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https://www.readbyqxmd.com/read/29456872/accuracy-in-local-staging-of-prostate-cancer-by-adding-a-three-dimensional-t2-weighted-sequence-with-radial-reconstructions-in-magnetic-resonance-imaging
#1
Fredrik Jäderling, Tommy Nyberg, Michael Öberg, Stefan Carlsson, Mikael Skorpil, Lennart Blomqvist
Background: The evidence supporting the use of magnetic resonance imaging (MRI) in prostate cancer detection has been established, but its accuracy in local staging is questioned. Purpose: To investigate the additional value of multi-planar radial reconstructions of a three-dimensional (3D) T2-weighted (T2W) MRI sequence, intercepting the prostate capsule perpendicularly, for improving local staging of prostate cancer. Material and Methods: Preoperative, bi-parametric prostate MRI examinations in 94 patients operated between June 2014 and January 2015 where retrospectively reviewed by two experienced abdominal radiologists...
February 2018: Acta Radiologica Open
https://www.readbyqxmd.com/read/29446508/accelerated-t-2-mapping-combining-parallel-mri-and-model-based-reconstruction-grappatini
#2
Tom Hilbert, Tilman J Sumpf, Elisabeth Weiland, Jens Frahm, Jean-Philippe Thiran, Reto Meuli, Tobias Kober, Gunnar Krueger
BACKGROUND: Quantitative T 2 measurements are sensitive to intra- and extracellular water accumulation and myelin loss. Therefore, quantitative T 2 promises to be a good biomarker of disease. However, T 2 measurements require long acquisition times. PURPOSE: To accelerate T 2 quantification and subsequent generation of synthetic T 2 -weighted (T 2 -w) image contrast for clinical research and routine. To that end, a recently developed model-based approach for rapid T 2 and M 0 quantification (MARTINI) based on undersampling k-space, was extended by parallel imaging (GRAPPA) to enable high-resolution T 2 mapping with access to T 2 -w images in less than 2 minutes acquisition time for the entire brain...
February 15, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29443386/technical-note-error-metrics-for-estimating-the-accuracy-of-needle-instrument-placement-during-transperineal-mr-us-guided-prostate-interventions
#3
Ester Bonmati, Yipeng Hu, Barbara Villarini, Rachael Rodell, Paul Martin, Lianghao Han, Ian Donaldson, Hashim U Ahmed, Caroline M Moore, Mark Emberton, Dean C Barratt
PURPOSE: Image-guided systems that fuse magnetic resonance imaging (MRI) with three-dimensional (3D) ultrasound (US) images for performing targeted prostate needle biopsy and minimally-invasive treatments for prostate cancer are of increasing clinical interest. To date, a wide range of different accuracy estimation procedures and error metrics have been reported, which makes comparing the performance of different systems difficult. METHODS: A set of 9 measures are presented to assess the accuracy of MRI-US image registration, needle positioning, needle guidance, and overall system error, with the aim of providing a methodology for estimating the accuracy of instrument placement using a MR/US-guided transperineal approach...
February 14, 2018: Medical Physics
https://www.readbyqxmd.com/read/29438586/progression-and-treatment-rates-using-an-active-surveillance-protocol-incorporating-image-guided-baseline-biopsies-and-multi-parametric-mri-monitoring-for-men-with-favourable-risk-prostate-cancer
#4
David Thurtle, Tristan Barrett, Vineetha Thankappan-Nair, Brendan Koo, Anne Warren, Christof Kastner, Kasra Saeb-Parsy, Jenna Kimberley-Duffell, Vincent J Gnanapragasam
OBJECTIVE: To assess early outcomes since the introduction of an active surveillance (AS) protocol incorporating mpMRI guided baseline biopsies and image based surveillance. PATIENTS AND METHODS: A new AS protocol mandating image-guided baseline biopsies, annual mpMRI and 3 monthly PSA but which retained protocol re-biopsies was tested. Pathological progression, treatment conversion and triggers for non-protocol biopsy were recorded prospectively. RESULTS: Data from 157 men enrolled on this protocol (median: age 64years, PSA 6...
February 13, 2018: BJU International
https://www.readbyqxmd.com/read/29437268/using-support-vector-machine-analysis-to-assess-partinmr-a-new-prediction-model-for-organ-confined-prostate-cancer
#5
Jing Wang, Chen-Jiang Wu, Mei-Ling Bao, Jing Zhang, Hai-Bin Shi, Yu-Dong Zhang
BACKGROUND: Partin tables represent the most widely used predictive tool for prostate cancer stage at prostatectomy but with potential limitations. PURPOSE: To develop a new PartinMR model for organ-confined prostate cancer (OCPCA) by incorporating Partin table and mp-MRI with a support vector machine (SVM) analysis. STUDY TYPE: Retrospective. POPULATION: In all, 541 patients with biopsy-confirmed prostate cancer underwent mp-MRI...
