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leptin , Obesity children

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https://www.readbyqxmd.com/read/29885866/leptin-osteopontin-axis-regulated-type-2t-helper-cell-response-in-allergic-rhinitis-with-obesity
#1
Qingxiang Zeng, Xi Luo, Miaomiao Han, Wenlong Liu, Huabin Li
The prevalence of allergic rhinitis (AR) and obesity in children increased concurrently during recent decades. However, the molecular pathway involved in the interaction between obesity and AR is still unclear. We aimed to investigate the interaction between leptin and osteopontin (OPN) and their effect on T helper (TH ) response in the development of AR in children. Thirty AR and 30 healthy children with or without obesity were enrolled. Serum leptin and OPN levels were measured and their relationship with TH 1/2 cytokines was analyzed...
June 6, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29885650/mother-s-obesity-and-high-child-s-waist-circumference-are-predictive-factors-of-severe-child-s-obesity-an-observational-study-in-french-guiana
#2
Falucar Njuieyon, Emma Cuadro-Alvarez, Elise Martin, Noémie Lachaume, Yajaira Mrsic, Fanny Henaff, Chimène Maniassom, Antoine Defo, Narcisse Elenga
BACKGROUND: This study aims to describe the predictive factors of severe obesity in children followed in French Guiana. METHODS: In this observational study, the patients from the French Guianese Childhood Obesity Group database were prospectively included, after giving a statement of patient's non opposition. RESULTS: Our group classifications revealed that 36 of 150 (24%) participants were classified as being metabolically abnormal obesity" (MAO), while 114 of 150 (76%) were categorized as metabolically normal obesity" (MNO)...
June 9, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29858907/impact-of-a-group-based-treatment-program-on-adipocytokines-oxidative-status-inflammatory-cytokines-and-arterial-stiffness-in-obese-children-and-adolescents
#3
Jeerunda Santiprabhob, Kawewan Limprayoon, Prapun Aanpreung, Ratiya Charoensakdi, Ruchaneekorn W Kalpravidh, Benjaluck Phonrat, Rungsunn Tungtrongchitr
BACKGROUND: Dysregulation of adipocytokines, inflammatory cytokines and oxidative stress are associated with the pathogenesis of obesity-related complications. This study aimed to evaluate the effect of a group-based lifestyle modification program on adipocytokines, inflammatory cytokines, oxidative status and arterial stiffness in obese youth. METHODS: A 1-year weight-reduction program was conducted. The program consisted of initial hospitalization and five outpatient group-based sessions held at 1, 2, 3, 6 and 9 months...
June 2, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29843129/appetite-related-eating-behaviours-an-overview-of-assessment-methods-determinants-and-effects-on-children-s-weight
#4
REVIEW
Ana Freitas, Gabriela Albuquerque, Cláudia Silva, Andreia Oliveira
Identifying the underlying child-eating behaviours that contribute to weight differences across growth has been a constant challenge. This report reviews the various literature approaches for assessing appetite regulation. In doing so, it attempts to understand how appetite control develops and determines the eating habits in early childhood, and its effects on children's weight status. The interaction between homeostatic and hedonic mechanisms largely explains the appetite regulation process. Homeostatic mechanisms are mediated by the biological need to maintain the body's energy reserves, increasing the motivation to eat...
May 29, 2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29762052/effects-of-physical-exercise-on-adiponectin-leptin-and-inflammatory-markers-in-childhood-obesity-systematic-review-and-meta-analysis
#5
Felice Sirico, Antonio Bianco, Giovanni D'Alicandro, Clotilde Castaldo, Stefania Montagnani, Rocco Spera, Franca Di Meglio, Daria Nurzynska
BACKGROUND: New findings on adipose tissue physiology and obesity-associated inflammation status suggest that modification of the adipokine level can be relevant for the long-term prevention of obesity-associated chronic disease. OBJECTIVES: The scope of the present study was to investigate the effectiveness of physical exercise in reducing the systemic inflammation related to obesity in children. METHODS: We conducted a systematic review with meta-analysis of controlled randomized trials, identified through electronic database search, which investigated the effect of physical exercise, without concomitant dietary intervention, on adiponectin, leptin, and/or other inflammatory markers in children up to age 18 years with a body mass index greater than the 95th percentile for age and sex...
