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Assessment cognitive decline

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https://www.readbyqxmd.com/read/29244786/functional-assessment-as-a-predictor-of-cognitive-impairment-a-retrospective-cohort-study
#1
Gustavo Alberto Sandival Ampuero, Fernando M Runzer-Colmenares, José F Parodi
INTRODUCTION: It is estimated that major neurocognitive disorders will affect 115.4 million people by 2050, representing a significant financial burden for society. Likewise, functional dependence for basic or instrumental activities of daily life is usually a consequence of the greater prevalence of disabling pathologies, and of the progressive decrease of the physiological reserve due to aging. OBJECTIVES: To determine the ratio between the functional test and prediction of deterioration of cognitive function in geriatric patients...
December 12, 2017: Medwave
https://www.readbyqxmd.com/read/29244089/the-historical-progression-from-adl-scrutiny-to-iadl-to-advanced-adl-assessing-functional-status-in-the-earliest-stages-of-dementia
#2
Robert Fieo, Laura Zahodne, Ming X Tang, Jennifer J Manly, Ron Cohen, Yaakov Stern
Background: Decrements in instrumental activities (IADL) have been observed in the prodromal phase of dementia. Given the long pre-dementia stage in neuro-degenerative diseases, it has been proposed that subtle functional changes may precede clinical IADL impairment. Incorporating more challenging advanced ADLs (e.g., volunteer work) into the assessment process may increase the sensitivity of functional measures, thus expanding the window for monitoring or interventions. Methods: Longitudinal cohort study (follow-ups, 18-24 month), subjects aged >60 (n=3635)...
December 13, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29244054/a-systematic-review-for-functional-neuroimaging-studies-of-cognitive-reserve-across-the-cognitive-aging-spectrum
#3
Mia Anthony, Feng Lin
Objective: Cognitive reserve has been proposed to explain the discrepancy between clinical symptoms and the effects of aging or Alzheimer's pathology. Functional magnetic resonance imaging (fMRI) may help elucidate how neural reserve and compensation delay cognitive decline and identify brain regions associated with cognitive reserve. This systematic review evaluated neural correlates of cognitive reserve via fMRI (resting-state and task-related) studies across the cognitive aging spectrum (i...
December 13, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29243120/validated-alzheimer-s-disease-risk-index-anu-adri-is-associated-with-smaller-volumes-in-the-default-mode-network-in-the-early-60s
#4
Nicolas Cherbuin, Marnie E Shaw, Erin Walsh, Perminder Sachdev, Kaarin J Anstey
Strong evidence is available suggesting that effective reduction of exposure to demonstrated modifiable risk factors in mid-life or before could significantly decrease the incidence of Alzheimer's disease (AD) and delay its onset. A key ingredient to achieving this goal is the reliable identification of individuals at risk well before they develop clinical symptoms. The aim of this study was to provide further neuroimaging evidence of the effectiveness of a validated tool, the ANU Alzheimer's Disease Risk Index, for the assessment of future risk of cognitive decline...
December 14, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29242718/a-bayesian-assessment-of-real-world-behavior-during-multitasking
#5
Jeroen H M Bergmann, Joan Fei, David A Green, Amir Hussain, Newton Howard
Multitasking is common in everyday life, but its effect on activities of daily living is not well understood. Critical appraisal of performance for both healthy individuals and patients is required. Motor activities during meal preparation were monitored in healthy individuals with a wearable sensor network during single and multitask conditions. Motor performance was quantified by the median frequencies (fm) of hand trajectories and wrist accelerations. The probability that multitasking occurred based on the obtained motor information was estimated using a Naïve Bayes Model, with a specific focus on the single and triple loading conditions...
