keyword
MENU ▼
Read by QxMD icon Read
search

Epigenetic clock

keyword
https://www.readbyqxmd.com/read/29432558/models-of-epigenetic-age-capture-patterns-of-dna-methylation-in-glioma-associated-with-molecular-subtype-survival-and-recurrence
#1
Peter Liao, Quinn T Ostrom, Lindsay Stetson, Jill S Barnholtz-Sloan
Background: Models of epigenetic aging (epigenetic clocks) have been implicated as potentially useful markers for cancer risk and prognosis. Using two previously published methods for modeling epigenetic age, Horvath's clock and epiTOC, we investigated epigenetic aging patterns related to WHO grade and molecular subtype as well as associations of epigenetic aging with glioma survival and recurrence. Methods: Epigenetic ages were calculated using Horvath's clock and epiTOC on 516 lower grade glioma and 141 glioblastoma cases along with 136 non-tumor (normal) brain samples...
February 8, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29374233/gwas-of-epigenetic-aging-rates-in-blood-reveals-a-critical-role-for-tert
#2
Ake T Lu, Luting Xue, Elias L Salfati, Brian H Chen, Luigi Ferrucci, Daniel Levy, Roby Joehanes, Joanne M Murabito, Douglas P Kiel, Pei-Chien Tsai, Idil Yet, Jordana T Bell, Massimo Mangino, Toshiko Tanaka, Allan F McRae, Riccardo E Marioni, Peter M Visscher, Naomi R Wray, Ian J Deary, Morgan E Levine, Austin Quach, Themistocles Assimes, Philip S Tsao, Devin Absher, James D Stewart, Yun Li, Alex P Reiner, Lifang Hou, Andrea A Baccarelli, Eric A Whitsel, Abraham Aviv, Alexia Cardona, Felix R Day, Nicholas J Wareham, John R B Perry, Ken K Ong, Kenneth Raj, Kathryn L Lunetta, Steve Horvath
DNA methylation age is an accurate biomarker of chronological age and predicts lifespan, but its underlying molecular mechanisms are unknown. In this genome-wide association study of 9907 individuals, we find gene variants mapping to five loci associated with intrinsic epigenetic age acceleration (IEAA) and gene variants in three loci associated with extrinsic epigenetic age acceleration (EEAA). Mendelian randomization analysis suggests causal influences of menarche and menopause on IEAA and lipoproteins on IEAA and EEAA...
January 26, 2018: Nature Communications
https://www.readbyqxmd.com/read/29367468/dna-methylation-signatures-reflect-aging-in-patients-with-nonalcoholic-steatohepatitis
#3
Rohit Loomba, Yevgeniy Gindin, Zhaoshi Jiang, Eric Lawitz, Stephen Caldwell, C Stephen Djedjos, Ren Xu, Chuhan Chung, Robert P Myers, G Mani Subramanian, Zachary Goodman, Michael Charlton, Nezam H Afdhal, Anna Mae Diehl
A DNA methylation (DNAm) signature (the "Horvath clock") has been proposed as a measure of human chronological and biological age. We determined peripheral blood DNAm in patients with nonalcoholic steatohepatitis (NASH) and assessed whether accelerated aging occurs in these patients. DNAm signatures were obtained in patients with biopsy-proven NASH and stage 2-3 fibrosis. The DNAm profile from one test and two validation cohorts served as controls. Age acceleration was calculated as the difference between DNAm age and the predicted age based on the linear model derived from controls...
January 25, 2018: JCI Insight
https://www.readbyqxmd.com/read/29337038/back-to-the-future-epigenetic-clock-plasticity-towards-healthy-aging
#4
REVIEW
Ken Declerck, Wim Vanden Berghe
Aging is the most important risk factor for major human lifestyle diseases, including cancer, neurological and cardiometabolic disorders. Due to the complex interplay between genetics, lifestyle and environmental factors, some individuals seem to age faster than others, whereas centenarians seem to have a slower aging process. Therefore, a biochemical biomarker reflecting the relative biological age would be helpful to predict an individual's health status and aging disease risk. Although it is already known for years that cumulative epigenetic changes occur upon aging, DNA methylation patterns were only recently used to construct an epigenetic clock predictor for biological age, which is a measure of how well your body functions compared to your chronological age...
