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https://www.readbyqxmd.com/read/29243110/retrospective-analysis-of-the-development-of-pirads-3-lesions-over-time-when-is-a-follow-up-mri-reasonable
#1
Fabian Steinkohl, Leonhard Gruber, Jasmin Bektic, Udo Nagele, Friedrich Aigner, Thomas R W Herrmann, Michael Rieger, Daniel Junker
PURPOSE: Often PIRADS 3 findings are usually followed up with further MRIs of the prostate. Current guidelines do not state an optimal interval between the initial MRI and the follow-up MRI. The aim of this study was to find out if PIRADS 3 lesions evolve over time and to determine how long the optimal interval between initial MRI and follow-ups should be. METHODS: In this retrospective study, 141 consecutive patients were included who underwent at least one follow-up MRI after an initial PIRADS 3 finding...
December 14, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29242748/optimization-of-prostate-mri-acquisition-and-post-processing-protocol-a-pictorial-review-with-access-to-acquisition-protocols
#2
REVIEW
Ivan Jambor
The aim of this review article is to provide insight into the optimization of 1.5-Testla (T) and 3-T prostate magnetic resonance imaging (MRI). An approach for optimization of data quantification, especially diffusion-weighted imaging (DWI), is provided. Benefits and limitations of various pulse sequences are discussed. Importable MRI protocols and access to imaging datasets is provided. Careful optimization of prostate MR acquisition protocol allows the acquisition of high-quality prostate MRI using clinical 1...
December 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/29241706/placement-of-an-absorbable-rectal-hydrogel-spacer-in-patients-undergoing-low-dose-rate-brachytherapy-with-palladium-103
#3
Amandeep S Taggar, Tomer Charas, Gil'ad N Cohen, Keeratikarn Boonyawan, Marisa Kollmeier, Sean McBride, Nitin Mathur, Antonio L Damato, Michael J Zelefsky
PURPOSE: Rates of rectal toxicity after low-dose-rate (LDR) brachytherapy for prostate cancer are dependent on rectal dose, which is associated with rectal distance from prostate and implanted seeds. Placement of a hydrogel spacer between the prostate and rectum has proven to reduce the volume of the rectum exposed to higher radiation dose levels in the setting of external beam radiotherapy. We present our findings with placing a rectal hydrogel spacer in patients following LDR brachytherapy, and we further assess the impact of this placement on dosimetry and acute rectal toxicity...
December 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29239082/utility-of-early-transperineal-template-guided-prostate-biopsy-for-risk-stratification-in-men-undergoing-active-surveillance-for-prostate-cancer
#4
James Voss, Raj Pal, Shaista Ahmed, Magnus Hannah, Adil Jaulim, Thomas Walton
OBJECTIVE: To assess the accuracy and utility of routine multiparametric MRI (mp-MRI) and transperineal template-guided prostate biopsy (TPB) following enrolment on to active surveillance. PATIENTS AND METHODS: From April 2012 to December 2016 consecutive men from our single institution diagnosed with low or intermediate risk prostate cancer on TRUS biopsy were offered further staging with early mp-MRI and TPB within 12 months of diagnosis. Data was collected prospectively...
December 14, 2017: BJU International
https://www.readbyqxmd.com/read/29238867/a-direct-comparison-of-contrast-enhanced-ultrasound-and-dynamic-contrast-enhanced-magnetic-resonance-imaging-for-prostate-cancer-detection-and-prediction-of-aggressiveness
#5
Alexander D J Baur, Julia Schwabe, Julian Rogasch, Andreas Maxeiner, Tobias Penzkofer, Carsten Stephan, Marc Rudl, Bernd Hamm, Ernst-Michael Jung, Thom Fischer
INTRODUCTION: Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and contrast-enhanced ultrasound (CEUS) analyse tissue vascularization. We evaluated if CEUS can provide comparable information as DCE-MRI for the detection of prostate cancer (PCa) and prediction of its aggressiveness. MATERIAL AND METHODS: A post-hoc evaluation of 92 patients was performed. In each patient CEUS and DCE-MRI parameters of the most suspicious lesion identified on MRI were analysed...
