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Assessment psychosis

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https://www.readbyqxmd.com/read/28717382/neurological-soft-signs-in-tunisian-patients-with-first-episode-psychosis-and-relation-with-cannabis-use
#1
Ahmed Mhalla, Bochra Ben Mohamed, Christoph U Correll, Badii Amamou, Anouar Mechri, Lotfi Gaha
BACKGROUND: Neurological soft signs (NSS) are minor non-localizing neurological abnormalities that are conceptualized as neurodevelopmental markers that mediate the biological risk for psychosis. We aimed to explore the relationship between NSS and cannabis use, an environmental risk factor of psychosis. METHODS: This was a cross-sectional study in consecutively admitted patients hospitalized for first-episode psychosis. NSS were assessed by the NSS scale (23 items exploring motor coordination, motor integrative function, sensory integration, involuntary movements or posture, quality of lateralization)...
2017: Annals of General Psychiatry
https://www.readbyqxmd.com/read/28713586/formal-thought-disorder-in-people-at-ultra-high-risk-of-psychosis
#2
Arsime Demjaha, Sara Weinstein, Daniel Stahl, Fern Day, Lucia Valmaggia, Grazia Rutigliano, Andrea De Micheli, Paolo Fusar-Poli, Philip McGuire
BACKGROUND: Formal thought disorder is a cardinal feature of psychosis. However, the extent to which formal thought disorder is evident in ultra-high-risk individuals and whether it is linked to the progression to psychosis remains unclear. AIMS: Examine the severity of formal thought disorder in ultra-high-risk participants and its association with future psychosis. METHOD: The Thought and Language Index (TLI) was used to assess 24 ultra-high-risk participants, 16 people with first-episode psychosis and 13 healthy controls...
July 2017: BJPsych Open
https://www.readbyqxmd.com/read/28712969/the-role-of-self-disturbances-and-cognitive-biases-in-the-relationship-between-traumatic-life-events-and-psychosis-proneness-in-a-non-clinical-sample
#3
Łukasz Gawęda, Katarzyna Prochwicz, Przemysław Adamczyk, Dorota Frydecka, Błażej Misiak, Kamila Kotowicz, Remigiusz Szczepanowski, Marcin Florkowski, Barnaby Nelson
BACKGROUND: Traumatic life events have been established as an environmental risk factor for psychosis. However, the exact mechanisms by which traumatic life events increase risk for psychosis are unknown. In the present study we tested an integrative model of traumatic life events being related to psychosis proneness via self-disturbances and cognitive biases. METHODS: The sample consisted of 653 healthy people. Traumatic life events, self-disturbances, cognitive biases and psychosis proneness were assessed with self-report questionnaires...
July 13, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28712967/clinical-utility-of-the-calgary-depression-scale-for-schizophrenia-in-individuals-at-ultra-high-risk-of-psychosis
#4
Gurpreet Rekhi, Wai Yee Ng, Jimmy Lee
There is a pressing need for reliable and valid rating scales to assess and measure depression in individuals at ultra-high risk (UHR) of psychosis. The aim of this study was to examine the clinical utility of the Calgary Depression Scale for Schizophrenia (CDSS) in individuals at UHR of psychosis. 167 individuals at UHR of psychosis were included as participants in this study. The Structured Clinical Interview for DSM-IV Axis I Disorders, CDSS, Beck Anxiety Inventory and Global Assessment of Functioning were administered...
July 13, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28711798/psychotic-like-experiences-and-happiness-in-the-english-general-population
#5
Ai Koyanagi
BACKGROUND: Psychotic-like experiences (PLEs) have been associated with a variety of adverse outcomes but how they affect happiness in individuals with PLE is unknown. Thus, the aim of the study was to assess the association between PLEs and happiness, and the factors that may influence this association. METHODS: Nationally representative data from the 2007 Adult Psychiatric Morbidity Survey including adults aged ≥ 16 years was analyzed. The Psychosis Screening Questionnaire was used to assess past 12-month PLE...
