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https://www.readbyqxmd.com/read/29047455/a-monte-carlo-study-to-assess-the-effect-of-1-5-t-magnetic-fields-on-the-overall-robustness-of-pencil-beam-scanning-proton-radiotherapy-plans-for-prostate-cancer
#1
Christopher Kurz, Guillaume Landry, Andreas F Resch, George Dedes, Florian Kamp, Ute Ganswindt, Claus Belka, Bas W Raaymakers, Katia Parodi
Combining magnetic-resonance imaging (MRI) and proton therapy (PT) using pencil-beam scanning (PBS) may improve image-guided radiotherapy. We aimed at assessing the impact of a magnetic field on PBS-PT plan quality and robustness. Specifically, the robustness against anatomical changes and positioning errors in an MRI-guided scenario with a 30 cm radius 1.5 T magnetic field was studied for prostate PT. Five prostate cancer patients with three consecutive CT images (CT1-3) were considered. Single-field uniform dose PBS-PT plans were generated on the segmented CT1 with Monte-Carlo-based treatment planning software for inverse optimization...
October 19, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29046984/spatial-tracking-of-targeted-prostate-biopsy-locations-moving-towards-effective-focal-partial-prostate-gland-ablation-with-improved-treatment-planning
#2
REVIEW
Steven Sidelsky, Shaan Setia, Srinivas Vourganti
The ability to selectively characterize, localize, and predict the specific areas of the prostate gland which harbor the worst biologic behavior is requisite for optimal prostate cancer therapy, especially in the emerging field of partial prostate gland ablation (focal therapy). In this manuscript, we highlight contemporary techniques in target tracking for focal therapy planning. Multiparametric magnetic resonance imaging has emerged as a dominant strategy to localize biopsy sites most likely to contain high-grade lesions...
October 18, 2017: Current Urology Reports
https://www.readbyqxmd.com/read/29045185/apparent-diffusion-coefficient-values-of-prostate-cancer-comparison-of-2d-and-3d-rois
#3
Tsutomu Tamada, Chenchan Huang, Justin M Ream, Myles Taffel, Samir S Taneja, Andrew B Rosenkrantz
OBJECTIVE: The purpose of this study was to compare the reproducibility and diagnostic performance of 2D and 3D ROIs for prostate apparent diffusion coefficient (ADC) measurements. MATERIALS AND METHODS: The study included 56 patients with prostate cancer undergoing 3-T MRI including DWI (b = 50 and 1000 s/mm(2)) before radical prostatectomy. Histologic findings from prostatectomy specimens were reviewed to denote each patient's dominant tumor and a benign region with visually decreased ADC...
October 18, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29044630/fully-automatic-deformable-registration-of-pre-treatment-mri-ct-for-image-guided-prostate-radiotherapy-planning
#4
Iyas Hamdan, Julien Bert, Catherine Cheze Le Rest, Jean Pierre Tasu, Nicolas Boussion, Antoine Valeri, Guillaume Dardenne, Dimitris Visvikis
PURPOSE: In prostate radiotherapy, dose distribution may be calculated on CT images, while the MRI can be used to enhance soft tissue visualization. Therefore, a registration between MR and CT images could improve the overall treatment planning process, by improving visualization with a demonstrated inter-observer delineation variability when segmenting the prostate, which in turn can lead to a more precise planning. This registration must compensate for prostate deformations caused by changes in size and form between the acquisitions of both modalities...
October 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/29043385/whole-gland-prostate-cancer-cryoablation-with-magnetic-resonance-imaging-guidance-one-year-follow-up
#5
Kristin A Kinsman, Mariah L White, Lance A Mynderse, Akira Kawashima, Karen Rampton, Krzysztof R Gorny, Thomas D Atwell, Joel P Felmlee, Matthew R Callstrom, David A Woodrum
PURPOSE: Patients who develop prostate cancer after prior abdominal perineal resection are poor surgical candidates, and have limited treatment options. Therefore, our goal is to present results from a single institutional experience of four patients who underwent whole gland MRI-guided cryoablation with a history complicated by prior abdominoperineal resection. MATERIALS AND METHODS: Four MRI-guided cryoablative treatments (mean age 64, range 59-69 years) for primary and locally recurrent prostate adenocarcinoma were retrospectively reviewed in patients with prior abdominal perineal resection for colorectal cancer (3) and juvenile polyposis (1)...
