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https://www.readbyqxmd.com/read/29040533/hippocampal-phosphorylated-tau-induced-cognitive-decline-dendritic-spine-loss-and-mitochondrial-abnormalities-in-a-mouse-model-of-alzheimer-s-disease
#1
Ramesh Kandimalla, Maria Manczak, Xiangling Yin, Rui Wang, P Hemachandra Reddy
The purpose of our study was to understand the toxic effects of hippocampal phosphorylated tau in tau mice. Using rotarod and Morris Water Maze tests, immunoblotting & immunofluorescence, Golgi-cox staining and transmission electron microscopy, we assessed cognitive behavior, measured protein levels of mitochondrial dynamics, MAP2, total & phosphorylated tau, and quantified dendritic spines and mitochondrial number and length in 12-month-old tau mice with P301L mutation. Mitochondrial function was assessed by measuring the levels of H2O2, lipid peroxidation, cytochrome oxidase activity and mitochondrial ATP...
October 12, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29039993/physical-activity-pre-and-post-dementia-english-longitudinal-study-of-ageing
#2
Mira Soni, Martin Orrell, Stephan Bandelow, Andrew Steptoe, Snorri Rafnsson, Eleonora d'Orsi, Andre Xavier, Eef Hogervorst
BACKGROUND: To inform public health interventions, further investigation is needed to identify: (1) frequency/intensity of everyday physical activity (PA) needed to reduce dementia risk; (2) whether post-diagnosis reduction in PA is associated with cognitive outcomes in people with dementia. METHODS: Data from 11,391 men and women (aged ≥50) were obtained from the English Longitudinal Study of Ageing cohort. Assessments were carried out at baseline (2002-2003) and at biannual follow-ups (2004-2013)...
October 17, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/29036824/alzheimer-s-disease-biomarkers-and-future-decline-in-cognitive-normal-older-adults
#3
Julien Dumurgier, Bernard J Hanseeuw, Frances B Hatling, Kelly A Judge, Aaron P Schultz, Jasmeer P Chhatwal, Deborah Blacker, Reisa A Sperling, Keith A Johnson, Bradley T Hyman, Teresa Gómez-Isla
BACKGROUND: Identifying older adults at risk of cognitive decline represents a challenge as Alzheimer's disease (AD) modifying therapies move toward preclinical stages. OBJECTIVE: To investigate the relationship between AD biomarkers and subsequent change in cognition in a cohort of cognitively intact older adults. METHODS: 84 cognitively normal subjects (mean age 72.0 years, 59% women) were recruited through the Massachusetts Alzheimer's Disease Research Center and the Harvard Aging Brain Study and followed over 3 years...
October 12, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29036813/association-between-later-life-lifestyle-factors-and-alzheimer-s-disease-biomarkers-in-non-demented-individuals-a-longitudinal-descriptive-cohort-study
#4
Babette L R Reijs, Stephanie J B Vos, Hilkka Soininen, Jyrki Lötjonen, Juha Koikkalainen, Maria Pikkarainen, Anette Hall, Ritva Vanninen, Yawu Liu, Sanna-Kaisa Herukka, Yvonne Freund-Levi, Giovanni B Frisoni, Lutz Frölich, Flavio Nobili, Marcel Olde Rikkert, Luiza Spiru, Magda Tsolaki, Åsa K Wallin, Philip Scheltens, Frans Verhey, Pieter Jelle Visser
BACKGROUND: Lifestyle factors have been associated with the risk of dementia, but the association with Alzheimer's disease (AD) remains unclear. OBJECTIVE: To examine the association between later life lifestyle factors and AD biomarkers (i.e., amyloid-β 1-42 (Aβ42) and tau in cerebrospinal fluid (CSF), and hippocampal volume) in individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI). In addition, to examine the effect of later life lifestyle factors on developing AD-type dementia in individuals with MCI...
