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https://www.readbyqxmd.com/read/29679619/a-global-perspective-on-carotenoids-metabolism-biotechnology-and-benefits-for-nutrition-and-health
#1
REVIEW
Manuel Rodriguez Concepcion, Javier Avalos, M Luisa Bonet, Albert Boronat, Lourdes Gomez-Gomez, Damaso Hornero-Mendez, M Carmen Limon, Antonio J Meléndez-Martínez, Begoña Olmedilla-Alonso, Andreu Palou, Joan Ribot, Maria J Rodrigo, Lorenzo Zacarias, Changfu Zhu
Carotenoids are lipophilic isoprenoid compounds synthesized by all photosynthetic organisms and some non-photosynthetic bacteria and fungi. With some notable exceptions, animals (including humans) do not produce carotenoids de novo but take them in their diets. In photosynthetic systems carotenoids are essential for photoprotection against excess light and contribute to light harvesting, but perhaps they are best known for their properties as natural pigments in the yellow to red range. Carotenoids can be associated to fatty acids, sugars, proteins, or other compounds that can change their physical and chemical properties and influence their biological roles...
April 18, 2018: Progress in Lipid Research
https://www.readbyqxmd.com/read/29679298/future-of-treatment-for-nonalcoholic-steatohepatitis-can-the-use-of-safe-evidence-based-clinically-proven-supplements-provide-the-answer-to-the-unmet-need
#2
REVIEW
Yaron Ilan
The epidemic of nonalcoholic fatty liver disease (NAFLD) has created a real and unmet therapeutic need. The long regulatory pathway and the focus on selected subsets of patients with established and advanced disease are some of the current obstacles to providing effective treatment for the majority of NAFLD patients. The complexity of the disease pathogenesis, which involves multiple mechanisms, requires targeting of more than one pathway or a combination-based therapy. Although the drugs being developed may prevent progression to cirrhosis or may decrease negative liver outcomes, their effects on cardiometabolic health and cancer prevention remain unknown...
April 20, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29678720/a-completely-human-derived-biomaterial-mimicking-limbal-niche-platelet-rich-fibrin-gel
#3
Gamze Dereli Can, Özge Ekin Akdere, Mehmet Erol Can, Bahri Aydın, Nurullah Cagil, Menemşe Gümüşderelioğlu
Platelet-rich fibrin (PRF) is a natural biomaterial and has excellent biochemical and physical properties with a history of proven biocompatibility in the field of tissue engineering and regenerative medicine. Recent reports of fibrin-based matrices have offered new opportunities to apply PRF as a supplement for in vitro cell culture. Here, custom-modified human-derived PRF (HPRF) was produced via different centrifugation protocols, then, characterized by morphologically and chemically and utilized as a substrate and as a conditioned medium for limbal explant culture for the first time...
April 17, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29678719/carnosic-acid-attenuates-cartilage-degeneration-through-induction-of-heme-oxygenase-1-in-human-articular-chondrocytes
#4
Hiroyuki Ishitobi, Yohei Sanada, Yoshio Kato, Yasunari Ikuta, Sachi Shibata, Satoshi Yamasaki, Martin K Lotz, Kiminori Matsubara, Shigeru Miyaki, Nobuo Adachi
Osteoarthritis (OA) is common age-associated disease, and associated with joint pain, mobility limitations and compromised overall quality of life. OA treatment is currently limited to pain management and joint arthroplasty at end stage disease. Oxidative damage to cartilage extracellular matrix and cells is an important mechanism in joint aging and OA pathogenesis. Evidence from in vitro and in vivo models of OA suggests that pharmaceuticals and natural compounds with antioxidant properties reduce expression of mediators of OA pathogenesis and OA severity in animal models...
April 17, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29678666/biochemical-deficits-and-cognitive-decline-in-brain-aging-intervention-by-dietary-supplements
#5
REVIEW
Jit Poddar, Munmun Pradhan, Gargi Ganguly, Sasanka Chakrabarti
The aging of brain in the absence of neurodegenerative diseases, usually called non-pathological brain aging or normal cognitive aging, is characterized by an impairment of memory and cognitive functions. The underlying cellular and molecular changes in the aging brain that include oxidative damage, mitochondrial impairment, changes in glucose-energy metabolism and neuroinflammation have been reported widely from animal experiments and human studies. The cognitive deficit of non-pathological brain aging is the resultant of such inter-dependent and reinforcing molecular pathologies which have striking similarities with those operating in Alzheimer's disease which causes progressive, irreversible and a devastating form of dementia and cognitive decline in the elderly people...
