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PET-CT lung cancer

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https://www.readbyqxmd.com/read/28632689/18f-fdg-uptake-in-ischemic-colitis-during-follow-up-of-a-patient-with-lung-cancer
#1
Sofia C Vaz, Carla Oliveira, Joana C Castanheira, Ângelo F Silva, Durval C Costa
A 61-year-old man with previous history of lung adenocarcinoma underwent 2 F-FDG PET/CT investigations. The first for assessment of enlarged mediastinal lymph nodes revealed an area of increased FDG uptake in the sigmoid colon (located at the right pelvis). Colonoscopy showed a segmental area of ischemic sigmoid colitis, confirmed on histology postbiopsy. The asymptomatic man had no risk factors, and no specific treatment was administered, apart from supportive measures. One year later, there was no significantly abnormal uptake on PET/CT...
June 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28625649/investigation-of-patterns-of-nodal-metastases-in-braf-mutant-lung-cancer
#2
S H McEvoy, D F Halpenny, A Viteri-Jusué, S A Hayes, A J Plodkowski, G J Riely, M S Ginsberg
Axillary lymph nodes (axLN) are a rare site of nodal metastases in patients with lung cancer. BRAF mutated lung cancer is a genetically distinct subtype that occurs in 2-5% of non-small cell lung carcinomas (NSCLC). A recent study identified a highly unusual pattern of metastatic spread to axLN in patients with BRAF mutated colorectal cancer (CRC). The purpose of the study is to assess the incidence of axLN metastases in BRAF mutated NSCLC. Baseline computed tomography (CT) imaging at diagnosis and all follow up CTs of patients with BRAF mutated NSCLC treated at our institution were retrospectively reviewed by two radiologists for evidence of axLN metastases...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28624803/prognostic-significance-of-pd-l1-expression-and-18f-fdg-pet-ct-in-surgical-pulmonary-squamous-cell-carcinoma
#3
Minghui Zhang, Dalong Wang, Qi Sun, Haihong Pu, Yan Wang, Shu Zhao, Yan Wang, Qiangyuan Zhang
Programmed cell death-ligand 1 (PD-L1) expression is commonly observed in non-small cell lung cancer (NSCLC). The prognostic value of PD-L1 expression and the maximum standardized uptake value (SUVmax) on 18F-Fluorodeoxyglucose positron emission tomography (18FDG-PET) in surgical pulmonary squamous cell carcinoma(SCC)remains unclear. Furthermore, the correlation between the SUVmax and PD-L1 expression has not been assessed. Thus, the purpose of this study was to investigate the correlation between PD-L1 expression and the SUVmax on 18FDG-PET and to examine the prognostic significance of PD-L1 expression and the SUVmax in surgical pulmonary SCC...
May 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28608503/acute-radiation-oesophagitis-associated-with-2-deoxy-2-18f-fluoro-d-glucose-uptake-on-positron-emission-tomography-ct-during-chemo-radiation-therapy-in-patients-with-non-small-cell-lung-cancer
#4
Sarah Everitt, Jason Callahan, Eman Obeid, Rodney J Hicks, Michael Mac Manus, David Ball
INTRODUCTION: Acute radiation oesophagitis (ARO) is frequently experienced by patients receiving concurrent chemo-radiation therapy (cCRT) for non-small-cell lung cancer (NSCLC). We investigated ARO symptoms (CTCAE v3.0), radiation dose and oesophageal FDG PET/CT uptake. METHOD: Candidates received cCRT (60 Gy, 2 Gy/fx) and sequential FDG PET/CT (baseline FDG0 , FDGwk2 and FDGwk4 ). Mean and maximum standardized uptake value (SUVmean and SUVmax) and radiation dose (Omean and Omax ) were calculated within the whole oesophagus and seven sub-regions (5-60 Gy)...
