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Epigenetic clock

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https://www.readbyqxmd.com/read/29898451/pathophysiology-of-depression-molecular-regulation-of-melatonin-homeostasis-current-status
#1
REVIEW
Monika Dmitrzak-Weglarz, Edyta Reszka
Circadian rhythm alterations resulting in disturbed sleep and disturbed melatonin secretion are flagship features of depression. Melatonin, known as a hormone of darkness, is secreted by the pineal gland located near to the center of the brain between the two hemispheres. Melatonin has an antidepressant effect by maintaining the body's circadian rhythm, by regulating the pattern of expression of the clock genes in the suprachiasmatic nucleus (SCN) and modifying the key genes of serotoninergic neurotransmission that are linked with a depressive mood...
June 13, 2018: Neuropsychobiology
https://www.readbyqxmd.com/read/29897034/posttraumatic-psychopathology-and-the-pace-of-the-epigenetic-clock-a-longitudinal-investigation
#2
Erika J Wolf, Mark W Logue, Filomene G Morrison, Elizabeth S Wilcox, Annjanette Stone, Steven A Schichman, Regina E McGlinchey, William P Milberg, Mark W Miller
BACKGROUND: Posttraumatic stress disorder (PTSD) and stress/trauma exposure are cross-sectionally associated with advanced DNA methylation age relative to chronological age. However, longitudinal inquiry and examination of associations between advanced DNA methylation age and a broader range of psychiatric disorders is lacking. The aim of this study was to examine if PTSD, depression, generalized anxiety, and alcohol-use disorders predicted acceleration of DNA methylation age over time (i...
June 13, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29892055/brain-age-and-other-bodily-ages-implications-for-neuropsychiatry
#3
REVIEW
James H Cole, Riccardo E Marioni, Sarah E Harris, Ian J Deary
As our brains age, we tend to experience cognitive decline and are at greater risk of neurodegenerative disease and dementia. Symptoms of chronic neuropsychiatric diseases are also exacerbated during ageing. However, the ageing process does not affect people uniformly; nor, in fact, does the ageing process appear to be uniform even within an individual. Here, we outline recent neuroimaging research into brain ageing and the use of other bodily ageing biomarkers, including telomere length, the epigenetic clock, and grip strength...
June 11, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29888306/accelerated-dna-methylation-aging-and-increased-resilience-in-veterans-the-biological-cost-for-soldiering-on
#4
Divya Mehta, Dagmar Bruenig, Bruce Lawford, Wendy Harvey, Tania Carrillo-Roa, Charles P Morris, Tanja Jovanovic, Ross McD Young, Elisabeth B Binder, Joanne Voisey
Accelerated epigenetic aging, the difference between the DNA methylation-predicted age (DNAm age) and the chronological age, is associated with a myriad of diseases. This study investigates the relationship between epigenetic aging and risk and protective factors of PTSD. Genome-wide DNA methylation analysis was performed in 211 individuals including combat-exposed Australian veterans (discovery cohort, n = 96 males) and trauma-exposed civilian males from the Grady Trauma Project (replication cohort, n = 115 males)...
February 2018: Neurobiology of Stress
https://www.readbyqxmd.com/read/29807573/cell-cycle-and-apoptosis-regulator-2-at-the-interface-between-dna-damage-response-and-cell-physiology
#5
REVIEW
Martina Magni, Giacomo Buscemi, Laura Zannini
Cell cycle and apoptosis regulator 2 (CCAR2 or DBC1) is a human protein recently emerged as a novel and important player of the DNA damage response (DDR). Indeed, upon genotoxic stress, CCAR2, phosphorylated by the apical DDR kinases ATM and ATR, increases its binding to the NAD+-dependent histone deacetylase SIRT1 and inhibits SIRT1 activity. This event promotes the acetylation and activation of p53, a SIRT1 target, and the subsequent induction of p53 dependent apoptosis. In addition, CCAR2 influences DNA repair pathway choice and promotes the chromatin relaxation necessary for the repair of heterochromatic DNA lesions...