October 11, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29034310/further-education-improves-cognitive-reserve-and-triggers-improvement-in-selective-cognitive-functions-in-older-adults-the-tasmanian-healthy-brain-project
#5
Megan E Thow, Mathew J Summers, Nichole L Saunders, Jeffery J Summers, Karen Ritchie, James C Vickers
INTRODUCTION: The strong link between early-life education and subsequent reduced risk of dementia suggests that education in later life could enhance cognitive function and may reduce age-related cognitive decline and protect against dementia. METHODS: Episodic memory, working memory, executive function, and language processing performances were assessed annually over 4 years in 359 healthy older adults who attended university for a minimum of 12 months (intervention) and were compared against 100 healthy adult controls...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29034078/recent-advances-in-cancer-surgery-in-older-patients
#6
REVIEW
Siri Rostoft, Riccardo A Audisio
Age is the most important risk factor for the occurrence of cancer, and a declining mortality from heart disease and other non-cancer causes leaves an older population that is at high risk of developing cancer. Choosing the optimal treatment for older cancer patients may be a challenge. Firstly, older age and associated factors such as comorbidities, functional limitations, and cognitive impairment are risk factors for adverse effects of cancer treatment. Secondly, older patients are often excluded from clinical trials, and current clinical guidelines rarely address how to manage cancer in patients who have comorbidities or functional limitations...
2017: F1000Research
https://www.readbyqxmd.com/read/29033827/excessive-sleepiness-and-longer-nighttime-in-bed-increase-the-risk-of-cognitive-decline-in-frail-elderly-subjects-the-mapt-sleep-study
#7
Audrey Gabelle, Laure-Anne Gutierrez, Isabelle Jaussent, Sophie Navucet, Caroline Grasselli, Karim Bennys, Cécilia Marelli, Renaud David, Sandrine Andrieu, Claudine Berr, Bruno Vellas, Yves Dauvilliers
Objective: To identify self-reported sleep-wake disturbances that increase the risk of cognitive decline over 1-year follow-up in frail participants. Background: Risk factors for cognitive impairment need to be better identified especially at earliest stages of the pathogenesis. Sleep-wake disturbances may be critical factors to consider and were thus being assessed in this at-risk population for cognitive decline. Methods: Frail elderly participants aged ≥70 years were selected from a subsample of the Multi-domain Alzheimer Preventive Trial (MAPT) for a sleep assessment (MAPT-sleep study) at 18-month follow-up (M18)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29032750/longitudinal-neuropsychological-outcome-in-taiwanese-alzheimer-s-disease-patients-treated-with-medication
#8
Pi-Shan Sung, Meng-Ni Wu, Ping-Song Chou, Hui-Chen Su, Sheng-Hsiang Lin, Yuan-Han Yang
Background The longitudinal change of neuropsychological tests (NPTs) in treated Alzheimer's disease (AD) is essential to understand the interplay of a therapeutic response from medication and a disease decline due to degenerative processes. The aim of our study is to investigate the annual cognitive progression as measured by commonly used NPTs in treated AD patients and to assess the potential predictors of disease progression. Methods Participants (N=455) diagnosed with AD and treated with cholinesterase inhibitors (ChEIs) or memantine at memory clinics in three hospitals in southern Taiwan from January 2009 to December 2014 were enrolled in this prospectively registered study...
October 10, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29032016/neuropsychological-outcomes-following-paediatric-temporal-lobe-surgery-for-epilepsies-evidence-from-a-systematic-review
#9
REVIEW
Alice E Flint, Mitch Waterman, Grace Bowmer, Gayatri Vadlamani, Paul Chumas, Matthew C H J Morrall
OBJECTIVE: The systematic review aimed to assess the neuropsychological outcomes of temporal lobe resections for epilepsy in children. Additional objectives included determining whether earlier age at surgery leads to better neuropsychological outcomes; the relationships between and predictors of these outcomes. METHODS: Using advanced search terms, a systematic review of electronic databases was conducted, comprising MEDLINE, Embase, PsycINFO, Global Health, Web of Science and CINAHL...