October 17, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29039785/prospective-comparison-of-f-18-choline-pet-ct-scan-versus-axial-mri-for-detecting-bone-metastasis-in-biochemically-relapsed-prostate-cancer-patients
#6
Wouter Huysse, Frédéric Lecouvet, Paolo Castellucci, Piet Ost, Valerie Lambrecht, Carlos Artigas, Marie-Laurence Denis, Kathia De Man, Louke Delrue, Lennart Jans, Aurélie De Bruycker, Filip De Vos, Gert De Meerleer, Karel Decaestecker, Valerie Fonteyne, Bieke Lambert
We compared fluor-18 choline positron emission tomography/computed tomography (PET/CT) and axial skeleton magnetic resonance imaging (MRI) prospectively obtained for the detection of bone metastases in non-castrated patients with biochemically recurrent prostate cancer following primary treatment. PET/CT was performed 45 min post-injection of 3-4 MBq/kg F-18 methyl choline. MRI included T1- and fluid sensitive T2-weighted images of the spine and pelvis. Readers were initially blinded from other results and all scans underwent independent double reading...
October 17, 2017: Diagnostics
https://www.readbyqxmd.com/read/29038888/simultaneous-whole-body-18-f-psma-1007-pet-mri-with-integrated-high-resolution-multiparametric-imaging-of-the-prostatic-fossa-for-comprehensive-oncological-staging-of-patients-with-prostate-cancer-a-pilot-study
#7
Martin T Freitag, Claudia Kesch, Jens Cardinale, Paul Flechsig, Ralf Floca, Matthias Eiber, David Bonekamp, Jan P Radtke, Clemens Kratochwil, Klaus Kopka, Markus Hohenfellner, Albrecht Stenzinger, Heinz-Peter Schlemmer, Uwe Haberkorn, Frederik Giesel
INTRODUCTION: The aim of the present study was to explore the clinical feasibility and reproducibility of a comprehensive whole-body (18)F-PSMA-1007-PET/MRI protocol for imaging prostate cancer (PC) patients. METHODS: Eight patients with high-risk biopsy-proven PC underwent a whole-body PET/MRI (3 h p.i.) including a multi-parametric prostate MRI after (18)F-PSMA-1007-PET/CT (1 h p.i.) which served as reference. Seven patients presented with non-treated PC, whereas one patient presented with biochemical recurrence...
October 16, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29036003/68ga-prostate-specific-membrane-antigen-avid-tubercular-lesions-mimicking-prostate-cancer-metastasis-on-simultaneous-prostate-specific-membrane-antigen-pet-mri
#8
Aashim Ahuja, Sangeeta Taneja, Kiran Thorat, Amarnath Jena
Ga-prostate-specific membrane antigen (PSMA) has gained increasing interest as a target molecule in imaging of prostate cancer because of its selective overexpression in local prostate cancer lesions and metastasis. We report a case of a 62-year-old man with raised serum prostate-specific antigen levels who presented for Ga-PSMA HBED-CC simultaneous PET/MRI for prostate cancer evaluation. A PSMA-nonavid PI-RADS 5 (Prostate Imaging-Reporting and Data System) lesion was confirmed as adenocarcinoma on histopathology...
October 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29035995/internal-auditory-canal-tumor-as-an-incidental-finding-on-a-choline-pet-ct-scan-in-a-prostate-cancer-patient
#9
Julia Malamitsi, Roxanni Efthymiadou, Theodore Pipikos, Fani Vlachou, Vassilis Prassopoulos
An 84-year-old man with a history of prostate cancer, treated with radiotherapy, presented with an increase in PSA levels. F-choline PET/CT showed foci of increased choline uptake in L4 and L5 vertebrae, suggestive of bone metastases and another focus in the right cerebellopontine angle. A brain MRI revealed a focus of intense contrast enhancement in the same region, consistent with an acoustic neuroma.
October 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29035994/prostate-specific-membrane-antigen-in-low-grade-fibromatosis
#10
Ramin Akbarian Aghdam, Masoumeh Hakiminejad, Hamidreza Hashemifard, Azadeh Rakhshan, Elahe Pirayesh
We report a case of fibromatosis demonstrating prostate-specific membrane antigen (PSMA)-positive scan. A 76-year-old man was under assessment because of rising prostate-specific antigen level. Bone scan showed abnormal soft tissue uptake of Tc-MDP adjacent to the right scapula, compatible with a mass in MRI, thereafter. Because of the unavailability of Ga-PSMA scan in our department and also high cost in other centers, the patient underwent Lu-PSMA for more assessment, which revealed PSMA-avid mass. Pathologic examination confirmed the diagnosis of low-grade fibromatosis...
