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https://www.readbyqxmd.com/read/28449471/one-year-and-long-term-mortality-in-patients-hospitalized-for-chronic-obstructive-pulmonary-disease
#1
María-Teresa García-Sanz, Juan-Carlos Cánive-Gómez, Laura Senín-Rial, Jorge Aboal-Viñas, Alejandra Barreiro-García, Eva López-Val, Francisco-Javier González-Barcala
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Identifying potentially-modifiable predictors of mortality could help optimize COPD patient management. The aim of this study is to determine long-term mortality following hospitalization due to acute exacerbations of COPD (AECOPD), as well as AECOPD mortality predictors. METHODS: We conducted a retrospective study by reviewing the medical records of all patients admitted with AECOPD in the University Hospital Complex of Santiago de Compostela in 2007 and 2008...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449415/socioeconomic-determinants-of-growth-in-a-longitudinal-study-in-nepal
#2
Delan Devakumar, Dalvir Kular, Bhim P Shrestha, Carlos Grijalva-Eternod, Rhian M Daniel, Naomi M Saville, Dharma S Manandhar, Anthony Costello, David Osrin, Jonathan C K Wells
Socioeconomic status (SES) is associated with childhood anthropometry, but little is known about how it is associated with tissue growth and body composition. To investigate this, we looked at components of SES at birth with growth in early and mid-childhood, and body composition in a longitudinal study in Nepal. The exposure variables (material assets, land ownership, and maternal education) were quantified from questionnaire data before birth. Anthropometry data at birth, 2.5 and 8.5 years, were normalized using WHO reference ranges and conditional growth calculated...
April 27, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28449411/spectroscopic-characterization-of-the-reaction-products-between-criegee-intermediate-ch2oo-and-hcl
#3
Carlos Cabezas, Yasuki Endo
Pulsed Fourier-transform microwave experiments have been performed to probe the products resulting from the reaction between HCl and the simplest Criegee intermediate, CH₂OO, where the reaction is considered to be important in atmospheric chemistry. The experimentally determined rotational parameters interpreted with the help of quantum chemical calculations support the identification of chloro-methyl hydroperoxide molecule as the primary product of this reaction.
April 27, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28449079/small-non-coding-rna-and-cancer
#4
Giulia Romano, Dario Veneziano, Mario Acunzo, Carlo M Croce
The ENCODE project has reported that at least 80% of the human genome is biologically active, yet only a small part of human DNA encodes for protein. The massive amount of RNA transcribed but not translated into protein can be classified as housekeeping RNA (such as rRNA, tRNA) and regulatory RNA (such as miRNA, piRNA, lncRNA). Small non-coding RNAs, in particular, have been the focus of many studies in the last 20 years and their fundamental role in many human diseases is currently well established. Inter alia, their role in cancer development and progression, as well as in drug resistance, is being increasingly investigated...
April 26, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28448947/traveling-from-the-hypothalamus-to-the-adipose-tissue-the-thermogenic-pathway
#5
REVIEW
Cristina Contreras, Rubén Nogueiras, Carlos Diéguez, Kamal Rahmouni, Miguel López
Brown adipose tissue (BAT) is a specialized tissue critical for non-shivering thermogenesis producing heat through mitochondrial uncoupling; whereas white adipose tissue (WAT) is responsible of energy storage in the form of triglycerides. Another type of fat has been described, the beige adipose tissue; this tissue emerges in existing WAT depots but with thermogenic ability, a phenomenon known as browning. Several peripheral signals relaying information about energy status act in the brain, particularly the hypothalamus, to regulate thermogenesis in BAT and browning of WAT...
April 15, 2017: Redox Biology
https://www.readbyqxmd.com/read/28448938/choice-modeling-of-system-wide-or-large-scale-environmental-change-in-a-developing-country-context-lessons-from-the-para%C3%A3-ba-do-sul-river
#6
James R Kahn, William F Vásquez, Carlos Eduardo de Rezende
The Rio Paraiba do Sul is a highly polluted river in south central Brazil, that is contaminated by industrial, agricultural and municipal wastes, as well as being impacted by dams, water withdrawals and deforestation in the watershed. Since only very intensive and farreaching environmental policies could result in water quality improvements, valuing the restoration of the river presents many unique challenges. We develop a choice-modeling approach to valuation of the restoration of this river, with general tightening of environmental policy as the policy, and an increase in prices as the payment vehicle...
