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https://www.readbyqxmd.com/read/29028078/a-natural-pharma-standard-supplement-formulation-to-control-treatment-related-toxicity-and-oxidative-stress-in-genitourinary-cancer-a-preliminary-study
#1
A Ledda, G Belcaro, M Dugall, R Luzzi, M Hosoi, B Feragalli, R Cotellese, V Cosentino, M Cosentino, R Eggenhoffner, M Pellizzato, A Fratter, L Giacomelli
OBJECTIVE: Oncological treatments are associated with toxicities that may decrease compliance to treatment in most genitourinary cancer patients. Supplementation with pharmaceutical-standardized supplement may be a supplementary method to control the side effects after chemo- and radiotherapy and the increased oxidative stress associated to treatments. This registry study evaluated a natural combination of supplements containing curcumin, cordyceps, and astaxanthin (Oncotris™) used as supplementary management in genitourinary cancer patients who had undergone oncological therapy...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29028075/safety-of-oral-alpha-lipoic-acid-treatment-in-pregnant-women-a-retrospective-observational-study
#2
E Parente, G Colannino, O Picconi, G Monastra
OBJECTIVE: Alpha-lipoic acid is a natural molecule, which directly or by means of its reduced form, dihydrolipoic acid, exerts antioxidant, anti-inflammatory and immunomodulatory activities, very helpful also in preventing miscarriage and preterm delivery. Used as dietary supplement alpha-lipoic acid was demonstrated to be safe for living organisms even when administered at high doses. However, no study was made so far to verify the safety of its continuous administration on a substantial number of pregnant women...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29027528/-nasal-glial-heterotopia-clinical-and-morphological-characteristics
#3
V P Bykova, A A Bakhtin, D P Polyakov, A S Yunusov, N A Daikhes
The paper describes a case of nasal glial heterotopia in a 10-month-old girl with a mixed (intranasal and subcutaneous) localization, which is accompanied by the divergence of the nasal bones. Histological examination supplemented by immunohistochemical reactions with antibodies to vimentin, S100 protein, neuron-specific enolase, as well as Ki-67 and smooth muscle actin confirmed the neural nature of the tumor. Fields of mature astrocytic glia including individual cells with neuronal differentiation were found among the fibrous and fibrovascular tissues...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/29023761/natural-vitamin-b12-and-fucose-supplementation-of-green-smoothies-with-edible-algae-and-related-quality-changes-during-their-shelf-life
#4
Noelia Castillejo, Ginés Benito Martínez Hernández, Valentina Goffi, Perla A Gómez, Encarna Aguayo, Francisco Artés, Francisco Artés Hernández
BACKGROUND: Some algae are an excellent source of vitamin B12, of special interest for vegetarian/vegan consumers, and of fucose to supplement fruit and vegetables beverages like smoothies. Nevertheless, the algae supplementation of smoothies may lead to possible quality changes during smoothie shelf life that needs to be studied. Therefore, the quality changes of fresh green smoothies supplemented (2.2%) with 9 edible algae (sea lettuce, kombu, wakame, thongweed, dulse, Irish moss, nori, spirulina and chlorella) were studied throughout 24 days at 5°C...
October 11, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29023699/using-host-species-traits-to-understand-the-consequences-of-resource-provisioning-for-host-parasite-interactions
#5
Daniel J Becker, Daniel G Streicker, Sonia Altizer
1.Supplemental food provided to wildlife by human activities can be more abundant and predictable than natural resources, and subsequent changes to wildlife ecology can have profound impacts on host-parasite interactions. Identifying traits of species associated with increases or decreases in infection outcomes with resource provisioning could improve assessments of wildlife most prone to disease risks in changing environments. 2.We conducted a phylogenetic meta-analysis of 342 host-parasite interactions across 56 wildlife species and three broad taxonomic groups of parasites to identify host-level traits that influence whether provisioning is associated with increases or decreases in infection...
