keyword
https://read.qxmd.com/read/38421109/simplified-electrophysiological-approach-combining-a-point-of-care-nerve-conduction-device-and-an-electrocardiogram-produces-an-accurate-diagnosis-of-diabetic-polyneuropathy
#21
JOURNAL ARTICLE
Yusuke Hayashi, Tatsuhito Himeno, Yuka Shibata, Nobuhiro Hirai, Yuriko Asada-Yamada, Sachiko Sasajima, Emi Asano-Hayami, Mikio Motegi, Saeko Asano, Makoto Kato, Hiromi Nakai-Shimoda, Hiroya Tani, Emiri Miura-Yura, Yoshiaki Morishita, Masaki Kondo, Shin Tsunekawa, Takayuki Nakayama, Jiro Nakamura, Hideki Kamiya
AIMS/INTRODUCTION: This study aimed to investigate the diagnostic potential of two simplified tests, a point-of-care nerve conduction device (DPNCheck™) and a coefficient of variation of R-R intervals (CVR-R ), as an alternative to traditional nerve conduction studies for the diagnosis of diabetic polyneuropathy (DPN) in patients with diabetes. MATERIALS AND METHODS: Inpatients with type 1 or type 2 diabetes (n = 167) were enrolled...
February 29, 2024: Journal of Diabetes Investigation
https://read.qxmd.com/read/38410303/evaluating-the-diagnostic-potential-of-serum-vascular-endothelial-growth-factor-and-adiponectin-in-diabetic-peripheral-neuropathy
#22
JOURNAL ARTICLE
Palani Selvam Mohanraj, Arani Das, Aniruddha Sen, Amit Ranjan, Vinoth Rajendran, Anupriya Velu, U Venkatesh
INTRODUCTION: Diabetic peripheral neuropathy (DPN) presents a formidable health challenge in type 2 diabetes mellitus (T2DM) patients. This study in eastern Uttar Pradesh aims to assess the roles of vascular endothelial growth factor (VEGF) and adiponectin in DPN, recognizing the crucial need for understanding its molecular underpinnings for enhanced diagnosis and management. METHODS: In a cross-sectional study analyzing clinical and biochemical data, 86 individuals aged 35 to 65 years were examined, including 43 with neuropathy and 43 without...
January 2024: Curēus
https://read.qxmd.com/read/38408489/does-the-relationship-of-the-autonomic-symptoms-questionnaire-compass-31-with-cardiovascular-autonomic-tests-differ-between-type-1-and-type-2-diabetes-mellitus
#23
JOURNAL ARTICLE
Ilenia D'Ippolito, Marika Menduni, Cinzia D'Amato, Aikaterini Andreadi, Davide Lauro, Vincenza Spallone
BACKGROUND: The aim was to investigate if autonomic symptoms questionnaire Composite Autonomic Symptom Score (COMPASS) 31 has different association with cardiovascular autonomic neuropathy (CAN) and diagnostic performance between type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). METHODS: Seventy-nine participants with T1DM and 140 with T2DM completed COMPASS 31 before cardiovascular reflex tests (CARTs) for CAN, and assessment of symptoms, signs, vibration, and thermal perception thresholds for diabetic polyneuropathy (DPN) diagnosis...
February 26, 2024: Diabetes & Metabolism Journal
https://read.qxmd.com/read/38397022/unearthing-a-cryptic-biosynthetic-gene-cluster-for-the-piperazic-acid-bearing-depsipeptide-diperamycin-in-the-ant-dweller-streptomyces-sp-cs113
#24
JOURNAL ARTICLE
Coral García-Gutiérrez, Ignacio Pérez-Victoria, Ignacio Montero, Jorge Fernández-De la Hoz, Mónica G Malmierca, Jesús Martín, José A Salas, Carlos Olano, Fernando Reyes, Carmen Méndez
Piperazic acid is a cyclic nonproteinogenic amino acid that contains a hydrazine N-N bond formed by a piperazate synthase (KtzT-like). This amino acid, found in bioactive natural products synthesized by non-ribosomal peptide synthetases (NRPSs), confers conformational constraint to peptides, an important feature for their biological activities. Genome mining of Streptomyces strains has been revealed as a strategy to identify biosynthetic gene clusters (BGCs) for potentially active compounds. Moreover, the isolation of new strains from underexplored habitats or associated with other organisms has allowed to uncover new BGCs for unknown compounds...