2017: Cognitive Computation
https://www.readbyqxmd.com/read/29240924/effect-of-omega-3-fatty-acids-on-cognition-an-updated-systematic-review-of-randomized-clinical-trials
#6
Oscar D Rangel-Huerta, Angel Gil
Context: The increasing number of studies on the effects of n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) on health, particularly cognition, in the last 5 years reflects the growing interest in this area of research. Objective: The aim for this systematic review was to evaluate the scientific evidence published in the last 5 years (2012-2017) on the effects of n-3 LC-PUFA intake on cognition, cognitive development, and cognitive decline to determine whether n-3 LC-PUFAs support cognitive development and prevent cognitive decline...
December 12, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/29240562/occurrence-of-impaired-physical-performance-in-memory-clinic-patients-with-cerebral-small-vessel-disease
#7
Jurre H Verwer, Geert-Jan Biessels, Rutger Heinen, Lieza G Exalto, Marielle H Emmelot-Vonk, Huiberdina L Koek
Cerebral small vessel disease (CSVD) occurs often in memory clinic patients. Apart from cognitive deficits, these patients can express physical decline, which predicts adverse health outcomes. In this study, we investigated the cooccurrence of clinically relevant impairments in physical performance and CSVD in memory clinic patients. We included 131 patients with vascular brain injury, mild cognitive impairment or Alzheimer disease with available 3T MRI and physical performance scores. CSVD was visually rated according to 3 subtypes and as a total burden score, composed of the presence of white matter hyperintensities (WMH), lacunar infarcts (LI), and cerebral microbleeds (MB)...
December 13, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29239746/stepping-reaction-time-and-gait-adaptability-are-significantly-impaired-in-people-with-parkinson-s-disease-implications-for-fall-risk
#8
Maria Joana D Caetano, Stephen R Lord, Natalie E Allen, Matthew A Brodie, Jooeun Song, Serene S Paul, Colleen G Canning, Jasmine C Menant
BACKGROUND: Decline in the ability to take effective steps and to adapt gait, particularly under challenging conditions, may be important reasons why people with Parkinson's disease (PD) have an increased risk of falling. This study aimed to determine the extent of stepping and gait adaptability impairments in PD individuals as well as their associations with PD symptoms, cognitive function and previous falls. METHODS: Thirty-three older people with PD and 33 controls were assessed in choice stepping reaction time, Stroop stepping and gait adaptability tests; measurements identified as fall risk factors in older adults...
November 22, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29238394/physical-exercise-as-stabilizer-for-alzheimer-s-disease-cognitive-decline-current-status
#9
Sergio Machado, Alberto Souza de Sá Filho, Matheus Wilbert, Gabriela Barbieri, Victor Almeida, Alexandre Gurgel, Charles V Rosa, Victor Lins, Alexandre Paixão, Kamila Santana, Gabriel Ramos, Geraldo Maranhão Neto, Flá Paes, Nuno Rocha, Eric Murillo-Rodriguez
Introduction: Mental health decline is one of the main responsible factors for augments in health care costs, and diagnosis of Alzheimer's disease (AD). Some studies stated physical exercise is useful for reduction in cognitive decline and AD. Moreover, a recent review argued that evidence are scarce due to few studies published and lack of configuration information of exercise protocol, such as intensity and duration of exercise, number of sessions and other relevant data, to allow appropriate assessment...
2017: Clinical Practice and Epidemiology in Mental Health: CP & EMH
https://www.readbyqxmd.com/read/29238393/influence-of-severe-carotid-stenosis-on-cognition-depressive-symptoms-and-quality-of-life
#10
Elina Pucite, Ildze Krievina, Evija Miglane, Renars Erts, Dainis Krievins
Background: Carotid artery disease is not just a causal risk factor of ischemic stroke, but may predispose patients to depressive symptoms and low health related quality of life (HRQoL). Objectives: The objectives of the present study were to assess the association between severe carotid artery stenosis (CAS) and cognitive impairment, frequency of depressive symptoms and status of HRQoL. Methods: Cross - sectional study involved 55 patients with severe CAS and 54 patients with lower extremity peripheral artery disease (PAD)...
