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JOURNAL ARTICLE
Jian Gu, Yue Qiao, Shuyan Cong
BACKGROUND: Previous observational studies have suggested a correlation between immune cells and Parkinson's disease (PD), yet specific investigations into the causal relationship between the two remain limited. This study aims to explore this potential causal relationship. METHODS: We utilized genome-wide association study (GWAS) data on immune cells and Parkinson's Disease, conducting a two-sample Mendelian randomization (MR) analysis using single nucleotide polymorphisms (SNPs)...
2024: Frontiers in Aging Neuroscience
#2
JOURNAL ARTICLE
Kyoko Hayakawa, Yan Zhou, Susan A Shinton
Human old aged unmutated chronic lymphocytic leukemia U-CLL are the TCL1+ ZAP70+ CD5+ B cells. Since CD5 makes the BCR signaling tolerance, ZAP70 increased in U-CLL not only TCL1+ alone. In mice, TCL1 (TCL1A) is the negative from neonate to old aged, as TC- . VH 8-12/Vk 21-5 is the anti-thymocyte/Thy-1 autoreactive ATA B cell. When ATA μκTg generation in mice, ATA B cells are the neonate generated CD5+ B cells in B-1, and in the middle age, CD5+ can be down or continuously CD5+ , then, old aged CLL/lymphoma generation with increased CD11b in TC- ZAP70- CD5- or TC- ZAP70+ CD5+ ...
April 3, 2024: Immunity & Ageing: I & A
#3
JOURNAL ARTICLE
Huang-Hong Zhao, Zhen Ma, Dong-Sheng Guan
BACKGROUND: Despite being one of the most prevalent sleep disorders, obstructive sleep apnea hypoventilation syndrome (OSAHS) has limited information on its immunologic foundation. The immunological underpinnings of certain major psychiatric diseases have been uncovered in recent years thanks to the extensive use of genome-wide association studies (GWAS) and genotyping techniques using high-density genetic markers ( e.g. , SNP or CNVs). But this tactic hasn't yet been applied to OSAHS...
March 6, 2024: World Journal of Clinical Cases
#4
JOURNAL ARTICLE
Wangchun Li, Hangyu Liu, Lijuan Gao, Yang Hu, Anna Zhang, Wenfeng Li, Guolong Liu, Weibin Bai, Yudai Xu, Chanchan Xiao, Jieping Deng, Wen Lei, Guobing Chen
Immune functional decline and remodeling accompany aging and frailty. It is still largely unknown how changes in the immune cellular composition differentiate healthy individuals from those become frail at a relatively early age. Our aim in this exploratory study was to investigate immunological changes from newborn to frailty, and the association between health statute and various immune cell subtypes. The participants analyzed in this study covered human cord blood cells and peripheral blood cells collected from young adults, healthy and frail old individuals...
March 6, 2024: Journal of Leukocyte Biology
#5
JOURNAL ARTICLE
Yunying Zhu, Qian Jiang, Chenshuang Lei, Qinhua Yu, Liannv Qiu
BACKGROUND: Allergic asthma is a type I allergic reaction mediated by serum Immunoglobulin E (IgE). B cell-mediated humoral immune response to allergens in the pathophysiology of allergic asthma have not been thoroughly elucidated. Peripheral helper T cells (Tph) and follicular helper T cells (Tfh) promote B cell differentiation and antibody production in inflamed tissues. OBJECTIVE: To investigate the roles of B cell subsets, Tph cell subsets and Tfh cell subsets in allergic immune responses...
February 29, 2024: BMC Pediatrics
#6
JOURNAL ARTICLE
Jia Song, Yidan Qin, Lin Wang, Wei Quan, Jing Xu, Jia Li, Jiajun Chen
Parkinson's disease (PD) is a neurodegenerative disorder with extensive involvement of motor symptoms, imposing a heavy economic burden on patients and society. B lymphocytes, a group of immune cells associated with humoral immunity, have been shown to be involved in the pathogenesis of PD. However, the causal relationship and potential pathogenic effects of B cell in PD remain unclear. Based on the three core hypotheses of the Mendelian randomization (MR) study, we explored causal associations between 190 B-cell immunological traits and 482,730 European individuals (Ncase = 33,674, Ncontrol = 449,056) from genome wide association studies by means of the two-sample bidirectional MR method...
