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https://www.readbyqxmd.com/read/28430700/prescriber-compliance-with-liver-monitoring-guidelines-for-pazopanib-in-the-postapproval-setting-results-from-a-distributed-research-network
#1
Sumitra Shantakumar, Beth L Nordstrom, Susan A Hall, Luc Djousse, Myrthe P P van Herk-Sukel, Kathy H Fraeman, David R Gagnon, Karen Chagin, Jeanenne J Nelson
OBJECTIVES: Pazopanib received US Food and Drug Administration approval in 2009 for advanced renal cell carcinoma. During clinical development, liver chemistry abnormalities and adverse hepatic events were observed, leading to a boxed warning for hepatotoxicity and detailed label prescriber guidelines for liver monitoring. As part of postapproval regulatory commitments, a cohort study was conducted to assess prescriber compliance with liver monitoring guidelines. METHODS: Over a 4-year period, a distributed network approach was used across 3 databases: US Veterans Affairs Healthcare System, a US outpatient oncology community practice database, and the Dutch PHARMO Database Network...
April 20, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28427508/review-of-current-evidence-available-for-guiding-optimal-enoxaparin-prophylactic-dosing-strategies-in-obese-patients-actual-weight-based-vs-fixed
#2
REVIEW
Zikai He, Hana Morrissey, Patrick Ball
BACKGROUND: The current debate over the optimal Enoxaparin prophylactic dosing strategies in obese patients centre around whether it should be based on the actual weight of the patient (i.e. weight-based), or at an artificially fixed amount, as it is the case in Australia (40mg daily). The vast majority of the evidence available today is laboratory-based, measuring serum Antifactor-Xa activities as a marker for physiological response. AIM: The aim of the parent study is to compare the clinical outcomes for obese patients who received fixed doses of enoxaparin compared to those who received weight-based doses within the licensed dosage recommendations...
May 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28426318/us-state-statutes-banning-powdered-alcohol-exceptions-and-penalties
#3
Andrea M Garcia
To examine state statutes banning powdered alcohol, we identified relevant statutes in all 50 states and the District of Columbia through a search (initial search March 2016; follow-up search November 2016) using the legal research database LexisNexis. To identify the laws, we used the following search terms: "concentrated alcohol," "crystalline alcohol," "granulated alcohol," "palcohol," and "powdered alcohol." As of November 2016, 31 states had statutory bans on powdered alcohol. Statutes in 22 states outline penalties for violating the state's ban on powdered alcohol...
April 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28423928/engaging-parents-to-promote-children-s-nutrition-and-health
#4
Dipti A Dev, Courtney Byrd-Williams, Samantha Ramsay, Brent McBride, Deepa Srivastava, Ashleigh Murriel, Chrisa Arcan, Anna M Adachi-Mejia
PURPOSE: Using the Academy of Nutrition and Dietetics benchmarks as a framework, this study examined childcare providers' (Head Start [HS], Child and Adult Care Food Program [CACFP] funded, and non-CACFP) perspectives regarding communicating with parents about nutrition to promote children's health. DESIGN: Qualitative. SETTING: State-licensed center-based childcare programs. PARTICIPANTS: Full-time childcare providers (n = 18) caring for children 2 to 5 years old from varying childcare contexts (HS, CACFP funded, and non-CACFP), race, education, and years of experience...
March 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/28422816/why-not-wait-eight-institutions-share-their-experiences-moving-united-states-medical-licensing-examination-step-1-after-core-clinical-clerkships
#5
Michelle Daniel, Amy Fleming, Colleen O'Conner Grochowski, Vicky Harnik, Sibel Klimstra, Gail Morrison, Arnyce Pock, Michael L Schwartz, Sally Santen
The majority of medical students complete the United States Medical Licensing Examination Step 1 after their foundational sciences; however, there are compelling reasons to examine this practice. This article provides the perspectives of eight MD-granting medical schools that have moved Step 1 after the core clerkships, describing their rationale, logistics of the change, outcomes, and lessons learned. The primary reasons these institutions cite for moving Step 1 after clerkships are to foster more enduring and integrated basic science learning connected to clinical care and to better prepare students for the increasingly clinical focus of Step 1...
