keyword
MENU ▼
Read by QxMD icon Read
search

DPN

keyword
https://www.readbyqxmd.com/read/29753178/the-management-of-dorsal-peroneal-nerve-compression-in-the-midfoot
#1
Baljinder Singh Dhinsa, Laila Hussain, Sam Singh
The foot and ankle specialist will frequently encounter patients with dorsal midfoot pain in clinic. In the presence of midfoot pain and/or paraesthesia, nerve entrapment must be considered. The authors report the outcome of a case series of patients who underwent surgical release of the DPN. Between 2011-2017, a single surgeon operated on seven patients with a diagnosis of DPN entrapment. A retrospective review of the patient's clinical notes was performed, including the operative findings. The average age at presentation was 47 years (range, 31-70 years), and the left foot was affected in four cases...
December 28, 2017: Foot
https://www.readbyqxmd.com/read/29750001/effect-of-combined-dyslipidemia-and-hyperglycemia-on-diabetic-peripheral-neuropathy-in-alloxan-induced-diabetic-wbn-kob-rats
#2
Kiyokazu Ozaki, Yui Terayama, Tetsuro Matsuura, Isao Narama
Clinical and experimental research have suggested that dyslipidemia aggravates diabetic peripheral neuropathy (DPN). However, whether dyslipidemia is a risk factor for DPN remains unclear. To investigate the effect of dyslipidemia on DPN, morphological features of peripheral nerves were analyzed in diabetic rats treated with a high-fat diet (HFD). Male rats were divided into four groups: nondiabetic rats (N), alloxan-induced diabetic rats (AL), diabetic rats treated with an HFD (AH), and nondiabetic rats treated with an HFD (HF)...
April 2018: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/29749025/photobiomodulation-induces-antinociception-recovers-structural-aspects-and-regulates-mitochondrial-homeostasis-in-peripheral-nerve-of-diabetic-mice
#3
Victória Regina da Silva de Oliveira, Diego Pulzatto Cury, Laura Basílio Yamashita, Marcos Vinicius Esteca, Ii-Sei Watanabe, Yoko Fee Bergmann, Elaine Flamia Toniolo, Camila Squarzoni Dale
Diabetic Peripheral Neuropathy (DPN) is a nervous disorder caused by diabetes mellitus, affecting about 50% of patients in clinical medicine. Chronic pain is one of the major and most unpleasant symptoms developed by those patients, and conventional available treatments for the neuropathy, including the associated pain, are still unsatisfactory and benefit only a small number of patients. Photobiomodulation (PBM) has been gaining clinical acceptance once it is able to promote early nerve regeneration resulting in significant improvement peripheral nerves disabilities...
May 11, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29739451/reflex-erection-in-the-rat-reciprocal-interplay-between-hemodynamic-and-somatic-events
#4
Alexander Andreev-Andrievskiy, Evgeniia Lagereva, Anfisa Popova
BACKGROUND: Penile erection is a complex reflex under spinal control and modulated by the brain. The hemodynamic events under autonomic control and the perineal muscles somatic activity are interconnected during the reflex erection at the spinal level, however if the afferent feedback on the corpus cavernosum pressure during an erection affects the somatic activity (perineal muscles contractions) and vice versa is not known. This study was aimed to test this hypothesis using a rat model...
May 8, 2018: BMC Urology
https://www.readbyqxmd.com/read/29738062/-ultrasound-guided-penile-nerve-block-for-pediatric-hypospadias-surgery
#5
Neşe Türkyılmaz, Yavuz Gürkan, Sevim Cesur, Alparslan Kuş, Mine Solak
An ultrasound-guided dorsal penile nerve (DPN) block was performed for postoperative analgesia in a 6-year-old, 19 kg, American Society of Anesthesiologists class II patient undergoing hypospadias surgery. The block was applied following the induction of general anesthesia. Anesthesia maintenance was provided with sevoflurane 2% in a 1:2 ratio of oxygen and nitrous oxide. The DPN block was performed using 0.2 mL/kg of 0.25% bupivacaine. Almost 24 hours of analgesia was provided following surgery.
