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https://www.readbyqxmd.com/read/29330347/performance-of-candidates-disclosing-dyslexia-with-other-candidates-in-a-uk-medical-licensing-examination-cross-sectional-study
#1
Zahid B Asghar, Aloysius Niroshan Siriwardena, Chris Elfes, Jo Richardson, James Larcombe, Katherine A Neden, Amer Salim, David Smalley, Carol Blow
PURPOSE OF THE STUDY: The aim of this study was to compare performance of candidates who declared an expert-confirmed diagnosis of dyslexia with all other candidates in the Applied Knowledge Test (AKT) of the Membership of the Royal College of General Practitioners licensing examination. STUDY DESIGN: We used routinely collected data from candidates who took the AKT on one or more occasions between 2010 and 2015. Multivariate logistic regression was used to analyse performance of candidates who declared dyslexia with all other candidates, adjusting for candidate characteristics known to be associated with examination success including age, sex, ethnicity, country of primary medical qualification, stage of training, number of attempts and time spent completing the test...
January 12, 2018: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29329964/is-quality-of-registry-treatment-data-related-to-registrar-experience-and-workload-a-study-of-taiwan-cancer-registry-data
#2
Chin-Ying Cheng, Chun-Ju Chiang, Cheng-Hsing Hsieh, You-Kang Chang, Mei-Shu Lai
BACKGROUND: Although cancer treatment information has been collected through the Cancer Registry system in Taiwan for more than 10 years, the accuracy of such data has never been evaluated. This study examined the accuracy rate between registrar experience and on-site chart review for the first course of cancer treatment. METHODS: In this retrospective chart review study, 392 randomly selected medical records from 14 hospitals were re-abstracted by experienced abstractors...
January 10, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29324253/a-qualitative-study-comparing-physician-reported-barriers-to-treating-addiction-using-buprenorphine-and-extended-release-naltrexone-in-u-s-office-based-practices
#3
Barbara Andraka-Christou, Matthew J Capone
AIM: Our aim was to compare physician-reported barriers to sublingual buprenorphine (BUP) and extended-release naltrexone (XR-NLT) prescribing in U.S. office-based practices, and to identify potential policies for minimizing these barriers. Only one previous qualitative study has examined physician-reported barriers to prescribing XR-NLT and no qualitative study has compared physician-reported barriers between the two medications. METHODS: Researchers conducted individual semi-structured and in-depth interviews with 20 licensed physicians in four U...
January 8, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29319597/repeated-same-day-versus-single-tomography-measurements-of-keratoconic-eyes-for-analysis-of-disease-progression
#4
Wolf Wonneberger, Bertil Sterner, Ulrika MacLean, Margareta Claesson, Madeleine Zetterberg
PURPOSE: Corneal tomography is used to assess progression of keratoconus and to direct clinical decisions regarding corneal cross-linking. The purpose of this study was to analyze the variability of repeated Scheimpflug-tomography (Pentacam Classic; Oculus, Wetzlar, Germany) measurements of keratoconic eyes in a clinical setting and to assess the validity of such measurements as a clinical decision-making tool. METHODS: Eighty keratoconic eyes of 45 patients (age range 16-32 years) were examined at baseline and after follow-up periods of 3 to 6 months using 3 consecutive tomography measurements at each visit...
January 9, 2018: Cornea
https://www.readbyqxmd.com/read/29319585/which-us-states-pose-the-greatest-threats-to-military-readiness-and-public-health-public-health-policy-implications-for-a-cross-sectional-investigation-of-cardiorespiratory-fitness-body-mass-index-and-injuries-among-us-army-recruits
#5
Daniel B Bornstein, George L Grieve, Morgan N Clennin, Alexander C McLain, Laurie P Whitsel, Michael W Beets, Keith G Hauret, Bruce H Jones, Mark A Sarzynski
OBJECTIVE: Many states in the southern region of the United States are recognized for higher rates of obesity, physical inactivity, and chronic disease. These states are therefore recognized for their disproportionate public health burden. The purpose of this study was to investigate state-level distributions of cardiorespiratory fitness, body mass index (BMI), and injuries among US Army recruits in order to determine whether or not certain states may also pose disproportionate threats to military readiness and national security...
January 9, 2018: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29318106/pneumococcal-vaccination-in-older-persons-where-are-we-today
#6
REVIEW
Paul Van Buynder, Robert Booy
Disease due to Streptococcus pneumoniae, the pneumococcus, remains a major source of illness in older persons. Globally, it remains the most important pathogen in respiratory infection deaths. Conjugated pneumococcal vaccines are used extensively in national pediatric programs, whereas a polysaccharide vaccine is used in all age groups, but mainly in the elderly and for high-risk groups. Recent data from the Netherlands led to the licensing in many countries of conjugated pneumococcal vaccines for older persons...