February 16, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38394307/the-accuracy-of-10-g-monofilament-use-for-clinical-screening-of-diabetes-peripheral-neuropathy-among-indian-population
#25
JOURNAL ARTICLE
Animesh Hazari, Vinaytosh Mishra, Praveen Kumar, Arun Maiya
OBJECTIVE: The purpose of this study was to test the diagnostic accuracy of the 10g monofilament to screen for diabetic peripheral neuropathy (DPN) in India. The study further assessed the effect of physical activity, footwear use, and occupation on the outcome. METHODS: Non-probabilistic purposive sampling was used to recruit patients with T2DM to assess the diagnostic utility of the 10 g monofilament. 160 participants were recruited divided into 4 groups. Each group consisted of 40 participants with 20 under each category described as "Physical Worker Vs Non- physical worker" (n = 40), "Barefoot Vs Footwear" (n = 40), "Use of Slipper at Home Vs No-slippers use at home" (n = 40), "Agriculture Vs Non- agriculture" (n = 40)...
2024: PloS One
https://read.qxmd.com/read/38390212/exploring-the-molecular-mechanism-of-xuebifang-in-the-treatment-of-diabetic-peripheral-neuropathy-based-on-bioinformatics-and-network-pharmacology
#26
JOURNAL ARTICLE
Faquan Hu, Jiaran Lin, Liyuan Xiong, Zhengpin Li, Wen-Ke Liu, Yu-Jiao Zheng
BACKGROUND: Xuebifang (XBF), a potent Chinese herbal formula, has been employed in managing diabetic peripheral neuropathy (DPN). Nevertheless, the precise mechanism of its action remains enigmatic. PURPOSE: The primary objective of this investigation is to employ a bioinformatics-driven approach combined with network pharmacology to comprehensively explore the therapeutic mechanism of XBF in the context of DPN. STUDY DESIGN AND METHODS: The active chemicals and their respective targets of XBF were sourced from the TCMSP and BATMAN databases...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38374490/effect-and-safety-of-herbal-medicine-foot-baths-in-patients-with-diabetic-peripheral-neuropathy-a-multicenter-double-blind-randomized-controlled-trial
#27
RANDOMIZED CONTROLLED TRIAL
Hao-Yue Huang, Yu-Ping Lin, Hua Wei, Yu Fu, Yue-Hong Zhou, Zhao-Hui Fang, Xiao-Tang Qiu, Mei Wang, Qing-Bo Li, Shan-Shan Li, Shi-Dong Wang, Fang Dai, Zhen-Jie Liu, Ling Zhao, Jian-Xuan Wen, Li-Yan Wu, Hui-Yan Zeng, Jin-Ming Zhang, Qi-Yun Lu, Liu He, Wei Song, Lu Sun, Lu-Lu Luo, Jia-Li He, Wen-Wen Xie, Qing-Shun Liang, Yuan Huang, Sheng-Ling Zhu, Jie-Er Long, Zhi-Juan Gao, Ze-Huai Wen, Chun-Ji Li, Wen-Wei Ouyang, Geng Li, Ming-Hui Wu, An-Xiang Li, Jin-Zhu Huang, Sanjoy K Paul, Xian-Yu Tang, Guan-Jie Fan
OBJECTIVE: To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction (TW) in treating patients with diabetic peripheral neuropathy (DPN). METHODS: It is a multicenter double-blinded randomized controlled trial. Participants with DPN were recruited between November 18, 2016 and May 30, 2018 from 8 hospitals in China. All patients received basic treatments for glycemic management. Patients received foot baths with TW herbal granules either 66.9 g (intervention group) or 6...