April 2018: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/29737807/association-of-vitamin-d-deficiency-with-diabetic-peripheral-neuropathy-and-diabetic-nephropathy-in-tianjin-china
#6
Leping Fan, Yue Zhang, Jie Zhu, Yixuan Song, Jingna Lin
BACKGROUND AND OBJECTIVES: To evaluate the association of vitamin D deficiency with type 2 diabetic peripheral neuropathy (DPN) and diabetic nephropathy (DN). METHODS AND STUDY DESIGN: A total of 287 type 2 diabetic patients were categorized in two ways, and each divided into two groups: DPN (n=164) and non-DPN (NDPN) groups (n=123); and DN (n=148) and non-DN (NDN) groups (n=139). Enzyme-linked immunosorbent assay was used to measure the 25-hydroxy vitamin D [25(OH)D3] level...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29736880/comparison-of-peripheral-nerve-protection-between-insulin-based-glucose-control-and-alpha-lipoic-acid-ala-in-the-streptozotocin-stz-induced-diabetic-rat
#7
Kyung Ae Lee, Na Young Lee, Tae Sun Park, Heung Yong Jin
Strict glucose control is a well-proven therapeutic approach for peripheral neuropathies in patients with diabetes. Alpha lipoic acid (ALA) has also been accepted as a therapeutic agent for diabetic peripheral neuropathy (DPN) in the respect of pathogenesis. However, the potential of ALA as a treatment for DPN in comparison to that of glucose control is unclear. In this study, we compared the neuroprotective potential of glucose control and ALA. Animals were divided into 6 groups based on the intervention used, as follows: normal, diabetes (DM), DM+racemic form of ALA, DM+R form of ALA, DM+once daily insulin glargine, and DM+once daily insulin glargine with twice daily insulin glulisine...
May 7, 2018: Endocrine
https://www.readbyqxmd.com/read/29736170/susceptible-and-prognostic-genetic-factors-associated-with-diabetic-peripheral-neuropathy-a-comprehensive-literature-review
#8
REVIEW
L B L Prabodha, N D Sirisena, V H W Dissanayake
Type 2 diabetes mellitus (T2D) is a disorder of glucose metabolism. It is a complex process involving the regulation of insulin secretion, insulin sensitivity, gluconeogenesis, and glucose uptake at the cellular level. Diabetic peripheral neuropathy (DPN) is one of the debilitating complications that is present in approximately 50% of diabetic patients. It is the primary cause of diabetes-related hospital admissions and nontraumatic foot amputations. The pathogenesis of diabetic neuropathy is a complex process that involves hyperglycemia-induced oxidative stress and altered polyol metabolism that changes the nerve microvasculature, altered growth factor support, and deregulated lipid metabolism...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29719281/expression-of-nrf2-promotes-schwann-cell-mediated-sciatic-nerve-recovery-in-diabetic-peripheral-neuropathy
#9
Wei Tang, Xiangfang Chen, Haoqi Liu, Qian Lv, Junjie Zou, Yongquan Shi, Zhimin Liu
BACKGROUND/AIMS: High glucose-induced oxidative stress and inflammatory responses play an important role in painful diabetic neuropathy by activating the TLR4/NFκB signal pathway. Schwann cells (SCs) are integral to peripheral nerve biology, contributing to saltatory conduction along axons, nerve and axon development, and axonal regeneration. SCs provide a microenvironment favoring vascular regeneration but their low survival ratio in hyperglycemic conditions suppress the function to promote nerve growth...
April 26, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29709457/diabetic-peripheral-neuropathy-epidemiology-diagnosis-and-pharmacotherapy
#10
REVIEW
Zohaib Iqbal, Shazli Azmi, Rahul Yadav, Maryam Ferdousi, Mohit Kumar, Daniel J Cuthbertson, Jonathan Lim, Rayaz A Malik, Uazman Alam
PURPOSE: Diabetic peripheral neuropathy (DPN) is the commonest cause of neuropathy worldwide, and its prevalence increases with the duration of diabetes. It affects approximately half of patients with diabetes. DPN is symmetric and predominantly sensory, starting distally and gradually spreading proximally in a glove-and-stocking distribution. It causes substantial morbidity and is associated with increased mortality. The unrelenting nature of pain in this condition can negatively affect a patient's sleep, mood, and functionality and result in a poor quality of life...