January 11, 2018: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29321814/the-epigenetic-clock-and-objectively-measured-sedentary-and-walking-behavior-in-older-adults-the-lothian-birth-cohort-1936
#5
Catharine R Gale, Riccardo E Marioni, Iva Čukić, Sebastien F Chastin, Philippa M Dall, Manon L Dontje, Dawn A Skelton, Ian J Deary
Background: Estimates of biological age derived from DNA-methylation patterns-known as the epigenetic clock-are associated with mortality, physical and cognitive function, and frailty, but little is known about their relationship with sedentary behavior or physical activity. We investigated the cross-sectional relationship between two such estimates of biological age and objectively measured sedentary and walking behavior in older people. Methods: Participants were 248 members of the Lothian Birth Cohort 1936...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29258983/genetic-and-epigeneticregulations-of-mammalian-circadian-rhythms
#6
Min Yue, Yu Yang, Gai Li Guo, Xi Ming Qin
The circadian clocks are vital to many organisms for their survival and adaption to the surrounding environment. More and more people are interested in the circadian clock and related researches. One of the key characteristics of this endogenous clock is its periodicity. Mechanisms underlying the mammalian circadian rhythms with ~24 h periodicity involve interlocked transcriptional and translational feedback loops. The circadian clock system in mammals consists of hierarchical structures, with the suprachiasmatic nucleus (SCN) as the central pacemaker and peripheral oscillators in other organs...
December 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/29235933/faster-ticking-rate-of-the-epigenetic-clock-is-associated-with-faster-pubertal-development-in-girls
#7
Alexandra M Binder, Camila Corvalan, Verónica Mericq, Ana Pereira, José Luis Santos, Steve Horvath, John Shepherd, Karin B Michels
Epigenetic age is an indicator of biological aging, capturing the impact of environmental and behavioral influences across time on cellular function. Deviance between epigenetic age and chronological age (AgeAccel) is a predictor of health. Pubertal timing has similarly been associated with cancer risk and mortality rate among females. We examined the association between AgeAccel and pubertal timing and adolescent breast composition in the longitudinal Growth and Obesity Cohort Study. AgeAccel was estimated in whole blood using the Horvath method at breast Tanner 2 (B2) and 4 (B4)...
December 13, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/29225347/accelerated-epigenetic-aging-and-mitochondrial-dna-copy-number-in-bipolar-disorder
#8
Gabriel R Fries, Isabelle E Bauer, Giselli Scaini, Mon-Ju Wu, Iram F Kazimi, Samira S Valvassori, Giovana Zunta-Soares, Consuelo Walss-Bass, Jair C Soares, Joao Quevedo
Bipolar disorder (BD) has been previously associated with accelerated aging; yet, the mechanisms underlying this association are largely unknown. The epigenetic clock has been increasingly recognized as a valuable aging marker, although its association with other biological clocks in BD patients and high-risk subjects, such as telomere length and mitochondrial DNA (mtDNA) copy number, has never been investigated. We included 22 patients with BD I, 16 siblings of BD patients, and 20 healthy controls in this analysis...
December 11, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29221677/epigenetic-regulation-of-biological-rhythms-an-evolutionary-ancient-molecular-timer
#9
REVIEW
Tyler J Stevenson
Biological rhythms are pervasive in nature, yet our understanding of the molecular mechanisms that govern timing is far from complete. The rapidly emerging research focus on epigenetic plasticity has revealed a system that is highly dynamic and reversible. In this Opinion, I propose an epigenetic clock model that outlines how molecular modifications, such as DNA methylation, are integral components for timing endogenous biological rhythms. The hypothesis proposed is that an epigenetic clock serves to maintain the period of molecular rhythms via control over the phase of gene transcription and this timing mechanism resides in all cells, from unicellular to complex organisms...
