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https://www.readbyqxmd.com/read/28915875/plectranthus-amboinicus-essential-oil-and-carvacrol-bioactive-against-planktonic-and-biofilm-of-oxacillin-and-vancomycin-resistant-staphylococcus-aureus
#1
Sara Edwirgens Costa Benício Vasconcelos, Hider Machado Melo, Theodora Thays Arruda Cavalcante, Francisco Eduardo Aragão Catunda Júnior, Mário Geraldo de Carvalho, Francisca Gleire Rodrigues Menezes, Oscarina Viana de Sousa, Renata Albuquerque Costa
BACKGROUND: The emergence of multidrug-resistant bacteria is a worldwide concern and in order to find an alternative to this problem, the occurrence of antimicrobial compounds in Plectranthus amboinicus essential oil was investigated. Thus, this study aims to determine susceptibility of Staphylococcus aureus isolated from food to antibiotics, P. amboinicus essential oil (PAEO) and carvacrol. METHODS: Leaves and stem of P. amboinicus were used for extraction of essential oil (PAEO) by hydrodistillation technique and EO chemical analysis was performed by gas chromatography coupled to a mass spectrometer...
September 16, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28913909/local-delivery-of-strontium-ranelate-promotes-regeneration-of-critical-size-bone-defects-filled-with-collagen-sponge
#2
Bárbara Furtado Masalskas, Walter Martins Júnior, Graziela Bianchi Leoni, Ana Paula de Souza Faloni, Andrea Márcia Marcaccini, Yara Teresinha Corrêa Silva Sousa, Larissa Moreira Spinola de Castro-Raucci
The effect of local delivery of strontium ranelate (SR) on bone regeneration of critical size bone defects filled with collagen sponge was evaluated. Bone defects of 5 mm diameter created in rat calvaria were filled with collagen sponge (C); collagen sponge with 5 mM Sr(2+) SR (C5SR) or collagen sponge with 50 mM Sr(2+) SR (C50SR). After 2, 4 and 6 weeks, bone volume (BV), bone surface (BS), trabecular thickness (Tb.Th), trabecular number (Tb.N) and trabecular separation (Tb.Sp) were evaluated by computed microtomography...
September 15, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28912782/the-sand-fly-salivary-protein-lufaxin-inhibits-the-early-steps-of-the-alternative-pathway-of-complement-by-direct-binding-to-the-proconvertase-c3b-b
#3
Antonio F Mendes-Sousa, Vladimir Fazito do Vale, Naylene C S Silva, Anderson B Guimaraes-Costa, Marcos H Pereira, Mauricio R V Sant'Anna, Fabiano Oliveira, Shaden Kamhawi, José M C Ribeiro, John F Andersen, Jesus G Valenzuela, Ricardo N Araujo
Saliva of the blood feeding sand fly Lutzomyia longipalpis was previously shown to inhibit the alternative pathway (AP) of the complement system. Here, we have identified Lufaxin, a protein component in saliva, as the inhibitor of the AP. Lufaxin inhibited the deposition of C3b, Bb, Properdin, C5b, and C9b on agarose-coated plates in a dose-dependent manner. It also inhibited the activation of factor B in normal serum, but had no effect on the components of the membrane attack complex. Surface plasmon resonance (SPR) experiments demonstrated that Lufaxin stabilizes the C3b-B proconvertase complex when passed over a C3b surface in combination with factor B...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28903025/experimental-neospora-caninum-infection-in-chickens-gallus-gallus-domesticus-with-oocysts-and-tachyzoites-of-two-recent-isolates-reveals-resistance-to-infection
#4
Solange Oliveira, Juliana Aizawa, Herbert Sousa Soares, Daniela Pontes Chiebao, Márcio Botelho de Castro, Aline S Hora, Marcos Gomes Lopes, Gereon Schares, Mark C Jenkins, Oliver C H Kwok, Ricardo Augusto Dias, Solange Maria Gennari, Jitender P Dubey, Hilda Fátima Jesus Pena
The importance of birds in the biological cycle of Neospora caninum is not clear. We report unsuccessful Neospora infection in chickens (Gallus gallus domesticus) using two isolates of N. caninum. In experiment #1, 30 White Leghorn chickens were orally inoculated with viable N. caninum oocysts (NC-SP1 isolate, 200 oocysts per bird) via the crop at 21 days of age. Groups of three birds were euthanized at intervals of 7 days (a total of 9 weeks) and one group was challenged with the same oocyst dose at 37 days p...