April 17, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29677682/potential-benefits-and-phytotoxicity-of-bulk-and-nano-chitosan-on-the-growth-morphogenesis-physiology-and-micropropagation-of-capsicum-annuum
#6
Ghasem Asgari-Targhi, Alireza Iranbakhsh, Zahra Oraghi Ardebili
Concerning environmental issues of metal based-nanomaterials and increasing demand for nano-based products; various strategies have been employed to find eco-friendly natural nano-compounds, among which nano-polymer chitosan is mostly considered. Herein, the various aspects of the way in which bulk or nano-chitosan may modify growth, morphogenesis, micropropagation, and physiology of Capsicum annuum L. were considered. Culture medium was manipulated with different concentrations of bulk chitosan or synthesized chitosan/tripolyphosphate (TPP) nano-particle...
April 12, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29674964/botanical-provenance-of-traditional-medicines-from-carpathian-mountains-at-the-ukrainian-polish-border
#7
REVIEW
Weronika Kozlowska, Charles Wagner, Erin M Moore, Adam Matkowski, Slavko Komarnytsky
Plants were an essential part of foraging for food and health, and for centuries remained the only medicines available to people from the remote mountain regions. Their correct botanical provenance is an essential basis for understanding the ethnic cultures, as well as for chemical identification of the novel bioactive molecules with therapeutic effects. This work describes the use of herbal medicines in the Beskid mountain ranges located south of Krakow and Lviv, two influential medieval centers of apothecary tradition in the region...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29673977/epizootics-of-pseudomonas-anguilliseptica-among-cultured-seabream-sparus-aurata-populations-control-and-treatment-strategies
#8
Amr Fadel, Mahmoud Mabrok, Salah Aly
The present study was investigating the clinical pictures, prevalence, as well as the ecological conditions associated with Pseudomonas anguilliseptica outbreaks in four cultured seabream (Sparus aurata) farms at different localities in Egypt during the winter season of 2016. The phenotypic and genotypic patterns of pseudomonas isolates were investigated. The existence of intraspecific heterogeneity among different isolates was analyzed using Restriction fragment length polymorphism (RFLP) technique. Attempts on disease control using antibiogram or dietary supplement were also considered...
April 16, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29673137/herb-induced-liver-injuries-in-developing-nations-an-update
#9
REVIEW
Cecilia Nwadiuto Amadi, Orish Ebere Orisakwe
The last few decades have seen a rise in the use of herbal supplements, natural products, and traditional medicines. However, there are growing concerns related to the safety and toxicities of these medicines. These herbal medicines are associated with complications such as liver damage with a high incidence of mortalities and morbidities. Clinical manifestations range from asymptomatic cases with abnormal liver functions tests to sudden and severe liver failure necessitating liver transplantation. This work aimed to review the etiology, risk factors, diagnosis, clinical manifestations and selected clinical case reports of herbal hepatotoxicity in developing nations...
April 17, 2018: Toxics
https://www.readbyqxmd.com/read/29672963/butein-protects-the-nonalcoholic-fatty-liver-through-mitochondrial-reactive-oxygen-species-attenuation-in-rats
#10
Ghedeir M Alshammari, Aristatile Balakrishnan, Thirunavukkarasu Chinnasamy
One of the worldwide metabolic health dilemma is nonalcoholic fatty liver diseases (NAFLD). Researchers are searching effective drug to manage NAFLD patients. One of the best way to manage the metabolic imperfection is through natural principal isolated from different sources. Butein, a natural compound known to have numerous pharmacological application. In the current study we assessed the therapeutic effect of butein administration on liver function tests, oxidative stress, antioxidants, lipid abnormalities, serum inflammatory cytokines, and mitochondrial reactive oxygen species levels, in rats with methionine-choline deficient (MCD) diet induced NAFLD...
