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https://www.readbyqxmd.com/read/28340474/studying-the-effects-of-natural-extracts-with-metabolomics-a-longitudinal-study-on-the-supplementation-of-healthy-rats-with-polygonum-cuspidatum-sieb-et-zucc
#1
Gregorio Peron, Jalal Uddin, Matteo Stocchero, Stefano Mammi, Elisabetta Schievano, Stefano Dall'Acqua
BACKGROUND: A longitudinal study was performed to evaluate the effects of Polygonum cuspidatum extract (standardized at 20% resveratrol) supplementation on healthy rats. The effects were explored by monitoring urinary metabolome changes using UPLC-HRMS and (1)H NMR-based approaches. The aim of the study was to explore the effects of P. cuspidatum supplementation on a healthy animal model using metabolomics, in order to determine possible modes of action and obtain information on bioactivity...
March 16, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28335380/vitamin-e-nicotinate
#2
REVIEW
Kimbell R Duncan, Yuichiro J Suzuki
Vitamin E refers to a family of compounds that function as lipid-soluble antioxidants capable of preventing lipid peroxidation. Naturally occurring forms of vitamin E include tocopherols and tocotrienols. Vitamin E in dietary supplements and fortified foods is often an esterified form of α-tocopherol, the most common esters being acetate and succinate. The vitamin E esters are hydrolyzed and converted into free α-tocopherol prior to absorption in the intestinal tract. Because its functions are relevant to many chronic diseases, vitamin E has been extensively studied in respect to a variety of diseases as well as cosmetic applications...
March 13, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28334709/micronutrients-essential-fatty-acids-and-bone-health-in-phenylketonuria
#3
Serwet Demirdas, Francjan J van Spronsen, Carla E M Hollak, J Hanneke van der Lee, Peter H Bisschop, Fred M Vaz, Nienke M Ter Horst, M Estela Rubio-Gozalbo, Annet M Bosch
INTRODUCTION: In phenylketonuria (PKU), a natural protein-restricted dietary treatment prevents severe cognitive impairment. Nutrient deficiencies may occur due to strict diet. This study is aimed at evaluating the dietary intake and blood concentrations of micronutrients and essential fatty acids (FA), bone mineral density (BMD) and fracture history in patients on long-term dietary treatment. METHODS: Sixty early diagnosed Dutch patients (aged 1-39 years) were included in a multi-center cross-sectional study...
March 24, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28334106/economic-injury-level-and-demography-based-control-timing-projection-of-spodoptera-litura-lepidoptera-noctuidae-at-different-growth-stages-of-arachis-hypogaea
#4
Shu-Jen Tuan, Chung-Chieh Lee, Li-Chen Tang, Pavel Saska
Spodoptera litura (F.), one of the most devastating pests in many Asian countries, is normally controlled by relying on chemical insecticides. To encourage an integrated pest management approach, we determined the economic injury level (EIL) for S. litura on peanut, Arachis hypogaea L., by larval infestation with late instars at different crop growth stages. The cumulative consumption rate of the fifth- and sixth-instars was used as the relative unit for the "Spodoptera injury equivalent" (SIE). The yield of marketable pods significantly decreased from 6...
February 17, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28333238/clustering-of-pcos-like-traits-in-naturally-hyperandrogenic-female-rhesus-monkeys
#5
D H Abbott, B H Rayome, D A Dumesic, K C Lewis, A K Edwards, K Wallen, M E Wilson, S E Appt, J E Levine
STUDY QUESTION: Do naturally occurring, hyperandrogenic (≥1 SD of population mean testosterone, T) female rhesus monkeys exhibit traits typical of women with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: Hyperandrogenic female monkeys exhibited significantly increased serum levels of androstenedione (A4), 17-hydroxyprogesterone (17-OHP), estradiol (E2), LH, antimullerian hormone (AMH), cortisol, 11-deoxycortisol and corticosterone, as well as increased uterine endometrial thickness and evidence of reduced fertility, all traits associated with PCOS...
