keyword
MENU ▼
Read by QxMD icon Read
search

leptin , Obesity children

keyword
https://www.readbyqxmd.com/read/27864335/effects-of-maternal-obesity-on-placental-function-and-fetal-development
#1
Kristy R Howell, Theresa Powell
Obesity has reached epidemic proportions and pregnancies in obese mothers have increased risk for complications including gestational diabetes, hypertensive disorders, preterm birth and caesarian section. Children born to obese mothers are at increased risk of obesity and metabolic disease and are susceptible to develop neuropsychiatric and cognitive disorders. Changes in placental function not only play a critical role in the development of pregnancy complications but may also be involved in linking maternal obesity to long-term health risks in the infant...
November 18, 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27863153/the-relationship-between-breast-milk-leptin-and-adiponectin-with-child-body-composition-from-3-to-5%C3%A2-years-a-follow-up-study
#2
D M Meyer, C Brei, L Stecher, D Much, S Brunner, H Hauner
BACKGROUND: Research indicates that breast milk contains bioactive components that influence metabolism in infancy and may play a role in the prevention of obesity in early childhood. In our initial study, 147 breastfeeding mother/child pairs were followed from birth to 2 years of age to examine the relationship between breast milk leptin and total adiponectin (collected at 6 weeks and 4 months postpartum) and infant body composition. Higher breast milk total adiponectin was related to greater fat mass and weight gain in children at 1 and 2 years of age, whereas leptin showed no association...
November 10, 2016: Pediatric Obesity
https://www.readbyqxmd.com/read/27753812/ssa-04-3-leptin-adiponectin-in-cardiometabolic-disease
#3
Patricio Lopez-Jaramillo
Cardiovascular diseases (CVD) are major causes of death and illness worldwide. In recent decades an increased prevalence of CVD mortality has been reported in low-medium income countries, which has been associated with changes in life styles, deficiencies in health systems and the persistence of social inequities.The metabolic syndrome comprises a cluster of cardiometabolic risk factors, with insulin resistance and increased adiposity as its central features. Identifying individuals with metabolic syndrome is important due to its association with an increased risk of coronary heart disease and type 2 diabetes mellitus (DM2)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27720196/early-improvement-in-obstructive-sleep-apnea-and-increase-in-orexin-levels-after-bariatric-surgery-in-adolescents-and-young-adults
#4
Raouf Amin, Narong Simakajornboon, Rhonda Szczesniak, Thomas Inge
BACKGROUND: Obstructive sleep apnea (OSA) associated with obesity is known to improve after bariatric surgery, but little is known about early changes in this condition after surgery. OBJECTIVES: To study the clinical course of OSA after bariatric surgery SETTING: Children's hospital in the United States METHODS: Adolescents and young adults with obstructive sleep apnea undergoing vertical sleeve gastrectomy (n = 6) or gastric bypass (n = 1) were enrolled in this prospective study...
May 30, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27687882/reference-values-for-serum-leptin-in-healthy-non-obese-children-and-adolescents
#5
Ulrik Lausten-Thomsen, Michael Christiansen, Paula Louise Hedley, Cilius Esmann Fonvig, Theresa Stjernholm, Oluf Pedersen, Torben Hansen, Jens-Christian Holm
BACKGROUND: Adipokines are biologically active, low-molecular weight peptides, which play a major role in metabolic homeostasis in humans. Leptin has gained increasing attention in pediatrics as a biomarker for various metabolic pathologies. Yet, its usefulness is hampered by the relative lack of reference values from pediatric settings. Accordingly, this study aims to evaluate serum concentrations of leptin, soluble leptin receptor (sOB-R), and free leptin index (FLI) in healthy Danish schoolchildren aged 6-18 years and subsequently to establish reference intervals across sex and age groups...