April 18, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28419068/visual-improvements-in-vaginal-mucosa-correlate-with-symptoms-of-vva-data-from-a-double-blind-placebo-controlled-trial
#6
James A Simon, David F Archer, Risa Kagan, Brian Bernick, Shelli Graham, Ginger D Constantine, Sebastian Mirkin
OBJECTIVE: To evaluate the response of the vaginal mucosa with TX-004HR and its correlation with vulvar and vaginal atrophy (VVA) symptoms, and whether visual examination is a useful measure for assessing VVA. METHODS: REJOICE was a 12-week, phase 3, multicenter, randomized, double-blind, placebo-controlled study of a vaginal, muco-adhesive, 17β-estradiol softgel capsule (TX-004HR 4, 10, and 25 μg) in postmenopausal women with VVA and moderate-to-severe dyspareunia...
April 17, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28418777/er-la-opioid-rems-and-accredited-education-survey-results-provide-insight-into-clinical-roles-educational-needs-and-learner-preferences
#7
Cynthia Kear, Tom McKeithen, Sheila Robertson
BACKGROUND: The Collaborative for REMS Education (CO*RE) includes 13 organizations who provide REMS Program Companies (RPC) grant-supported accredited education on extended-release and long-acting (ER/LA) opioid therapy. This report summarizes results of a survey designed to investigate the impact of participant criteria and to better understand the roles and preferences of CME/CE participants. METHODS: In April 2015, we made an online survey available to an estimated 10,000 clinicians who had completed a CO*RE CME/CE activity since 2013...
April 18, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28418270/usmle-and-otolaryngology-predicting-board-performance
#8
Liana Puscas, David Chang, Hui-Jie Lee, Rodney Diaz, Robert Miller
Objective To ascertain what relationship exists between the United States Medical Licensing Examination (USMLE) and the American Board of Otolaryngology Written Qualifying Examination (WQE). Study Design Retrospective, longitudinal study. Setting De-identified database. Subjects Residents entering otolaryngology-head and neck surgery (OHNS) residency between 2007 and 2009 and taking the WQE for the first time between 2012 and 2014. Methods Regression models were used to determine if the USMLE score predicts passage of the WQE on the first attempt, which step score was a better predictor, and whether an increase in the Step 2 score increased the chances of WQE passage...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28410356/water-exposure-is-a-common-risk-behavior-among-soft-and-gas-permeable-contact-lens-wearers
#9
Aaron B Zimmerman, Kathryn Richdale, Gladys Lynn Mitchell, Beth T Kinoshita, Dawn Y Lam, Heidi Wagner, Luigina Sorbara, Robin L Chalmers, Sarah A Collier, Jennifer R Cope, Maya M Rao, Michael J Beach, Jonathan S Yoder
PURPOSE: To understand soft contact lens (SCL) and gas-permeable (GP) lens wearers' behaviors and knowledge regarding exposure of lenses to water. METHODS: The Contact Lens Risk Survey (CLRS) and health behavior questions were completed online by a convenience sample of 1056 SCL and 85 GP lens wearers aged 20 to 76 years. Participants were asked about exposing their lenses to water and their understanding of risks associated with these behaviors. Chi-square analyses examined relationships between patient behaviors and perceptions...
April 13, 2017: Cornea
https://www.readbyqxmd.com/read/28399063/language-outcomes-in-deaf-or-hard-of-hearing-teenagers-who-are-spoken-language-users-effects-of-universal-newborn-hearing-screening-and-early-confirmation
#10
Hannah Pimperton, Jana Kreppner, Merle Mahon, Jim Stevenson, Emmanouela Terlektsi, Sarah Worsfold, Ho Ming Yuen, Colin R Kennedy
OBJECTIVES: This study aimed to examine whether (a) exposure to universal newborn hearing screening (UNHS) and b) early confirmation of hearing loss were associated with benefits to expressive and receptive language outcomes in the teenage years for a cohort of spoken language users. It also aimed to determine whether either of these two variables was associated with benefits to relative language gain from middle childhood to adolescence within this cohort. DESIGN: The participants were drawn from a prospective cohort study of a population sample of children with bilateral permanent childhood hearing loss, who varied in their exposure to UNHS and who had previously had their language skills assessed at 6-10 years...
