keyword
https://read.qxmd.com/read/38535039/differential-effects-of-a-telemonitoring-platform-in-the-development-of-chemotherapy-associated-toxicity-a-randomized-trial-protocol
#1
JOURNAL ARTICLE
Felipe Martínez, Carla Taramasco, Manuel Espinoza, Johanna Acevedo, Carolina Goic, Bruno Nervi
Chemotherapy requires careful monitoring, but traditional follow-up approaches face significant challenges that were highlighted by the COVID-19 pandemic. Hence, exploration into telemonitoring as an alternative emerged. The objective is to assess the impact of a telemonitoring platform that provides clinical data to physicians overseeing solid tumor patients, aiming to enhance the care experience. The methodology outlines a parallel-group randomized clinical trial involving recently diagnosed patients with solid carcinomas preparing for curative intent chemotherapy...
March 14, 2024: Diagnostics
https://read.qxmd.com/read/38534920/sex-based-analysis-of-quality-indicators-of-end-of-life-care-in-gastrointestinal-malignancies
#2
JOURNAL ARTICLE
Caitlin S Lees, Hsien Seow, Kelvin K W Chan, Anastasia Gayowsky, Shaila J Merchant, Aynharan Sinnarajah
Indices of aggressive or supportive end-of-life (EOL) care are used to evaluate health services quality. Disparities according to sex were previously described, with studies showing that male sex is associated with aggressive EOL care. This is a secondary analysis of 69,983 patients who died of a GI malignancy in Ontario between 2006 and 2018. Quality indices from the last 14-30 days of life and aggregate measures for aggressive and supportive EOL care were derived from administrative data. Hospitalizations, emergency department use, intensive care unit admissions, and receipt of chemotherapy were considered indices of aggressive care, while physician house call and palliative home care were considered indices of supportive care...
February 22, 2024: Current Oncology
https://read.qxmd.com/read/38533530/are-measures-and-related-symptoms-of-cachexia-recorded-as-outcomes-in-gastrointestinal-cancer-chemotherapy-clinical-trials
#3
JOURNAL ARTICLE
Ross Valaire, Frances Garden, Valentina Razmovski-Naumovski
BACKGROUND: Cachexia is prevalent in gastrointestinal cancers and worsens patient outcomes and chemotherapy compliance. We examined to what extent registered gastrointestinal cancer chemotherapy clinical trials record measures and related symptoms of cachexia as outcomes, and whether these were associated with trial characteristics. METHODS: Four public trial registries (2012-2022) were accessed for Phase II and/or III randomized controlled pancreatic, gastric, and colorectal cancer chemotherapy trial protocols...
March 27, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38528746/analysis-of-risk-factors-of-postoperative-lower-extremity-deep-venous-thrombosis-in-patients-with-cervical-cancer
#4
JOURNAL ARTICLE
Shiyu Cheng, Han Gao, Yanli Li, Xiuting Shi, Xin Li, Tianzhuo Yang, Dan Teng, Tingzhu Meng, Jie Shi
Deep venous thrombosis (DVT) has a significant negative impact on surgical and tumor patient's safety and quality of life. There was no specific report on the incidence and risk factors of postoperative lower extremity DVT in cervical cancer patients. Analysis of the risk factors of postoperative DVT in patients with cervical cancer is of great clinical significance for prevention and treatment. We retrospectively analyzed 309 cervical cancer patients treated by the Hubei Cervical Cancer Prevention Center and used a logistic regression model to test the risk variables of postoperative lower extremity deep venous thrombosis in cervical cancer patients...
2024: Clinical and Applied Thrombosis/hemostasis
https://read.qxmd.com/read/38528610/metastasis-of-serous-ovarian-carcinoma-to-the-breast-a-case-report-and-review-of-the-literature
#5
REVIEW
Sofia Dueño, Rachel Stein, Mohsin Jamal, Gregory Lewis, Karina Hew
BACKGROUND: Breast metastasis from primary ovarian cancer is rare, with an estimated frequency of 0.07%. More than 110 cases are reported in the literature of metastatic spread of ovarian cancer to the breast and axilla. This entity usually represents aggressive late disease characterized by multi-drug chemoresistance and a poor prognosis with a median survival time of 16 months. Currently no standardized treatment protocol exists for this condition. CASE PRESENTATION: We present a case of a 59-year-old Caucasian female with recurrent high-grade serous ovarian cancer who was diagnosed with symptomatic unilateral breast metastasis while on fourth line chemotherapy with weekly paclitaxel...