March 2024: Chinese Journal of Integrative Medicine
https://read.qxmd.com/read/38370359/vglut2-and-app-family-unraveling-the-neurobiochemical-mechanisms-of-neurostimulation-therapy-to-stz-induced-diabetes-and-neuropathy
#28
JOURNAL ARTICLE
Yitong Zhang, Chenxuan Wu, Wenqi Jiang, Yan Cao, Dongtai Chen
Diabetic Peripheral Neuropathy (DPN) poses an escalating threat to public health, profoundly impacting well-being and quality of life. Despite its rising prevalence, the pathogenesis of DPN remains enigmatic, and existing clinical interventions fall short of achieving meaningful reversals of the condition. Notably, neurostimulation techniques have shown promising efficacy in alleviating DPN symptoms, underscoring the imperative to elucidate the neurobiochemical mechanisms underlying DPN. This study employs an integrated multi-omics approach to explore DPN and its response to neurostimulation therapy...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38367309/progression-of-axonal-excitability-abnormalities-with-increasing-clinical-severity-of-diabetic-peripheral-neuropathy
#29
JOURNAL ARTICLE
Roshan Dhanapalaratnam, Tushar Issar, Ann M Poynten, Kerry-Lee Milner, Natalie C G Kwai, Arun V Krishnan
OBJECTIVE: Diabetic peripheral neuropathy (DPN) is a frequent complication for persons with type 2 diabetes. Previous studies have failed to demonstrate any significant impact of treatment for DPN. The present study assessed the role of axonal ion channel dysfunction in DPN and explored the hypothesis that there may be a progressive change in ion channel abnormalities that varied with disease stage. METHODS: Neurophysiological studies were conducted using axonal excitability techniques, a clinical method of assessing ion channel dysfunction...
February 9, 2024: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://read.qxmd.com/read/38367144/association-between-phase-angle-and-diabetic-peripheral-neuropathy-in-type-2-diabetes-patients
#30
JOURNAL ARTICLE
Junli Zhang, Zhenghui Xu, Yu Fu, Lu Chen
BACKGROUND: Diabetic peripheral neuropathy (DPN), the very prevalent microvascular complication of type 2 diabetes mellitus (T2DM), severely threatens the quality of life of diabetic patients. Thus, prevention of DPN is extremely important for public health, and the identification of potential biomarkers may help with early prevention. Our work determined the association between phase angles (PhAs) and the risk of DPN in T2DM patients. MATERIALS AND METHODS: This cross-sectional study recruited 697 T2DM patients from the Third Affiliated Hospital of Soochow University...
February 17, 2024: Endocrine
https://read.qxmd.com/read/38364910/vitamin-d-deficiency-increases-the-risk-of-diabetic-peripheral-neuropathy-in-elderly-type-2-diabetes-mellitus-patients-by-predominantly-increasing-large-fiber-lesions
#31
JOURNAL ARTICLE
Sijia Fei, Jingwen Fan, Jiaming Cao, Huan Chen, Xiaoxia Wang, Qi Pan
AIMS: This study explores the link between Vitamin D deficiency (VDD) and diabetic peripheral neuropathy (DPN) in elderly type 2 diabetes mellitus (T2DM) patients. METHODS: Involving 257 elderly T2DM patients, the study utilized propensity score matching to balance age, sex, and diabetes duration. VDD was defined as serum 25-hydroxyvitamin D [25(OH)D] levels below 20 ng/ml. Large nerve fiber lesions were evaluated by electromyogram, while small nerve fiber lesions were assessed by measuring skin conductance...
February 14, 2024: Diabetes Research and Clinical Practice
https://read.qxmd.com/read/38360684/electroacupuncture-efficacy-in-diabetic-polyneuropathy-study-protocol-for-a-double-blinded-randomized-controlled-multicenter-clinical-trial
#32
JOURNAL ARTICLE
María Fernanda Pérez Hernández, Alejandra Calderón Vallejo, Sergio de Jesús Aguilar Castillo, Daniel Cuauhtémoc Gómez Jiménez, Eduardo Rodríguez Guerrero, Fátima Aguilar Morales, Macedonia Guadalupe Moreno Tovar, Miguel Alfredo Zurita Muñóz, Antonio Eduardo Bautista Cortéz, Claudia Camelia Calzada Mendoza, Mónica Ascención De Nova Ocampo, Juan Manuel Ordóñez Rodríguez, Mónica Luz Gómez Esquivel, Alberto García Méndez, Octavio Flores Gil, Víctor Manuel Macías Zaragoza, Gabriela Yanet Cortés Moreno, Citlaltepetl Salinas Lara, Germán Velázquez García, Héctor Iván Saldivar Cerón, Lucia Monserrat Pérez Navarro, Laura Ávila Jiménez, Jaime Héctor Gómez Zamudio, Margarita Díaz Flores, Miguel Cruz López, María Esther Ocharan Hernández, José de Jesús Peralta Romero
BACKGROUND: Diabetic peripheral neuropathy (DPN) is the most common complication of type 2 diabetes mellitus (T2DM); its diagnosis and treatment are based on symptomatic improvement. However, as pharmacological therapy causes multiple adverse effects, the implementation of acupunctural techniques, such as electroacupuncture (EA) has been suggested as an alternative treatment. Nonetheless, there is a lack of scientific evidence, and its mechanisms are still unclear. We present the design and methodology of a new clinical randomized trial, that investigates the effectiveness of EA for the treatment of DPN...
