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https://www.readbyqxmd.com/read/29040746/characterization-of-an-in-house-developed-multi-cylindrical-moderator-neutron-spectrometer
#1
T Liamsuwan, J Channuie, S Wonglee, M Kowatari, S Nishino
This article describes the characterization of an in-house developed multi-cylindrical moderator neutron spectrometer, which consists of a cylindrical 3He proportional counter and cylindrical moderator shells of different sizes. The response matrix of the spectrometer was calculated by Monte Carlo simulations for neutron energies from 1 × 10-8 to 10 MeV and verified with measurements in 0.144 MeV, 1.2 MeV and 241AmBe neutron standard fields. Influence of scattered neutrons was properly eliminated from the measured response using the shadow cone technique...
October 13, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29040734/geometrical-efficiency-of-plane-parallel-ionization-chambers-in-proton-scanning-beam
#2
N Mojzeszek, M Klodowska, W Komenda, L Stolarczyk, R Kopec, P Olko
For commissioning of a proton therapy unit depth dose distributions must be determined and introduced into the Treatment Planning System. In pencil beam scanning (PBS) technique, integral depth dose (IDD) acquisition should be performed with detector large enough to ensure entire beam laterally broadened by scattered and secondary contributions. The purpose of this article is to quantify, using measurements and Monte Carlo transport calculations, the ionization chamber's (IC) geometrical efficiency versus the chamber radius and proton beam energy...
October 11, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29040727/whole-genome-sequencing-of-african-dogs-provides-insights-into-adaptations-against-tropical-parasites
#3
Yan-Hu Liu, Lu Wang, Tao Xu, Xiaomin Guo, Yang Li, Ting-Ting Yin, He-Chuan Yang, Hu Yang, Adeniyi C Adeola, Oscar J Sanke, Newton O Otecko, Meng Wang, Yaping Ma, Olaogun S Charles, Mikkel-Holger S Sinding, Shyam Gopalakrishnan, José Alfredo Samaniego, Anders J Hansen, Carlos Fernandes, Philippe Gaubert, Jane Budd, Philip M Dawuda, Eli Knispel Rueness, Lubin Jiang, Weiwei Zhai, M T P Gilbert, Min-Sheng Peng, Xiaopeng Qi, Guo-Dong Wang, Ya-Ping Zhang
Natural selection in domestic dogs is of great interest in evolutionary biology since dogs have migrated to every inhabited continent of the world alongside humans, and adapted to diverse environments. Here, we explored their demographic history and genetic basis of adaptation to the tropical African environment using whole genome analyses of 19 African indigenous dogs from Nigeria. Demographic analysis suggests that the ancestors of these dogs migrated into Africa from Eurasia 14,000 years ago and underwent a severe founder effect before population expansion...
October 10, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29040724/additional-characterisation-of-the-thermal-neutron-pile-at-the-national-physical-laboratory-uk
#4
N P Hawkes, P Kolkowski, N J Roberts, P Salvador-Castiñeira, G C Taylor, D J Thomas
As part of its wide-ranging neutron metrology capabilities, the National Physical Laboratory in the UK has a thermal neutron facility in which accelerator-produced neutrons are moderated within a large assembly or pile of graphite bricks. The neutron field has previously been well characterised in terms of the fluence rate and energy spectrum at various irradiation positions. However, recent changes to the structure (e.g. enlarging the central irradiation cavity) have prompted a renewal and extension of this work...
October 13, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29040720/genome-wide-prediction-of-minor-groove-electrostatic-potential-enables-biophysical-modeling-of-protein-dna-binding
#5
Tsu-Pei Chiu, Satyanarayan Rao, Richard S Mann, Barry Honig, Remo Rohs
Protein-DNA binding is a fundamental component of gene regulatory processes, but it is still not completely understood how proteins recognize their target sites in the genome. Besides hydrogen bonding in the major groove (base readout), proteins recognize minor-groove geometry using positively charged amino acids (shape readout). The underlying mechanism of DNA shape readout involves the correlation between minor-groove width and electrostatic potential (EP). To probe this biophysical effect directly, rather than using minor-groove width as an indirect measure for shape readout, we developed a methodology, DNAphi, for predicting EP in the minor groove and confirmed the direct role of EP in protein-DNA binding using massive sequencing data...
October 11, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29040679/2-fluoroarabinonucleic-acid-modification-traps-g-quadruplex-and-i-motif-structures-in-human-telomeric-dna
#6
Hala Abou Assi, Roberto El-Khoury, Carlos González, Masad J Damha
No abstract text is available yet for this article.