2017: Clinical Practice and Epidemiology in Mental Health: CP & EMH
https://www.readbyqxmd.com/read/29238302/sevoflurane-induces-exaggerated-and-persistent-cognitive-decline-in-a-type-ii-diabetic-rat-model-by-aggregating-hippocampal-inflammation
#11
Dongliang Li, Lingling Liu, Liang Li, Xingang Li, Bin Huang, Changqing Zhou, Zhaohang Zhang, Chunling Wang, Ping Dong, Xiyan Zhang, Bo Yang, Li Zhang
Recent studies show that a moderate duration of sevoflurane, one of the most commonly used volatile anesthetics in clinical practice, does not induce cognitive impairment in animals under physiological conditions. However, the influence of sevoflurane on cognitive function under diabetic conditions remains unclear. The aim of this study was to determine whether sevoflurane causes cognitive decline in a rat model of type 2 diabetes mellitus (DM) and if so, to explore a possible underlying mechanism. Diabetic Goto-Kakizaki (GK) rats and non-diabetic Wistar rats underwent 2...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29236984/longitudinal-association-between-brain-amyloid-beta-and-gait-in-the-mayo-clinic-study-of-aging
#12
Alexandra M V Wennberg, Timothy G Lesnick, Christopher G Schwarz, Rodolfo Savica, Clinton E Hagen, Rosebud O Roberts, David S Knopman, John H Hollman, Prashanthi Vemuri, Clifford R Jack, Ronald C Petersen, Michelle M Mielke
Background: The longitudinal association between cerebral amyloid-beta (Aβ) and change in gait, and whether this association is mediated by cortical thickness, has yet to be determined. Methods: We included 439 clinically normal (CN) participants, aged 50-69 years and enrolled in the Mayo Clinic Study of Aging with cerebral Aβ, cortical thickness, and gait measurements. Cerebral Aβ deposition was assessed by Pittsburgh Compound B (PiB)-PET in multiple regions of interest (ROIs) (i...
December 9, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29235076/a-comparison-of-the-impact-of-physical-exercise-cognitive-training-and-combined-intervention-on-spontaneous-walking-speed-in-older-adults
#13
Kristell Pothier, Christine Gagnon, Sarah A Fraser, Maxime Lussier, Laurence Desjardins-Crépeau, Nicolas Berryman, Marie-Jeanne Kergoat, T T Minh Vu, Karen Z H Li, Laurent Bosquet, Louis Bherer
BACKGROUND: Spontaneous walking speed (SWS) is one of the most important indicators of health in older adults. Studies have shown benefits of physical trainings on SWS in older adults but the impact of cognitive training and multidomain interventions remains understudied. AIMS: This original study aimed at comparing the impact of aerobic/resistance exercise, computerized cognitive training and the combination of both interventions compared with active control conditions on SWS in healthy older adults...
December 12, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29234277/investigating-the-usability-and-acute-effects-of-a-bedside-video-console-to-prefrontal-cortical-activity-alterations-a-preclinical-study-in-healthy-elderly
#14
Ruud H Knols, Jaap Swanenburg, Dino De Bon, Federico Gennaro, Martin Wolf, Bernard Krüger, Dominique Bettex, Eling D de Bruin
Elderly people at risk of developing cognitive decline; e.g., following surgery, may benefit from structured, challenging, and repetitive cognitive video training. This study assessed usability and acute effects of a newly developed bedside console (COPHYCON). Fifteen healthy elderly individuals performed a one-time 80-min intervention, including cognitive video games aimed at improving awareness and selective attention. Perceived usefulness and perceived ease of use (Technology Acceptance Model) were assessed together with measures of the achieved game level, reaction times, (in-) correct responses during ALERT and SELECT game play...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/29233002/social-participation-following-a-stroke-an-assessment-in-accordance-with-the-international-classification-of-functioning-disability-and-health
#15
Soraia Micaela Silva, João Carlos Ferrari Corrêa, Gabriela Santos Pereira, Fernanda Ishida Corrêa
OBJECTIVE: Evaluate, code and qualify the participation of Brazilian stroke survivors based on the international classification of functioning, disability and health (ICF) and identify predictors of post-stroke participation. METHODS: An exploratory, observational, cross-sectional study was conducted involving 78 individuals with hemiparesis stemming from a stroke. The stroke specific quality of life (SS-QOL) was used to evaluate the participation component of the ICF...