April 2018: Mutation Research
https://www.readbyqxmd.com/read/29796118/epigenetic-aging-of-human-hematopoietic-cells-is-not-accelerated-upon-transplantation-into-mice
#6
Joana Frobel, Susann Rahmig, Julia Franzen, Claudia Waskow, Wolfgang Wagner
Background: Transplantation of human hematopoietic stem cells into immunodeficient mice provides a powerful in vivo model system to gain functional insights into hematopoietic differentiation. So far, it remains unclear if epigenetic changes of normal human hematopoiesis are recapitulated upon engraftment into such "humanized mice." Mice have a much shorter life expectancy than men, and therefore, we hypothesized that the xenogeneic environment might greatly accelerate the epigenetic clock...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29789923/the-haf2-protein-shapes-histone-acetylation-levels-of-prr5-and-lux-loci-in-arabidopsis
#7
Kyounghee Lee, Pil Joon Seo
The histone acetyltransferase HAF2 facilitates H3 acetylation deposition at the PRR5 and LUX promoters to contribute to robust circadian oscillation. The circadian clock ensures synchronization of endogenous rhythmic processes with environmental cycles. Multi-layered regulation underlies precise circadian oscillation, and epigenetic regulation is emerging as a crucial scheme for robust circadian maintenance. Here, we report that HISTONE ACETYLTRANSFERASE OF THE TAFII250 FAMILY 2 (HAF2) is involved in circadian homeostasis...
May 22, 2018: Planta
https://www.readbyqxmd.com/read/29746298/perinatally-acquired-hiv-infection-accelerates-epigenetic-aging-in-south-african-adolescents
#8
Steve Horvath, Nicole Phillips, Sarah J Heany, Michael S Kobor, David Ts Lin, Landon Myer, Heather J Zar, Dan J Stein, Andrew J Levine, Jacqueline Hoare
OBJECTIVE: Recent studies demonstrate that infection with the Human Immunodeficiency Virus-1 (HIV) is associated with accelerated aging effects in adults according to a highly accurate epigenetic biomarker of aging known as epigenetic clock. However, it not yet known whether epigenetic age acceleration occurs as early as adolescence in perinatally HIV-infected (PHIV+) youth. DESIGN: Observational study of PHIV and HIV-uninfected adolescents enrolled in the Cape Town Adolescent Antiretroviral Cohort (CTAAC) Study...
May 8, 2018: AIDS
https://www.readbyqxmd.com/read/29718110/tracking-the-epigenetic-clock-across-the-human-life-course-a-meta-analysis-of-longitudinal-cohort-data
#9
Riccardo E Marioni, Matthew Suderman, Brian H Chen, Steve Horvath, Stefania Bandinelli, Tiffany Morris, Stephan Beck, Luigi Ferrucci, Nancy L Pedersen, Caroline L Relton, Ian J Deary, Sara Hägg
Background: Epigenetic clocks based on DNA methylation yield high correlations with chronological age in cross-sectional data. Due to a paucity of longitudinal data, it is not known how Δage (epigenetic age - chronological age) changes over time or if it remains constant from childhood to old age. Here, we investigate this using longitudinal DNA methylation data from five datasets, covering most of the human life course. Methods: Two measures of the epigenetic clock (Hannum and Horvath) are used to calculate Δage in the following cohorts: Avon Longitudinal Study of Parents and Children (ALSPAC) offspring (n = 986, total age-range 7-19 years, 2 waves), ALSPAC mothers (n = 982, 16-60 years, 2 waves), InCHIANTI (n = 460, 21-100 years, 2 waves), SATSA (n = 373, 48-99 years, 5 waves), Lothian Birth Cohort 1936 (n = 1,054, 70-76 years, 3 waves), and Lothian Birth Cohort 1921 (n = 476, 79-90 years, 3 waves)...
