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Calcium liver

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https://www.readbyqxmd.com/read/28229818/relationship-between-calcium-channel-blockers-and-skin-fibrosis-in-patients-with-systemic-sclerosis
#1
Guowei Li, Jonathan D Adachi, Ji Cheng, Lehana Thabane, Marie Hudson, Marvin J Fritzler, Steven Lorenzi, Murray Baron, Maggie Larché
OBJECTIVES: Recent experimental evidence suggests that calcium channel blockers (CCBs) may have anti-fibrotic effects on liver and pulmonary fibrosis. We aimed to investigate whether use of CCBs was associated with the skin fibrosis in patients with systemic sclerosis (SSc). METHODS: Based on the 5-year follow-up data from the Canadian Scleroderma Research Group registry, we used the generalised estimating equations (GEE) model to assess the relationship between use of CCBs and the primary outcome of skin fibrosis measured by the modified Rodnan skin score (mRSS)...
January 31, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28223025/transcriptional-regulation-of-human-paraoxonase-1-by-nuclear-receptors
#2
REVIEW
N Ponce-Ruiz, F E Murillo-González, A E Rojas-García, Mike Mackness, Y Y Bernal-Hernández, B S Barrón-Vivanco, C A González-Arias, I M Medina-Díaz
Paraoxonase 1 (PON1) is a calcium-dependent esterase synthesized primarily in the liver and secreted into the plasma, where it is associates with high density lipoproteins (HDL). PON1 acts as antioxidant preventing low-density lipoprotein (LDL) oxidation which is believed to be critical in the initiation and progression of atherosclerosis. Additionally, PON1 hydrolyzes and detoxifies some toxic metabolites of organophosphorus compounds (OPs). Thus, PON1 activity and expression levels are important for determining susceptibility to OPs intoxication and risk of diseases related to inflammation and oxidative stress...
February 18, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28220742/calcific-uraemic-arteriolopathy-calciphylaxis-in-patients-on-renal-replacement-therapy
#3
S Sebastian, H F Jordaan, J W Schneider, M R Moosa, M R Davids
BACKGROUND: Calcific uraemic arteriolopathy (calciphylaxis) is an unusual and potentially fatal condition characterised by small-vessel calcification and ischaemic skin necrosis. It mainly affects patients with end-stage renal disease (ESRD) on haemodialysis, but may rarely occur in the absence of ESRD in conditions such as primary hyperparathyroidism, malignancy, alcoholic liver disease and connective tissue disease. METHODS: We reviewed the records of all patients diagnosed with calciphylaxis while on renal replacement therapy at Tygerberg Hospital, Cape Town, South Africa, between 1990 and 2014, to describe its presentation, course and final outcome...
January 30, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28220621/a-low-prevalence-of-non-alcoholic-fatty-liver-disease-in-patients-with-type-1-diabetes-is-associated-to-decreased-subclinical-cardiovascular-disease
#4
Enric Serra-Planas, Eva Aguilera, Laura Castro, Raúl Rodríguez, Isabel Salinas, Anna Lucas, Clara Joaquín, Rocio Puig, Dídac Mauricio, Manel Puig-Domingo
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has been proposed as an independent cardiovascular risk factor. This study evaluated the prevalence of NAFLD in a cohort of Type 1 Diabetic (T1D) patients and its potential relationship with subclinical cardiovascular disease (CVD). METHODS: Cross-sectional study in which 100 T1D patients (39.4 ± 7.8 years, 54% male, all Caucasian, disease duration 21.7 ± 8.6 years, HbA1c 8.1 ± 1.0 % (64.2 ± 7...
February 20, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28220501/chronic-alcohol-feeding-potentiates-hormone-induced-calcium-signalling-in-hepatocytes
#5
Paula J Bartlett, Anil Noronha Antony, Amit Agarwal, Mauricette Hilly, Victoria L Prince, Laurent Combettes, Jan B Hoek, Lawrence D Gaspers
"Adaptive" responses of the liver to chronic alcohol consumption may underlie the development of cell and tissue injury. Alcohol administration can perturb multiple signalling pathways including phosphoinositide-dependent cytosolic calcium ([Ca(2+) ]i ) increases, which can adversely affect mitochondrial Ca(2+) levels, reactive oxygen species production and energy metabolism. Our data indicate that chronic alcohol feeding induces a leftward shift in the dose-response for Ca(2+) -mobilizing hormones resulting in more sustained and prolonged [Ca(2+) ]i increases in both cultured hepatocytes and hepatocytes within the intact perfused liver...