June 13, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28603648/color-doppler-sonography-patterns-in-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-of-mediastinal-lymph-nodes
#5
Mario Nosotti, Alessandro Palleschi, Davide Tosi, Paolo Mendogni, Ilaria Righi, Rosaria Carrinola, Lorenzo Rosso
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is commonly used for the pathological diagnosis in patients with mediastinal lymphadenopathy. Even though the accuracy of EBUS-TBNA is considered high, several authors have tried to outline characteristic ultrasound criteria for malignant mediastinal lymph-node identification to maximize this accuracy. Recently, a color-Doppler patterns classification has been proposed by Nakajima to target suspected mediastinal lymph-nodes...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28603646/ten-year-experience-with-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-single-center-results-in-mediastinal-diagnostic-and-staging
#6
Lorenzo Rosso, Stefano Ferrero, Paolo Mendogni, Eleonora Bonaparte, Rosaria Carrinola, Alessandro Palleschi, Ilaria Righi, Matteo Montoli, Francesco Damarco, Davide Tosi
BACKGROUND: Endobronchial ultrasonography with transbronchial needle aspiration (EBUS-TBNA) is recognized as an accurate and minimal invasive procedure for diagnosis and staging of lung cancer and lymph nodal malignancies. EBUS is recommended as the first choice procedure for mediastinal staging in lung cancer in international guidelines. METHODS: A retrospective evaluation was performed on single center experience with EBUS-TBNA in our thoracic surgery department in a 10-year time frame...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28590774/fluorine-18-fluorodeoxyglucose-positron-emission-tomography-in-the-management-of-solitary-pulmonary-nodule-a-review
#7
Duilio Divisi, Mirko Barone, Gino Zaccagna, Roberto Crisci
Solitary pulmonary nodules are common radiologic findings and their detection has increased due to the introduction and improvement of diagnostics. Since a nodule can be an expression of early lung cancers, a proper classification and management are required because its treatment might lead to decreased morbidity and mortality. In this regard, prominent guidelines are available although they are characterized sometimes by discordant and misleading evidences. Furthermore, the same results of studies in the literature appear conflicting...
June 7, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28590297/high-prevalence-of-pneumothorax-on-pet-ct-studies-performed-in-lung-cancer-patients-following-post-transthoracic-needle-biopsy-mandates-careful-scrutiny
#8
Joseph Sommerfeldt, Timothy L Miao, Lionel Sydney Zuckier, Ashish Gupta
In our practice, FDG PET-CT studies are frequently performed within days of transthoracic needle biopsy, often revealing presence of pneumothorax (PTX), a "critical finding" that should be reported expeditiously. In our experience, prevalence of PTX at PET-CT performed 1 day following biopsy is greater than 40%. Of these, approximately a third are not visible on the postprocedure chest radiography, as in a case we describe. A high level of vigilance is therefore recommended to identify PTX in patients who have undergone recent transthoracic needle biopsy, even when no PTX is present immediately following the biopsy procedure...
June 5, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28588317/a-pilot-study-of-18-f-alfatide-pet-ct-imaging-for-detecting-lymph-node-metastases-in-patients-with-non-small-cell-lung-cancer
#9
Yue Zhou, Song Gao, Yong Huang, Jinsong Zheng, Yinjun Dong, Baijiang Zhang, Shuqiang Zhao, Hong Lu, Zhibo Liu, Jinming Yu, Shuanghu Yuan
Angiogenesis plays a key role in tumor development and αvβ3 integrin are overexpressed on the endothelial cell surface of newly forming vessels. (18)F-Alfatide has favorable properties for αvβ3 integrin targeting and showed potential for imaging angiogenesis with Positron Emission Tomography (PET)/computed tomography (CT). In this study, 13 patients with non-small cell lung cancer (NSCLC) who underwent (18)F-Alfatide PET/CT before surgery were enrolled. The uptake of all dissected lymph nodes (LNs) of (18)F-Alfatide were assessed visually and analyzed with a maximum and mean standard uptake value (SUVmax, SUVmean) and SUV ratios...
