Nopakorn Hansanant, Kevin Cao, Abraham Tenorio, Thushinari Joseph, Min Ju, Noah McNally, Evangel Kummari, McKinley Williams, Andrew Cothrell, Andrew R Buhrow, Ronald Shin, Ravi Orugunty, Leif Smith
The rise of multidrug resistant fungal infections highlights the need to identify and develop novel antifungal agents. Occidiofungin is a nonribosomally synthesized glycolipopeptide that has a unique mechanism of action, disrupting actin-mediated functions and inducing cellular apoptosis. Antifungal activity has been observed in vitro against various fungal species, including multidrug resistant Candida auris , and in vivo efficacy has been demonstrated in a murine vulvovaginal candidiasis model. Occidiofungin, a cyclic glycolipopeptide, is composed of eight amino acids and in previous studies, an asparagine residue was assigned at position 7 (ASN7)...
January 26, 2024: Journal of Natural Products