJECTIVE: To describe the SC proteome from tape strippings of Caucasian SC from photoexposed cheek and photoprotected post-auricular (PA) site, a global analysis of photodamage on the skin will be developed leading to a better understanding of keratinocyte signalling pathways and identification of new molecular targets for the treatment of photoaged skin. METHODS: Female Caucasian subjects had nine consecutive tape strippings taken from their cheeks and PA site...
September 2, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28796650/using-skin-gene-markers-for-estimating-early-postmortem-interval-at-different-temperatures
#12
Mona Mohamed Ali, Samah Fathy Ibrahim, Amel Ahmed Fayed
Many researches document long-term RNA persistence in a variety of tissues and its applicability in estimating the postmortem interval (PMI). Skin-specific mRNA marker, late cornified envelope 1C (LCE1C), was used to identified skin samples. Before using the LCE1C in criminal casework, its persistence and applicability for estimating PMI in different temperatures were tested. Twelve skin samples were collected from 6 patients, and 6 samples were kept at 24°C and others were kept at 40°C for 5 days. The expression levels of LCE1C mRNA are serially detected and quantified using real-time polymerase chain reaction...
December 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28634035/psoriasis-associated-late-cornified-envelope-lce-proteins-have-antibacterial%C3%A2-activity
#13
Hanna Niehues, Lam C Tsoi, Danique A van der Krieken, Patrick A M Jansen, Merel A W Oortveld, Diana Rodijk-Olthuis, Ivonne M J J van Vlijmen, Wiljan J A J Hendriks, Richard W Helder, Joke A Bouwstra, Ellen H van den Bogaard, Philip E Stuart, Rajan P Nair, James T Elder, Patrick L J M Zeeuwen, Joost Schalkwijk
Terminally differentiating epidermal keratinocytes express a large number of structural and antimicrobial proteins that are involved in the physical barrier function of the stratum corneum and provide innate cutaneous host defense. Late cornified envelope (LCE) genes, located in the epidermal differentiation complex on chromosome 1, encode a family of 18 proteins of unknown function, whose expression is largely restricted to epidermis. Deletion of two members, LCE3B and LCE3C (LCE3B/C-del), is a widely-replicated psoriasis risk factor that interacts with the major psoriasis-psoriasis risk gene HLA-C*06...
November 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28596382/a-new-long-noncoding-rna-lncrna-is-induced-in-cutaneous-squamous-cell-carcinoma-and-down-regulates-several-anticancer-and-cell-differentiation-genes-in-mouse
#14
Gilles Ponzio, Roger Rezzonico, Isabelle Bourget, Richard Allan, Nicolas Nottet, Alexandra Popa, Virginie Magnone, Géraldine Rios, Bernard Mari, Pascal Barbry
Keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. Although some of the early events involved in this pathology have been identified, the subsequent steps leading to tumor development are poorly defined. We demonstrate here that the development of mouse tumors induced by the concomitant application of a carcinogen and a tumor promoter (7,12-dimethylbenz[a]anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA), respectively) is associated with the up-regulation of a previously uncharacterized long noncoding RNA (lncRNA), termed AK144841...
July 28, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28564614/enhanced-barrier-functions-and-anti-inflammatory-effect-of-cultured-coconut-extract-on-human-skin
#15
Soomin Kim, Ji Eun Jang, Jihee Kim, Young In Lee, Dong Won Lee, Seung Yong Song, Ju Hee Lee
Natural plant oils have been used as a translational alternative to modern medicine. Particularly, virgin coconut oil (VCO) has gained popularity because of its potential benefits in pharmaceutical, nutritional, and cosmetic applications. Cultured coconut extract (CCE) is an alternative end product of VCO, which undergoes a further bacterial fermentation process. This study aimed to investigate the effects of CCE on human skin. We analyzed the expression of skin barrier molecules and collagens after applying CCE on human explanted skin...
