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PET-CT lung cancer

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https://www.readbyqxmd.com/read/28072730/bortezomib-combined-with-lenalidomide-as-the-first-line-treatment-for-the-rare-synchronous-occurrence-of-multiple-myeloma-and-pulmonary-adenocarcinoma-a-case-report
#1
Wenli Zuo, Xinghu Zhu, Jingke Yang, Zhenyang Mei, Mei Deng, Quande Lin, Yongping Song, Qingsong Yin
BACKGROUND: Simultaneous multiple myeloma (MM) and pulmonary adenocarcinoma is a rare occurrence, and thus, treatment is a challenge. This study reports on 1 such case of MM with concurrent lung cancer, where an accurate diagnosis was made and the patient underwent treatment for both cancers. CASE SUMMARY: A 68-year-old man presented with 2 months of progressive lower back pain. Visualization with magnetic resonance imaging (MRI) revealed multiple collapsed vertebrae from T12 to S3, as well as an altered signal intensity at the T3 vertebra...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28058562/effectiveness-of-repeat-18f-fluorodeoxyglucose-positron-emission-tomography-computerized-tomography-pet-ct-scan-in-identifying-interval-metastases-for-patients-with-esophageal-cancer
#2
Emmanuel Gabriel, Raed Alnaji, William Du, Kristopher Attwood, Moshim Kukar, Steven Hochwald
INTRODUCTION: An 18F-fluorodeoxyglucose positron emission tomography-computerized tomography (PET-CT) scan is performed after neoadjuvant chemoradiation (nCRT) to restage esophageal cancer. The purpose of this study was to determine the ability of PET-CT to accurately identify interval metastatic disease following nCRT. METHODS: This was a single-institution retrospective review (January 2005-February 2012) of patients with esophageal cancer treated with nCRT who underwent pre- and post-nCRT PET-CT...
January 5, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28057034/the-predictive-value-of-18-f-fdg-pet-ct-for-assessing-the-clinical-outcomes-in-locally-advanced-nsclc-patients-after-a-new-induction-treatment-low-dose-fractionated-radiotherapy-with-concurrent-chemotherapy
#3
Maria Vittoria Mattoli, Mariangela Massaccesi, Alessandra Castelluccia, Valentina Scolozzi, Giovanna Mantini, Maria Lucia Calcagni
BACKGROUND: Patients with locally advanced non-small-cell lung cancer (LA-NSCLC) have poor prognosis despite several multimodal approaches. Recently, low-dose fractionated radiotherapy concurrent to the induction chemotherapy (IC-LDRT) has been proposed to further improve the effects of chemotherapy and prognosis. Until now, the predictive value of metabolic response after IC-LDRT has not yet been investigated. AIM: to evaluate whether the early metabolic response, assessed by (18)F-fluoro-deoxyglucose positron emission-computed tomography ((18)F-FDG PET-CT), could predict the prognosis in LA-NSCLC patients treated with a multimodal approach, including IC-LDRT...
January 5, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28048907/su-f-r-46-predicting-distant-failure-in-lung-sbrt-using-multi-objective-radiomics-model
#4
Z Zhou, M Folkert, P Iyengar, Y Zhang, J Wang
PURPOSE: To predict distant failure in lung stereotactic body radiation therapy (SBRT) in early stage non-small cell lung cancer (NSCLC) by using a new multi-objective radiomics model. METHODS: Currently, most available radiomics models use the overall accuracy as the objective function. However, due to data imbalance, a single object may not reflect the performance of a predictive model. Therefore, we developed a multi-objective radiomics model which considers both sensitivity and specificity as the objective functions simultaneously...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048894/su-f-i-58-image-quality-comparisons-of-different-motion-magnitudes-and-tr-values-in-mr-pet
#5
J Patrick, M Tavallaei, R Thompson, R Stodilka, M Drangova, S Gaede
PURPOSE: The aim of this work is to evaluate the accuracy and sensitivity of a respiratory-triggered MR-PET protocol in detecting four different sized lesions at two different magnitudes of motion, with two different TR values, using a novel PET-MR-CT compatible respiratory motion phantom. METHODS: The eight-compartment torso phantom was setup adjacent to the motion stage, which moved four spherical compartments (28, 22, 17, 10 mm diameter) in two separate (1 and 2 cm) linear motion profiles, simulating a 3...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048762/su-f-t-130-18f-fdg-uptake-dose-response-in-lung-correlates-linearly-with-proton-therapy-dose
#6
D Kim, U Titt, D Mirkovic