October 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29035540/targeted-clinical-nanoparticles-for-precision-cancer-therapy-based-on-disease-specific-molecular-inflection-points
#11
Charalambos Kaittanis, Alexander Bolaender, Barney Yoo, Nilesh Shah, Ouathek Ouerfelli, Jan Grimm
ional approaches based on clinical modular nanoplatforms are needed, in order to treat solid cancers according to their discrete molecular features. In the present study, we show that the clinical nanopharmaceutical Ferumoxytol, which consists of a glucose-based coat surrounding an iron oxide core, could identify molecular characteristics of prostate cancer, corresponding to unique phases of the disease continuum. By affixing a targeting probe for the prostate-specific membrane antigen on its surface, the nanopharmaceutical was able to assess the functional state of the androgen receptor pathway via MRI, guiding therapy and delivering it with the same clinical nanoparticle...
October 16, 2017: Nano Letters
https://www.readbyqxmd.com/read/29034282/differentiation-of-prostate-cancer-lesions-in-the-transition-zone-by-diffusion-weighted-mri
#12
Jie Bao, Ximing Wang, Chunhong Hu, Jianquan Hou, Fenglin Dong, Lingchuan Guo
OBJECTIVE: To differentiate prostate cancer lesions in transition zone by diffusion-weighted-MRI (DW-MRI). METHODS: Data from a total of 63 patients who underwent preoperative DWI (b of 0-1000 s/mm(2)) were prospectively collected and processed by a monoexponential (DWI) model and compared with a biexponential (IVIM) model for quantitation of apparent diffusion coefficients (ADCs), perfusion fraction f, diffusivity D and pseudo-diffusivity D*. Histogram analyses were performed by outlining entire-tumor regions of interest (ROIs)...
2017: European Journal of Radiology Open
https://www.readbyqxmd.com/read/29033565/double-receptor-targeting-multifunctional-iron-oxide-nanoparticles-drug-delivery-system-for-the-treatment-and-imaging-of-prostate-cancer
#13
Md Shakir Uddin Ahmed, Ahmad Bin Salam, Clayton Yates, Kyle Willian, Jesse Jaynes, Timothy Turner, Mohamed O Abdalla
As an alternative therapeutic treatment to reduce or eliminate the current side effects associated with advanced prostate cancer (PCa) chemotherapy, a multifunctional double-receptor-targeting iron oxide nanoparticles (IONPs) (luteinizing hormone-releasing hormone receptor [LHRH-R] peptide- and urokinase-type plasminogen activator receptor [uPAR] peptide-targeted iron oxide nanoparticles, LHRH-AE105-IONPs) drug delivery system was developed. Two tumor-targeting peptides guided this double-receptor-targeting nanoscale drug delivery system...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29032394/clinical-performance-of-68-ga-psma-11-pet-mri-for-the-detection-of-recurrent-prostate-cancer-following-radical-prostatectomy
#14
Benedikt Kranzbühler, Hannes Nagel, Anton S Becker, Julian Müller, Martin Huellner, Paul Stolzmann, Urs Muehlematter, Matthias Guckenberger, Philipp A Kaufmann, Daniel Eberli, Irene A Burger
PURPOSE: Sensitive visualization of recurrent prostate cancer foci is a challenge in patients with early biochemical recurrence (EBR). The recently established (68)Ga-PSMA-11 PET/CT has significantly improved the detection rate with published values of up to 55% for patients with a serum PSA concentration between 0.2-0.5 ng/mL. The increased soft tissue contrast in the pelvis using simultaneous (68)Ga-PSMA-11 PET/MRI might further improve the detection rate in patients with EBR and low PSA values over PET/CT...
October 14, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29031583/model-selection-for-high-b-value-diffusion-weighted-mri-of-the-prostate
#15
Yousef Mazaheri, Andreas M Hötker, Amita Shukla-Dave, Oguz Akin, Hedvig Hricak
PURPOSE: To assess the abilities of the standard mono-exponential (ME), bi-exponential (BE), diffusion kurtosis (DK) and stretched exponential (SE) models to characterize diffusion signal in malignant and prostatic tissues and determine which of the four models best characterizes these tissues on a per-voxel basis. MATERIALS AND METHODS: This institutional-review-board-approved, HIPAA-compliant, retrospective study included 55 patients (median age, 61years; range, 42-77years) with untreated, biopsy-proven PCa who underwent endorectal coil MRI at 3-Tesla, diffusion-weighted MRI acquired at eight b-values from 0 to 2000s/mm(2)...
