keyword
MENU ▼
Read by QxMD icon Read
search

Brdu

keyword
https://www.readbyqxmd.com/read/28818485/role-of-stromal-derived-factor-1a-sdf-1a-for-spermatogenesis-of-busulfan-injured-rats
#1
Neda Khanlarkhani, Keywan Mortezaee, Fardin Amidi, Ebrahim Kharazinejad, Cordian Beyer, Maryam Baazm, Parichehr Pasbakhsh, Azar Pazhohan, Aligholi Sobhani, Adib Zendedel
SDF-1a is a member of CXC chemokine family that plays a crucial role in stem cell migration, cell apoptosis and development. The role of intra-scrotal administration of SDF-1a in spermatogenesis of busulfan-treated rats was investigated in this study. Two injections of busulfan (15mg/kg) with a 14days interval between were given intraperitoneally to male Wistar rats. Rats were then treated for seven days with 500ng/mL SDF-1a. Real-time PCR and immunohistochemistry were performed for evaluation of various cell markers for proliferation and spermatogenesis, and sperm parameters were assessed...
August 14, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28814279/musashi-1-is-the-candidate-of-the-regulator-of-hair-cell-progenitors-during-inner-ear-regeneration
#2
Takahiro Wakasaki, Hiroaki Niiro, Siamak Jabbarzadeh-Tabrizi, Mitsuru Ohashi, Takashi Kimitsuki, Takashi Nakagawa, Shizuo Komune, Koichi Akashi
BACKGROUND: Hair cell loss in the cochlea is caused by ototoxic drugs, aging, and environmental stresses and could potentially lead to devastating pathophysiological effects. In adult mammals, hair cell loss is irreversible and may result in hearing and balance deficits. In contrast, nonmammalian vertebrates, including birds, can regenerate hair cells through differentiation of supporting cells and restore inner ear function, suggesting that hair cell progenitors are present in the population of supporting cells...
August 16, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28811537/prognostic-significance-and-function-of-mammalian-target-of-rapamycin-in-tongue-squamous-cell-carcinoma
#3
Shau-Hsuan Li, Chih-Yen Chien, Wan-Ting Huang, Sheng-Dean Luo, Yan-Ye Su, Wan-Yu Tien, Ya-Chun Lan, Chang-Han Chen
Despite improvement in preoperative imaging, surgical technique, and adjuvant therapy, the prognosis of patients with tongue squamous cell carcinoma (SCC) is still unsatisfactory. The mammalian target of rapamycin (mTOR) play a key role in the regulation of tumor cell proliferation and survival. However, the significance of mTOR on the prognosis of tongue SCC remains largely undefined. In the present study, immunohistochemistry was performed to evaluate the expression of phosphorylated mTOR (p-mTOR) in 160 surgically resected tongue SCC, and correlated with survival...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811227/the-chemotherapeutic-agent-paclitaxel-selectively-impairs-reversal-learning-while-sparing-prior-learning-new-learning-and-episodic-memory
#4
Danielle Panoz-Brown, Lawrence M Carey, Alexandra E Smith, Meredith Gentry, Christina M Sluka, Hannah E Corbin, Jie-En Wu, Andrea G Hohmann, Jonathon D Crystal
Chemotherapy is widely used to treat patients with systemic cancer. The efficacy of cancer therapies is frequently undermined by adverse side effects that have a negative impact on the quality of life of cancer survivors. Cancer patients who receive chemotherapy often experience chemotherapy-induced cognitive impairment across a variety of domains including memory, learning, and attention. In the current study, the impact of paclitaxel, a taxane derived chemotherapeutic agent, on episodic memory, prior learning, new learning, and reversal learning were evaluated in rats...
August 12, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28809399/evidence-for-newly-generated-interneurons-in-the-basolateral-amygdala-of-adult-mice
#5
D J Jhaveri, A Tedoldi, S Hunt, R Sullivan, N R Watts, J M Power, P F Bartlett, P Sah
New neurons are continually generated from the resident populations of precursor cells in selective niches of the adult mammalian brain such as the hippocampal dentate gyrus and the olfactory bulb. However, whether such cells are present in the adult amygdala, and their neurogenic capacity, is not known. Using the neurosphere assay, we demonstrate that a small number of precursor cells, the majority of which express Achaete-scute complex homolog 1 (Ascl1), are present in the basolateral amygdala (BLA) of the adult mouse...