April 19, 2018: BioFactors
https://www.readbyqxmd.com/read/29672189/abrogation-of-hepatic-damage-induced-by-anticancer-drug-methotrexate-by-zobo-hibiscus-sabdariffa-extract-supplementation-via-targeting-oxidative-hepatotoxicity-in-rats
#11
Ademola C Famurewa, Abiola M Folawiyo, Michael A Epete, Emeka C Igwe, Paul I Okike, Ekenechukwu K Maduagwuna
Clinical use of methotrexate (MTX) in cancer chemotherapy is limited due to its side effects, notably associated with increased oxidative stress and hepatotoxicity. Zobo is an aqueous extract of Hibiscus sabdariffa known to contain natural antioxidants. The present study investigated the hepatoprotective effect of zobo drink (ZD) on MTX-induced oxidative stress and hepatotoxicity in rats. Rats randomized to control group received distilled water orally; MTX group received intraperitoneal (ip) injection of MTX (20 mg/kg) on day 11; ZD + MTX group was administered ZD (10 ml/kg) for 14 days and was injected with MTX on day 11...
April 19, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29670899/guava-leaf-extract-diminishes-hyperglycemia-and-oxidative-stress-prevents-%C3%AE-cell-death-inhibits-inflammation-and-regulates-nf-kb-signaling-pathway-in-stz-induced-diabetic-rats
#12
Muthukumaran Jayachandran, Ramachandran Vinayagam, Ranga Rao Ambati, Baojun Xu, Stephen Sum Man Chung
Traditional Chinese medication has been utilized by Chinese medical practitioners to treat the varied symptoms of diabetes mellitus (DM). Notably, guava leaf has been used to treat diabetes in Asia. Our present study has been designed to analyze the action of guava leaf extract (GLE) at the molecular level in treating DM. A low dose of streptozotocin (STZ) was used to induce experimental diabetes in animals. Rats were treated with GLE at different concentrations (100, 200, and 400 mg/kg b.w.). The standard drug glibenclamide (GB) (600  μ g/kg b...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29669035/effect-of-guanidinoacetic-acid-supplementation-on-live-performance-meat-quality-pectoral-myopathies-and-blood-parameters-of-male-broilers-fed-corn-based-diets-with-or-without-poultry-by-products
#13
H A Córdova-Noboa, E O Oviedo-Rondón, A H Sarsour, J Barnes, D Sapcota, D López, L Gross, M Rademacher-Heilshorn, U Braun
Creatine is a nitrogenous compound naturally occurring in animal tissues and is obtained from dietary animal protein or de novo synthesis from guanidinoacetic acid (GAA). The dietary supply of this semi-essential nutrient could be adversely compromised when feeding purely vegetable-based diets. The objective of this experiment was to evaluate the effects of GAA supplementation in broilers fed corn-based diets with or without the inclusion of poultry by-products (PBP) on live performance, carcass and cut up yields, meat quality, pectoral muscle myopathies, differential blood count, blood clinical chemistry, serum GAA and its metabolites...
April 13, 2018: Poultry Science
https://www.readbyqxmd.com/read/29666708/nonphotodynamic-roles-of-methylene-blue-display-of-distinct-antimycobacterial-and-anticandidal-mode-of-actions
#14
Rahul Pal, Moiz A Ansari, Venkata Saibabu, Shrayanee Das, Zeeshan Fatima, Saif Hameed
Significance of methylene blue (MB) in photodynamic therapy against microbes is well established. Previously, we have reported the antifungal potential of MB against Candida albicans . The present study attempts to identify additional antimicrobial effect of MB against another prevalent human pathogen, Mycobacterium tuberculosis (MTB). We explored that MB is efficiently inhibiting the growth of Mycobacterium at 15.62  μ g/ml albeit in bacteriostatic manner similar to its fungistatic nature. We uncovered additional cell surface phenotypes (colony morphology and cell sedimentation rate) which were impaired only in Mycobacterium ...
2018: Journal of Pathogens
https://www.readbyqxmd.com/read/29665931/-establishment-of-a-serum-free-culture-system-based-on-heparin-and-anti-cd16-antibody-for-expansion-of-human-cord-blood-nk-cells
#15
Qiao-Chu Wang, Liang Zhen
OBJECTIVE: To establish a novel method for ex vivo expansion of natural killer cells from human umbilical blood, so as to provide the basis for NK cell therapy. METHODS: Mononucleated cells from human umbilical blood were harvested and suspended in a serum-free medium containing 5% autologous plasma, recombinant human IL-15 (50 ng/ml) and hydrocortisone sodium succinate (5×10-8 mol/L) at a concentration of 1.5×106 /ml, then the cells were seeded into flasks pre-coated with heparin sodium (100 U/cm2 ) or/and anti-human CD16 antibody (1 µg/cm2 )...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29662333/the-prevalence-of-hypovitaminosis-d-and-its-associated-risk-factors-among-women-of-reproductive-age-in-saudi-arabia-a-systematic-review-and-meta-analysis
#16
REVIEW
Riyadh A Alzaheb
Vitamin D deficiency is currently a worldwide epidemic. Middle Eastern countries, including Saudi Arabia, have high vitamin D deficiency prevalence, most prominently among women, despite their plentiful year-round sunshine. Previous research investigating vitamin D status among Saudi women of reproductive age (15-49 years) is scarce, and no study has used a nationally representative sample, so this review quantified overall hypovitaminosis D prevalence among women in Saudi Arabia and explored the associated risk factors...