July 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28711662/the-clinical-and-prognostic-value-of-motor-abnormalities-in-psychosis-and-the-importance-of-instrumental-assessment
#6
REVIEW
Peter N van Harten, Sebastian Walther, Jerillyn S Kent, Scott R Sponheim, Vijay A Mittal
Motor abnormalities comprise several clinical signs intrinsic to psychosis. Critically, these features are of prognostic value in individuals at-risk for psychosis, and for those in early stages of psychotic disorders. Motor abnormalities such as tremor, rigidity, and neurological soft signs often go unrecognized. Currently, advances in this area are limited by a paucity of theoretical conceptions categorizing or linking these behaviors to underlying neurobiology affected in psychosis. However, emerging technological advances have significantly improved the ability to detect and assess motor abnormalities with objective instruments in a timely and reliable manner...
July 12, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28711473/interaction-of-reelin-and-stress-on-immobility-in-the-forced-swim-test-but-not-dopamine-mediated-locomotor-hyperactivity-or-prepulse-inhibition-disruption-relevance-to-psychotic-and-mood-disorders
#7
Michael J Notaras, Billie Vivian, Carey Wilson, Maarten van den Buuse
RATIONALE: Psychotic disorders, such as schizophrenia, as well as some mood disorders, such as bipolar disorder, have been suggested to share common biological risk factors. One such factor is reelin, a large extracellular matrix glycoprotein that regulates neuronal migration during development as well as numerous activity-dependent processes in the adult brain. The current study sought to evaluate whether a history of stress exposure interacts with endogenous reelin levels to modify behavioural endophenotypes of relevance to psychotic and mood disorders...
July 13, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28707502/appraisal-of-the-psychiatric-diagnostic-screening-questionnaire-in-a-perinatal-cohort-the-apron-study
#8
Brenda Leung, Nicole Letourneau, Katherine Bright, Gerald F Giesbrecht, Henry Ntanda, Lisa Gagnon
BACKGROUND: Depression and anxiety are routinely screened as part of perinatal care. However, other Axis 1 disorders and specific anxiety disorders are less likely to be screened or assessed as part of obstetric care. The objective of this study was to determine whether the Psychiatric Diagnostic Screening Questionnaire (PDSQ) is a potentially useful tool to screen for psychiatric conditions in pregnant and postpartum women in a community setting. METHODS: We compared the prevalence of DSM Axis I disorders obtained on the PDSQ with: (1) the prevalence of these disorders reported in previous studies of pregnant and postpartum women, and (2) scores obtained on the Edinburgh Postpartum Depression Scale (EPDS) and the Symptom Checklist-90-Revised (SCL-90R) anxiety scale...
July 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28707138/gray-matter-changes-and-cognitive-predictors-of-2-year-follow-up-abnormalities-in-early-onset-first-episode-psychosis
#9
Josefina Castro-Fornieles, Nuria Bargalló, Anna Calvo, Celso Arango, Immaculada Baeza, Ana Gonzalez-Pinto, Mara Parellada, Montserrat Graell, Carmen Moreno, Soraya Otero, Joost Janssen, Marta Rapado-Castro, Elena de la Serna
This study aims to examine regional gray matter (GM) changes over a period of 2 years in patients diagnosed with early-onset first-episode psychosis (EO-FEP), and to identify baseline predictors of abnormalities at the follow-up. Fifty-nine patients with EO-FEP aged 11-17 years were assessed. Magnetic resonance imaging was carried out at admission and 2 years later. Changes over time were assessed with voxel-based morphometry. Fifty-nine patients (34 schizophrenia-SCZ, 15 bipolar disorder-BP, and 10 other psychotic disorders) and 70 healthy controls were assessed...
July 13, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28705600/poor-medication-adherence-and-risk-of-relapse-associated-with-continued-cannabis-use-in-patients-with-first-episode-psychosis-a-prospective-analysis
#10
Tabea Schoeler, Natalia Petros, Marta Di Forti, Ewa Klamerus, Enrico Foglia, Robin Murray, Sagnik Bhattacharyya
BACKGROUND: Cannabis use following the onset of first-episode psychosis has been linked to both increased risk of relapse and non-adherence with antipsychotic medication. Whether poor outcome associated with cannabis use is mediated through an adverse effect of cannabis on medication adherence is unclear. METHODS: In a prospective analysis of data acquired from four different adult inpatient and outpatient units of the South London and Maudsley Mental Health National Health Service Foundation Trust in London, UK, 245 patients were followed up for 2 years from the onset of first-episode psychosis...
