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https://www.readbyqxmd.com/read/29244779/omega-3-long-chain-polyunsaturated-fatty-acids-and-preeclampsia-trials-say-no-but-is-it-the-final-word
#1
REVIEW
Denis I Burchakov, Irina V Kuznetsova, Yuliya B Uspenskaya
Preeclampsia is a dangerous disorder of pregnancy, defined as hypertension with proteinuria. Its nature remains elusive, and measures of prevention and treatment are limited. Observational studies have suggested that preeclampsia is associated with low intake of omega-3 long-chain polyunsaturated fatty acids (LCPUFA). In recent decades, researchers studied LCPUFA supplementation as a measure to prevent preeclampsia. Most of these trials and later systematic reviews yielded negative results. However, these trials had several important limitations associated with heterogeneity and other issues...
December 15, 2017: Nutrients
https://www.readbyqxmd.com/read/29244104/-if-it-s-issues-to-do-with-nutrition%C3%A2-i-can-decide%C3%A2-gendered-decision-making-in-joining-community-based-child-nutrition-interventions-within-rural-coastal-kenya
#2
Kelly W Muraya, Caroline Jones, James A Berkley, Sassy Molyneux
Gender roles and relations play an important role in child health and nutritional status. While there is increasing recognition of the need to incorporate gender analysis in health planning and programme development, there has been relatively little attention paid to the gendered nature of child nutrition interventions. This qualitative study undertaken in rural Coastal Kenya aimed to explore the interaction between household gender relations and a community-based child nutrition programme, with a focus on household decision-making dynamics related to joining the intervention...
December 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29243819/novel-dietary-supplement-associationreduces-symptoms-in-endometriosis-patients
#3
Pietro Giulio Signorile, Rosa Viceconte, Alfonso Baldi
Endometriosis is characterized by disabling symptoms that afflict young women with severe physical discomfort, difficulty in relationship life, and infertility; however, the currently available therapeutic strategies are unsatisfactory. Goal of this research was to identify a new combination of natural active ingredients that, administered as dietary supplements, could have the effect of reducing inflammatory response in endometriosis patients, decreasing the symptoms the disease produces and its harmful effects on affected organs...
December 15, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29239791/in%C3%A2-vitro-flowering-in-oldenlandia-umbellata-l
#4
Shuvra Kanta Behera, Chandrasekaran Rajasekaran, S Payas, Devanand P Fulzele, C George Priya Doss, Ramamoorthy Siva
BACKGROUND: Oldenlandia umbellata L. (Indian madder) is an antique Ayurvedic Indian herb and a source of various anthraquinone derivatives. The red dye from its roots has been used in diverse applications since ancient times. OBJECTIVES: To establish reliable and effective protocols for in vitro flowering of O. umbellata. MATERIALS AND METHODS: For in vitro flowering, organogenic calli were subcultured onto Murashige and Skoog (MS) medium supplemented with various concentrations of Naphthalene acetic acid (NAA) (0...
November 24, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29239176/development-of-betalain-producing-callus-lines-from-colored-quinoa-varieties-chenopodium-quinoa-willd
#5
Paula Henarejos-Escudero, Berenice Guadarrama-Flores, M Alejandra Guerrero-Rubio, Luz Rayda Gómez-Pando, Francisco García-Carmona, Fernando Gandía-Herrero
Betalains are water soluble plant pigments of hydrophilic nature with promising bioactive potential. Among the scarce edible sources of betalains is the grain crop quinoa (Chenopodim quinoa Willd), with violet, red, and yellow grains being colored by these pigments. In this work callus cultures have been developed from differently colored plant varieties. Stable callus lines exhibited color and pigment production when maintained on Murashige and Skoog medium supplemented with the plant growth regulators 6-benzylaminopurine (8...