October 11, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29040678/extended-models-for-nosocomial-infection-parameter-estimation-and-model-selection
#7
Alun Thomas, Karim Khader, Andrew Redd, Molly Leecaster, Yue Zhang, Makoto Jones, Tom Greene, Matthew Samore
We consider extensions to previous models for patient level nosocomial infection in several ways, provide a specification of the likelihoods for these new models, specify new update steps required for stochastic integration, and provide programs that implement these methods to obtain parameter estimates and model choice statistics. Previous susceptible-infected models are extended to allow for a latent period between initial exposure to the pathogen and the patient becoming themselves infectious, and the possibility of decolonization...
October 12, 2017: Mathematical Medicine and Biology: a Journal of the IMA
https://www.readbyqxmd.com/read/29040557/divergence-and-convergence-in-cause-specific-premature-adult-mortality-in-mexico-and-us-mexican-hispanics-from-1995-to-2015-analyses-of-4-9-million-individual-deaths
#8
Luz Myriam Reynales-Shigematsu, Carlos Manuel Guerrero-López, Mauricio Hernández Ávila, Hyacinth Irving, Prabhat Jha
Background: Mexicans and US Mexican Hispanics share modifiable determinants of premature mortality. We compared trends in mortality at ages 30-69 in Mexico and among US Mexican Hispanics from 1995 to 2015. Methods: We examined nationally representative statistics on 4.2 million Mexican and 0.7 million US deaths to examine cause-specific mortality. We used lung cancer indexed methods to estimate smoking-attributable deaths stratified by high and lower burden Mexican states...
September 23, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29040448/male-brown-fat-specific-double-knockout-of-igfir-ir-atrophy-mitochondrial-fission-failure-impaired-thermogenesis-and-obesity
#9
Vanesa Viana-Huete, Carlos Guillén, Gema García, Silvia Fernández, Ana García-Aguilar, C R Kahn, Manuel Benito
It is unknown how the lack of IR (insulin receptor)/ IGFIR (insulin like growth factor receptor) in a tissue-specific manner does affect brown fat development and mitochondrial integrity and function and its impact on the redistribution of the adipose organ and the metabolic status. To address this important issue, we have developed the IR/IGFIR double knockout in brown adipose tissue-specific manner (DKO). Lack of those receptors caused a severe brown fat atrophy, an enhanced beige cell clusters in inguinal fat, loss of mitochondrial mass, mitochondrial damage related to cristae disruption, and the loss of proteins involved in autophagosome formation, mitophagy, mitochondrial quality control and dynamics and thermogenesis...
October 10, 2017: Endocrinology
https://www.readbyqxmd.com/read/29040390/robust-and-sparse-correlation-matrix-estimation-for-the-analysis-of-high-dimensional-genomics-data
#10
Angela Serra, Pietro Coretto, Michele Fratello, Roberto Tagliaferri
Motivation: Microarray technology can be used to study the expression of thousands of genes across a number of different experimental conditions, usually hundreds. The underlying principle is that genes sharing similar expression patterns, across different samples, can be part of the same co-expression system, or they may share the same biological functions. Groups of genes are usually identified based on cluster analysis. Clustering methods rely on the similarity matrix between genes...
October 12, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29040384/selansi-a-toolbox-for-simulation-of-stochastic-gene-regulatory-networks
#11
Manuel Pájaro, Irene Otero-Muras, Carlos Vázquez, Antonio A Alonso
Motivation: Gene regulation is inherently stochastic. In many applications concerning Systems and Synthetic Biology such as the reverse engineering and the de novo design of genetic circuits, stochastic effects (yet potentially crucial) are often neglected due to the high computational cost of stochastic simulations. With advances in these fields there is an increasing need of tools providing accurate approximations of the stochastic dynamics of gene regulatory networks (GRNs) with reduced computational effort...
October 11, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29040372/response-to-commentary-on-gluteal-augmentation-techniques-a-comprehensive-literature-review
#12
Carlo M Orangs, Mathias Tremp, Martin Haug, Daniel F Kalbermatten, Dirk J Schaefer
No abstract text is available yet for this article.
September 23, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29040340/measuring-local-depletion-of-terrestrial-game-vertebrates-by-central-place-hunters-in-rural-amazonia
#13
Mark I Abrahams, Carlos A Peres, Hugo C M Costa
The degree to which terrestrial vertebrate populations are depleted in tropical forests occupied by human communities has been the subject of an intense polarising debate that has important conservation implications. Conservation ecologists and practitioners are divided over the extent to which community-based subsistence offtake is compatible with ecologically functional populations of tropical forest game species. To quantify depletion envelopes of forest vertebrates around human communities, we deployed a total of 383 camera trap stations and 78 quantitative interviews to survey the peri-community areas controlled by 60 semi-subsistence communities over a combined area of over 3...
