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Assessment dementia

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https://www.readbyqxmd.com/read/28933190/assessment-of-capabilities-in-persons-with-advanced-stage-of-dementia-validation-of-the-montessori-assessment-system-mas
#1
Jérôme Erkes, Cameron J Camp, Stéphane Raffard, Marie-Christine Gély-Nargeot And, Sophie Bayard
This study evaluated the validity and reliability of the Montessori Assessment System. The Montessori Assessment System assesses preserved abilities in persons with moderate to severe dementia. In this respect, this instrument provides crucial information for the development of effective person-centered care plans. A total of 196 persons with a diagnosis of dementia in the moderate to severe stages of dementia were recruited in 10 long-term care facilities in France. All participants completed the Montessori Assessment System, the Clinical Dementia Rating Scale and/or the Mini Mental State Examination and the Severe Impairment Battery-short form...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/28931509/development-and-validation-of-qmortality-risk-prediction-algorithm-to-estimate-short-term-risk-of-death-and-assess-frailty-cohort-study
#2
Julia Hippisley-Cox, Carol Coupland
Objectives To derive and validate a risk prediction equation to estimate the short term risk of death, and to develop a classification method for frailty based on risk of death and risk of unplanned hospital admission.Design Prospective open cohort study.Participants Routinely collected data from 1436 general practices contributing data to QResearch in England between 2012 and 2016. 1079 practices were used to develop the scores and a separate set of 357 practices to validate the scores. 1.47 million patients aged 65-100 years were in the derivation cohort and 0...
September 20, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28931452/factors-associated-with-appropriate-psychotropic-drug-prescription-in-nursing-home-patients-with-severe-dementia
#3
Klaas van der Spek, Raymond Tcm Koopmans, Martin Smalbrugge, Marjorie Hjmg Nelissen-Vrancken, Roland B Wetzels, Claudia Hw Smeets, Steven Teerenstra, Sytse U Zuidema, Debby L Gerritsen
BACKGROUND: We studied the patient and non-patients factors of inappropriate psychotropic drug (PD) prescription for neuropsychiatric symptoms (NPS) in nursing home patients with severe dementia. METHODS: In a cross-sectional study, the appropriateness of prescriptions was explored using the Appropriate Psychotropic drug use In Dementia (APID) index sum score. This index assesses information from medical records on indication, evaluation, dosage, drug-drug interactions, drug-disease interactions, duplications, and therapy duration...
September 21, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28931446/prevalence-estimates-of-mild-behavioral-impairment-in-a-population-based-sample-of-pre-dementia-states-and-cognitively-healthy-older-adults
#4
Moyra E Mortby, Zahinoor Ismail, Kaarin J Anstey
BACKGROUND: A dearth of population-based epidemiological research examines neuropsychiatric symptom (NPS) in sub-clinical populations across the spectrum from normal aging to mild cognitive impairment (MCI). The construct of mild behavioral impairment (MBI) describes the emergence of sustained and impactful NPS in advance of or in combination with MCI. This is the first epidemiological study to operationalize the recently published diagnostic criteria for MBI and determine prevalence estimates across the spectrum from cognitively normal to MCI...
September 21, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28931444/treatment-effects-of-ginkgo-biloba-extract-egb-761%C3%A2-on-the-spectrum-of-behavioral-and-psychological-symptoms-of-dementia-meta-analysis-of-randomized-controlled-trials
#5
Egemen Savaskan, Heiko Mueller, Robert Hoerr, Armin von Gunten, Serge Gauthier
BACKGROUND: In randomized controlled trials, Ginkgo biloba extract EGb 761® has been found to be effective in the treatment of behavioral and psychological symptoms of dementia (BPSD). METHODS: To assess the effects of EGb 761® on specific BPSD, we analyzed data from all randomized, placebo-controlled, at least 20-week, trials of EGb 761® enrolling patients with dementia (probable Alzheimer's disease (AD), probable vascular dementia or probable AD with cerebrovascular disease) who had clinically significant BPSD (Neuropsychiatric Inventory (NPI) total score at least 6)...