June 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28587000/exploring-spatial-overlap-of-high-uptake-regions-derived-from-dual-tracer-pet-ct-imaging-using-18f-fdg-and-18f-flt-in-non-small-cell-lung-cancer-patients-a-prospective-pilot-study
#10
J Liu, C Li, M Hu, J Lu, X Shi, L Xing, X Sun, Z Fu, J Yu, X Meng
No abstract text is available yet for this article.
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28586994/a-review-of-non-small-cell-lung-cancer-post-treatment-follow-up-imaging-procedures-with-pet-ct-scans-versus-ct-scans-and-the-effect-on-patient-survival
#11
J R Mansueti, S Maillie
No abstract text is available yet for this article.
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28586982/comparison-of-tumor-volumes-as-determined-by-pathologic-examination-and-flt-pet-ct-images-of-non-small-cell-lung-cancer-a-pilot-study
#12
Z Gao, X Meng, X Chen, X Sun, J Yu
No abstract text is available yet for this article.
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28583635/influence-of-pet-reconstruction-technique-and-matrix-size-on-qualitative-and-quantitative-assessment-of-lung-lesions-on-18f-fdg-pet-a-prospective-study-in-37-cancer-patients
#13
Georg Riegler, Georgios Karanikas, Ivo Rausch, Albert Hirtl, Karem El-Rabadi, Wolfgang Marik, Christopher Pivec, Michael Weber, Helmut Prosch, Marius Mayerhoefer
PURPOSE: To evaluate the influence of point spread function (PSF)-based reconstruction and matrix size for PET on (1) lung lesion detection and (2) standardized uptake values (SUV). METHODS: This prospective study included oncological patients who underwent [18F]-FDG-PET/CT for staging. PET data were reconstructed with a 2D ordered subset expectation maximization (OSEM) algorithm, and a 2D PSF-based algorithm (TrueX), separately with two matrix sizes (168×168 and 336×336)...
May 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28583587/management-of-multifocal-lung-cancer-results-of-a-survey
#14
Konstantinos Leventakos, Tobias Peikert, David Midthun, Julian R Molina, Shanda Blackmon, Francis C Nichols, Yolanda Garces, Christopher L Hallemeier, Stephen J Murphy, George Vasmatzis, Sarah L Kratz, William P Holland, Charles F Thomas, John J Mullon, K Robert Shen, Stephen D Cassivi, Randolph S Marks, Marie Christine Aubry, Alex A Adjei, Ping Yang, Mark S Allen, Eric S Edell, Dennis Wigle, Aaron S Mansfield
INTRODUCTION: Multifocal lung cancer (MFLC) is an increasingly common clinical scenario but there is lack of high-level evidence for its optimal treatment. Thus, we surveyed members of the interdisciplinary International Association for the Study of Lung Cancer (IASLC) on their therapeutic approaches and analyzed the resultant practice patterns. METHODS: We described the clinical scenario of an otherwise healthy 60 years old man with bilateral pulmonary nodules and asked the 6373 IASLC members whether they would recommend surgery, and if so, the extent of surgery...
June 2, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28577947/indications-for-invasive-mediastinal-staging-in-patients-with-early-non-small-cell-lung-cancer-staged-with-pet-ct
#15
Sarah J Gao, Anthony W Kim, Jonathan T Puchalski, Kyle Bramley, Frank C Detterbeck, Daniel J Boffa, Roy H Decker
PURPOSE/OBJECTIVE(S): Appropriate use of invasive mediastinal staging in patients with clinically node-negative NSCLC staged by PET-CT is critical in selecting patients for curative-intent therapy such as surgery or SBRT, but little data exists to guide this decision-making. We examined a large population of patients with clinical stage I NSCLC referred for mediastinoscopy or EBUS to find risk factors for occult N2 lymph nodes and determine which patients benefit from invasive staging...