September 19, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29029762/thinner-cortex-in-patients-with-subjective-cognitive-decline-is-associated-with-steeper-decline-of-memory
#10
Sander C J Verfaillie, Rosalinde E Slot, Betty M Tijms, Femke Bouwman, Marije R Benedictus, Jozefien M Overbeek, Teddy Koene, Hugo Vrenken, Philip Scheltens, Frederik Barkhof, Wiesje M van der Flier
We aimed to investigate associations between regional cortical thickness and rate of decline over time in 4 cognitive domains in patients with subjective cognitive decline (SCD). We included 233 SCD patients with the total number of 654 neuropsychological assessments (median = 3, range = 2-8) and available baseline magnetic resonance imaging from the Amsterdam Dementia Cohort (125 males, age: 63 ± 9, Mini-Mental State Examination score: 28 ± 2). We assessed longitudinal cognitive functioning at baseline and follow-up in 4 cognitive domains (composite Z-scores): memory, attention, executive function, and language...
September 20, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29029571/encoding-strategy-training-and-self-reported-everyday-prospective-memory-in-people-with-parkinson-disease-a-randomized-controlled-trial
#11
Susan Goedeken, Cathryne Potempa, Eliza M Prager, Erin R Foster
Objective To compare the effects of laboratory-based training in implementation intentions (II; experimental strategy) and verbal rehearsal (VR; control strategy) on self-reported everyday prospective memory among people with Parkinson disease (PD) and to investigate potential correlates of change in self-reported everyday prospective memory in response to this training. Method This was a randomized-controlled trial. Participants with mild to moderate PD without dementia underwent one session of training in either II (n = 25) or VR (n = 27)...
October 13, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29028937/abnormal-structural-brain-connectome-in-individuals-with-preclinical-alzheimer-s-disease
#12
Joana B Pereira, Danielle van Westen, Erik Stomrud, Tor Olof Strandberg, Giovanni Volpe, Eric Westman, Oskar Hansson
Alzheimer's disease has a long preclinical phase during which amyloid pathology and neurodegeneration accumulate in the brain without producing overt cognitive deficits. It is currently unclear whether these early disease stages are associated with a progressive disruption in the communication between brain regions that subsequently leads to cognitive decline and dementia. In this study we assessed the organization of structural networks in cognitively normal (CN) individuals harboring amyloid pathology (A+N-), neurodegeneration (A-N+), or both (A+N+) from the prospective and longitudinal Swedish BioFINDER study...
October 3, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29028908/negative-affect-is-associated-with-higher-risk-of-incident-cognitive-impairment-in-nondepressed-postmenopausal-women
#13
Laura E Korthauer, Joseph Goveas, Mark A Espeland, Sally A Shumaker, Katelyn R Garcia, Hilary Tindle, Elena Salmoirago-Blotcher, Kaycee M Sink, Leslie Vaughan, Stephen R Rapp, Susan M Resnick, Ira Driscoll
BACKGROUND: Positive affect (PA) and negative affect (NA) reflect subjective emotional experiences. Although related to depression and anxiety, these dimensions are distinct constructs representing affective states and patterns. Prior studies suggest that elevated depressive symptoms are associated with risk of mild cognitive impairment (MCI) and probable dementia, but whether affective states are associated with cognitive impairment is still unknown. The present study examined relationships between baseline affective states and cognitive impairment (MCI, probable dementia) in non-depressed women...
September 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29027841/diffusion-tensor-tractography-in-cerebral-small-vessel-disease-correlation-with-cognitive-function
#14
Maria M D'Souza, S P Gorthi, Kunal Vadwala, Richa Trivedi, C Vijayakumar, Prabhjot Kaur, Subash Khushu
Background Patients with cerebral small vessel disease may suffer from varying levels of cognitive deficit and may progress on to vascular dementia. The extent of involvement, as seen on conventional magnetic resonance (MR) measures, correlates poorly with the level of cognitive decline. The purpose of this study was to investigate the utility of diffusion tensor imaging (DTI) as a marker for white matter damage in small vessel disease and to assess its correlation with cognitive function. Methods Thirty consecutive patients with cerebral small vessel disease underwent conventional MR imaging, DTI, and neuropsychological assessment...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/29026971/is-impaired-cerebral-vasoreactivity-an-early-marker-of-cognitive-decline-in-multiple-sclerosis-patients
#15
Aude Metzger, Emmanuelle Le Bars, Jeremy Deverdun, François Molino, Bénédicte Maréchal, Marie-Christine Picot, Xavier Ayrignac, Clarisse Carra, Luc Bauchet, Alexandre Krainik, Pierre Labauge, Nicolas Menjot de Champfleur
OBJECTIVE: The link between cerebral vasoreactivity and cognitive status in multiple sclerosis remains unclear. The aim of the present study was to investigate a potential decrease of cerebral vasoreactivity in multiple sclerosis patients and correlate it with cognitive status. METHODS: Thirty-three patients with multiple sclerosis (nine progressive and 24 remitting forms, median age: 39 years, 12 males) and 22 controls underwent MRI with a hypercapnic challenge to assess cerebral vasoreactivity and a neuropsychological assessment...
