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chemotherapy versus palliative care

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https://www.readbyqxmd.com/read/29216749/impact-of-palliative-chemotherapy-and-travel-distance-on-hospice-referral-in-patients-with-stage-iv-pancreatic-cancer-a-retrospective-analysis-within-a-veterans-administration-medical-center
#1
Jennifer M Duff, Ryan M Thomas
BACKGROUND: Metastatic pancreatic ductal adenocarcinoma (mPDAC) has a poor prognosis despite chemotherapy advancements. Although hospice utilization has increased, timing of referral is not always optimal. AIM: To investigate whether palliative chemotherapy and travel distance to the treatment center impact hospice referral patterns in veterans of the US military in order to identify potential areas for improving referral timing. DESIGN: Demographic and clinical data were collected retrospectively according to the timing of hospice referral...
January 1, 2017: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29182797/palliative-chemotherapy-and-targeted-therapies-for-esophageal-and-gastroesophageal-junction-cancer
#2
REVIEW
Vincent T Janmaat, Ewout W Steyerberg, Ate van der Gaast, Ron Hj Mathijssen, Marco J Bruno, Maikel P Peppelenbosch, Ernst J Kuipers, Manon Cw Spaander
BACKGROUND: Almost half of people with esophageal or gastroesophageal junction cancer have metastatic disease at the time of diagnosis. Chemotherapy and targeted therapies are increasingly used with a palliative intent to control tumor growth, improve quality of life, and prolong survival. To date, and with the exception of ramucirumab, evidence for the efficacy of palliative treatments for esophageal and gastroesophageal cancer is lacking. OBJECTIVES: To assess the effects of cytostatic or targeted therapy for treating esophageal or gastroesophageal junction cancer with palliative intent...
November 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29101205/outcome-after-relapse-of-myelodysplastic-syndrome-and-secondary-acute-myeloid-leukemia-after-allogeneic-stem-cell-transplantation-a-retrospective-registry-analysis-on-698-patients-by-the-chronic-malignancies-working-party-of-european-society-of-blood-and-marrow
#3
Christoph Schmid, Liesbeth C de Wreede, Anja van Biezen, Jürgen Finke, Gerhard Ehninger, Arnold Ganser, Liisa Volin, Dietger Niederwieser, Dietrich Beelen, Paolo Alessandrino, Lothar Kanz, Michael Schleuning, Jakob Passweg, Hendrik Veelken, Johan Maertens, Jan J Cornelissen, Didier Blaise, Martin Gramatzki, Noel Milpied, Ibrahim Yakub-Agha, Ghulam Mufti, Montserrat Rovira, Renate Arnold, Theo De Witte, Marie Robin, Nikolaus Kröger
No standard exists for the treatment of myelodysplastic syndrome relapsing after allogeneic stem cell transplantation. We performed a retrospective registry analysis of outcome and risk factors in 698 patients, treated with different strategies. Median overall survival from relapse was 4.7 months (4.1-5.3), 2-year survival was 17.7% (14.8-21.2%). Shorter remission after transplantation (p<0.001), advanced disease (p=0.001), older age (p=0.007), unrelated donor (p=0.008) and acute Graft-versus-Host disease before relapse (p<0...
November 3, 2017: Haematologica
https://www.readbyqxmd.com/read/28982209/cost-effective-imaging-for-resectability-of-liver-lesions-in-colorectal-cancer-an-economic-decision-model
#4
Sopany Saing, Phil Haywood, Joanna K Duncan, Ning Ma, Alun L Cameron, Stephen Goodall
BACKGROUND: This study aimed to determine the cost-effectiveness of contrast-enhanced magnetic resonance imaging (CE-MRI) compared with multiphase CE computed tomography (CE-CT) scan to characterize suspected liver lesions in patients with known colorectal carcinoma. METHODS: A decision analytic model linking diagnostic accuracy to health outcomes in patients with colorectal carcinoma was constructed. The model assumed that CE-MRI has superior sensitivity and equivalent specificity to CE-CT, and patients with a colorectal liver metastasis could be eligible for curative surgery or chemotherapy and palliation...