September 10, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28902941/intestinal-inflammatory-and-redox-responses-to-the-perioperative-administration-of-teduglutide-in-rats
#5
Beatriz Pinto da Costa, Ana Cristina Gonçalves, Ana Margarida Abrantes, Paulo Matafome, Raquel Seiça, Ana Bela Sarmento-Ribeiro, Maria Filomena Botelho, Francisco Castro-Sousa
Purpose: To investigate the inflammatory and redox responses to teduglutide on an animal model of laparotomy and intestinal anastomosis. Methods: Wistar rats (n=62) were allocated into four groups: "Ileal Resection and Anastomosis" vs. "Laparotomy", each one split into "Postoperative Teduglutide Administration" vs. "No Treatment"; and euthanized at the third or the seventh day. Ileal and blood samples were recovered at the baseline and at the euthanasia. Flow cytometry was used to study the inflammatory response (IL-1α, MCP-1, TNF-α, IFN-γ and IL-4 levels), oxidative stress (cytosolic peroxides, mitochondrial reactive species, intracellular glutathione and mitochondrial membrane potential) and cellular viability and death (annexin V/propidium iodide double staining)...
August 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28902144/implementing-low-cost-community-based-exercise-programs-for-middle-aged-and-older-patients-with-type-2-diabetes-what-are-the-benefits-for-glycemic-control-and-cardiovascular-risk
#6
Romeu Mendes, Nelson Sousa, Victor Machado Reis, Jose Luis Themudo-Barata
BACKGROUND: The purpose of this study was to analyze the effects of a long-term, community-based, combined exercise program developed with low-cost exercise strategies on glycemic control and cardiovascular risk factors in middle-aged and older patients with type 2 diabetes. METHODS: Participants (n = 124; 63.25 ± 7.20 years old) engaged in either a 9-month supervised exercise program (n = 39; consisting of combined aerobic, resistance, agility/balance, and flexibility exercise; three sessions per week; 70 min per session) or a control group (n = 85) who maintained their usual care...
September 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28902118/concurrent-training-followed-by-detraining-does-the-resistance-training-intensity-matter
#7
António C Sousa, Daniel A Marinho, Maria H Gil, Mikel Izquierdo, David Rodríguez-Rosell, Henrique P Neiva, Mário C Marques
The aim of the present study was to analyze the training and detraining effects of concurrent aerobic training and resistance training against three different external loads on strength and aerobic variables. Thirty-two men were randomly assigned to four groups: low-load (LLG, n=9), moderate-load (MLG, n=9), high-load (HLG, n=8), and control group (CG, n=6). Resistance training consisted of FS with a low-load (40-55% 1RM), a moderate-load (55-70% 1RM) or a high-load (70-85% 1RM) combined with jump and sprint exercises...
September 6, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28898788/molecular-modelling-and-quantum-biochemistry-computations-of-a-naturally-occurring-bioremediation-enzyme-alkane-hydroxylase-from-pseudomonas-putida-p1
#8
B G de Sousa, J I N Oliveira, E L Albuquerque, U L Fulco, V E Amaro, C A G Blaha
Many species of bacteria involved in degradation of n-alkanes have an important constitutional metabolic enzyme, the alkane hydroxylase called AlkB, specialized in the conversion of hydrocarbons molecules that can be used as carbon and/or energy source. This enzyme plays an important role in the microbial degradation of oil, chlorinated hydrocarbons, fuel additives, and many other compounds. A number of these enzymes has been biochemically characterized in detail because the potential of alkane hydroxylases to catalyse high added-value reactions is widely recognized...
September 1, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28887850/wear-profile-of-canal-wall-surfaces-and-bond-strength-of-endodontic-sealers-after-in-situ-acid-challenge
#9
R Silva-Neto, M Sousa-Neto, J Pecora, R Palma-Dibb, A Souza-Gabriel
AIM: To evaluate the wear of root wall surfaces, the bond strength of sealers to dentine and the demineralization around filling material after the canals were exposed to acid challenge. METHODOLOGY: Eighty-seven roots of mandibular incisors were selected. Thirty-two were used in the bond strength in vitro study (n=8) and 55 in the in situ study (n=11). Root canals were prepared biomechanically and then filled with gutta-percha and AH Plus, MTA Fillapex, Sealapex or Endofill...
September 8, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28880930/liver-stiffness-measurement-predicts-liver-related-events-in-patients-with-chronic-hepatitis-c-a-retrospective-study
#10
Ana Zaida Gomez-Moreno, Daniel Pineda-Tenor, Maria Angeles Jimenez-Sousa, Juan Jose Sánchez-Ruano, Tomas Artaza-Varasa, Jose Saura-Montalban, Pablo Ryan, Salvador Resino
The management of patients with chronic hepatitis C (CHC) depends on their clinical stage. Thus, noninvasive early recognition of patients with CHC at high risk for developing liver-related events (LREs) is important because it ensures optimal preventative management strategies may be employed that can affect the course of CHC disease. Our aim was to determine whether liver stiffness measurement (LSM) in hepatitis C virus (HCV)-infected patients is associated with a risk of LREs, particularly in cirrhotic patients...
