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Dexamethasone suppression

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https://www.readbyqxmd.com/read/28526237/small-molecule-inhibition-of-wnt-signaling-abrogates-dexamethasone-induced-phenotype-of-primary-human-trabecular-meshwork-cells
#1
Sarah D Ahadome, Chi Zhang, Elizabeth Tannous, James Shen, Jie J Zheng
Trabecular meshwork (TM) cells are the governing regulators of the TM structure. When the functionality of these cells is impaired, the structure of the TM is perturbed, which often results in increased ocular hypertension. High intraocular pressure is the most significant risk factor for steroid-induced glaucoma. Dexamethasone (Dex) induced phenotype of TM cells is widely utilized as a model system to gain insight into mechanisms underlying damaged TM in glaucoma. In this study, to assess the possible role of the abnormal Wnt signaling in steroid-induced glaucoma, we analyzed the effects of small-molecule Wnt signaling modulators on Dex-induced expression extracellular matrix proteins of primary human TM cells...
May 16, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28523344/role-of-g3bp1-in-glucocorticoid-receptor-mediated-microrna-15b-and-microrna-23a-biogenesis-in-endothelial-cells
#2
Hoi-Hin Kwok, Po-Ying Poon, Kylie Hin-Man Mak, Lin-Yao Zhang, Pei Liu, Huoming Zhang, Nai-Ki Mak, Patrick Ying-Kit Yue, Ricky Ngok-Shun Wong
MicroRNAs (miRNAs) are a family of non-coding RNAs that play crucial roles in regulating various normal cellular responses. Recent studies revealed that the canonical miRNA biogenesis pathway is subject to sophisticated regulation. Hormonal control of miRNA biogenesis by androgen and estrogen has been demonstrated, but the direct effects of the glucocorticoid receptor (GR) on miRNA biogenesis are unknown. This study revealed the role of GR in miRNA maturation. We showed that two GR agonists, dexamethasone and ginsenoside-Rg1 rapidly suppressed the expression of mature miR-15b, miR-23a, and miR-214 in human endothelial cells...
May 18, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28515280/airway-epithelial-cells-are-crucial-targets-of-glucocorticoids-in-a-mouse-model-of-allergic-asthma
#3
Carina Klaßen, Anna Karabinskaya, Lien Dejager, Sabine Vettorazzi, Justine Van Moorleghem, Fred Lühder, Sebastiaan H Meijsing, Jan P Tuckermann, Hanibal Bohnenberger, Claude Libert, Holger M Reichardt
Although glucocorticoids (GCs) are a mainstay in the clinical management of asthma, the target cells that mediate their therapeutic effects are unknown. Contrary to our expectation, we found that GC receptor (GR) expression in immune cells was dispensable for successful therapy of allergic airway inflammation (AAI) with dexamethasone. Instead, GC treatment was compromised in mice expressing a defective GR in the nonhematopoietic compartment or selectively lacking the GR in airway epithelial cells. Further, we found that an intact GR dimerization interface was a prerequisite for the suppression of AAI and airway hyperresponsiveness by GCs...
May 17, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28511863/expression-of-tnf-%C3%AE-system-members-in-bovine-ovarian-follicles-and-the-effects-of-tnf-%C3%AE-or-dexamethasone-on-preantral-follicle-survival-development-and-ultrastructure-in-vitro
#4
A W B Silva, R P Ribeiro, V G Menezes, R S Barberino, J R S Passos, A M P Dau, J J N Costa, L R F Melo, F T G Bezerra, M A M Donato, C A Peixoto, M H T Matos, P B D Gonçalves, R van den Hurk, J R V Silva
This study was conducted to detect the protein expression of TNF-α system members (TNF-α/TNFR1/TNFR2) in bovine ovarian follicles and to evaluate the effects of TNF-α or dexamethasone on the survival and growth of primordial follicles in vitro, as well as on gene expression in cultured ovarian tissue. It was hypothesized that TNF-α induces follicular atresia in ovarian tissues cultured in vitro, and that dexamethasone suppresses the production of endogenous TNF-α, which can improve follicle viability in vitro...
