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https://www.readbyqxmd.com/read/29783080/development-and-characterization-of-a-field-effect-biosensor-for-the-detection-of-acetoin
#1
Denise Molinnus, Lukas Muschallik, Laura Osorio Gonzalez, Johannes Bongaerts, Torsten Wagner, Thorsten Selmer, Petra Siegert, Michael Keusgen, Michael J Schöning
A capacitive electrolyte-insulator-semiconductor (EIS) field-effect biosensor for acetoin detection has been presented for the first time. The EIS sensor consists of a layer structure of Al/p-Si/SiO2 /Ta2 O5 /enzyme acetoin reductase. The enzyme, also referred to as butane-2,3-diol dehydrogenase from B. clausii DSM 8716T , has been recently characterized. The enzyme catalyzes the (R)-specific reduction of racemic acetoin to (R,R)- and meso-butane-2,3-diol, respectively. Two different enzyme immobilization strategies (cross-linking by using glutaraldehyde and adsorption) have been studied...
May 18, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29783077/effects-of-prolonged-exposure-and-virtual-reality-exposure-on-suicidal-ideation-in-active-duty-soldiers-an-examination-of-potential-mechanisms
#2
REVIEW
Aaron M Norr, Derek J Smolenski, Greg M Reger
OBJECTIVE: The current study sought to investigate the effects of exposure therapy on suicidal ideation (SI), as well as potential mechanistic pathways of SI reduction among active duty military personnel. METHODS: Active duty army soldiers (N = 162) were recruited from a military base in the U.S. and were enrolled in a randomized clinical trial comparing Prolonged Exposure (PE), Virtual Reality Exposure (VRE), and a wait-list control for the treatment of posttraumatic stress disorder (PTSD) stemming from deployments to Iraq or Afghanistan...
May 12, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29782990/a-certain-role-of-sod-cat-imbalance-in-pathogenesis-of-autism-spectrum-disorders
#3
Konstantin Yenkoyan, Hayk Harutyunyan, Aida Harutyunyan
The real impact of reactive oxygen species, antioxidant enzymes, mitochondrial dysfunction and chronic inflammation on the development of autism spectrum disorders (ASD) remains unclear, and even controversial. In this study we compared the plasma levels of antioxidant enzymes and their cofactors, markers of oxidative damage, and the respiratory burst in peripheral blood polymorphonuclear leukocytes (PMNL) as surrogate marker of chronic inflammation obtained from 10 children (4-10 year old) who met DSM-5 criteria and their siblings...
May 18, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29782542/validation-of-the-refugee-health-screener-15-for-the-assessment-of-perinatal-depression-among-karen-and-burmese-women-on-the-thai-myanmar-border
#4
Gracia Fellmeth, Emma Plugge, Mina Fazel, Prakaykaew Charunwattana, François Nosten, Raymond Fitzpatrick, Julie A Simpson, Rose McGready
Perinatal depression is common, and left untreated can have significant and long-lasting consequences for women, their children and their families. Migrant women are at particular risk of perinatal depression as a result of a multitude of stressors experienced before, during and after migration. Identification of perinatal depression among migrant women-particularly those living in low- and middle-income regions-remains challenging, partly due to the lack of locally-validated and culturally appropriate screens tools...
2018: PloS One
https://www.readbyqxmd.com/read/29782471/new-approach-in-acne-therapy-a-specific-bacteriocin-activity-and-a-targeted-anti-il-8-property-in-just-1-probiotic-strain-the-l-salivarius-ls03
#5
Francesca Deidda, Angela Amoruso, Stefania Nicola, Teresa Graziano, Marco Pane, Luca Mogna
GOALS: The aim of this research was to assess the antibacterial activity of Lactobacillus salivarius LS03 (DSM 22776) against Propionibacterium acnes and its anti-inflammatory properties by inhibiting P. acnes-induced interleukin-8 (IL-8) release. BACKGROUND: Acne is the most common skin disease, causing significant psychosocial problems for those afflicted. Currently available agents for acne treatment, such as oral antibiotics, have limited use. Thus, development of novel agents to treat this disease is needed...