2017: PloS One
https://www.readbyqxmd.com/read/28871424/new-species-of-eimeria-apicomplexa-eimeriidae-from-thrichomys-fosteri-and-clyomys-laticeps-rodentia-echimyidae-of-the-brazilian-pantanal
#11
Wanessa Teixeira Gomes Barreto, Lúcio André Viana, Filipe Martins Santos, Grasiela Edith de Oliveira Porfírio, Alessandra Cabral Perdomo, Alanderson Rodrigues da Silva, Keyla Carstens Marques de Sousa, Michel Angelo Constantino de Oliveira, Heitor Miraglia Herrera, Gisele Braziliano de Andrade
The echimyid rodents Thrichomys fosteri and Clyomys laticeps are among the most commonly recorded small mammals in the Pantanal wetland of Brazil. These species play important ecological roles since they are the basis of the food chain of some predators and are parasitized by some pathogens. Knowledge of the eimerians that parasitize echimyid rodents in Brazil is absent, and only one report is available for South America. We therefore investigated parasitism by coccidians in the echimyids T. fosteri and C. laticeps in the Pantanal...
September 5, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28869827/effects-of-dexamethasone-and-nimesulide-on-bisphosphonate-related-osteonecrosis-of-the-jaw-an-experimental-study
#12
Camila Carvalho de Oliveira, Paulo Goberlânio de Barros Silva, Antonio Ernando Carlos Ferreira, Romélia Pinheiro Gonçalves, Fabrício Bitu de Sousa, Mário Rogério Lima Mota, Ana Paula Negreiros Nunes Alves
OBJECTIVE: To evaluate the effects of dexamethasone (DEX) and nimesulide (NIM) on Bisphosphonate-related Osteonecrosis of the Jaw (BRONJ) in rats. DESIGN: BRONJ was induced by zoledronic acid (ZA) infusion (0.2mg/kg) in Wistar rats (n=8), followed by extraction of the left lower first molar (BRONJ groups). Control groups (n=40) received saline (IV). For eight weeks, DEX (0.04, 0.4, 4mg/kg) or saline (SAL) were administered by gavage 24h before each infusion of ZA or saline (IV), or NIM (10...
August 30, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28864277/neolignans-from-leaves-of-nectandra-leucantha-lauraceae-display-in%C3%A2-vitro-antitrypanosomal-activity-via-plasma-membrane-and-mitochondrial-damages
#13
Simone S Grecco, Thais A Costa-Silva, Gerold Jerz, Fernanda S de Sousa, Vinicius S Londero, Mariana K Galuppo, Marta L Lima, Bruno J Neves, Carolina H Andrade, Andre G Tempone, João Henrique G Lago
Chagas disease is a neglected tropical disease, caused by the protozoan parasite Trypanosoma cruzi, which affects more than eight million people in Tropical and Subtropical countries especially in Latin America. Current treatment is limited to nifurtimox and benznidazole, both with reduced effectiveness and high toxicity. In this work, the n-hexane extract from leaves of Nectandra leucantha (Lauraceae) displayed in vitro antitrypanosomal activity against T. cruzi. Using several chromatographic steps, four related neolignans were isolated and chemically characterized as dehydrodieugenol B (1), 1-(8-propenyl)-3-[3'-methoxy-1'-(8-propenyl)-phenoxy]-4,5-dimethoxybenzene (2), 1-[(7S)-hydroxy-8-propenyl]-3-[3'-methoxy-1'-(8'-propenyl)-phenoxy]-4-hydroxy-5-methoxybenzene (3), and 1-[(7S)-hydroxy-8-propenyl]-3-[3'-methoxy-1'-(8'-propenyl)-phenoxy]-4,5-dimethoxybenzene (4)...
August 31, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28858875/clinical-metabolomics-and-glaucoma
#14
João Barbosa-Breda, Uwe Himmelreich, Bart Ghesquière, Amândio Rocha-Sousa, Ingeborg Stalmans
Glaucoma is one of the leading causes of irreversible blindness worldwide. However, there are no biomarkers that accurately help clinicians perform an early diagnosis or detect patients with a high risk of progression. Metabolomics is the study of all metabolites in an organism, and it has the potential to provide a biomarker. This review summarizes the findings of metabolomics in glaucoma patients and explains why this field is promising for new research. We identified published studies that focused on metabolomics and ophthalmology...