February 2, 2024: Scientific Reports
#7
JOURNAL ARTICLE
Yuchang Fei, Huan Yu, Yulun Wu, Shanshan Gong
BACKGROUND: Ankylosing spondylitis (AS) is one of several disorders known as seronegative spinal arthritis (SpA), the origin of which is unknown. Existing epidemiological data show that inflammatory and immunological factors are important in the development of AS. Previous research on the connection between immunological inflammation and AS, however, has shown inconclusive results. METHODS: To evaluate the causal association between immunological characteristics and AS, a bidirectional, two-sample Mendelian randomization (MR) approach was performed in this study...
January 16, 2024: Arthritis Research & Therapy
#8
JOURNAL ARTICLE
Thalyta Nery Carvalho Pinto, Cibele Cristine Berto Marques da Silva, Regina Maria Carvalho Pinto, Alberto José da Silva Duarte, Gil Benard, Juliana Ruiz Fernandes
Several disturbances in T-cell mediated immunity have been described during aging, but immunosenescence of the B-cell compartment is less well elucidated. The peripheral blood B-cell compartment (CD19+) can be split into six main subpopulations according to the cell surface markers IgD, CD27, CD24, and CD38: Transitional, naïve, unswitched, switched, double negative and plasmablasts. We thus aimed to verify whether shifts in these subsets occur during healthy and pathological aging. We recruited three groups of aged people (> 60 years old), healthy, COPD patients, and smokers without altered pulmonary function test, and a fourth group of individuals 18-40 years old (youngs)...
December 29, 2023: GeroScience
#9
JOURNAL ARTICLE
Panaparambil Azis Suhana, Lata Kusum, Jain Vij Shruti, Gopinathan Pillai Sreekanth, Damodaran Bijukumar, R T Shaji Kumar, K C Muraleedharan, Subhash Kaushik
BACKGROUND: COVID-19 is a recent major public health concern caused by the SARS-CoV-2 virus, with approximately 44.6 million COVID-19-positive cases and 530,000 deaths in India (as of February 1, 2023). The COVID-19 vaccination drive in India was initiated in January 2021; however, an effective preventive strategy with high efficacy and immunological safety remains elusive. OBJECTIVE: The aim of this study is to assess the immunogenic responses of Arsenicum album 30CH (AA30CH) as COVID-19 prophylaxis, including assessment of immunological markers, innate and acquired immune responses, COVID-19 symptoms, and its associated antibody responses...
October 16, 2023: JMIR Research Protocols
#10
JOURNAL ARTICLE
Sarvpreet Kaur, Nikita Kundu, Taniya Sharma, Jadala Shankaraswamy, Sarika Saxena
Regulatory regions in the human genome, enriched in guanine-rich DNA sequences have a remarkable enrichment of G-rich sequences having a tendency to fold into G-quadruplex structures. To identify the G-quadruplex forming motifs in regulatory regions of stem cell markers, gene sequences of various stem cell markers were downloaded and analyzed to see the abundance of G-rich sequences. We observed the enrichment of G-rich sequences in stem cell markers (CD13, CD19, CD24 and CD38) which could possibly play a critical role in its regulation...
October 14, 2023: Journal of Biomolecular Structure & Dynamics
#11
JOURNAL ARTICLE
Lude Moekotte, Jonas J W Kuiper, Sanne Hiddingh, Xuan-Thanh-An Nguyen, Camiel J F Boon, L Ingeborgh van den Born, Joke H de Boer, Maria M van Genderen
PURPOSE: Eye inflammation may occur in patients with inherited retinal dystrophies (IRDs) and is seen frequently in IRDs associated with mutations in the CRB1 gene. The purpose of this study was to determine the types of inflammatory cells involved in IRDs, by deep profiling the composition of peripheral blood mononuclear cells of patients with a CRB1-associated IRD. METHODS: This study included 33 patients with an IRD with confirmed CRB1 mutations and 32 healthy controls...
October 3, 2023: Investigative Ophthalmology & Visual Science
#12
JOURNAL ARTICLE
Marta Magatti, Francesca Pischiutta, Fabrizio Ortolano, Anna Pasotti, Enrico Caruso, Anna Cargnoni, Andrea Papait, Franco Capuzzi, Tommaso Zoerle, Marco Carbonara, Nino Stocchetti, Stefano Borsa, Marco Locatelli, Elisa Erba, Daniele Prati, Antonietta R Silini, Elisa R Zanier, Ornella Parolini
BACKGROUND: Traumatic brain injury (TBI) is a leading cause of death and long-term disability worldwide. In addition to primary brain damage, systemic immune alterations occur, with evidence for dysregulated immune responses in aggravating TBI outcome and complications. However, immune dysfunction following TBI has been only partially understood, especially in the elderly who represent a substantial proportion of TBI patients and worst outcome. Therefore, we aimed to conduct an in-depth immunological characterization of TBI patients, by evaluating both adaptive (T and B lymphocytes) and innate (NK and monocytes) immune cells of peripheral blood mononuclear cells (PBMC) collected acutely (< 48 h) after TBI in young (18-45 yo) and elderly (> 65 yo) patients, compared to age-matched controls, and also the levels of inflammatory biomarkers...