May 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29782469/effectiveness-of-probiotics-in-children-with-functional-abdominal-pain-disorders-and-functional-constipation-a-systematic-review
#6
Carrie A M Wegh, Marc A Benninga, Merit M Tabbers
OBJECTIVE: The objective of this study was to investigate the effect of probiotics on functional abdominal pain disorders (FAPD) and functional constipation (FC). METHODS: A systematic review was conducted, searching PubMed and Cochrane databases from inception to January 2018 for randomized controlled trials (RCTs) investigating the efficacy of probiotics in children aged 4 to 18 years with FAPD or children aged 0 to 18 years with FC. RESULTS: A total of 657 citations were identified...
May 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29782312/naturalistic-driving-study-investigating-self-regulation-behavior-in-early-alzheimer-s-disease-a-pilot-study
#7
Laurence Paire-Ficout, Sylviane Lafont, Fanny Conte, Amandine Coquillat, Colette Fabrigoule, Joël Ankri, Frédéric Blanc, Cécilia Gabel, Jean-Luc Novella, Isabella Morrone, Rachid Mahmoudi
BACKGROUND: Because cognitive processes decline in the earliest stages of Alzheimer's disease (AD), the driving abilities are often affected. The naturalistic driving approach is relevant to study the driving habits and behaviors in normal or critical situations in a familiar environment of participants. OBJECTIVE: This pilot study analyzed in-car video recordings of naturalistic driving in patients with early-stage AD and in healthy controls, with a special focus on tactical self-regulation behavior...
May 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29781887/speculations-on-the-future-of-psychiatric-diagnosis
#8
A John Rush, Hisham M Ibrahim
The Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-V), criterion symptom listings are frequently used in clinical practice as checklists to make diagnoses. However, most DSM-V conditions are, in fact, syndromes, that is, collections of signs and symptoms that commonly occur together in the clinic. This report discusses the value of syndromes in medicine and psychiatry. It is argued that a more precise future enumeration of brain circuits and the pathogenesis of psychiatric conditions will help us better understand and treat psychiatric syndromes, but they are unlikely to eliminate the need to categorize psychiatric conditions...
May 17, 2018: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29781802/zobellella-maritima-sp-nov-a-polycyclic-aromatic-hydrocarbon-degrading-bacterium-isolated-from-beach-sediment
#9
Dong Wan Lee, Hanbyul Lee, Bong-Oh Kwon, Jong Seong Khim, Un Hyuk Yim, Hongjae Park, Byeonghyeok Park, In-Geol Choi, Beom Seok Kim, Jae-Jin Kim
A novel Gram-stain-negative, motile, rod-shaped bacterium, designated strain 102-Py4T , was isolated from Sinduri beach sediment in Taean, Republic of Korea. Cells were aerobic, oxidase-positive and catalase-positive. The isolate grew optimally with 1-3 % (w/v) NaCl, but NaCl is not an absolute requirement for growth. 16S rRNA gene sequence analysis revealed that strain 102-Py4T clustered together with Zobellella aerophila and fell within the clade formed by recognized species of the genus Zobellella. Its closest phylogenetic neighbours were Z...
May 21, 2018: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29781801/methanonatronarchaeum-thermophilum-gen-nov-sp-nov-and-candidatus-methanohalarchaeum-thermophilum-extremely-halo-natrono-philic-methyl-reducing-methanogens-from-hypersaline-lakes-comprising-a-new-euryarchaeal-class-methanonatronarchaeia-classis-nov
#10
Dimitry Y Sorokin, Alexander Y Merkel, Ben Abbas, Kira S Makarova, W Irene C Rijpstra, M Koenen, Jaap S Sinninghe Damsté, Erwin A Galinski, Eugene V Koonin, Mark C M van Loosdrecht
Methanogenic enrichments from hypersaline lakes at moderate thermophilic conditions have resulted in the cultivation of an unknown deep lineage of euryarchaeota related to the class Halobacteria. Eleven soda lake isolates and three salt lake enrichment cultures were methyl-reducing methanogens that utilize C1 methylated compounds as electron acceptors and H2 or formate as electron donors, but they were unable to grow on either substrates alone or to form methane from acetate. They are extreme halophiles, growing optimally at 4 M total Na+ and the first representatives of methanogens employing the 'salt-in' osmoprotective mechanism...
