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https://www.readbyqxmd.com/read/29667314/the-diary-of-a-nonagenarian-centenarian-woman-with-dementia-memory-loss-life-changes-and-community-care-in-japan
#1
Sayuri Suwa, Saori Otani, Mayuko Tsujimura, Kotoko Nogawa, Yoko Shiya
AIM: This study aimed to explore the experiences and thoughts of a nonagenarian-centenarian woman with dementia living alone, through detailed analysis of her unsolicited diary. DATA SOURCE: After receiving consent from Aki (a pseudonym), her family and caregivers, copies of her diaries, hand-written in Japanese, were provided for analysis. METHODS: The content of the diaries was broadly organized into themes and qualitative content analysis carried out for each theme along a sequential timeline...
April 2018: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/29667168/cognitive-decline-and-older-driver-crash-risk
#2
Laura A Fraade-Blanar, Beth E Ebel, Eric B Larson, Jeanne M Sears, Hilaire J Thompson, Kwun Chuen G Chan, Paul K Crane
OBJECTIVES: To examine automobile crash risk associated with cognition in older drivers without dementia. DESIGN: Retrospective secondary analysis of longitudinal cohort study. SETTING: Our study used data from the Adult Changes in Thought (ACT) Study merged with Washington State crash reports and licensure records. Data were available from 2002 to 2015. PARTICIPANTS: Group Health enrollees from Washington State aged 65 and older with active driver's licenses (N=2,615)...
April 17, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29667159/physical-activity-throughout-the-adult-life-span-and-domain-specific-cognitive-function-in-old-age-a-systematic-review-of-cross-sectional-and-longitudinal-data
#3
REVIEW
Tobias Engeroff, Tobias Ingmann, Winfried Banzer
BACKGROUND: A growing body of literature suggests that physical activity might alleviate the age-related neurodegeneration and decline of cognitive function. However, most of this evidence is based on data investigating the association of exercise interventions or current physical activity behavior with cognitive function in elderly subjects. OBJECTIVE: We performed a systematic review and hypothesize that physical activity during the adult life span is connected with maintained domain-specific cognitive functions during late adulthood defined as age 60+ years...
April 17, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29666388/the-cognitive-complexity-of-concurrent-cognitive-motor-tasks-reveals-age-related-deficits-in-motor-performance
#4
Anderson Souza Oliveira, Mikkel Staall Reiche, Cristina Ioana Vinescu, Sif Amalie Halkjær Thisted, Carina Hedberg, Miguel Nobre Castro, Martin Gronbech Jørgensen
Aging reduces cognitive functions, and such impairments have implications in mental and motor performance. Cognitive function has been recently linked to the risk of falls in older adults. Physical activities have been used to attenuate the declines in cognitive functions and reduce fall incidence, but little is known whether a physically active lifestyle can maintain physical performance under cognitively demanding conditions. The aim of this study was to verify whether physically active older adults present similar performance deficits during upper limb response time and precision stepping walking tasks when compared to younger adults...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29665875/global-cerebrovascular-burden-and-long-term-clinical-outcomes-in-asian-elderly-across-the-spectrum-of-cognitive-impairment
#5
Xin Xu, Yiong Huak Chan, Qun Lin Chan, Bibek Gyanwali, Saima Hilal, Boon Yeow Tan, Mohammad Kamran Ikram, Narayanaswamy Venketasubramanian, Christopher Li-Hsian Chen
ABSTRACTBackground/Aim:To investigate the predictive ability of the previously established global cerebrovascular disease (CeVD) burden scale on long-term clinical outcomes in a longitudinal study of Asian elderly participants across the spectrum of cognitive impairment. METHODS: A case-control study was conducted over a 2-year period involving participants with no cognitive impairment, cognitive impairment-no dementia (CIND), and Alzheimer's disease (AD). Annually, cognitive function was assessed with a comprehensive neuropsychological battery and the clinical dementia rating (CDR) scale was used to stage disease severity...