October 10, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/29023392/disposition-metabolism-and-histone-deacetylase-and-acetyltransferase-inhibition-activity-of-tetrahydrocurcumin-and-other-curcuminoids
#6
Júlia T Novaes, Ryan Lillico, Casey L Sayre, Kalyanam Nagabushnam, Muhammed Majeed, Yufei Chen, Emmanuel A Ho, Ana Luísa de P Oliveira, Stephanie E Martinez, Samaa Alrushaid, Neal M Davies, Ted M Lakowski
Tetrahydrocurcumin (THC), curcumin and calebin-A are curcuminoids found in turmeric (Curcuma longa). Curcuminoids have been established to have a variety of pharmacological activities and are used as natural health supplements. The purpose of this study was to identify the metabolism, excretion, antioxidant, anti-inflammatory and anticancer properties of these curcuminoids and to determine disposition of THC in rats after oral administration. We developed a UHPLC-MS/MS assay for THC in rat serum and urine. THC shows multiple redistribution phases with corresponding increases in urinary excretion rate...
October 12, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/29023036/callus-induction-from-various-organs-of-dragon-fruit-apple-and-tomato-on-some-mediums
#7
Rumiyati, Sismindari, Endang Semiarti, Asri Fajar Milasari, Dheatika Karina Sari, Nia Fitriana, Sekar Galuh
BACKGROUND AND OBJECTIVE: Dragon fruit (Hylocereus spp.), apple (Malus sylvestris Mill.) and tomato (Solanum lycopersicum L.) are high potential sources of antioxidant compounds such as phenolics. The compounds have the capability of protecting cells and tissues against free radicals. Secondary metabolite produced by callus cell culture from plant organs also acts as a source of antioxidants. This study aimed to determine the optimal ratio of sucrose and 2,4-D in Murashige and Skoog (MS) medium for callus induction from different plant organ explants...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29022493/immunonutrition-before-esophagectomy-impact-on-immune-surveillance-mechanisms
#8
Marco Scarpa, Andromachi Kotsafti, Matteo Fassan, Melania Scarpa, Francesco Cavallin, Teresa Nardi, Eleonora Pinto, Rita Alfieri, Matteo Cagol, Marco Agostini, Massimo Rugge, Ignazio Castagliuolo, Carlo Castoro
Preoperative oral immunonutrition was demonstrated to improve immune response and to decrease the infection rate in patients with cancer. This study aimed to assess how immunonutrition could influence the immune cell response in the mucosal microenvironment of esophageal adenocarcinoma. Therefore, A prospective cohort of consecutive patients undergoing esophagectomy for esophageal adenocarcinoma was enrolled. A subgroup of them was given preoperative oral immunonutrition with Oral Impact® and was compared to those who received no preoperative supplementation...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29021961/dietary-practices-in-propionic-acidemia-a-european-survey
#9
A Daly, A Pinto, S Evans, M F Almeida, M Assoun, A Belanger-Quintana, S M Bernabei, S Bollhalder, D Cassiman, H Champion, H Chan, J Dalmau, F de Boer, C de Laet, A de Meyer, A Desloovere, A Dianin, M Dixon, K Dokoupil, S Dubois, F Eyskens, A Faria, I Fasan, E Favre, F Feillet, A Fekete, G Gallo, C Gingell, J Gribben, K Kaalund Hansen, N M Ter Horst, C Jankowski, R Janssen-Regelink, I Jones, C Jouault, G E Kahrs, I L Kok, A Kowalik, C Laguerre, S Le Verge, R Lilje, C Maddalon, D Mayr, U Meyer, A Micciche, U Och, M Robert, J C Rocha, H Rogozinski, C Rohde, K Ross, I Saruggia, A Schlune, K Singleton, E Sjoqvist, R Skeath, L H Stolen, A Terry, C Timmer, L Tomlinson, A Tooke, K Vande Kerckhove, E van Dam, T van den Hurk, L van der Ploeg, M van Driessche, M van Rijn, A van Wegberg, C Vasconcelos, H Vestergaard, I Vitoria, D Webster, F J White, L White, H Zweers, A MacDonald
BACKGROUND: The definitive dietary management of propionic acidaemia (PA) is unknown although natural protein restriction with adequate energy provision is of key importance. AIM: To describe European dietary practices in the management of patients with PA prior to the publication of the European PA guidelines. METHODS: This was a cross-sectional survey consisting of 27 questions about the dietary practices in PA patients circulated to European IMD dietitians and health professionals in 2014...
