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Bolla trial

Michèle Muller-Bolla, Fréderic Courson, Laurence Lupi-Pégurier, Corinne Tardieu, Shrisha Mohit, Pascal Staccini, Ana Miriam Velly
A split-mouth randomized clinical trial was carried out to assess the effectiveness of sealants in preventing carious ICDAS (International Caries Detection and Assessment System) 3-6 lesions within a 2-year follow-up. We evaluated the effectiveness of 2 types of resin-based sealants, with and without fluoride, their retention rates, and the caries risk factors related to their outcomes. The study included 663 tooth pairs in 400 children (aged 5-15 years) considered to be at high individual caries risk (ICR) and presenting permanent molars free of caries or affected by ICDAS 1-2 lesions...
March 1, 2018: Caries Research
Bollu Indira Priyadarshini, Thumu Jayaprakash, Bolla Nagesh, Chukka Ram Sunil, Varri Sujana, Velagala L Deepa
Aim: The purpose of this study was to evaluate the clinical performance of Ketac Nano (Ketac™ N100), RMGIC (Fuji Filling™ LC), and Giomer (Beautifil® II) in noncarious cervical lesions (NCCLs). Materials and Methods: One operator restored 120 NCCLs in 20 subjects, with at least two lesions restored with one of the restorative materials: RMGIC (control group), Giomer and Ketac Nano (experimental groups). Two observers evaluated retention, marginal discoloration, marginal adaptation, color match, surface roughness, and postoperative sensitivity using modified USPHS criteria at baseline, 6, and 12 months...
May 2017: Journal of Conservative Dentistry: JCD
Michael Lardas, Matthew Liew, Roderick C van den Bergh, Maria De Santis, Joaquim Bellmunt, Thomas Van den Broeck, Philip Cornford, Marcus G Cumberbatch, Nicola Fossati, Tobias Gross, Ann M Henry, Michel Bolla, Erik Briers, Steven Joniau, Thomas B Lam, Malcolm D Mason, Nicolas Mottet, Henk G van der Poel, Olivier Rouvière, Ivo G Schoots, Thomas Wiegel, Peter-Paul M Willemse, Cathy Yuhong Yuan, Liam Bourke
CONTEXT: Current evidence-based management for clinically localised prostate cancer includes active surveillance, surgery, external beam radiotherapy (EBRT) and brachytherapy. The impact of these treatment modalities on quality of life (QoL) is uncertain. OBJECTIVE: To systematically review comparative studies investigating disease-specific QoL outcomes as assessed by validated cancer-specific patient-reported outcome measures with at least 1 yr of follow-up after primary treatment for clinically localised prostate cancer...
December 2017: European Urology
Shalini Chandrasekhar, Ghanashyam Prasad Madu, Naga Radhakrishna Ambati, Pavani Reddy Suravarapu, Kalyani Uppu, Deepthi Bolla
STATEMENT OF THE PROBLEM: Hearing impaired children have a problem in understanding and comprehending with dental treatments. Visual language is the sensible answer of how to improve communication with them. PURPOSE: To evaluate the applicability of dental sign language in Hearing impaired children in relieving anxiety during stressful dental treatment by improving their means of communication. MATERIALS AND METHOD: This randomized clinical trial was carried out in the Department of Pedodontics and Preventive Dentistry which included 40 Hearing Impaired children meeting inclusion criteria...
June 2017: Journal of Dentistry
Marieke van Leeuwen, Jacobien M Kieffer, Fabio Efficace, Sophie D Fosså, Michel Bolla, Laurence Collette, Marc Colombel, Ugo De Giorgi, Bernhard Holzner, Lonneke V van de Poll-Franse, Hendrik van Poppel, Jeff White, Ronald de Wit, Susanne Osanto, Neil K Aaronson
BACKGROUND: Understanding of the physical, functional and psychosocial health problems and needs of cancer survivors requires cross-national and cross-cultural standardization of health-related quality of life (HRQoL) questionnaires that capture the full range of issues relevant to cancer survivors. To our knowledge, only one study has investigated in a comprehensive way whether a questionnaire used to evaluate HRQoL in cancer patients under active treatment is also reliable and valid when used among (long-term) cancer survivors...
