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https://www.readbyqxmd.com/read/28330081/emerging-cam-ziziphus-nummularia-with-in-vivo-sedative-hypnotic-antipyretic-and-analgesic-attributes
#1
Abdur Rauf, Jawad Ali, Haroon Khan, Mohammad S Mubarak, Seema Patel
Ziziphus nummularia from Rhamnaceae family is traditionally used for sedative-hypnotic, antipyretic and analgesic purposes; however, scientific validations are lacking. This in vivo study was undertaken to verify the above ameliorative properties of Z. nummularia root methanolic extract. Various fractions of the extract were assayed on Balb/c mice by open field, Brewer's yeast-induced hyperthermia and acetic acid-induced writhing experiments. The significance of the outcomes was analyzed with statistical tests...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28317769/protective-ability-against-oxidative-stress-of-brewers-spent-grain-protein-hydrolysates
#2
Elsa F Vieira, Diana Dias da Silva, Helena Carmo, Isabel M P L V O Ferreira
The protein fraction of Brewers' spent grain (BSG) was used as substrate to obtain hydrolysates with antioxidant activity. Three enzymatic approaches were applied: brewer's spent yeast (BSY) proteases, Neutrase® and Alcalase®, at the same proteolytic activity (1U/mL), using an enzyme/substrate ratio of 10:100 (v/v), at 50°C, 4h. Total Phenolic Content (TPC) and Ferric Ion Reducing Antioxidant Power (FRAP) of hydrolysates and fractions <10kDa and <3kDa were assayed. Additionally, the protective ability of <10kDa fractions against oxidative stress on Caco-2 and HepG2 cells was investigated...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28282294/in-vivo-analgesic-antipyretic-and-anti-inflammatory-potential-of-leaf-extracts-and-fractions-of-eria-javanica
#3
N M Mahmudul Alam Bhuiya, Mahmud Hasan, Zobaer Al Mahmud, Nazmul Qais, Mohammad Shah Hafez Kabir, Farhan Ahmed, Mir Muhammad Nasir Uddin
Background The objective of the study was to evaluate the antinociceptive, antipyretic and anti-inflammatory activities of ethanolic extract, methanolic extract and n-hexane and chloroform-soluble fractions of methanolic extract of Eria javanica leaves in animal model (rat and mice). Methods The anti-nociceptive potentials of the extracts were studied using the acetic acid-induced writhing test in mice and the antipyretic activity was investigated using yeast-induced pyrexia in rats. Anti-inflammatory activity test was done on rats at a dose by using carrageenan-induced paw edema test...
March 1, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28242466/elucidation-of-trna-cytochrome-c-interactions-through-hydrogen-deuterium-exchange-mass-spectrometry
#4
Yi-Ting Lo, Hung-Wei Huang, Yi-Chuan Huang, Jui-Fen Chan, Yuan-Hao Howard Hsu
Cytochrome c (cyt c) is a mitochondrial protein responsible for transferring electrons between electron transport chain complexes III and IV. The release of cyt c from the mitochondria has been considered as a commitment step in intrinsic apoptosis. Transfer RNA (tRNA) has recently been found to interact with the released cyt c to prevent the formation of the apoptosome complex, thus preventing cell apoptosis. To understand the molecular basis of tRNA-cyt c interactions, we applied hydrogen/deuterium exchange mass spectrometry (HDXMS) to analyze the interactions between tRNA and cyt c...
February 27, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28239492/performance-of-clarias-gariepinus-fed-dried-brewer-s-yeast-saccharomyces-cerevisiae-slurry-in-replacement-for-soybean-meal
#5
Shola Gabriel Solomon, Gabriel Arome Ataguba, Gabriel Enemona Itodo
Following disparity of earlier results, this study tested the performance of African catfish Clarias gariepinus fed dried brewer's yeast slurry meal (DBYM) based diets. Fingerlings of C. gariepinus with pooled mean initial weight of 1.58 ± 0.01 g were stocked in hapas (1 m × 1 m × 1 m) immersed in an earthen pond at a density of 15 fish per cage. Five diets with increasing substitution of soybean meal with 25%, 50%, 75%, and 100% of dried brewer's yeast and a control without dried brewer's yeast (0% substitution) were evaluated for 8 weeks...
