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https://www.readbyqxmd.com/read/28816488/direct-and-indirect-effects-of-child-abuse-and-environmental-stress-a-lifecourse-perspective-on-adversity-and-depressive-symptoms
#1
Cindy Sousa, W Alex Mason, Todd I Herrenkohl, Dana Prince, Roy C Herrenkohl, M Jean Russo
There is a great deal of evidence about the mental health implications of physical child abuse and environmental stressors, or hardships that people experience at the household and neighborhood level (e.g., neighborhood violence; economic hardship, substance abuse, or conflict among family members). Yet, studies often focus on either abuse or environmental stress, not both, or examine abuse and environmental stressors as a combined set of experiences. Less is known, therefore, about how child abuse and environmental stress might work as either distinct or interrelated risks to diminish mental health over time...
August 17, 2017: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/28814867/exploring-cellular-uptake-of-iron-oxide-nanoparticles-associated-with-rhodium-citrate-in-breast-cancer-cells
#2
Natalia L Chaves, Irina Estrela-Lopis, Julia Böttner, Cláudio Ap Lopes, Bruna C Guido, Aparecido R de Sousa, Sônia N Báo
Nanocarriers have the potential to improve the therapeutic index of currently available drugs by improving their efficacy and achieving therapeutic steady-state levels over an extended period. The association of maghemite-rhodium citrate (MRC) nanoparticles (NPs) has the potential to increase specificity of the cytotoxic action. However, the interaction of these NPs with cells, their uptake mechanism, and subcellular localization need to be elucidated. This work evaluates the uptake mechanism of MRC NPs in metastatic and nonmetastatic breast cancer-cell models, comparing them to a nontumor cell line...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28807218/teduglutide-effects-on-gene-regulation-of-fibrogenesis-on-an-animal-model-of-intestinal-anastomosis
#3
Beatriz P Costa, Ana C Gonçalves, Ana M Abrantes, Paulo Matafome, Raquel Seiça, Ana B Sarmento-Ribeiro, Maria Filomena Botelho, Francisco Castro-Sousa
BACKGROUND: Teduglutide is an enterotrophic analog of glucagon-like peptide 2 approved for the rehabilitation of short-bowel syndrome. This study aims to analyze the effects of teduglutide administration on the gene regulation of fibrogenesis during the intestinal anastomotic healing on an animal model. METHODS: Wistar rats (n = 62) were assigned into four groups: "Ileal Resection and Anastomosis" or "Laparotomy," each one subdivided into "Postoperative Teduglutide Administration" or "No Treatment," and sacrificed at the third or at the seventh days, with ileal sample harvesting...
August 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28806579/access-to-emergency-care-services-a-transversal-ecological-study-about-brazilian-emergency-health-care-network
#4
T A H Rocha, N C da Silva, P V Amaral, A C Q Barbosa, J V M Rocha, V Alvares, D G de Almeida, E Thumé, E B A F Thomaz, R C de Sousa Queiroz, M R de Souza, A Lein, N Toomey, C A Staton, J R N Vissoci, L A Facchini
OBJECTIVES: Studies of health geography are important in the planning and allocation of emergency health services. The geographical distribution of health facilities is an important factor in timely and quality access to emergency services; therefore, the present study analyzed the emergency health care network in Brazil, focusing the analysis at the roles of small hospitals (SHs). STUDY DESIGN: Cross-sectional ecological study. METHODS: Data were collected from 9429 hospitals of which 3524 were SHs and 5905 were high-complexity centers (HCCs)...