November 2016: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/27651112/inflammation-mediates-the-association-between-visceral-adiposity-and-obstructive-sleep-apnea-in-adolescents
#6
Jordan Gaines, Alexandros N Vgontzas, Julio Fernandez-Mendoza, Susan L Calhoun, Fan He, Duanping Liao, Marjorie D Sawyer, Edward O Bixler
Only a handful of studies, primarily in clinical samples, have reported an association between obesity, inflammation, and obstructive sleep apnea (OSA) in children and adolescents. No studies, however, have examined the pathogenetic link between visceral adiposity, systemic inflammation, and incident OSA in a large general population sample using objective measures of sleep and body fat. Adolescents (n = 392; mean age 17.0 ± 2.2 yr, 54.0% male) from the Penn State Child Cohort (PSCC) underwent 9-h overnight polysomnography; a DXA scan to assess body fat distribution; and a single fasting blood draw for the assessment of plasma interleukin-6 (IL-6), IL-6 soluble receptor (IL-6 sR), tumor necrosis factor alpha (TNFα), tumor necrosis factor receptor 1A (TNFR1), C-reactive protein (CRP), leptin, and adiponectin levels via ELISA...
November 1, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27643352/ssa-04-3-leptin-adiponectin-in-cardiometabolic-disease
#7
Patricio Lopez-Jaramillo
Cardiovascular diseases (CVD) are major causes of death and illness worldwide. In recent decades an increased prevalence of CVD mortality has been reported in low-medium income countries, which has been associated with changes in life styles, deficiencies in health systems and the persistence of social inequities.The metabolic syndrome comprises a cluster of cardiometabolic risk factors, with insulin resistance and increased adiposity as its central features. Identifying individuals with metabolic syndrome is important due to its association with an increased risk of coronary heart disease and type 2 diabetes mellitus (DM2)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27604470/evidence-for-energy-conservation-during-pubertal-growth-a-10-year-longitudinal-study-earlybird-71
#8
M Mostazir, A Jeffery, J Hosking, B Metcalf, L Voss, T Wilkin
BACKGROUND: Diabetes is closely linked to obesity, and obesity rates climb during adolescence for reasons that are not clear. Energy efficiency is important to obesity, and we describe a temporary but substantial fall in absolute energy expenditure, compatible with improved energy efficiency, during the rapid growth phase of puberty. METHODS: In a longitudinal cohort study lasting 10 years, we measured voluntary energy expenditure as physical activity (PA) by accelerometry, involuntary energy expenditure as resting energy expenditure (REE) by oxygen consumption, body mass index (BMI) and body composition by dual energy X-ray absorptiometry annually on 10 occasions from 7 to 16 years in the 347 children of the EarlyBird study...
October 4, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27598978/correlation-between-adipokines-and-carotid-intima-media-thickness-in-a-group-of-obese-romanian-children-is-small-for-gestational-age-status-an-independent-factor-for-cardiovascular-risk
#9
Ramona Stroescu, Teofana Bizerea, Gabriela Doroş, Monica Marazan, Maria Lesovici, Otilia Mãrginean
Objective: To investigate the relationship between markers of adiposity and common carotid artery (CIMT) in obese children born small for gestational age (SGA) versus appropriate for gestational age (AGA), to establish cut-off values for CIMT in obese pediatric populations. Subjects and methods: A cross-sectional study was carried out over a 1-year period (Jul 2013 - June 2014). We analyzed 122 obese patients aged 4-20 (mean age 14.9 ± 2.28). Twenty-six patients were born SGA...
September 5, 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27598976/leptin-as-a-predictor-of-metabolic-syndrome-in-prepubertal-children
#10
Isabel Madeira, Maria Alice Bordallo, Nádia Cristina Rodrigues, Cecilia Carvalho, Fernanda Gazolla, Paulo Collett-Solberg, Clarice Medeiros, Ana Paula Bordallo, Marcos Borges, Claudia Monteiro, Rebeca Ribeiro
Objective: Leptin has been suggested as a potential biomarker of cardiovascular risk. This paper aims to ascertain, based on a sample of prepubertal children, which serum leptin value best suited to identify metabolic syndrome (MS). Subjects and methods: This observational, cross-sectional study recruited children from the outpatient pediatrics clinic, with the purpose of validating serum leptin level cutoffs to identify MS. All obese and overweight children who met eligibility criteria were included in the study, as was a sample of normal-weight children...