December 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29238193/in-vivo-evaluation-of-a-novel-nanocomposite-porous-3d-scaffold-in-a-rabbit-model-histological-analysis
#6
Saffanah Khuder Mahmood, Intan-Shameha Abdul Razak, Mustafa Saddam Ghaji, Loqman Mohamed Yusof, Zaid Khudhur Mahmood, Mohd Adha Bin P Rameli, Zuki Abu Bakar Zakaria
The healing of load-bearing segmental defects in long bones is a challenge due to the complex nature of the weight that affects the bone part and due to bending, shearing, axial, and torsional forces. An innovative porous 3D scaffolds implant of CaCO3 aragonite nanocomposite derived from cockle shell was advanced for substitute bone solely for load-bearing cases. The biomechanical characteristics of such materials were designed to withstand cortical bone strength. In promoting bone growth to the implant material, an ideal surface permeability was formed by means of freeze drying and by adding copolymers to the materials...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29228789/a-mechanistic-review-on-medicinal-plants-used-for-diabetes-mellitus-in-traditional-persian-medicine
#7
Fatemeh Farzaei, Mohammad Reza Morovati, Fatemeh Farjadmand, Mohammad Hosein Farzaei
Diabetes mellitus is the most common endocrine disorder and a major cause of morbidity and mortality. Traditional medicines worldwide suggest a wide range of natural remedies for the prevention and treatment of chronic disorders, including diabetes mellitus. This mechanistic review aims to highlight the significance of medicinal plants traditionally used as dietary supplements in Persian medicine in adjunct with restricted conventional drugs for the prevention and treatment of diabetes mellitus. Mounting evidence suggests that these natural agents perform their protective and therapeutic effect on diabetes mellitus via several cellular mechanisms, including regeneration of pancreatic β cell, limitation of glycogen degradation and gluconeogenesis, anti-inflammatory, immunoregulatory, antiapoptosis, antioxidative stress, as well as modulation of intracellular signaling transduction pathways...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/29228442/a-novel-boswellic-acids-delivery-form-casperome%C3%A2-in-the-management-of-musculoskeletal-disorders-a-review
#8
A Riva, P Allegrini, F Franceschi, S Togni, L Giacomelli, R Eggenhoffner
Standard pharmacological treatment of musculoskeletal conditions is often associated with relevant side effects. Botanical preparations endowed with a good tolerability profile, therefore, could have a role in the management of these disorders. Among different natural products, Boswellia serrata extracts have long been used for the treatment of musculoskeletal disorders, given their marked anti-inflammatory activity and their ability to promote tissue regeneration. However, standard preparations of Boswellia serrata show overall modest pharmacokinetic properties, a limitation which may ultimately lead to reduced efficacy...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29228000/an-in-vivo-assessment-of-the-cholesterol-lowering-efficacy-of-lactobacillus-plantarum-ecgc-13110402-in-normal-to-mildly-hypercholesterolaemic-adults
#9
Adele Costabile, Ivan Buttarazzi, Sofia Kolida, Sara Quercia, Jessica Baldini, Jonathan R Swann, Patrizia Brigidi, Glenn R Gibson
Coronary heart disease (CHD) is one of the major causes of death and disability in industrialised countries, with elevated blood cholesterol an established risk factor. Total plasma cholesterol reduction in populations suffering from primary hypercholesterolemia may lower CHD incidence. This study investigated the cholesterol reducing capacity of Lactobacillus plantarum ECGC 13110402, a strain selected for its high bile salt hydrolase activity, in 49 normal to mildly hypercholesterolaemic adults. Primary efficacy outcomes included effect on blood lipids (total cholesterol (TC), low density lipoproteins (LDL-C), high density lipoproteins (HDL-C) and triacylgycerides (TAG), inflammatory biomarkers and occurrence/severity of gastrointestinal side effects to establish safety and tolerance of the intervention...
2017: PloS One
https://www.readbyqxmd.com/read/29223475/insights-from-clinical-experience-in-treating-ivf-poor-responders
#10
REVIEW
Kelly J Gonda, Alice D Domar, Norbert Gleicher, Richard P Marrs
'Poor responders' is a term used to describe a subpopulation of IVF patients who do not respond well to ovarian stimulation with gonadotrophins. While there is no standard definition of a poor responder, these patients tend to be of advanced maternal age (≥40 years), have a history of poor ovarian response with conventional stimulation protocols, and/or have low ovarian reserve. Despite the heterogeneity of this patient group, there are characteristics and needs common to many poor responders that can be addressed through a holistic approach...
