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https://www.readbyqxmd.com/read/28443145/initial-single-centre-canadian-experience-with-18f-fluoromethylcholine-positron-emission-tomography-computed-tomography-18f-fch-pet-ct-for-biochemical-recurrence-in-prostate-cancer-patients-initially-treated-with-curative-intent
#1
Simon Gauvin, Yannick Cerantola, Eléonore Haberer, Vincent Pelsser, Stephan Probst, Franck Bladou, Maurice Anidjar
INTRODUCTION: We sought to determine predictive factors (patient and prostate-specific antigen [PSA] characteristics) for 18F-fluoromethylcholine positron emission tomography-computed tomography (18F-FCH PET/CT) positivity in the context of biochemical recurrence after local treatment of prostate cancer (PCa) with curative intent. METHODS: This is a retrospective study including 60 18F-FCH PET/CT scans of patients with biochemical recurrence after initial radical prostatectomy (RP), external beam radiation therapy (EBRT), or focal high-intensity focused ultrasound (HIFU) with curative intent...
January 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28440325/multiparametric-mri-ultrasound-fusion-guided-biopsy-decreases-detection-of-indolent-cancer-in-african-american-men
#2
M Kongnyuy, M M Siddiqui, A K George, A Muthigi, A Sidana, M Maruf, B Turkbey, P L Choyke, B J Wood, P A Pinto
BACKGROUND: Analysis of systematic 12-core biopsies (SBx) has shown that African-American (AA) men tend to harbor higher risk prostate cancer (PCa) at presentation relative to other races. Multiparametric magnetic resonance imaging (mpMRI) and MRI-ultrasound fusion-guided biopsy (FBx) have been shown to diagnose more intermediate- and high-risk PCa in the general population; however, the efficacy in AA remains largely uncharacterized. We aim to evaluate the utility of FBx in an AA patient cohort...
April 25, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28438871/multiparametric-mri-apparent-diffusion-coefficient-adc-accuracy-in-diagnosing-clinically-significant-prostate-cancer
#3
Pietro Pepe, Davide D'Urso, Antonio Garufi, Giandomenico Priolo, Michele Pennisi, Giorgio Russo, Maria Gabriella Sabini, Lucia Maria Valastro, Antonio Galia, Filippo Fraggetta
AIM: To evaluate the accuracy of multiparametric magnetic resonance imaging apparent diffusion coefficient (mpMRI ADC) in the diagnosis of clinically significant prostate cancer (PCa). PATIENTS AND METHODS: From January 2016 to December 2016, 44 patients who underwent radical prostatectomy for PCa and mpMRI lesions suggestive of cancer were retrospectively evaluated at definitive specimen. The accuracy of suspicious mpMRI prostate imaging reporting and data system (PI-RADS ≥3) vs...
May 2017: In Vivo
https://www.readbyqxmd.com/read/28438627/atypical-small-acinar-proliferation-and-high-grade-prostatic-intraepithelial-neoplasia-in-the-era-of-multi-parametric-mri-a-contemporary-review
#4
REVIEW
Todd G Manning, Ernest Cheung, Marlon Perera, Daniel Christidis, Jonathan S O'Brien, Catherine Mitchell, Damien M Bolton, Nathan Lawrentschuk
Multiparametric Magnetic Resonance Imaging (mpMRI) has added to the armamentarium for the diagnosis and surveillance for organ confined prostate cancer. Atypical small acinar proliferation (ASAP) and high-grade prostatic intraepithelial neoplasia (HGPIN) are premalignant prostatic lesions. The management of such lesions remains contentious, and the addition of mpMRI introduces further uncertainty given its ability to pick up indolent lesions and its use in targeted biopsy. We aimed to perform a comprehensive review of current evidence regarding ASAP, HGPIN and mpMRI to ascertain a consensus for a current management algorithm...
April 21, 2017: Urology
https://www.readbyqxmd.com/read/28437010/technical-note-comparison-of-peripheral-patient-dose-from-mr-guided-60-co-therapy-and-6mv-linear-accelerator-igrt
#5
Pascal Hauri, Roger A Hälg, Uwe Schneider
PURPOSE: The use of X-ray imaging in radiation therapy can give a substantial dose to the patient. A Cobalt machine combined with an magnetic resonance imaging (MRI) was recently introduced to clinical work. One positive aspect of using non-ionizing imaging devices is the reduction of the patient exposure. The purpose of this study was to quantify the difference in out-of-field dose to the patient between the image guided radiation therapy (IGRT) treatment applied with a linear accelerator with cone beam CT (CBCT) equipment and a Cobalt machine combined with an MRI...