April 10, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28398945/objective-measures-of-physical-activity-and-cardiometabolic-and-endocrine-biomarkers
#11
Hala B AlEssa, Andrea K Chomistek, Susan E Hankinson, Junaidah B Barnett, Jennifer Rood, Charles E Matthews, Eric B Rimm, Walter C Willett, Frank B Hu, Deirdre K Tobias
PURPOSE: Although physical activity is an established risk factor for chronic disease prevention, the specific mechanisms underlying these relationships are poorly understood. We examined the associations between total activity counts (TAC) and moderate-vigorous physical activity (MVPA) measured by accelerometer, and physical activity energy expenditure (PAEE) measured by doubly-labeled water, with plasma levels of pro-insulin, insulin, c-peptide, IGFBP-3, IGF-1, adiponectin, leptin and leptin-sR...
April 11, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28396468/a-review-of-phase-i-trials-of-ebola-virus-vaccines-what-can-we-learn-from-the-race-to-develop-novel-vaccines
#12
REVIEW
Teresa Lambe, Georgina Bowyer, Katie J Ewer
Sporadic outbreaks of Ebola virus infection have been documented since the mid-Seventies and viral exposure can lead to lethal haemorrhagic fever with case fatalities as high as 90%. There is now a comprehensive body of data from both ongoing and completed clinical trials assessing various vaccine strategies, which were rapidly advanced through clinical trials in response to the 2013-2016 Ebola virus disease (EVD) public health emergency. Careful consideration of immunogenicity post vaccination is essential but has been somewhat stifled because of the wide array of immunological assays and outputs that have been used in the numerous clinical trials...
May 26, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28395697/psychometric-properties-of-the-extended-nursing-stress-scale-measuring-stress-in-workplace
#13
Muder Alkrisat, Manal Alatrash
BACKGROUND: Despite its popularity, the psychometric properties of the Extended Nursing Stress Scale (ENSS) in working adults are yet to be evaluated in different settings. METHODS: This study examined the ENSS in acute care settings among licensed nurses through a questionnaire survey. The sample responses were examined using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). RESULTS: A response rate of 37% was achieved; 199 licensed nurses completed the questionnaire...
April 1, 2017: Journal of Nursing Measurement
https://www.readbyqxmd.com/read/28392971/the-occurrence-and-traumatic-impact-of-sexual-revictimization-in-newlywed-couples
#14
David DiLillo, Anna E Jaffe, Laura E Watkins, James Peugh, Amanda Kras, Christopher Campbell
The present study examines whether individuals with a history of child sexual abuse are at risk of sexual revictimization in marriage and, if so, whether these experiences are associated with increased trauma symptomatology. Two hundred heterosexual newlywed couples were recruited from marriage license records and completed self-report assessments of past sexual victimization and sexual coercion within the marital dyad. Actor-Partner Interdependence Models revealed that, compared to non-victims, women with a history of child sexual abuse (CSA) experienced more acts of sexual coercion by their husbands during the past year...
December 2016: Couple & Family Psychology
https://www.readbyqxmd.com/read/28391092/survival-pattern-of-first-accident-among-commercial-drivers-in-the-greater-accra-region-of-ghana
#15
Salifu Nanga, Nii Afotey Odai, Anani Lotsi
In this study, the average accident risk of commercial drivers in the Greater Accra region of Ghana and its associated risks were examined based on a survey data collected using paper-based questionnaires from 204 commercial drivers from the Greater Accra Region of Ghana. The Cox Proportional Hazards Model was used for multivariate analysis while the Kaplan-Meier (KM) Model was used to study the survival patterns of the commercial drivers. The study revealed that the median survival time for an accident to happen is 2...