May 6, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28500825/which-type-2-diabetes-mellitus-patients-should-be-screened-for-subclinical-cushing-s-syndrome
#5
Güven Barış Cansu, Sevgi Atılgan, Mustafa Kemal Balcı, Ramazan Sarı, Sebahat Özdem, Hasan Ali Altunbaş
OBJECTIVE: Diabetes or impaired glucose tolerance are common in patients with Cushing's syndrome (CS). In this study we investigated the incidence of subclinical Cushing's syndrome (SCS) in type 2 diabetic patients with poor and good metabolic control and the relationship between blood glucose and cortisol levels. DESIGN: A total of 400 type 2 diabetes mellitus (T2DM) patients (Group A, HbA1c ≥8%, n=250; Group B, HbA1c ≤6.5%, n=150) were included in the study...
January 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28491690/dexamethasone-suppresses-long-qt-phenotype-in-patient-with-acute-promyelocytic-leukemia-treated-with-arsenic
#6
Jeffrey R Winterfield, David J Milan
No abstract text is available yet for this article.
July 2016: HeartRhythm Case Reports
https://www.readbyqxmd.com/read/28490236/cinnamyl-alcohol-the-bioactive-component-of-chestnut-flower-absolute-inhibits-adipocyte-differentiation-in-3t3-l1-cells-by-downregulating-adipogenic-transcription-factors
#7
Dae Il Hwang, Kyung-Jong Won, Do-Yoon Kim, Bokyung Kim, Hwan Myung Lee
The extract of chestnut (Castanea crenata var. dulcis) flower (CCDF) has antioxidant and antimelanogenic properties, but its anti-obesity properties have not been previously examined. In this study, we tested the effect of CCDF absolute on adipocyte differentiation by using 3T3-L1 cells and determining the bioactive component of CCDF absolute in 3T3-L1 cell differentiation. CCDF absolute (0.1-100[Formula: see text][Formula: see text]g/mL) did not change 3T3-L1 cell viability. At 50[Formula: see text][Formula: see text]g/mL and 100[Formula: see text][Formula: see text]g/mL, the absolute significantly reduced the accumulation of lipid droplets in 3T3-L1 cells that were induced by culture in medium containing 3-isobutyl-1-methylxanthine/dexamethasone/insulin (MDI)...
May 11, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28488329/phosphodiesterase-1b-deletion-confers-depression-like-behavioral-resistance-separate-from-stress-related-effects-in-mice
#8
Jillian R Hufgard, Michael T Williams, Charles V Vorhees
Phosphodiesterase-1b (Pde1b) is highly expressed in striatum, dentate gyrus, CA3, and substantia nigra. In a new Floxed Pde1b x Cre(CMV) global knock-out (KO) mouse model we show an immobility resistance phenotype that recapitulates that found in constitutive Pde1b KO mice. We use this new mouse model to show that the resistance to acute stress-induced depression-like phenotype is not the product of changes in locomotor activity or reactivity to other stressors (learned helplessness, novelty suppressed feeding, or dexamethasone suppression), and is not associated with anhedonia using the sucrose preference test...
May 10, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28473245/the-development-and-use-of-a-drug-induced-immunosuppressed-rat-model-to-screen-phela-for-mechanism-of-immune-stimulation
#9
Makhotso Rose Lekhooa, Andrew Walubo, Jan B du Plessis, Motlalepula Gilbert Matsabisa
ETHNOPHARMACOLOGY RELEVANCY: Phela, is code name for a medicinal product made from four South African traditional medicinal plants (Clerodendrum glabrum E. Mey, Polianthes tuberosa (Linn.), Rotheca myricoides (Hochst.) Steane & Mabb. and Senna occidentalis (L.) Link). All these plants have established traditional use in a wide spectrum of diseases. It is under development for use as an immune booster in immunocompromised patients, which includes patients with the human immunodeficiency virus (HIV)...
May 1, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28471397/mir-365-ameliorates-dexamethasone-induced-suppression-of-osteogenesis-in-mc3t3-e1-cells-by-targeting-hdac4
#10
Daohua Xu, Yun Gao, Nan Hu, Longhuo Wu, Qian Chen
Glucocorticoid administration is the leading cause of secondary osteoporosis. In this study, we tested the hypotheses that histone deacetylase 4 (HDAC4) is associated with glucocorticoid-induced bone loss and that HDAC4 dependent bone loss can be ameliorated by miRNA-365. Our previous studies showed that miR-365 mediates mechanical stimulation of chondrocyte proliferation and differentiation by targeting HDAC4. However, it is not clear whether miR-365 has an effect on glucocorticoid-induced osteoporosis. We have shown that, in MC3T3-E1 osteoblasts, dexamethasone (DEX) treatment decreased the expression of miR-365, which is accompanied by the decrease of cell viability in a dose-dependent manner...
