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https://www.readbyqxmd.com/read/28092833/study-of-molecular-interactions-between-chitosan-and-vi-antigen
#1
Natália de Farias Silva, Raimundo Lopes da Silva, Kalene de Oliveira Almeida, Antônio Edilson Sousa do Nascimento-Júnior, Davi do Socorro Barros Brasil, José Otávio Carréra Silva-Júnior, Francisco Martins Teixeira, Roseane Maria Ribeiro-Costa
Chitosan has attracted much interest due to its special physical and chemical properties related to drug administration. Nanoparticles delivery systems from Vi Antigen are a promising approach in the struggle against typhoid fever. In this paper, we reported the obtainment and the characterization of Vi Antigen by Infrared spectroscopy as well as Molecular Modeling and Computational Chemistry studies of the Chitosan-Vi Antigen interaction through theoretical models. The results of the theoretical and experimental Infrared spectroscopy showed important bands related to N-Acetyl and O-Acetyl groups present in Vi Antigen...
December 31, 2016: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28090689/%C3%AE-aminoxy-peptoids-a-unique-peptoid-backbone-with-a-preference-for-cis-amide-bonds
#2
Viktoria Krieger, Emanuele Ciglia, Roland Thoma, Vera Vasylyeva, Benedikt Frieg, Nader de Sousa Amadeu, Thomas Kurz, Christoph Janiak, Holger Gohlke, Finn Kristian Hansen
α-Peptoids, or N-substituted glycine oligomers, are an important class of peptidomimetic foldamers with proteolytic stability. Nevertheless, the presence of cis-/trans-amide bond conformers, which contribute to the high flexibility of α-peptoids, is considered as a major drawback. A modified peptoid backbone with an improved control of the amide bond geometry could therefore help to overcome this limitation. Here we have performed the first thorough analysis of the folding propensities of α-aminoxy peptoids (or N-substituted 2-aminoxyacetic acid oligomers)...
January 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28089401/recycling-organic-wastes-to-agricultural-land-as-a-way-to-improve-its-quality-a-field-study-to-evaluate-benefits-and-risks
#3
P Alvarenga, P Palma, C Mourinha, M Farto, J Dôres, M Patanita, C Cunha-Queda, T Natal-da-Luz, M Renaud, J P Sousa
A field study was established to assess the effects of a sewage sludge (SS), a mixed municipal solid waste compost (MMSWC) and a compost produced from agricultural wastes (AWC), in a Vertisol, using Lolium multiflorum L. The amendments were applied for two consecutive years: 6, 12 and 24t dry matter ha(-1) for SS, and the amendment doses for MMSWC and AWC were calculated to deliver the same amount of organic matter (OM) per unit area. The amendments had significant beneficial effects on some soil properties (e...
January 12, 2017: Waste Management
https://www.readbyqxmd.com/read/28073829/dutpase-dut-is-mutated-in-a-novel-monogenic-syndrome-with-diabetes-and-bone-marrow-failure
#4
Reinaldo Sousa Dos Santos, Mathilde Daures, Anne Philippi, Sophie Romero, Lorella Marselli, Piero Marchetti, Valérie Senée, Delphine Bacq, Céline Besse, Baz Baz, Laura Marroquí, Sarah Ivanoff, Julien Masliah-Planchon, Marc Nicolino, Jean Soulier, Gérard Socié, Decio L Eizirik, Jean-François Gautier, Cécile Julier
We describe a new syndrome characterized by early onset diabetes mellitus, associated with bone marrow failure affecting mostly the erythrocytic lineage. Using whole exome sequencing in a remotely consanguineous patient from a family with two affected siblings, we identified a single homozygous missense mutation (chr15.hg19:g.48,626,619A>G) located in the dUTPase (DUT) gene (NCBI Gene ID: 1854), affecting both the mitochondrial (DUT-M p.Y142C) and the nuclear (DUT-N p.Y54C) isoforms. We found the same homozygous mutation in an unrelated consanguineous patient with diabetes and bone marrow aplasia from a family with two affected siblings, while none of the >60,000 subjects from the Exome Aggregation Consortium (ExAC) was homozygous for this mutation...