2017: PloS One
https://www.readbyqxmd.com/read/29040272/woody-lianas-increase-in-dominance-and-maintain-compositional-integrity-across-an-amazonian-dam-induced-fragmented-landscape
#14
Isabel L Jones, Carlos A Peres, Maíra Benchimol, Lynsey Bunnefeld, Daisy H Dent
Tropical forest fragmentation creates insular biological communities that undergo species loss and changes in community composition over time, due to area- and edge-effects. Woody lianas thrive in degraded and secondary forests, due to their competitive advantage over trees in these habitats. Lianas compete both directly and indirectly with trees, increasing tree mortality and turnover. Despite our growing understanding of liana-tree dynamics, we lack detailed knowledge of the assemblage-level responses of lianas themselves to fragmentation, particularly in evergreen tropical forests...
2017: PloS One
https://www.readbyqxmd.com/read/29040222/neurovascular-response-during-exercise-and-mental-stress-in-anabolic-steroid-users
#15
Rafael Armani Porello, Marcelo Rodrigues Dos Santos, Francis Ribeiro de Souza, Guilherme Wesley Peixoto da Fonseca, Ana Luiza Carrari Sayegh, Tiago Franco de Oliveira, César Abreu Akiho, Maurício Yonamine, Rosa Maria Rodrigues Pereira, Carlos Eduardo Negrão, Maria-Janieire de Nazaré Nunes Alves
PURPOSE: Increased resting muscle sympathetic nerve activity (MSNA) and lower forearm blood flow (FBF) were observed in young men who use anabolic androgenic steroids (AAS). However, the response of MSNA and FBF in AAS users triggered by muscle mechanoreflex and central command has never been tested. Additionally, we evaluated the blood pressure (BP) and heart rate (HR) responses during these maneuvers. METHODS: Nineteen AAS users (AASU) aged 31±6 yr and 18 AAS nonusers (AASNU) aged 29±4 yr were recruited...
October 16, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29040193/minutes-of-the-business-meeting-of-the-american-pancreatic-association-friday-october-28-2016-boston-massachusetts
#16
Carlos Fernández-Del Castillo, Miklós Sahin-Tóth, Anirban Maitra, Ashok K Saluja, Darwin L Conwell, Margaret A Tempero, Anil K Rustgi, Vay Liang W Go
No abstract text is available yet for this article.
November 2017: Pancreas
https://www.readbyqxmd.com/read/29040086/compliance-of-brown-mussel-perna-perna-production-areas-in-the-south-of-brazil-with-the-bacteriological-criteria-of-the-shellfish-hygiene-systems-in-the-european-union-and-united-states-of-america-assessing-the-impacts-on-consumer-safety
#17
Robson Ventura de Souza, Carlos José Alexandre de Campos, Luis Hamilton Pospissil Garbossa, Walter Quadros Seiffert
Levels of faecal indicator organisms (FIOs) monitored in surface water and brown mussels collected at 28 production areas in Brazil from August 2012 to October 2013 were used to assess compliance with the bacteriological standards of the shellfish hygiene classification systems used in the European Union (EU) and USA. This classification determines the level of post-harvesting purification needed to reduce the risk of illness in consumers. The results indicate that 36% of production areas would be class A under the EU system and 75% would be 'Approved' under the US system...
October 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/29040021/flexible-sigmoidoscopy-and-ct-colonography-screening-patients-experience-with-and-factors-for-undergoing-screening-insight-from-the-proteus-colon-trial
#18
Carlo Senore, Loredana Correale, Daniele Regge, Cesare Hassan, Gabriella Iussich, Marco Silvani, Arrigo Arrigoni, Lia Morra, Nereo Segnan
Purpose To compare the acceptability of computed tomographic (CT) colonography and flexible sigmoidoscopy (FS) screening and the factors predicting CT colonographic screening participation, targeting participants in a randomized screening trial. Materials and Methods Eligible individuals aged 58 years (n = 1984) living in Turin, Italy, were randomly assigned to be invited to screening for colorectal cancer with FS or CT colonography. After individuals who had died or moved away (n = 28) were excluded, 264 of 976 (27...
October 17, 2017: Radiology
https://www.readbyqxmd.com/read/29039905/calculated-decisions-vancouver-chest-pain-rule
#19
Hyunjoo Lee, Carlos Rodriguez
No abstract text is available yet for this article.
October 9, 2017: Emergency Medicine Practice
https://www.readbyqxmd.com/read/29039904/calculated-decisions-timi-risk-score-for-ua-nstemi
#20
Hyunjoo Lee, Carlos Rodriguez
No abstract text is available yet for this article.
October 9, 2017: Emergency Medicine Practice
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