October 12, 2017: European Radiology
https://www.readbyqxmd.com/read/29026292/the-effects-of-holistic-health-group-interventions-on-improving-the-cognitive-ability-of-persons-with-mild-cognitive-impairment-a-randomized-controlled-trial
#16
Kim-Wan Young, Petrus Ng, Timothy Kwok, Daphne Cheng
PURPOSE: Persons with mild cognitive impairment (PwMCI) are at a higher risk of developing dementia than those without cognitive impairment. This research study aims to evaluate the effectiveness of a holistic health group intervention, which is based on the holistic brain health approach as well as an Eastern approach to health care, on improving the cognitive ability of Chinese PwMCI. RESEARCH METHODS: In a randomized controlled trial (RCT), 38 Chinese PwMCI were randomly assigned to either a 10-session holistic health intervention group or the control group...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29025866/declining-levels-of-functionally-specialized-synaptic-proteins-in-plasma-neuronal-exosomes-with-progression-of-alzheimer-s-disease
#17
Edward J Goetzl, Erin L Abner, Gregory A Jicha, Dimitrios Kapogiannis, Janice B Schwartz
Interactions of the presynaptic proteins, neuronal pentraxin 2 (NPTX2) and neurexin 2α (NRXN2α), with their respective postsynaptic functional partners, GluA4-containing glutamate (AMPA4) receptor and neuroligin 1 (NLGN1), enhance excitatory synaptic activity in some areas of the hippocampus and cerebral cortex. As early damage of such excitatory circuits in the brain tissues of participants with Alzheimer's disease (AD) correlates with cognitive losses, plasma neuron-derived exosome (NDE) levels of these 2 pairs of specialized synaptic proteins were quantified to assess their biomarker characteristics...
October 12, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29024962/age-related-changes-in-headache-days-across-the-cognitive-spectrum
#18
Karl Echiverri, Gregory A Jicha, Jonathan H Smith
Introduction: Prior studies demonstrating age-related declines in headache prevalence have not accounted for the potentially confounding effects of cognitive impairment. Our primary goal was to assess the relationship between aging and self-reported monthly headache days across the cognitive spectrum. Methods: A detailed headache questionnaire was included prospectively as part of an annual mailing to participants in the Sanders-Brown Center on Aging longitudinal cohort...
August 4, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29024113/stress-related-cortisol-responsivity-modulates-prospective-memory
#19
Katharina Glienke, Martina Piefke
It is known that there is interindividual variation in behavioral and physiological stress reactions to the same stressor. The present study aimed at examining the impact of cortisol responsivity on performance in a complex real life-like prospective memory (PM) paradigm by a reanalysis of data published previously with the focus on the taxonomy of cognitive dimensions of PM. 21 male subjects were stressed with the Socially Evaluated Cold Pressor Test (SECPT) before the planning of intentions. Another group of 20 males underwent a control procedure...
October 10, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29021353/longitudinal-decline-of-driving-safety-in-parkinson-disease
#20
Ergun Y Uc, Matthew Rizzo, Amy M J O'Shea, Steven W Anderson, Jeffrey D Dawson
OBJECTIVE: To longitudinally assess and predict on-road driving safety in Parkinson disease (PD). METHODS: Drivers with PD (n = 67) and healthy controls (n = 110) drove a standardized route in an instrumented vehicle and were invited to return 2 years later. A professional driving expert reviewed drive data and videos to score safety errors. RESULTS: At baseline, drivers with PD performed worse on visual, cognitive, and motor tests, and committed more road safety errors compared to controls (median PD 38...
October 11, 2017: Neurology
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