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https://www.readbyqxmd.com/read/29326898/effect-of-10-weight-loss-on-simulated-taekwondo-match-performance-a-randomized-trial
#1
Leonardo de Sousa Fortes, Gustavo César de Vasconcelos, Bruna Daniella de Vasconcelos Costa, Pedro Pinheiro Paes, Emerson Franchini
The objective of the present study was to analyze the effect of 10% body mass reduction on simulated taekwondo match performance. Thirty-one male taekwondo athletes were randomly distributed in two groups: weight loss group (n= 15) - athletes in this group reduced 5% body mass per week during two successive weeks, totaling 10% body mass reduction; control group (n= 16) - athletes in this group kept their body mass constant during the 2-week period. Twenty-four hours before and after this period, athletes performed a simulated 3-round taekwondo match (6 min)...
December 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29321183/ptgs2-polymorphism-rs689466-favors-breast-cancer-recurrence-in-obese-patients
#2
Daniely Regina Freitas-Alves, Hayra de Andrade Vieira-Monteiro, Diogo Nascimento Piranda, Marcelo Sobral-Leite, Taiana Sousa Lopes da Silva, Anke Bergmann, Samuel Dos Santos Valença, Jamila Alessandra Perini, Rosane Vianna-Jorge
Breast cancer is the leading cancer among women, and its increasing incidence is a challenge worldwide. Estrogen exposure is the main risk factor, but obesity among postmenopausal women has been shown to favor disease onset and progression. The link between obesity and mammary carcinogenesis involves elevated estrogen production and pro-inflammatory stimuli within the adipose tissue, with activation of the cyclooxygenase-2 pathway. Here, we evaluate the impact of the four most common cyclooxygenase-2 gene polymorphisms (rs689465, rs689466, rs20417 and rs20417), in combination with obesity, on the risk of breast cancer progression in a cohort of Brazilian breast cancer patients (N = 1038)...
January 10, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29320820/first-molecular-characterization-of-hypoderma-actaeon-in-cattle-and-red-deer-cervus-elaphus-in-portugal
#3
Haroon Ahmed, Sérgio Ramalho Sousa, Sami Simsek, Sofia Anastácio, Seyma Gunyakti Kilinc
Hypoderma spp. larvae cause subcutaneous myiasis in several animal species. The objective of the present investigation was to identify and characterize morphologically and molecularly the larvae of Hypoderma spp. collected from cattle (Bos taurus taurus) and red deer (Cervus elaphus) in the district of Castelo Branco, Portugal. For this purpose, a total of 8 larvae were collected from cattle (n=2) and red deer (n=6). After morphological identification of Hypoderma spp. larvae, molecular characterization was based on PCR-RFLP and mitochondrial CO1 gene sequence analysis...
December 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29317115/post-procedural-n-terminal-pro-brain-natriuretic-peptide-predicts-one-year-mortality-after-transcatheter-aortic-valve-implantation
#4
Nelson Carlos Vale, Rui Campante Teles, Sérgio Madeira, João Brito, Manuel Sousa Almeida, Tiago Nolasco, Joao Abecasis, Gustavo Rodrigues, João Carmo, Maria Furstenau, Regina Ribeiras, José Pedro Neves, Miguel Mendes
INTRODUCTION: Natriuretic peptides are ubiquitously used for diagnosis, follow-up and prognostic assessment in various heart conditions. N-terminal pro-brain natriuretic peptide (NT-proBNP) correlates with aortic stenosis severity, however its significance after transcatheter aortic valve implantation (TAVI) is not well established. AIM: We aimed to assess the prognostic value of NT-proBNP at one year in patients undergoing TAVI. METHODS: This single-center retrospective analysis included 151 patients in whom both baseline and one-month post-procedure NT-proBNP were measured, from 206 consecutive patients undergoing TAVI between November 2008 and December 2014...
January 6, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29315462/aprepitant-as-a-fourth-antiemetic-prophylactic-strategy-in-high-risk-patients-a-double-blind-randomized-trial
#5
L C de Morais, A M Sousa, G F Flora, T R Grigio, G M N Guimarães, H A Ashmawi
BACKGROUND: Post-operative nausea and vomiting (PONV) is one of the most important causes of patient discomfort after laparoscopic surgeries despite the use of a multimodal pharmacological approach. This study assessed whether the addition of aprepitant to a multimodal regimen would further decrease the incidence of PONV in high-risk patients. METHODS: Apfel-score three or four patients, scheduled for laparoscopic procedures to treat abdominal or pelvic cancer, were randomized to receive oral starch (control group) or 80 mg of oral aprepitant (treatment group) before induction of anaesthesia in a double-blind study...