January 10, 2017: Diabetes
https://www.readbyqxmd.com/read/28073388/isolation-and-biological-and-molecular-characterization-of-neospora-caninum-nc-sp1-from-a-naturally-infected-adult-asymptomatic-cattle-bos-taurus-in-the-state-of-s%C3%A3-o-paulo-brazil
#5
Solange Oliveira, Rodrigo Martins Soares, Juliana Aizawa, Herbert Sousa Soares, Daniela Pontes Chiebao, Luis Miguel Ortega-Mora, Javier Regidor-Cerrillo, Natália Quadros Bressa Silva, Solange Maria Gennari, Hilda Fátima Jesus Pena
The biological and genetic diversity of Neospora caninum is very limited because of availability of only a few viable isolates worldwide. This study describes the isolation and biological and molecular characterization of a new viable isolate of N. caninum (NC-SP1), from a cattle in Brazil. Approximately 400 g of brain from a naturally infected adult male cattle from an abattoir was fed to a 2-month-old dog. Neospora-like oocysts were observed on day 7 post-inoculation (PI) and the duration of oocyst shedding was 14 days...
January 11, 2017: Parasitology
https://www.readbyqxmd.com/read/28072661/serum-oxytocin-concentration-in-patients-receiving-electroconvulsive-therapy-an-exploratory-study-and-review-of-literature
#6
Chinmay Barhale, M S V K Raju, Alka V Pawar, Krishna Kadam, Avinash De Sousa, Chittaranjan Andrade
BACKGROUND: Neuroendocrine biomarkers have long been studied in the context of electroconvulsive therapy (ECT). We prospectively assessed serum oxytocin change and moderators thereof in an exploratory study of patients receiving ECT. METHODS: Serum oxytocin concentrations were assessed immediately before and 1 to 3 minutes after the first ECT in 33 patients with schizophrenia (n = 14), other nonaffective psychosis (n = 6), mania (n = 10), and depression (n = 3) who received 6 to 7 bitemporal, brief-pulse ECTs...
January 9, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28065551/unsustainable-human-induced-injuries-to-the-critically-endangered-taiwanese-humpback-dolphins-sousa-chinensis-taiwanensis
#7
John Y Wang, Kimberly N Riehl, Shih Chu Yang, Claryana Araújo-Wang
The Critically Endangered Taiwanese humpback dolphin (Sousa chinensis taiwanensis) is endemic to inshore and estuarine waters of central western Taiwan. It numbers fewer than 75 individuals, is declining and faces a myriad of human threats. Data from a long-term photo-identification program on these dolphins allowed major injuries to be examined quantitatively. A large proportion (57.7%) of individuals had suffered major human-induced injuries that likely compromised their health, survivorship or reproductive potential and thus, the future of this subspecies...
January 5, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28064049/anti-diarrhoeal-therapeutic-potential-and-safety-assessment-of-sulphated-polysaccharide-fraction-from-gracilaria-intermedia-seaweed-in-mice
#8
Ana Carolina M Leódido, Luis E C Costa, Thiago S L Araújo, Douglas S Costa, Nayara A Sousa, Luan K M Souza, Francisca B M Sousa, Manoel D S Filho, Daniel F P Vasconcelos, Felipe R P Silva, Kerolayne M Nogueira, Alyne R Araújo, Francisco Clark N Barros, Ana Lúcia P Freitas, Jand Venes R Medeiros
Sulphated polysaccharides extracted from algae have been extensively studied for their diverse biological activities. Thus, the purpose of this study was to evaluate the chemical composition, the anti-diarrhoeal effect and acute toxicity of a sulphated polysaccharide fraction obtained from Gracilaria intermedia (SP-Gi). Initially, the FT-IR of SP-Gi revealed to be an agaran with sulphation at C-6 of the l-galactosyl residues. The anti-diarrhoeal activity of SP-Gi was evaluated in a castor oil-induced diarrhoea model...