October 5, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28838033/chemotherapy-versus-best-supportive-care-in-advanced-biliary-tract-carcinoma-a-multi-institutional-propensity-score-matching-analysis
#5
Jun Ho Ji, Young Saing Kim, Inkeun Park, Soon Il Lee, Rock Bum Kim, Joon Oh Park, Sung Yong Oh, In Gyu Hwang, Joung-Soon Jang, Haa-Na Song, Jung-Hun Kang
Purpose: Although chemotherapy is recommended by various guidelines for advanced biliary tract cancer (BTC), the evidence supporting its use over best supportive care (BSC) is limited. The aim of this study was to investigate the survival benefit of chemotherapy over that of BSC in advanced BTC patients. Materials and Methods: Advanced BTC patients with a good performance status (ECOG 0-2) were eligible for the study. Data were retrospectively collected from 4 tertiary cancer centers and analyzed using propensity score matching (PSM)...
August 23, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28674913/primary-care-versus-oncology-based-surveillance-following-adjuvant-chemotherapy-in-resected-pancreatic-cancer
#6
Haider H Samawi, Yaling Yin, Howard J Lim, Winson Y Cheung
INTRODUCTION: High level evidence to guide surveillance following curative intent treatment for pancreatic cancer is lacking and this has likely resulted in wide variations in practice. We aim to describe patterns of surveillance and evaluate their impact on outcomes. METHODS: A total of 147 adult patients who received at least one cycle of adjuvant gemcitabine or 5-fluorouracil-based chemotherapy at any one of five British Columbia Cancer Agency centers between 2001 and 2015 were included...
July 4, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28601379/a-systematic-review-of-patient-values-preferences-and-expectations-for-the-treatment-of-recurrent-ovarian-cancer
#7
REVIEW
(no author information available yet)
BACKGROUND AND OBJECTIVES: It is our belief that patient preference should play a significant role in disease management of recurrent ovarian cancer. Since cure is seldom an endpoint in this circumstance, patients' attitudes toward the risks and benefits of chemotherapy versus palliation are relevant. METHODS: Medline, Embase, CINAHL and PsycINFO from were searched from January 1, 2000 to December 13, 2016 for studies of values, preferences or expectations of women with platinum-sensitive recurrent or refractory ovarian cancer...
August 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28587264/being-in-the-chemotherapy-suite-versus-being-in-the-oncology-ward-an-analytical-view-of-two-hospital-sites-occupied-by-people-experiencing-cancer
#8
Catherine Hughes, Kate van Heugten, Sally Keeling, Francisc Szekely
How do people with cancer occupy places within the health system during their journey through palliative care? The answer to this question was explored by the authors as part of a wider ethnographic study of eight people's journeys from referral to palliative care services to the end of life. This article reports on findings that have emerged from ongoing analysis that has been completed in the years proceeding data collection. An ethnographic research design was used to collect data about the participants and their family members over a three-year period...
June 5, 2017: Cancers
https://www.readbyqxmd.com/read/28501134/factors-associated-with-palliative-care-use-in-patients-undergoing-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#9
Rachel S Morris, Faiz Gani, Abdulrahman Y Hammad, Wendy Peltier, T Clark Gamblin, Kiran K Turaga, Fabian M Johnston
BACKGROUND: Peritoneal carcinomatosis represents widespread metastatic disease throughout the abdomen and/or pelvis. Cytoreductive surgery/hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) improves the overall survival compared to standard therapy alone. The role palliative care (PC) plays however, remains poorly studied among these patients. METHODS: Patients who had previously undergone HIPEC and who underwent an inpatient admission from 7/1/2013 to 6/30/2014 were identified to determine which patients were referred for inpatient or outpatient palliative consultation...
