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Askin Erdogan, Satish S C Rao
Small intestinal fungal overgrowth (SIFO) is characterized by the presence of excessive number of fungal organisms in the small intestine associated with gastrointestinal (GI) symptoms. Candidiasis is known to cause GI symptoms particularly in immunocompromised patients or those receiving steroids or antibiotics. However, only recently, there is emerging literature that an overgrowth of fungus in the small intestine of non-immunocompromised subjects may cause unexplained GI symptoms. Two recent studies showed that 26 % (24/94) and 25...
April 2015: Current Gastroenterology Reports
C Jacobs, E Coss Adame, A Attaluri, J Valestin, S S C Rao
BACKGROUND: Whether intestinal dysmotility and the use of a proton pump inhibitor (PPI) either independently or together contributes to small intestinal bacterial overgrowth (SIBO), and/or small intestinal fungal overgrowth (SIFO) is not known. AIM: To investigate the role of dysmotility and PPI use in patients with persistent gastrointestinal complaints. METHODS: Patients with unexplained gastrointestinal symptoms and negative endoscopy/radiology tests completed a validated symptom questionnaire and underwent 24-h ambulatory antro-duodeno-jejunal manometry (ADJM)...
June 2013: Alimentary Pharmacology & Therapeutics
C Baílez Fidalgo, J C Pastor Jimeno, M A Saornil Alvarez, M C Méndez Díaz, F Martín Aparicio, E Rodríguez De La Rúa Franch, R M Sanabria Ruiz-Colmenares, M A De La Fuente Salinero, A Mayo Iscar
PURPOSE: To evaluate the usefulness of silicone-fluorsilicone copolymer oil (SiFO) as an intraoperative tool and a vitreous substitute in vitreoretinal surgery. METHODS: Handling properties of SiFO were tested and compared with those of perfluorooctane (PFO). The transparency of both substances was measured by spectrophotometry and subjectively assessed. Their tendency to dispersion was observed during injection in balanced saline solution (BSS) and after mechanized and manual shaking...
May 2004: Archivos de la Sociedad Española de Oftalmología
D Scala, A Bracco, S Cozzolino, A Cristinziano, C De Marino, A Di Martino, E Gonzalez, A Mancini, F Romagnuolo, L Zeuli
OBJECTIVE: Pharmacist-operated Drug Information Centres (DICs) in Italy were surveyed to gather current information concerning the status, availability and scope of their services. METHODS: 40 DICs were identified and a questionnaire was mailed to them. Topics covered in the questionnaire included staffing, resources, activities and services. The results were compared with previous survey results to identify trends. RESULTS: Information from 36 DICs was analysed (response rate = 90%)...
December 2001: Pharmacy World & Science: PWS
C Dahlöf, M Linde
A randomly selected sample of 1668 individuals (782 women and 886 men) aged 18-74 years was interviewed by telephone using a standardized questionnaire including the International Headache Society (IHS) criteria for migraine. The survey was performed by SIFO, the national public opinion poll agency. The results obtained demonstrate that 21% of the Swedish population had suffered from severe headaches during the past year. A majority of these headache sufferers (61%) fulfilled the IHS-criteria for migraine. The 1-year prevalence of migraine in Sweden was found to be 13...
July 2001: Cephalalgia: An International Journal of Headache
M Doi, M Ning, H Ida, Y Uji, M F Refojo
BACKGROUND: Fluorosilicone oil (FSiO, 1,000-10,000 centistokes), which has a higher density (1.29 g/cm3) than vitreous gel, is useful as an operative tool and a tamponade for the inferior retina during difficult retinal detachment surgery. The occurrence of histopathologic retinal changes after injection of FSiO into the vitreous cavity is controversial. METHODS: Retinas obtained from 18 rabbits were evaluated histopathologically within 8 weeks of injection into the vitreous cavity of purified FSiO or balanced salt solution as control in phakic eyes...
2000: Retina
A Messori, S Trippoli, P Becagli, G Zaccara
OBJECTIVE: In patients with amyotrophic lateral sclerosis, long term treatment with riluzole has been reported to improve survival or tracheostomy-free survival in comparison with placebo. We conducted a pharmacoeconomic analysis for estimating the cost per life-year gained using this drug. DESIGN: This study was an incremental cost-effectiveness lifetime analysis. SETTING: The clinical material was derived from 2 placebo-controlled randomised controlled trials comparing riluzole versus usual care without riluzole, which were identified through a literature search based on the IOWA and the Medline systems...