July 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28572488/detection-of-synchronous-primary-malignancies-with-68-ga-psma-pet-ct-in-patients-with-prostate-cancer-frequency-in-764-patients
#16
Medhat M Osman, Amir Iravani, Michael S Hofman, Rodney J Hicks
We evaluated the incidence of synchronous primary malignancies in patients being evaluated by (68)Ga-PSMA PET/CT for prostate cancer (PC). Methods: Reports for 764 PC patients were reviewed. Incidental lesions atypical for PC metastases and suggestive of a synchronous primary malignancy were identified. Follow-up was obtained to confirm etiology. Results: Lesions atypical for PC metastases were found in 49 of 764 (6.4%) patients with a confirmed synchronous primary in 5 (0.7%) patients (2 lung, 1 lymphoma, thyroid, and base of tongue)...
June 1, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28571704/percutaneous-radiofrequency-ablation-of-lung-metastases-from-colorectal-carcinoma-under-c-arm-cone-beam-ct-guidance
#17
G Amouyal, S Pernot, C Déan, B Cholley, F Scotté, M Sapoval, O Pellerin
PURPOSE: The aim of this study was to assess the feasibility, safety and efficacy of percutaneous radiofrequency ablation of lung metastases from colorectal carcinoma using C-arm cone beam computed tomography (CBCT) guidance. MATERIAL AND METHODS: This single-center prospective observational study was performed from August 2013 to August 2016, and included consecutive patients referred for radiofrequency ablation of lung metastases from colorectal cancer. Radiofrequency ablation procedures were performed under C-arm CBCT guidance...
May 29, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28570742/effect-of-midtreatment-pet-ct-adapted-radiation-therapy-with-concurrent-chemotherapy-in-patients-with-locally-advanced-non-small-cell-lung-cancer-a-phase-2-clinical-trial
#18
Feng-Ming Kong, Randall K Ten Haken, Matthew Schipper, Kirk A Frey, James Hayman, Milton Gross, Nithya Ramnath, Khaled A Hassan, Martha Matuszak, Timothy Ritter, Nan Bi, Weili Wang, Mark Orringer, Kemp B Cease, Theodore S Lawrence, Gregory P Kalemkerian
Importance: Our previous studies demonstrated that tumors significantly decrease in size and metabolic activity after delivery of 45 Gy of fractionated radiatiotherapy (RT), and that metabolic shrinkage is greater than anatomic shrinkage. This study aimed to determine whether 18F-fludeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) acquired during the course of treatment provides an opportunity to deliver higher-dose radiation to the more aggressive areas of the tumor to improve local tumor control without increasing RT-induced lung toxicity (RILT), and possibly improve survival...
June 1, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28566260/-18-f-fdg-pet-ct-in-lung-cancer-the-added-value-of-quantification
#19
P Lapa, M Marques, J Isidoro, F Barata, G Costa, J P de Lima
OBJECTIVE: To test a software application for the quantification of metabolic heterogeneity and to evaluate its superiority in relation to visual interpretation. To investigate if a quantitative analysis adds information to the interpretation of (18)F-FDG-PET/CT. MATERIAL AND METHODS: The study analyzed 215 patients with a (18)F-FDG-PET/CT done for the initial staging of lung cancer between March 2011 and December 2015. The study included 57 (26.5%) women and 158 (73...
May 26, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28559938/ratio-of-mediastinal-lymph-node-suv-to-primary-tumor-suv-in-18-f-fdg-pet-ct-for-nodal-staging-in-non-small-cell-lung-cancer
#20
Jaehyuk Cho, Jae Gol Choe, Kisoo Pahk, Sunju Choi, Hye Ryeong Kwon, Jae Seon Eo, Hyo Jung Seo, Chulhan Kim, Sungeun Kim
PURPOSE: Following determination of the maximum standardized uptake values (SUVmax) of the mediastinal lymph nodes (SUV-LN) and of the primary tumor (SUV-T) on (18)F-FDG PET/CT in patients with non-small-cell lung cancer (NSCLC), the aim of the study was to determine the value of the SUV-LN/SUV-T ratio in lymph node staging in comparison with that of SUV-LN. METHODS: We retrospectively reviewed a total of 289 mediastinal lymph node stations from 98 patients with NSCLC who were examined preoperatively for staging and subsequently underwent pathologic studies of the mediastinal lymph nodes...
June 2017: Nuclear Medicine and Molecular Imaging
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