December 13, 2017: European Radiology
https://www.readbyqxmd.com/read/29234263/atypical-small-acinar-proliferation-and-high-grade-prostatic-intraepithelial-neoplasia-should-we-be-concerned-an-observational-cohort-study-with-a-minimum-follow-up-of-3-years
#6
Vinaya Srirangam, Bhavan Prasad Rai, Ahmed Abroaf, Samita Agarwal, Sergey Tadtayev, Charlotte Foley, Tim Lane, Jim Adshead, Nikhil Vasdev
Introduction: Atypical small acinar proliferation (ASAP) and high grade prostatic intraepithelial neoplasia (HGPIN) are considered precancerous. We aimed to measure the rate of repeat biopsy and adenocarcinoma in patients with ASAP and HGPIN and identify any clinico-pathologic parameters at diagnosis of ASAP/HGPIN that are predictive of adenocarcinoma. Materials and Methods: Patients with a diagnosis of ASAP/HGPIN with no previous or concomitant cancer were identified...
November 2017: Current Urology
https://www.readbyqxmd.com/read/29233150/a-prospective-study-of-magnetic-resonance-imaging-and-ultrasonography-mri-us-fusion-targeted-biopsy-and-concurrent-systematic-transperineal-biopsy-with-the-average-of-18-cores-to-detect-clinically-significant-prostate-cancer
#7
Yuji Hakozaki, Hisashi Matsushima, Jimpei Kumagai, Taro Murata, Tomoko Masuda, Yoko Hirai, Mai Oda, Nobuo Kawauchi, Munehiro Yokoyama, Yukio Homma
BACKGROUND: This study compared the detection rates for clinically significant prostate cancer (CSPC) between magnetic resonance imaging and ultrasonography (MRI/US)-fusion-targeted biopsy (TB), systematic biopsy (SB) and combination of TB and SB. METHODS: This prospective study evaluated simultaneous TB and SB for consecutive patients with suspicious lesions that were detected using pre-biopsy multiparametric MRI. A commercially available real-time virtual sonography system was used to perform the MRI/US-fusion TB with the transperineal technique...
December 12, 2017: BMC Urology
https://www.readbyqxmd.com/read/29232269/mr-guided-biopsy-and-focal-therapy-new-options-for-prostate-cancer-management
#8
Fuad F Elkhoury, Demetrios N Simopoulos, Leonard S Marks
PURPOSE OF REVIEW: Options for prostate cancer management are rapidly expanding. The recent advent of MRI technology has led to guided prostate biopsies by radiologists working in-bore or by urologists using MR/US fusion technology. The resulting tumor visualization now provides the option of focal therapy. Currently available are highly directed energies - focused ultrasound (HIFU), cryotherapy, and laser - all offering the hope of curing prostate cancer with few side effects. RECENT FINDINGS: MRI now enables visualization of many prostate cancers...
December 11, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29232037/incorporating-prostate-health-index-density-mri-and-prior-negative-biopsy-status-to-improve-the-detection-of-clinically-significant-prostate-cancer
#9
Sasha C Druskin, Jeffrey J Tosoian, Allen Young, Sarah Collica, Arnav Srivastava, Kamyar Ghabili, Katarzyna J Macura, Ballentine H Carter, Alan W Partin, Lori J Sokoll, Ashley E Ross, Christian P Pavlovich
OBJECTIVES: To determine the performance of Prostate Health Index (PHI) density (PHID) combined with MRI and prior negative biopsy (PNB) status for the diagnosis of clinically-significant prostate cancer (PCa). PATIENTS & METHODS: Patients without a prior diagnosis of PCa, with elevated PSA and a normal digital rectal exam who had PHI testing prospectively prior to prostate biopsy were included. PHID was calculated retrospectively using prostate volume derived from transrectal ultrasound at biopsy...
December 12, 2017: BJU International
https://www.readbyqxmd.com/read/29230498/trans-rectal-ultrasound-guided-autologous-blood-injection-in-the-interprostatorectal-space-prior-to-percutaneous-mri-guided-cryoablation-of-the-prostate
#10
Julien Garnon, Roberto Luigi Cazzato, Guillaume Koch, Ishaq Fahmi Uri, Georgia Tsoumakidou, Jean Caudrelier, Thibault Tricard, Afshin Gangi, Hervé Lang
OBJECTIVE: To report a novel technique of ultrasound-guided injection of autologous blood in the interprostatorectal space, in an attempt to facilitate ablative prostatic procedures by widening durably the space between the rectum and the prostate. MATERIALS AND METHODS: Between April and November 2016, four consecutive patients underwent the haemoprotection injection technique. For each patient, we recorded the time to perform the technique, the amount of injected blood, the achieved distances between the rectum and the prostate post-injection at fixed defined points (apex, middle, and base of prostate at the midline, left, and right sides of the gland), the extension of the ice ball outside the prostate capsule at those fixed points, and whether any residual blood was present on 1-month follow-up MRI...