PURPOSE: Analysis of clinical outcomes in lung cancer patients treated with protons using 18F-FDG uptake in lung as a measure of dose response. METHODS: A test case lung cancer patient was selected in an unbiased way. The test patient's treatment planning and post treatment positron emission tomography (PET) were collected from picture archiving and communication system at the UT M.D. Anderson Cancer Center. Average computerized tomography scan was registered with post PET/CT through both rigid and deformable registrations for selected region of interest (ROI) via VelocityAI imaging informatics software...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048737/mo-de-207b-01-jack-fowler-junior-investigator-competition-winner-between-somatic-mutations-and-pet-based-radiomic-features-in-non-small-cell-lung-cancer
#7
S Yip, J Kim, T Coroller, E Rios Velazquez, C Parmar, R Mak, H Aerts
PURPOSE: Although PET-based radiomic features have been proposed to quantify tumor heterogeneity and shown promise in outcome prediction, little is known about their relationship with tumor genetics. This study assessed the association of [(18) F]fluorodeoxyglucose (FDG)-PET-based radiomic features with non-small cell lung cancer (NSCLC) mutations. METHODS: 348 NSCLC patients underwent FDG-PET/CT scans before treatment and were tested for genetic mutations. 13% (44/348) and 28% (96/348) patients were found to harbor EGFR (EGFR+) and KRAS (KRAS+) mutations, respectively...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048615/tu-h-202-04-the-vampire-challenge-preliminary-results-from-a-multi-institutional-study-of-ct-ventilation-image-accuracy
#8
J Kipritidis
: CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048597/tu-h-campus-iep3-01-simultaneous-pet-restoration-and-pet-ct-co-segmentation-using-a-variational-method
#9
L Li, W Lu, S Tan
PURPOSE: PET images are usually blurred due to the finite spatial resolution, while CT images suffer from low contrast. Segment a tumor from either a single PET or CT image is thus challenging. To make full use of the complementary information between PET and CT, we propose a novel variational method for simultaneous PET image restoration and PET/CT images co-segmentation. METHODS: The proposed model was constructed based on the Γ-convergence approximation of Mumford-Shah (MS) segmentation model for PET/CT co-segmentation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048559/we-ab-202-05-validation-of-lung-stress-maps-for-ct-ventilation-imaging
#10
G Cazoulat, J Kipritidis, S Siva, M Hofman, S Jolly, M Matuszak, J Balter, P Keall, K Brock
PURPOSE: To date, lung CT-ventilation imaging has been based on quantification of local breathing-induced changes in Hounsfield Units (HU) or volume. This work investigates the use of a stress map resulting from a biomechanical deformable image registration (DIR) algorithm as a metric of the ventilation function. METHOD: Eight lung cancer patients presenting different kinds of ventilation defects were retrospectively analyzed. Additionally, to the 4DCT acquired for radiotherapy planning, five of them had PET and three had SPECT imaging following inhalation of Ga-68 and Tc-99m, respectively...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048557/tu-h-202-00-ct-ventilation-imaging-the-new-clinical-reality-of-functional-avoidance-and-response-assessment-in-lung-cancer-radiation-therapy
#11
Paul Keall
: CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048524/su-f-t-356-dosimetriccomparison-of-vmat-vs-step-and-shoot-imrt-plans-for-stage-iii-lung-cancerpatients-with-mediastinal-involvement
#12
D Pearson, J Bogue
PURPOSE: For Stage III lung cancers that entail treatment of some or all of the mediastinum, anterior-posterior focused Step and Shoot IMRT (SS-IMRT) and VMAT plans have been clinically used to deliver the prescribed dose while working to minimize lung dose and avoid other critical structures. A comparison between the two planning methods was completed to see which treatment method is superior and minimizes dose to healthy lung tissue. METHODS: Ten patients who were recently treated with SS-IMRT or VMAT plans for Stage III lung cancer with mediastinal involvement were selected...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048314/su-d-204-07-retrospective-correlation-of-dose-accuracy-with-regions-of-local-failure-for-early-stage-lung-cancer-patients-treated-with-stereotactic-body-radiotherapy
#13
S Devpura, H Li, C Liu, C Fraser, M Ajlouni, B Movsas, I Chetty
PURPOSE: To correlate dose distributions computed using six algorithms for recurrent early stage non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT), with outcome (local failure). METHODS: Of 270 NSCLC patients treated with 12Gyx4, 20 were found to have local recurrence prior to the 2-year time point. These patients were originally planned with 1-D pencil beam (1-D PB) algorithm. 4D imaging was performed to manage tumor motion...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047895/tu-h-202-01-introduction-to-ct-ventilation-imaging-principles-validation-and-clinical-translation