February 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29436852/comparing-photon-and-proton-based-hypofractioned-sbrt-for-prostate-cancer-accounting-for-robustness-and-realistic-treatment-deliverability
#6
Lee Goddard, Nils P Brodin, William R Bodner, Madhur Garg, Wolfgang A Tomé
OBJECTIVE: To investigate whether photon or proton based SBRT is the preferred modality for high dose hypofractionation prostate cancer treatment. Achievable dose distributions were compared when uncertainties in target positioning and range uncertainties were appropriately accounted for. METHODS: Ten patients with prostate cancer previously treated at our institution with photon SBRT using volumetric modulated arc therapy (VMAT) were identified. MRI images fused to the treatment planning CT allowed for accurate target and organ-at-risk (OAR) delineation...
February 13, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29432339/18f-choline-pet-mr-can-detect-and-delineate-local-recurrence-after-high-intensity-focused-ultrasound-therapy-of-prostate-cancer
#7
Irene A Burger, Andrei Gafita, Julian Müller, Benedikt Kranzbühler, Olivio F Donati, Daniel Eberli
Restaging local recurrence after high-intensity focused ultra-sound (HIFU) is based on multiparametric MRI (mpMRI). However, postinterventional changes of the tissue, such as edema or hemorrhage, are limiting tumor detection on mpMRI. We present a case of a rising prostate-specific antigen values, negative mpMRI, and a Gleason score of 4+4 on template biopsy after HIFU. On F-choline PET/MR, high focal uptake was detected at the location of positive biopsy. Re-HIFU based on the fused F-choline PET/MR images was performed, followed by a recurrence-free period of 11 months...
February 9, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29428316/variability-induced-by-the-mr-imager-in-dynamic-contrast-enhanced-imaging-of-the-prostate
#8
S Brunelle, C Zemmour, F Bratan, F Mège-Lechevallier, A Ruffion, M Colombel, S Crouzet, A Sarran, O Rouvière
PURPOSE: To evaluate the variability induced by the imager in discriminating high-grade (Gleason≥7) prostate cancers (HGC) using dynamic contrast-enhanced MRI. MATERIAL AND METHODS: We retrospectively selected 3T MRIs with temporal resolution<10 seconds and comprising T1 mapping from a prospective radiologic-pathologic database of patients treated by prostatectomy. Ktrans, Kep, Ve and Vp were calculated for each lesion seen on MRI using the Weinmann arterial input function (AIF) and three patient-specific AIFs measured in the right and left iliac arteries in pixels in the center of the lumen (psAIF-ST) or manually selected by two independent readers (psAIF-R1 and psAIF-R2)...
February 7, 2018: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29428182/online-interactive-case-based-instruction-in-prostate-magnetic-resonance-imaging-interpretation-using-prostate-imaging-and-reporting-data-system-version-2-effect-for-novice-readers
#9
Andrew B Rosenkrantz, Jovan Begovic, Antonio Pires, Eugene Won, Samir S Taneja, James S Babb
PURPOSE: To assess the effect on reader performance of an interactive case-based online tutorial for prostate magnetic resonance imaging (MRI) interpretation using Prostate Imaging and Reporting Data System (PI-RADS). METHODS: An educational website was developed incorporating scrollable multiparametric prostate MRI examinations with annotated solutions based on PI-RADS version 2. Three second-year radiology residents evaluated a separate set of 60 prostate MRI examinations both before and after review of the online case material, identifying and scoring dominant lesions...
January 10, 2018: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29425221/18f-fluorocholine-pet-ct-in-patients-with-occult-biochemical-recurrence-of-prostate-cancer-detection-rate-impact-on-management-and-adequacy-of-impact-a-prospective-multicentre-study
#10
Quentin Gillebert, Virginie Huchet, Caroline Rousseau, Alexandre Cochet, Pierre Olivier, Frédéric Courbon, Eric Gontier, Valérie Nataf, Sona Balogova, Jean-Noël Talbot
AIM: To prospectively evaluate the clinical impact and the diagnostic performance of FCH-PET/CT in patients with occult biochemical recurrence of prostate cancer (PCa). MATERIALS AND METHODS: Results of 179 patients (mean PSA = 7.5ng/mL) with negative/inconclusive results of pelvic-MRI and of bone-scintigraphy were analysed. To determine the impact of FCH-PET/CT on diagnostic thinking and on patient management, the referring physicians prospectively filled-in a 1st and 2nd questionnaire related to patient's planned management before and after FCH-PET/CT...