December 2017: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/29021891/a-good-sugar-d-mannose-suppresses-autoimmune-diabetes
#10
Yun-Bo Shi, Deling Yin
It is well known that too much sugar uptake causes many health problems, including diabetes and obesity (Lustig et al. in Nature 482:27-29, 2012). However, a team of researchers led by Dr. Wanjun Chen of the National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), USA, have recently shown that d-mannose, a naturally occurring C-2 epimer of glucose is likely beneficial to human health. Their studies have revealed that supraphysiological levels of d-mannose that are safely achievable via drinking-water supplementation can be preventive and therapeutic to experimental autoimmune diabetes and asthmatic lung inflammation (Zhang et al...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29020074/the-ability-of-algal-organic-matter-and-surface-runoff-to-promote-the-abundance-of-pathogenic-and-non-pathogenic-strains-of-vibrio-parahaemolyticus-in-long-island-sound-usa
#11
Jake D Thickman, Christopher J Gobler
Food safety is a major concern in the shellfish industry, as severe illness can result from consuming shellfish that have accumulated waterborne pathogens. Shellfish harvesting areas are typically monitored for indicator bacteria such as fecal coliforms that serve as proxies for enteric pathogens although these indicators have shown little relation to some naturally occurring pathogenic bacteria such as Vibrio parahaemolyticus. To examine the dynamics and ecology of pathogenic and non-pathogenic strains of V...
2017: PloS One
https://www.readbyqxmd.com/read/29019092/rapid-detection-of-human-norovirus-in-frozen-raspberries
#12
Maija Summa, Leena Maunula
Raspberries have lately caused several human norovirus (HuNoV) outbreaks in Europe. In this study, we developed and evaluated for HuNoV reverse transcription (RT)-PCR detection in frozen raspberries extraction methods that have equal sensitivity but are less time-consuming than widely used methods based on polyethylene glycol (PEG) precipitation and chloroform-butanol purification. One method was applied to stored frozen raspberries linked to previous HuNoV outbreaks and berries on sale. In the virus elution-based Method 1, sparkling water eluted viruses most efficiently from the berries...
October 10, 2017: Food and Environmental Virology
https://www.readbyqxmd.com/read/29018917/in-vitro-response-of-rumen-microbiota-to-the-antimethanogenic-red-macroalga-asparagopsis-taxiformis
#13
Lorenna Machado, Nigel Tomkins, Marie Magnusson, David J Midgley, Rocky de Nys, Carly P Rosewarne
The red macroalga Asparagopsis taxiformis has been shown to significantly decrease methane production by rumen microbial communities. This has been attributed to the bioaccumulation of halogenated methane analogues produced as algal secondary metabolites. The objective of this study was to evaluate the impact of A. taxiformis supplementation on the relative abundance of methanogens and microbial community structure during in vitro batch fermentation. Addition of A. taxiformis (2% organic matter) or the halogenated methane analogue bromoform (5 μM) reduced methane production by over 99% compared to a basal substrate-only control...
October 10, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/29018120/an-engineered-synthetic-pathway-for-discovering-nonnatural-nonribosomal-peptides-in-escherichia%C3%A2-coli
#14
Sara Cleto, Timothy K Lu
Peptides that are synthesized independently of the ribosome in plants, fungi, and bacteria can have clinically relevant anticancer, antihemochromatosis, and antiviral activities, among many other. Despite their natural origin, discovering new natural products is challenging, and there is a need to expand the chemical diversity that is accessible. In this work, we created a novel, compressed synthetic pathway for the heterologous expression and diversification of nonribosomal peptides (NRPs) based on homologs of siderophore pathways from Escherichia coli and Vibrio cholerae To enhance the likelihood of successful molecule production, we established a selective pressure via the iron-chelating properties of siderophores...
October 10, 2017: MBio
https://www.readbyqxmd.com/read/28993457/the-electron-transport-chain-sensitises-staphylococcus-aureus-and-enterococcus-faecalis-to-the-oxidative-burst
#15
Kimberley L Painter, Alex Hall, Kam Pou Ha, Andrew M Edwards
Small colony variants (SCVs) of Staphylococcus aureus typically lack a functional electron transport chain and cannot produce virulence factors such as leukocidins, hemolysins or the anti-oxidant staphyloxanthin. Despite this, SCVs are associated with persistent infections of the bloodstream, bones and prosthetic devices. The survival of SCVs in the host has been ascribed to intracellular residency, biofilm formation and resistance to antibiotics. However, the ability of SCVs to resist host defences is largely uncharacterised...