October 11, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29029532/11c-choline-pet-ct-and-whole-body-mri-including-diffusion-weighted-imaging-for-patients-with-recurrent-prostate-cancer
#16
Hinrich Wieder, Ambros J Beer, Konstantin Holzapfel, Martin Henninger, Tobias Maurer, Sarah Schwarzenboeck, Ernst J Rummeny, Matthias Eiber, Jens Stollfuss
PURPOSE: To compare the detection efficacy of 11C-choline positron emission tomography and computed tomography (PET/CT) with whole-body magnetic resonance imaging (MRI) including diffusion-weighted imaging (DWI) in patients with suspected recurrent prostate cancer. MATERIALS AND METHODS: Fifty-seven patients (mean age 68, range 54-80 years) underwent 11C-choline PET/CT and MRI using T1-weighted (T1w), short-tau inversion recovery (STIR), and DWI. Two readers visually rated suspicious lesions on a 5-point scale in 20 different regions...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29028765/preventing-clinical-progression-and-need-for-treatment-in-patients-on-active-surveillance-for-prostate-cancer
#17
Hanan Goldberg, Zachary Klaassen, Thenappan Chandrasekar, Neil Fleshner
PURPOSE OF REVIEW: Active surveillance is an established treatment option for men with localized, low-risk prostate cancer (CaP). It entails the postponement of immediate therapy with the option of delayed intervention upon disease progression. The rate of clinical progression and need for treatment on active surveillance is approximately 50% over 15 years. The present review summarizes recent data on current methods, attempting to prevent clinical progression. RECENT FINDINGS: Patient selection for active surveillance is the first mandatory step required to lower progression...
October 11, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29025845/a-multicentre-randomised-controlled-trial-assessing-whether-mri-targeted-biopsy-is-non-inferior-to-standard-transrectal-ultrasound-guided-biopsy-for-the-diagnosis-of-clinically-significant-prostate-cancer-in-men-without-prior-biopsy-a-study-protocol
#18
Veeru Kasivisvanathan, Fatima Jichi, Laurence Klotz, Arnauld Villers, Samir S Taneja, Shonit Punwani, Alex Freeman, Mark Emberton, Caroline M Moore
INTRODUCTION: The classical pathway for the diagnosis of prostate cancer is transrectal ultrasound-guided (TRUS) biopsy of the prostate initiated on the basis of a raised prostate-specific antigen (PSA). An alternative pathway is to perform multi-parametricMRI (MPMRI) to localise cancer and to use this information to influence the decision for, and conduct of, a subsequent biopsy, known as an MPMRI-targeted biopsy. An MPMRI pathway has been shown to detect a similar or greater amount of clinically significant cancer as TRUS biopsy but has several advantages, including the potential to biopsy fewer men with fewer cores...
October 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29024425/multicentre-evaluation-of-magnetic-resonance-imaging-supported-transperineal-prostate-biopsy-in-biopsy-na%C3%A3-ve-men-with-suspicion-of-prostate-cancer
#19
N L Hansen, T Barrett, C Kesch, L Pepdjonovic, D Bonekamp, R O'Sullivan, F Distler, A Warren, C Samel, B Hadaschik, J Grummet, C Kastner
OBJECTIVES: To analyse the detection rates of primary MRI-fusion transperineal prostate biopsy using combined targeted and systematic core distribution in three tertiary referral centres. PATIENTS AND METHODS: Multicentre, prospective outcome study of 807 consecutive biopsy-naïve patients having undergone MRI-guided transperineal prostate biopsy as the first diagnostic intervention between 10/2012 and 05/2016. MRI was reported following PI-RADS criteria. 236 patients had 18-24 systematic transperineal biopsies only, and 571 patients underwent additional targeted biopsies either by MRI-fusion or cognitive targeting if PI-RADS ≥3 lesions were present...
October 11, 2017: BJU International
https://www.readbyqxmd.com/read/29023572/computer-aided-detection-in-prostate-cancer-diagnostics-a-promising-alternative-to-biopsy-a-retrospective-study-from-104-lesions-with-histological-ground-truth
#20
Anika Thon, Ulf Teichgräber, Cornelia Tennstedt-Schenk, Stathis Hadjidemetriou, Sven Winzler, Ansgar Malich, Ismini Papageorgiou
BACKGROUND: Prostate cancer (PCa) diagnosis by means of multiparametric magnetic resonance imaging (mpMRI) is a current challenge for the development of computer-aided detection (CAD) tools. An innovative CAD-software (Watson Elementary™) was proposed to achieve high sensitivity and specificity, as well as to allege a correlate to Gleason grade. AIM/OBJECTIVE: To assess the performance of Watson Elementary™ in automated PCa diagnosis in our hospital´s database of MRI-guided prostate biopsies...
2017: PloS One
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