2017: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/28154948/reduced-production-of-diacetyl-by-overexpressing-bdh2-gene-and-ilv5-gene-in-yeast-of-the-lager-brewers-with-one-ilv2-allelic-gene-deleted
#6
Ting-Ting Shi, Ping Li, Shi-Jia Chen, Ye-Fu Chen, Xue-Wu Guo, Dong-Guang Xiao
Diacetyl causes an unwanted buttery off-flavor in lager beer. The production of diacetyl is reduced by modifying the metabolic pathway of yeast in the beer fermentation process. In this study, BDH2 and ILV5 genes, coding diacetyl reductase and acetohydroxy acid reductoisomerase, respectively, were expressed using a PGK1 promoter in Saccharomyces cerevisiae, which deleted one ILV2 allelic gene. Diacetyl contents and fermentation performances were examined and compared. Results showed that the diacetyl content in beer was remarkably reduced by 16...
February 2, 2017: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28078531/yeast-mixture-of-liquid-beer-and-cassava-pulp-with-rice-straw-for-the-growth-of-dairy-heifers
#7
Sukanya Kamphayae, Hajime Kumagai, Patima Butcha, Viroj Ritruechai, Supachai Udchachon
This study was conducted to determine the effects of mixtures of liquid brewer's yeast (LBY) and cassava pulp (CVP) with rice straw (RS) on feed intake, digestibility, rumen fermentation, and growth of dairy heifers. Sixteen Holstein crossbred heifers (13.8 ± 1.6 months old, 210 ± 23 kg body weight (BW)) were randomly allocated to four feeding treatments with four replications, which were 0:0:100 (RS), 0:70:30 (0%LBY), 20:50:30 (20%LBY), and 50:20:30 (50%LBY), respectively, for LBY/CVP/RS on a fresh matter basis...
March 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/27780137/anti-oxidant-anti-inflammatory-analgesic-and-antipyretic-activities-of-grapevine-leaf-extract-vitis-vinifera-in-mice-and-identification-of-its-active-constituents-by-lc-ms-ms-analyses
#8
Bakhta Aouey, Amira Mahjoubi Samet, Hamadi Fetoui, Monique S J Simmonds, Mohamed Bouaziz
ETHNOPHARMACOLOGICAL RELEVANCE: The leaves of Vitis vinifera is used in traditional medicine for diarrhea, hepatitis and stomachaches. The objective of this study was to investigate the anti-oxidant, anti-inflammatory, analgesic and antipyretic properties of the hydroalcoholic leaf extract of Vitis vinifera (EVV) on experimental models to provide scientific basis for its use. MATERIALS AND METHODS: The EVV was chemically characterized by LC-MS/MS analyses. The in vitro antioxidant activities of the EVV extract were measured using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay and Ferric reducing antioxidant power assay (FRAP)...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27633830/the-fifth-annual-sc2-0-and-synthetic-genomes-conference-synthetic-genomes-in-high-gear
#9
Roy S K Walker, Yizhi Cai
The Sc2.0 project is perhaps the largest synthetic biology project in the public domain, and ultimately aims to construct a new version of the humble brewer's yeast, Saccharomyces cerevisiae. Each year, the Sc2.0 consortium gather to discuss progress in this ambitious project and highlight new developments at the forefront of synthetic genome engineering. This viewpoint summarizes some of the key moments of the 2016 conference, including updates on the Sc2.0 project itself, mammalian synthetic biology, DNA assembly automation, HGP-Write and a panel discussion on the social and ethical perspectives of synthetic biology...
September 16, 2016: ACS Synthetic Biology
https://www.readbyqxmd.com/read/27629605/genomics-history-of-brewer-s-yeast-revealed
#10
(no author information available yet)
No abstract text is available yet for this article.