September 21, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28931443/conversational-assessment-of-cognitive-dysfunction-among-residents-living-in-long-term-care-facilities
#6
Hikaru Oba, Shinichi Sato, Hiroaki Kazui, Yoshiko Nitta, Tatsuya Nashitani, Akio Kamiyama
BACKGROUND: There are some existing barriers posed by neuropsychological tests that interfere with the assessment of cognitive functioning by staff who work in long-term care facilities. The purpose of this study was to investigate the feasibility of assessing cognitive function through conversation. METHODS: A total of 100 care staff was randomly selected as participants. Each staff member evaluated cognitive function in one to three residents using the Conversational Assessment of Neurocognitive Dysfunction (CANDy), which is a screening test for dementia using conversation...
September 21, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28931301/oxidative-stress-assessment-in-alzheimer-s-disease-a-clinic-setting-study
#7
Andrea Vergallo, Linda Giampietri, Filippo Baldacci, Leda Volpi, Lucia Chico, Cristina Pagni, Filippo Sean Giorgi, Roberto Ceravolo, Gloria Tognoni, Gabriele Siciliano, Ubaldo Bonuccelli
BACKGROUND: Oxidative stress (OS) is a physiological age-related brain process, dramatically overexpressed in neurodegenerative disorders like Alzheimer's disease (AD). Nevertheless, the pathophysiological role of OS in AD pathology has not been clarified yet. OS as a biomarker for AD is a controversial issue. A comparison of previous data is difficult due to a remarkable methodological variability. Most of the previous studies have shown higher levels of OS markers and lower antioxidant power in patients with dementia when compared to mild cognitive impairment (MCI) and healthy controls...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28929900/a-review-of-canadian-and-international-dementia-strategies
#8
Cole Edick, Nicole Holland, Jessica Ashbourne, Jacobi Elliott, Paul Stolee
To inform future strategy development in Canada and other jurisdictions, we undertook an Internet search to identify existing national and Canadian provincial dementia strategies and their major themes. Twenty-two dementia strategies were identified through an Internet search, supplemented by hand searches of reference lists of retrieved documents. Thematic analysis identified 17 strategic themes; common themes included improved diagnoses and assessments, increased access to care, and improved education of the healthcare workforce...
January 2017: Healthcare Management Forum
https://www.readbyqxmd.com/read/28929833/the-alzheimer-s-disease-metabolic-brain-pattern-in-mild-cognitive-impairment
#9
Sanne K Meles, Marco Pagani, Dario Arnaldi, Fabrizio De Carli, Barbara Dessi, Silvia Morbelli, Gianmario Sambuceti, Cathrine Jonsson, Klaus L Leenders, Flavio Nobili
We investigated the expression of the Alzheimer's disease-related metabolic brain pattern (ADRP) in (18)F-FDG-PET scans of 44 controls, 27 patients with mild cognitive impairment (MCI) who did not convert to Alzheimer's disease (AD) after five or more years of clinical follow-up, 95 MCI patients who did develop AD dementia on clinical follow-up, and 55 patients with mild-to-moderate AD. The ADRP showed good sensitivity (84%) and specificity (86%) for MCI-converters when compared to controls, but limited specificity when compared to MCI non-converters (66%)...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28929475/-mild-behavioural-impairment-as-an-antecedent-of-dementia-presentation-of-the-diagnostic-criteria-and-the-spanish-version-of-the-mbi-c-scale-for-its-evaluation
#10
REVIEW
L F Aguera-Ortiz, J Lopez-Alvarez, L Del Nido-Varo, E Soria Garcia-Rosel, D A Perez-Martinez, Z Ismail
INTRODUCTION: Neuropsychiatric symptoms are common in dementia and also in previous stages such as mild cognitive impairment. Their presence is related to greater conversion to dementia in cognitively healthy people or with mild cognitive impairment compared to those who do not suffer them. AIM: An international working group pertaining to the Alzheimer Association has proposed the concept of 'mild behavioral impairment' (MBI) to identify patients with mild neuropsychiatric symptoms and normal cognition or mild cognitive impairment and to study the further risk of developing dementia from any cause...