May 21, 2018: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29781652/the-agreement-between-clients-and-their-therapists-ratings-of-personality-disorder-traits
#11
Douglas B Samuel, Takakuni Suzuki, Meredith A Bucher, Sarah A Griffin
OBJECTIVE: Treating clinicians provide the majority of mental health diagnoses, yet little is known about the validity of their routine diagnoses, including the agreement with clients' self-reports. This is particularly notable for personality disorders (PDs) as the literature suggests weak agreement between therapists and clients. Existing research has been limited by a focus on PD categories and brief therapist-report measures. Furthermore, although self-reports of PD have been criticized for underreporting, very few data have compared them with therapist report in terms of mean level...
June 2018: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/29781302/does-continuing-family-based-treatment-for-adolescent-anorexia-nervosa-improve-outcomes-in-those-not-remitted-after-20-sessions
#12
Andrew Wallis, Jane Miskovic-Wheatley, Sloane Madden, Colleen Alford, Paul Rhodes, Stephen Touyz
OBJECTIVE: Our aim was to investigate the benefit of ongoing family-based treatment (FBT) sessions for adolescent anorexia nervosa if remission criteria were not met at session 20. METHOD: Participants were 69 medically unstable adolescents with Diagnostic and Statistical Manual of Mental Disorders (4th ed; DSM-IV) anorexia nervosa from a randomized controlled trial investigating length of hospital admission prior to outpatient FBT. Participants were divided post hoc into those meeting remission criteria at session 20 ( n = 16), those that had not remitted but continued with FBT ( n = 39) and those who ceased FBT undertaking alternative treatments ( n = 14)...
May 1, 2018: Clinical Child Psychology and Psychiatry
https://www.readbyqxmd.com/read/29779964/childhood-trauma-and-clinical-high-risk-for-psychosis
#13
Rachel L Loewy, Sarah Corey, Felix Amirfathi, Sawsan Dabit, Daniel Fulford, Rahel Pearson, Jessica P Y Hua, Danielle Schlosser, Barbara K Stuart, Daniel H Mathalon, Sophia Vinogradov
As a risk factor for psychosis, childhood trauma rates are elevated in the clinical-high-risk (CHR) syndrome compared to the general population. However, it is unknown whether trauma is typically experienced in childhood or adolescence/young adulthood, whether it occurred prior to CHR syndrome onset, and how severe trauma relates to presenting symptoms. In this study, we examined the relationship of trauma history to symptoms and functioning in individuals diagnosed with the CHR syndrome on the Structured Interview for Psychosis-Risk Syndromes (N = 103)...
May 18, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29779147/promicromonospora-viridis-sp-nov-a-novel-actinomycete-isolated-from-soil
#14
Liying Jin, Junwei Zhao, Shanwen Jiang, Yang Zhao, Xiaoyang Han, Xiaowei Guo, Xiangjing Wang, Wensheng Xiang
Two Gram-stain positive, aerobic actinomycete strains, designated NEAU-JGR1T and NEAU-JGC41, were isolated from soil collected from Fairy Lake Botanical Garden in Shenzhen, Guangdong Province, south of China. The 16S rRNA gene sequences analysis showed that the two strains exhibited 99.5% 16S rRNA gene sequence similarity with each other and were closely related to Promicromonospora thailandica JCM 17130T (99.4, 99.3%) and Promicromonospora citrea DSM 43110T (99.2, 99.2%). Phylogenetic analysis based on the 16S rRNA gene sequences indicated that the two strains clustered together and formed a cluster with P...
May 19, 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29778294/the-association-between-psychotic-experiences-and-health-related-quality-of-life-a-cross-national-analysis-based-on-world-mental-health-surveys
#15
Jordi Alonso, Sukanta Saha, Carmen C W Lim, Sergio Aguilar-Gaxiola, Ali Al-Hamzawi, Corina Benjet, Evelyn J Bromet, Louisa Degenhardt, Giovanni de Girolamo, Oluyomi Esan, Silvia Florescu, Oye Gureje, Josep M Haro, Chiyi Hu, Elie G Karam, Georges Karam, Viviane Kovess-Masfety, Jean-Pierre Lepine, Sing Lee, Zeina Mneimneh, Fernando Navarro-Mateu, Jose Posada-Villa, Nancy A Sampson, Kate M Scott, Juan Carlos Stagnaro, Margreet Ten Have, Maria Carmen Viana, Ronald C Kessler, John J McGrath
Psychotic experiences (PEs) are associated with a range of mental and physical disorders, and disability, but little is known about the association between PEs and aspects of health-related quality of life (HRQoL). We aimed to investigate the association between PEs and five HRQoL indicators with various adjustments. Using data from the WHO World Mental Health surveys (n = 33,370 adult respondents from 19 countries), we assessed for PEs and five HRQoL indicators (self-rated physical or mental health, perceived level of stigma (embarrassment and discrimination), and social network burden)...
