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https://www.readbyqxmd.com/read/29930742/multifactorial-analysis-of-the-stochastic-epigenetic-variability-in-cord-blood-confirmed-an-impact-of-common-behavioral-and-environmental-factors-but-not-of-in-vitro-conception
#1
D Gentilini, E Somigliana, L Pagliardini, E Rabellotti, P Garagnani, L Bernardinelli, E Papaleo, M Candiani, A M Di Blasio, P Viganò
Background: An increased incidence of imprint-associated disorders has been reported in babies born from assisted reproductive technology (ART). However, previous studies supporting an association between ART and an altered DNA methylation status of the conceived babies have been often conducted on a limited number of methylation sites and without correction for critical potential confounders. Moreover, all the previous studies focused on the identification of methylation changes shared among subjects while an evaluation of stochastic differences has never been conducted...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29930715/leinal-polypeptide-promotes-nk-cells-to-suppress-pca-survival-in-vitro
#2
Qun Rao, Huiping Zhang, Cuantai Zhang, Qianyuan Zhuang, Guanghui Du, Shaogang Wang, Zhangqun Ye, Yuan Chen
As an important component in the innate immune system, natural killer (NK) cells have been demonstrated to be clinically associated with prostate cancer (PCa) progression and castration resistance. Therefore, the development of novel agents that may enhance the cytotoxicity of NK cells possesses promising therapeutic applications. In the present study, leinal polypeptide (LP) solution was supplemented into a co-culture system of NK and PCa cells, as it was previously demonstrated that LP are able to activate NK cells, which kill PCa cells based on an MTT cell viability assay...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29929065/the-effect-of-leonardite-and-lignite-on-the-health-of-weaned-piglets
#3
Martina Trckova, Alena Lorencova, Vladimir Babak, Jiri Neca, Miroslav Ciganek
A three-week trial was conducted to evaluate the effects of leonardite and lignite, natural sources of humic substances, on selected indicators of health status of weaned piglets. A total of 45 weaned piglets were assigned to three dietary treatments: Control - basal diet without any medication; Leonardite or Lignite - diet supplemented with lignite or leonardite at a dose of 20 g/kg, respectively. Leonardite differed from lignite in the content of humic substances and minerals. Diarrhoea incidence and severity, growth performance, haematological and biochemical status, biomarkers of oxidative stress, serum fatty acid (FA) profile and faecal microbiota composition were monitored...
June 12, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29927502/flexible-enzymatic-activation-of-artificial-polyketide-extender-units-by-streptomyces-cinnamonensis-into-the-monensin-biosynthetic-pathway
#4
David Möller, Susanna Kushnir, Marius Grote, Ahmed Ismail-Ali, Kyra R M Koopmans, Fabio Calo, Sascha Heinrich, Bernd Diehl, Frank Schulz
Streptomyces cinnamonensis A495 is a variant of the monensin producer which instead of the native polyether antibiotic gives rise to antibiotic and anti-tumor shunt-product premonensin. Through the supplementation of the fermentation medium with suitable precursors, premonensin can be derivatized via the incorporation of new-to-nature extender units into the biosynthetic machinery. Polyketide extender units require activation, typically in form of coenzyme A thioesters. These are membrane impermeable and thus in the past an artificial mimic was employed...
June 21, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29926348/melatonin-treatment-suppresses-appetite-genes-and-improves-adipose-tissue-plasticity-in-diet-induced-obese-zebrafish
#5
G Montalbano, M Mania, F Abbate, M Navarra, M C Guerrera, R Laura, J A Vega, M Levanti, A Germanà
PURPOSE: Overweight and obesity are important risk factors for diabetes, cardiovascular diseases, and premature death in modern society. Recently, numerous natural and synthetic compounds have been tested in diet-induced obese animal models, to counteract obesity. Melatonin is a circadian hormone, produced by pineal gland and extra-pineal sources, involved in processes which have in common a rhythmic expression. In teleost, it can control energy balance by activating or inhibiting appetite-related peptides...