April 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/28424829/-mri-of-the-prostate
#6
D Nörenberg, O Solyanik, B Schlenker, G Magistro, B Ertl-Wagner, D A Clevert, C Stief, M F Reiser, M D'Anastasi
New clinical and technological advances in the field of magnetic resonance imaging (MRI) and targeted image-guided biopsy techniques have significantly improved the detection, localization and staging as well as active surveillance of prostate cancer in recent years. Multiparametric MRI (mpMRI) is currently the main imaging technique for the detection, characterization and diagnostics of metastasizing prostate cancer and is of high diagnostic importance for local staging within the framework of the detection of prostate cancer...
April 19, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28422738/peripheral-zone-volume-ratio-pz-ratio-is-relevant-with-biopsy-results-and-can-increase-the-accuracy-of-current-diagnostic-modality
#7
Yifan Chang, Rui Chen, Qingsong Yang, Xu Gao, Chuanliang Xu, Jianping Lu, Yinghao Sun
The current diagnostic modality of prostate cancer based on prostate specific antigen (PSA) and systematic biopsy is far from ideal in terms of over-diagnosing indolent prostate cancer and missing significant ones. Thus we integrated the peripheral zone volume ratio (PZ-ratio) for diagnostic refinement. This retrospective study included 247 consecutive patients who underwent initial transrectal ultrasound-guided systematic prostate biopsy from April 2014 to November 2015. Prostate volume was determined by semi-automatic contour on axial T2 weighted magnetic resonance imaging (MRI)...
March 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418690/pi-rads-version-2-detection-of-clinically-significant-cancer-in-patients-with-biopsy-gleason-score-6-prostate-cancer
#8
Ji Won Seo, Su-Jin Shin, Young Taik Oh, Dae Chul Jung, Nam Hoon Cho, Young Deuk Choi, Sung Yoon Park
OBJECTIVE: The purpose of this study was to analyze the utility of the Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) in the detection of a clinically significant cancers in patients with prostate cancers with a biopsy Gleason score of 6. MATERIALS AND METHODS: A group of 182 consecutively registered patients with biopsy-proven prostate cancer with a Gleason score of 6 underwent MRI and radical prostatectomy. Clinically significant cancer was surgically defined as Gleason score of 7 or greater, tumor volume of 0...
April 18, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28415771/11c-choline-pet-ct-and-whole-body-mri-including-diffusion-weighted-imaging-for-patients-with-recurrent-prostate-cancer
#9
Hinrich Wieder, Ambros J Beer, Konstantin Holzapfel, Martin Henninger, Tobias Maurer, Sarah Schwarzenboeck, Ernst J Rummeny, Matthias Eiber, Jens Stollfuss
PURPOSE: To compare the detection efficacy of 11C-choline positron emission tomography and computed tomography (PET/CT) with whole-body magnetic resonance imaging (MRI) including diffusion-weighted imaging (DWI) in patients with suspected recurrent prostate cancer. MATERIAL AND METHODS: Fifty-seven patients (mean age 68, range 54-80 years) underwent 11C-choline PET/CT and MRI using T1-weighted (T1w), short-tau inversion recovery (STIR), and DWI. Two readers visually rated suspicious lesions on a 5-point scale in 20 different regions...
March 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413377/mimicry-of-appendicitis-symptomatology-in-congenital-anomalies-and-diseases-of-the-genitourinary-system-and-pregnancy
#10
REVIEW
Amanda Dalpiaz, Jason Gandhi, Noel L Smith, Gautam Dagur, Richard Schwamb, Steven J Weissbart, Sardar Ali Khan
INTRODUCTION: Appendicitis is a prevailing cause of acute abdomen, but is often difficult to diagnose due to its wide range of symptoms, anatomical variations, and developmental abnormalities. Urological disorders of the genitourinary tract may be closely related to appendicitis due to the close proximity of the appendix to the genitourinary tract. This review provides a summary of the urological complications and simulations of appendicitis. Both typical and urological symptoms of appendicitis are discussed, as well as recommended diagnostic and treatment methods...