April 18, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29665854/a-community-based-physical-activity-intervention-to-prevent-mobility-related-disability-for-retired-older-people-retirement-in-action-react-study-protocol-for-a-randomised-controlled-trial
#6
Afroditi Stathi, Janet Withall, Colin J Greaves, Janice L Thompson, Gordon Taylor, Antonieta Medina-Lara, Colin Green, James Bilzon, Selena Gray, Heidi Johansen-Berg, Claire E Sexton, Max J Western, Jolanthe L de Koning, Jessica C Bollen, Sarah J Moorlock, Naiara Demnitz, Poppy Seager, Jack M Guralnik, W Jack Rejeski, Ken R Fox
BACKGROUND: The REtirement in ACTion (REACT) study is a multi-centre, pragmatic, two-arm, parallel-group randomised controlled trial (RCT) with an internal pilot phase. It aims to test the effectiveness and cost-effectiveness of a community, group-based physical activity intervention for reducing, or reversing, the progression of functional limitations in older people who are at high risk of mobility-related disability. METHODS/DESIGN: A sample of 768 sedentary, community-dwelling, older people aged 65 years and over with functional limitations, but who are still ambulatory (scores between 4 and 9 out of 12 in the Short Physical Performance Battery test (SPPB)) will be randomised to receive either the REACT intervention, delivered over a period of 12 months by trained facilitators, or a minimal control intervention...
April 17, 2018: Trials
https://www.readbyqxmd.com/read/29665283/accelerated-executive-functions-decline-and-gray-matter-structural-changes-in-middle-aged-type-1-diabetes-patients-with-proliferative-retinopathy
#7
Eelco van Duinkerken, Martijn D Steenwijk, Martin Klein, Frederik Barkhof, Daniel C Mograbi, Michaela Diamant, Frank J Snoek, Richard G Ijzerman
BACKGROUND: The aim of this study was to determine trajectories of cognitive and cortical changes over time in middle-aged patients with type 1 diabetes and proliferative retinopathy. METHODS: Twenty-five patients and 25 controls underwent neuropsychological assessment and neuroimaging twice in 3.56 ± 0.65 and 3.94 ± 0.91 years respectively (P = 0.098). Cognitive assessment included the domains of general cognitive ability, memory, information processing speed, executive functions, attention, motor and psychomotor speed...
April 17, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29665124/how-does-dementia-with-lewy-bodies-start-prodromal-cognitive-changes-in-rem-sleep-behavior-disorder
#8
Daphné Génier Marchand, Ronald B Postuma, Frédérique Escudier, Jessie De Roy, Amélie Pelletier, Jacques Montplaisir, Jean-François Gagnon
Objective We describe the progression of cognitive decline and identify the predictive values of cognitive tests in three groups of REM sleep behavior disorder (RBD) patients classified at their last follow-up as having Parkinson's disease (PD), dementia with Lewy bodies (DLB), or still-idiopathic. Methods Patients (n=109) underwent polysomnographic, neurological, and neuropsychological assessments. We used linear mixed-model analyses to compare the progression of cognitive test performance between the three groups over a three-year prodromal period, and performed linear regressions for a six-year prodromal period...
April 17, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29665066/serotonin-beta-amyloid-and-cognition-in-parkinson-disease
#9
Vikas Kotagal, Cathie Spino, Nicolaas I Bohnen, Robert A Koeppe, Roger L Albin
OBJECTIVE: Serotoninergic neurotransmission may modulate beta-amyloid peptide (Aβ) metabolism through up-regulation of alpha-secretase. Early Parkinson disease (PD) shows variable serotoninergic denervation, which may impact Aβ deposition. METHODS: We conducted three analyses to explore associations between serotoninergic neurotransmission and cerebral Aβ burden in PD. The first was a cross-sectional imaging study of PD subjects (n=23) using the serotoninergic transporter positron emission tomography (PET) ligand [11 C]DASB and amyloid PET Pittsburgh compound B ([11 C]PiB)...
April 17, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29663942/longitudinal-anthropometric-assessment-of-rhesus-macaque-macaca-mulatta-model-of-huntington-disease
#10
Carissa E Hunter, Alvince L Pongos, Tim Y Chi, Christa Payne, Fawn C Stroud, Anthony W S Chan
The neurodegeneration associated with Huntington disease (HD) leads to the onset of motor and cognitive impairment and their advancement with increased age in humans. In children at risk for HD, body measurement growth abnormalities include a reduction in BMI, weight, height, and head circumference. The transgenic HD NHP model was first reported in 2008, and progressive decline in cognitive behaviors and motor impairment have been reported. This study focuses on longitudinal body measurements in HD macaques from infancy through adulthood...
April 2, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29663261/evaluation-of-diffusion-tensor-imaging-changes-and-neurocognitive-effects-of-asymptomatic-vitamin-b12-deficiency
#11
Ali Zeynal Abidin Tak, Erdal Dayan, Hacı Taner Bulut
Vitamin B12 plays an important role in the mechanisms which are responsible for myelinization in the central nervous system. It can particularly lead to hematological and neuropsychiatric symptoms when serum levels fall due to insufficient intake with diet or absorption problems. The purpose of this study was to show the cognitive effects in vitamin B12 deficiency cases that have not reached clinical symptom level using neuropsychological tests, and to show possible cerebral neuronal damage using diffusion tensor imaging (DTI) method...