March 20, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29706161/the-epigenetic-clock-at-birth-associations-with-maternal-antenatal-depression-and-child-psychiatric-problems
#10
Anna Suarez, Jari Lahti, Darina Czamara, Marius Lahti-Pulkkinen, Anna K Knight, Polina Girchenko, Esa Hämäläinen, Eero Kajantie, Jari Lipsanen, Hannele Laivuori, Pia M Villa, Rebecca M Reynolds, Alicia K Smith, Elisabeth B Binder, Katri Räikkönen
OBJECTIVE: Maternal antenatal depression may compromise the fetal developmental milieu and contribute to individual differences in aging and disease trajectories in later life. We evaluated the association between maternal antenatal depression and a novel biomarker of aging at birth, namely epigenetic gestational age (GA) based on fetal cord blood methylation data. We also examined whether this biomarker prospectively predicts and mediates maternal effects on early childhood psychiatric problems...
May 2018: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29703143/diapause-in-a-tropical-oil-collecting-bee-molecular-basis-unveiled-by-rna-seq
#11
Priscila Karla F Santos, Natalia de Souza Araujo, Elaine Françoso, Alexandre Rizzo Zuntini, Maria Cristina Arias
BACKGROUND: Diapause is a natural phenomenon characterized by an arrest in development that ensures the survival of organisms under extreme environmental conditions. The process has been well documented in arthropods. However, its molecular basis has been mainly studied in species from temperate zones, leaving a knowledge gap of this phenomenon in tropical species. In the present study, the Neotropical and solitary bee Tetrapedia diversipes was employed as a model for investigating diapause in species from tropical zones...
April 27, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29692214/peripheral-dna-methylation-cognitive-decline-and-brain-aging-pilot-findings-from-the-whitehall-ii-imaging-study
#12
Leonidas Chouliaras, Ehsan Pishva, Rita Haapakoski, Eniko Zsoldos, Abda Mahmood, Nicola Filippini, Joe Burrage, Jonathan Mill, Mika Kivimäki, Katie Lunnon, Klaus P Ebmeier
AIM: The present study investigated the link between peripheral DNA methylation (DNAm), cognitive impairment and brain aging. METHODS: We tested the association between blood genome-wide DNAm profiles using the Illumina 450K arrays, cognitive dysfunction and brain MRI measures in selected participants of the Whitehall II imaging sub-study. RESULTS: Eight differentially methylated regions were associated with cognitive impairment. Accelerated aging based on the Hannum epigenetic clock was associated with mean diffusivity and global fractional anisotropy...
May 2018: Epigenomics
https://www.readbyqxmd.com/read/29691382/snord116-dependent-diurnal-rhythm-of-dna-methylation-in-mouse-cortex
#13
Rochelle L Coulson, Dag H Yasui, Keith W Dunaway, Benjamin I Laufer, Annie Vogel Ciernia, Yihui Zhu, Charles E Mordaunt, Theresa S Totah, Janine M LaSalle
Rhythmic oscillations of physiological processes depend on integrating the circadian clock and diurnal environment. DNA methylation is epigenetically responsive to daily rhythms, as a subset of CpG dinucleotides in brain exhibit diurnal rhythmic methylation. Here, we show a major genetic effect on rhythmic methylation in a mouse Snord116 deletion model of the imprinted disorder Prader-Willi syndrome (PWS). More than 23,000 diurnally rhythmic CpGs are identified in wild-type cortex, with nearly all lost or phase-shifted in PWS...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29643443/dna-methylation-based-biomarkers-and-the-epigenetic-clock-theory-of-ageing
#14
REVIEW
Steve Horvath, Kenneth Raj
Identifying and validating molecular targets of interventions that extend the human health span and lifespan has been difficult, as most clinical biomarkers are not sufficiently representative of the fundamental mechanisms of ageing to serve as their indicators. In a recent breakthrough, biomarkers of ageing based on DNA methylation data have enabled accurate age estimates for any tissue across the entire life course. These 'epigenetic clocks' link developmental and maintenance processes to biological ageing, giving rise to a unified theory of life course...