December 11, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29226826/prostate-magnetic-resonance-imaging-interpretation-varies-substantially-across-radiologists
#11
Geoffrey A Sonn, Richard E Fan, Pejman Ghanouni, Nancy N Wang, James D Brooks, Andreas M Loening, Bruce L Daniel, Katherine J To'o, Alan E Thong, John T Leppert
BACKGROUND: Multiparametric magnetic resonance imaging (mpMRI) interpreted by experts is a powerful tool for diagnosing prostate cancer. However, the generalizability of published results across radiologists of varying expertise has not been verified. OBJECTIVE: To assess variability in mpMRI reporting and diagnostic accuracy across radiologists of varying experience in routine clinical care. DESIGN, SETTING, AND PARTICIPANTS: Men who underwent mpMRI and MR-fusion biopsy between 2014-2016...
December 6, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29226040/creutzfeldt-cell-rich-glioblastoma-a-diagnostic-dilemma
#12
Zain Boghani, William J Steele, Matthew D Cykowski, Leomar Y Ballester, Gavin Britz
Differentiating demyelinating conditions from neoplastic conditions can pose a significant challenge. There are a number of reports in the literature of large ring-enhancing, space-occupying lesions that were initially considered neoplastic or infectious but, on further review, were deemed demyelinating. Creutzfeldt-Peters cells (CPC) are reactive astrocytes with fragmented nuclear inclusions that are routinely seen in multiple sclerosis (MS) and generally exclude the diagnosis of glioblastoma (GB). The patient is a 78-year-old man with a history of prostate cancer, which was treated with radiation therapy, who presented with altered mental status...
October 5, 2017: Curēus
https://www.readbyqxmd.com/read/29222677/diagnostic-evaluation-of-magnetization-transfer-and-diffusion-kurtosis-imaging-for-prostate-cancer-detection-in-a-re-biopsy-population
#13
Tristan Barrett, Mary McLean, Andrew N Priest, Edward M Lawrence, Andrew J Patterson, Brendan C Koo, Ilse Patterson, Anne Y Warren, Andrew Doble, Vincent J Gnanapragasam, Christof Kastner, Ferdia A Gallagher
OBJECTIVE: To evaluate diffusion kurtosis imaging (DKI) and magnetisation transfer imaging (MTI) compared to standard MRI for prostate cancer assessment in a re-biopsy population. METHODS: Thirty-patients were imaged at 3 T including DKI (Kapp and Dapp) with b-values 150/450/800/1150/1500 s/mm2 and MTI performed with and without MT saturation. Patients underwent transperineal biopsy based on prospectively defined MRI targets. Receiver-operating characteristic (ROC) analyses assessed the parameters and Wilcoxon-signed ranked test assessed relationships between metrics...
December 8, 2017: European Radiology
https://www.readbyqxmd.com/read/29221153/-68ga-pentixafor-for-cxcr4-imaging-in-a-pc-3-prostate-cancer-xenograft-model-comparison-with-18f-fdg-pet-ct-mri-and-ex-vivo-receptor-expression
#14
Sarah M Schwarzenböck, Jan Stenzel, Thomas Otto, Heike V Helldorff, Carina Bergner, Jens Kurth, Stefan Polei, Tobias Lindner, Romina Rauer, Alexander Hohn, Oliver W Hakenberg, Hans J Wester, Brigitte Vollmar, Bernd J Krause
Purpose: The aim was to characterize the properties of [68Ga]Pentixafor as tracer for prostate cancer imaging in a PC-3 prostate cancer xenograft mouse model and to investigate its correlation with [18F]FDG PET/CT, magnetic resonance imaging (MRI) and ex vivo analyses. Methods: Static [68Ga]Pentixafor and [18F]FDG PET as well as morphological/ diffusion weighted MRI and 1H MR spectroscopy was performed. Imaging data were correlated with ex vivo biodistribution and CXCR4 expression in PC-3 tumors (immunohistochemistry (IHC), mRNA analysis)...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220213/clinical-application-of-biparametric-mri-texture-analysis-for-detection-and-evaluation-of-high-grade-prostate-cancer-in-zone-specific-regions
#15
Xiang-Ke Niu, Zhi-Fan Chen, Lin Chen, Jun Li, Tao Peng, Xin Li
OBJECTIVE: The purpose of this study was to investigate the performance of biparametric MRI texture analysis (TA) in detecting and evaluating high-grade prostate cancer in zone-specific regions. MATERIALS AND METHODS: A retrospective study included 184 consecutively registered biopsy-naive patients in whom prostate cancer was suspected who were undergoing multiparametric prostate MRI. MR images were scored and evaluated by two readers using the Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) and biparametric MRI TA in separate sessions...