February 15, 2024: BMC complementary medicine and therapies
https://read.qxmd.com/read/38358067/integrated-genetic-analysis-of-diabetic-complications-bioinformatics-insights-into-foot-ulcers-neuropathy-and-peripheral-artery-disease
#33
JOURNAL ARTICLE
Jiaru Liang, Xiaoyang Gong, Xuyang Hu, Chong You, Jiaqi Zhou, Yuling Gao, Junwei Zong, Yong Liu
Diabetic foot ulcers (DFU), diabetic peripheral neuropathy (DPN) and peripheral arterial disease (PAD) are common complications of diabetes mellitus, while diabetic peripheral neuropathy and peripheral arterial disease contribute to the pathogenesis of diabetic foot ulcers, and the pathogenic mechanisms between these three diseases still need further investigation. The keywords 'diabetic foot ulcer', 'diabetic peripheral neuropathy' and 'atherosclerosis' were used to search for related gene sets in the GEO database...
February 2024: International Wound Journal
https://read.qxmd.com/read/38352324/macrophages-protect-against-sensory-axon-degeneration-in-diabetic-neuropathy
#34
Sara Hakim, Aakanksha Jain, Veselina Petrova, Jonathan Indajang, Riki Kawaguchi, Qing Wang, Elif Sude Duran, Drew Nelson, Stuart S Adamson, Caitlin Greene, Clifford J Woolf
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes, causing sensory loss and debilitating neuropathic pain 1,2 . Although the onset and progression of DPN have been linked with dyslipidemia and hyperglycemia 3 , the contribution of inflammation in the pathogenesis of DPN has not been investigated. Here, we use a High Fat High Fructose Diet (HFHFD) to model DPN and the diabetic metabolic syndrome in mice. Diabetic mice develop persistent heat hypoalgesia after three months, but a reduction in epidermal skin innervation only manifests at 6 months...
January 30, 2024: bioRxiv
https://read.qxmd.com/read/38349953/serum-neurofilament-light-chain-a-potential-biomarker-for-polyneuropathy-in-type-2-diabetes
#35
JOURNAL ARTICLE
Laura L Määttä, Signe T Andersen, Tina Parkner, Claus V B Hviid, Lasse Bjerg, Mustafa A Kural, Morten Charles, Esben Søndergaard, Annelli Sandbæk, Hatice Tankisi, Daniel R Witte, Troels S Jensen
AIMS: To investigate the relationship between neurofilament light chain (NfL) and the presence and severity of diabetic polyneuropathy (DPN). METHODS: We performed cross-sectional analysis of data from 178 participants of the ADDITION-Denmark cohort of people with screen-detected type 2 diabetes and 32 healthy controls. Biobank serum samples were analyzed for NfL using single-molecule array. DPN was defined by Toronto criteria for confirmed DPN. Original and axonal nerve conduction study (NCS) sum z-scores were used as indicators of the severity of DPN and peripheral nerve damage...
November 2023: Diabetes Research and Clinical Practice
https://read.qxmd.com/read/38347769/prevalence-and-predictors-of-diabetic-peripheral-neuropathy-in-newly-diagnosed-type-2-diabetes-mellitus-patients
#36
JOURNAL ARTICLE
Pooja Jadhao, Jayshree Swain, Srijit Das, Swayamsidha Mangaraj, Surapaneni Lakshmi Sravya
AIM: The present study aimed to determine the prevalence and predictors of DPN in newly diagnosed T2DM patients. BACKGROUND: Diabetic Peripheral Neuropathy (DPN) is the most common and debilitating complication of Type 2 Diabetes Mellitus (T2DM). METHODS: Newly diagnosed T2DM patients visiting the outpatient department were recruited. Detailed demographic parameters, histories, physical examinations, and biochemical investigations were carried out...