May 11, 2017: Health and Quality of Life Outcomes
Nicola Fossati, Peter-Paul M Willemse, Thomas Van den Broeck, Roderick C N van den Bergh, Cathy Yuhong Yuan, Erik Briers, Joaquim Bellmunt, Michel Bolla, Philip Cornford, Maria De Santis, Ekelechi MacPepple, Ann M Henry, Malcolm D Mason, Vsevolod B Matveev, Henk G van der Poel, Theo H van der Kwast, Olivier Rouvière, Ivo G Schoots, Thomas Wiegel, Thomas B Lam, Nicolas Mottet, Steven Joniau
CONTEXT: There is controversy regarding the therapeutic role of pelvic lymph node dissection (PLND) in patients undergoing radical prostatectomy for prostate cancer (PCa). OBJECTIVE: To systematically review the relevant literature assessing the relative benefits and harms of PLND for oncological and non-oncological outcomes in patients undergoing radical prostatectomy for PCa. EVIDENCE ACQUISITION: MEDLINE, MEDLINE In-Process, Embase, and the Cochrane Central Register of Controlled Trials were searched up to December 2015...
January 24, 2017: European Urology
Marc Bolla, Michele Muller-Bolla, Cybele Borg, Laurence Lupi-Pegurier, Olivier Laplanche, Eric Leforestier
BACKGROUND: The foundation for the reconstruction of endodontically-treated teeth can be provided by a metal or a non-metal post and core system but no guidelines exist for choosing one or the other in particular clinical cases. OBJECTIVES: To assess the effectiveness of different post and core systems for the restoration of endodontically-treated teeth. The primary objective of this review was to compare the clinical failure rates of the different types of posts...
November 28, 2016: Cochrane Database of Systematic Reviews
Sophie Doméjean, Julie Rongier, Michéle Muller-Bolla
The aim of this systematic review was to assess the in vivo scientific evidence regarding the ability of a recently developed light fluorescence device, SoproLife(®) (Sopro-Acteon group, La Ciotat, France) in detecting occlusal carious lesions. The PubMed database was searched for in vivo trials that evaluated the validity of the SoproLife(®) camera for the detection of occlusal carious lesions. Among the 11 articles originally identified with the keyword "Soprolife," only three articles were included. The three included surveys used the International Caries Detection and Assessment System (ICDAS)-II criteria as gold standard for the assessment of SoproLife(®) compared or not to other detection devices (DIAGNOdent(®) and Spectra Caries Detection Aid(®))...
September 1, 2016: Journal of Contemporary Dental Practice
Elody Aiem, Violaine Smaïl-Faugeron, Michèle Muller-Bolla
BACKGROUND: Different aesthetic preformed crowns (APC) are proposed to restore decayed and damaged primary teeth because the stainless steel crowns (SSCs) do not satisfy parents concerned about aesthetic. AIM: The objective was to evaluate the clinical effectiveness of all types of APC for restoring primary teeth compared with conventional filling materials or other types of crowns. DESIGN: Relevant articles were searched in electronic databases of PubMed via MEDLINE and the Cochrane central register of controlled trials...
July 2017: International Journal of Paediatric Dentistry
Cyril Villat, Jean-Pierre Attal, Nathalie Brulat, Franck Decup, Sophie Doméjean, Elisabeth Dursun, Hélène Fron-Chabouis, Bruno Jacquot, Michèle Muller Bolla, Nelly Plasse-Pradelle, Laurent Roche, Delphine Maucort-Boulch, Patrice Nony, Kerstin Gritsch, Pierre Millet, François Gueyffier, Brigitte Grosgogeat
BACKGROUND: Current concepts in conservative dentistry advocate minimally invasive dentistry and pulp vitality preservation. Moreover, complete removal of carious dentin in deep carious lesions often leads to pulp exposure and root canal treatment, despite the absence of irreversible pulp inflammation. For years, partial caries removal has been performed on primary teeth, but little evidence supports its effectiveness for permanent teeth. Furthermore, the recent development of new antibacterial adhesive systems could be interesting in the treatment of such lesions...