September 5, 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27587073/high-sensitivity-c-reactive-protein-and-leptin-levels-related-to-body-mass-index-changes-throughout-childhood
#11
Pilar Navarro, Olaya de Dios, Teresa Gavela-Pérez, Asha Jois, Carmen Garcés, Leandro Soriano-Guillén
OBJECTIVES: To analyze the association between high-sensitivity C-reactive protein (hs-CRP) levels and cardiovascular risk factors in healthy school children, and to evaluate whether changes in body mass index (BMI) category throughout childhood affect hs-CRP levels. STUDY DESIGN: We measured serum hs-CRP levels, lipid profile, insulin levels, and leptin levels in 683 prepubertal children and 748 adolescents. A total of 272 children participated in the study in both cohorts, prepubertal (baseline; age 6-8 years) and adolescents (follow-up; age 12-16 years)...
August 29, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27564309/methylation-of-socs3-is-inversely-associated-with-metabolic-syndrome-in-an-epigenome-wide-association-study-of-obesity
#12
Omar Ali, Diana Cerjak, Jack W Kent, Roland James, John Blangero, Melanie A Carless, Yi Zhang
Epigenetic mechanisms, including DNA methylation, mediate the interaction between gene and environment and may play an important role in the obesity epidemic. We assessed the relationship between DNA methylation and obesity in peripheral blood mononuclear cells (PBMCs) at 485,000 CpG sites across the genome in family members (8-90 y of age) using a discovery cohort (192 individuals) and a validation cohort (1,052 individuals) of Northern European ancestry. After Bonferroni-correction (Pα=0.05 = 1.31 × 10(-7)) for genome-wide significance, we identified 3 loci, cg18181703 (SOCS3), cg04502490 (ZNF771), and cg02988947 (LIMD2), where methylation status was associated with body mass index percentile (BMI%), a clinical index for obesity in children, adolescents, and adults...
August 26, 2016: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/27557428/nutritional-status-in-short-stature-children-is-related-to-both-ghrelin-and-insulin-like-growth-factor-i-concentrations
#13
Renata Stawerska, Elżbieta Czkwianianc, Joanna Smyczyńska, Maciej Hilczer, Andrzej Lewiński
OBJECTIVES: Ghrelin plays an important role in the growth processes in children, additionally, it regulates appetite. The aim of the study was to assess ghrelin and insulin-like growth factor type I (IGF-I) concentrations in children with idiopathic short stature (ISS), dependent on nutritional status. METHODS: The study group included 116 children, aged 10.6 ± 3.5 years (mean ± SD), with ISS [height below -2.0 standard deviation scores (SDS), maximal growth hormone (GH) secretion during two GH-stimulating tests - over 10 ng/ml]...
August 24, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27539885/relation-of-serum-irisin-level-with-metabolic-and-antropometric-parameters-in-obese-children
#14
Gönül Çatlı, Tuncay Küme, Hale Ünver Tuhan, Ahmet Anık, Özlem Gürsoy Çalan, Ece Böber, Ayhan Abacı
OBJECTIVE: This study aimed to investigate the relationship between serum irisin level and metabolic and anthropometric parameters in obese children. METHODS: The study included 36 obese children with a body mass index (BMI) of ≥95th percentile and 30 healthy children with a BMI ranging from the 5th to the 85th percentile. Healthy and obese children had similar age, gender and pubertal stage distribution. Anthropometric and biochemical parameters (fasting glucose, insulin, lipid profile, leptin and irisin levels) were measured...
November 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27504976/early-changes-in-adipokines-from-overweight-to-obesity-in-children-and-adolescents
#15
Rafael Machado Mantovani, Natália Pessoa Rocha, Daniel Massote Magalhães, Izabela Guimarães Barbosa, Antônio Lúcio Teixeira, Ana Cristina Simões E Silva
OBJECTIVE: Childhood obesity has been associated with metabolic syndrome and cardiovascular diseases. This study aimed to compare plasma levels of traditional metabolic markers, adipokines and soluble tumor necrosis factor receptor type 1 (sTNFR1) in overweight, obese and lean children. We also assessed the relationships of these molecules with classical metabolic risk factors. METHODS: This study included 104 children and adolescents, which were grouped as: lean (n=24), overweight (n=30), and obese subjects (n=50)...