January 7, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29311619/in-situ-immune-response-and-mechanisms-of-cell-damage-in-central-nervous-system-of-fatal-cases-microcephaly-by-zika-virus
#6
Raimunda S S Azevedo, Jorge R de Sousa, Marialva T F Araujo, Arnaldo J Martins Filho, Bianca N de Alcantara, Fernanda M C Araujo, Maria G L Queiroz, Ana C R Cruz, Beatriz H Baldez Vasconcelos, Jannifer O Chiang, Lívia C Martins, Livia M N Casseb, Eliana V da Silva, Valéria L Carvalho, Barbara C Baldez Vasconcelos, Sueli G Rodrigues, Consuelo S Oliveira, Juarez A S Quaresma, Pedro F C Vasconcelos
Zika virus (ZIKV) has recently caused a pandemic disease, and many cases of ZIKV infection in pregnant women resulted in abortion, stillbirth, deaths and congenital defects including microcephaly, which now has been proposed as ZIKV congenital syndrome. This study aimed to investigate the in situ immune response profile and mechanisms of neuronal cell damage in fatal Zika microcephaly cases. Brain tissue samples were collected from 15 cases, including 10 microcephalic ZIKV-positive neonates with fatal outcome and five neonatal control flavivirus-negative neonates that died due to other causes, but with preserved central nervous system (CNS) architecture...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29306351/dissection-of-ancestral-genetic-contributions-to-creole-goat-populations
#7
N Sevane, O Cortés, L T Gama, A Martínez, P Zaragoza, M Amills, D O Bedotti, C Bruno de Sousa, J Cañon, S Dunner, C Ginja, M R Lanari, V Landi, P Sponenberg, J V Delgado
Goats have played a key role as source of nourishment for humans in their expansion all over the world in long land and sea trips. This has guaranteed a place for this species in the important and rapid episode of livestock expansion triggered by Columbus' arrival in the Americas in the late 1400s. The aims of this study are to provide a comprehensive perspective on genetic diversity in American goat populations and to assess their origins and evolutionary trajectories. This was achieved by combining data from autosomal neutral genetic markers obtained in more than two thousand samples that encompass a wide range of Iberian, African and Creole goat breeds...
January 8, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29305138/musk-myasthenia-gravis-and-pregnancy
#8
Ernestina Santos, Antonio Braga, Denis Gabriel, Sara Duarte, Ana Martins da Silva, Ilda Matos, Marta Freijo, Joao Martins, Fernando Silveira, Goreti Nadais, Filipa Sousa, Carla Fraga, Rosa Santos Silva, Carlos Lopes, Guilherme Gonçalves, Clara Pinto, Jorge Sousa Braga, Maria Isabel Leite
Muscle specific kinase (MuSK) myasthenia gravis (MG, MuSK-MG) is a rare subgroup of MG affecting mainly women during childbearing years. We investigated the influence of pregnancy in the course of MuSK-MG and pregnancy outcomes in females with MuSK-MG. A multicentre cohort of 17 women with MuSK-MG was studied retrospectively; 13 of them with ≥1 pregnancy. MuSK-MG onset age was 35,4 years; 23,0% had other autoimmune disorder; 46,2% were treatment refractory. Thirteen women experienced 27 pregnancies, either after MG onset (group I) (n = 4; maternal age at conception = 29...
November 28, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29304796/referral-gynecological-ambulatory-clinic-principal-diagnosis-and-distribution-in-health-services
#9
Adna Thaysa Marcial da Silva, Camila Lohmann Menezes, Edige Felipe de Sousa Santos, Paulo Francisco Ramos Margarido, José Maria Soares, Edmund Chada Baracat, Luiz Carlos de Abreu, Isabel Cristina Esposito Sorpreso
BACKGROUND: The association between gynecological diagnoses and their distribution in the health sectors provides benefits in the field of women's health promotion and in medical and interdisciplinary education, along with rationalization according to level of care complexity. Thus, the objective is analyze the clinical-demographic characteristics, main diagnoses in gynecological ambulatory care, and their distribution in health services. METHOD: This is a research project of retrospective audit study design with a chart review of data from 428 women treated at University Ambulatory Clinic of Women's Health, the facility in gynecology and training for Family and Community Medical Residents, São Paulo, Brazil, from 2012 to 2014...