August 15, 2016: Trials
V Smaïl-Faugeron, A Porot, M Muller-Bolla, F Courson
AIM: To assess dental practice regarding the use of indirect pulp capping or pulpotomy in children with deep carious lesions approaching the pulp in primary teeth and to compare the efficacy of the two pulp treatments. METHODS: HASH(0x4011be8) STUDY DESIGN: Systematic review. We searched the Cochrane Library, PubMed via MEDLINE, and EMBASE as well as the reference lists of included reports and (for ongoing trials). Eligible studies were surveys of dental practice sent to dentists regarding the use of indirect pulp capping and pulpotomy in children with deep carious lesions approaching the pulp in primary teeth and any type of clinical study...
June 2016: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
Michèle Muller-Bolla, Audrey Pierre, Laurence Lupi-Pégurier, Ana M Velly
AIM: A split-mouth randomized clinical trial was carried out to assess the effectiveness of a school-based dental sealant (SBDS) program for French children from low-income backgrounds within 3 years of follow-up. The secondary objectives were to determine the risk factors for the occurrence of new carious lesions (ICDAS 3-6) on first permanent molars, to evaluate the effectiveness of the program according to risk factors and to assess sealant retention. METHODS: The study included 276 6- to 7-year old pupils (457 pairs of first permanent molars) from Nice...
October 2016: Community Dentistry and Oral Epidemiology
Soumya Penala, Butchibabu Kalakonda, Krishnajaneya Reddy Pathakota, Avula Jayakumar, Pradeep Koppolu, Bolla Vijaya Lakshmi, Ruchi Pandey, Ashank Mishra
OBJECTIVE: Periodontitis is known to have multifactorial etiology, involving interplay between environmental, host and microbial factors. The current treatment approaches are aimed at reducing the pathogenic microorganisms. Administration of beneficial bacteria (probiotics) has emerged as a promising concept in the prevention and treatment of periodontitis. Thus, the aim of the present study is to evaluate the efficacy of the local use of probiotics as an adjunct to scaling and root planing (SRP) in the treatment of patients with chronic periodontitis and halitosis...
April 2016: Journal of Research in Pharmacy Practice
Michel Bolla, Philippe Maingon, Christian Carrie, Salvador Villa, Petros Kitsios, Philip M P Poortmans, Santhanam Sundar, Elzbieta M van der Steen-Banasik, John Armstrong, Jean-François Bosset, Fernanda G Herrera, Bradley Pieters, Annerie Slot, Amit Bahl, Rahamim Ben-Yosef, Dirk Boehmer, Christopher Scrase, Laurette Renard, Emad Shash, Corneel Coens, Alphonsus C M van den Bergh, Laurence Collette
PURPOSE: Up to 30% of patients who undergo radiation for intermediate- or high-risk localized prostate cancer relapse biochemically within 5 years. We assessed if biochemical disease-free survival (DFS) is improved by adding 6 months of androgen suppression (AS; two injections of every-3-months depot of luteinizing hormone-releasing hormone agonist) to primary radiotherapy (RT) for intermediate- or high-risk localized prostate cancer. PATIENTS AND METHODS: A total of 819 patients staged: (1) cT1b-c, with prostate-specific antigen (PSA) ≥ 10 ng/mL or Gleason ≥ 7, or (2) cT2a (International Union Against Cancer TNM 1997), with no involvement of pelvic lymph nodes and no clinical evidence of metastatic spread, with PSA ≤ 50 ng/mL, were centrally randomized 1:1 to either RT or RT plus AS started on day 1 of RT...
May 20, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Violaine Smaïl-Faugeron, Michèle Muller-Bolla, Jean-Louis Sixou, Frédéric Courson
INTRODUCTION: Local anaesthesia is commonly used in paediatric oral healthcare. Infiltration anaesthesia is the most frequently used, but recent developments in anaesthesia techniques have introduced an alternative: intraosseous anaesthesia. We propose to perform a split-mouth and parallel-arm multicentre randomised controlled trial (RCT) comparing the pain caused by the insertion of the needle for the injection of conventional infiltration anaesthesia, and intraosseous anaesthesia by the computerised QuickSleeper system, in children and adolescents...