January 2017: Current Urology
https://www.readbyqxmd.com/read/28412063/diagnostic-performance-of-magnetic-resonance-imaging-for-the-detection-of-bone-metastasis-in-prostate-cancer-a-systematic-review-and-meta-analysis
#11
Sungmin Woo, Chong Hyun Suh, Sang Youn Kim, Jeong Yeon Cho, Seung Hyup Kim
CONTEXT: Magnetic resonance imaging (MRI) has been tested for detecting bone metastasis and has shown promising results. Yet, consensus has not been reached regarding whether it can replace the role of bone scintigraphy in this clinical setting or not. OBJECTIVE: To review the diagnostic performance of contemporary (≥1.5 T) MRI for the detection of bone metastasis in patients with prostate cancer. EVIDENCE ACQUISITION: MEDLINE and EMBASE were searched up to January 22, 2017...
April 12, 2017: European Urology
https://www.readbyqxmd.com/read/28409355/percutaneous-mr-guided-focal-cryoablation-for-recurrent-prostate-cancer-following-radiation-therapy-retrospective-analysis-of-iceball-margins-and-outcomes
#12
Christiaan G Overduin, Sjoerd F M Jenniskens, J P Michiel Sedelaar, Joyce G R Bomers, Jurgen J Fütterer
OBJECTIVES: To evaluate iceball margins after magnetic resonance (MR)-guided focal salvage prostate cryoablation and determine the correlation with local outcome. METHODS: A retrospective review was performed on 47 patients that underwent percutaneous MR-guided focal cryoablation for biopsy-proven locally recurrent prostate cancer after primary radiotherapy. Preprocedural diagnostic and intraprocedural MR images were analysed to derive three-directional iceball margins...
April 13, 2017: European Radiology
https://www.readbyqxmd.com/read/28409073/facial-paralysis-and-hearing-loss-a-rare-manifestation-of-prostate-cancer-metastases
#13
Uroosa Ibrahim, Amina Saqib, Farhan Mohammad, Muhammad R Raza, Nikhil Nalluri, Frank Forte
Dural prostate metastases (DPM) are a rare manifestation of metastatic prostate cancer seen in approximately one to six percent of cases. Presenting symptoms may include signs of elevated intracranial pressure, headache, altered mental status, or cranial nerve palsies. Hearing loss, sensory changes, dysarthria, and dysphagia are rare symptoms in DPM that were present in our patient. We present a case of a 58-year-old male with a known diagnosis of adenocarcinoma of the prostate presenting with symptoms of acute exacerbation of chronic obstructive pulmonary disease (COPD), sub-acute right-sided hearing loss, and right-sided facial paralysis...
March 3, 2017: Curēus
https://www.readbyqxmd.com/read/28401579/mri-assessment-of-tissue-effects-after-180-w-xps-greenlight-laser-vaporization-of-the-prostate
#14
Romain Huet, Romain Mathieu, Tanguy Rohou, Benoit Peyronnet, Andrea Manunta, Gregory Verhoest, Karim Bensalah, Sebastien Vincendeau
BACKGROUND AND OBJECTIVE: Photoselective vaporization of the prostate (PVP) is an alternative to transurethral resection of the prostate (TURP) in the surgical management of Benign Prostate Obtruction (BPO), with a better hemostatic effect due to a coagulation depth of several millimeters. The objective of this study was to prospectively assess the tissue effects of PVP by Magnetic Resonance Imaging (MRI). MATERIALS AND METHODS: From December to February 2014, ten patients were included in a prospective study and underwent PVP performed by a single surgeon with the Greenlight™ laser 180-W XPS...
April 11, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28401244/integrated-68-ga-hbed-cc-psma-pet-mri-in-patients-with-suspected-recurrent-prostate-cancer
#15
Susanne Lütje, Joseph Cohnen, Benedikt Gomez, Johannes Grüneisen, Lino Sawicki, Herbert Rübben, Andreas Bockisch, Lale Umutlu, Thorsten D Pöppel, Axel Wetter
AIM: Evaluate the diagnostic accuracy of (68)Ga-labeled HBED-CC-PSMA-PET/MRI for detection of recurrent PCa in comparison to PET/CT. METHODS: 48 patients with suspected recurrent PCa underwent PET/CT after injection of the (68)Ga-HBED-CC-PSMA ligand followed by integrated PET/MRI. Image analysis was performed by nuclear medicine physicians and radiologists with respect to the detection of lymph node metastases, bone metastases and local recurrence of the tumour...
