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https://www.readbyqxmd.com/read/29444188/switching-and-loss-of-cellular-cytokine-producing-capacity-characterize-in-vivo-viral-infection-and-malignant-transformation-in-human-t-lymphotropic-virus-type-1-infection
#1
Huseini Kagdi, Maria Antonietta Demontis, Juan Carlos Ramos, Graham P Taylor
Adult T-cell leukaemia/lymphoma (ATL) arises from chronic non-malignant human T lymphotropic virus type-1 (HTLV-1) infection which is characterized by high plasma pro-inflammatory cytokines whereas ATL is characterized by high plasma anti-inflammatory (IL-10) concentrations. The poor prognosis of ATL is partly ascribed to disease-associated immune suppression. ATL cells have a CD4+CCR4+CD26-CD7- immunophenotype but infected cells with this immunophenotype ('ATL-like' cells) are also present in non-malignant HTLV-1 infection...
February 14, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29444138/voxel-level-quantification-of-11c-curb-a-radioligand-for-fatty-acid-amide-hydrolase-using-high-resolution-positron-emission-tomography
#2
Pablo M Rusjan, Dunja Knezevic, Isabelle Boileau, Junchao Tong, Romina Mizrahi, Alan A Wilson, Sylvain Houle
[11C]CURB is a novel irreversible radioligand for imaging fatty acid amide hydrolase in the human brain. In the present work, we validate an algorithm for generating parametric map images of [11C]CURB acquired with a high resolution research tomograph (HRRT) scanner. This algorithm applies the basis function method on an irreversible two-tissue compartment model (k4 = 0) with arterial input function, i.e., BAFPIC. Monte Carlo simulations are employed to assess bias and variability of the binding macroparameters (Ki and λk3) as a function of the voxel noise level and the range of basis functions...
2018: PloS One
https://www.readbyqxmd.com/read/29443942/understanding-the-effect-of-particle-size-and-processing-on-almond-lipid-bioaccessibility-through-microstructural-analysis-from-mastication-to-faecal-collection
#3
Giuseppina Mandalari, Mary L Parker, Myriam M-L Grundy, Terri Grassby, Antonella Smeriglio, Carlo Bisignano, Roberto Raciti, Domenico Trombetta, David J Baer, Peter J Wilde
We have previously reported on the low lipid bioaccessibility from almond seeds during digestion in the upper gastrointestinal tract (GIT). In the present study, we quantified the lipid released during artificial mastication from four almond meals: natural raw almonds (NA), roasted almonds (RA), roasted diced almonds (DA) and almond butter from roasted almonds (AB). Lipid release after mastication (8.9% from NA, 11.8% from RA, 12.4% from DA and 6.2% from AB) was used to validate our theoretical mathematical model of lipid bioaccessibility...
February 14, 2018: Nutrients
https://www.readbyqxmd.com/read/29443929/claimed-effects-outcome-variables-and-methods-of-measurement-for-health-claims-on-foods-related-to-vision-proposed-under-regulation-ec-1924-2006
#4
Daniela Martini, Augusto Innocenti, Chiara Cosentino, Giorgio Bedogni, Donato Angelino, Beatrice Biasini, Ivana Zavaroni, Marco Ventura, Daniela Galli, Prisco Mirandola, Marco Vitale, Alessandra Dei Cas, Riccardo C Bonadonna, Giovanni Passeri, Carlo Pruneti, Daniele Del Rio
Adequate visual function has a strong impact on the quality of life of people. Several foods and food components have been hypothesized to play a role in the maintenance of normal visual function and in the prevention of eye diseases. Some of these foods/food components have been the object of a request of authorization for use of health claims under Articles 13(5) or 14 of the Regulation (EC) 1924/2006. Most of these requests have received a negative opinion from the European Food Safety Authority (EFSA) due to the choice of inappropriate outcome variables (OVs) and/or methods of measurement (MMs) applied in the studies used to substantiate the claims...
February 14, 2018: Nutrients
https://www.readbyqxmd.com/read/29443801/reply
#5
Carlos A Medina, Angelica G Ortiz, Nidhi Relhan, William E Smiddy, Justin H Townsend, Harry W Flynn
No abstract text is available yet for this article.