December 5, 2017: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/29190382/the-epigenetic-clock-and-telomere-length-are-independently-associated-with-chronological-age-and-mortality
#10
Riccardo E Marioni, Sarah E Harris, Sonia Shah, Allan F McRae, Thomas von Zglinicki, Carmen Martin-Ruiz, Naomi R Wray, Peter M Visscher, Ian J Deary
No abstract text is available yet for this article.
November 27, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29162648/biological-age-of-the-endometrium-using-dna-methylation
#11
Mia S Olesen, Anna Starnawska, Jonas Bybjerg-Grauholm, Alexandra P Bielfeld, Inge E Agerholm, Axel Forman, Michael T Overgaard, Mette Nyegaard
Age has a detrimental effect on reproduction and as an increasing number of women postpone motherhood, it is imperative to assess biological age in terms of fertility prognosis and optimizing fertility treatment individually. Horvath's epigenetic clock is a mathematical algorithm that calculates the biological age of human cells, tissues or organs based on DNA methylation levels. The clock however, was previously shown to be highly inaccurate for the human endometrium, most likely because of the hormonal responsive nature of this tissue...
November 21, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29155255/the-role-of-epigenetics-in-cardiovascular-health-and-aging-a-focus-on-physical-activity-and-nutrition
#12
REVIEW
Robert G Wallace, Laura C Twomey, Marc-Antoine Custaud, Jonathan Turner, Niall Moyna, Philip M Cummins, Ronan P Murphy
The cardiovascular system is responsible for transport of blood and nutrients to tissues, and is pivotal to the physiological health and longevity. Epigenetic modification is a natural, age-associated process resulting in highly contextualised gene expression with clear implications for cell differentiation and disease onset. Biological/epigenetic age is independent of chronological age, constituting a highly reflective snapshot of an individual's overall health. Accelerated vascular aging is of major concern, effectively lowering disease threshold...
November 16, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29155247/cells-have-sex-chromosomes-and-circadian-clocks-implications-for-organismal-level-functions
#13
Rae Silver
A great number of stakeholders have a keen interest in issues surrounding sex differences. These participants in the discourse often use the same evidence to draw opposite conclusions, with implications for individuals and society as a whole. One part of the maelstrom and associated emotionality derives from confounds between the concepts of "sex" vs. "gender", even among professionals. Here, the oft-repeated point is made that evidence for gender differences can't be derived from the animal research, once the generally accepted conception of gender as a process unique to humans, is acknowledged...
November 15, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29149257/eleven-telomere-epigenetic-clock-and-biomarker-composite-quantifications-of-biological-aging-do-they-measure-the-same-thing
#14
Daniel W Belsky, Terrie E Moffitt, Alan A Cohen, David L Corcoran, Morgan E Levine, Joseph A Prinz, Jonathan Schaefer, Karen Sugden, Benjamin Williams, Richie Poulton, Avshalom Caspi
The geroscience hypothesis posits that therapies to slow biological processes of aging can prevent disease and extend healthy years of life. To test such "gero-protective" therapies in humans, outcome measures are needed that can assess extension of disease-free lifespan. This need has spurred development of different methods to quantify biological aging. But different methods have not been systematically compared in the same humans. We implemented seven methods to quantify biological aging using repeated-measures physiological and genomic data in 964 middle-aged humans in the Dunedin Study...
November 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29139132/light-and-temperature-cues-multitasking-receptors-and-transcriptional-integrators
#15
REVIEW
Jorge J Casal, Julia I Qüesta
The combined information provided by light and temperature cues helps to optimise plant body architecture and physiology. Plants possess elaborate systems to sense and respond to these stimuli. Simultaneous perception of light and temperature by dual receptors such as phytochrome B and phototropin leads to immediate signalling convergence. Conversely, cue asynchronies initiate separate pathways and the information of the earliest cue is stored, awaiting the arrival of the later cue to control transcription...