April 6, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28383362/aripiprazole-once-monthly-in-the-treatment-of-acute-psychotic-episodes-in-schizophrenia-post-hoc-analysis-of-positive-and-negative-syndrome-scale-marder-factor-scores
#16
Zahinoor Ismail, Timothy Peters-Strickland, Maia Miguelez, Ross A Baker, Peter Hertel, Anna Eramo, Na Jin, Pamela Perry, Raymond Sanchez, Robert D McQuade, John M Kane
BACKGROUND: Long-acting injectable antipsychotics are treatment options for acute and long-term treatment of patients with schizophrenia. In a previously published 12-week randomized, double-blind, placebo-controlled clinical trial of patients with schizophrenia experiencing an acute psychotic episode, aripiprazole once-monthly 400 mg (AOM 400) produced significantly greater improvement than placebo on the primary endpoint, Positive and Negative Syndrome Scale (PANSS) total score at week 10...
June 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28383345/availability-of-foodborne-illness-reporting-mechanisms-for-the-public-on-local-health-department-web-sites
#17
Jenine K Harris, Roger Wong, Megan G Matthew, Raed Mansour
CONTEXT: Foodborne illness is a serious and preventable public health problem, with high health and economic tolls in the United States. Local governments play an important role in food safety, with local health departments (LHDs) responsible for licensing and inspecting restaurants. Foodborne illness complaints from the public result in identification of more serious and critical food safety violations than regularly scheduled inspections; however, few people report foodborne illness...
April 4, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28383325/effectiveness-of-written-and-oral-specialty-certification-examinations-to-predict-actions-against-the-medical-licenses-of-anesthesiologists
#18
Yan Zhou, Huaping Sun, Deborah J Culley, Aaron Young, Ann E Harman, David O Warner
BACKGROUND: The American Board of Anesthesiology administers written and oral examinations for its primary certification. This retrospective cohort study tested the hypothesis that the risk of a disciplinary action against a physician's medical license is lower in those who pass both examinations than those who pass only the written examination. METHODS: Physicians who entered anesthesiology training from 1971 to 2011 were followed up to 2014. License actions were ascertained via the Disciplinary Action Notification Service of the Federation of State Medical Boards...
April 6, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28382713/ultra-small-superparamagnetic-iron-oxides-for-metastatic-lymph-node-detection-back-on-the-block
#19
REVIEW
Ansje S Fortuin, Roger Brüggemann, Janine van der Linden, Ilia Panfilov, Bas Israël, Tom W J Scheenen, Jelle O Barentsz
In the past 15 years, encouraging clinical results for the detection of small lymph node metastases was obtained by the use of Combidex-enhanced MRI (CEM, also known as magnetic resonance lymphography). Withdrawal of the European Medicines Agency approval application by the manufacturer made it impossible for patients to benefit from this agent; a loss, especially for men with prostate cancer. Current conventional imaging techniques are not as accurate as CEM is, thus a surgical diagnostic exploration (extended lymph node dissection) is still the preferred technique to evaluate the lymph nodes, resulting in peri- and postoperative complications...
April 6, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28378439/social-outcomes-of-young-adults-with-childhood-onset-epilepsy-a-case-sibling-control-study
#20
Christine B Baca, Frances Barry, Barbara G Vickrey, Rochelle Caplan, Anne T Berg
OBJECTIVE: We aimed to compare long-term social outcomes in young adults with childhood-onset epilepsy (cases) with neurologically normal sibling controls. METHODS: Long-term social outcomes were assessed at the 15-year follow-up of the Connecticut Study of Epilepsy, a community-based prospective cohort study of children with newly diagnosed epilepsy. Young adults with childhood-onset epilepsy with complicated (abnormal neurologic exam findings, abnormal brain imaging with lesion referable to epilepsy, intellectual disability (ID; IQ < 60) or informative history of neurologic insults to which the occurrence of epilepsy might be attributed), and uncomplicated epilepsy presentations were compared to healthy sibling controls...
April 4, 2017: Epilepsia
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