2018: Pneumonia
https://www.readbyqxmd.com/read/29311441/yellow-tongue-coating-is-associated-with-diabetes-mellitus-among-japanese-non-smoking-men-and-women-the-toon-health-study
#7
Kiyohide Tomooka, Isao Saito, Shinya Furukawa, Koutatsu Maruyama, Eri Eguchi, Hiroyasu Iso, Takeshi Tanigawa
BACKGROUND: Yellow tongue coating is one of the clinical signs for diabetes mellitus according to traditional East Asian medicine. Few reports have been available on the association between yellow tongue coating and the prevalence of type 2 diabetes in the general population. We examined that association among population samples of non-smoking men and women. METHODS: The study subjects were Japanese non-smoking men (n = 315) and women (n = 654) aged 30-79 years who resided in Toon city and participated in the Toon Health Study from July 2011 through November 2014...
December 28, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/29303911/histone-deacetylase-inhibition-restores-expression-of-hypoxia-inducible-protein-ndrg1-in-pancreatic-cancer
#8
Céline Tiffon
OBJECTIVES: N-myc downstream-regulated gene-1 (NDRG1) is a hypoxia-inducible and differentiation-related protein and candidate biomarker in pancreatic cancer. As NDRG1 expression is lost in high-grade tumors, the effects of the differentiating histone deacetylase inhibitor trichostatin A (TSA) were examined in human pancreatic cancer cell lines representing different tumor grades. METHODS: PANC-1 (poorly differentiated) and Capan-1 (moderately to well differentiated) cells were treated with TSA...
January 5, 2018: Pancreas
https://www.readbyqxmd.com/read/29302227/treatment-of-opioid-dependence-with-buprenorphine-current-update
#9
Michael Soyka
Opioid maintenance treatment is the first-line approach in opioid dependence. Both the full opioid agonist methadone (MET) and the partial agonist buprenorphine (BUP) are licensed for the treatment of opioid dependence. BUP differs significantly from MET in its pharmacology, side effects, and safety issues. For example, the risk of respiratory depression is lower than with MET. The risk of diversion and injection of BUP have been reduced by also making it available as a tablet containing the opioid antagonist naloxone...
September 2017: Dialogues in Clinical Neuroscience
https://www.readbyqxmd.com/read/29299984/biologic-therapy-in-psoriasis-part-ii-efficacy-and-safety-of-new-treatment-targeting-il23-il-17-pathways
#10
E Molinelli, A Campanati, Giulia Ganzetti, V Brisigotti, A Offidani
BACKGROUND: Psoriasis is a chronic immune-mediated inflammatory skin disorder that is estimated to affect 2-3% of the general population. The IL-23/IL-17 axis is currently considered to be crucial in the pathogenesis of psoriasis. METHODS: Biologics licensed for psoriasis include the TNFα inhibitors (infliximab, adalimumab, etanercept), the interleukin (IL)-12/23 monoclonal antibody (ustekinumab), and IL-17 inhibitor (secukinumab, ixekizumab). RESULTS: In this section, we analyse the role of IL-12, IL-23, and IL-17 in psoriasis and evaluated the efficacy and safety of biologic therapies targeting this cytokine...
January 3, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29299883/-epidemiological-study-on-the-visual-ability-of-official-public-transport-drivers-in-bamako
#11
O Diallo, L Traoré, F Traoré, A Simaga, J P Thera, B Coulibaly, M Diarra, M Sidibé, J Traoré, F N'Diaye
The aim of this work was to evaluate the public transport drivers' visual driving ability in Bamako. We carried out a descriptive cross-sectional study from May 15 to July 15, 2013. The probabilistic method was used. 385 drivers were examined at the University Hospital of the Institute of Tropical Ophthalmology of Africa (IOTA). The average age was 44.69 years. 296 drivers (76.9%) were able to drive public transport vehicles. Among drivers over 50 years old, 42.5% are unfit for driving. Color vision was normal in 98...
December 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/29298171/expression-of-%C3%AE-v-tubulin-in-secretory-cells-of-the-fallopian-tube-epithelium-marks-cellular-atypia
#12
Deepti Mathew, Yanhua Wang, Anne Van Arsdale, Susan Band Horwitz, Hayley McDaid
OBJECTIVES: Class V Beta tubulin isotype (βV-tubulin) was recently found to have tissue-specific expression patterns in epithelial tissues with secretory function and aberrant expression in tumors. The aims of this pilot study were (a) to examine expression of βV-tubulin in the fallopian tube epithelium (FTE) of patients who underwent salpingectomy, (b) to characterize FTE atypia in high-risk patients with BRCA mutations, and (c) to determine expression of βV-tubulin in serous ovarian neoplasms...
January 3, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29298168/incidence-of-cystoid-macular-edema-after-descemet-membrane-endothelial-keratoplasty
#13
Viridiana Kocaba, Romain Mouchel, Jacques Fleury, Anne-Sophie Marty, Hélène Janin-Manificat, Delphine Maucort-Boulch, Carole Burillon
PURPOSE: The incidence of and risk factors for cystoid macular edema (CME) after Descemet membrane endothelial keratoplasty (DMEK) remain uncertain. This study examines the incidence of and risk factors for CME after DMEK. METHODS: This retrospective, single-center study included patients with no history of CME who had undergone DMEK. Patients were examined weekly for 1 month after surgery and at 3 and 6 months after surgery. Follow-up examinations included visual acuity (VA) assessment, pachymetry, anterior segment optical coherence tomography, biomicroscopy, intraocular pressure measurement, and fundoscopy...