July 10, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28701292/short-text-messages-to-encourage-adherence-to-medication-and-follow-up-for-people-with-psychosis-mobile-net-randomized-controlled-trial-in-finland
#11
Maritta Välimäki, Kati Anneli Kannisto, Tero Vahlberg, Heli Hätönen, Clive E Adams
BACKGROUND: A text messaging service (short message service [SMS]) has the potential to target large groups of people with long-term illnesses such as serious mental disorders, who may have difficulty with treatment adherence. Robust research on the impact of mobile technology interventions for these patients remains scarce. OBJECTIVE: The main objective of our study was to investigate the impact of individually tailored short text messages on the rate of psychiatric hospital readmissions, health care service use, and clinical outcomes...
July 12, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28701290/using-new-and-emerging-technologies-to-identify-and-respond-to-suicidality-among-help-seeking-young-people-a-cross-sectional-study
#12
Frank Iorfino, Tracey A Davenport, Laura Ospina-Pinillos, Daniel F Hermens, Shane Cross, Jane Burns, Ian B Hickie
BACKGROUND: Suicidal thoughts are common among young people presenting to face-to-face and online mental health services. The early detection and rapid response to these suicidal thoughts and other suicidal behaviors is a priority for suicide prevention and early intervention efforts internationally. Establishing how best to use new and emerging technologies to facilitate person-centered systematic assessment and early intervention for suicidality is crucial to these efforts. OBJECTIVE: The aim of this study was to examine the use of a suicidality escalation protocol to respond to suicidality among help-seeking young people...
July 12, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28701275/is-going-into-stable-symptomatic-remission-associated-with-a-more-positive-development-of-life-satisfaction-a-10-year-follow-up-study-of-first-episode-psychosis
#13
Erlend Strand Gardsjord, Kristin Lie Romm, Jan Ivar Røssberg, Svein Friis, Helene Eidsmo Barder, Julie Evensen, Ulrik Haahr, Wenche Ten Velden Hegelstad, Inge Joa, Jan Olav Johannessen, Johannes Langeveld, Tor Ketil Larsen, Stein Opjordsmoen, Bjørn Rishovd Rund, Erik Simonsen, Per Vaglum, Thomas McGlashan, Ingrid Melle
BACKGROUND: Quality of life is an important outcome measure for patients with psychosis. We investigated whether going into stable symptomatic remission is associated with a more positive development of subjective quality of life (S-QoL) and if different patient characteristics are associated with S-QoL depending on remission status. METHODS: Three hundred and one patients with a first-episode psychosis were included at baseline. At 10-year follow-up 186 were reassessed...
July 9, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28699248/phenotypical-characteristics-of-postpartum-psychosis-a-clinical-cohort-study
#14
Astrid M Kamperman, Marian J Veldman-Hoek, Richard Wesseloo, Emma Robertson Blackmore, Veerle Bergink
OBJECTIVES: Postpartum psychosis (PP) is known for its clear onset but its phenotype has never been clearly described in a cohort. The aim of this study was to describe PP symptomatology, and to identify subgroups of patients based on symptom profiles. METHODS: We prospectively assessed a wide range of symptoms in cases of PP in a cohort of women (N=130) admitted to the Mother-Baby inpatient unit. Using a person-centered analytic approach, we distinguished mutually exclusive subgroups of women...
July 12, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28697856/demographic-and-clinical-correlates-of-substance-use-disorders-in-first-episode-psychosis
#15
Mary F Brunette, Kim T Mueser, Steven Babbin, Piper Meyer-Kalos, Robert Rosenheck, Christoph U Correll, Corrine Cather, Delbert G Robinson, Nina R Schooler, David L Penn, Jean Addington, Sue E Estroff, Jennifer Gottlieb, Shirley M Glynn, Patricia Marcy, James Robinson, John M Kane
BACKGROUND: We assessed the prevalence and correlates of lifetime substance use disorders in people with first episode psychosis using the baseline data from the Recovery After an Initial Schizophrenia Episode (RAISE) Early Treatment Program study. METHODS: Research staff assessed 404 first episode patients at 34 community mental health centers across the United States with the Structured Clinical Interview for DSM-IV for diagnoses of psychotic and substance use disorders...