August 11, 2017: Public Health
https://www.readbyqxmd.com/read/28803976/canavalia-bonariensis-lectin-molecular-bases-of-glycoconjugates-interaction-and-antiglioma-potential
#5
Benildo Sousa Cavada, Mayara Torquato Lima Silva, Vinicius Jose Silva Osterne, Vanir Reis Pinto-Junior, Ana Paula Machado do Nascimento, Ingrid Alessandra Victoria Wolin, Isabella Aparecida Heinrich, Clareane Avelino Simplicio Nobre, Cleane Gomes Moreira, Claudia Figueiredo Lossio, Cintia Renata Costa Rocha, Jorge Luiz Martins, Kyria Santiago Nascimento, Rodrigo Bainy Leal
CaBo is a mannose/glucose-specific lectin purified from seeds of Canavalia bonariensis. In the present work, we report the CaBo crystal structure determined to atomic resolution in the presence of X-man, a specific ligand. Similar to the structural characteristics of other legume lectins, CaBo presented the jellyroll motif, a metal binding site occupied by calcium and manganese ions close to the carbohydrate-recognition domain (CRD). In vitro test of CaBo cytotoxicity against glioma cells demonstrated its ability to decrease the cellular viability and migration by induction of autophagy and cell death...
August 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28801055/therapy-with-mesenchymal-stromal-cells-or-conditioned-medium-reverse-cardiac-alterations-in-a-high-fat-diet-induced-obesity-model
#6
P S Daltro, B C Barreto, P G Silva, P Chenaud Neto, P H F Sousa Filho, D Santana Neta, G B Carvalho, D N Silva, B D Paredes, A C de Alcantara, L A R Freitas, R D Couto, R R Santos, B S F Souza, M B P Soares, S G Macambira
BACKGROUND: Obesity is associated with numerous cardiac complications, including arrhythmias, cardiac fibrosis, remodeling and heart failure. Here we evaluated the therapeutic potential of mesenchymal stromal cells (MSCs) and their conditioned medium (CM) to treat cardiac complications in a mouse model of high-fat diet (HFD)-induced obesity. METHODS: After obesity induction and HFD withdrawal, obese mice were treated with MSCs, CM or vehicle. Cardiac function was assessed using electrocardiography, echocardiography and treadmill test...
August 8, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28776822/ripple-mapping-initial-multicenter-experience-of-an-intuitive-approach-to-overcoming-the-limitations-of-3d-activation-mapping
#7
Vishal Luther, Nuno Cortez-Dias, Luis Carpinteiro, João de Sousa, Richard Navaratnum Balasubramaniam, Sharad C Agarwal, David Farwell, Solomon Mark Sopher, Girish Babu, Richard Till, Nikki Jones, Stuart Tan, Anthony Chow, Martin Lowe, Jem Lane, Naveen Pappachan, Nick Wf Linton, Prapa Kanagaratnam
BACKGROUND: Ripple Mapping (RM) displays electrograms as moving bars over a 3D surface displaying bipolar voltage, and has shown in a single-center series to be effective for atrial tachycardia (AT) mapping without annotation of local activation time or window-of-interest assignment. We tested the reproducibility of these findings in operators naive to RM, using it for the first time in post ablation AT. METHODS: Maps were collected with multielectrode catheters and CARTO ConfiDENSE...
August 4, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28776187/alzheimer-s-disease-related-amyloid-%C3%AE-1-42-peptide-induces-the-loss-of-human-sperm-function
#8
R S Tavares, S Martins, T Almeida-Santos, A P Sousa, J Ramalho-Santos, O A da Cruz E Silva
Characteristically identified as the main component of senile plaques present in patients suffering from Alzheimer's disease, Aβ has been detected in human testis and reproductive fluids, but its effect on spermatozoa has not been addressed. The present study evaluated whether the most toxic and aggregant amyloid precursor protein (APP)-proteolytic product, amyloid-β1-42 (Aβ1-42), was capable of affecting sperm functionality. Normozoospermic samples were either exposed to different Aβ1-42 doses or to the untreated and scrambled controls for a maximum of 48 h at 37 °C and 5%CO2, and motility, viability and mitochondrial status were evaluated...