January 2, 2018: Cornea
https://www.readbyqxmd.com/read/29297750/a-d-alanine-auxotrophic-live-vaccine-is-effective-against-lethal-infection-caused-by-staphylococcus-aureus
#14
Miriam Moscoso, Patricia García, Maria P Cabral, Carlos Rumbo, Germán Bou
Staphylococcus aureus infections are becoming a major global health issue due to the rapid emergence of multidrug-resistant strains. Therefore, there is an urgent need to develop an effective vaccine to prevent and control these infections. In order to develop a universal immunization strategy, we constructed a mutant derivative of S. aureus 132 which lacks the genes involved in D-alanine biosynthesis, a structural component of cell wall peptidoglycan. This unmarked deletion mutant requires the exogenous addition of D-alanine for in vitro growth...
January 3, 2018: Virulence
https://www.readbyqxmd.com/read/29286952/prevalence-of-meibomian-gland-atrophy-in-a-pediatric-population
#15
Preeya K Gupta, Madelyn N Stevens, Namita Kashyap, Yos Priestley
PURPOSE: To report the prevalence of meibomian gland atrophy and gland tortuosity in a pediatric population. METHODS: Participants who presented with no history of dry eye disease or meibomian gland dysfunction were recruited from the Duke University Eye Center. Meibography was performed and subjective symptoms were assessed through the Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire. Grading of images was assessed by a masked rater using a previously validated 5-point meiboscale (0-4) for gland atrophy and a 3-point scale for gland tortuosity (0-2)...
December 27, 2017: Cornea
https://www.readbyqxmd.com/read/29285488/comparative-effectiveness-and-safety-of-empagliflozin-on-cardiovascular-mortality-and-morbidity-in-adults-with-type-2-diabetes
#16
Wilbert S Aronow, Tatyana A Shamliyan
Background: Based on a single placebo-controlled randomized clinical trial, empagliflozin is licensed to reduce cardiovascular death in diabetes and comorbid cardiovascular disease. Methods: We examined the comparative effectiveness of empagliflozin on mortality and cardiovascular morbidity in type 2 diabetes. We conducted random-effects direct frequentist meta-analyses of aggregate data and appraised the quality of evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology...
December 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29282462/evaluation-of-validity-evidence-for-personality-emotional-intelligence-and-situational-judgment-tests-to-identify-successful-residents
#17
Aimee K Gardner, Brian J Dunkin
Importance: The ability to identify candidates who will thrive and successfully complete their residency is especially critical for general surgery programs. Objective: To assess the extent to which 3 screening tools used extensively in industrial selection settings-emotional intelligence (EQ), personality profiles, and situational judgment tests (SJTs)-could identify successful surgery residents. Design, Setting, and Participants: In this analysis, personality profiles, EQ assessments, and SJTs were administered from July through August 2015 to 51 postgraduate year 1 through 5 general surgery residents in a large general surgery residency program...
December 27, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29280773/work-engagement-productivity-and-self-reported-work-related-sedentary-behavior-among-japanese-adults-a-cross-sectional-study
#18
Kaori Ishii, Ai Shibata, Koichiro Oka
OBJECTIVE: To examine the relationships between work engagement, productivity, and self-reported work-related sedentary behavior in Japanese adults. METHODS: The present study recruited 2,572 Japanese individuals (20-59 years old) via an internet survey and assessed their demographic characteristics, work-related characteristics, and sedentary behavior. Data were analyzed with logistic regression. RESULTS: The mean proportion of work days involving work-related sedentary behavior was approximately 70% and the mean number of weekly working hours was approximately 43 hours...
December 26, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29280725/men-in-occupational-therapy-issues-factors-and-perceptions
#19
Angelo J M Maxim, Martin S Rice
OBJECTIVE: Relatively few men are occupational therapy practitioners in the United States. Little research has examined issues germane to men working in the profession. The objective of this study was to investigate perceptions, issues, and factors surrounding male occupational therapy practitioners. METHOD: A survey link was emailed to 9,467 licensed occupational therapy practitioners in Ohio; 699 participants responded, yielding a response rate of 7.66%. RESULTS: Male and female participants provided both similar and significantly different responses to the survey questions...
January 2018: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/29278904/usefulness-of-detect-program-to-assess-internal-structure-of-dimensionality-in-simulated-data-and-results-of-korean-nursing-licensing-examination
#20
Dong Gi Seo, Younyoung Choi, Sun Huh
Purpose: The dimensionality of examinations provides empirical evidence to investigate the internal test structure underlying the responses to a set of items. The internal structure is one of the important evidence to demonstrate examination validity sources. Thus, aim of the study is to examine the internal structure of Korean nursing examinations and investigate performances of DETECT program. Methods: Non-parametric methods such as DETECT program have proposed to overcome the limitation of traditional parametric methods as a dimensional testing method...
December 27, 2017: Journal of Educational Evaluation for Health Professions
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