March 26, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38528456/roar-a-re-optimization-based-online-adaptive-radiotherapy-of-anal-cancer-a-prospective-phase-ii-trial-protocol
#6
JOURNAL ARTICLE
Katrine Smedegaard Storm, Lina M Åström, Patrik Sibolt, Claus P Behrens, Gitte F Persson, Eva Serup-Hansen
BACKGROUND: Chemo-radiotherapy with curative intent for anal cancer has high complete remission rates, but acute treatment-related gastrointestinal (GI) toxicity is significant. Toxicity occurs due to irradiation of surrounding normal tissue. Current radiotherapy requires the addition of large planning margins to the radiation field to ensure target coverage regardless of the considerable organ motion in the pelvic region. This increases the irradiated volume and radiation dose to the surrounding normal tissue and thereby toxicity...
March 25, 2024: BMC Cancer
https://read.qxmd.com/read/38528445/investigator-choice-of-standard-therapy-versus-sequential-novel-therapy-arms-in-the-treatment-of-relapsed-follicular-lymphoma-refract-study-protocol-for-a-multi-centre-open-label-randomised-phase-ii-platform-trial
#7
JOURNAL ARTICLE
Graham McIlroy, Siân Lax, Charlotte Gaskell, Aimee Jackson, Malcolm Rhodes, Tania Seale, Sonia Fox, Lousie Hopkins, Jessica Okosun, Sally F Barrington, Ingo Ringshausen, Alan G Ramsay, Maria Calaminici, Kim Linton, Mark Bishton
BACKGROUND: Relapsed or refractory follicular lymphoma (rrFL) is an incurable disease associated with shorter remissions and survival after each line of standard therapy. Many promising novel, chemotherapy-free therapies are in development, but few are licensed as their role in current treatment pathways is poorly defined. METHODS: The REFRACT trial is an investigator-initiated, UK National Cancer Research Institute, open-label, multi-centre, randomised phase II platform trial aimed at accelerating clinical development of novel therapies by addressing evidence gaps...
March 25, 2024: BMC Cancer
https://read.qxmd.com/read/38525782/effects-on-quality-of-life-of-a-telemonitoring-platform-amongst-patients-with-cancer-equalite-a-randomized-trial-protocol
#8
JOURNAL ARTICLE
Felipe Martínez, Carla Taramasco, Manuel Espinoza, Johanna Acevedo, Carolina Goic, Bruno Nervi
Cancer, a pervasive global health challenge, necessitates chemotherapy or radiotherapy treatments for many prevalent forms. However, traditional follow-up approaches encounter limitations, exacerbated by the recent COVID-19 pandemic. Consequently, telemonitoring has emerged as a promising solution, although its clinical implementation lacks comprehensive evidence. This report depicts the methodology of a randomized trial which aims to investigate whether leveraging a smartphone app called Contigo for disease monitoring enhances self-reported quality of life among patients with various solid cancers compared to standard care...
March 15, 2024: Methods and Protocols
https://read.qxmd.com/read/38521934/efficacy-and-mechanisms-of-cannabis-oil-for-alleviating-side-effects-of-breast-cancer-chemotherapy-cbc2-protocol-for-randomized-controlled-trial
#9
JOURNAL ARTICLE
May Soe Thu, Krit Pongpirul, Mawin Vongsaisuwon, Chanida Vinayanuwattikun, Kamonwan Banchuen, Thunnicha Ondee, Sunchai Payungporn, Phanupong Phutrakool, Preecha Nootim, Pajaree Chariyavilaskul, Sarocha Cherdchom, Kulthanit Wanaratna, Nattiya Hirankarn
BACKGROUND: In a pilot study using both cannabidiol (CBD) and tetrahydrocannabinol (THC) as single agents in advanced cancer patients undergoing palliative care in Thailand, the doses were generally well tolerated, and the outcome measure of total symptom distress scores showed overall symptom benefit. The current study aims to determine the intensity of the symptoms experienced by breast cancer patients, to explore the microbiome profile, cytokines, and bacterial metabolites before and after the treatment with cannabis oil or no cannabis oil, and to study the pharmacokinetics parameters and pharmacogenetics profile of the doses...
March 23, 2024: BMC complementary medicine and therapies
https://read.qxmd.com/read/38521641/toward-a-comprehensive-supportive-care-intervention-for-older-men-with-metastatic-prostate-cancer-topcop3-a-pilot-randomized-controlled-trial-and-process-evaluation
#10
JOURNAL ARTICLE
Shabbir M H Alibhai, Martine Puts, Rana Jin, Kian Godhwani, Maryjo Antonio, Soha Abdallah, Gregory Feng, Monika K Krzyzanowska, Enrique Soto-Perez-de-Celis, Efthymios Papadopoulos, Calvin Mach, Ferozah Nasiri, Srikala S Sridhar, Rachel Glicksman, Lesley Moody, Jacqueline Bender, Hance Clarke, Andrew Matthew, Dennis McIntosh, Winston Klass, Urban Emmenegger
INTRODUCTION: Current management of metastatic prostate cancer (mPC) includes androgen receptor axis-targeted therapy (ARATs), which is associated with substantial toxicity in older adults. Geriatric assessment and management and remote symptom monitoring have been shown to reduce toxicity and improve quality of life in patients undergoing chemotherapy, but their efficacy in patients being treated with ARATs has not been explored. The purpose of this study is to examine whether these interventions, alone or in combination, can improve treatment tolerability and quality of life (QOL) for older adults with metastatic prostate cancer on ARATs...