June 20, 2018: Endocrine
https://www.readbyqxmd.com/read/29924331/higher-plasma-selenium-concentrations-are-associated-with-increased-odds-of-prevalent-type-2-diabetes
#6
Lindsay N Kohler, Ana Florea, Connor P Kelley, Sherry Chow, Paul Hsu, Ken Batai, Kathylynn Saboda, Peter Lance, Elizabeth T Jacobs
Background: Selenium, an essential trace element, has been investigated as a potential cancer prevention agent. However, several studies have indicated that selenium supplementation may be associated with an increased risk of type 2 diabetes (T2D), although an equivocal relation of this nature requires confirmation. Objective: We examined the association between baseline plasma concentrations of selenium and the prevalence of T2D, as well as whether participant characteristics or intake of other antioxidant nutrients modified this relation...
June 19, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29923271/dissociations-of-cognitive-inhibition-response-inhibition-and-emotional-interference-voxelwise-ale-meta-analyses-of-fmri-studies
#7
Yuwen Hung, Schuyler L Gaillard, Pavel Yarmak, Marie Arsalidou
Inhibitory control is the stopping of a mental process with or without intention, conceptualized as mental suppression of competing information because of limited cognitive capacity. Inhibitory control dysfunction is a core characteristic of many major psychiatric disorders. Inhibition is generally thought to involve the prefrontal cortex; however, a single inhibitory mechanism is insufficient for interpreting the heterogeneous nature of human cognition. It remains unclear whether different dimensions of inhibitory processes-specifically cognitive inhibition, response inhibition, and emotional interference-rely on dissociated neural systems...
June 19, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29922118/cholesterol-lowering-effects-and-potential-mechanisms-of-chitooligosaccharide-capsules-in-hyperlipidemic-rats
#8
Yao Jiang, Chuhan Fu, Guihua Liu, Jiao Guo, Zhengquan Su
Background: Chitooligosaccharide (COS) has shown potential antihyperlipidemic activity in a few studies as a functional food. Method: We investigated the cholesterol-lowering effect and potential mechanisms of chitooligosaccharide capsules (COSTC) in male SD rats fed a high-fat diet. Results: COSTC could ameliorate serum lipid levels. Simultaneously, the cholesterol-lowering effect is probably attributed to its role in two pathways: upregulating the gene expression and activity of cholesterol 7α-hydroxylase (CYP7A1), liver X receptor alpha (LXRA), and peroxisome proliferation activated receptor-α (PPARα), which facilitates the conversion of cholesterol into bile acid; downregulating the gene expression and activity of enzymes including 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and sterol-responsive element binding protein-2 (SREBP2) and upregulating the low-density lipoprotein receptor (LDLR) to reduce the denovo synthesis of cholesterol...
2018: Food & Nutrition Research
https://www.readbyqxmd.com/read/29921833/antifungal-activity-and-synergism-with-azoles-of-polish-propolis
#9
Katarzyna Gucwa, Barbara Kusznierewicz, Sławomir Milewski, Patrick Van Dijck, Piotr Szweda
The aim of our work was to check if one of the products of natural origin, namely honey bee propolis, may be an alternative or supplement to currently used antifungal agents. The activity of 50 ethanolic extracts of propolis (EEPs), harvested in Polish apiaries, was tested on a group of 69 clinical isolates of C. albicans . Most of the EEPs showed satisfactory activity, with minimum fungicidal concentrations (MFC) mainly in the range of 0.08⁻1.25% ( v / v ). Eradication of biofilm from polystyrene microtitration plates in 50% (MBEC50 , Minimum Biofilm Eradication Concentration) required concentrations in the range of 0...