#14
T Yamamoto
: CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047766/su-c-202-04-adapting-biologically-optimized-dose-escalation-based-on-mid-treatment-pet-ct-for-non-small-cell-lung-cancer
#15
P Zhang, L Kuo, E Yorke, Y Hu, N Lockney, G Mageras, J Deasy, A Rimner
PURPOSE: To develop a biological modeling strategy which incorporates the response observed on the mid-treatment PET/CT into a dose escalation design for adaptive radiotherapy of non-small-cell lung cancer. METHOD: FDG-PET/CT was acquired midway through standard fractionated treatment and registered to pre-treatment planning PET/CT to evaluate radiation response of lung cancer. Each mid-treatment PET voxel was assigned the median SUV inside a concentric 1cm-diameter sphere to account for registration and imaging uncertainties...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047623/su-f-r-13-decoding-18f-fdg-uptake-heterogeneity-for-primary-and-lymphoma-tumors-by-using-texture-analysis-in-pet-images
#16
C Ma, Y Yin
PURPOSE: To explore 18F-FDG uptake heterogeneity of primary tumor and lymphoma tumor by texture features of PET image and quantify the heterogeneity difference between primary tumor and lymphoma tumor. METHODS: 18 patients with primary tumor and lymphoma tumor in lung cancer were enrolled. All patients underwent whole-body 18F-FDG PET/CT scans before treatment. Texture features, based on Gray-level Co-occurrence Matrix, second and high order matrices are extracted from code using MATLAB software to quantify 18F-FDG uptake heterogeneity...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047618/su-d-207b-03-a-pet-ct-radiomics-comparison-to-predict-distant-metastasis-in-lung-adenocarcinoma
#17
T Coroller, S Yip, J Kim, S Lee, R Mak, H Aerts
PURPOSE: Early prediction of distant metastasis may provide crucial information for adaptive therapy, subsequently improving patient survival. Radiomic features that extracted from PET and CT images have been used for assessing tumor phenotype and predicting clinical outcomes. This study investigates the values of radiomic features in predicting distant metastasis (DM) in non-small cell lung cancer (NSCLC). METHODS: A total of 108 patients with stage II-III lung adenocarcinoma were included in this retrospective study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047403/su-f-j-224-impact-of-4d-pet-ct-on-percist-classification-of-lung-and-liver-metastases-in-nslc-and-colorectal-cancer
#18
J Meier, B Lopez, O Mawlawi
PURPOSE: To quantify the impact of 4D PET/CT on PERCIST metrics in lung and liver tumors in NSCLC and colorectal cancer patients. METHODS: 32 patients presenting lung or liver tumors of 1-3 cm size affected by respiratory motion were scanned on a GE Discovery 690 PET/CT. The bed position with lesion(s) affected by motion was acquired in a 12 minute PET LIST mode and unlisted into 8 bins with respiratory gating. Three different CT maps were used for attenuation correction: a clinical helical CT (CT_clin), an average CT (CT_ave), and an 8-phase 4D CINE CT (CT_cine)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047401/tu-ab-202-07-a-novel-method-for-registration-of-mid-treatment-pet-ct-images-under-conditions-of-tumor-regression-for-patients-with-locally-advanced-lung-cancers
#19
Hoda Sharifi, Hong Zhang, Jian-Yyue Jin, Feng-Ming Kong, Indrin J Chetty, Hualiang Zhong
PURPOSE: In PET-guided adaptive radiotherapy (RT), changes in the metabolic activity at individual voxels cannot be derived until the duringtreatment CT images are appropriately registered to pre-treatment CT images. However, deformable image registration (DIR) usually does not preserve tumor volume. This may induce errors when comparing to the target. The aim of this study was to develop a DIR-integrated mechanical modeling technique to track radiation-induced metabolic changes on PET images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047251/tu-h-campus-jep2-02-interobserver-variability-of-ct-pet-ct-and-mri-based-primary-tumor-delineation-for-lung-cancer
#20
K Karki, G Hugo, S Saraiya, N Jan, J Schuster, M Schutzer, L Fahrner, R Groves, J Ford, E Weiss
PURPOSE: Target delineation in lung cancer radiotherapy has, in general, large variability. MRI has so far not been investigated in detail for lung cancer delineation variability. The purpose of this study is to investigate delineation variability for lung tumors using MRI and compare it to CT alone and PET-CT based delineations. METHODS: Seven physicians delineated the primary tumor volumes of nine patients for the following scenarios: (1) CT only; (2) post-contrast T1-weighted MRI registered with diffusion-weighted MRI; and (3) PET-CT fusion images...
June 2016: Medical Physics
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