January 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28063018/analysis-of-the-variation-in-low-level-laser-energy-density-on-the-crushed-sciatic-nerves-of-rats-a-morphological-quantitative-and-morphometric-study
#9
Eduardo Keiske Mastuda Ziago, Valéria Paula Sassoli Fazan, Mamie Mizusaki Iyomasa, Luiz Gustavo Sousa, Paula Yumi Yamauchi, Eunice Aparecida da Silva, Eduardo Borie, Ramón Fuentes, Fernando José Dias
The objective of this study was to evaluate three energy densities of low-level laser therapy (LLLT, GaAlAs, 780 nm, 40 mW, 0.04 cm(2)) for the treatment of lesions to peripheral nerves using the sciatic nerve of rats injured via crushing model (15 kgf, 5.2 MPa). Thirty Wistar rats (♂, 200-250 g) were divided into five groups (n = 6): C-control, not injured, and irradiated; L0-injured nerve without irradiation; L4-injured nerve irradiated with LLLT 4 J/cm(2) (0.16 J); L10-injured nerve irradiated with LLLT 10 J/cm(2) (0...
January 7, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28060415/gender-differences-in-affects-and-craving-in-alcohol-dependence-a-study-during-alcohol-detoxification
#10
Géraldine Petit, Olivier Luminet, Mariana Cordovil de Sousa Uva, Pauline Monhonval, Sophie Leclercq, Quentin Spilliaert, François Zammit, Pierre Maurage, Philippe de Timary
BACKGROUND: Alcohol craving is a major cause of relapse in alcohol-dependent (AD) patients. It is closely related to the high depression and anxiety symptoms that are frequently observed at the early stages of abstinence, and these comorbid symptoms might thus constitute a relapse factor when they persist after detoxification. As these negative affects are known to evolve during the detoxification process, the aim of this study was to investigate the course of the relation between affects and craving during detoxification, with a particular attention given to gender in light of the known differences in affects between AD men and women...
January 6, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28057569/a-novel-peroxidase-purified-from-marsdenia-megalantha-latex-inhibits-phytopathogenic-fungi-mediated-by-cell-membrane-permeabilization
#11
Henrique P Oliveira, Rodolpho G G Silva, Jose T A Oliveira, Daniele O B Sousa, Mirella L Pereira, Pedro F N Souza, Arlete A Soares, Valdirene M Gomes, Ana C O Monteiro-Moreira, Frederico B M B Moreno, Ilka M Vasconcelos
An antifungal class III peroxidase was purified from Marsdenia megalantha latex (named Mo-POX) using DEAE-cellulose and gel filtration chromatography on a Superose 12 HR 10/30 column. Mm-POX has an apparent molecular mass of 67.0kDa and a pI of 5.2, shares identity with other peroxidases, and follows Michaelis-Menten kinetics. It has a high affinity for guaiacol and hydrogen peroxide. The pH and temperature optima for Mm-POX were 5.0-7.0 and 60°C, respectively. The catalytic activity of Mm-POX was decreased in the presence of classic peroxidase inhibitors including azide, dithiothreitol, ethylenediamine tetraacetic acid, and sodium metabisulfite and high concentrations of Na(+), Mn(+), and salicylic acid...
January 3, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28045461/antidepressant-responsiveness-in-adulthood-is-permanently-impaired-after-neonatal-destruction-of-the-neurogenic-pool
#12
S Yu, I Zutshi, R Stoffel, J Zhang, A P Ventura-Silva, N Sousa, P S Costa, F Holsboer, A Patchev, O F X Almeida
The dynamic turnover of hippocampal neurons is implicated in the regulation of cognitive and affective behavior. Extending our previous demonstration that administration of dexamethasone (ND) to neonatal rats depletes the resident population of neural precursor cells (NPC) and restrains the size of the neurogenic regions, we now show that the adverse effects of ND persist into adulthood. Specifically, ND impairs repletion of the neurogenic pool and neurogenesis; ND also compromises cognitive performance, the ability to actively adapt to an acute stressor and, the efficacy of glucocorticoid (GC) negative feedback...