August 15, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28808404/in-vitro-antioxidant-and-antiproliferative-activities-of-various-solvent-fractions-from-clerodendrum-viscosum-leaves
#6
Anil Khushalrao Shendge, Tapasree Basu, Dipankar Chaudhuri, Sourav Panja, Nripendranath Mandal
BACKGROUND: Free radicals such as reactive oxygen and nitrogen species, generated in the body, play an important role in the fulfillment of various physiological functions but their imbalance in the body lead to cellular injury and various clinical disorders such as cancer, neurodegenaration, and inflammation. OBJECTIVE: The objective of this study is to fight this problem, natural antioxidant from plants can be considered as possible protective agents against various diseases such as cancer which might also modify the redox microenvironment to reduce the genetic instability...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28808378/rutamarin-an-active-constituent-from-ruta-angustifolia-pers-induced-apoptotic-cell-death-in-the-ht29-colon-adenocarcinoma-cell-line
#7
Shafinah Ahmad Suhaimi, Sok Lai Hong, Sri Nurestri Abdul Malek
BACKGROUND: Ruta angustifolia Pers. is a perennial herb that is cultivated worldwide, including Southeast Asia, for the treatment of various diseases as traditional medicine. OBJECTIVE: The purpose of the study was to identify an active principle of R. angustifolia and to investigate its effect on the HT29 cell death. MATERIALS AND METHODS: The methanol and fractionated extracts (hexane, chloroform, ethyl acetate, and water) of R. angustifolia Pers...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28807787/trigeminal-nerve-stimulation-induces-fos-immunoreactivity-in-selected-brain-regions-increases-hippocampal-cell-proliferation-and-reduces-seizure-severity-in-rats
#8
Beniamina Mercante, Paolo Enrico, Gabriele Floris, Marina Quartu, Marianna Boi, Maria Pina Serra, Paolo Follesa, Franca Deriu
Sites and mechanisms by which trigeminal nerve stimulation (TNS) exerts beneficial effects on symptoms of drug-resistant epilepsy and depression are still unknown. Effects of short-term TNS on brain regions involved in the physiopathology of these disorders were investigated in this study. Forty male rats were assigned to 3 groups: TNS (undergoing electrical stimulation of the left infraorbitary nerve via surgically implanted cuff electrodes); Sham (undergoing surgical procedure but without a stimulation); Naïve rats...
August 11, 2017: Neuroscience
https://www.readbyqxmd.com/read/28805349/crispr-assisted-receptor-deletion-reveals-distinct-roles-for-erbb2-and-erbb3-in-skin-keratinocytes
#9
Maik Dahlhoff, Nadege Gaborit, Sebastian Bultmann, Heinrich Leonhardt, Yosef Yarden, Marlon R Schneider
While the epidermal growth factor receptor (EGFR) is an established regulator of skin development and homeostasis, the functions of the related tyrosine kinase receptors ERBB2 and ERBB3 in this tissue have only recently been examined. Previously reported, skin-specific deletion of each of these receptors in mice resulted in similar defects in keratinocyte proliferation and migration, resulting in impaired wound healing and tumorigenesis. Because both ERBB2 and ERBB3 are targets for treating an array of cancer types, it is important to examine the consequences of receptor inhibition in human keratinocytes...
August 14, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28801284/-yiqihuoxue-prescription-promotes-nerve-regeneration-by-mir-124-mediated-regulation-of-wnt-signaling-in-rats
#10
Hui Tan, Jian Wang, Ting-Ting Yin, Ling He, Yong Deng, Feng Li, Yu-Feng Wang
OBJECTIVE: To investigate the effect of Yiqihuoxue prescription (NLXT) on nerve regeneration in MCAO-R rat models of qi deficiency and blood stasis syndrome and explore the underlying mechanisms. METHODS: The rats were randomized into 4 groups, namely the control group, model group, NLXT group and TXL group. The rats in NLXT group and TXL group were treated with gavage of NLXT and TXL solutions, respectively. The NFDS, QDSS and BSSS of the rats were evaluated. The regional cerebral blood flow (rCBF) were dynamically monitored with laser Doppler scanning, and the volume of cerebral infarction was detected with TTC-dye; the expression levels of nestin and BrdU were assayed with immunohistochemistry and mmunofluorescent staining...
August 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28790132/trb3-is-elevated-in-psoriasis-vulgaris-lesions-and-mediates-hacat-cells-proliferation-in-vitro
#11
Xiao-Jing Yu, Tie-Jun Song, Lu-Wei Zhang, Ying Su, Ke-Yu Wang, Qing Sun
Psoriasis is a chronic skin disease characterized by abnormal keratinocyte proliferation and differentiation, inflammation, and angiogenesis. Overexpression of tribbles homolog3 (TRB3), which belongs to the tribbles family of pseudokinases, has been found in several human tumors and metabolic diseases, but its role in psoriasis has not been fully clarified. The aim of this study is to investigate the expression of TRB3 in psoriasis and explore its roles in the proliferation of keratinocytes. Twenty-four patients with psoriasis vulgaris were recruited for the study...