September 15, 2016: Nature
https://www.readbyqxmd.com/read/27611881/effects-of-graded-levels-of-liquid-brewer-s-yeast-on-chemical-composition-and-fermentation-quality-in-cassava-pulp-and-rice-straw-based-total-mixed-ration-silage
#11
Sukanya Kamphayae, Hajime Kumagai, Smerjai Bureenok, Ramphrai Narmseelee, Patima Butcha
This study aimed to evaluate the effect of liquid brewer's yeast (LBY) addition on chemical composition and fermentation quality of mixture of LBY and cassava pulp (CVP) with rice straw (RS) in different ratios during preservation periods. Four mixtures of LBY, CVP and RS were made, that is mixture ratio of LBY : CVP : RS of 0% LBY, 20% LBY, 35% LBY and 50% LBY were 0:70:30, 20:50:30, 35:35:30 and 50:20:30 as fresh matter, respectively. The bags were opened at weeks 0, 1, 2, 4 and 8 after storage. The contents of dry matter, organic matter, crude protein (CP), ether extract (EE), neutral detergent fiber and acid detergent fiber ranged 36...
September 9, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/27603923/impact-of-in-vitro-gastrointestinal-digestion-and-transepithelial-transport-on-antioxidant-and-ace-inhibitory-activities-of-brewer-s-spent-yeast-autolysate
#12
Elsa F Vieira, José das Neves, Rui Vitorino, Diana Dias da Silva, Helena Carmo, Isabel M P L V O Ferreira
Brewer's spent yeast (BSY) autolysates may have potential applications as food ingredients or nutraceuticals due to their antioxidant and ACE-inhibitory activities. The impact of simulated gastrointestinal (GI) digestion, the interaction with intracellular sources of oxidative stress, the intestinal cell permeability of BSY peptides, and the antioxidant and ACE-inhibitory activities of BSY permeates were assayed. Gastrointestinal digestion of BSY autolysates enhanced antioxidant and ACE-inhibitory activities as measured in vitro...
October 5, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27602264/vegemite-beer-yeast-extract-spreads-as-nutrient-supplements-to-promote-fermentation
#13
Edward D Kerr, Benjamin L Schulz
Vegemite is an iconic Australian food spread made from spent brewers' yeast extract, which has been reported to be used as an ingredient in illegal home brewing. In this study, we tested the utility of Vegemite and the similar spread Marmite in promoting fermentation. We could not culture microorganisms from either Vegemite or Marmite, consistent with these food-grade spreads being essentially sterile. To test if the addition of Vegemite or Marmite could assist in fermentation when additional viable yeast was also present, solutions containing glucose and a range of concentrations of either Vegemite or Marmite were inoculated with brewers' yeast...
2016: PeerJ
https://www.readbyqxmd.com/read/27555750/flurbiprofen-antioxidant-mutual-prodrugs-as-safer-nonsteroidal-anti-inflammatory-drugs-synthesis-pharmacological-investigation-and-computational-molecular-modeling
#14
Zaman Ashraf, Alamgeer, Munazza Kanwal, Mubashir Hassan, Sahar Abdullah, Mamuna Waheed, Haseeb Ahsan, Song Ja Kim
Flurbiprofen-antioxidant mutual prodrugs were synthesized to reduce the gastrointestinal (GI) effects associated with flurbiprofen. For reducing the GI toxicity, the free carboxylic group (-COOH) was temporarily masked by esterification with phenolic -OH of natural antioxidants vanillin, thymol, umbelliferone, and sesamol. The in vitro hydrolysis of synthesized prodrugs showed that they were stable in buffer solution at pH 1.2, indicating their stability in the stomach. The synthesized prodrugs undergo significant hydrolysis in 80% human plasma and thus release free flurbiprofen...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27505907/anti-inflammatory-analgesic-and-antipyretic-activities-of-the-aqueous-methanolic-extract-of-berberis-calliobotrys-in-albino-mice
#15
Alamgeer, Huma Naz, Shadid Rasool, Sayed Atif Raza, Taseer Ahmad, Haseeb Ahsan, Muhammad Naveed Mushtaq, Hira Asif, Zahid Khan, Nabeela Noor, Ambreen Malik Utra, Umme-Habiba-Hassan
The aqueous methanolic extract of stem part of Berberis calliobotiys (AMEBC) was evaluated for anti-inflammatory, analgesic and antipyretic activities in albino mice. Anti-inflammatory activity was evaluated by using carrageenan and albumin induced paw edema, while the analgesic effect was assessed by using formalin-induced paw licking and acetic acid induced abdominal writhing in mice. The brewer's yeast-induced pyrexia model was used for antipyretic investigation. Ibuprofen (40 mg/kg) was used as a standard drug in all the three models...