May 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28156621/comparison-of-two-indwelling-pleural-catheter-types-for-malignant-pleural-effusions
#10
Sushilkumar Satish Gupta, Abhinav Binod Chandra
205 Background: Indwelling pleural catheter (IPC) placement is an alternative to chemical pleurodesis for malignant pleural effusion (MPE), a complication of advanced cancer. In 1997 an IPC was approved which uses vacuum bottles (VB) for drainage (PleurX, Becton, Dickinson and Company, Franklin Lakes, NJ), and later another IPC system, which employs a manually operated vacuum pump (VP) for drainage (Aspira, Bard Access Systems, Salt Lake City, UT). Most studies comparing IPC versus chemical pleurodesis used the VB IPC...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156492/food-as-medicine-a-randomized-controlled-trial-rct-of-home-delivered-medically-tailored-meals-hdmtm-on-quality-of-life-qol-in-metastatic-lung-and-non-colorectal-gi-cancer-patients
#11
Raymond Mailhot Vega, Lisa Zullig, Alissa Wassung, Dorella Walters, Noah Berland, Kevin Lee Du, Jiyoung Ahn, Cynthia G Leichman, Deirdre Jill Cohen, Ping Gu, Abraham Chachoua, Lawrence P Leichman, Karen Pearl, Peter B Schiff
155 Background: Malnutrition incidence in cancer approaches 85%, disproportionately burdening those with lung, GI, and advanced stage cancers. Malnourished patients have impaired chemotherapy response, shorter survival, longer hospital stays, and decreased QoL. Home delivered meals are nutritional interventions that improve patient well-being, nutrition, and lower healthcare costs in the elderly but have not been studied as an intervention in cancer patients. HDMTM are nutritionist prescribed home delivered meals tailored to patient's symptoms, co-morbidities, and health needs...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27821313/systematic-versus-on-demand-early-palliative-care-a-randomised-clinical-trial-assessing-quality-of-care-and-treatment-aggressiveness-near-the-end-of-life
#12
RANDOMIZED CONTROLLED TRIAL
Marco Maltoni, Emanuela Scarpi, Monia Dall'Agata, Stefania Schiavon, Claudia Biasini, Carla Codecà, Chiara Maria Broglia, Elisabetta Sansoni, Roberto Bortolussi, Ferdinando Garetto, Luisa Fioretto, Maria Teresa Cattaneo, Alice Giacobino, Massimo Luzzani, Giovanna Luchena, Sara Alquati, Silvia Quadrini, Vittorina Zagonel, Luigi Cavanna, Daris Ferrari, Paolo Pedrazzoli, Giovanni Luca Frassineti, Antonella Galiano, Andrea Casadei Gardini, Manlio Monti, Oriana Nanni
AIM: Early palliative care (EPC) in oncology has shown sparse evidence of a positive impact on patient outcomes, quality of care outcomes and costs. PATIENTS AND METHODS: Data for this secondary analysis were taken from a trial of 207 outpatients with metastatic pancreatic cancer randomly assigned to receive standard cancer care plus on-demand EPC (standard arm) or standard cancer care plus systematic EPC (interventional arm). After 20 months' follow-up, 149 (80%) had died...
December 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27785685/a-cost-effectiveness-analysis-of-gemcitabine-plus-cisplatin-versus-gemcitabine-alone-for-treatment-of-advanced-biliary-tract-cancer-in-japan
#13
Ikuto Tsukiyama, Masayuki Ejiri, Yoshihiro Yamamoto, Haruhisa Nakao, Masashi Yoneda, Katsuhiko Matsuura, Ichiro Arakawa, Hiroko Saito, Tadao Inoue
OBJECTIVES: This study assessed the cost-effectiveness of combination treatment with gemcitabine and cisplatin compared to treatment with gemcitabine alone for advanced biliary tract cancer (BTC) in Japan. METHODS: A monthly transmitted Markov model of three states was constructed based on the Japan BT-22 trial. Transition probabilities among the health states were derived from a trial conducted in Japan and converted to appropriate parameters for our model. The associated cost components, obtained from a receipt-based survey undertaken at the Aichi Medical University Hospital, were those related to inpatient care, outpatient care, and treatment for BTC...
December 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/27683640/incidence-and-risk-factors-of-hypomagnesemia-in-head-and-neck-cancer-patients-treated-with-cetuximab
#14
Tomohiro Enokida, Shinya Suzuki, Tetsuro Wakasugi, Tomoko Yamazaki, Susumu Okano, Makoto Tahara
BACKGROUND: Hypomagnesemia is a common adverse event during cetuximab (Cmab) treatment. However, few reports have investigated the incidence and risk factors of hypomagnesemia in head and neck cancer patients treated with Cmab. METHODS: We retrospectively reviewed 131 head and neck cancer patients who received Cmab-containing therapy. Main eligibility criteria were ≥3 Cmab administrations, no prior EGFR-directed therapy, and no prophylactic Mg supplementation...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27670894/population-based-patterns-and-factors-associated-with-underuse-of-palliative-systemic-therapy-in-elderly-patients-with-metastatic-colon-cancer
#15
Matthew Chan, Kiara Hugh-Yeun, Gillian Gresham, Caroline H Speers, Hagen F Kennecke, Winson Y Cheung
BACKGROUND: We compared the patterns and factors associated with chemotherapy and bevacizumab use in elderly versus young patients with metastatic colon cancer (mCC) and determined the effect of systemic therapy on overall survival (OS) according to age. MATERIALS AND METHODS: Patients diagnosed with mCC from 2009 to 2010 in British Columbia, Canada were reviewed and categorized as elderly patients (age ≥ 70 years) and young patients (age < 70 years). Cox regression models adjusted for age and confounders were used to determine the effect of systemic therapy on OS...