August 7, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28783582/cytotoxic-effects-of-fritillaria-imperialis-l-extracts-on-human-liver-cancer-cells-breast-cancer-cells-and-fibroblast-like-cells
#12
Ozra Zarei, Mohammad Mehdi Yaghoobi
In this study, we evaluated the cytotoxic effects of Fritillaria imperialis L. aqueous and ethanolic extracts on human liver cancer cells (LCL-PI 11), breast adenocarcinoma cells (MCF-7) and fibroblast-like cells (HSkMC). MTT, BrdU and TUNEL assays were used to detect cytotoxicity, proliferation rate and apoptotic death. Following 48h, the IC50 values for LCL-PI11 and MCF-7 cells were 4.2 and 3.9μg/mL of aqueous extract, and 1.7 and 1.3μg/mL of ethanolic extract, respectively, which was comparable to that of 5-FU...
August 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28782255/pou3f2-participates-in-cognitive-function-and-adult-hippocampal-neurogenesis-via-mammalian-characteristic-amino-acid-repeats
#13
Koichi Hashizume, Masashi Yamanaka, Shintaroh Ueda
POU3F2/BRN-2 is a transcription factor that is mainly expressed in the central nervous system and plays an important role in brain development. The transactivation domain of POU3F2 includes multiple mammalian-characteristic tandem amino acid repeats (homopolymeric amino acid repeats). We previously generated knock-in mice (Pou3f2(Δ)(/Δ) mice) in which all three homopolymeric amino acid repeats were deleted from the Pou3f2 transactivation domain and identified phenotypic impairments in maternal behavior and pup recognition...
August 7, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28780644/immunopotentiator-thymosin-alpha-1-promotes-neurogenesis-and-cognition-in-the-developing-mouse-via-a-systemic-th1-bias
#14
Ge Wang, Fen He, Yunlong Xu, Yuwei Zhang, Xiao Wang, Chunhua Zhou, Yihong Huang, Juntao Zou
In early life, the immune system plays an essential role in brain development. In our study, the immunopotentiator thymosin alpha-1 (Ta1) was peripherally administered to neonatal mice to explore whether the peripheral immunopotentiator affects neurodevelopment and cognition, and to further investigate the relevant mechanism. Compared with the control group, the Ta1 mice displayed better cognitive abilities in early life. The numbers of 5-bromodeoxyuridine (BrdU)+, nestin+, T-box transcription factor 2 (Tbr2)+, BrdU+/doublecortin (DCX)+, BrdU+/ionized calcium-binding adaptor molecule 1 (Iba1)+, and BrdU+/neuronal nuclei (NeuN)+ cells in the hippocampus were increased in the Ta1 group, accompanied by increased interleukin-4 (IL-4), interferon-gamma, brain-derived neurotrophic factor, nerve growth factor, and insulin-like growth factor-1 as well as decreased IL-6 and tumor necrosis factor-α...
August 5, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28777210/rapamycin-prolongs-graft-survival-and-induces-cd4-ifn-%C3%AE-il-10-regulatory-type-1-cells-in-old-recipient-mice
#15
Markus Quante, Timm Heinbokel, Karoline Edtinger, Koichiro Minami, Hirofumi Uehara, Yeqi Nian, Haruhito Azuma, Reza Abdi, Abdallah Elkhal, Stefan G Tullius
BACKGROUND: Although the elderly represents a rapidly growing population among transplant recipients, age-specific aspects have not been considered sufficiently in clinical trials. Moreover, age-specific effects of immunosuppressive therapies remain poorly understood. METHODS: Here, we assessed the impact of Rapamycin on alloimmune responses in old recipients using a fully MHC-mismatched murine transplantation model. RESULTS: Old untreated recipients displayed a prolonged skin graft survival compared to their young counterparts, an observation that confirmed data of our previous experiments...