November 15, 2017: New Phytologist
https://www.readbyqxmd.com/read/29129785/advances-in-hypoxia-inducible-factor-biology
#16
REVIEW
Hani Choudhry, Adrian L Harris
Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis and metabolic activation. Beyond this, HIF influences many other processes. Hypoxia, in part through HIF-dependent mechanisms, influences epigenetic factors, including DNA methylation and histone acetylation, which modulate hypoxia-responsive gene expression in cells. Hypoxia profoundly affects expression of many noncoding RNAs classes that have clinicopathological implications in cancer...
November 8, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/29128257/the-role-of-clock-genes-in-the-etiology-of-major-depressive-disorder
#17
REVIEW
Massimiliano Buoli, Marta Serati, Silvia Grassi, Laura Pergoli, Laura Cantone, A Carlo Altamura, Valentina Bollati
BACKGROUND: Circadian rhythms are largely dysregulated in Major Depressive Disorder (MDD). The present review provides a summary of the findings about the role of clock genes in the etiology of MDD. METHODS: A careful search of articles on Pubmed, PsycINFO, Isi Web of Knowledge was performed in order to obtain a comprehensive review about the topic. RESULTS: The studies reported contrasting results about the association of different single nucleotide polymorphisms (SNPs) in clock genes and MDD...
November 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29106308/sleep-quality-and-methylation-status-of-core-circadian-rhythm-genes-among-nurses-and-midwives
#18
Agnieszka Bukowska-Damska, Edyta Reszka, Pawel Kaluzny, Edyta Wieczorek, Monika Przybek, Shanbeh Zienolddiny, Beata Peplonska
ABSTARCT Poor sleep quality or sleep restriction is associated with sleepiness and concentration problems. Moreover, chronic sleep restriction may affect metabolism, hormone secretion patterns and inflammatory responses. Limited recent reports suggest a potential link between sleep deprivation and epigenetic effects such as changes in DNA methylation profiles. The aim of the present study was to assess the potential association between poor sleep quality or sleep duration and the levels of 5-methylcytosine in the promoter regions of PER1, PER2, PER3, BMAL1, CLOCK, CRY1 CRY2 and NPAS2 genes, taking into account rotating night work and chronotype as potential confounders or modifiers...
2017: Chronobiology International
https://www.readbyqxmd.com/read/29081695/aging-as-an-epigenetic-phenomenon
#19
REVIEW
Vasily V Ashapkin, Lyudmila I Kutueva, Boris F Vanyushin
INTRODUCTION: Hypermethylation of genes associated with promoter CpG islands, and hypomethylation of CpG poor genes, repeat sequences, transposable elements and intergenic genome sections occur during aging in mammals. Methylation levels of certain CpG sites display strict correlation to age and could be used as "epigenetic clock" to predict biological age. Multi-substrate deacetylases SIRT1 and SIRT6 affect aging via locus-specific modulations of chromatin structure and activity of multiple regulatory proteins involved in aging...
October 2017: Current Genomics
https://www.readbyqxmd.com/read/28986235/alpha-synuclein-epigenetics-mitochondria-metabolism-calcium-traffic-circadian-dysfunction-in-parkinson-s-disease-an-integrated-strategy-for-management
#20
REVIEW
Oliver T Phillipson
The motor deficits which characterise the sporadic form of Parkinson's disease arise from age-related loss of a subset of dopamine neurons in the substantia nigra. Although motor symptoms respond to dopamine replacement therapies, the underlying disease process remains. This review details some features of the progressive molecular pathology and proposes deployment of a combination of nutrients: R-lipoic acid, acetyl-l-carnitine, ubiquinol, melatonin (or receptor agonists) and vitamin D3, with the collective potential to slow progression of these features...
November 2017: Ageing Research Reviews
keyword
keyword
65336
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"