December 8, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29217354/prostate-magnetic-resonance-imaging-provides-limited-incremental-value-over-the-memorial-sloan-kettering-cancer-center-pre-radical-prostatectomy-nomogram
#16
John K Weaver, Eric H Kim, Joel M Vetter, Anup Shetty, Robert L Grubb, Seth A Strope, Gerald L Andriole
OBJECTIVES: To examine the incremental value of prostate MRI when used in combination with the currently available preoperative risk stratification tool the Memorial Sloan Kettering Cancer Center Pre-Radical Prostatectomy Nomogram (MSKCC). METHODS: We reviewed our institutional database of prostate MRI performed prior to radical prostatectomy between December 2014 and March 2016 (n=236). We generated a logistic regression model based on observed final pathology results and the MSKCC nomogram predictions for organ confined disease, extracapsular extension (ECE), seminal vesicle invasion (SVI), and lymph node (LN) involvement ('MSKCC Only')...
December 4, 2017: Urology
https://www.readbyqxmd.com/read/29212868/painful-testicular-metastasis-from-prostate-adenocarcinoma
#17
Karla A Lee, Erik Mayer, Vincent Khoo
A 60-year-old man presented with unilateral testicular pain and urinary frequency. His presenting prostate-specific antigen (PSA) was 100 ng/mL, and a biopsy revealed Gleason 4+4 prostate adenocarcinoma. The significance of his initial PSA was somewhat complicated by possible prostatitis and early initiation of bicalutamide. PSA rose on two occasions prior to radiotherapy but coincided with a flare of testicular pain on one of these. Whole-body staging diffusion-weighted MRI scan was negative. He was treated with 3 years of androgen deprivation therapy (ADT) and radical radiotherapy...
December 5, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29212392/multi-parametric-magnetic-resonance-imaging-monitoring-patients-in-active-surveillance-for-prostate-cancer-a-prospective-cohort-study
#18
Maria Carlsen Elkjær, Morten Heebøll Andersen, Søren Høyer, Bodil Ginnerup Pedersen, Michael Borre
OBJECTIVES: To evaluate the use of multi-parametric magnetic resonance imaging (mpMRI) and mpMRI guided biopsies (MRGB) for monitoring an active surveillance (AS) prostate cancer cohort. MATERIALS AND METHODS: One year after initial diagnostic TRUS guided biopsy (TRUS-bx), baseline mpMRI, and enrolment in an AS program patients underwent a one year follow-up comprising the usual TRUS-bx and an mpMRI. Prostate MRI lesions were scored on the five-point PIRADS scale version 2...
December 7, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/29212368/impact-of-variations-in-prostatic-apex-shape-on-apical-margin-positive-rate-after-radical-prostatectomy-robot-assisted-laparoscopic-radical-prostatectomy-versus-open-radical-prostatectomy
#19
Young Dong Yu, Minseung Lee, Sung Kyu Hong, Seok-Soo Byun, Sang Eun Lee, Sangchul Lee
AIM: To evaluate the effects of prostatic apex shape variations on positive apical margin rate (PAM) after radical prostatectomy (RP) by undertaking a comparative study of robot-assisted laparoscopic radical prostatectomy (RALP) versus open radical prostatectomy (ORP). METHODS: A total 3,324 cases of RP (1,004 ORP and, 2,320 RALP) from January 2004 to March 2017 were retrospectively reviewed. All patients underwent preoperative magnetic resonance imaging (MRI) and the cohorts were stratified into 4 categories according to prostatic apical shape at the mid-sagittal plane...
December 6, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29211932/targeted-versus-systematic-robot-assisted-transperineal-mri-trus-fusion-prostate-biopsy
#20
J Mischinger, S Kaufmann, G I Russo, N Harland, S Rausch, B Amend, M Scharpf, L Loewe, T Todenhoefer, M Notohamiprodjo, K Nikolaou, A Stenzl, J Bedke, S Kruck
OBJECTIVES: To evaluate the performance of transperineal robot-assisted (RA) targeted (TB) and systematic (SB) prostate biopsy in the primary and repeat biopsy setting. PATIENTS AND METHODS: Patients were admitted to RA biopsy between 2014-2016. Prior to RA-TB, multiparametric (mp) Magnetic Resonance Imaging (MRI) was performed. Prostate lesions were scored (Prostate Imaging, Reporting and Data System Version 2) and used for RA-TB planning. In addition, RA-SB was performed...
December 6, 2017: BJU International
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