December 13, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29232539/how-to-identify-and-manage-cognitive-dysfunction-after-breast-cancer-treatment
#16
Marie Lange, Florence Joly
Attention and memory dysfunction is a common complaint among patients with breast cancer that can be reported during and up to several years after treatment. It can negatively affect patients' quality of life and their ability to work. This phenomenon has mainly been studied in patients with breast cancer who are treated with adjuvant chemotherapy. Women describe concentration problems and difficulties with word finding, multitasking, or remembering new information, as well as more effort and time needed to accomplish these tasks...
December 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29230169/eye-gaze-and-aging-selective-and-combined-effects-of-working-memory-and-inhibitory-control
#17
Trevor J Crawford, Eleanor S Smith, Donna M Berry
Eye-tracking is increasingly studied as a cognitive and biological marker for the early signs of neuropsychological and psychiatric disorders. However, in order to make further progress, a more comprehensive understanding of the age-related effects on eye-tracking is essential. The antisaccade task requires participants to make saccadic eye movements away from a prepotent stimulus. Speculation on the cause of the observed age-related differences in the antisaccade task largely centers around two sources of cognitive dysfunction: inhibitory control (IC) and working memory (WM)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29228437/shisha-smoking-impact-on-cognitive-functions-impairments-in-healthy-adults
#18
S A Meo, S Bashir, Z Almubarak, Y Alsubaie, H Almutawa
OBJECTIVE: Shisha smoking is becoming highly prevalent and is a predominant mode of tobacco use particularly amongst the young generation around the globe. This study aims to investigate whether or not shisha smoking impairs the cognitive functioning in adolescents. SUBJECTS AND METHODS: We recruited 65 (32 control subjects and 33 shisha smokers) apparently healthy male volunteers. The first group consisted of 33 volunteer male shisha smoker subjects with mean age 24...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29228203/in-vivo-cholinergic-basal-forebrain-atrophy-predicts-cognitive-decline-in-de-novo-parkinson-s-disease
#19
Nicola J Ray, Steven Bradburn, Christopher Murgatroyd, Umar Toseeb, Pablo Mir, George K Kountouriotis, Stefan J Teipel, Michel J Grothe
Cognitive impairments are a prevalent and disabling non-motor complication of Parkinson's disease, but with variable expression and progression. The onset of serious cognitive decline occurs alongside substantial cholinergic denervation, but imprecision of previously available techniques for in vivo measurement of cholinergic degeneration limit their use as predictive cognitive biomarkers. However, recent developments in stereotactic mapping of the cholinergic basal forebrain have been found useful for predicting cognitive decline in prodromal stages of Alzheimer's disease...
December 8, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29227799/cognitive-function-after-status-epilepticus-versus-after-multiple-generalized-tonic-clonic-seizures
#20
Kjersti N Power, Arne Gramstad, Nils Erik Gilhus, Karl Ove Hufthammer, Bernt A Engelsen
OBJECTIVES: Status epilepticus (SE) is considered a risk for cognitive impairment. Studies have indicated that SE cause more cognitive decline than multiple lifetime generalized tonic clonic (GTC) seizures. The aim of the study was to investigate whether patients suffering from SE or from multiple lifetime GTC seizures have cognitive dysfunction, and if the disabilities differ between these groups. MATERIALS AND METHODS: Patients suffering from SE were evaluated shortly after the clinical post-ictal phase and again after one year...
November 28, 2017: Epilepsy Research
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