October 24, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29219824/thyrotoxic-periodic-paralysis-an-unusual-presentation-of-hyperthyroidism
#11
M Salih, C M J van Kinschot, R P Peeters, W W de Herder, E J J Duschek, J van der Linden, C van Noord
Thyrotoxic periodic paralysis (TPP) is a complication of hyperthyroidism among Asians, characterised by sudden onset of hypokalaemia and muscle paralysis. Several factors may contribute to a delay in diagnosis, including the subtlety of hyperthyroidism, the transient nature of the events and the rarity of this disease in the West. As life-threatening arrhythmias may occur during an attack, awareness among physicians is necessary for early recognition and treatment. Advances have been made in understanding the pathophysiological mechanism leading to hypokalaemia, which include recently identified mutations of the inwardly rectifying potassium channel Kir2...
October 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29219785/higher-absorption-of-vitamin-c-from-food-than-from-supplements-by-breastfeeding-mothers-at-early-stages-of-lactation
#12
Dorota Martysiak-Żurowska, Maciej Zagierski, Ewa Woś-Wasilewska, Agnieszka Szlagatys-Sidorkiewicz
The aim of the present study was to determine the effect of vitamin C supply in the diet of lactating women on vitamin C concentrations in human milk (n = 97) sampled at different stages of lactation. Vitamin C levels were measured by liquid chromatography. Dietary intake of vitamin C was determined based on 3-day food dairies kept by breastfeeding mothers. Maternal dietary intakes of vitamin C from natural sources on lactation day 90 (n = 18) were significantly higher than on lactation days 15 (n = 42) and 30 (n = 37)...
December 8, 2017: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/29219488/cancellation-mechanism-for-dark-matter-nucleon-interaction
#13
Christian Gross, Oleg Lebedev, Takashi Toma
We consider a simple Higgs portal dark-matter model, where the standard model is supplemented with a complex scalar whose imaginary part plays the role of weakly interacting massive particle dark matter (DM). We show that the direct DM detection cross section vanishes at the tree level and zero momentum transfer due to a cancellation by virtue of a softly broken symmetry. This cancellation is operative for any mediator masses. As a result, our electroweak-scale dark matter satisfies all of the phenomenological constraints quite naturally...
November 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29218888/identifying-natural-health-product-and-dietary-supplement-information-within-adverse-event-reporting-systems
#14
Vivekanand Sharma, Indra Neil Sarkar
Data on safety and efficacy issues associated with natural health products and dietary supplements (NHP&S) remains largely cloistered within domain specific databases or embedded within general biomedical data sources. A major challenge in leveraging analytic approaches on such data is due to the inefficient ability to retrieve relevant data, which includes a general lack of interoperability among related sources. This study developed a thesaurus of NHP&S ingredient terms that can be used by existing biomedical natural language processing (NLP) tools for extracting information of interest...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29215634/expansion-of-patient-derived-circulating-tumor-cells-from-liquid-biopsies-using-a-ctc-microfluidic-culture-device
#15
Bee Luan Khoo, Gianluca Grenci, Ying Bena Lim, Soo Chin Lee, Jongyoon Han, Chwee Teck Lim
The development of personalized cancer therapy depends on a robust system to monitor the patient's individual response to anticancer treatment. Anticancer drug efficacy has been tested on circulating tumor cells (CTCs) derived from patient blood samples after ex vivo expansion into CTC clusters. Current attempts to culture these primary cancer cells focus on long-term maintenance under growth factor supplements into cell lines, which usually takes >6 months and results in a CTC expansion efficiency of <20%...