March 22, 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/38519964/fatigue-in-children-who-have-recently-completed-treatment-for-acute-lymphoblastic-leukemia-a-longitudinal-study
#11
JOURNAL ARTICLE
S Walsh, M Mulraney, M C McCarthy, Cinzia R De Luca
BACKGROUND: This study examined fatigue in patients treated for childhood acute lymphoblastic leukemia (ALL) over a 2-year period (3- to 27-months post-treatment completion), from the perspective of children and parent caregivers, compared to a healthy comparison group. METHODS: Eighty-three patients (4-16 years at enrolment) and their parents, reported on the child's fatigue using the Pediatric Quality of Life Inventory- Multidimensional Fatigue Scale (PedsQL-MFS), at 3- 15- and 27-months post-treatment completion, and 53 healthy children and their parents reported on fatigue across the same timepoints...
March 22, 2024: Health and Quality of Life Outcomes
https://read.qxmd.com/read/38519596/the-effectiveness-of-therapeutic-artmaking-on-depression-anxiety-quality-of-life-and-psychological-distress-in-cancer-patients-on-chemotherapy-a-systematic-review-of-the-literature
#12
REVIEW
Juan Peng, Dan Cheng
OBJECTIVES: The purpose of this study was to evaluate the evidence of art therapy on depression, anxiety, quality of life, and mental distress in cancer patients undergoing chemotherapy. METHODS: A systematic literature search was conducted. A systematic search of online electronic databases including, PubMed/MEDLINE, Scopus Web of Science, PsycINFO, and EMBASE was performed using keywords extracted from Medical Subject Headings such as "Art Therapy," and "Neoplasms," "Cancer," and "Chemotherapy" from the earliest to January 11, 2023...
March 22, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38519388/female-fertility-cryopreservation-outcomes-in-childhood-cancer-a-systematic-review
#13
REVIEW
Srinithya R Gillipelli, Luca Pio, Paul D Losty, Abdelhafeez H Abdelhafeez
BACKGROUND AND AIMS: As survival rates in childhood cancer progress significantly, health outcomes in adulthood are pivotal to quality of life (QoL). Female patients undergoing chemotherapy and radiation for childhood cancer may experience adverse effects such as gonadotoxicity-related ovarian insufficiency. Ovarian tissue cryopreservation (OTC) is well studied in adults, but has only recently started to be explored in an effort to preserve fertility in young patients with childhood cancer...
March 1, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38518541/nutritional-status-of-women-with-non-metastatic-breast-cancer-receiving-outpatient-chemotherapy
#14
JOURNAL ARTICLE
Júlia Anhoque Cavalcanti Marcarini, Wesley Rocha Grippa, Luiz Claudio Barreto Silva Neto, Olívia Perim Galvão Podestá, Andressa Bolsoni-Lopes, Karolini Zuqui Nunes, Luís Carlos Lopes-Júnior
OBJECTIVES: The aim of this study was to evaluate and compare the nutritional status of women with stage I to III breast cancer in the first and third cycles of outpatient chemotherapy and to identify factors associated with it. METHODS: The prospective longitudinal study was conducted at a Reference Hospital for Cancer Care in Brazil and included women aged ≥18 y diagnosed with stage I to III breast cancer receiving outpatient chemotherapy. Assessments were performed during the 1st and 3rd cycles of chemotherapy, including anthropometric measurements, sociodemographic data, clinical information, and quality of life...
February 29, 2024: Nutrition
https://read.qxmd.com/read/38518107/anticancer-drugs-related-hypogonadism-in-male-patients-with-advanced-cancers-on-active-treatment-a-systematic-review
#15
JOURNAL ARTICLE
Giacomo Massa, Luca Zambelli, Ernesto Zecca, Morena Shkodra, Gabriele Tinè, Augusto Caraceni
BACKGROUND: In male patients with cancer treated with antineoplastic drug, hypogonadism is a neglected cause of diminished quality of life. This condition may be cancer related as well as toxicity related. The role of antineoplastic drug in causing hypogonadism is poorly understood. The aim of this systematic review was to establish the prevalence, nature (primary/secondary), and impact of hypogonadism on quality of life in male patients with cancer on antineoplastic therapy. METHODS: The search strategy used PubMed, Embase, and Cochrane databases to select articles in English language that described hypogonadism in male patients with cancer...