May 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28468767/cardiovascular-events-in-patients-with-mild-autonomous-cortisol-secretion-analysis-with-artificial-neural-networks
#11
Valentina Morelli, Serena Palmieri, Andrea Lania, Alberto Tresoldi, Sabrina Corbetta, Elisa Cairoli, Cristina Eller-Vainicher, Maura Arosio, Massimiliano Copetti, Enzo Grossi, Iacopo Chiodini
BACKGROUND: The independent role of mild autonomous cortisol secretion (ACS) in influencing the cardiovascular event (CVE) occurrence is a topic of interest. We investigated the role of mild ACS in the CVE occurrence in patients with adrenal incidentaloma (AI) by the standard statistics and the artificial neural networks (ANNs). METHODS: We analyzed a retrospective record of 518 AI patients. Data regarding cortisol levels after 1mg-dexamethasone suppression (1-mgDST) and the presence of obesity (OB), hypertension (AH), type-2 diabetes (T2DM), dyslipidaemia (DL), familial CVE history, smoking habit and CVE were collected...
May 3, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28468286/clinical-utility-of-the-adrenocorticotropin-stimulation-test-with-without-dexamethasone-suppression-for-definitive-and-subtype-diagnosis-of-primary-aldosteronism
#12
Kosuke Inoue, Masao Omura, Chiho Sugisawa, Yuya Tsurutani, Jun Saito, Tetsuo Nishikawa
The adrenocorticotropin (ACTH) stimulation test (AST) has been reported to be useful for diagnosing primary aldosteronism (PA), particularly for differentiating PA subtypes under 1-mg dexamethasone suppression (DS). The aim of our study was to clarify the effect of 1-mg DS on AST results. A retrospective cohort study was conducted using data for 48 patients (PA: 30/48). We estimated the difference in plasma aldosterone concentration (PAC) responsiveness to ACTH stimulation with single (AST alone) and combined (AST under 1-mg DS) tests within the same patient...
April 30, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28466059/inducible-transgenic-tobacco-system-to-study-the-mechanisms-underlying-chlorosis-mediated-by-the-silencing-of-chloroplast-heat-shock-protein-90
#13
Sachin Ashok Bhor, Chika Tateda, Tomofumi Mochizuki, Ken-Taro Sekine, Takashi Yaeno, Naoto Yamaoka, Masamichi Nishiguchi, Kappei Kobayashi
Chlorosis is one of the most common symptoms of plant diseases, including those caused by viruses and viroids. Recently, a study has shown that Peach latent mosaic viroid (PLMVd) exploits host RNA silencing machinery to modulate the virus disease symptoms through the silencing of chloroplast-targeted heat shock protein 90 (Hsp90C). To understand the molecular mechanisms of chlorosis in this viroid disease, we established an experimental system suitable for studying the mechanism underlying the chlorosis induced by the RNA silencing of Hsp90C in transgenic tobacco...
March 2017: Virusdisease
https://www.readbyqxmd.com/read/28465233/aesculin-modulates-bone-metabolism-by-suppressing-receptor-activator-of-nf-%C3%AE%C2%BAb-ligand-rankl-induced-osteoclastogenesis-and-transduction-signals
#14
Xiao-Li Zhao, Lin-Feng Chen, Zhen Wang
Aesculin (AES), a coumarin compound derived from Aesculus hippocasanum L, is reported to exert protective role against inflammatory diseases, gastric disease and cancer. However, direct effect of AES in bone metabolism is deficient. In this study, we examined the effects of AES on osteoclast (OC) differentiation in receptor activator of NF-κB ligand (RANKL)-induced RAW264.7 cells. AES inhibits the OC differentiation in both dose- and time-dependent manner within non-toxic concentrations, as analyzed by Tartrate Resistant Acid Phosphatase (TRAP) staining...
June 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28464105/effects-of-dexamethasone-treatment-and-respiratory-vaccination-on-rectal-temperature-complete-blood-count-and-functional-capacities-of-neutrophils-in-beef-steers
#15
H D Hughes, J A Carroll, N C Burdick Sanchez, S L Roberts, P R Broadway, N D May, M A Ballou, J T Richeson
The objective of this research was to examine the effects of dexamethasone (DEX) treatment on various aspects of immunity following administration of a multivalent respiratory vaccine, using a model intended to mimic acute versus chronic stress. Angus × Hereford steers ( = 32; 209 ± 8 kg) were stratified by BW and randomly assigned to 1 of 3 treatments: 1) acute stress (ACU), in which 0.5 mg/kg BW DEX was intravenously administered at 1000 h only on d 0; 2) chronic stress (CHR), in which 0.5 mg/kg BW DEX was intravenously administered at 1000 h on d -3 to 0; or 3) control (CON), in which no DEX was administered...