May 15, 2018: Childhood Obesity
https://www.readbyqxmd.com/read/29759068/childhood-retinol-binding-protein-4-rbp4-levels-predicting-the-10-year-risk-of-insulin-resistance-and-metabolic-syndrome-the-bcams-study
#6
Ge Li, Issy C Esangbedo, Lu Xu, Junling Fu, Lujiao Li, Dan Feng, Lanwen Han, Xinhua Xiao, Mingyao Li, Jie Mi, Ming Li, Shan Gao, Steven M Willi
BACKGROUND: Elevated retinol-binding protein 4 (RBP4) levels may contribute to the development of metabolic abnormalities, but prospective studies evaluating the association between childhood RBP4 levels and metabolic syndrome (MS) in adulthood are lacking. We investigated whether RBP4 levels during childhood predict cardiometabolic risk at 10-year follow-up. METHODS: The relationships between RBP4 levels, the established adipokines (leptin and adiponectin) and the components of MS were examined in 3445 school-aged children recruited in 2004 for the Beijing Child and Adolescent Metabolic Syndrome study...
May 14, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29733056/asociaci%C3%A3-n-de-leptina-con-factores-cardiometab%C3%A3-licos-en-escolares-y-adolescentes-con-hiperplasia-suprarrenal-cong%C3%A3-nita
#7
Jessie Nallely Zurita-Cruz, Miguel Ángel Villasís-Keever, Leticia Damasio-Santana, Leticia Manuel-Apolinar, Rosalba Ferrusca-Ceja, Elisa Nishimura-Meguro, Aleida de J Rivera-Hernández, Eulalia Garrido-Magaña
Introducción: En la hiperplasia suprarrenal congénita (HSC), la obesidad, la hiperinsulinemia y los niveles de leptina se encuentran incrementados. Objetivo: Identificar la frecuencia de los factores de riesgo cardiometabólico (FRC) en niños y adolescentes con HSC y explorar la relación con los niveles de leptina. Método: Estudio transversal de 40 pacientes a quienes se realizó somatometría y evaluación de glucosa, insulina, triglicéridos, 17-hidroxiprogesterona, leptina, colesterol HDL y LDL en ayuno...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29721071/adipocyte-derived-exosomal-mir-27a-induces-insulin-resistance-in-skeletal-muscle-through-repression-of-ppar%C3%AE
#8
Yang Yu, Hongwei Du, Shengnan Wei, Linjing Feng, Junnan Li, Fan Yao, Ming Zhang, Grant M Hatch, Li Chen
The mechanism by which adipocyte-derived endocrine factors promote insulin resistance in skeletal muscle are not fully understood. MiR-27a is highly expressed in sera of obese individuals with prediabetes and T2DM, and mainly derived by adipose tissues. Thus, miR-27a secreted into circulation by adipose tissue may regulate insulin resistance in skeletal muscle. Methods: The association between miR-27a and insulin resistance in skeletal muscle was determined in obese children, high-fat diet-induced miR-27a knockdown obese mice, db/db mice and C2C12 cells overexpressing miR-27a...
2018: Theranostics
https://www.readbyqxmd.com/read/29679223/association-between-lepr-fto-mc4r-and-pparg-2-polymorphisms-with-obesity-traits-and-metabolic-phenotypes-in-school-aged-children
#9
Sílvia M Almeida, José M Furtado, Paulo Mascarenhas, Maria E Ferraz, José C Ferreira, Mariana P Monteiro, Manuel Vilanova, Fernando P Ferraz
PURPOSE: Evaluate the relationship of leptin receptor (LEPR) rs1137101, fat mass obesity-associated (FTO) receptors 9939609, melanocortin-4 receptors (MC4R) rs2229616 and rs17782313, and proliferator-activated receptor-gamma (PPARG) rs1801282 with clinical and metabolic phenotypes in prepubertal children. RESEARCH QUESTION: What is the effect of polymorphisms on clinical and metabolic phenotypes in prepubertal children? METHODS: A cross-sectional descriptive study was performed to evaluate anthropometric features, percentage body fat (%BF), biochemical parameters, and genotype in 773 prepubertal children...
June 2018: Endocrine
https://www.readbyqxmd.com/read/29668472/obesity-in-childhood-and-adolescence-genetic-factors
#10
Marko Kostovski, Velibor Tasic, Nevena Laban, Momir Polenakovic, Dragan Danilovski, Zoran Gucev
Obesity and excess weight are a pandemic phenomenon in the modern world. Childhood and adolescent obesity often ends up in obesity in adults. The costs of obesity and its consequences are staggering for any society, crippling for countries in development. Childhood obesity is also widespread in Macedonia. Metabolic syndrome, dyslipidemia and carbohydrate intolerance are found in significant numbers. Parents and grandparents are often obese. Some of the children are either dysmorphic, or slightly retarded. We have already described patients with Prader-Willi syndrome, Bardet-Biedl syndrome or WAGR syndrome...