May 2016: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/27495801/pharmacological-screening-of-monotheca-buxifolia-falc-a-dc-for-antinociceptive-anti-inflammatory-and-antipyretic-activities
#16
Irfan Ullah, Jamshaid Ali Khan, Muhammad Shahid, Ajmal Khan, Achyut Adhikari, Peer Abdul Hannan, Ibrahim Javed, Faisal Shakeel, Umar Farooq
BACKGROUND: Medicinal plants have proven their importance as a valuable source of molecules with therapeutic potential. Monotheca buxifolia (Falc.) A. DC. (family: Sapotaceae) is traditionally used as a hematinic, laxative, digestive, anthelmintic, antipyretic, and in the treatment of gastro-urinary disorders. To provide scientific evidence for its folkloric use, the present study investigated Monotheca buxifolia fruit hydro-ethanolic extract (MBHE) for its prospective antinociceptive, anti-inflammatory and antipyretic activities...
August 5, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27493240/rearing-larvae-of-the-avian-nest-parasite-philornis-downsi-diptera-muscidae-on-chicken-blood-based-diets
#17
Paola F Lahuatte, M P Lincango, G E Heimpel, C E Causton
Captive rearing of insect pests is necessary to understand their biology and to develop control methods. The avian nest fly, Philornis downsi Dodge and Aitken, is a blood-sucking parasite during its larval stage and a serious threat to endemic birds in the Galapagos Islands where it is considered invasive. In order to procure large numbers of flies for biological studies, rearing media and diets were trialed for rearing the larval stage of P. downsi under controlled conditions in the absence of its avian host...
2016: Journal of Insect Science
https://www.readbyqxmd.com/read/27471059/degradation-of-spent-craft-brewer-s-yeast-by-caprine-rumen-hyper-ammonia-producing-bacteria
#18
B E Harlow, R W Bryant, S D Cohen, S P O'Connell, M D Flythe
UNLABELLED: Spent yeast from craft beers often includes more hops (Humulus lupulus L.) secondary metabolites than traditional recipes. These compounds include α- and β- acids, which are antimicrobial to the rumen hyper ammonia-producing bacteria (HAB) that are major contributors to amino acid degradation. The objective was to determine if the hops acids in spent craft brewer's yeast (CY; ~ 3·5 mg g(-1) hops acids) would protect it from degradation by caprine rumen bacteria and HAB when compared to a baker's yeast (BY; no hops acids)...
October 2016: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/27449518/rdna-copy-number-variants-are-frequent-passenger-mutations-in-saccharomyces-cerevisiae-deletion-collections-and-de-novo-transformants
#19
Elizabeth X Kwan, Xiaobin S Wang, Haley M Amemiya, Bonita J Brewer, M K Raghuraman
The Saccharomyces cerevisiae ribosomal DNA (rDNA) locus is known to exhibit greater instability relative to the rest of the genome. However, wild-type cells preferentially maintain a stable number of rDNA copies, suggesting underlying genetic control of the size of this locus. We performed a screen of a subset of the Yeast Knock-Out (YKO) single gene deletion collection to identify genetic regulators of this locus and to determine if rDNA copy number correlates with yeast replicative lifespan. While we found no correlation between replicative lifespan and rDNA size, we identified 64 candidate strains with significant rDNA copy number differences...
September 8, 2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27449232/spent-brewer-s-yeast-extract-as-an-ingredient-in-cooked-hams
#20
Gaston Pancrazio, Sara C Cunha, Paula Guedes de Pinho, Mónica Loureiro, Sónia Meireles, Isabel M P L V O Ferreira, Olívia Pinho
This work describes the effect of the incorporation of 1% spent yeast extract into cooked hams. Physical/chemical/sensorial characteristics and changes during 12 and 90days storage were evaluated on control and treated cooked hams processed for 1.5, 2.0, 2.5 or 3h. Spent yeast extract addition increased hardness, chewiness, ash, protein and free amino acid content. Similar volatile profiles were obtained, although there were some quantitative differences. No advantages were observed for increased cooking time...
November 2016: Meat Science
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