May 16, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29778286/-epidemiology-of-alcohol-dependence
#16
Xavier Laqueille, Marjorie Lacombe, Alain Dervaux
Excessive alcohol consumption is the second leading preventable cause of death in France (49,000/year), after tobacco consumption. Several recent studies found that the alcohol-related negative health consequences may occurs with small amounts of alcohol, in particular cancers. Therefore, the risk thresholds for alcohol consumption have been recently recommended not to be higher than 100g/week. Early age of onset of alcohol use is a strong predictor of alcohol use disorders and alcohol-related negative health outcomes...
May 16, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29778071/anxious-distress-in-depressed-outpatients-prevalence-comorbidity-and-incremental-validity
#17
Anthony J Rosellini, Michelle L Bourgeois, Jeannette Correa, Esther S Tung, Svetlana Goncharenko, Timothy A Brown
The goals of this study were to estimate the prevalence of the DSM-5 anxious distress specifier (AD) among depressed outpatients, to examine associations of AD with comorbid diagnoses, and to test the incremental validity of AD over comorbidity in predicting functional impairment and severity of anxiety and depression symptoms. The sample was 237 outpatients diagnosed with major depressive disorder (MDD) or persistent depressive disorder (PDD), with and without AD, using the Anxiety and Related Disorders Interview Schedule for DSM-5...
May 8, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29777159/identification-of-mycobacterium-chimaera-in-heater-cooler-units-in-china
#18
Xiaoxia Zhang, Ji Lin, Yu Feng, Xiaohui Wang, Alan McNally, Zhiyong Zong
A global outbreak of infections due to Mycobacterium chimaera has been linked to the LivaNova (formerly Sorin) 3 T heater-cooler units (HCUs). We performed a study to investigate M. chimaera from HCUs in China. Water samples were collected from all 3 T HCUs (n = 5) at our hospital in May 2017. Mycobacteria isolates were subjected to genome sequencing using the HiSeq X10 Sequencer. Species were identified based on average nucleotide identity with M. chimaera type strain DSM 44623T . Paired-end reads of all M...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29776731/comorbidity-in-illness-induced-posttraumatic-stress-disorder-versus-posttraumatic-stress-disorder-due-to-external-events-in-a-nationally-representative-study
#19
Jordana L Sommer, Natalie Mota, Donald Edmondson, Renée El-Gabalawy
OBJECTIVE: The current study compared physical and mental health characteristics and quality of life of illness-induced posttraumatic stress disorder (PTSD) versus those with PTSD due to external traumatic events in a population-based sample. METHOD: PTSD was assessed with the Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS-5) using DSM-5 criteria in the 2012-2013 National Epidemiologic Survey on Alcohol and Related Conditions. Participants with past-year PTSD (n = 1779) were categorized into two groups: illness-induced (6...
May 10, 2018: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29776663/barriers-and-facilitators-to-diabetes-self-management-in-a-primary-care-setting-patient-perspectives
#20
Rahul Khairnar, Khalid M Kamal, Vincent Giannetti, Nilanjana Dwibedi, Jamie McConaha
BACKGROUND: Diabetes self-management (DSM) is a key element in the overall management of type-2 diabetes (T2DM). Identifying barriers and facilitators to DSM and addressing them is a critical step in achieving improved health outcomes in this population. OBJECTIVE: To assess patient reported barriers and facilitators to self-management of T2DM in a primary care setting. METHODS: This cross sectional study combined patient survey data with electronic medical record (EMR) data...
May 9, 2018: Research in Social & Administrative Pharmacy: RSAP
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