December 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/29649377/vitamin-d-status-and-cardiovascular-risk-in-obesity-effect-of-physical-activity-in-nonvitamin-d-supplemented-adolescents
#11
Md Jobayer Hossain, Alexa Levinson, Donald George, Jose Canas, Seema Kumar, P Babu Balagopal
BACKGROUND: The relationship among inadequate vitamin D status, obesity, and cardiometabolic risk and the potential impact of physical activity-based interventions on vitamin D status are poorly characterized in children. This study aimed to address these issues. METHODS: We studied a total of 21 adolescents (15 obese and 6 normal weight; age: 14-18 years; Tanner stage>IV). Adolescents with obesity (n = 15) underwent a randomized controlled (8 in the intervention group and 7 in the control group) 3-month physical activity-based lifestyle intervention...
May 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29648999/cord-blood-klotho-levels-are-inversely-associated-with-leptin-in-healthy-latino-neonates-at-risk-for-obesity
#12
Janet M Wojcicki, Aric A Prather, Elissa Epel, Dan Wang, Dena B Dubal
BACKGROUND: Klotho serum levels reflect nutritional state in adults including obesity and anorexia. The relationship between cord blood klotho levels at birth and parameters of growth including anthropometrics are not known. METHODS: We evaluated the relationship between cord blood klotho, leptin and adipocyte hormones and infant, child and maternal anthropometrics and maternal depression in a cohort of 73 children. Non-parametric tests were used to assess differences between dichotomous and categorical predictors and klotho levels and Spearman's rank coefficients were used to assess the relationship between klotho levels and continuous predictors...
April 25, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29575812/branched-chain-amino-acids-androgen-hormones-and-metabolic-risk-across-early-adolescence-a-prospective-study-in-project-viva
#13
Wei Perng, Sheryl L Rifas-Shiman, Marie-France Hivert, Jorge E Chavarro, Emily Oken
OBJECTIVE: This study aimed to examine the associations of two obesity-related metabolite patterns with changes in metabolic biomarkers during early adolescence. METHODS: Multivariable linear regression was used to examine associations of branched chain amino acid (BCAA) and androgen hormone patterns with changes in glycemia (fasting glucose, insulin, homeostatic model assessment of insulin resistance), adipokines (leptin, adiponectin), inflammation (C-reactive protein, interleukin-6), lipid profile, and blood pressure during ∼5 years of follow-up among 213 children aged 6 to 10 years at baseline...
May 2018: Obesity
https://www.readbyqxmd.com/read/29571590/cardiovascular-risk-biomarkers-and-metabolically-unhealthy-status-in-prepubertal-children-comparison-of-definitions
#14
A I Rupérez, J Olza, M Gil-Campos, R Leis, G Bueno, C M Aguilera, A Gil, L A Moreno
BACKGROUND AND AIMS: The early onset of cardio-metabolic abnormalities, known as metabolically unhealthy (MU) status, is highly associated with obesity and cardiovascular disease (CVD), as well as with increased morbidity and mortality later in life. Given the lack of a consensus MU classification for prepubertal children, we aimed to compare available MU definitions in terms of their association with CVD risk biomarkers. METHODS AND RESULTS: A total of 930 prepubertal children (622 with overweight/obesity, 462 males) aged 5-10...
May 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29568105/early-childhood-bmi-trajectories-in-monogenic-obesity-due-to-leptin-leptin-receptor-and-melanocortin-4-receptor-deficiency
#15
Katja Kohlsdorf, Adriana Nunziata, Jan-Bernd Funcke, Stephanie Brandt, Julia von Schnurbein, Heike Vollbach, Belinda Lennerz, Maria Fritsch, Susanne Greber-Platzer, Elke Fröhlich-Reiterer, Manuel Luedeke, Guntram Borck, Klaus-Michael Debatin, Pamela Fischer-Posovszky, Martin Wabitsch
OBJECTIVE: To evaluate whether early childhood body mass index (BMI) is an appropriate indicator for monogenic obesity. METHODS: A cohort of n = 21 children living in Germany or Austria with monogenic obesity due to congenital leptin deficiency (group LEP, n = 6), leptin receptor deficiency (group LEPR, n = 6) and primarily heterozygous MC4 receptor deficiency (group MC4R, n = 9) was analyzed. A control group (CTRL) was defined that consisted of n = 22 obese adolescents with no mutation in the above mentioned genes...