August 3, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28771213/essential-oils-and-their-constituents-an-alternative-source-for-novel-antidepressants
#9
REVIEW
Damião P de Sousa, Rayanne H N Silva, Epifanio F da Silva, Elaine C Gavioli
Depression is a disease that has affected a high proportion of the world's population and people of different ages, incapacitating them from good performance at work and in social relationships, and causing emotional disorders to millions of families. Therefore, the search for new therapeutic agents is considered a priority for the discovery of more effective forms of treatment. In this review, studies of essential oils and their constituents in experimental models related to depression are discussed. The mechanisms of action of the oils and the presence of psychoactive constituents in their chemical compositions are discussed...
August 3, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28756296/pathway-discovery-using-transcriptomic-profiles-in-adult-onset-severe-asthma
#10
Pieter-Paul Hekking, Matt J Loza, Stelios Pavlidis, Bertrand De Meulder, Diane Lefaudeux, Fred Baribaud, Charles Auffray, Ariane H Wagener, Paul Brinkman, Rene Lutter, ArunaT Bansal, Ana R Sousa, Steve Bates, Yannis Pandis, Louise J Fleming, Dominique E Shaw, Stephen J Fowler, Y Guo, Andrea Meiser, Kai Sun, Julie Corfield, Peter Howarth, Elisabeth H Bel, Ian M Adcock, K F Chung, Ratko Djukanovic, Peter J Sterk
RATIONALE: Adult-onset severe asthma is characterized by highly symptomatic disease despite high intensity asthma treatments. Understanding of the underlying pathways of this heterogeneous disease needed for the development of targeted treatments. Gene Set Variation Analysis (GSVA) is a statistical technique to identify gene profiles in heterogeneous samples. OBJECTIVE: To identify gene profiles associated with adult-onset severe asthma. METHODS: This was a cross-sectional, observational study in which adult patients with adult-onset of asthma (defined as starting at ≥18yrs old) as compared to childhood-onset severe asthma (<18 yrs) were selected from the U-BIOPRED cohort...
July 26, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28755514/severe-maternal-morbidity-and-perinatal-outcomes-of-multiple-pregnancy-in-the-brazilian-network-for-the-surveillance-of-severe-maternal-morbidity
#11
Danielly S Santana, José G Cecatti, Samira M Haddad, Mary A Parpinelli, Maria L Costa, Fernanda G Surita, Maria H Sousa
OBJECTIVE: To compare severe maternal complications (potentially life-threatening conditions [PLTCs], maternal near miss [MNM], and maternal death) and perinatal outcomes between multiple and singleton pregnancies. METHODS: A secondary analysis was undertaken using data from the Brazilian Network for Surveillance of Severe Maternal Morbidity (prospective surveillance of morbidities in 27 Brazilian obstetric units between July 2009 and June 2010). Health indicators and criteria used for PLTCs and MNM were assessed...
July 29, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28754321/crystal-structure-of-pisum-arvense-seed-lectin-pal-and-characterization-of-its-interaction-with-carbohydrates-by-molecular%C3%A2-docking-and-dynamics
#12
Vanir Reis Pinto-Junior, Mayara Queiroz Santiago, Camila Bezerra Nobre, Vinicius Jose Silva Osterne, Rodrigo Bainy Leal, Joao Batista Cajazeiras, Claudia Figueiredo Lossio, Bruno Anderson Matias Rocha, Maria Gleiciane Queiroz Martins, Clareane Avelino Simplicio Nobre, Mayara Torquato Lima Silva, Kyria Santiago Nascimento, Benildo Sousa Cavada
The Pisum arvense lectin (PAL), a legume protein belonging to the Vicieae tribe, is capable of specific recognition of mannose, glucose and its derivatives without altering its structure. In this work, the three-dimensional structure of PAL was determined by X-ray crystallography and studied in detail by a combination of molecular docking and molecular dynamics (MD). Crystals belonging to monoclinic space group P21 were grown by the vapor diffusion method at 293 K. The structure was solved at 2.16 Å and was similar to that of other Vicieae lectins...