June 2018: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/29614968/biological-clocks-and-physical-functioning-in-monozygotic-female-twins
#15
Elina Sillanpää, Eija K Laakkonen, Elina Vaara, Taina Rantanen, Vuokko Kovanen, Sarianna Sipilä, Jaakko Kaprio, Miina Ollikainen
BACKGROUND: Biomarkers of biological aging - DNA methylation age (DNAm age) and leukocyte telomere length (LTL)- correlate strongly with chronological age across the life course. It is, however, unclear how these measures of cellular wear and tear are associated with muscle strength and functional capacity, which are known to decline with older age and are associated with mortality. We investigated if DNAm age and LTL were associated with body composition and physical functioning by examining 48 monozygotic twin sisters...
April 4, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29593783/perinatal-programming-of-circadian-clock-stress-crosstalk
#16
REVIEW
Mariana Astiz, Henrik Oster
An intact communication between circadian clocks and the stress system is important for maintaining physiological homeostasis under resting conditions and in response to external stimuli. There is accumulating evidence for a reciprocal interaction between both-from the systemic to the molecular level. Disruption of this interaction by external factors such as shiftwork, jetlag, or chronic stress increases the risk of developing metabolic, immune, or mood disorders. From experiments in rodents, we know that both systems maturate during the perinatal period...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29567492/paternal-cocaine-disrupts-offspring-circadian-clock-function-in-a-sex-dependent-manner-in-mice
#17
Alexandra M Yaw, Robert W Woodruff, Rebecca A Prosser, J David Glass
The present study is the first to explore the multigenerational effects of mammalian paternal cocaine intake on offspring (F1) circadian clock regulation. Parental cocaine use poses significant health risks to the offspring, through both maternal and paternal drug influences. With respect to the latter, recent evidence suggests that a paternal mode of cocaine inheritance involves epigenetic germ line actions that can ultimately disrupt offspring behavior. Based on our previous report in mice that free-running circadian period (tau) is chronically lengthened following withdrawal from long-term cocaine treatment, the present study was undertaken to explore potential epigenetic effects of paternal exposure to cocaine over the ∼40-day murine spermatogenic cycle on F1 circadian regulatory functions...
May 21, 2018: Neuroscience
https://www.readbyqxmd.com/read/29555673/epigenetic-age-acceleration-a-biological-doomsday-clock-for-cardiovascular-disease
#18
EDITORIAL
Michael M Mendelson
No abstract text is available yet for this article.
March 2018: Circulation. Genomic and precision medicine
https://www.readbyqxmd.com/read/29554203/molecular-aging-of-human-liver-an-epigenetic-transcriptomic-signature
#19
Maria Giulia Bacalini, Claudio Franceschi, Davide Gentilini, Francesco Ravaioli, Xiaoyuan Zhou, Daniel Remondini, Chiara Pirazzini, Cristina Giuliani, Elena Marasco, Noémie Gensous, Anna Maria Di Blasio, Ewa Ellis, Roberto Gramignoli, Gastone Castellani, Miriam Capri, Stephen Strom, Christine Nardini, Matteo Cescon, Gian Luca Grazi, Paolo Garagnani
The feasibility of liver transplantation from old healthy donors suggests that this organ is able to preserve its functionality during aging. To explore the biological basis of this phenomenon, we characterized the epigenetic profile of liver biopsies collected from 45 healthy liver donors ranging from 13 to 90 years old using the Infinium HumanMethylation450 BeadChip. The analysis indicates that a large remodeling in DNA methylation patterns occurs, with 8823 age-associated differentially methylated CpG probes...
March 15, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29529061/profiling-dna-methylation-differences-between-inbred-mouse-strains-on-the-illumina-human-infinium-methylationepic-microarray
#20
Hemant Gujar, Jane W Liang, Nicholas C Wong, Khyobeni Mozhui
The Illumina Infinium MethylationEPIC provides an efficient platform for profiling DNA methylation in humans at over 850,000 CpGs. Model organisms such as mice do not currently benefit from an equivalent array. Here we used this array to measure DNA methylation in mice. We defined probes targeting conserved regions and performed differential methylation analysis and compared between the array-based assay and affinity-based DNA sequencing of methyl-CpGs (MBD-seq) and reduced representation bisulfite sequencing...
2018: PloS One
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