February 27, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29476734/bioactive-leptin-is-stronger-related-to-parameters-of-fat-mass-and-distribution-than-conventionally-measured-leptin-findings-from-a-longitudinal-study-in-obese-children-participating-in-a-lifestyle-intervention
#16
Petra Niklowitz, Juliane Rothermel, Nina Lass, Andre Barth, Thomas Reinehr
OBJECTIVE: This study analyzed the relationships between bioactive leptin, conventionally measured leptin, and parameters of fat mass and distribution in obese children before and after weight reduction. METHODS: We determined bioactive leptin (bioLep), conventional measured leptin (conLep), weight, height, body fat based on skinfold measurements and bioimpedance analyses, waist circumference (wc), and pubertal stage in 88 obese children participating in a lifestyle intervention at baseline and one year later...
May 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29464548/leptin-involvement-in-primary-brain-and-pituitary-tumors-therapeutic-potential-prognostic-value-and-proposed-diagnostic-application
#17
REVIEW
Christos Bikis, Theodora Tzanavari, Krystallenia I Alexandraki, Stamatios Theocharis
Brain tumors are associated with increased mortality and morbidity and are the most common cancer type in children and young adults. The present review focuses on the interplay between leptin, the most extensively studied adipokine, and the onset, development, and treatment of primary brain and intracranial tumors. The two main mechanisms for increased leptin levels in intracranial tumor survivors, leptin resistance caused by hypothalamic damage, or secondary to obesity, are discussed. The contradicting mechanistic observations on leptin being able to both promote tumorinogenesis (e...
February 20, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29445241/is-early-life-exposure-to-polyomaviruses-and-herpesviruses-associated-with-obesity-indices-and-metabolic-traits-in-childhood
#18
Marianna Karachaliou, Silvia de Sanjose, Tim Waterboer, Theano Roumeliotaki, Maria Vassilaki, Katerina Sarri, Vasiliki Leventakou, Marina Vafeiadi, Georgia Chalkiadaki, Eftichia Stiakaki, Angelika Michel, Michael Pawlita, Manolis Kogevinas, Leda Chatzi
BACKGROUND: Evidence for an infectious origin of obesity is emerging. We explored whether common viruses were associated with obesity and metabolic traits. METHODS: We used cross-sectional (n = 674) and prospective (n = 440) data from children participating at the 4 and 6 years of age follow-up in the Rhea birth cohort. Presence of IgG antibodies to ten polyomaviruses (BKPyV, JCPyV, KIPyV, WUPyV, HPyV6, HPyV7, TSPyV, MCPyV, HPyV9, and HPyV10) and four herpesviruses (EBV, CMV, HSV-1, and HSV-2) were measured at age 4...
January 30, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29412799/correlation-between-serum-leptin-and-its-gene-expression-to-the-anthropometric-measures-in-overweight-and-obese-children
#19
Maha K Eldosouky, Azza M Abdu Allah, Abeer AbdElmoneim, Najat Saaeid Al-Ahmadi
Obesity is a multifactor disorder with evidence supporting the role of the genetic factor in its etiology. The present study evaluates the relationship between leptin G2548A (rs7799039) and leptin receptors (Gln223Arg (rs1137101) genotyping and its leptin level and the risk of childhood obesity. This case-control study was conducted on 168 overweight and obese Saudi children and 126 non obese one served as control. Fasting insulin, leptin, blood glucose, lipid profile levels were measured. HOMA- IR, and BMI were assessed...
January 31, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29410008/changes-in-eating-behavior-and-plasma-leptin-in-children-with-obesity-participating-in-a-family-centered-lifestyle-intervention
#20
Tamara R Cohen, Tom J Hazell, Catherine A Vanstone, Celia Rodd, Hope A Weiler
The goal of childhood obesity lifestyle interventions are to positively change body composition, however it is unknown if interventions also modulate factors that are related to energy intake. This study aimed to examine changes in eating behaviors and plasma leptin concentrations in overweight and obese children participating in a 1-year family-centered lifestyle intervention. Interventions were based on Canadian diet and physical activity (PA) guidelines. Children were randomized to 1 of 3 groups: Control (Ctrl; no intervention), Standard treatment (StnTx: 2 servings milk and alternatives/day (d), 3x/wk weight-bearing PA), or Modified treatment (ModTx: 4 servings milk and alternatives/day; daily weight-bearing PA)...
June 1, 2018: Appetite
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