August 7, 2016: Jornal de Pediatria
https://www.readbyqxmd.com/read/27448331/overweight-and-obesity-in-children-and-adolescents-with-down-syndrome-prevalence-determinants-consequences-and-interventions-a-literature-review
#16
REVIEW
Fabio Bertapelli, Ken Pitetti, Stamatis Agiovlasitis, Gil Guerra-Junior
BACKGROUND: Children with Down syndrome (DS) are more likely to be overweight or obese than the general population of youth without DS. AIMS: To review the prevalence of overweight and obesity and their determinants in youth with DS. The health consequences and the effectiveness of interventions were also examined. METHODS AND PROCEDURES: A search using MEDLINE, Embase, Web of Science, Scopus, CINAHL, PsycINFO, SPORTDiscus, LILACS, and COCHRANE was conducted...
October 2016: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/27388590/fetuin-a-adiposity-linked-insulin-resistance-and-responsiveness-to-an-educational-based-weight-excess-reduction-program-a-population-based-survey-in-prepubertal-schoolchildren
#17
Giuseppe Murdolo, Cristina Tortoioli, Federica Celi, Vittorio Bini, Francesco Papi, Annalisa Brozzetti, Alberto Falorni
The secreted hepatokine fetuin-A emerges as an independent predictor of type 2 diabetes in adulthood. The overall aims of this study were: (1) to investigate the associations of fetuin-A with adiposity and insulin resistance, as well as its relationship with adipokines, in prepubertal children, and, (2) to evaluate whether, in prepubertal obesity, serum fetuin-A levels may either change or predict the responsiveness to an educational-based weight excess reduction program. We studied 200 prepubertal children (boys/girls: 89/111; Tanner stage 1; age: 5-13 years), included in a cohort of 44,231 adolescents who participated in an extensive Italian school-based survey...
July 7, 2016: Endocrine
https://www.readbyqxmd.com/read/27366637/genetic-markers-of-inflammation-may-not-contribute-to-metabolic-traits-in-mexican-children
#18
Neeti Vashi, Carolina Stryjecki, Jesus Peralta-Romero, Fernando Suarez, Jaime Gomez-Zamudio, Ana I Burguete-Garcia, Miguel Cruz, David Meyre
BACKGROUND: Low-grade chronic inflammation is a common feature of obesity and its cardio-metabolic complications. However, little is known about a possible causal role of inflammation in metabolic disorders. Mexico is among the countries with the highest obesity rates in the world and the admixed Mexican population is a relevant sample due to high levels of genetic diversity. METHODS: Here, we studied 1,462 Mexican children recruited from Mexico City. Six genetic variants in five inflammation-related genes were genotyped: rs1137101 (leptin receptor (LEPR)), rs7305618 (hepatocyte nuclear factor 1 alpha (HNF1A)), rs1800629 (tumor necrosis factor alpha (TNFA)), rs1800896, rs1800871 (interleukin-10 (IL-10)), rs1862513 (resistin (RETN))...
2016: PeerJ
https://www.readbyqxmd.com/read/27358533/assessment-of-left-ventricular-mass-index-could-predict-metabolic-syndrome-in-obese-children
#19
Usama M Alkholy, Ihab A Ahmed, Nehad A Karam, Yasser Fathy Ali, Ahmed Yosry
BACKGROUND: Childhood obesity is a major risk factor for cardiovascular diseases in children and adults. OBJECTIVES: The purpose of this study was to evaluate the serum leptin level and the cardiac changes in normotensive obese children and to study the relationship between left ventricular mass index (LVMI) and serum leptin with the parameters of metabolic syndrome (MS) in obese children. METHODS: This study was conducted in al Jeddani Hospital and Ibn Sina College Hospital in Saudi Arabia in the period from July 2012 to December 2013, and included 82 obese children...
July 2016: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/27358118/headache-migraine-and-obesity-an-overview-on-plausible-links
#20
REVIEW
D Laino, G Vitaliti, P Parisi, P Pavone, A Verrotti, R Lubrano, N Matin, R Falsaperla
Headache can represent different disorders with different etiologies; including cardiac, cerebral, vascular, psychiatric, metabolic, neurologic diseases. Recent studies have highlighted that obesity is significantly associated with headache and disability in adults. This rule also applies to children. This review focuses on literature data studying any eventual relationship between headache, migraine and obesity [shown in Body Mass Index (BMI)] in children. Research data have highlighted that there is a relationship between headache physiopathology and central and peripheral mechanisms responsible for food assumption...
April 2016: Journal of Biological Regulators and Homeostatic Agents
keyword
keyword
65321
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"