February 13, 2018: Retina
https://www.readbyqxmd.com/read/29443532/aggregate-formation-of-surface-modified-nanoparticles-in-solvents-and-polymer-nanocomposites
#6
Dafne Musino, Anne-Caroline Genix, Thomas Chaussée, Laurent Guy, Natalia Meissner, Radosław Kozak, Thomas Bizien, Julian Oberdisse
A new method based on the combination of small-angle scattering, reverse Monte Carlo simulations, and an aggregate recognition algorithm is proposed to characterize the structure of nanoparticle suspensions in solvents and polymer nanocomposites, allowing detailed studies of the impact of different nanoparticle surface modifications. Experimental small-angle scattering is reproduced using simulated annealing of configurations of polydisperse particles in a simulation box compatible with the lowest experimental q-vector...
February 14, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29442821/supramolecular-arrangement-of-iron-phthalocyanine-in-langmuir-schaefer-and-electrodeposited-thin-films
#7
Cibely S Martin, Priscila Alessio, Frank N Crespilho, Carlos J L Constantino
The supramolecular arrangement in thin film technology has been explored through different deposition techniques aiming to control the film properties at the molecular level. We report on the formation of iron phthalocyanine (FePc) films using both Langmuir-Schaefer (LS) and electrodeposition methods. The multilayer formation was monitored with ultraviolet-visible absorption spectroscopy (UV-vis) and electrochemical measurements. According to Raman spectroscopy, atomic force microscopy (AFM), and scanning electron microscopy (SEM), the surface morphology of electrodeposited films is more homogeneous than LS films at micro and nanometer scales...
May 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442756/extraction-of-dysprosium-ions-with-dtpa-functionalized-superparamagnetic-nanoparticles-probed-by-energy-dispersive-x-ray-fluorescence-and-tem-high-angle-annular-dark-field-imaging
#8
Fernando Menegatti de Melo, Sabrina da Nobrega Almeida, Noemi Saori Uezu, Carlos Alberto Ospina Ramirez, Antonio Domingues Dos Santos, Henrique Eisi Toma
The extraction of dysprosium (Dy3+) ions from aqueous solution was carried out successfully, using magnetite (Fe3O4) nanoparticles functionalized with diethylenetriaminepentaacetic acid (MagNP@DTPA). The process was monitored by energy dispersive X-ray fluorescence spectroscopy, as a function of concentration, proceeding according to a Langmuir isotherm with an equilibrium constant of 2.57 × 10-3 g(MagNP) L-1 and a saturation limit of 63.2 mgDy/gMagNP. The presence of paramagnetic Dy3+ ions attached to the superparamagnetic nanoparticles led to an overall decrease of magnetization...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442726/poly-allylamine-hydrochloride-pah-and-bovine-serum-albumin-bsa-protein-nanostructured-as-layer-by-layer-thin-films
#9
Antonio Wellington Lima de Sa, Hugo Gajardoni de Lemos, Marcelo A Pereira-da-Silva, Everaldo Carlos Venancio
In this work it was studied the production of nanostructured thin films containing alternating layers of poly(allylamine hydrochloride) (PAH) and bovine serum albumin protein (BSA). It was studied the adsorption processes of these materials onto solid surfaces, which included adsorption kinetics and film growth studies by using UV-Vis spectroscopy. The film morphology, thickness and roughness were studied by using atomic force microscopy (AFM). The AFM results showed that the film presented a globular-like surface morphology and a thickness within the nanoscale, which could be controlled by the number of deposited layers...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442553/phase-reorganization-leads-to-transient-%C3%AE-lfp-spatial-wave-patterns-in-motor-cortex-during-steady-state-movement-preparation
#10
Michael Everett Rule, Carlos E Vargas-Irwin, John P Donoghue, Wilson Truccolo
Previous studies on the origin and properties of spatial patterns in motor cortex beta local field potential (β-LFP) oscillations have focused on planar traveling waves. However, it is unclear (a) whether β-LFP waves are limited to plane waves, or even (b) whether they are propagating waves of excito-excitatory activity, i.e. primarily traveling waves in excitable media; they could reflect, instead, reorganization in the relative phases of transient oscillations at different spatial sites. We addressed these two problems in β-LFPs recorded via microelectrode arrays implanted in three adjacent motor-cortex areas of non-human primates during steady-state movement preparation...
February 14, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29442489/helicobacter-pylori-what-are-the-challenges-of-today-and-in-the-years-to-come
#11
Rinaldo Pellicano, Carlo A Fallone
No abstract text is available yet for this article.