July 25, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28751073/efficacy-of-new-natural-biomodification-agents-from-anacardiaceae-extracts-on-dentin-collagen-cross-linking
#13
M A Moreira, N O Souza, R S Sousa, D Q Freitas, M V Lemos, D M De Paula, F J N Maia, D Lomonaco, S E Mazzetto, V P Feitosa
OBJECTIVES: Several polyphenols from renewable sources were surveyed for dentin biomodification. However, phenols from cashew nut shell liquid (CNSL, Anacardium occidentale) and from Aroeira (Myracrodruon urundeuva) extract have never been evaluated. The present investigation aimed to compare the dentin collagen crosslinking (biomodification) effectiveness of polyphenols from Aroeira stem bark extract, proanthocyanidins (PACs) from grape-seed extract (Vitis vinifera), cardol and cardanol from CNSL after clinically relevant treatment for one minute...
July 24, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28747911/f1-domain-of-the-leishmania-leishmania-donovani-nucleoside-hydrolase-promotes-a-th1-response-in-leishmania-leishmania-infantum-cured-patients-and-in-asymptomatic-individuals-living-in-an-endemic-area-of-leishmaniasis
#14
Eugenia Carrillo, Laura Fernandez, Ana Victoria Ibarra-Meneses, Micheli L B Santos, Dirlei Nico, Paula M de Luca, Cristiane Bani Correa, Roque Pacheco de Almeida, Javier Moreno, Clarisa B Palatnik-de-Sousa
The Leishmania (Leishmania) donovani nucleoside hydrolase NH36 is the main antigen of the Leishmune(®) vaccine and one of the promising candidates for vaccination against visceral leishmaniasis. The antigenicity of the N-terminal (F1), the central (F2), or the C-terminal recombinant domain (F3) of NH36 was evaluated using peripheral blood mononuclear cells (PBMC) from individuals infected with L. (L.) infantum from an endemic area of visceral leishmaniasis of Spain. Both NH36 and F1 domains significantly increased the PBMC proliferation stimulation index of cured patients and infected asymptomatic individuals compared to healthy controls...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28746446/t-lymphocytes-and-macrophages-in-the-intestinal-tissues-of-dogs-infected-with-leishmania-infantum
#15
Diogo Tiago da Silva, Maria Luana Alves, Júlio Cesar Pereira Spada, Aline Cristine da Silva, Rita de Cássia Viveiros da Silveira, Trícia Maria Ferreira de Sousa Oliveira, Wilma Aparecida Starke-Buzetti
This study was about a semi-quantitative analysis of T lymphocytes (CD4+ and CD8+, FoxP3+ regulatory T cells), and macrophages in the gut wall of dogs naturally infected with Leishmania infantum. Thirteen dogs were divided into three groups: group 1 (G1, n=5), dogs with canine visceral leishmaniasis (CVL) and infected with L. infantum amastigotes in the intestine; group 2 (G2, n=5), dogs with CVL but without intestinal amastigotes; and group 3 (G3, n=3), uninfected dogs (control group). There was no significant difference (p ≥ 0...