2018: PloS One
https://www.readbyqxmd.com/read/29420978/multiparametric-mr-imaging-of-the-prostate-interpretation-including-prostate-imaging-reporting-and-data-system-version-2
#11
REVIEW
Alessandro Furlan, Amir A Borhani, Antonio C Westphalen
mp-MRI of the prostate is a complex study that combines anatomic and functional imaging. The complexity of this technique, along with an increasing demand, has brought new challenges to imaging interpretation. The Prostate Imaging Reporting and Data System provides radiologists with guidelines to standardize interpretation. This article discusses the interpretation of the pulse sequences recommended in the Prostate Imaging Reporting and Data System version 2 guidelines, reviews advanced quantitative imaging tools, and discusses future directions...
March 2018: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/29410202/evolving-utilization-of-pre-biopsy-prostate-mri-in-the-medicare-population
#12
Andrew B Rosenkrantz, Jennifer Hemingway, Danny R Hughes, Richard Duszak, Bibb Allen, Jeffrey C Weinreb
PURPOSE: To assess changing utilization of pre-biopsy prostate MRI in Medicare beneficiaries. MATERIALS AND METHODS: Men undergoing prostate biopsy were identified in 5% Medicare Research Identifiable Files from October 2010 through September 2015. Rates of pre-biopsy prostate MRI (any pelvic MRI ≤6 months before biopsy with a prostate indication diagnosis code) were assessed. Temporal changes and variation by geography and among populations were determined. RESULTS: In male Medicare beneficiaries, pre-biopsy MRI utilization rates increased from 0...
February 1, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29409824/68ga-psma-pet-ct-for-primary-diagnosis-of-prostate-cancer-in-men-with-contraindications-to-or-negative-mpmri-a-prospective-observational-study
#13
Egesta Lopci, Alberto Saita, Massimo Lazzeri, Giovanni Lughezzani, Piergiuseppe Colombo, Nicolò Maria Buffi, Rodolfo Hurle, Katia Marzo, Roberto Peschechera, Alessio Benetti, Silvia Zandegiacomo, Luisa Pasini, Giuliana Lista, Pasquale Cardone, Angelo Castello, Davide Maffei, Luca Balzarini, Arturo Chiti, Giorgio Guazzoni, Paolo Casale
BACKGROUND: 68Ga-PSMA PET/CT may represent the most promising imaging modality for identification and risk stratification of prostate cancer (PCa) in patients with contraindications to or negative multiparametric MRI (mpMRI). METHODS: This prospective observational study analyzed 68Ga-PSMA PET/CT in a selected group of patients with persistently elevated PSA and/or PHI (prostate health index) suspicious for PCa, negative digital rectal examination, and at least one negative biopsy...
January 31, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29408568/role-of-mri-targeted-biopsy-in-detection-of-prostate-cancer-harbouring-adverse-pathological-features-of-intraductal-carcinoma-and-invasive-cribriform-carcinoma
#14
Susan Prendeville, Mark Gertner, Manjula Maganti, Melania Pintilie, Nathan Perlis, Ants Toi, Andrew J Evans, Antonio Finelli, Theodorus H van der Kwast, Sangeet Ghai
PURPOSE: The aim of this study was to compare biopsy detection of intraductal (IDC) and cribriform (CR) pattern invasive prostate carcinoma (PCa) in mpMRI positive and negative regions of the prostate. MATERIAL AND METHODS: A prospectively maintained single institution database was queried to identify patients who underwent mpMRI/US fusion targeted biopsy (MRI-TBx) and concurrent systematic sextant biopsy of MRI negative regions (SMN-Bx) between January 2013 and May 2016...
January 31, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29407999/pilot-study-for-supervised-target-detection-applied-to-spatially-registered-multiparametric-mri-in-order-to-non-invasively-score-prostate-cancer
#15
Rulon Mayer, Charles B Simone, William Skinner, Baris Turkbey, Peter Choykey
BACKGROUND: Gleason Score (GS) is a validated predictor of prostate cancer (PCa) disease progression and outcomes. GS from invasive needle biopsies suffers from significant inter-observer variability and possible sampling error, leading to underestimating disease severity ("underscoring") and can result in possible complications. A robust non-invasive image-based approach is, therefore, needed. PURPOSE: Use spatially registered multi-parametric MRI (MP-MRI), signatures, and supervised target detection algorithms (STDA) to non-invasively GS PCa at the voxel level...