September 1, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28858523/combination-of-pdmaema-and-p%C3%AE-ae-results-in-a-strong-and-synergistic-transfection-activity
#15
Daniela Santo, Rosemeyre Amaral Cordeiro, Ana Sousa, Armenio Coimbra Serra, Jorge F J Coelho, Henrique Faneca
This work reports an innovative and very effective gene delivery nanosystem, based on the combination of PDMAEMA and PβAE homopolymers, that has the capacity to efficiently deliver genetic material into target cells, even in the presence of serum. The best formulation, prepared with the combination PDMAEMA:4PβAE at the 25/1 N/P ratio, presented a 700-fold and 220-fold higher transfection activity than that obtained with branched PEI-based polyplexes and block copolymer-based polyplexes, respectively. This new nanocarrier revealed high transgene expression in different human cells, including hard-to-transfect normal human astrocytes...
August 31, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28856326/coronary-stent-embolisation-to-an-iatrogenic-arteriovenous-fistula-an%C3%A2-unexpected-complication
#16
R Gouveia, P Monteiro, P Brandão, P Sousa, J Campos, A Coelho, R Augusto, N Coelho, A Canedo
INTRODUCTION: Systemic embolisation of stents represents a rare complication of coronary interventions. REPORT: The case of a patient with peripheral embolisation of a coronary stent while undergoing a coronary procedure for an ischaemic event is reported. The stent lodged at a previously created iatrogenic fistula joining the profunda femoral artery and the common femoral vein. An endovascular attempt was ineffective in treating this complication. The stent was removed surgically and the fistula repaired...
2017: EJVES Short Rep
https://www.readbyqxmd.com/read/28856323/serratia-liquefaciens-infection-of-a-previously-excluded-popliteal-artery-aneurysm
#17
A Coelho, M Lobo, V Martins, R Gouveia, P Sousa, J Campos, R Augusto, N Coelho, A Canedo
INTRODUCTION: Popliteal artery aneurysms (PAAs) are rare in the general population, but they account for nearly 70% of peripheral arterial aneurysms. There are several possible surgical approaches including exclusion of the aneurysm and bypass grafting, or endoaneurysmorrhaphy and interposition of a prosthetic conduit. The outcomes following the first approach are favorable, but persistent blood flow in the aneurysm sac has been documented in up to one third of patients in the early post-operative setting...
2017: EJVES Short Rep
https://www.readbyqxmd.com/read/28851571/comparative-analysis-of-different-transformed-saccharomyces-cerevisiae-strains-based-on-high-throughput-fourier-transform-infrared-spectroscopy
#18
Pedro N Sousa Sampaio, Cecília R Cruz Calado
This study shows the application of the Fourier transform mid-infrared spectroscopy (FT-MIR) associated with high-throughput technology to study the biochemical fingerprints of different Saccharomyces cerevisiae strains transformed with the same expression system along the similar cultivation in bioreactor. The phenotype, as well as the cellular metabolism and recombinant cyprosin biosynthesis, were determined. The differences observed were confirmed by conventional cyprosin activity protocol, and the metabolic evolution was analyzed using high-performance liquid chromatography technique...
August 26, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28844615/anti-jcv-antibody-serostatus-and-longitudinal-evaluation-in-a-portuguese-multiple-sclerosis-population
#19
I Correia, J Jesus-Ribeiro, S Batista, A I Martins, C Nunes, M C Macário, L Cunha, L Sousa
Multiple Sclerosis (MS) treatment with natalizumab is associated with Progressive Multifocal Leukoencephalopathy (PML). The risk of PML being related to the anti-JCV antibody index is well established, but there is less known about seroconversion rates in natalizumab-treated patients and longitudinal variation in the anti-JCV antibody index. Our objective was to assess anti-JCV antibody prevalence in an MS population and to evaluate the evolution of the anti-JCV antibody index in natalizumab-treated patients...
August 24, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28842567/insular-atrophy-at-the-prodromal-stage-of-dementia-with-lewy-bodies-a-vbm-dartel-study
#20
Daniel Roquet, Vincent Noblet, Pierre Anthony, Nathalie Philippi, Catherine Demuynck, Benjamin Cretin, Catherine Martin-Hunyadi, Paulo Loureiro de Sousa, Frédéric Blanc
Diffuse atrophy including the insula was previously demonstrated in dementia with Lewy bodies (DLB) patients but little is known about the prodromal stage of DLB (pro-DLB). In this prospective study, we used SPM8-DARTEL to measure gray matter (GM) and white matter (WM) atrophy in pro-DLB patients (n = 54), prodromal Alzheimer's disease (pro-AD) patients (n = 16), DLB patients at the stage of dementia (mild-DLB) (n = 15), and Alzheimer's disease patients at the stage of dementia (mild-AD) (n = 28), and compared them with healthy elderly controls (HC, n = 22)...
August 25, 2017: Scientific Reports
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