2018: Clinical Medicine Insights. Women's Health
https://www.readbyqxmd.com/read/29660879/chloromethane-formation-and-degradation-in-the-fern-phyllosphere
#17
Nicole Jaeger, Ludovic Besaury, Amelie Ninja Röhling, Fabien Koch, Anne-Marie Delort, Cyrielle Gasc, Markus Greule, Steffen Kolb, Thierry Nadalig, Pierre Peyret, Stéphane Vuilleumier, Pierre Amato, Françoise Bringel, Frank Keppler
Chloromethane (CH3 Cl) is the most abundant halogenated trace gas in the atmosphere. It plays an important role in natural stratospheric ozone destruction. Current estimates of the global CH3 Cl budget are approximate. The strength of the CH3 Cl global sink by microbial degradation in soils and plants is under discussion. Some plants, particularly ferns, have been identified as substantial emitters of CH3 Cl. Their ability to degrade CH3 Cl remains uncertain. In this study, we investigated the potential of leaves from 3 abundant ferns (Osmunda regalis, Cyathea cooperi, Dryopteris filix-mas) to produce and degrade CH3 Cl by measuring their production and consumption rates and their stable carbon and hydrogen isotope signatures...
April 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29658597/antitumoral-effect-of-ocoxin-a-natural-compound-containing-nutritional-supplement-in-small-cell-lung-cancer
#18
Elena Díaz-Rodríguez, Eduardo Sanz, Atanasio Pandiella
Lung cancer is the most frequently diagnosed neoplasia and represents the leading cause of cancer-related deaths worldwide. Due to this fact, efforts to improve patient survival through the introduction of novel therapies, as well as preventive actions, are urgently required. Considering this scenario, the antitumoral action of the composite formulation Ocoxin® oral solution (OOS), that contains several antitumoral compounds including antioxidants, was tested in small cell lung cancer (SCLC) in vitro and in vivo preclinical models...
April 16, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29657405/immunomodulatory-effects-of-probiotics-and-prilled-fat-supplementation-on-immune-genes-expression-and-lymphocyte-proliferation-of-transition-stage-karan-fries-cows
#19
Meeti Punetha, A K Roy, H M Ajithakumar, Irshad Ahmed Para, Deepanshu Gupta, Mahendra Singh, Jaya Bharati
Background and Aim: Probiotics are the living microorganism which when administered improves the digestion and health of the animal. Saccharomyces cerevisiae (SC) improves the humoral and innate immunity of the animal. Prilled fat is a hydrogenated palm oil triglyceride which has been reported to promote the release of cytokines from macrophages. The aim of the study was to evaluate the immunomodulatory effect of probiotic and prilled fat during transition stage in Karan Fries (KF) cows...
February 2018: Veterinary World
https://www.readbyqxmd.com/read/29655801/analysis-of-intragenic-ush2a-copy-number-variation-unveils-broad-spectrum-of-unique-and-recurrent-variants
#20
Christina A Austin-Tse, Diana L Mandelker, Andrea M Oza, Heather Mason-Suares, Heidi L Rehm, Sami S Amr
Given that all forms of Usher syndrome (USH) present with hearing loss in advance of retinal disease, the syndromic nature of the disorder is rarely appreciated when critical management decisions are being made. As a result, molecular diagnostics are crucial in guiding the management of USH patients. While 11 genes have been associated with USH, the USH2A gene is one of the largest contributors. Approximately 20% of suspected USH probands that undergo USH2A sequencing at our laboratory receive an inconclusive result due to the identification of a monoallelic disease-causing variant in USH2A...
April 12, 2018: European Journal of Medical Genetics
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