February 20, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28220370/the-effect-of-candesartan-on-pentraxin-3-plasma-levels-as-marker-of-endothelial-dysfunction-in-patients-with-essential-arterial-hypertension
#6
V Buda, M Andor, C Cristescu, M Voicu, F Cochera, P Tuduce, L Petrescu, M C Tomescu
BACKGROUND: In the last decades, the studies performed on the field of endothelial dysfunction confirmed the fact that the starting point of this pathology is the inflammation. Several inflammatory biomarkers had been discovered and studied, ones showing systemic inflammation, and others being more specific biomarkers and showing the local inflammation. Pentraxin-3 (PTX3) is a new inflammatory biomarker, from the same family as high-selectivity C-reactive protein (hs-CRP), but it is a more specific biomarker, due to its local production: the endothelial cells and not the liver like in the case of hs-CRP...
February 21, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28219837/chronic-maternal-calcium-and-25-hydroxyvitamin-d-deficiency-in-wistar-rats-programs-abnormal-hepatic-gene-expression-leading-to-hepatic-steatosis-in-female-offspring
#7
Sona S Sharma, Nivedita M Jangale, Abhay M Harsulkar, Medha K Gokhale, Bimba N Joshi
Importance of calcium and vitamin D deficiency is well established in adult dyslipidemia. We hypothesized that maternal calcium and vitamin D deficiency could alter offspring's lipid metabolism. Our objective was to investigate the effect of maternal dietary calcium and vitamin D deficiency on lipid metabolism and liver function of the F1 generation offspring. intergenerational calcium-deficient (CaD) and vitamin D-deficient (VDD) models were developed by mating normal male rats with deficient females and continuing maternal-deficient diets through pregnancy and lactation...
February 8, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28216891/effects-of-potassium-sulfate-k2so4-on-the-element-contents-polyphenol-content-antioxidant-and-antimicrobial-activities-of-milk-thistle-silybum-marianum
#8
Gulsum Yaldiz
BACKGROUND: Silybum marianum L. (Milk thistle) is native to the Mediterranean basin and is now widespread throughout the world. It's sprout is used as a herbal medicine for the treatment of liver disease for centuries. The seeds of milk thistle contain silymarin, an isomeric mixture of flavonolignans [silybin, silychristin, and silydianin]. Silymarin acts as a strong anti-hepatotoxic. OBJECTIVES: The objective of this study was to evaluate the influences of potassium sulfate [K2SO4] fertilizer doses on polyphenol content, some nutrient elements, antioxidant and antimicrobial activities of milk thistle at experimental fields of Ordu University in Turkey...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28214296/abnormally-high-and-heterogeneous-bone-matrix-mineralization-after-childhood-solid-organ-transplantation-a-complex-pathology-of-low-bone-turnover-and-local-defects-in-mineralization
#9
Nadja Fratzl-Zelman, Helena Valta, Renata C Pereira, Barbara M Misof, Paul Roschger, Hannu Jalanko, Kathrine Wesseling-Perry, Klaus Klaushofer, Outi Mäkitie
Chronic renal, liver and heart failure in children associates with multiple skeletal complications. Increased fracture incidence often persists after transplantation and could be related to alterations in bone material properties. In the present cohort study we evaluated bone mineralization density distribution (BMDD) by quantitative backscattered electron imaging (qBEI) in 23 pediatric solid organ allograft recipients with suspected osteoporosis. We measured BMDD in the entire cross-sectional area of transiliac bone biopsies obtained from kidney (n = 9), liver (n = 9) and heart (n = 5) transplant recipients (aged 7...
February 18, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28213291/hepatoprotective-effect-of-2-o-galloylhyperin-against-oxidative-stress-induced-liver-damage-through-induction-of-nrf2-are-mediated-antioxidant-pathway
#10
Peng Wang, Yi-Meng Gao, Xing Sun, Na Guo, Ji Li, Wei Wang, Li-Ping Yao, Yu-Jie Fu
2'-O-galloylhyperin (2'-O-GH), an active compound isolated from Pyrola calliantha, possesses remarkable antioxidant activity. The aims of this study were to investigate the hepatoprotective effect of 2'-O-GH against oxidative stress and elucidate the underlying mechanistic signaling pathways in HepG2 cells as well as in an animal model. Results showed that 2'-O-GH significantly inhibited hydrogen peroxide (H2O2)-induced HepG2 cell death in a dose dependent manner. The mitogen-activated protein kinase activation, ROS production, mitochondrial membrane potential, intracellular calcium level and subsequent apoptotic protein activation in H2O2-stimulated HepG2 cells were remarkably inhibited by 2'-O-GH...