August 30, 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/27177600/changing-trends-in-diagnosis-staging-treatment-and-survival-in-lung-cancer-comparison-of-three-consecutive-cohorts-in-an-australian-lung-cancer-centre
#16
COMPARATIVE STUDY
E J Denton, D Hart, Z Wainer, G Wright, P A Russell, M Conron
BACKGROUND: Lung cancer accounts for significant morbidity and mortality worldwide. The effect of recent changes in demographics and management on outcomes in Australia has not been clearly defined. AIMS: To compare three consecutive lung cancer cohorts to evaluate emergent differences in diagnosis, management and mortality. METHODS: For comparative analysis, 2119 lung cancer patients were divided into three successive cohorts. Current death data were sought from the Victorian Cancer Registry...
August 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/26639897/routine-assessment-of-performance-status-during-palliative-chemotherapy-when-approaching-end-of-life
#17
Ulla Näppä, Olav Lindqvist, Birgit H Rasmussen, Bertil Axelsson
PURPOSE: Palliative chemotherapy treatment (PCT) offered late in the cancer disease trajectory may be problematic. It is not easy to accurately calculate whether the potential benefits will outweigh the side-effects. This study investigates whether routine use of the Performance Status in Palliative Chemotherapy questionnaire (PSPC) affects the proportions of patients receiving PCT during the last month of life, care utilization, and documentation routines. A secondary aim was to gather registered nurses' experiences of the PSPC in routine use...
April 2016: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/26536194/the-influence-of-the-evolution-of-first-line-chemotherapy-on-steadily-improving-survival-in-advanced-non-small-cell-lung-cancer-clinical-trials
#18
Krista L Noonan, Cheryl Ho, Janessa Laskin, Nevin Murray
Over the past three decades, survival in advanced non-small-cell lung cancer (NSCLC) clinical trials has doubled with an increase in 1-year survival from 25% to 50 to 55%. This has been mainly attributed to improvements in systemic therapy. Although modern first-line chemotherapy regimens have more favorable toxicity profiles, a statistically significant improvement in overall survival has not been demonstrated in existing meta-analyses of second-generation versus third-generation combinations. Moreover, pivotal trials demonstrating statistically significant survival superiority of third-generation regimens are consistently not reproducible even for nonsquamous populations using pemetrexed-platinum combinations...
November 2015: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/26157282/indian-council-of-medical-research-consensus-document-for-the-management-of-gall-bladder-cancer
#19
Hari Shankar Shukla, Bhawna Sirohi, Anu Behari, Atul Sharma, Jahar Majumdar, Manomoy Ganguly, Mallika Tewari, Sandeep Kumar, Sunil Saini, Peush Sahni, Tomcha Singh, Vinay Kumar Kapoor, V Sucharita, Tanvir Kaur, Deepak Kumar Shukla, Goura Kishor Rath
The document is based on consensus among the experts and best available evidence pertaining to Indian population and is meant for practice in India.All postcholecystectomy gallbladder specimens should be opened and examined carefully by the operating surgeon and be sent for histopathological examination.All "incidental" gall bladder cancers (GBCs) picked up on histopathological examination should have an expert opinion.Evaluation of a patient with early GBC should include essential tests: A computed tomography (CT) scan (multi-detector or helical) of the abdomen and pelvis for staging with a CT chest or chest X-ray, and complete blood counts, renal and liver function tests...
April 2015: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/25926135/health-care-utilization-and-end-of-life-care-for-older-patients-with-acute-myeloid-leukemia
#20
Areej R El-Jawahri, Gregory A Abel, David P Steensma, Thomas W LeBlanc, Amir T Fathi, Timothy A Graubert, Daniel J DeAngelo, Martha Wadleigh, Karen K Ballen, Julia E Foster, Eyal C Attar, Philip C Amrein, Andrew M Brunner, Richard M Stone, Jennifer S Temel
BACKGROUND: Health care utilization in older adults (age ≥60 years) with acute myeloid leukemia (AML) has not been well studied. METHODS: We conducted a retrospective analysis of 330 consecutive older patients who were diagnosed with AML between May 1, 2005 and December 23, 2011, at 2 hospitals in Boston to examine their health care utilization and end-of-life care. Using multivariable logistic and linear regression models adjusting for covariates, we also compared health care utilization between patients who received intensive induction chemotherapy (n = 197; cytarabine/ anthracycline combination) versus nonintensive chemotherapy (n = 133; single-agent therapy)...
August 15, 2015: Cancer
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