April 2017: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/28740945/quality-of-life-of-patients-with-metabolic-syndrome-is-improved-after-whole-body-vibration-exercises
#16
RANDOMIZED CONTROLLED TRIAL
Rafaelle Pacheco Carvalho-Lima, Danúbia C Sá-Caputo, Eloá Moreira-Marconi, Carla Dionello, Laisa Liane Paineiras-Domingos, Cintia Renata Sousa-Gonçalves, Daniele Soares Morel, Eric Heleno Frederico, Mario F Neves, Ricardo Oliveira, Wille Oigman, Pedro J Marin, Dulciane N Paiva, Mario Bernardo-Filho
BACKGROUND: Whole body vibration exercises (WBVE) improve the quality of life (QoL) of different populations. Metabolic syndrome patients (MetS) may be favored by physical activity. Questionnaires are used to assess the QoL. The aim was to evaluate the QoL of patients with MetS that have undergone WBVE with a brief WHOQOL (WHOQOL-BREF). MATERIAL AND METHODS: MetS patients were randomly divided into three groups: (i) control group (CG), (ii) treated with WBVE once per week (WBVE1) and (iii) treated with WBVE twice per week (WBVE2)...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28740943/potential-effects-of-whole-body-vibration-exercises-on-blood-flow-kinetics-of-different-populations-a-systematic-review-with-a-suitable-approach
#17
REVIEW
Danúbia Sá-Caputo, Laisa Paineiras-Domingos, Rafaelle Carvalho-Lima, Glenda Dias-Costa, Patrícia de Castro de Paiva, Claudia Figueiredo de Azeredo, Roberto Carlos Resende Carmo, Carla F Dionello, Eloá Moreira-Marconi, Éric Heleno F F Frederico, Cintia Renata Sousa-Gonçalves, Danielle S Morel, Dulciane N Paiva, Núbia C P Avelar, Ana C Lacerda, Carlos E V Magalhães, Leonardo S Castro, Giuseppe A Presta, Severo de Paoli, Borja Sañudo, Mario Bernardo-Filho
BACKGROUND: The ability to control skin blood flow decreases with advancing age and some clinical disorders, as in diabetes and in rheumatologic diseases. Feasible clinical strategies such as whole-body vibration exercise (WBVE) are being used without a clear understanding of its effects. The aim of the present study is to review the effects of the WBVE on blood flow kinetics and its feasibility in different populations. MATERIAL AND METHODS: The level of evidence (LE) of selected papers in PubMed and/or PEDRo databases was determined...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28724023/-maternal-depressive-symptoms-and-anxiety-and-interference-in-the-mother-child-relationship-based-on-a-prenatal-cohort-an-approach-with-structural-equations-modeling
#18
Adriana Oliveira Dias de Sousa Morais, Vanda Maria Ferreira Simões, Lívia Dos Santos Rodrigues, Rosângela Fernandes Lucena Batista, Zeni Carvalho Lamy, Carolina Abreu de Carvalho, Antônio Augusto Moura da Silva, Marizélia Rodrigues Costa Ribeiro
This study aimed to investigate the association between maternal depressive symptoms and anxiety and interference in the mother/child relationship, using structural equations modeling. Data were used from a prospective cohort study initiated during the prenatal period with 1,140 mothers in São Luís, Maranhão State, Brazil. Data were collected during prenatal care and when the children reached two years of age. Interference in the mother/child relationship was measured with the Postpartum Bonding Questionnaire - PBQ (N = 1,140)...
July 13, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28713308/predictive-relation-between-early-numerical-competencies-and-mathematics-achievement-in-first-grade-portuguese-children
#19
Lilia Marcelino, Óscar de Sousa, António Lopes
Early numerical competencies (ENC) (counting, number relations, and basic arithmetic operations) have a central position in the initial learning of mathematics, and their assessment is useful for predicting later mathematics achievement. Using a regression model, this study aims to analyze the correlational and predictive evidence between ENC and mathematics achievement in first grade Portuguese children (n = 123). The children's ENC were examined at the point of school entry. Three criterion groups (low, moderate, and high ENC) were formed based on the results of the early numerical brief screener and mathematics achievement measured at the end of first grade...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28705595/excretory-secretory-antigens-of-strongyloides-venezuelensis-applied-to-igg-detection-in-human-strongyloidosis
#20
Renata A Cunha, Edson F G de Carvalho, José E N de Sousa, Julia M Costa-Cruz
Strongyloidosis is a neglected disease that affects millions of people around the world. The cases that particularly deserve attention are those related to hyperinfection, mainly in immunocompromised patients. In this sense, there is a need to improve the serological diagnosis of this helminth. The objective of this study was therefore to produce and characterize excretory/secretory (E/S) antigens of Strongyloides venezuelensis infective larvae (L3) for use as a heterologous antigen in the diagnosis of human strongyloidosis and other parasitic infection groups...
July 10, 2017: Parasitology International
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