January 27, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29406411/robotics-in-mri-guided-interventions
#16
Nobuhiko Hata, Pedro Moreira, Gregory Fischer
Robots have been found to be a useful tool in magnetic resonance imaging (MRI)-guided intervention. The utility of robots in MRI-guided therapy ranges from aid for precision targeting to high-dexterity surgical tools to improve or even enable new MRI-guided therapy options. The objective of this article is to review the technical aspects of robotics in MRI-guided interventions, highlight the role of MRI robots in prostate interventions, and finally discuss the future contribution of emerging robotics technology useful in MRI-guided intervention...
February 2018: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/29405121/accuracy-and-precision-of-patient-positioning-for-pelvic-mr-only-radiation-therapy-using-digitally-reconstructed-radiographs
#17
Reko Kemppainen, Teuvo Vaara, Timo Joensuu, Timo Kiljunen
Background and Purpose Magnetic resonance imaging (MRI) has in recent years emerged as an imaging modality to drive precise contouring of targets and organs at risk in external beam radiation therapy. Moreover, recent advances in MRI enable treatment of cancer without computed tomography (CT) simulation. A commercially available MR-only solution, MRCAT, offers a single-modality approach that provides density information for dose calculation and generation of positioning reference images. We evaluated the accuracy of patient positioning based on MRCAT digitally reconstructed radiographs (DRRs) by comparing to standard CT based workflow...
February 6, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29401152/prostate-specific-membrane-antigen-pet-ct-incidental-finding-of-a-schwannoma
#18
André H Dias, Kirsten Bouchelouche
We describe a case of a 73-year-old man with newly diagnosed prostate cancer referred to Ga-PSMA PET/CT for staging. A focal uptake of PSMA was visualized in the prostate compatible with primary prostate cancer. Outside the prostate, a PSMA-avid paravertebral soft tissue mass was observed. Further investigation with MRI of the same region showed signs compatible with schwannoma. This case shows the importance of including schwannoma in the differential diagnostic evaluation of patients with Ga-PSMA-positive foci in paravertebral locations, as schwannomas may show avid PSMA uptake and may potentially lead to an incorrect diagnosis of metastasis...
February 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29394660/-neoadjuvant-chemoradiotherapy-for-locally-advanced-carcinoma-associated-with-anal-fistula
#19
Teppei Miyakawa, Satoru Iida, Takahiro Igaki, Hiroyuki Shiobara, Ryo Matsumoto, Katsutaka Mitachi, Yoshiteru Ohata, Katsumasa Saito, Tomoya Miura, Takumi Irie, Shigeru Yamazaki
The patient was a 59-year-old man. He was admitted to our hospital because of increasing anal pain with induration of the perianal region. There were large secondary orifices with mucous discharge on the left side of the perineal resion and buttock. We diagnosed adenocarcinoma on analysis of a biopsy specimen from induration of the perianal region. Pelvic CT and MRI showed that the tumor spreaded within the pelvis, with invasion of the prostate and sacrum. We performed neoadjuvant chemoradiotherapy preoperatively...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29393268/integrated-68gallium-labelled-prostate-specific-membrane-antigen-11-positron-emission-tomography-magnetic-resonance-imaging-enhances-discriminatory-power-of-multi-parametric-prostate-magnetic-resonance-imaging
#20
Mohammad Al-Bayati, Johannes Grueneisen, Susanne Lütje, Lino M Sawicki, Saravanabavaan Suntharalingam, Stephan Tschirdewahn, Michael Forsting, Herbert Rübben, Ken Herrmann, Lale Umutlu, Axel Wetter
PURPOSE: To evaluate diagnostic accuracy of integrated 68Gallium labelled prostate-specific membrane antigen (68Ga-PSMA)-11 positron emission tomography (PET)/MRI in patients with primary prostate cancer (PCa) as compared to multi-parametric MRI. MATERIAL AND METHODS: A total of 22 patients with recently diagnosed primary PCa underwent clinically indicated 68Ga-PSMA-11 PET/CT for initial staging followed by integrated 68Ga-PSMA-11 PET/MRI. Images of multi-parametric magnetic resonance imaging (mpMRI), PET and PET/MRI were evaluated separately by applying Prostate Imaging Reporting and Data System (PIRADSv2) for mpMRI and a 5-point Likert scale for PET and PET/MRI...
January 25, 2018: Urologia Internationalis
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