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https://www.readbyqxmd.com/read/28806513/intraperitoneal-delivery-of-cisplatin-via-a-hyaluronan-based-nanogel-in-situ-crosslinkable-hydrogel-hybrid-system-for-peritoneal-dissemination-of-gastric-cancer
#1
Seiichi Ohta, Shota Hiramoto, Yuki Amano, Shigenobu Emoto, Hironori Yamaguchi, Hironori Ishigami, Joji Kitayama, Taichi Ito
Intraperitoneal administration of chemotherapeutics is expected for the treatment of peritoneally disseminated gastric cancer, because of poor migration of the drugs from the systemic circulation to the peritoneal cavity. In this study, for intraperitoneal delivery of cisplatin (CDDP), we developed a hyaluronan (HA)-based hybrid system in which CDDP-loaded HA nanogels were either physically encapsulated in or chemically conjugated to injectable HA hydrogels. Physical encapsulation enabled sustained release of HA nanogels from the HA hydrogel matrix for over a week...
August 14, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28806492/evaluation-of-gastric-and-bladder-tonometry-as-indicators-of-tissue-perfusion-in-induced-hypotension-in-dogs
#2
Juan Morgaz, Lidia Espigares-Rodríguez, Pilar Muñoz-Rascón, Rocío Navarrete, Jose Andrés Fernández-Sarmiento, María Del Mar Granados Machuca
OBJECTIVE: To evaluate the use of gastric (PgCO2 ) and bladder (PbCO2 ) tonometry for assessing tissue hypoperfusion in dogs during sevoflurane-induced hypotension, and to compare these measurements with delivery of oxygen, arterial oxygen content, and plasma lactate concentration. DESIGN: Prospective experimental trial. SETTING: University veterinary teaching hospital. ANIMALS: Fourteen adult Beagle dogs. INTERVENTIONS: Anesthetic induction was performed by mask with sevoflurane and oxygen...
August 14, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28806319/transient-segmental-enhancement-of-pyogenic-liver-abscess-a-comparison-between-contrast-enhanced-ultrasound-and-computed-tomography
#3
Kun Sun, Wei Zhu, Yan Luo, Yongzhong Li, Xiang Zhou
OBJECTIVE: This study aimed to investigate the correlation between the transient segmental enhancement (TSE) of liver abscesses on contrast-enhanced ultrasound (CEUS) imaging and contrast-enhanced computed tomography (CT) scans. METHODS: In total, 42 abscesses in 38 patients were evaluated with real-time CEUS and contrast-enhanced CT imaging. The CT imaging and CEUS examinations were performed within one to 2 days of each other in all cases. The initial reports of the observations of TSE on CEUS scans were correlated later with the findings of TSE on contrast-enhanced CT images...
August 12, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28806295/splenules-presenting-as-incidental-gastric-fundic-masses-on-endoscopy
#4
Ammar Khayat, Alfonso M Martinez
No abstract text is available yet for this article.
August 11, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28806271/luminal-chemosensing-in-the-gastroduodenal-mucosa
#5
Izumi Kaji, Jonathan D Kaunitz
PURPOSE OF REVIEW: We report recently published knowledge regarding gut chemosensory mechanisms focusing on nutrient-sensing G protein-coupled receptors (GPCRs) expressed on gut enteroendocrine cells (EECs), tuft cells, and in afferent nerves in the gastroduodenal mucosa and submucosa. RECENT FINDINGS: Gene profiling of EECs and tuft cells have revealed expression of a variety of nutrient-sensing GPCRs. The density of EEC and tuft cells is altered by luminal environmental changes that may occur following bypass surgery or in the presence of mucosal inflammation...
August 12, 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28806259/serendipitous-discovery-of-isolated-gastric-metastases-from-adenocarcinoma-of-the-lung-on-staging-18f-fdg-pet-ct
#6
Punit Sharma, Amit Dutt Dwary, Enam Murshed Khan
Gastric metastasis from lung cancer is rare. We here present the case of a 59-year-old man with lung adenocarcinoma where isolated gastric metastases were discovered on staging F-FDG PET-CT, confirmed with endoscopy and biopsy.
August 12, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28805888/development-of-small-intestinal-enzyme-activities-and-their-relationship-with-some-gut-regulatory-peptides-in-grazing-sheep
#7
C L Wang, X Lang, P J Wu, D P Casper, F D Li
Growth depends on an animal's capacity to digest and assimilate ingested nutrients, and insufficient supply and impairment will constrain lamb growth. Eight groups of Alpine Finewool lambs were harvested on 0, 3, 7, 14, 21, 28, 42, and 56 d to measure pH and enzymatic activities in the duodenum, proximal jejunum, middle jejunum, distal jejunum, and ileum mucosa or digesta. From the duodenum to the ileum the pH of intestinal mucosa and digesta increased, whereas pH changed very little with age. The trypsin, chymotrypsin, lipase, lactase, and α-amylase activities observed at birth decreased by d 3, followed by a nonuniform enzymatic response in the small intestine...