January 2018: Nature Protocols
https://www.readbyqxmd.com/read/29214616/a-randomized-controlled-trial-evaluating-methylsulfonylmethane-versus-placebo-to-prevent-knee-pain-in-military-initial-entry-trainees
#16
David J Tennent, Christina M Hylden, Benjamin K Kocher, James K Aden, Anthony E Johnson
BACKGROUND: Methylsulfonylmethane (MSM) is a naturally occurring sulfur containing substance that has been shown to have anti-inflammatory and antioxidative properties. Previous studies using MSM as an oral supplement to improve pain in those patients with knee osteoarthritis have shown superiority compared to placebo. However, these studies are not translatable to active individuals performing high impact activities and have not evaluated MSM as a preventative measure. METHODS: A total of 180 subjects ranging in age from 18 to 40 years were enrolled...
October 2017: U.S. Army Medical Department Journal
https://www.readbyqxmd.com/read/29214487/effects-of-dietary-poly-%C3%AE-hydroxybutyrate-phb-on-microbiota-composition-and-the-mtor-signaling-pathway-in-the-intestines-of-litopenaeus-vannamei
#17
Yafei Duan, Yue Zhang, Hongbiao Dong, Yun Wang, Jiasong Zhang
Poly-β-hydroxybutyrate (PHB) is a natural polymer of the short chain fatty acid β-hydroxybutyrate, which acts as a microbial control agent. The mammalian target of the rapamycin (mTOR) signaling pathway plays a crucial role in intestine inflammation and epithelial morphogenesis. In this study, we examined the composition of intestine microbiota, and mTOR signaling-related gene expression in Pacific white shrimp Litopenaeus vannamei fed diets containing different levels of PHB: 0% (Control), 1% (PHB1), 3% (PHB3), and 5% (PHB5) (w/w) for 35 days...
December 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/29214185/administration-of-rhodiola-kirilowii-extracts-during-mouse-pregnancy-and-lactation-stimulates-innate-but-not-adaptive-immunity-of-the-offspring
#18
Sławomir Lewicki, Ewa Skopińska-Różewska, Aleksandra Brewczyńska, Robert Zdanowski
The use of antibiotics during pregnancy and lactation is associated with an increased risk of developmental disorders. One of the natural medicinal plants-Rhodiola kirilowii, widely used as an immunostimulant in adults-might be a good alternative to antibiotic treatment. The aim of present study was to assess whether daily oral administration of 20 mg/kg of Rhodiola kirilowii aqueous (RKW) or 50% hydroalcoholic (RKW-A) extracts affected hematological and immunological parameters of 6-week-old mouse progeny...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/29213315/comprehensive-characterization-of-toxicity-of-fermentative-metabolites-on-microbial-growth
#19
Brandon Wilbanks, Cong T Trinh
Background: Volatile carboxylic acids, alcohols, and esters are natural fermentative products, typically derived from anaerobic digestion. These metabolites have important functional roles to regulate cellular metabolisms and broad use as food supplements, flavors and fragrances, solvents, and fuels. Comprehensive characterization of toxic effects of these metabolites on microbial growth under similar conditions is very limited. Results: We characterized a comprehensive list of thirty-two short-chain carboxylic acids, alcohols, and esters on microbial growth of Escherichia coli MG1655 under anaerobic conditions...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29212261/cordycepin-stimulates-autophagy-in-macrophages-and-prevents-atherosclerotic-plaque-formation-in-apoe-mice
#20
Xin Li, Yue Zhou, Xue Zhang, Xiaoxue Cao, Chongming Wu, Peng Guo
Autophagy in macrophages plays a key role in the pathogenesis and progression of atherosclerosis and has become a potential therapeutic target. Here we show that cordycepin (Cpn), a natural derivative of adenosine, markedly reduced atherosclerotic plaque and ameliorated associated symptoms such as dyslipidemia, hyperglycemia and inflammation in ApoE-/- mice. Supplementation of Cpn dose-dependently inhibited oxLDL-elicited foam cell formation and modulated intracellular cholesterol homeostasis by inhibiting cholesterol uptake and promoting cholesterol efflux in RAW264...
November 7, 2017: Oncotarget
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