July 10, 2015: BMJ Open
Violaine Smaïl-Faugeron, Frédéric Courson, Pierre Durieux, Michele Muller-Bolla, Anne-Marie Glenny, Helene Fron Chabouis
BACKGROUND: In children, dental caries is among the most prevalent chronic diseases worldwide. Pulp interventions are indicated for extensive tooth decay. Depending on the severity of the disease, three pulp treatment techniques are available: direct pulp capping, pulpotomy and pulpectomy. After treatment, the cavity is filled with a medicament.This is an update of a Cochrane review first published in 2003. The previous review found insufficient evidence regarding the relative efficacy of these interventions, combining one pulp treatment technique and one medicament...
2014: Cochrane Database of Systematic Reviews
Marieke van Leeuwen, Fabio Efficace, Sophie D Fosså, Michel Bolla, Ugo De Giorgi, Ronald de Wit, Bernhard Holzner, Lonneke V van de Poll-Franse, Hendrik van Poppel, Jeff White, Laurence Collette, Susanne Osanto, Neil K Aaronson
OBJECTIVES: In this pilot study we evaluated the feasibility of and methods for assessing the quality of life of long term survivors of European Organisation for Research and Treatment of Cancer (EORTC) phase III clinical trials. Here we report the results pertaining to the feasibility of conducting such research. METHODS: In this cross-sectional study, we recruited long-term, disease-free survivors from two mature EORTC clinical trials in testicular and prostate cancer from centres in Northern and Southern Europe, and the United Kingdom (UK)...
July 2014: European Journal of Cancer
Mark A Ritter
BACKGROUND: We report the long-term results of a trial of immediate postoperative irradiation versus a wait-and-see policy in patients with prostate cancer extending beyond the prostate, to confirm whether previously reported progression-free survival was sustained. METHODS: This randomised, phase 3, controlled trial recruited patients aged 75 years or younger with untreated cT0-3 prostate cancer (WHO performance status 0 or 1) from 37 institutions across Europe...
April 2014: Urologic Oncology
Jean-François Bosset, Gilles Calais, Laurent Mineur, Philippe Maingon, Suzana Stojanovic-Rundic, René-Jean Bensadoun, Etienne Bardet, Alexander Beny, Jean-Claude Ollier, Michel Bolla, Dominique Marchal, Jean-Luc Van Laethem, Vincent Klein, Jordi Giralt, Pierre Clavère, Christoph Glanzmann, Patrice Cellier, Laurence Collette
BACKGROUND: EORTC trial 22921 examined the addition of preoperative or postoperative chemotherapy to preoperative radiotherapy in patients with rectal cancer. After a median follow-up of 5 years, chemotherapy-irrespective of timing-significantly improved local control. Adjuvant chemotherapy did not improve survival, but the Kaplan-Meier curves diverged, suggesting possible delayed benefit. Here, we report the updated long-term results. METHODS: We randomly assigned patients with clinical stage T3 or T4 resectable rectal cancer to receive preoperative radiotherapy with or without concomitant chemotherapy before surgery followed by either adjuvant chemotherapy or surveillance...
February 2014: Lancet Oncology
Axel Heidenreich, Patrick J Bastian, Joaquim Bellmunt, Michel Bolla, Steven Joniau, Theodor van der Kwast, Malcolm Mason, Vsevolod Matveev, Thomas Wiegel, F Zattoni, Nicolas Mottet
CONTEXT: The most recent summary of the European Association of Urology (EAU) guidelines on prostate cancer (PCa) was published in 2011. OBJECTIVE: To present a summary of the 2013 version of the EAU guidelines on screening, diagnosis, and local treatment with curative intent of clinically organ-confined PCa. EVIDENCE ACQUISITION: A literature review of the new data emerging from 2011 to 2013 has been performed by the EAU PCa guideline group...
January 2014: European Urology
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