January 5, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29297560/influence-of-root-canal-filling-techniques-on-sealer-penetration-and-bond-strength-to-dentin
#10
Luciana Martins Domingues de Macedo, Yara Silva-Sousa, Silvio Rocha Corrêa da Silva, Samantha Schaffer Pugsley Baratto, Flares Baratto-Filho, Fuad Jacob Abi Rached-Júnior
The influence of root canal filling techniques on the penetration of AH Plus into dentinal tubules was evaluated using confocal laser scanning microscopy (CLSM) and the impact on the bond strength of the filling material on the root dentin was evaluated using the push-out test. Roots of the maxillary central incisors (n=40) were prepared with ProTaper Universal and assigned to four groups: lateral condensation, vertical compaction, modified Tagger hybrid and single cone. After root canal filling with gutta-percha and AH Plus, along with the addition of 0...
May 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29278557/discrepancies-between-alzheimer-s-disease-patients-and-caregivers-ratings-about-patients-quality-of-life-a-1-year-observation-study-in-brazil
#11
Maria F B Sousa, Raquel L Santos, Pedro Simões, Josep L Conde-Sala, Marcia C N Dourado
OBJECTIVES: We investigated the factors associated with discrepancies between patients' and caregivers' ratings about patients' general quality of life (QoL) and about the domains of Quality of Life in Alzheimer's disease (QoL-AD) Scale at baseline and 12 months. METHODS: This was a longitudinal study that comprised 114 outpatients with AD and their caregivers. Patients were assessed with the QoL-AD, Mini-mental State Examination, Assessment Scale of Psychosocial Impact of the Diagnosis of Dementia, Cornell Scale for Depression, Functional Activities Questionnaire, and Neuropsychiatric Inventory, and Clinical Dementia Rating Scale...
December 22, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29274162/low-level-laser-therapy-and-anesthetic-infiltration-for-orofacial-pain-in-patients-with-fibromyalgia-a-randomized-clinical-trial
#12
R-C-V de Souza, E de Sousa, K-O Scudine, U Meira, E de Oliveira E Silva, A Gomes, F-A Limeira-Junior
BACKGROUND: To compare the analgesic effect of anesthetic infiltration of lidocaine 2% and low-level laser therapy (LLLT) by GaAlAs into tender points of patients with orofacial pain and fibromyalgia (FM). MATERIAL AND METHODS: A randomized clinical trial was performed with adults (N=66) that were allocated into two groups (1:1): Group A received LLLT irradiation by Diode Laser GaAlAs (780nm) with expositions twice a week during six weeks and Group B was treated with anesthetic infiltration of lidocaine 2% without vasoconstrictor once a week for four weeks...
December 23, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29273492/micro-computed-tomographic-evaluation-of-the-shaping-ability-of-xp-endo-shaper-irace-and-edgefile-systems-in-long-oval-shaped-canals
#13
Marco A Versiani, Kleber K T Carvalho, Jardel F Mazzi-Chaves, Manoel D Sousa-Neto
INTRODUCTION: This study evaluated the shaping ability of the XP-endo Shaper (FKG Dentaire SA, La Chaux-de-Fonds, Switzerland), iRaCe (FKG Dentaire SA), and EdgeFile (EdgeEndo, Albuquerque, NM) systems using micro-computed tomographic (micro-CT) technology. METHODS: Thirty long oval-shaped canals from mandibular incisors were matched anatomically using micro-CT scanning (SkyScan1174v2; Bruker-microCT, Kontich, Belgium) and distributed into 3 groups (n = 10) according to the canal preparation protocol (ie, XP-endo Shaper, iRaCe, and EdgeFile systems)...
December 19, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29259388/genital-tract-infections-in-an-isolated-community-100-women-of-the-pr%C3%A3-ncipe-island
#14
Pedro Vieira-Baptista, Svitrigaile Grinceviciene, Gert Bellen, Carlos Sousa, Conceição Saldanha, Davy Vanden Broeck, John-Paul Bogers, Gilbert Donders
Objective: To characterize the vaginal microbiome and the rate of sexually transmitted infections (STIs) in the women of Príncipe (São Tomé and Príncipe). Methods: Cross-sectional study of 100 consecutive women, invited for a free appointment and cervical cancer screening. A vaginal slide (wet mount microscopy) and a cervical sample (ThinPrep®) (Pap test, high risk human papillomavirus [HR-HPV], N. gonorrhea [NG], T. vaginalis [TV], and C. trachomatis [CT]) were obtained...