April 27, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29701037/-warming-acupuncture-combined-with-conventional-acupuncture-for-diabetic-peripheral-neuropathy-with-syndrome-of-yang-deficiency-and-cold-coagulation-obstruction-of-collaterals-and-blood-stasis
#11
Guoqing Ma, Ting Ye, Zhongren Sun
OBJECTIVE: To compare the clinical efficacy differences between warming acupuncture and conventional acupuncture for diabetic peripheral neuropathy (DPN) with syndrome of yang deficiency and cold coagulation, obstruction of collaterals and blood stasis. METHODS: A total of 64 patients were randomly divided into a warming acupuncture group and a conventional acupuncture group, 32 cases in each one. Based on basic treatment of blood glucose regulation, warming acupuncture was applied at Pishu (BL 20), Shenshu (BL 23), Guanyuanshu (BL 26), Zusanli (ST 36), Chongyang (ST 42), Quchi (LI 11) and Hegu (LI 4) in the warming acupuncture group, while acupuncture was applied at the identical acupoints in the conventional acupuncture group...
March 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29696049/peripheral-neuropathy-in-children-and-adolescents-with-insulin-dependent-diabetes-mellitus
#12
Nosrat Ghaemi, Hossein Hasanabadi, Farah Ashrafzadeh, Somaye Sarvari, Hamidreza Rahimi, Somayyeh Hashemian
Objective: Type 1 diabetes mellitus (T1DM) is a chronic immune-mediated disease. Diabetic peripheral neuropathy (DPN) is an important microvascular complication of T1DM. One of the most important risk factors for the development of DPN is poor glycemic control. We evaluated the prevalence of DPN among T1DM patients and determined the association between DPN and glycated hemoglobin (HbA1c) level. Materials & Methods: The subjects were recruited prospectively upon initial evaluation at Imam Reza Hospital, Mashhad, Iran from Jan 2013 to Jan 2015...
2018: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29695014/chronic-nerve-compression-accelerates-the-progression-of-diabetic-peripheral-neuropathy-in-a-rat-model-a-study-of-gene-expression-profiling
#13
Yiji Tu, Zenggan Chen, Junda Hu, Zuoyou Ding, William C Lineaweaver, A Lee Dellon, Feng Zhang
OBJECTIVE:  This article investigates the role of chronic nerve compression in the progression of diabetic peripheral neuropathy (DPN) by gene expression profiling. METHODS:  Chronic nerve compression was created in streptozotocin (STZ)-induced diabetic rats by wrapping a silicone tube around the sciatic nerve (SCN). Neurological deficits were evaluated using pain threshold test, motor nerve conduction velocity (MNCV), and histopathologic examination. Differentially expressed genes (DGEs) and metabolic processes associated with chronic nerve compression were analyzed...
April 25, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29687216/fluoxetine-pretreatment-enhances-neurogenic-angiogenic-and-immunomodulatory-effects-of-mscs-on-experimentally-induced-diabetic-neuropathy
#14
Shaimaa A Abdelrahman, Mai A Samak, Sally M Shalaby
Being one of the most debilitating complications among diabetic patients, diabetic polyneuropathy (DPN) is a paramount point of continuous research. Stem cell therapies have shown promising results. However, limited cell survival and paracrine activities hinder its transfer from bench to bedside. We designed this study to evaluate fluoxetine-pretreatment technique of mesenchymal stem cells (MSCs) as an approach to enhance their paracrine and immunomodulatory properties in DPN. Effects of fluoxetine treatment of MSCs were tested in vitro...
April 23, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29672293/microarray-analysis-of-long-noncoding-rnas-in-female-diabetic-peripheral-neuropathy-patients
#15
Lin Luo, Lin-Dan Ji, Jiang-Jia Cai, Mei Feng, Mi Zhou, Su-Pei Hu, Jin Xu, Wen-Hua Zhou
BACKGROUND/AIMS: Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus (DM). Because of its controversial pathogenesis, DPN is still not diagnosed or managed properly in most patients. METHODS: In this study, human lncRNA microarrays were used to identify the differentially expressed lncRNAs in DM and DPN patients, and some of the discovered lncRNAs were further validated in additional 78 samples by quantitative realtime PCR (qRT-PCR)...