April 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28448932/seasonal-changes-of-fructans-in-dimorphic-roots-of-ichthyothere-terminalis-spreng-blake-asteraceae-growing-in-cerrado
#7
Lorrayne Veloso de Almeida, Pedro Henrique Ferri, José Carlos Seraphin, Moemy Gomes de Moraes
Cerrado is a floristically rich savanna in Brazil, whose vegetation consists of a physiognomic mosaic, influenced by rainfall seasonality. In the dry season rainfall is substantially lower and reduces soil water supply, mainly for herbs and subshrubs. Climatic seasonal variations may well define phenological shifts and induce fluctuations of plant reserve pools. Some Cerrado native species have thickened underground organs that bear buds and store reserves, as adaptive features to enable plant survival following environmental stresses...
April 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28448919/mechanochemical-mechanism-of-integrin-clustering-modulated-by-nanoscale-ligand-spacing-and-rigidity-of-extracellular-substrates
#8
Jing Yu, Jianyong Huang, John A Jansen, Chunyang Xiong, X Frank Walboomers
Experimental findings indicate that cell function and behavior such as cell growth, division, migration and differentiation, are subtly regulated via integrin-dependent cell adhesion. Cell adhesion is influenced by nanoscale ligand spacing and rigidity of extracellular substrates, as cell adhesion drops greatly when the ligand spacing is larger than ~60nm, and cell adhesion is stronger on stiff than soft substrates. However, how nanoscale ligand spacing and substrate stiffness jointly affect integrin clustering and hence nascent cell adhesion remains to be elucidated...
April 14, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28448893/diabetes-status-modifies-the-association-between-carotid-intima-media-thickness-and-incident-heart-failure-the-atherosclerosis-risk-in-communities-study
#9
Valery S Effoe, Eric E McClendon, Carlos J Rodriguez, Lynne E Wagenknecht, Gregory W Evans, Patricia P Chang, Alain G Bertoni
AIMS: Increasing carotid intima-media thickness (CIMT) is associated with incident heart failure (HF). We investigated whether this association differs by diabetes status. METHODS: We characterized 13,590 Atherosclerosis Risk in Communities Study participants free of baseline HF into normal fasting glucose (NFG, glucose <100mg/dl), impaired fasting glucose (IFG, glucose 100-125mg/dl), and type 2 diabetes (T2D, glucose ≥126mg/dl, self-report, or use of diabetes drugs)...
April 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28448855/glassy-carbon-electrode-modified-with-7-7-8-8-tetracyanoquinodimethane-and-graphene-oxide-triggered-a-synergistic-effect-low-potential-amperometric-detection-of-reduced-glutathione
#10
Baiqing Yuan, Chunying Xu, Renchun Zhang, Donghui Lv, Sujuan Li, Daojun Zhang, Lin Liu, Carlos Fernandez
A sensitive electrochemical sensor based on the synergistic effect of 7,7,8,8-tetracyanoquinodimethane (TCNQ) and graphene oxide (GO) for low-potential amperometric detection of reduced glutathione (GSH) in pH 7.2 phosphate buffer solution (PBS) has been reported. This is the first time that the combination of GO and TCNQ have been successfully employed to construct an electrochemical sensor for the detection of glutathione. The surface of the glassy carbon electrode (GCE) was modified by a drop casting using TCNQ and GO...