February 14, 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29442402/ectopic-pregnancy-in-women-with-recurrent-miscarriage
#12
Carlo Ticconi, Maria V Capogna, Federica Martelli, Barbara Borelli, Valentina Bruno, Raffaella Ergasti, Roberto Sorge, Emilio Piccione, Adalgisa Pietropolli
AIM: The aim of this study was to investigate the possible association between recurrent miscarriage (RM) and ectopic pregnancy (EP). METHODS: In this case-control retrospective study, the clinical cards of women followed as outpatients in the RM and low-risk pregnancy offices of the Obstetrics and Gynecology Unit at the Policlinico Tor Vergata University Hospital were carefully reviewed for the occurrence of EP. RESULTS: Overall, 598 women with RM and 2043 normal women without RM (controls) were included in the study...
February 14, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29442393/mineral-trioxide-aggregate-enriched-with-iron-disulfide-nanostructures-an-evaluation-of-their-physical-and-biological-properties
#13
Liliana Argueta-Figueroa, José J Delgado-García, René García-Contreras, Omar Martínez-Alvarez, José Santos-Cruz, Carlos Oliva-Martínez, Laura S Acosta-Torres, Javier de la Fuente-Hernández, Ma C Arenas-Arrocena
The purpose of this study was to characterize mineral trioxide aggregates (MTA) enriched with iron disulfide (FeS2) nanostructures at different concentrations, and to investigate their storage modulus, radiopacity, setting time, pH, cytotoxicity, and antimicrobial activity. Iron disulfide nanostructures [with particle size of 0.357 ± 0.156 μm (mean ± SD)] at weight ratios of 0.2, 0.4, 0.6, 0.8, and 1.0 wt% were added to white MTA (wMTA). The radiopacity, rheological properties, setting time, and pH, as well as the cytotoxicity (assessed using the MTT assay) and antibacterial activity (assessed using the broth microdilution test) were determined for MTA/FeS2nanostructures...
February 14, 2018: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/29442313/impact-of-oxytetracycline-and-bacterial-bioaugmentation-on-the-efficiency-and-microbial-community-structure-of-a-pesticide-degrading-biomixture
#14
Víctor Castro-Gutiérrez, Mario Masís-Mora, Elizabeth Carazo-Rojas, Marielos Mora-López, Carlos E Rodríguez-Rodríguez
An experimental study evaluating the effect of bioaugmentation and antibiotic (oxytetracycline) application on pesticide degradation and microbial community structure of a biomixture used in a biopurification system (BPR) was conducted. The bioaugmentation employed a carbofuran-degrading bacterial consortium. The non-bioaugmented biomixture showed excellent performance for removal of atrazine (t1/2: 9.9 days), carbendazim (t1/2: 3.0 days), carbofuran (t1/2: 2.8 days), and metalaxyl (t1/2: 2.7 days). Neither the addition of oxytetracycline nor bioaugmentation affected the efficiency of pesticide removal or microbial community (bacterial and fungal) structure, as determined by DGGE analysis...
February 14, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29442300/population-screening-for-hereditary-haemochromatosis-in-australia-construction-and-validation-of-a-state-transition-cost-effectiveness-model
#15
Barbara de Graaff, Lei Si, Amanda L Neil, Kwang Chien Yee, Kristy Sanderson, Lyle C Gurrin, Andrew J Palmer
INTRODUCTION: HFE-associated haemochromatosis, the most common monogenic disorder amongst populations of northern European ancestry, is characterised by iron overload. Excess iron is stored in parenchymal tissues, leading to morbidity and mortality. Population screening programmes are likely to improve early diagnosis, thereby decreasing associated disease. Our aim was to develop and validate a health economics model of screening using utilities and costs from a haemochromatosis cohort...
March 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29442242/fuse-certification-enhances-performance-on-a-virtual-computer-based-simulator-for-dispersive-electrode-placement
#16
Michael Dombek, Carlos A Lopez, Zhongqing Han, Alyssa Lungarini, Nicole Santos, Steven Schwaitzberg, Caroline Cao, Daniel B Jones, Suvranu De, Jaisa Olasky
BACKGROUND: The Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) has developed the fundamental use of surgical energy (FUSE) didactic curriculum in order to further understanding of the safe use of surgical energy. The virtual electrosurgical skill trainer (VEST) is being developed as a complementary simulation-based curriculum, with several modules already existing. Subsequently, a new VEST module has been developed about dispersive electrode placement. The purpose of this study is to assess knowledge about dispersive electrode placement in surgeons and surgical trainees in addition to describing a new VEST module...