June 19, 2018: Pathogens
https://www.readbyqxmd.com/read/29916565/-care-related-intervention-in-rehabilitative-pneumology-pulmonary-rehabilitation-in-chronic-obstructive-broncopneumopathies-copd-can-benefit-from-a-multidisciplinary-approach
#10
Michele Vitacca, Dina Visca, Antonio Spanevello
OBJECTIVES: Chronic Obstructive Pulmonary Disease (COPD) is a common, preventable and treatable disease that is characterized by persistent respiratory symptoms and airflow limitation. Cardiovascular diseases, osteoporosis, depression/anxiety, musculoskeletal impairment and obstructive sleep apnea are frequent and important comorbidities in COPD, often under-diagnosed, and associated with poor health status and prognosis. METHODS: Pulmonary rehabilitation improves symptoms, quality of life, pulmonary function, and health care in patients with chronic respiratory disease...
February 2018: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29912757/dietary-interventions-in-liver-cirrhosis
#11
Chu Kion Yao, James Fung, Natural Hoi Sing Chu, Victoria Ping Yi Tan
Liver cirrhosis is associated with significant nutritional risks that often result in serious hepatic complications and poor survival rates. Diet is an important but underutilized aspect in the treatment modality of cirrhosis. Therefore, the aims of this review are to ascertain nutritional risks associated with its pathophysiology and to summarize existing evidence that support dietary recommendations for managing this patient population. Alterations in substrate utilization for energy production is a main feature of liver cirrhosis, resulting in increased catabolism of protein stores and a predisposition toward protein-energy malnutrition, even in the early stages of the disease...
June 16, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29910726/-n-palmitoylethanolamine-supplementation-for-long-lasting-low-dosed-morphine-antinociception
#12
Lorenzo Di Cesare Mannelli, Laura Micheli, Elena Lucarini, Carla Ghelardini
The facilitation of opioid medication is eliciting a nemetic problem since increasing overdose deaths involve prescription of opioid pain relievers. Chronic painful diseases require higher doses of opioids, progressively with the development of tolerance to the antinociceptive effect. Novel strategies for the maintenance of low dosed opioid effectiveness are necessary to relieve pain and decrease abuse, overdose, and side effects. N -Palmitoylethanolamine (PEA) is an endogenous compound able to preserve the homeostasis of the nervous system and to delay the development of morphine tolerance...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29910436/do-bodybuilders-use-evidence-based-nutrition-strategies-to-manipulate-physique
#13
Lachlan Mitchell, Daniel Hackett, Janelle Gifford, Frederico Estermann, Helen O'Connor
Competitive bodybuilders undergo strict dietary and training practices to achieve an extremely lean and muscular physique. The purpose of this study was to identify and describe different dietary strategies used by bodybuilders, their rationale, and the sources of information from which these strategies are gathered. In-depth interviews were conducted with seven experienced (10.4 ± 3.4 years bodybuilding experience), male, natural bodybuilders. Participants were asked about training, dietary and supplement practices, and information resources for bodybuilding strategies...
September 29, 2017: Sports
https://www.readbyqxmd.com/read/29908581/the-microbiome-in-dermatology
#14
Shenara Musthaq, Anna Mazuy, Jeannette Jakus
The skin supports a delicate ecosystem of microbial elements. Although the skin typically acts as a barrier, these microbes interact with the internal body environment and imbalances from the "healthy" state that have been linked to several dermatologic diseases. Understanding the changes in microbial flora in disease states allows for the potential to treat by restoring equilibrium. With the rising popularity of holistic and natural consumerism, prebiotics, probiotics, symbiotic, and other therapies are under study to find alternative treatments to these skin disorders through manipulation or supplementation of the microbiome...
May 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29908038/the-effect-of-dietary-corn-oil-and-fish-oil-supplementation-in-dogs-with-naturally-occurring-gingivitis
#15
Ana L Lourenço, Henriette E Booij-Vrieling, Carmen B Vossebeld, António Neves, Carlos Viegas, Ronald J Corbee
The aim of this randomized, double-blinded, placebo-controlled study was to evaluate if downregulation of the inflammatory response due to ingestion of high levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can slow down gingivitis development, and thus delay the progression of periodontal disease (PD) in dogs. To this aim, 44 client-owned adult dogs (>1 and <8 years old) with naturally occurring PD (stages 1 and 2) were submitted to a plaque, gingivitis and calculus scoring followed by a dental cleaning procedure and collection of blood samples...