March 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28333071/combined-effects-of-curcumin-and-lycopene-or-bixin-in-yoghurt-on-inhibition-of-ldl-oxidation-and-increases-in-hdl-and-paraoxonase-levels-in-streptozotocin-diabetic-rats
#6
Renata Pires Assis, Carlos Alberto Arcaro, Vânia Ortega Gutierres, Juliana Oriel Oliveira, Paulo Inácio Costa, Amanda Martins Baviera, Iguatemy Lourenço Brunetti
Combination therapy using natural antioxidants to manage diabetes mellitus and its complications is an emerging trend. The aim of this study was to investigate the changes promoted by treatment of streptozotocin (STZ)-diabetic rats with yoghurt enriched with the bioactives curcumin, lycopene, or bixin (the latter two being carotenoids). Antioxidants were administered individually, or as mixtures, and biomarkers of metabolic and oxidative disturbances, particularly those associated with cardiovascular risk, were assessed...
March 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28330423/geraniol-a-natural-monoterpene-ameliorates-hyperglycemia-by-attenuating-the-key-enzymes-of-carbohydrate-metabolism-in-streptozotocin-induced-diabetic-rats
#7
Sukumar Babukumar, Veerasamy Vinothkumar, Chandrasekaran Sankaranarayanan, Subramani Srinivasan
CONTEXT: Geraniol, an acyclic monoterpene alcohol is found in medicinal plants, is used traditionally for several medical purposes including diabetes. OBJECTIVES: The present study evaluates the antihyperglycemic potential of geraniol on key enzymes of carbohydrate metabolism in streptozotocin (STZ)-induced diabetic rats. MATERIALS AND METHODS: Diabetes was induced in experimental rats, by a single intraperitoneal (i.p) injection of STZ [40 mg/kg body weight (b...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28330243/micropropagation-and-validation-of-genetic-and-biochemical-fidelity-among-regenerants-of-nothapodytes-nimmoniana-graham-mabb-employing-issr-markers-and-hplc
#8
Lokesh Prakash, Sushil Kumar Middha, Sudipta Kumar Mohanty, Mallappa Kumara Swamy
An in vitro protocol has been established for clonal propagation of Nothapodytes nimmoniana which is an important source of Camptothecin (CPT). Elite source was identified based on the chemical potency to accumulate the optimum level of CPT. Different types and concentrations of plant growth regulators were used to study their effect on inducing multiple shoots from the explants regenerated from embryos of N. nimmoniana. Of these, a combination of N6-benzyladenine (0.2 mg L(-1)) and Indole-3-butyric acid (IBA) (0...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330091/optimization-of-regeneration-using-differential-growth-regulators-in-indica-rice-cultivars
#9
Samar Shekar R Sankepally, Bharat Singh
Paddy is a staple crop and being grown in major parts of India, but similarly it is facing some major challenges like abiotic stresses (drought, salinity, etc.) by which its productivity is greatly affected. De-husked seeds of 21 cultivars of indica rice were cultured onto MS medium for screening of their micropropagation capabilities. All the selected cultivars are being cultivated by farmers of Andhra Pradesh and Rajasthan states of India, these cultivars bear good quality of grain and high yield. Similarly, both states are facing the problem of drought so; we selected these cultivars for the micropropagation and transformation studies...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28329710/feeling-the-pressure-attitudes-about-volunteering-and-their-effect-on-civic-and-political-behaviors
#10
Leticia Bode
This article examines the evolving nature of volunteering among American youth, ages 12 to 17, focusing on emergent pressures to volunteer, as required by high schools or to improve one's employment or education prospects after graduation. Using survey data (N = 736, mean age = 14.78, 75.1% white, 49.1% female), it finds these pressures are prevalent, related to a desire to volunteer, and both of these motivations are positively associated with volunteering. It further concludes that volunteering supplements, rather than replaces or subsumes both online and offline political behaviors among youth...