April 12, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/28400169/combined-clinical-parameters-and-multiparametric-magnetic-resonance-imaging-for-advanced-risk-modeling-of-prostate-cancer-patient-tailored-risk-stratification-can-reduce-unnecessary-biopsies
#16
Jan Philipp Radtke, Manuel Wiesenfarth, Claudia Kesch, Martin T Freitag, Celine D Alt, Kamil Celik, Florian Distler, Wilfried Roth, Kathrin Wieczorek, Christian Stock, Stefan Duensing, Matthias C Roethke, Dogu Teber, Heinz-Peter Schlemmer, Markus Hohenfellner, David Bonekamp, Boris A Hadaschik
BACKGROUND: Multiparametric magnetic resonance imaging (mpMRI) is gaining widespread acceptance in prostate cancer (PC) diagnosis and improves significant PC (sPC; Gleason score≥3+4) detection. Decision making based on European Randomised Study of Screening for PC (ERSPC) risk-calculator (RC) parameters may overcome prostate-specific antigen (PSA) limitations. OBJECTIVE: We added pre-biopsy mpMRI to ERSPC-RC parameters and developed risk models (RMs) to predict individual sPC risk for biopsy-naïve men and men after previous biopsy...
April 8, 2017: European Urology
https://www.readbyqxmd.com/read/28397150/quantitative-effects-of-acquisition-duration-and-temporal-resolution-on-the-measurement-accuracy-of-prostate-dynamic-contrast-enhanced-mri-data-a-phantom-study
#17
Silvin Paul Knight, Jacinta Elizabeth Browne, James Frances Mary Meaney, Andrew John Fagan
OBJECTIVES: The aim of this study was to investigate the effect of the temporal resolution (T res) and acquisition duration (AD) on the measurement accuracy of contrast concentration-time curves (CTCs), and derived phenomenological and pharmacokinetic parameter values, in a dynamic contrast-enhanced MRI experiment using a novel phantom test device. MATERIALS AND METHODS: 'Ground truth' CTCs were established using a highly precise optical imaging system. These precisely known CTCs were produced in an anthropomorphic environment, which mimicked the male pelvic region, and presented to the MRI scanner for measurement...
April 10, 2017: Magma
https://www.readbyqxmd.com/read/28396920/the-role-of-whole-lesion-apparent-diffusion-coefficient-analysis-for-predicting-outcomes-of-prostate-cancer-patients-on-active-surveillance
#18
Tsutomu Tamada, Hasan Dani, Samir S Taneja, Andrew B Rosenkrantz
PURPOSE: To explore the role of whole-lesion apparent diffusion coefficient (ADC) analysis for predicting outcomes in prostate cancer patients on active surveillance. METHODS: This study included 72 prostate cancer patients who underwent MRI-ultrasound fusion-targeted biopsy at the initiation of active surveillance, had a visible MRI lesion in the region of tumor on biopsy, and underwent 3T baseline and follow-up MRI examinations separated by at least one year. Thirty of the patients also underwent an additional MRI-ultrasound fusion-targeted biopsy after the follow-up MRI...
April 10, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28396184/focal-laser-ablation-of-prostate-cancer-feasibility-of-mri-us-fusion-for-guidance
#19
Shyam Natarajan, Tonye A Jones, Alan M Priester, Rory Geoghegan, Patricia Lieu, Merdie Delfin, Ely Felker, Daniel J A Margolis, Anthony Sisk, Allan Pantuck, Warren Grundfest, Leonard S Marks
PURPOSE: Focal laser ablation (FLA) is a potential treatment for some men with prostate cancer (CaP). As currently practiced, FLA is performed by radiologists in a MRI unit (in-bore). We evaluated the safety and feasibility of performing FLA in a urology clinic (out-of-bore), using magnetic resonance imaging-ultrasound (MRI/US) fusion for guidance. MATERIALS AND METHODS: 11 men with intermediate risk CaP were enrolled in this prospective, IRB-approved pilot study...
April 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28396178/magnetic-resonance-imaging-basics-for-the-prostate-brachytherapist
#20
REVIEW
Jihong Wang, Kari Tanderup, Adam Cunha, Antonio L Damato, Gil'ad N Cohen, Rajat J Kudchadker, Firas Mourtada
Magnetic resonance imaging (MRI) is increasingly being used in radiation therapy, and integration of MRI into brachytherapy in particular is becoming more common. We present here a systematic review of the basic physics and technical aspects of incorporating MRI into prostate brachytherapy. Terminology and MRI system components are reviewed along with typical work flows in prostate high-dose-rate and low-dose-rate brachytherapy. In general, the brachytherapy workflow consists of five key components: diagnosis, implantation, treatment planning (scan + plan), implant verification, and delivery...
April 7, 2017: Brachytherapy
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