June 16, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29907294/new-colorimetric-aptasensor-for-rapid-on-site-detection-of-campylobacter-jejuni-and-campylobacter-coli-in-chicken-carcass-samples
#16
Young-Ji Kim, Hong-Seok Kim, Jung-Whan Chon, Dong-Hyeon Kim, Ji-Yeon Hyeon, Kun-Ho Seo
Campylobacter is the most common cause of infectious intestinal disease, with nearly all cases caused by two species: C. jejuni and C. coli. We recently reported a gold nanoparticle-based two-stage aptasensing platform, which was improved in the present study for the rapid and on-site detection of both C. jejuni and C. coli in food samples. Compared to the previous platform, the improved platform yielded a more obvious colour change from red to purple due to the aggregation of gold nanoparticles, and does not require additional time or a pH optimization step for the aptamers to be adsorbed onto the gold nanoparticles...
October 31, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29905008/the-combined-effects-of-three-dimensional-cell-culture-and-natural-tissue-extract-on-neural-differentiation-of-p19-embryonal-carcinoma-stem-cells
#17
F Azizi, H R Jalil, Z Nasiri, J Moshtaghian, F Esmaeili, A Doostmohammadi, L Shabani, E Ebrahimie
Tissue engineering, as a novel transplantation therapy, aims to create biomaterial scaffolds resembling the extracellular matrix in order to regenerate the damaged tissues. Adding bioactive factors to the scaffold would improve cell-tissue interactions. In this study, the effect of chitosan poly vinyl alcohol nanofibers containing carbon nanotube scaffold with or without active bioglass (BG+ /BG- ), in combination with neonatal rat brain extract (NRBE) on cell viability, proliferation and neural differentiation of P19 embryonic carcinoma (EC) stem cells was investigated...
June 14, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29904796/use-of-satellite-remote-sensing-as-a-monitoring-tool-for-land-and-water-resources-development-activities-in-an-indian-tropical-site
#18
M D Behera, A K Gupta, S K Barik, P Das, R M Panda
With the availability of satellite data from free data domain, remote sensing has increasingly become a fast-hand tool for monitoring of land and water resources development activities with minimal cost and time. Here, we verified construction of check dams and implementation of plantation activities in two districts of Tripura state using Landsat and Sentinel-2 images for the years 2008 and 2016-2017, respectively. We applied spectral reflectance curves and index-based proxies to quantify these activities for two time periods...
June 15, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29904514/learning-science-communication-skills-using-improvisation-video-recordings-and-practice-practice-practice
#19
Nicholas M Ponzio, Janet Alder, Mary Nucci, David Dannenfelser, Holly Hilton, Nikolaos Linardopoulos, Carol Lutz
Doctoral students in science disciplines spend countless hours learning how to conduct cutting-edge research but very little time learning to communicate the nature and significance of their science to people outside their field. To narrow this disparity, we created an unusual course titled Communicating Science for doctoral science trainees at Rutgers University. Our goal was to help students develop an advanced ability to communicate their research clearly and accurately and to emphasize its value and significance to diverse audiences...
2018: Journal of Microbiology & Biology Education: JMBE
https://www.readbyqxmd.com/read/29903777/pancytopenia-in-an-adult-patient-with-thiamine-responsive-megaloblastic-anaemia
#20
Virginie Moulin, Francesco Grandoni, Julien Castioni, Henri Lu
Thiamine-responsive megaloblastic anaemia (TRMA) is a syndrome associated with megaloblastic anaemia, diabetes mellitus and sensorineural deafness, due to mutations in the SLC19A2 gene, which codes for a thiamine carrier protein. Oral thiamine supplementation is the main treatment. We report the case of a 25-year-old woman known for TRMA, who presented with pancytopenia (haemoglobin 7.6 g/dL, leucocytes 2.9×109 /L, thrombocytes 6×109 /L) revealed by dyspnoea. Investigations excluded coagulopathy, a recent viral infection, vitamin and iron deficiencies, and a malignant process...
June 14, 2018: BMJ Case Reports
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