August 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28407621/potential-applications-of-phyto-derived-ceramides-in-improving-epidermal-barrier-function
#16
Efrem N Tessema, Tsige Gebre-Mariam, Reinhard H H Neubert, Johannes Wohlrab
The outer most layer of the skin, the stratum corneum, consists of corneocytes which are coated by a cornified envelope and embedded in a lipid matrix of ordered lamellar structure. It is responsible for the skin barrier function. Ceramides (CERs) are the backbone of the intercellular lipid membranes. Skin diseases such as atopic dermatitis and psoriasis and aged skin are characterized by dysfunctional skin barrier and dryness which are associated with reduced levels of CERs. Previously, the effectiveness of supplementation of synthetic and animal-based CERs in replenishing the depleted natural skin CERs and restoring the skin barrier function have been investigated...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28373353/clumping-factor-b-promotes-adherence-of-staphylococcus-aureus-to-corneocytes-in-atopic-dermatitis
#17
Orla M Fleury, Maeve A McAleer, Cécile Feuillie, Cécile Formosa-Dague, Emily Sansevere, Désirée E Bennett, Aisling M Towell, W H Irwin McLean, Sanja Kezic, D Ashley Robinson, Padraic G Fallon, Timothy J Foster, Yves F Dufrêne, Alan D Irvine, Joan A Geoghegan
Staphylococcus aureus skin infection is a frequent and recurrent problem in children with the common inflammatory skin disease atopic dermatitis (AD). S. aureus colonizes the skin of the majority of children with AD and exacerbates the disease. The first step during colonization and infection is bacterial adhesion to the cornified envelope of corneocytes in the outer layer, the stratum corneum. Corneocytes from AD skin are structurally different from corneocytes from normal healthy skin. The objective of this study was to identify bacterial proteins that promote the adherence of S...
June 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28369476/pnpla1-defects-in-patients-with-autosomal-recessive-congenital-ichthyosis-and-ko-mice-sustain-pnpla1-irreplaceable-function-in-epidermal-omega-o-acylceramide-synthesis-and-skin-permeability-barrier
#18
Mélanie Pichery, Anne Huchenq, Roger Sandhoff, Maella Severino-Freire, Sarra Zaafouri, Lukáš Opálka, Thierry Levade, Vanessa Soldan, Justine Bertrand-Michel, Emeline Lhuillier, Guy Serre, Annabel Maruani, Juliette Mazereeuw-Hautier, Nathalie Jonca
Autosomal recessive congenital ichthyosis (ARCI) is a heterogeneous group of monogenic genodermatoses that encompasses non-syndromic disorders of keratinization. The pathophysiology of ARCI has been linked to a disturbance in epidermal lipid metabolism that impaired the stratum corneum function, leading to permeability barrier defects. Functional characterization of some genes involved in ARCI contributed to the identification of molecular actors involved in epidermal lipid synthesis, transport or processing...
May 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28243135/repeated-short-climatic-change-affects-the-epidermal-differentiation-program-and-leads-to-matrix-remodeling-in-a-human-organotypic-skin-model
#19
Laetitia-Barbollat Boutrand, Amélie Thépot, Charlotte Muther, Aurélie Boher, Julie Robic, Christelle Guéré, Katell Vié, Odile Damour, Jérôme Lamartine
Human skin is subject to frequent changes in ambient temperature and humidity and needs to cope with these environmental modifications. To decipher the molecular response of human skin to repeated climatic change, a versatile model of skin equivalent subject to "hot-wet" (40°C, 80% relative humidity [RH]) or "cold-dry" (10°C, 40% RH) climatic stress repeated daily was used. To obtain an exhaustive view of the molecular mechanisms elicited by climatic change, large-scale gene expression DNA microarray analysis was performed and modulated function was determined by bioinformatic annotation...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28242341/lowering-relative-humidity-level-increases-epidermal-protein-deimination-and-drives-human-filaggrin-breakdown
#20
Laura Cau, Valérie Pendaries, Emeline Lhuillier, Paul R Thompson, Guy Serre, Hidenari Takahara, Marie-Claire Méchin, Michel Simon
BACKGROUND: Deimination (also known as citrullination), the conversion of arginine in a protein to citrulline, is catalyzed by a family of enzymes called peptidylarginine deiminases (PADs). Three PADs are expressed in the epidermis, one of their targets being filaggrin. Filaggrin plays a central role in atopic dermatitis and is a key protein for the epidermal barrier. It aggregates keratins and is cross-linked to cornified envelopes. Following its deimination, it is totally degraded to release free amino acids, contributing to the natural moisturizing factor (NMF)...
May 2017: Journal of Dermatological Science
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