April 21, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28448824/a-new-quantitative-method-to-assess-disproportionately-enlarged-subarachnoid-space-desh-in-patients-with-possible-idiopathic-normal-pressure-hydrocephalus-the-silver-index
#11
Nicola Benedetto, Carlo Gambacciani, Filippo Aquila, Davide Tiziano Di Carlo, Riccardo Morganti, Paolo Perrini
OBJECTIVES: Preoperative diagnosis of idiopathic normal-pressure hydrocephalus (iNPH) remains challenging. Recently, the presence of disproportionally enlarged subarachnoid spaces and hydrocephalus (DESH) on diagnostic images has been linked to clinical improvement after ventriculoperitoneal (VP) shunt placement. In this study we describe a new quantitative method to assess DESH on CT scans and to evaluate its prognostic value. PATIENTS AND METHODS: A multiplanar reconstruction software was used to retrospectively evaluate prospectively collected radiological data (CT scans) of 26 controls and 29 consecutive patients that underwent VP shunt placement for possible iNPH...
April 19, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28448788/production-of-biogas-from-co-digestion-of-livestock-and-agricultural-residues-a-case-study
#12
Brahim Arhoun, Cesar Gomez-Lahoz, Roberto Teofilo Abdala-Diaz, Jose Miguel Rodriguez-Maroto, Francisco Garcia-Herruzo, Carlos Vereda-Alonso
This study was undertaken to determine the possible changes in the digester yield and performance for the anaerobic co-digestion under mesophilic conditions of strawberry residues (SRs) together with pig manure (PM). The first part of this paper deals with the digestion of SR as a single substrate. For organic loading rates (OLRs) of 4.4 (g L(-1) d(-1)) or less, the experimental specific biogas and methane productions are 0.588 and 0.231 L g(-1), respectively. When higher OLRs (5.5 g L(-1) d(-1)) are used the digester fails due to acidification...
April 27, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/28448726/intravitreal-injection-of-sulfamethoxazole-and-trimethoprim-associated-with-dexamethasone-as-an-alternative-therapy-for-ocular-toxoplasmosis
#13
Carlos E Souza, Heloisa Nascimento, Acácio Lima, Cristina Muccioli, Rubens Belfort
PURPOSE: To evaluate intravitreal injections of sulfamethoxazole/trimethoprim in association with dexamethasone for treating toxoplasmic retinochoroiditis. METHODS: Thirteen patients with active, recurrent ocular focal toxoplasmic retinochoroiditis and visual acuity worse than 20/63 in the affected eye were included. Ocular toxoplasmosis was diagnosed according to the classic clinical findings. The primary end point was the change in the final best-corrected visual acuity (BCVA)...
April 27, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28448473/transcriptomic-analysis-of-calcium-remodeling-in-colorectal-cancer
#14
Enrique Pérez-Riesgo, Lucía G Gutiérrez, Daniel Ubierna, Alberto Acedo, Mary P Moyer, Lucía Núñez, Carlos Villalobos
Colorectal cancer (CRC) cells undergo the remodeling of intracellular Ca(2+) homeostasis, which contributes to cancer hallmarks such as enhanced proliferation, invasion and survival. Ca(2+) remodeling includes critical changes in store-operated Ca(2+) entry (SOCE) and Ca(2+) store content. Some changes have been investigated at the molecular level. However, since nearly 100 genes are involved in intracellular Ca(2+) transport, a comprehensive view of Ca(2+) remodeling in CRC is lacking. We have used Next Generation Sequencing (NGS) to investigate differences in expression of 77 selected gene transcripts involved in intracellular Ca(2+) transport in CRC...
April 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28448467/chemical-composition-and-biological-activities-of-mono-and-heterofloral-bee-pollen-of-different-geographical-origins
#15
Jucilene Silva Araújo, Emerson Dechechi Chambó, Maria Angélica Pereira de Carvalho Costa, Samira Maria Peixoto Cavalcante da Silva, Carlos Alfredo Lopes de Carvalho, Leticia M Estevinho
Recent research shows variations in pollen chemical constituents and, consequently, in their therapeutic properties. Mono and multifloral bee pollen extracts were investigated for antioxidant and enzyme inhibitory activity properties, phenolic compounds and fatty acid composition. Generally, Eucalyptus spp. and multifloral extracts exhibited potent inhibitory activity against α-amylase, acetylcholinesterase, tyrosinase, lipoxygenase, lipase and hyaluronidase. On the other hand, Miconia spp. demonstrated higher antihemolytic activity...