April 16, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29656511/neuropathic-pain-a-patient-centred-approach-to-measuring-outcomes
#16
Steve Hwang, Floortje van Nooten, Ted Wells, Aisling Ryan, Bruce Crawford, Christopher Evans, Marci English
BACKGROUND: Neuropathic pain (NP) is a complex, chronic pain state initiated by a primary lesion or dysfunction of the nervous system and presents as a variety of symptoms across multiple disease states. OBJECTIVE: To develop a patient-centred conceptual model of symptoms and impacts in subjects with diabetic peripheral neuropathy (DPN) or post-herpetic neuralgia (PHN) that can inform the measurement strategy in clinical trials. METHOD: Thirty subjects with DPN or PHN participated in in-person interviews which were performed until saturation was achieved...
April 15, 2018: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29627577/role-of-neopterin-as-a-biochemical-marker-for-peripheral-neuropathy-in-pediatric-patients-with-type-1-diabetes-relation-to-nerve-conduction-studies
#17
Nancy Samir Elbarbary, Eman Abdel Rahman Ismail, Rana Ahmed El-Hilaly, Fatma Salama Ahmed
BACKGROUND: Neopterin, a marker of inflammation and cellular immune response, is elevated in conditions of T-cell or macrophages activation. Diabetic peripheral neuropathy (DPN) is associated with inflammatory/immune processes and therefore, we hypothesized that neopterin could be used as a marker of neuropathy in type 1 diabetes mellitus (T1DM). AIM: To measure neopterin levels in children and adolescents with T1DM and assess its possible relation to DPN and nerve conduction studies (NCS)...
April 5, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29621478/hyperglycemia-induced-bcl-2-bax-mediated-apoptosis-of-schwann-cells-via-mtorc1-s6k1-inhibition-in-diabetic-peripheral-neuropathy
#18
Lin Zhu, Jun Hao, Meijuan Cheng, Cuihong Zhang, Chunxiu Huo, Yaping Liu, Wei Du, Xianghong Zhang
Schwann cell apoptosis is one of the characteristics of diabetic peripheral neuropathy (DPN). The mammalian target of rapamycin (mTOR) is a multifunctional signaling pathway that regulates cell apoptosis in various types of tissues and cells. To investigate whether the mTOR pathway is involved in cell apoptosis in the Schwann cells of DPN, diabetic mice and rat Schwann cells (RSC96) were chosen to detect phospho-mTOR (Ser 2448), phospho-S6K1 (Thr 389), phospho-4EBP1 (Thr 37/46), Bcl-2, Bax and cleaved caspase-3 by diverse pathological and biological techniques...
June 15, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29619066/efficacy-and-safety-of-the-injection-of-the-traditional-chinese-medicine-puerarin-for-the-treatment-of-diabetic-peripheral-neuropathy-a-systematic-review-and-meta-analysis-of-53-randomized-controlled-trials
#19
REVIEW
Baocheng Xie, Qinghui Wang, Chenhui Zhou, Jiahuan Wu, Daohua Xu
Objective: The injection of the traditional Chinese patent medicine puerarin has been widely used in the treatment of various diseases such as angina pectoris or ischemic stroke. We aim to evaluate the efficacy and safety of puerarin injection for the treatment of diabetic peripheral neuropathy (DPN). Methods: A systematic literature search was performed in seven medical databases from their inception until June 2017. 53 studies with RCTs, totaling 3284 patients, were included in this meta-analysis...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29610062/electrophysiological-measurements-of-diabetic-peripheral-neuropathy-a-systematic-review
#20
REVIEW
Dheyauldeen Shabeeb, Masoud Najafi, Gholamreza Hasanzadeh, Mohammed Reza Hadian, Ahmed Eleojio Musa, Alireza Shirazi
INTRODUCTION: Peripheral neuropathy is one of the main complications of diabetes mellitus. One of the features of diabetic nerve damage is abnormality of sensory and motor nerve conduction study. An electrophysiological examination can be reproduced and is also a non-invasive approach in the assessment of peripheral nerve function. Population-based and clinical studies have been conducted to validate the sensitivity of these methods. When the diagnosis was based on clinical electrophysiological examination, abnormalities were observed in all patients...
March 28, 2018: Diabetes & Metabolic Syndrome
keyword
keyword
65317
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"