August 12, 2023: Immunity & Ageing: I & A
#13
JOURNAL ARTICLE
Bishun Deng, Li Deng, Miao Liu, Ziling Zhao, Huijie Huang, Xiaoxin Tu, Enyu Liang, Ruimin Tian, Xiaowan Wang, Rongrong Wang, Haibiao Lin, Yongyi Yu, Anping Peng, Peng Xu, Kun Bao, Min He
CD19+ CD24hi CD38hi regulatory B cells exert immunosuppressive functions by producing IL-10, but their role in idiopathic membranous nephropathy (IMN) remains elusive. Here, we investigated the frequency and functional changes of circulating CD19+ CD24hi CD38hi B cells and evaluated the correlation of CD19+ CD24hi CD38hi B cells with clinical features and T helper cell subsets in IMN patients. Compared with healthy controls (HCs), IMN patients showed an increased frequency of CD19+ CD24hi CD38hi B cells, but a significant reduction in the percentage of CD19+ CD24hi CD38hi B cells was observed 4 weeks after cyclophosphamide treatment...
August 6, 2023: Immunology Letters
#14
JOURNAL ARTICLE
Esther Clavero, José Manuel Sanchez-Maldonado, Angelica Macauda, Rob Ter Horst, Belém Sampaio-Marques, Artur Jurczyszyn, Alyssa Clay-Gilmour, Angelika Stein, Michelle A T Hildebrandt, Niels Weinhold, Gabriele Buda, Ramón García-Sanz, Waldemar Tomczak, Ulla Vogel, Andrés Jerez, Daria Zawirska, Marzena Wątek, Jonathan N Hofmann, Stefano Landi, John J Spinelli, Aleksandra Butrym, Abhishek Kumar, Joaquín Martínez-López, Sara Galimberti, María Eugenia Sarasquete, Edyta Subocz, Elzbieta Iskierka-Jażdżewska, Graham G Giles, Malwina Rybicka-Ramos, Marcin Kruszewski, Niels Abildgaard, Francisco García Verdejo, Pedro Sánchez Rovira, Miguel Inacio da Silva Filho, Katalin Kadar, Małgorzata Razny, Wendy Cozen, Matteo Pelosini, Manuel Jurado, Parveen Bhatti, Marek Dudzinski, Agnieszka Druzd-Sitek, Enrico Orciuolo, Yang Li, Aaron D Norman, Jan Maciej Zaucha, Rui Manuel Reis, Miroslaw Markiewicz, Juan José Rodríguez Sevilla, Vibeke Andersen, Krzysztof Jamroziak, Kari Hemminki, Sonja I Berndt, Vicent Rajkumar, Grzegorz Mazur, Shaji K Kumar, Paula Ludovico, Arnon Nagler, Stephen J Chanock, Charles Dumontet, Mitchell J Machiela, Judit Varkonyi, Nicola J Camp, Elad Ziv, Annette Juul Vangsted, Elizabeth E Brown, Daniele Campa, Celine M Vachon, Mihai G Netea, Federico Canzian, Asta Försti, Juan Sainz
Multiple myeloma (MM) arises following malignant proliferation of plasma cells in the bone marrow, that secrete high amounts of specific monoclonal immunoglobulins or light chains, resulting in the massive production of unfolded or misfolded proteins. Autophagy can have a dual role in tumorigenesis, by eliminating these abnormal proteins to avoid cancer development, but also ensuring MM cell survival and promoting resistance to treatments. To date no studies have determined the impact of genetic variation in autophagy-related genes on MM risk...
May 9, 2023: International Journal of Molecular Sciences
#15
JOURNAL ARTICLE
Hana M Zegallai, Kangmin Duan, Grant M Hatch
Barth Syndrome (BTHS) is a rare X-linked genetic disease caused by a mutation in the TAFAZZIN gene, which codes for the protein tafazzin involved in cardiolipin remodeling. Approximately 70% of patients with BTHS exhibit severe infections due to neutropenia. However, neutrophils from BTHS patients have been shown to exhibit normal phagocytosis and killing activity. B lymphocytes play a crucial role in the regulation of the immune system and, when activated, secrete cytokines known to attract neutrophils to sites of infection...