February 13, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29442226/molecular-evolution-and-phylodynamics-of-hepatitis-b-virus-infection-circulating-in-iran
#17
Sayed-Hamidreza Mozhgani, Seyed Amir Malekpour, Mehdi Norouzi, Fatemeh Ramezani, Seyed Abdolrahim Rezaee, Vahdat Poortahmasebi, Mehdi Sadeghi, Seyed Moayed Alavian, Mohadeseh Zarei-Ghobadi, Azam Ghaziasadi, Hadi Karimzadeh, Reza Malekzadeh, Masood Ziaee, Farshid Abedi, Behrooz Ataei, Majid Yaran, Babak Sayad, Hamid Reza Jahantigh, Mohammad Hossein Somi, Gholamreza Sarizadeh, Ismail Sanei-Moghaddam, Fariborz Mansour-Ghanaei, Hossein Keyvani, Ebrahim Kalantari, Zahra Fakhari, Babak Geravand, Seyed Mohammad Jazayeri
Previous local and national Iranian publications indicate that all Iranian hepatitis B virus (HBV) strains belong to HBV genotype D. The aim of this study was to analyze the evolutionary history of HBV infection in Iran for the first time, based on an intensive phylodynamic study. The evolutionary parameters, time to most recent common ancestor (tMRCA), and the population dynamics of infections were investigated using the Bayesian Monte Carlo Markov chain (BMCMC). The effective sample size (ESS) and sampling convergence were then monitored...
February 13, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29442160/peri-articular-injection-of-an-analgesic-mixture-in-primary-total-hip-arthroplasty-an-effective-strategy-for-pain-control-during-the-first-post-operative-day
#18
Maria Bautista, Meilyn Muskus, Adolfo Llinás, Guillermo Bonilla, Carlos Guerrero, Jairo Moyano
BACKGROUND: Previous studies of soft tissue infiltration in hip arthroplasty present variable results. The purpose of this study is to identify whether injection of an analgesic mixture improves pain management during the immediate post-operative period. MATERIALS AND METHODS: This cohort study compared 129 patients that received peri-articular soft tissue injection with 20 ml of 0.25% bupivacaine and 2 ml of ketorolac (30 mg/1 ml) in 28 ml of saline solution, with 71 patients who did not received injections...
February 13, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29441810/pon2-and-pparg-polymorphisms-as-biomarkers-of-risk-for-coronary-heart-disease
#19
Thelma Beatriz González-Castro, Carlos Alfonso Tovilla-Zárate, Isela Esther Juárez-Rojop, Yazmín Hernández-Díaz, María Lilia López-Narváez, Candelario Rodríguez-Pérez, Yahaira Karina González-Hernández, Miguel Ángel Ramos-Méndez
AIM: Investigate the correlation between paraoxonase 2 (PON2) Ser311Cys polymorphism as well as the peroxisome proliferator-activated receptor gamma (PPARG) His477His polymorphism and the susceptibility to development of coronary heart diseases (CHD) through a meta-analysis. METHODS: Odds ratio and the corresponding 95% CI were used to assess the results. We included 7476 CHD patients and 8504 healthy controls. All the statistical analyses were performed by Comprehensive Meta-Analysis software (CMA, version 2...
February 14, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29441571/arterial-and-microvascular-supply-of-cerebral-hemispheres-in-the-nude-mouse-revealed-using-corrosion-casting-and-scanning-electron-microscopy
#20
Simone Sangiorgi, Alessandro De Benedictis, Marcella Reguzzoni, Andrea Trezza, Silvia Cossu, Carlo Efisio Marras, Silvio Bellocchi, Alessandro Manelli, Marina Protasoni
Morphological analyses of cerebral vascularization are not only important for the characterization of the anatomical and physiological relationships between vascular and nervous tissue, but also required to understand structural modifications that occur in many pathological conditions affecting the brain. The aim of this study was to generate a three-dimensional vascular map of the cerebral hemispheres in the nude mouse brain, a widely used animal model for studying tumour biology. We used the corrosion casting (CC) technique to isolate blood vessels from 30 nude mouse brains...
February 14, 2018: Journal of Anatomy
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