August 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28805287/nongenetically-modified-lactococcus-lactis-adjuvanted-vaccination-enhanced-innate-immunity-against-helicobacter-pylori
#8
Wei Liu, Zhoulin Tan, Hai Liu, Zhiqin Zeng, Shuanghui Luo, Huimin Yang, Lufeng Zheng, Tao Xi, Yingying Xing
BACKGROUND: Gram-positive enhancer matrix particles (GEM) produced by Lactococcus lactis can enhance vaccine-induced immune response. However, the mechanism under which this adjuvant mounts the efficacy of orally administered vaccines remains unexplored. MATERIALS AND METHODS: We used a prophylactic mice model to investigate the mechanism of GEM-adjuvanted vaccination. Helicobacter pylori urease-specific antibody response was monitored and detected in murine serum by ELISA...
August 14, 2017: Helicobacter
https://www.readbyqxmd.com/read/28805239/a-comparison-of-gastric-emptying-of-soluble-solid-meals-and-clear-fluids-matched-for-volume-and-energy-content-a-pilot-crossover-study
#9
T Okabe, H Terashima, A Sakamoto
We previously demonstrated that the gastric emptying time of different liquids with the same volume mainly depended on their energy content, regardless of differences in composition. In this crossover study, we investigated whether the same applies when soluble solid foods are ingested with water. Ten healthy volunteers ingested one of five test diets consisting of two test meals (Calorie Mate(®) 100 and 200 kcal) and three test solutions (water and glucose solutions of 100 and 200 kcal), each given in a volume of 400 ml, and then underwent ultrasonography to measure the gastric antral cross-sectional area every 10 min for 120 min...
August 14, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28805238/ultrasound-assessment-of-gastric-contents-in-children-undergoing-elective-ear-nose-and-throat-surgery-a-prospective-cohort-study
#10
F-P Desgranges, A-C Gagey Riegel, C Aubergy, M de Queiroz Siqueira, D Chassard, L Bouvet
Ultrasound examination of the gastric antrum allows reliable assessment of gastric contents and volume. Postoperative assessment of gastric contents before recovery from anaesthesia could help the physician to choose the most appropriate extubation technique after surgery in children. In this prospective observational study, we assessed whether significant changes occurred in gastric contents during the intra-operative period in children undergoing elective ear, nose and throat (ENT) surgery. Children aged between six months and 16 years were recruited consecutively...
August 14, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28805208/gastric-adenocarcinoma
#11
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
June 1, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28805143/a-pre-term-infant-of-32-weeks-gestation-with-congenital-tuberculosis-treated-successfully-with-antituberculosis-chemotherapy
#12
Xiaoyi Fang, Ruizhi Mai, Jizhong Guo, Niyang Lin
An infant of 32 weeks gestation was separated from her mother at birth for treatment of hyaline membrane disease and, on recovery, was cared for by adoptive parents. At 25 days, she was treated for pneumonia with immunoglobulins and multiple antibiotics and appeared to respond. Her symptoms recurred at 8 weeks and tuberculosis was confirmed by detection in an acid-fast bacilli smear of gastric aspirate. Her mother presented with disseminated tuberculosis with meningitis 1 month after delivery. Criteria for the diagnosis of congenital tuberculosis in the infant were confirmed...
August 14, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28804801/pancreatic-enzyme-supplementation-after-gastrectomy-for-gastric-cancer-a-randomized-controlled-trial
#13
Marco Catarci, Manuele Berlanda, Giovanni Battista Grassi, Francesco Masedu, Stefano Guadagni
BACKGROUND: Gastrectomy for gastric cancer is a significant cause of secondary exocrine pancreatic insufficiency. Pancreatic enzyme replacement therapy may influence nutritional status and quality of life after gastrectomy, but the pertinent clinical research to date remains controversial. A randomized controlled trial to test this hypothesis was carried out. METHODS: After gastrectomy, 43 patients with gastric cancer were randomly assigned to a normal diet (Normal-d; n = 21) or to a pancreatic enzyme supplementation diet (PES-d; n = 22) and were followed up during a 12-month period, assessing nutritional status and quality of life through body mass index (BMI), instant nutritional assessment (INA) class status, serum pre-albumin (SPA) values, and GastroiIntestinal Quality of Life Index (GIQLI)...