February 12, 2024: Current Diabetes Reviews
https://read.qxmd.com/read/38346295/association-between-macro-and-microvascular-damage-and-sarcopenia-index-in-individuals-with-type-2-diabetes-mellitus
#37
JOURNAL ARTICLE
Hui Xu, Qun-Yan Xiang, Jun-Kun Zhan, Yi Wang, Yan-Jiao Wang, Shuang Li, You-Shuo Liu
Sarcopenia was recently reported to be relevant to an increased macro-and microvascular disease risk. Sarcopenia index (SI) has been identified as a surrogate marker for sarcopenia. The aim of the present study was to investigate the association between macro- and microvascular disease and SI in patients with T2DM. A total of 783 patients with T2DM were enrolled in this cross-sectional study. The SI was calculated by (serum creatinine [mg/dL]/cystatin C [mg/L]) ×100. The subjects were divided into three groups according to SI tertiles: T1 (41...
February 12, 2024: Applied Physiology Nutrition and Metabolism
https://read.qxmd.com/read/38337315/a-theoretical-investigation-of-the-polyaddition-of-an-ab-2-a-2-b-4-monomer-mixture
#38
JOURNAL ARTICLE
Sergei V Karpov, Artem Iakunkov, Dmitry A Chernyaev, Vladimir G Kurbatov, Georgiy V Malkov, Elmira R Badamshina
Hyperbranched polymers (HBPs) are widely applied nowadays as functional materials for biomedicine needs, nonlinear optics, organic semiconductors, etc. One of the effective and promising ways to synthesize HBPs is a polyaddition of AB2 +A2 +B4 monomers that is generated in the A2 +CB2 , AA'+B3 , A2 +B'B2 , and A2 +C2 +B3 systems or using other approaches. It is clear that all the foundational features of HBPs that are manufactured by a polyaddition reaction are defined by the component composition of the monomer mixture...
February 3, 2024: Polymers
https://read.qxmd.com/read/38333576/expert-consensus-guidelines-for-community-pharmacists-in-the-management-of-diabetic-peripheral-neuropathy-with-a-combination-of-neurotropic-b-vitamins
#39
REVIEW
Thanompong Sathienluckana, Sirinoot Palapinyo, Kitiyot Yotsombut, Ekgaluck Wanothayaroj, Pasiri Sithinamsuwan, Naeti Suksomboon
This consensus guidance is for community pharmacists in diabetic peripheral neuropathy (DPN) management with a combination of neurotropic B vitamins. A multidisciplinary team including endocrinology, neurology, and pharmacy from Thailand discussed and aligned the practical scheme of DPN management in the community pharmacy setting, using the literature review and having face-to-face meeting. Five major statements have been endorsed as consensus recommendations for DPN care with strong acknowledgment. The aims of DPN management included reducing symptoms and the risk of complications, minimising adverse reactions from treatment regimens, and improving patients' knowledge and adherence to the treatment strategies...
2024: Journal of Pharmaceutical Policy and Practice
https://read.qxmd.com/read/38328975/effect-of-lower-extremity-nerve-decompression-in-patients-with-painful-diabetic-peripheral-neuropathy-the-dnnd-randomized-observation-group-and-placebo-surgery-controlled-clinical-trial
#40
JOURNAL ARTICLE
Shai M Rozen, Gil I Wolfe, Steven Vernino, Philip Raskin, Linda S Hynan, Kathleen Wyne, Rita Fulmer, Geetha Pandian, Shiv K Sharma, Ahneesh J Mohanty, Cristina V Sanchez, Austin Hembd, April Gorman
OBJECTIVE: Evaluate the effect of nerve decompression on pain in patients with lower extremity painful Diabetic Peripheral Neuropathy (DPN). SUMMARY BACKGROUND DATA: Currently, no treatment provides lasting relief for patients with DPN. Benefits of nerve decompression remain inconclusive. METHODS: This double-blinded, observation- and same-patient sham surgery-controlled randomized trial enrolled patients aged 18-80 years with lower extremity painful DPN who failed one-year of medical treatment...
February 8, 2024: Annals of Surgery
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