March 22, 2024: Oncologist
https://read.qxmd.com/read/38517848/chemosensory-changes-during-chemotherapy
#16
JOURNAL ARTICLE
Mona Abed El-Rahman Mohamed, Noha Mohammed Ibrahim Ibrahim, Hanan Hassan Elezaby, Mariam Sabry Shehab
BACKGROUND: Chemosensory changes that occur during chemotherapy can significantly impact food enjoyment, quality of life and recovery. AIM: To investigate chemosensory changes reported by oncology patients during chemotherapy. METHODS: A mixed-method cross-sectional study design was used to explore 100 cancer patients' experiences of chemosensory changes during chemotherapy. All patients completed a questionnaire assessing their taste and smell preferences...
March 2, 2024: International Journal of Palliative Nursing
https://read.qxmd.com/read/38517596/treatment-options-for-distal-rectal-cancer-in-the-era-of-organ-preservation
#17
REVIEW
Chen Wang, Xiaoliang Liu, Weiping Wang, Zheng Miao, Xiaoyan Li, Dingchao Liu, Ke Hu
The introduction of total mesorectal excision into the radical surgery of rectal cancer has significantly improved the oncological outcome with longer survival and lower local recurrence. Traditional treatment modalities of distal rectal cancer, relying on radical surgery, while effective, take their own set of risks, including surgical complications, potential damage to the anus, and surrounding structure owing to the pursuit of thorough resection. The progress of operating methods as well as the integration of systemic therapies and radiotherapy into the peri-operative period, particularly the exciting clinical complete response of patients after neoadjuvant treatment, have paved the way for organ preservation strategy...
March 22, 2024: Current Treatment Options in Oncology
https://read.qxmd.com/read/38517148/unmet-needs-in-the-process-of-chemotherapy-provision-in-pancreatic-cancer-patients-from-the-healthcare-provider-perspective-a-phenomenological-study-in-greece
#18
JOURNAL ARTICLE
Stella Ploukou, Εleni Papakosta-Gaki, Efharis Panagopoulou, Alexios Benos, Emmanoui Smyrnakis
INTRODUCTION: Pancreatic cancer is the fourth leading cause of cancer death overall, with 1.5 years life expectancy and minimal therapeutic progress in the last decades. Despite the burden it causes, there is little research on the needs of this specific population. This study aimed to explore healthcare professionals' views on providing care and patients' unsatisfied needs. METHODS: This qualitative descriptive study was carried out at a cancer hospital in Northern Greece...
June 2024: Zdravstveno Varstvo
https://read.qxmd.com/read/38515579/risk-factors-of-paclitaxel-induced-peripheral-neuropathy-in-patients-with-breast-cancer-a-prospective-cohort-study
#19
JOURNAL ARTICLE
Sun Lixian, Yu Xiaoqian, Guo Luyan, Zhou Lizhi, Du Rui, Yao Hongyue, Zhao Caijie, Yuan Fenghui
OBJECTIVE: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and severe adverse reaction in taxane-based chemotherapy. This study aimed to analyze the risk factors of peripheral neuropathy in patients with breast cancer receiving paclitaxel chemotherapy to provide a reference for the early prevention of CIPN. METHODS: We included 350 patients with breast cancer who received chemotherapy for the first time at the Tangshan People's Hospital between August 2022 and June 2023 and were followed for at least 3 months after the end of chemotherapy...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38513683/mri-guided-stereotactic-ablative-body-radiotherapy-versus-ct-guided-percutaneous-irreversible-electroporation-for-locally-advanced-pancreatic-cancer-crossfire-a-single-centre-open-label-randomised-phase-2-trial
#20
JOURNAL ARTICLE
Florentine E F Timmer, Bart Geboers, Alette H Ruarus, Laurien G P H Vroomen, Evelien A C Schouten, Susan van der Lei, Danielle J W Vos, Madelon Dijkstra, Hannah H Schulz, Joyce Bakker, Bente A T van den Bemd, Petrousjka M van den Tol, Robbert S Puijk, Birgit I Lissenberg-Witte, Tanja D de Gruijl, Jan J J de Vries, Frank J Lagerwaard, Hester J Scheffer, Anna M E Bruynzeel, Martijn R Meijerink
BACKGROUND: Pancreatic ductal adenocarcinoma is an aggressive disease with a dismal prognosis. Stage III locally advanced pancreatic cancer is considered unresectable and current palliative chemotherapy regimens only modestly improve survival. Guidelines suggest chemoradiation or stereotactic ablative body radiotherapy (SABR) could be beneficial in certain circumstances. Other local treatments such as irreversible electroporation could enhance patient outcomes by extending survival while preserving quality of life...
March 18, 2024: Lancet. Gastroenterology & Hepatology
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