March 19, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/28329106/evaluating-distinctions-in-the-assessment-of-late-life-disability
#11
Thomas M Gill, Christianna S Williams
Background: By including categories for accommodations and reduced frequency, to supplement earlier classifications of difficulty and dependence, a new 5-category functional scale has the potential to distinguish finer gradations in disability but the hierarchical nature and advantages of this scale over alternative scales are uncertain. Methods: Using data from the National Health and Aging Trends Study (N = 7,609), we conducted a series of: cross-sectional analyses that focused on the hierarchical consistency of responses in the 5-category scale; and longitudinal analyses that focused on predictive accuracy for mortality and functional dependence, comparing the 5-category scale with three simpler scales, having only three or four categories...
February 22, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28326561/hemoxcell-a-new-oxygen-carrier-usable-as-an-additive-for-mesenchymal-stem-cell-culture-in-platelet-lysate-supplemented-media
#12
Fiona Le Pape, Lucie Cosnuau-Kemmat, Gaëlle Richard, Frédéric Dubrana, Claude Férec, Franck Zal, Elisabeth Leize, Pascal Delépine
Human mesenchymal stem cells (MSCs) are promising candidates for therapeutic applications such as tissue engineering. However, one of the main challenges is to improve oxygen supply to hypoxic areas to reduce oxygen gradient formation while preserving MSC differentiation potential and viability. For this purpose, a marine hemoglobin, HEMOXCell, was evaluated as an oxygen carrier for culturing human bone marrow MSCs in vitro for future three-dimensional culture applications. Impact of HEMOXCell on cell growth and viability was assessed in human platelet lysate (hPL)-supplemented media...
March 22, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28325999/natural-sea-salt-consumption-confers-protection-against-hypertension-and-kidney-damage-in-dahl-salt-sensitive-rats
#13
Bog-Hieu Lee, Ae-Ri Yang, Mi Young Kim, Sara McCurdy, William A Boisvert
Although sea salts are widely available to consumers nowadays, whether its consumption over refined salt has any real health benefits is largely unknown. This study was conducted to compare hypertension-inducing propensity of natural sea salt (SS) to refined salt (RS) in a well-established animal model of hypertension. Five groups of male Dahl salt-sensitive rats were fed rat chow diet supplemented with various amounts of salt for 15 weeks. The groups were: control (CON, n = 10), 4% RS (RS4), 4% SS (SS4), 8% RS (RS8), 8% SS (SS8) (n = 12 for each group)...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28320080/interlaboratory-trial-for-the-measurement-of-total-cobalt-in-equine-urine-and-plasma-by-icp-ms
#14
Marie-Agnes Popot, Emmie N M Ho, Natali Stojiljkovic, Florian Bagilet, Pierre Remy, Pascal Maciejewski, Benoit Loup, George H M Chan, Sabine Hargrave, Rick M Arthur, Charlie Russo, James White, Pamela Hincks, Clive Pearce, George Ganio, Paul Zahra, David Batty, Mark Jarrett, Lydia Brooks, Lise-Anne Prescott, Ludovic Bailly-Chouriberry, Yves Bonnaire, Terence S M Wan
Cobalt is an essential mineral micronutrient and is regularly present in equine nutritional and feed supplements. Therefore, cobalt is naturally present at low concentrations in biological samples. The administration of cobalt chloride is considered to be blood doping and is thus prohibited. In order to control the misuse of cobalt, it was mandatory to establish an international threshold for cobalt in plasma and/or in urine. To achieve this goal an international collaboration, consisting of an interlaboratory comparison, between 5 laboratories for the urine study and 8 laboratories for the plasma study has been undertaken...
March 20, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28320069/usefulness-of-laboratory-and-radiological-investigations-in-the-management-of-supraventricular-tachycardia
#15
Aadith Ashok, Miguel Cabalag, David McD Taylor
OBJECTIVE: Although ED patients presenting with supraventricular tachycardia (SVT) are commonly investigated, the value of these investigations has been questioned. We aimed to determine the frequency and utility of investigations in patients with SVT. METHODS: We undertook an explicit retrospective medical record audit of patients with SVT who presented to a single ED (January 2004 to June 2014). Data on demographics, presenting complaints, investigations and outcomes were extracted...