January 3, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28043340/using-real-time-pcr-to-identify-pregnancy-associated-glycoprotein-2-pag-2-in-water-buffalo-bubalus-bubalis-blood-in-early-pregnancy
#13
O Barbato, G Guelfi, V L Barile, L Menchetti, C Tortiello, C Canali, G Brecchia, G Traina, J F Beckers, N Melo de Sousa
This study investigates for the first time mRNA pregnancy-associated glycoprotein 2 (PAG-2) expression in blood cells during early pregnancy in water buffalo. The PAGs constitute a large family of glycoproteins expressed in the outer epithelial layer of the placenta in eutherian species. All PAGs are not concomitantly expressed throughout pregnancy; some of them are expressed in the earlier phases, whereas others appear later and are expressed over a shorter period. Twenty-one lactating buffaloes were analyzed-17 females were synchronized with PRID and artificially inseminated (AI), whereas four females were synchronized but not inseminated (control group)...
February 2017: Theriogenology
https://www.readbyqxmd.com/read/28043059/determining-factors-of-electrocardiographic-abnormalities-in-patients-with-epilepsy-a-case-control-study
#14
Jorge Murilo Barbosa de Sousa, Guilherme Loureiro Fialho, Peter Wolf, Roger Walz, Katia Lin
Sudden unexpected death in epilepsy (SUDEP) is a major cause of mortality in young patients with epilepsy (PWE). Although its mechanisms are still poorly understood, they may include cardiorespiratory dysfunction. Standard 12-lead electrocardiograms (ECGs) were obtained from 62 consecutive patients (aged 18-66y) with a definite diagnosis of epilepsy, without seizures at the day of ECG, and 57 healthy controls matched for sex, age and body mass index (BMI). All ECGs were evaluated by a blinded board-certified cardiologist...
December 20, 2016: Epilepsy Research
https://www.readbyqxmd.com/read/28029207/prospective-comparison-between-three-tavr-devices-acurate-neo-vs-corevalve-vs-sapien-xt-a-single-heart-team-experience-in-patients-with-severe-aortic-stenosis
#15
Tannas Jatene, Antonio Castro-Filho, Rafael A Meneguz-Moreno, Dimytri A Siqueira, Alexandre A C Abizaid, Auristela I O Ramos, Magaly Arrais, David C S Le Bihan, Rodrigo B M Barretto, Adriana C Moreira, Amanda G M R Sousa, J Eduardo Sousa
OBJECTIVE: We sought to compare the new transcatheter aortic valve replacement (TAVR) device ACURATE neo (ACT) with the already established CoreValve (MCV) and SAPIEN XT (SXT) for the treatment of severe aortic stenosis (AS). BACKGROUND: Very few data on TAVR devices are available beyond MCV and SAPIEN and there is no previous study comparing ACT with MCV and SXT. METHODS: We prospectively evaluated consecutive patients who underwent transfemoral TAVR for the treatment of severe AS...
December 28, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28028850/history-geography-and-host-use-shape-genome-wide-patterns-of-genetic-variation-in-the-redheaded-pine-sawfly-neodiprion-lecontei
#16
Robin K Bagley, Vitor C Sousa, Matthew L Niemiller, Catherine R Linnen
Divergent host use has long been suspected to drive population differentiation and speciation in plant-feeding insects. Evaluating the contribution of divergent host use to genetic differentiation can be difficult, however, as dispersal limitation and population structure may also influence patterns of genetic variation. In this study, we use double-digest restriction-associated DNA (ddRAD) sequencing to test the hypothesis that divergent host use contributes to genetic differentiation among populations of the redheaded pine sawfly (Neodiprion lecontei), a widespread pest that uses multiple Pinus hosts throughout its range in eastern North America...