April 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28448443/the-effect-of-thermal-fluctuation-on-the-receptor-mediated-adhesion-of-a-cell-membrane-to-an-elastic-substrate
#16
Bahador Marzban, Hongyan Yuan
Mechanics of the bilayer membrane play an important role in many biological and bioengineering problems such as cell-substrate and cell-nanomaterial interactions. In this work, we study the effect of thermal fluctuation and the substrate elasticity on the cell membrane-substrate adhesion. We model the adhesion of a fluctuating membrane on an elastic substrate as a two-step reaction comprised of the out-of-plane membrane fluctuation and the receptor-ligand binding. The equilibrium closed bond ratio as a function of substrate rigidity was computed by developing a coupled Fourier space Brownian dynamics and Monte Carlo method...
April 27, 2017: Membranes
https://www.readbyqxmd.com/read/28448436/role-of-archaeal-hera-protein-in-the-biology-of-the-bacterium-thermus-thermophilus
#17
Alba Blesa, Nieves G Quintans, Ignacio Baquedano, Carlos P Mata, José R Castón, José Berenguer
Intense gene flux between prokaryotes result in high percentage of archaeal genes in the genome of the thermophilic bacteria Thermus spp. Among these archaeal genes a homolog to the Sulfolobus spp. HerA protein appears in all of the Thermus spp. strains so far sequenced (HepA). The role of HepA in Thermus thermophilus HB27 has been analyzed using deletion mutants, and its structure resolved at low resolution by electron microscopy. Recombinant HepA shows DNA-dependent ATPase activity and its structure revealed a double ring, conically-shaped hexamer with an upper diameter of 150 Å and a bottom module of 95 Å...
April 27, 2017: Genes
https://www.readbyqxmd.com/read/28448412/optimizing-contrast-media-injection-protocols-in-computed-tomography-angiography-at-different-tube-voltages-evaluation-in-a-circulation-phantom
#18
Damiano Caruso, Marwen Eid, U Joseph Schoepf, Domenico De Santis, Akos Varga-Szemes, Stefanie Mangold, Christian Canstein, Virginia W Lesslie, Stephen R Fuller, B Devon Ball, Andrea Laghi, Carlo N De Cecco
OBJECTIVES: The aim of this study was to investigate the minimum iodine delivery rate (IDR) and contrast media (CM) volume required for diagnostic contrast enhancement of 350 HU (Hounsfield units) in the ascending aorta at different kV settings. METHODS: Dynamic computed tomography acquisitions from 70 to 150 kV were performed in a circulation phantom. First, injections with IDR ranging from 0.1 to 2.0 g I/s were tested for each kV. In the second part, the IDR was held constant, whereas the CM volume was reduced from 50 to 10 mL...
April 26, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28448411/image-quality-and-radiation-exposure-comparison-of-a-double-high-pitch-acquisition-for-coronary-computed-tomography-angiography-versus-standard-retrospective-spiral-acquisition-in-patients-with-atrial-fibrillation
#19
Carlos Eduardo Elias Dos Prazeres, Tiago Augusto Magalhães, Adriano Camargo de Castro Carneiro, Roberto Caldeira Cury, Valéria de Melo Moreira, Juliana Hiromi Silva Matsumoto Bello, Carlos Eduardo Rochitte
OBJECTIVE: The aim of this study was to compare image quality and radiation dose of coronary computed tomography (CT) angiography performed with dual-source CT scanner using 2 different protocols in patients with atrial fibrillation. METHODS: Forty-seven patients with AF underwent 2 different acquisition protocols: double high-pitch (DHP) spiral acquisition and retrospective spiral acquisition. The image quality was ranked according to a qualitative score by 2 experts: 1, no evident motion; 2, minimal motion not influencing coronary artery luminal evaluation; and 3, motion with impaired luminal evaluation...
April 26, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28448240/searching-for-happiness
#20
Andrea Ferrari, Paola Gaggiotti, Matteo Silva, Laura Veneroni, Chiara Magni, Stefano Signoroni, Michela Casanova, Roberto Luksch, Monica Terenziani, Filippo Spreafico, Cristina Meazza, Carlo Alfredo Clerici, Maura Massimino
No abstract text is available yet for this article.
April 27, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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