March 20, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/28306420/ventriculo-ureteral-shunt-insertion-using-percutaneous-nephrostomy-a-novel-minimally-invasive-option-in-a-patient-with-chronic-hydrocephalus-complicated-by-multiple-distal-ventriculoperitoneal-shunt-failures
#16
Ashok Pillai, Georgie Mathew, Sivasankaran Nachimuthu, Sanjeevan Vasudevan Kalavampara
The management of ventriculoperitoneal (VP) shunt failure is a common problem in neurosurgical practice. On occasion, extraperitoneal sites for CSF diversion are required when shunting to the peritoneal cavity has failed after multiple attempts. The authors report a novel minimally invasive procedure allowing cannulation of the ureter for the purpose of ventriculo-ureteral (VU) shunting. Sixteen years prior to presentation, this 46-year-old woman had contracted tuberculous meningitis and had chronic hydrocephalus, with multiple distal shunt failures in recent months...
March 17, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28303364/effects-of-pomegranate-juice-on-cardiovascular-risk-factors-in-patients-with-metabolic-syndrome-a-double-blinded-randomized-crossover-controlled-trial
#17
Hossein Moazzen, Mohammad Alizadeh
The aim of this study is to investigate the simultaneous effect of pomegranate juice on components of the metabolic syndrome, including high sensitive C-reactive protein (hs-CRP) as an inflammatory index and glycemic and lipid profile indices in patients with metabolic syndrome. In a double- blind 2*2 crossover study, 30 individuals suffering from metabolic syndrome received a daily dose of 500 mL pomegranate juice for a period of one week. After one week of wash out period, they received a placebo for one week...
March 16, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/28303008/an-analysis-of-echinacea-chloroplast-genomes-implications-for-future-botanical-identification
#18
Ning Zhang, David L Erickson, Padmini Ramachandran, Andrea R Ottesen, Ruth E Timme, Vicki A Funk, Yan Luo, Sara M Handy
Echinacea is a common botanical used in dietary supplements, primarily to treat upper respiratory tract infections and to support immune function. There are currently thought to be nine species in the genus Echinacea. Due to very low molecular divergence among sister species, traditional DNA barcoding has not been successful for differentiation of Echinacea species. Here, we present the use of full chloroplast genomes to distinguish between all 9 reported species. Total DNA was extracted from specimens stored at the National Museum of Natural History, Smithsonian Institution, which had been collected from the wild with species identification documented by experts in the field...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28301842/early-life-nutritional-programming-of-health-and-disease-in-the-gambia
#19
Sophie E Moore
BACKGROUND: Exposures during early life are increasingly being recognised as factors that play an important role in the aetiology of chronic non-communicable diseases (NCDs). The "Developmental Origins of Health and Disease" (DOHaD) hypothesis asserts that adverse early-life exposures - most notably unbalanced nutrition - leads to an increased risk for a range of NCDs and that disease risk is highest when there is a "mismatch" between the early- and later-life environments. Thus, the DOHaD hypothesis would predict highest risk in settings undergoing a rapid nutrition transition...
March 17, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28300756/oleanolic-acid-alters-multiple-cell-signaling-pathways-implication-in-cancer-prevention-and-therapy
#20
REVIEW
Lovro Žiberna, Dunja Šamec, Andrei Mocan, Seyed Fazel Nabavi, Anupam Bishayee, Ammad Ahmad Farooqi, Antoni Sureda, Seyed Mohammad Nabavi
Nowadays, much attention has been paid to diet and dietary supplements as a cost-effective therapeutic strategy for prevention and treatment of a myriad of chronic and degenerative diseases. Rapidly accumulating scientific evidence achieved through high-throughput technologies has greatly expanded the understanding about the multifaceted nature of cancer. Increasingly, it is being realized that deregulation of spatio-temporally controlled intracellular signaling cascades plays a contributory role in the onset and progression of cancer...
March 16, 2017: International Journal of Molecular Sciences
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