December 28, 2016: Molecular Ecology
https://www.readbyqxmd.com/read/28027839/countercurrent-chromatography-separation-of-saponins-by-skeleton-type-from-ampelozizyphus-amazonicus-for-off-line-ultra-high-performance-liquid-chromatography-high-resolution-accurate-mass-spectrometry-analysis-and-characterisation
#17
Fabiana de Souza Figueiredo, Rita Celano, Danila de Sousa Silva, Fernanda das Neves Costa, Peter Hewitson, Svetlana Ignatova, Anna Lisa Piccinelli, Luca Rastrelli, Suzana Guimarães Leitão, Gilda Guimarães Leitão
Ampelozizyphus amazonicus Ducke (Rhamnaceae), a medicinal plant used to prevent malaria, is a climbing shrub, native to the Amazonian region, with jujubogenin glycoside saponins as main compounds. The crude extract of this plant is too complex for any kind of structural identification, and HPLC separation was not sufficient to resolve this issue. Therefore, the aim of this work was to obtain saponin enriched fractions from the bark ethanol extract by countercurrent chromatography (CCC) for further isolation and identification/characterisation of the major saponins by HPLC and MS...
December 19, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28024985/adverse-events-of-self-expandable-esophageal-metallic-stents-in-patients-with-long-term-survival-from-advanced-malignant-disease
#18
Vitor Sousa Medeiros, Bruno Costa Martins, Luciano Lenz, Maria Sylvia Ierardi Ribeiro, Gustavo Andrade de Paulo, Marcelo Simas Lima, Adriana Vaz Safatle-Ribeiro, Fabio Shighuehissa Kawaguti, Caterina Pennacchi, Sebastian N Geiger, Victor R Bastos, Ulysses Ribeiro-Junior, Rubens A Sallum, Fauze Maluf-Filho
BACKGROUND AND AIMS: Self-expandable metallic stents (SEMSs) are considered the best palliative treatment of dysphagia for patients with advanced esophageal cancer. Adverse events (AEs) are a major concern, especially in patients with better prognosis and longer survival. The present study aimed to evaluate the AEs of patients who survived longer than 6 months with esophageal stents in place. METHODS: This is a retrospective analysis of a prospectively collected database including all patients submitted to esophageal stent placement for the palliation of malignant diseases during the period from February 2009 to February 2014 at a tertiary-care academic center, who remained with the stent longer than 6 months...
December 23, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28012796/antigenic-fractions-from-taenia-crassiceps-metacestodes-obtained-by-hydrophobicity-for-the-immunodiagnosis-of-active-and-inactive-forms-of-neurocysticercosis-in-human-cerebrospinal-fluid-samples
#19
Gabriela B da Silva, Daniela S Nunes, José Eduardo N de Sousa, Maria do R F Gonçalves-Pires, Marcelo A Levenhagen, Julia M Costa-Cruz
This study aimed to evaluate the total extract of Taenia crassiceps metacestodes (TC) and its antigenic fractions obtained by Triton X-114 fractionation techniques, such as detergent (DC) and aqueous (AC), in the immunodiagnosis of human neurocysticercosis (NCC). Cerebrospinal fluid samples were divided into two groups: Group 1 (n=40), which was further divided into active (n=20) and inactive (n=20) NCC, and Group 2 (control group), which comprised 39 CSF samples from patients who had another neurological disorder, were suffering from other infectious diseases of the brain or had other parasitic infections...
December 21, 2016: Parasitology International
https://www.readbyqxmd.com/read/28010772/characterization-of-clostridium-thermocellum-b8-secretome-and-purified-cellulosomes-for-lignocellulosic-biomass-degradation
#20
Karen O Osiro, Brenda R de Camargo, Rachel Satomi, Pedro Ricardo V Hamann, Jéssica Pinheiro Silva, Marcelo Valle de Sousa, Betania F Quirino, Elaine N Aquino, Carlos R Felix, André Melro Murad, Eliane F Noronha
The main goal of the present study was a complete proteomic characterization of total proteins eluted from residual substrate-bound proteins (RSBP), and cellulosomes secreted by Clostridium thermocellum B8 during growth in the presence of microcrystalline cellulose as a carbon source. The second goal was to evaluate their potential use as enzymatic blends for hydrolyzing agro-industrial residues to produce fermentable sugars. Protein identification through LC-MS/MS mass spectrometry showed that the RSBP sample, in addition to cellulosomal proteins, contains a wide variety of proteins, including those without a well-characterized role in plant cell wall degradation...
February 2017: Enzyme and Microbial Technology
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