April 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28458907/hypersecretion-of-acth-and-prl-from-pituitary-adenoma-in-men1-adequately-managed-by-medical-therapy
#16
Shinsuke Uraki, Hiroyuki Ariyasu, Asako Doi, Hiroto Furuta, Masahiro Nishi, Takeshi Usui, Hiroki Yamaue, Takashi Akamizu
SUMMARY: A 54-year-old man had gastrinoma, parathyroid hyperplasia and pituitary tumor. His family history indicated that he might have multiple endocrine neoplasia type 1 (MEN1). MEN1 gene analysis revealed a heterozygous germline mutation (Gly156Arg). Therefore, we diagnosed him with MEN1. Endocrinological tests revealed that his serum prolactin (PRL) and plasma adrenocorticotropic hormone (ACTH) levels were elevated to 1699 ng/mL and 125 pg/mL respectively. Immunohistochemical analysis of the resected pancreatic tumors revealed that the tumors did not express ACTH...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28458897/armc5-mutation-in-a-portuguese-family-with-primary-bilateral-macronodular-adrenal-hyperplasia-pbmah
#17
Teresa Rego, Fernando Fonseca, Stéphanie Espiard, Karine Perlemoine, Jérôme Bertherat, Ana Agapito
SUMMARY: PBMAH is a rare etiology of Cushing syndrome (CS). Familial clustering suggested a genetic cause that was recently confirmed, after identification of inactivating germline mutations in armadillo repeat-containing 5 (ARMC5) gene. A 70-year-old female patient was admitted due to left femoral neck fracture in May 2014, in Orthopedics Department. During hospitalization, hypertension (HTA) and hypokalemia were diagnosed. She presented with clinical signs of hypercortisolism and was transferred to the Endocrinology ward for suspected CS...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28458423/effect-of-angelica-glauca-essential-oil-on-allergic-airway-changes-induced-by-histamine-and-ovalbumin-in-experimental-animals
#18
Shilpa Sharma, Vijaykumar P Rasal, Paragouda A Patil, Rajesh K Joshi
OBJECTIVE: Angelica glauca Edgew (Apiaceae) is used in traditional medicine for treatment of several diseases including bronchial asthma. The present investigation was aimed to evaluate broncho-relaxant activity of A. glauca essential oil in histamine and ovalbumin (OVA)-induced broncho constriction in experimental animals. MATERIALS AND METHODS: Airway was induced using histamine aerosol in guinea pigs (n = 24) and OVA aerosol in albino mice (n = 24). The number of inflammatory cells, namely, absolute eosinophils count in blood, total immunoglobulin E (IgE) in serum, eosinophils, and neutrophils in bronchoalveolar lavage fluid (BALF) and histopathological examination of lung tissues were investigated in A...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28450865/distinct-effects-of-dexamethasone-on-human-natural-killer-cell-responses-dependent-on-cytokines
#19
David J Morgan, Daniel M Davis
Glucocorticoids (GCs) have long been known to be immune suppressive and synthetic variants are widely used in the treatment of inflammatory disorders. Here, we report that, while suppressing the initial production of interferon-γ (IFN-γ), the synthetic GC dexamethasone (Dex) enhances the proliferation and survival of natural killer (NK) cells stimulated with interleukin-2 (IL-2) + interleukin-12 (IL-12). Inhibition of mTOR complex 1 by rapamycin revealed the immunosuppressive activity of Dex was independent from the effect of enhancing NK cell proliferation...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28449321/a-review-of-associated-controversies-surrounding-glucocorticoid-use-in-veterinary-emergency-and-critical-care
#20
Maya A Aharon, Jennifer E Prittie, Kate Buriko
OBJECTIVE: To review the literature in human and veterinary medicine regarding the indications for, efficacy of, and controversies surrounding glucocorticoid (GC) administration in the emergency and critical care (ECC) setting, and to provide an overview of the most commonly used synthetic GC formulations. MEDICATIONS: Synthetic GCs vary in GC and mineralocorticoid potency, hypothalamic pituitary axis suppression, duration of action, route of administration, and clinical indication for use...
May 2017: Journal of Veterinary Emergency and Critical Care
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