May 16, 2023: Biology
#16
JOURNAL ARTICLE
Wei Li, Binglei Zhang, Weijie Cao, Wenli Zhang, Tiandong Li, Lina Liu, LinPing Xu, Fengcai Gao, Yanmei Wang, Fang Wang, Haizhou Xing, Zhongxing Jiang, Jianxiang Shi, Zhilei Bian, Yongping Song
BACKGROUND: BCMA CAR-T is highly effective for relapsed/refractory multiple myeloma(R/R-MM) and significantly improves the survival of patients. However, the short remission time and high relapse rate of MM patients treated with BCMA CAR-T remain bottlenecks that limit long-term survival. The immune microenvironment of the bone marrow (BM) in R/R-MM may be responsible for this. The present study aims to present an in-depth analysis of resistant mechanisms and to explore potential novel therapeutic targets for relapse of BCMA CAR-T treatment via single-cell RNA sequencing (scRNA-seq) of BM plasma cells and immune cells...
May 8, 2023: Experimental Hematology & Oncology
#17
JOURNAL ARTICLE
Sara Abdelal Mohammed, Helal F Hetta, Asmaa M Zahran, Mohammed E M Tolba, Rasha A H Attia, Hosny M Behnsawy, Abdelazeem M Algammal, Gaber El-Saber Batiha, Ahmed Qasem Mohammed, Alzahraa Abdelraouf Ahmad
BACKGROUND: The function of different populations of the immune system in bladder cancer (BCa) is well established. However, the cohesive role of the immune cell profile of schistosomal BCa at systemic and tissue levels is still lacking, especially in endemic countries. The balance hypothesized between protumorigenic and antitumor molecules determines the prognosis of tumor progression. This study aimed to investigate the frequency of T cell subsets at both blood and tumor tissue, regulatory T(Treg), regulatory B cells (Breg) and proinflammatory cytokines in S...
April 2023: PLoS Neglected Tropical Diseases
#18
JOURNAL ARTICLE
Noha A Hassuna, Sahar Sh Hussien, Mohammed Abdelhakeem, Ahmed Aboalela, Elham Ahmed, Soha S Abdelrahim
BACKGROUND: Helicobacter pylori (H. pylori) infection is linked with a wide variety of diseases and was reported in more than half of the world's population. Chronic H. pylori infection and its final clinical outcome depend mainly on the bacterial virulence factors and its ability to manipulate and adapt to human immune responses. Bregs blood levels have been correlated with increased bacterial load and infection chronicity, especially Gram-negative bacterial infection. This study aimed to identify prevalence and virulence factors of chronic H...
January 20, 2023: Helicobacter
#19
JOURNAL ARTICLE
Subhadip Pati, Sumon Mukherjee, Saikat Dutta, Aharna Guin, Dia Roy, Sayantan Bose, Silpita Paul, Sudipto Saha, Sankar Bhattacharyya, Pratyush Datta, Jayati Chakraborty, Diptendra K Sarkar, Gaurisankar Sa
B cells are an essential component of humoral immunity. Their primary function is to mount antigen-specific antibody responses to eliminate pathogens. Despite an increase in B-cell number, we found that serum-IgG levels were low in patients with breast cancer. To solve this conundrum, we used high-dimensional flow cytometry to analyze the heterogeneity of B-cell populations and identified a tumor-specific CD19+CD24hiCD38hi IL10-producing B regulatory (Breg)-cell subset. Although IL10 is a Breg-cell marker, being an intracellular protein, it is of limited value for Breg-cell isolation...
March 1, 2023: Cancer Immunology Research
#20
JOURNAL ARTICLE
Chunmei Wang, Huihui Xu, Rui Gao, Fengying Leng, Fangjie Huo, Yinzhen Li, Siting Liu, Mingzheng Xu, Jianwen Bai
BACKGROUND: Sepsis still remains a major challenge in intensive care medicine with unacceptably high mortality among patients with septic shock. Due to current limitations of human CD19+ CD24hi CD38hi Breg cells (Bregs) studies among sepsis, here, we tried to evaluate Bregs in severity and prognostic value in patients with sepsis. METHODS: Peripheral blood from 58 patients with sepsis and 22 healthy controls was analyzed using flow cytometry to evaluate the frequency and number of Bregs...
November 10, 2022: BMC Immunology
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