October 9, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28993436/efficacy-of-resveratrol-to-supplement-oral-nifedipine-treatment-in-pregnancy-induced-preeclampsia
#16
Jian Ding, Yan Kang, Yuqin Fan, Qi Chen
OBJECTIVE: Preeclampsia (PE) is a complication affecting pregnant women worldwide, which usually manifests as severe maternal hypertension. Resveratrol (RESV), a naturally existing polyphenol, is known to exhibit beneficial effects in cardiovascular disease including hypertension. We evaluated the outcome of treatment combining oral nifedipine (NIFE) and RESV against PE. DESIGN AND METHODS: Using a randomized group assignment, 400 PE patients were enrolled and received oral treatments of either NIFE + RESV or NIFE + placebo...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28990821/enrichment-broth-for-the-detection-of-campylobacter-jejuni-and-campylobacter-coli-in-fresh-produce-and-poultry
#17
Youmi Jo, Hye-Min Oh, Yohan Yoon, Sun-Young Lee, Ji-Hyoung Ha, Won-Il Kim, Hwang-Yong Kim, Sanghyun Han, Se-Ri Kim
Although campylobacteriosis caused by Campylobacter jejuni and Campylobacter coli has been increasingly reported worldwide owing to the consumption of contaminated poultry and fresh produce, the current detection protocols are not selective enough to inhibit unspecific microbes other than these pathogens. Five antibiotics were separately added to Bolton broth, and the survival rates of 18 Campylobacter spp. and 79 non-Campylobacter spp. were evaluated. The survival rate of the non-Campylobacter spp. was the lowest in Bolton broth with rifampin (6...
October 9, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28989916/use-of-progesterone-supplement-therapy-for-prevention-of-preterm-birth-review-of-literatures
#18
REVIEW
Suk-Joo Choi
Preterm birth (PTB) is one of the most common complications during pregnancy and it primarily accounts for neonatal mortality and numerous morbidities including long-term sequelae including cerebral palsy and developmental disability. The most effective treatment of PTB is prediction and prevention of its risks. Risk factors of PTB include history of PTB, short cervical length (CL), multiple pregnancies, ethnicity, smoking, uterine anomaly and history of curettage or cervical conization. Among these risk factors, history of PTB, and short CL are the most important predictive factors...
September 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28987917/an-evaluation-of-odor-repellent-effectiveness-in-prevention-of-wildlife-vehicle-collisions
#19
Michal Bíl, Richard Andrášik, Tomáš Bartonička, Zuzana Křivánková, Jiří Sedoník
Wildlife-vehicle collisions (WVC) amount to 11% of all registered traffic crashes in the Czech Republic causing, apart from numerous deaths and serious injuries to animals, property damage and injuries to car passengers. Odor repellents have the potential to lower the overall number of WVC and allow animals to cross roads at the same time. We tested the effectiveness of odor repellent preparation in prevention of WVC. 18 places were selected on the Czech road network where WVC were concentrated on the basis of traffic crash data...
October 4, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28987717/protective-effect-of-rumenic-acid-rich-cow-s-milk-against-colitis-is-associated-with-the-activation-of-nrf2-pathway-in-a-murine-model
#20
P Bergamo, E Cocca, A Monaco, V Cozzolino, F Boscaino, I Ferrandino, F Maurano, M Rossi
Dietary supplementation with pure cis9, trans11 isomer of Conjugated Linoleic Acid -known as Rumenic Acid (RA)- improves cytoprotective defenses downstream through the activation of nuclear factor-E2-related factor-2(Nrf2). This capability, when Rumenic Acid is consumed in the form of foods, is still unknown. The ability of standard (St) or cow milk naturally-enriched in RA (En) to activate Nrf2 pathway and its impact on dextran sodium sulfate (DSS)-induced colitis was comparatively evaluated. Activity of Nrf2 pathway was investigated in colonic tissue of BALB/c mice, receiving 4-week supplement with skimmed milk (SK), St or St reinforced with pure RA (RSt) providing increasing RA dose (0, 124 or 404mg RA/kg(-1) b...
October 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
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