April 16, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29663137/health-related-quality-of-life-among-cancer-patients-in-their-last-year-of-life-results-from-the-profiles-registry
#12
Natasja J H Raijmakers, M Zijlstra, J van Roij, O Husson, S Oerlemans, L V van de Poll-Franse
PURPOSE: The aim of this study was to assess health-related quality of life (HRQoL) in the last year of life of cancer patients stratified by four periods of time before death. PATIENTS AND METHODS: Between 2008 and 2015, cancer patients were invited to participate in PROFILES (Patient Reported Outcomes Following Initial Treatment and Long-term Evaluation of Survivorship) registry studies. Patients were eligible for inclusion in this secondary analysis if they had been invited to complete the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) in their last year of life (N = 892)...
April 16, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29662895/heme-oxygenase-1-activity-as-a-correlate-to-exercise-mediated-amelioration-of-cognitive-decline-and-neuropathological-alterations-in-an-aging-rat-model-of-dementia
#13
Andrea Kurucz, Mariann Bombicz, Rita Kiss, Dániel Priksz, Balázs Varga, Tibor Hortobágyi, György Trencsényi, Renáta Szabó, Anikó Pósa, Rudolf Gesztelyi, Zoltán Szilvássy, Béla Juhász
Alzheimer's disease (AD) is a neurodegenerative disorder with cognitive impairment. Physical exercise has long been proven to be beneficial in the disorder. The present study was designed to examine the effect of voluntary exercise on spatial memory, imaging, and pathological abnormalities. Particular focus has been given to the role of heme oxygenase-1 (HO-1)-an important cellular cytoprotectant in preserving mental acuity-using an aging rat model of dementia. Male and female Wistar rats were segregated into six groups-namely, (i) aged sedentary (control) females (ASF, n = 8); (ii) aged sedentary (control) males (ASM, n = 8); (iii) aged running females (ARF, n = 8); (iv) aged running males (ARM, n = 8); (v) young control females (YCF, n = 8); and (vi) young control males (YCM, n = 8)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29661560/observational-prospective-natural-history-of-patients-with-sanfilippo-syndrome-type-b
#14
Chester B Whitley, Maureen Cleary, Karl Eugen Mengel, Paul Harmatz, Elsa Shapiro, Igor Nestrasil, Patrick Haslett, David Whiteman, David Alexanderian
OBJECTIVE: To evaluate the natural course of disease progression in patients with Sanfilippo syndrome type B (mucopolysaccharidosis type IIIB), identify potential end points for future therapy trials, and characterize biomarkers related to the disease. STUDY DESIGN: A prospective, multicenter study was conducted. Baseline, 6-month, and 12-month assessments included neurodevelopmental status (Bayley Scales of Infant Development, Third edition), adaptive status (Vineland Adaptive Behavior Scales, Second Edition), volumetric brain magnetic resonance imaging, cerebrospinal fluid heparan sulfate, and urine glycosaminoglycan (GAG) measurements...
April 13, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29661156/synergic-trial-synchronizing-exercises-remedies-in-gait-and-cognition-a-multi-centre-randomized-controlled-double-blind-trial-to-improve-gait-and-cognition-in-mild-cognitive-impairment
#15
Manuel Montero-Odasso, Quincy J Almeida, Amer M Burhan, Richard Camicioli, Julien Doyon, Sarah Fraser, Karen Li, Teresa Liu-Ambrose, Laura Middleton, Susan Muir-Hunter, William McIlroy, José A Morais, Frederico Pieruccini-Faria, Kevin Shoemaker, Mark Speechley, Akshya Vasudev, G Y Zou, Nicolas Berryman, Maxime Lussier, Leanne Vanderhaeghe, Louis Bherer
BACKGROUND: Physical exercise, cognitive training, and vitamin D are low cost interventions that have the potential to enhance cognitive function and mobility in older adults, especially in pre-dementia states such as Mild Cognitive Impairment (MCI). Aerobic and progressive resistance exercises have benefits to cognitive performance, though evidence is somewhat inconsistent. We postulate that combined aerobic exercise (AE) and progressive resistance training (RT) (combined exercise) will have a better effect on cognition than a balance and toning control (BAT) intervention in older adults with MCI...