August 2, 2017: Transplantation
https://www.readbyqxmd.com/read/28775288/a-polypeptide-from-the-junction-region-sequence-of-ews-fli1-inhibits-ewing-s-sarcoma-cells-interacts-with-the-ews-fli1-and-partner-proteins
#16
Krishna Priya Thangaretnam, Gopal Gopisetty, Priya Ramanathan, Thangarajan Rajkumar
The EWS-FLI1 chimeric protein uniquely expressed in Ewing's sarcoma has an obligate role in its aetiology. In our previous report we showed that ectopic expression of the DNA sequences form the junction region (a.a 251-280) can inhibit Ewing's sarcoma cell growth. In the present report, we introduced a peptide (TAT/NLS/EWS-PEP) comprising of thirty amino acids spanning the junction in conjunction with HIV-1-trans-activating (TAT) and nuclear localization signal sequence (NLS). Peptide uptake and localization studies revealed presence of peptide in ~99% of transduced cells and in the nucleus...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28771727/salvianolic-acids-enhance-cerebral-angiogenesis-and-neurological-recovery-by-activating-jak2-stat3-signaling-pathway-after-ischemic-stroke-in-mice
#17
Yaoru Li, Xiangjian Zhang, Lili Cui, Rong Chen, Ye Zhang, Cong Zhang, Xingyuan Zhu, Tingting He, Zuyuan Shen, Lipeng Dong, Jingru Zhao, Ya Wen, Xiufen Zheng, Pan Li
Post-stroke angiogenesis facilitates neurovascular remodeling process and promotes neurological recovery. Proangiogenic effects of Salvianolic acids (Sals) have been reported in various ischemic disorders. However, the underlying mechanisms are still poorly understood. Previous studies of our laboratory have demonstrated that activating Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway is involved in the protection against cerebral ischemia/reperfusion injury. In the present study, we investigated the impacts of Sals on angiogenesis and long-term neurological recovery after ischemic stroke as well as the potential mechanisms...
August 3, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28770438/differential-effects-of-low-and-high-dose-zinc-supplementation-on-synaptic-plasticity-and-neurogenesis-in-the-hippocampus-of-control-and-high-fat-diet-fed-mice
#18
Sung Min Nam, Jong Whi Kim, Hyun Jung Kwon, Dae Young Yoo, Hyo Young Jung, Dae Won Kim, In Koo Hwang, Je Kyung Seong, Yeo Sung Yoon
In the present study, we investigated the concentration-dependent effect of zinc (Zn) supplementation on the adult hippocampus in a high-fat diet (HFD)-fed obese mouse model. Four-weeks after HFD- and control diet (CD)-feeding, mice were provided with low (15 ppm) or high (60 ppm) doses of Zn in their drinking water for additional 4 more weeks along with their respective diets. Compared to the CD-fed mice, HFD-feeding elicited the reduction of neurogenic markers such as nestin, Ki67, doublecortin (DCX), and 5-bromo-2'-deoxyuridine (BrdU) in the dentate gyrus...
August 2, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28767193/decreased-hippocampal-brain-derived-neurotrophic-factor-and-impaired-cognitive-function-by-hypoglossal-nerve-transection-in-rats
#19
Doyun Kim, Sena Chung, Seung-Hyun Lee, Se-Young Choi, Soung-Min Kim, JaeHyung Koo, Jong-Ho Lee, Jeong Won Jahng
The hypoglossal nerve controls tongue movements, and damages of it result in difficulty in mastication and food intake. Mastication has been reported to maintain hippocampus-dependent cognitive function. This study was conducted to examine the effect of tongue motor loss on the hippocampus-dependent cognitive function and its underlying mechanism. Male Sprague Dawley rats were subjected to the initial training of Morris water maze task before or after the bilateral transection of hypoglossal nerves (Hx). When the initial training was given before the surgery, the target quadrant dwelling time during the probe test performed at a week after the surgery was significantly reduced in Hx rats relative to sham-operated controls...
August 2, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28765960/microrna-616-promotes-the-growth-and-metastasis-of-non-small-cell-lung-cancer-by-targeting-sox7
#20
Danping Wang, Qifeng Cao, Meijun Qu, Zhaoqun Xiao, Minghui Zhang, Songbo Di
MicroRNAs (miRNAs) are a group of important regulators in human types of cancer including non-small cell lung cancer (NSCLC). miR-616 has been found to be a novel cancer-related miRNA. However, the expression and biological function of miR-616 in NSCLC have not been investigated. In this study, qRT-PCR was performed to evaluate the level of miR-616 in NSCLC tissues. MTT, BrdU and Transwell assay were used to investigate the proliferation and metastasis ability of NSCLC cells. Subcutaneous injection model and tail vein injection model were used to evaluate the effect of miR-616 on the in vivo growth and metastasis of NSCLC cells...
July 28, 2017: Oncology Reports
keyword
keyword
65340
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"