October 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28927483/the-impact-of-younger-onset-dementia-on-relationships-intimacy-and-sexuality-in-midlife-couples-a-systematic-review
#11
Kristen Holdsworth, Marita McCabe
BACKGROUND: The impact of dementia on relationships, intimacy, and sexuality has been documented in later life couples. However, little is known about the experiences of couples living with younger-onset dementia. The aim of this systematic review was to analyze the literature describing the impact of younger-onset dementia on relationships, intimacy, and sexuality in midlife couples. METHODS: A systematic literature search was conducted in July 2016 for relevant research papers...
September 20, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28927479/insomnia-symptoms-among-old-people-in-nursing-homes
#12
Andreas Skottheim, Hugo Lövheim, Ulf Isaksson, Per-Olof Sandman, Maria Gustafsson
BACKGROUND: Insomnia symptoms are common among old people, and hypnotics and sedative drugs are often prescribed in spite of small benefits. The aim of this study was to estimate the prevalence of insomnia symptoms and to analyze the association between insomnia symptoms, cognitive level, and prescription of hypnotics and sedatives among old people living in nursing homes. METHODS: The study comprised 2,135 people living in nursing homes in the county of Västerbotten, Sweden...
September 20, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28926815/cognitive-function-and-walking-velocity-in-people-with-dementia-a-comparison-of-backward-and-forward-walking
#13
Hanna Johansson, Lillemor Lundin-Olsson, Håkan Littbrand, Yngve Gustafson, Erik Rosendahl, Annika Toots
How forward and backward walking, both central to everyday life, relate to cognition are relatively unexplored in people with dementia. This study aimed to investigate if forward and backward walking velocity respectively, associated with global cognition and executive function in people with dementia, and whether the association differed according to walking aid use or dementia type. Using a cross-sectional design, 161 participants (77% women), a mean Mini-Mental State Examination (MMSE) score of 15, and mean age of 85...
September 9, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28926415/semantic-memory-in-the-clinical-progression-of-alzheimer-disease
#14
Christophe T Tchakoute, Kristin L Sainani, And Victor W Henderson
BACKGROUND AND OBJECTIVE: Semantic memory measures may be useful in tracking and predicting progression of Alzheimer disease. We investigated relationships among semantic memory tasks and their 1-year predictive value in women with Alzheimer disease. METHODS: We conducted secondary analyses of a randomized clinical trial of raloxifene in 42 women with late-onset mild-to-moderate Alzheimer disease. We assessed semantic memory with tests of oral confrontation naming, category fluency, semantic recognition and semantic naming, and semantic density in written narrative discourse...
September 2017: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/28925598/atrophy-of-the-parahippocampal-gyrus-is-prominent-in-heart-failure-patients-without-dementia
#15
Tomomi Meguro, Yuko Meguro, Takeyoshi Kunieda
AIMS: The exacerbation of heart failure (HF) induces brain damage and cognitive impairment (CI), which frequently attenuates the effects of treatment. However, it is not clear whether HF patients without clinical dementia demonstrate increased risk of CI. We examined whether local atrophy in the parahippocampal gyrus, a potential predictor of CI, is prominent in HF patients without clinical dementia. METHODS AND RESULTS: Twenty stable HF patients with a history of admission due to decompensated HF or presentation of apparent pulmonary congestion following chest X-ray and 17 controls were enrolled in this observational, analytical, cross-sectional, case-control study...
July 17, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28925333/depression-and-cognitive-function-in-mild-cognitive-impairment-a-1-year-follow-up-study
#16
Seoyoung Yoon, Cheolmin Shin, Changsu Han
BACKGROUND: The coexistence of depression with mild cognitive impairment (MCI) seems to increase the risk of dementia. However, the explanations of that relationship have been inconsistent. We investigated cognitive profiles in patients with MCI with and without depression and whether changes in depression symptoms affect cognition longitudinally. METHODS: For the study, 161 patients with MCI were divided into a depressed group (D+) and a nondepressed group (D-)...