April 16, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29660935/effect-of-cilostazol-on-incident-dementia-in-elderly-men-and-women-with-ischemic-heart-disease
#16
Mi-Young Kim, Yoojin Noh, Sang Joon Son, Sooyoung Shin, Hee-Young Paik, Sukhyang Lee, Yi-Sook Jung
BACKGROUND: Ischemic heart disease (IHD) is associated with cognitive decline and may contribute to an increased risk of dementia. OBJECTIVE: The goal of the present study was to investigate whether cilostazol use is associated with a lower risk of incident dementia in Asian patients with IHD, and whether these effects differed based on sex. METHODS: This retrospective cohort study was performed using the Korean National Insurance Claim Data of the Health Insurance Review and Assessment Service; the duration of the study was from January 1, 2007 to December 31, 2015...
April 11, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29660087/older-adults-pay-an-additional-cost-when-texting-and-walking-effects-of-age-environment-and-use-of-mixed-reality-on-dual-task-performance
#17
Tal Krasovsky, Patrice L Weiss, Rachel Kizony
Background: Texting while walking (TeWW) has become common among people of all ages, and mobile phone use during gait is increasingly associated with pedestrian injury. Although dual-task walking performance is known to decline with age, data regarding the effect of age on dual-task performance in ecological settings are limited. Objective: The objective of this study was to evaluate the effect of age, environment (indoors/outdoors), and mixed reality (merging of real and virtual environments) on TeWW performance...
April 6, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29653338/long-term-effects-of-adjunctive-perampanel-on-cognition-in-adolescents-with-partial-seizures
#18
Jesus E Piña-Garza, Lieven Lagae, Vicente Villanueva, J Ben Renfroe, Antonio Laurenza, Betsy Williams, Dinesh Kumar, Kimford J Meador
OBJECTIVE: The aim of this study was to evaluate long-term effects of adjunctive perampanel on cognition, efficacy, growth, safety, and tolerability in adolescents with inadequately controlled partial seizures. METHODS: Study 235, a multicenter, randomized, double-blind, placebo-controlled, parallel-group, Phase II study with an open-label extension phase (NCT01161524), was primarily designed to assess the effects of adjunctive perampanel on cognition. Patients (aged ≥12 to <18years) had a diagnosis of epilepsy with inadequately controlled partial seizures, with or without secondary generalization, despite receiving 1-3 antiepileptic drugs...
April 10, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29644921/cognitive-frailty-and-its-association-with-all-cause-mortality-among-community-dwelling-older-adults-in-taiwan-results-from-i-lan-longitudinal-aging-study
#19
Li-Kuo Liu, Wei-Ju Lee, Yi-Hui Wu, An-Chun Hwang, Ming-Hsien Lin, Hiroyuki Shimada, Li-Ning Peng, Ching-Hui Loh, Hidenori Arai, Liang-Kung Chen
BACKGROUND: The definition of cognitive frailty and its prediction for adverse outcome of community-living older adults remains controversial. This study aims to evaluate the association between cognitive frailty and all-cause mortality among community-living older adults. METHODS: Data of the I-Lan Longitudinal Aging Study (ILAS) were retrieved for study. Frailty was defined by Fried's criteria, and a series of neuropsychological assessments, including the Mini-Mental State Examination (MMSE), Center for Epidemiology Studies-Depression (CES-D), the delay free recall in the Chinese Version Verbal Learning Test, the Boston Naming Test, the category (animal) Verbal Fluency Test, the Taylor Complex Figure Test, the digital backward and the Clock Drawing Test were performed...
April 12, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29643802/the-beneficial-effects-of-cognitive-training-with-simple-calculation-and-reading-aloud-scra-in-the-elderly-postoperative-population-a-pilot-randomized-controlled-trial
#20
Kay Kulason, Rui Nouchi, Yasushi Hoshikawa, Masafumi Noda, Yoshinori Okada, Ryuta Kawashima
Background: There has been little research conducted regarding cognitive treatments for the elderly postsurgical population. Patients aged ≥60 years have an increased risk of postoperative cognitive decline, a condition in which cognitive functions are negatively affected. This cognitive decline can lead to a decline in quality of life. In order to maintain a high quality of life, the elderly postsurgical population may benefit from treatment to maintain and/or improve their cognitive functions. This pilot study investigates the effect of simple calculation and reading aloud (SCRA) cognitive training in elderly Japanese postsurgical patients...
2018: Frontiers in Aging Neuroscience
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