July 8, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28688741/stronger-default-mode-network-connectivity-is-associated-with-poorer-clinical-insight-in-youth-at-ultra-high-risk-for-psychotic-disorders
#16
Sarah V Clark, Vijay A Mittal, Jessica A Bernard, Aral Ahmadi, Tricia Z King, Jessica A Turner
Impaired clinical insight (CI) is a common symptom of psychotic disorders and a promising treatment target. However, to date, our understanding of how variability in CI is tied to underlying brain dysfunction in the clinical high-risk period is limited. Developing a stronger conception of this link will be a vital first step for efforts to determine if CI can serve as a useful prognostic indicator. The current study investigated whether variability in CI is related to major brain networks in adolescents and young adults at ultra high-risk (UHR) of developing psychosis...
July 5, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28688350/changes-in-the-cytokine-profile-in-first-episode-drug-na%C3%A3-ve-patients-with-psychosis-after-short-term-antipsychotic-treatment
#17
Petros Petrikis, Paraskevi V Voulgari, Alexandros T Tzallas, Vassiliki A Boumba, Dimitra T Archimandriti, Dimitrios Zambetas, Ioannis Papadopoulos, Ioannis Tsoulos, Petros Skapinakis, Venetsanos Mavreas
An increasing body of evidence suggests that antipsychotic medication can cause immunological changes that could be attributed to the amelioration of psychotic symptoms or the metabolic side effects of the drugs. So far, the results of the studies remain controversial. Our aim was to compare the levels of interleukin (IL) IL-2, IL-6 and transforming growth factor-β2 (TGF-β2) in drug-naïve, first-episode patients with psychosis before and after six weeks of antipsychotic medication. Thirty-nine first-episode patients with psychosis were enrolled in the study...
July 3, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28688266/neural-hormonal-responses-to-negative-affective-stimuli-impact-of-dysphoric-mood-and-sex
#18
K Mareckova, L Holsen, R Admon, S Whitfield-Gabrieli, L J Seidman, S L Buka, A Klibanski, J M Goldstein
BACKGROUND: Maladaptive responses to negative affective stimuli are pervasive, including clinically ill and healthy people, and men and women respond differently at neural and hormonal levels. Inspired by the Research Domain Criteria initiative, we used a transdiagnostic approach to investigate the impact of sex and dysphoric mood on neural-hormonal responses to negative affective stimuli. METHODS: Participants included 99 individuals with major depressive disorder, psychosis and healthy controls...
June 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28678220/neuropsychiatric-and-neurological-problems-among-vitamin-b12-deficient-young-vegetarians
#19
Aneel Kapoor, Mukhtiar Baig, Saeed A Tunio, Abdul S Memon, Hotchand Karmani
OBJECTIVE: To assess the frequency of neuropsychiatric and neurological problems in apparently healthy young vegetarians and estimate serum Vitamin B12, methylmalonic acid (MMA), and folic acid levels. METHODS: This prospective study was conducted in the Department of Biochemistry, Basic Medical Sciences Institute (BMSI), Jinnah Postgraduate Medical Center (JPMC), Karachi, Pakistan, in the years of 2012 and 2013. The data of 100 vegetarians and 100 omnivores were analyzed and compared...
July 2017: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/28676240/local-nmda-receptor-hypofunction-evokes-generalized-effects-on-gamma-and-high-frequency-oscillations-and-behavior
#20
Jaime Lee, Matthew R Hudson, Terence J O'Brien, Jess Nithianantharajah, Nigel C Jones
The NMDA receptor (NMDAr) hypofunction theory of schizophrenia suggests that aberrant signaling through NMDAr underlies the pathophysiology of this disease. This is commonly modeled in rodents via treatment with NMDAr antagonists, which causes a range of behavioral effects that represent endophenotypes related to schizophrenia. These drugs also disrupt high-frequency neural oscillations within the brain, also potentially relevant to disease. We studied the effect of localized NMDAr hypofunction on the generation of neural oscillations occurring both locally and in distant brain regions, and on behaviors routinely used as endophenotypes to model psychosis in rodents...
July 1, 2017: Neuroscience
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