August 1999: PharmacoEconomics
P O Lundberg
In a survey commissioned by the National Institute of Public Health, and carried out by specially trained staff at SIFO Research and Consulting, a representative population sample (n = 2,810, or 59 per cent of the actual sample) were interviewed regarding sexual mores. The items included 800 variables reflecting social background, lifestyle, and health, as well as knowledge, attitudes and sexual behaviour. The results showed, for instance, that Swedes have more sexual partners than 30 years ago, that anal sex is a currently fashionable trend, that oral sex is common, that relatively few are coerced to participate in sexual practices, and that the abortion rate is disturbingly high...
April 21, 1999: Läkartidningen
A Messori, P Becagli, V Berto, S Trippoli, M Font, F Tosolini, F Venturini, N Martini
OBJECTIVE: This study was undertaken to evaluate the cost and the effectiveness of zidovudine monotherapy in patients with advanced HIV infection and to derive preliminary data on the cost-effectiveness of the triple treatment with saquinavir plus zalcitabine plus zidovudine compared with zidovudine alone. DESIGN: We used a combined method of survival analysis utilizing both the quality-adjusted time without symptoms or toxicity (Q-TWIST) method and the Gompertz approach...
December 1997: Annals of Pharmacotherapy
A A Veloso, E F Kadrmas, J M Larrosa, M A Sandberg, F I Tolentino, M F Refojo
The purpose of this study was to evaluate the effect of 13-cis-Retinoic Acid (RA) in Silicone-Fluorosilicone Copolymer Oil (SiFO) in a rabbit model of proliferative vitreoretinopathy (PVR). Rabbits underwent gas-compression vitrectomy. During gas-SiFO exchange, group 1 was injected with 1 ml (10 microg ml-1) 13-cis-RA in SiFO, group 2 with 1.5 ml (9 microg 1.5 ml-1) all-trans-RA in SiFO, group 3 with 1 ml SiFO alone, and group 4 with balanced salt solution (BSS). Groups 1-4 were also injected with 0.1 ml suspension of fibroblasts (75,000 0...
September 1997: Experimental Eye Research
M Nakagawa, M F Refojo, J F Marin, M Doi, F I Tolentino
PURPOSE: The authors evaluated the effect of retinoic acid (RA) in silicone oil (SiO) and in silicone-fluorosilicone (SiFO) copolymer oil in a new rabbit model of proliferative vitreoretinopathy (PVR). METHODS: To create the PVR model, three groups of rabbits were administered vitreous injections of approximately 100,000 homologous fibroblasts, 75,000 platelet-rich plasma (PRP), and fibroblasts + PRP, respectively. These rabbits were followed up ophthalmoscopically and histopathologically for as long as 2 months...
November 1995: Investigative Ophthalmology & Visual Science
L C Mullins, H L Sheppard, L Andersson
This study examined: 1) the loneliness experienced by a representative sample of persons from Sweden in 1986, and 2) the relative impact of age, gender, household size, subjective health assessments, and two indicators of income adequacy on loneliness. The results are based on the responses to a telephone survey, conducted by SIFO, of a weighted subsample of 212 persons aged 65+. The overall sample consisted of 1005 person 16 years of age and older. In general, only a minority (27%) of the Swedish elderly indicated loneliness was at least a somewhat serious problem...
April 1988: Comprehensive Gerontology. Section B, Behavioural, Social, and Applied Sciences
W Roediger, G Schapel, M Lawson, B Radcliffe, S Nance
5-Aminosalicylic acid (5-ASA) suppressed nitrite-stimulated oxidation of the fatty acid n-butyrate in a dose-dependent manner in isolated human and rat colonic epithelial cells. 4-ASA had one-sixth of the capacity of 5-ASA and sulphapyridine (SP) little of the capacity of 5-ASA to suppress fatty acid oxidation in human colonic epithelial cells. Sulphasalazine (SASP), azodisalicylic acid (ADS), acetyl-5-ASA and acetyl salicylic acid (ASA) did not suppress fatty acid oxidation in rat colonocytes. The suppression index of fatty acid oxidation (SIFO) of respective salicylic acids correlated with the reported clinical effectiveness of each drug against ulcerative colitis (UC)...
January 15, 1986: Biochemical Pharmacology
W E Roediger, E J Deakin, G Walker, S H Nance
The therapeutic efficacy of salicylate drugs for ulcerative colitis in vivo is related to the capacity of each drug to suppress fatty acid oxidation in colonocytes in vitro. The suppression index of fatty acid oxidation (SIFO) was assessed with 17 salicylate drugs of either known or unknown therapeutic efficacy. The high SIFO value of 5-aminosalicylic acid (5-ASA) was reduced to zero when the amino group was replaced with a methyl, nitro, hydroxyl or bromine group. The SIFO of 3-ASA was dose-related and 2- to 3-fold greater than the SIFO of 5-ASA...
1989: Pharmacology
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