September 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28924156/primary-and-secondary-non-adherence-to-osteoporotic-medications-after-hip-fracture-in-spain-the-prev2fo-population-based-retrospective-cohort-study
#17
Aníbal García-Sempere, Isabel Hurtado, José Sanfélix-Genovés, Clara L Rodríguez-Bernal, Rafael Gil Orozco, Salvador Peiró, Gabriel Sanfélix-Gimeno
Osteoporotic medication after hip fracture is widely recommended by clinical practice guidelines, and medication adherence is essential to meet clinical trial risk reduction figures in the real world. We assessed primary and secondary non-adherence to osteoporosis medications in patients discharged following a hip fracture and identified factors associated with secondary non-adherence. From a population-based retrospective cohort of 19,405 patients aged 65 years and over discharged from a hip fracture in the region of Valencia (Spain) from January 1, 2008 and June 30, 2012, we followed, over a minimum of 365 days, 4,856 patients with at least one osteoporotic medication prescribed within the first six months after discharge...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28924012/inhibition-of-il-1%C3%AE-signaling-normalizes-nmda-dependent-neurotransmission-and-reduces-seizure-susceptibility-in-a-mouse-model-of-creutzfeldt-jakob-disease
#18
Ilaria Bertani, Valentina Iori, Massimo Trusel, Mattia Maroso, Claudia Foray, Susanna Mantovani, Raffaella Tonini, Annamaria Vezzani, Roberto Chiesa
Creutzfeldt-Jakob disease (CJD) is a neurodegenerative disorder caused by prion protein (PrP) misfolding, clinically recognized by cognitive and motor deficits, electroencephalographic (EEG) abnormalities and seizures. Its neurophysiological bases are not known. To assess the potential involvement of N-methyl-D-aspartate receptor (NMDAR) dysfunction, we analyzed NMDA-dependent synaptic plasticity in hippocampal slices from Tg(CJD) mice, which model a genetic form of CJD. Because PrP depletion may result in functional upregulation of NMDARs, we also analyzed PrP knockout (KO) mice...
September 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28923236/emergency-nurses-knowledge-and-self-rated-practice-skills-when-caring-for-older-patients-in-the-emergency-department
#19
Helen Rawson, Paul N Bennett, Cherene Ockerby, Alison M Hutchinson, Julie Considine
BACKGROUND: Older adults are high users of emergency department services and their care requirements can present challenges for emergency nurses. Although clinical outcomes for older patients improve when they are cared for by nurses with specialist training, emergency nurses' knowledge and self-assessment of care for older patients is poorly understood. AIM: To assess emergency nurses' knowledge and self-rating of practice when caring for older patients. METHODS: A cross-sectional self-report survey of emergency nurses (n=101) in Melbourne, Australia...
September 8, 2017: Australasian Emergency Nursing Journal: AENJ
https://www.readbyqxmd.com/read/28922625/living-and-dying-with-advanced-dementia-a-prospective-cohort-study-of-symptoms-service-use-and-care-at-the-end-of-life
#20
Elizabeth L Sampson, Bridget Candy, Sarah Davis, Anna Buylova Gola, Jane Harrington, Michael King, Nuriye Kupeli, Gerry Leavey, Kirsten Moore, Irwin Nazareth, Rumana Z Omar, Victoria Vickerstaff, Louise Jones
BACKGROUND: Increasing number of people are dying with advanced dementia. Comfort and quality of life are key goals of care. AIMS: To describe (1) physical and psychological symptoms, (2) health and social care service utilisation and (3) care at end of life in people with advanced dementia. DESIGN: 9-month prospective cohort study. SETTING AND PARTICIPANTS: Greater London, England, people with advanced dementia (Functional Assessment Staging Scale 6e and above) from 14 nursing homes or their own homes...
August 1, 2017: Palliative Medicine
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