August 14, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28804629/clinical-presentation-and-treatment-of-gastric-metastasis-from-other-malignancies-of-solid-organs
#14
Tsutomu Namikawa, Eri Munekage, Maho Ogawa, Toyokazu Oki, Masaya Munekage, Hiromichi Maeda, Hiroyuki Kitagawa, Takeki Sugimoto, Michiya Kobayashi, Kazuhiro Hanazaki
The aim of the present study was to analyze the clinicopathologic features and treatment outcomes of gastric metastasis from other malignancies of solid organs. A review was conducted of patients with metastatic tumors in the stomach from other malignancies of solid organs detected endoscopically at the Department of Surgery, Kochi Medical School, from January 1991 to December 2015. Seven patients (four men and three women), with a median age of 64 years (range, 42-71 years), had metastatic gastric tumors. Median tumor size was 7...
August 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28804625/the-relationship-between-tumor-necrosis-factor-%C3%AE-polymorphisms-and-gastric-cancer-risk-an-updated-meta-analysis
#15
Wenxian Zheng, Shuisheng Zhang, Shenfeng Zhang, Li Min, Yihong Wang, Jian Xie, Yong Hou, Xiufang Tian, Jian Cheng, Kun Liu, Deguo Xu, Xinshuang Yu, Zhen Liu, Yajuan Lv, Ning Liang, Jiandong Zhang, Fengjun Liu, Yuan Tian
The aim of the present study was to evaluate the relationship between tumor necrosis factor-α (TNF-α) and the development of gastric cancer, and to investigate whether it can be used as a biological marker for gastric cancer. In the current study, a new meta-analysis was performed to assess the association between TNF-α gene polymorphisms and gastric cancer susceptibility. Subgroup analyses based on ethnicity, control population source and non-cardia cancers were also conducted. Summary odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model...
August 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28804556/anti-tumor-efficacy-evaluation-of-a-novel-monoclonal-antibody-targeting-neutral-amino-acid-transporter-asct2-using-patient-derived-xenograft-mouse-models-of-gastric-cancer
#16
Noriyuki Kasai, Aya Sasakawa, Kenta Hosomi, Tze Wei Poh, Bernadette Lynn Chua, Wei Peng Yong, Jimmy So, Shing Leng Chan, Richie Soong, Koji Kono, Toshihiko Ishii, Kazuya Yamano
ASC amino acid transporter 2 (ASCT2), also known as solute linked carrier family 1 member A5 (SLC1A5) is a Na+-dependent glutamine/neutral amino acid transporter. ASCT2 acts as a high-affinity transporter of L-glutamine (Gln) and has been reported to be up-regulated in a variety of cancerous tissues including stomach, liver, and kidney. In this study, we evaluated anti-tumor efficacy of a novel anti-ASCT2 humanized monoclonal antibody, KM8094, which has a neutralizing activity against glutamine uptake, as a therapeutic antibody against gastric cancer and explored clinical predictive biomarker candidates by utilizing patient-derived xenograft (PDX) mouse models...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28803743/gastric-antral-vascular-ectasia-presents-as-a-polypoid-mass-in-a-patient-with-cirrhosis
#17
Catherine Hudson, Eric Fontenot, Stephen Landreneau
No abstract text is available yet for this article.
August 10, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28803742/gastric-cardia-lesion-with-abnormal-volumetric-laser-endomicroscopy-imaging
#18
Nina Gupta, Vani Konda, Uzma Siddiqui
No abstract text is available yet for this article.
August 10, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28803707/patients-reasons-for-and-against-undergoing-roux-en-y-gastric-bypass-adjustable-gastric-banding-and-vertical-sleeve-gastrectomy
#19
Melissa Opozda, Gary Wittert, Anna Chur-Hansen
BACKGROUND: The most common bariatric procedures, Roux-en-Y gastric bypass (RYGB), adjustable gastric banding (LAGB), and sleeve gastrectomy (SG), generally induce significant weight loss and health improvements. However, little is known about how patients decide which procedure to undergo. OBJECTIVE: Investigate patients' reasons for and against undergoing RYGB, LAGB, and SG. SETTING: Online questionnaire. METHODS: Data were analyzed from 236 Australian adults with current RYGB (15...
July 15, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28803655/usefulness-of-pa32540-in-protecting-the-gastric-layer-while-providing-secondary-prevention-for-coronary-artery-disease
#20
REVIEW
Deepthi Kagolanu, Najia Sayedy, Syed Haseeb, Shivani Shah, Paul Lam, Swapna Munnangi, Prakash Viswanathan, Kent Stephenson
Aspirin has been the mainstay for secondary prevention of coronary artery disease to decrease early recurrence and severity of recurrent cardiovascular events. However, an increase in gastrointestinal bleeding due to aspirin is preventing many patients from adhering to this daily regimen. PA32540, a combination pill with aspirin and omeprazole, is a newly emerging intervention that has the potential to reinforce patient compliance with the aspirin regimen due to fewer gastrointestinal adverse effects. This systematic review assessed three recent phase 3 clinical trials investigating the safety and efficacy of PA32540...
July 14, 2017: American Journal of Cardiology
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