2017: Infectious Diseases in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29246654/proinflammatory-cytokines-in-early-childhood-caries-salivary-analysis-in-the-mother-children-pair
#15
Cecilia Claudia Costa Ribeiro, Crysthian de Jesus Borges Pachêco, Elizabeth Lima Costa, Lorena Lúcia Costa Ladeira, José Ferreira Costa, Rubenice Amaral da Silva, Cadidja Dayanne Sousa Carmo
HYPOTHESIS: Proinflammatory cytokines are increased in saliva of mother/children pairs with caries. DESIGN: Case-control study involving caries-free children (n = 20) and children with early childhood caries (ECC) (n = 20), and their mothers (n = 40). The maternal variables analyzed were waist circumference (WC), decayed, missing and filled teeth (DMFT) and sugar intake; and in the children were body mass index (BMI), def-t and sugar intake. Salivary levels of VEGF, IL-6 and TNF-α were analyzed of mother/children pairs...
December 12, 2017: Cytokine
https://www.readbyqxmd.com/read/29241141/plasma-exchange-in-severe-acute-relapses-of-multiple-sclerosis-results-from-a-portuguese-cohort
#16
Inês Correia, Joana Jesus Ribeiro, Luís Isidoro, Sónia Batista, Carla Nunes, Carmo Macário, Catarina Borges, Jorge Tomaz, Lívia Sousa
BACKGROUND: Relapses in Multiple Sclerosis (MS) are often associated with significant disability impairment which is resultant from poor response to corticosteroids. In such severe cases, plasma exchange (PLEX) may be used, although only a few studies with MS patients have been reported. Our objective was to evaluate the effectiveness of PLEX in severe relapses of MS. METHODS: Retrospective study of MS patients treated with PLEX in acute relapses. Data regarding EDSS, annualized relapse rate (ARR), treatment with corticosteroids, number of PLEX sessions, adverse events, and gadolinium enhancement in brain MRI were analysed...
December 7, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29239008/dermocystidium-sp-infection-in-farmed-hybrid-fish-colossoma-macropomum%C3%A2-%C3%A3-%C3%A2-piaractus-brachypomus-in-brazil
#17
R Y Fujimoto, M V S Couto, N C Sousa, D G Diniz, J A P Diniz, R R Madi, M L Martins, J C Eiras
No abstract text is available yet for this article.
December 13, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/29237021/human-specific-subcellular-compartmentalization-of-p-element-induced-wimpy-testis-like-piwil-granules-during-germ-cell-development-and-spermatogenesis
#18
Maria Gomes Fernandes, Nannan He, Fang Wang, Liesbeth Van Iperen, Cristina Eguizabal, Roberto Matorras, Bernard A J Roelen, Susana M Chuva De Sousa Lopes
STUDY QUESTION: What is the dynamics of expression of P-element induced wimpy testis-like (PIWIL) proteins in the germline during human fetal development and spermatogenesis? SUMMARY ANSWER: PIWIL1, PIWIL2, PIWIL3 and PIWIL4 were expressed in a sex-specific fashion in human germ cells (GC) during development and adulthood. PIWILs showed a mutually exclusive pattern of subcellular localization. PIWILs were present in the intermitochondrial cement and a single large granule in meiotic GC and their expression was different from that observed in mice, highlighting species-differences...
December 11, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29234086/n-acetylcysteine-functionalized-coating-avoids-bacterial-adhesion-and-biofilm-formation
#19
Fabíola Costa, Daniela M Sousa, Paula Parreira, Meriem Lamghari, Paula Gomes, M Cristina L Martins
N-acetyl cysteine (NAC) is an FDA-approved drug clinically applied on a broad range of pathologies. Further research has been conducted with this drug to benefit from its antimicrobial activity potential. However, NAC has a very short half-life and therefore strategies that accomplish high local concentrations would be beneficial. In this study, covalent immobilization of NAC was performed, in order to obtain long-lasting high local concentration of the drug onto a chitosan(Ch)-derived implant-related coating...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29230390/her2-overexpression-in-retinoblastoma-a-potential-therapeutic-target
#20
David Cordeiro Sousa, Pablo Zoroquiain, Maria Eugenia Orellana, Ana Beatriz Dias, Evangelina Esposito, Miguel N Burnier
Background: Retinoblastoma (RB) is the most common primary intraocular malignancy. Current therapies are associated with high morbidity in the short- and long-term. Human epidermal growth factor receptor 2 (HER2) is a transmembrane protein detected in 15-30% of breast cancers, but it has also been described in other malignancies. Recently, it has been claimed that a truncated version of this protein is expressed in RB, responsive to directed therapies in vitro. We scored HER2 overexpression in RB tissue samples and discussed its potential clinical utility...
September 2017: Ocular Oncology and Pathology
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