February 16, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28194470/effect-of-vanadium-on-calcium-homeostasis-osteopontin-mrna-expression-and-bone-microarchitecture-in-diabetic-rats
#11
Cristina Sanchez-Gonzalez, Laura Moreno, Carlos Lopez-Chaves, Elena Nebot, Peter Pietschmann, Alba Rodriguez-Nogales, Julio Galvez, María Montes-Bayon, Alfredo Sanz-Medel, Juan Llopis
The aim of this study was to examine whether alterations caused by diabetes in calcium homeostasis, expression of osteopontin and the microarchitecture of bone are corrected by exposure to vanadium. Four study groups were examined over a period of five weeks: control (C), diabetic (DM), diabetic treated with 1 mg V per d (DMV), and diabetic treated with 3 mg V per d (DMVH). Vanadium was supplied in drinking water as bis(maltolato)oxovanadium(iv). Calcium was measured in the food, faeces, urine, serum, kidneys, liver, muscles, and femur...
February 14, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28188512/hepatic-abscess-in-the-spiegel-lobe-caused-by-foreign-body-penetration-report-of-a-case-report
#12
Yuki Fujiwara, Hiroaki Shiba, Yukio Nakabayashi, Masahiko Otsuka, Katsuhiko Yanaga
A 69-year-old male patient visited our hospital because of a continuous low-grade fever and right back pain since 2 weeks. Enhanced computed tomography (CT) of his abdomen revealed a mass with ring enhancement (35 × 30 mm) in the Spiegel lobe as well as a needle-like foreign body. Because conservative treatment by fasting and administration of antibiotics was unsuccessful, the patient underwent emergency laparotomy for removal of the foreign body and drainage of the liver abscess. The patient made a satisfactory postoperative recovery without complications and was discharged on the eighth postoperative day...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28188435/marked-increase-in-urinary-excretion-of-apolipoproteins-in-children-with-nephrolithiasis-associated-with-hypercalciuria
#13
Larisa Kovacevic, Hong Lu, Joseph A Caruso, Tuhina Govil-Dalela, Ronald Thomas, Yegappan Lakshmanan
BACKGROUND: Using a proteomic approach, we aimed to identify and compare the urinary excretion of proteins involved in lipid transport and metabolism in children with kidney stones and hypercalciuria (CAL), hypocitraturia (CIT), and normal metabolic work-up (NM), and in healthy controls (HCs). Additionally, we aimed to confirm these results using ELISA, and to examine the relationship between the urinary excretion of selected proteins with demographic, dietary, blood, and urinary parameters...
February 10, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28186986/common-cytotoxic-chemotherapeutics-induce-epithelial-mesenchymal-transition-emt-downstream-of-er-stress
#14
Parag P Shah, Tess V Dupre, Leah J Siskind, Levi J Beverly
Endoplasmic reticulum (ER) in eukaryotes is a main organelle involved in a wide variety of functions including calcium storage, lipid biosynthesis, protein folding and protein transport. Disruption of ER homeostasis leads to ER stress and activation of the unfolded protein response (UPR). We and others have previously found that ER stress induces EMT in different cellular systems. Induction of ER stress with chemical modulators of ER homeostasis was sufficient to activate an EMT-like state in all cellular systems tested...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28178714/liver-directed-embolization-for-the-long-term-control-of-hypercalcemia-of-malignancy-in-metastatic-breast-cancer
#15
Sowmya Nanjappa, Carlos A Pla-Fernandez, Susmitha Apuri, Loretta Loftus, Bela Kis
Hypercalcemia of malignancy is a common complication of certain types of cancers. No standard therapies exist for the treatment of hypercalcemia secondary to paraneoplastic syndromes that result in the long-term control of serum calcium levels. We report a case of metastatic breast cancer with parathyroid hormone-related protein associated with hypercalcemia of malignancy that was treated with transarterial embolization of the hepatic metastatic lesions.
January 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28176238/vitamin-d-status-in-patients-with-cirrhosis-of-the-liver-and-their-relatives-a-case-control-study-from-north-india
#16
Ravikant Kumar, Pavan Kumar, Kandarp Nath Saxena, Manjul Mishra, Vivek Kumar Mishra, Anju Kumari, Manisha Dwivedi, Sri Prakash Misra
BACKGROUND AND AIM: Liver diseases interfere with the production of the metabolites of vitamin D required for activation, thus resulting in abnormal calcium and bone metabolism. Previous studies show inconsistent results of vitamin D level in non-cholestatic liver diseases. Our aim was to determine the prevalence of vitamin D insufficiency in cirrhosis as compared to apparently normal relatives and its relationship with etiology and severity. METHODS: One hundred and sixty cirrhotic patients attending the Department of Gastroenterology and Hepatology, M L N Medical College, Allahabad, were enrolled, and 25-hydroxy vitamin D [25(OH)D] and calcium levels assessed...
February 8, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28164120/coronary-computed-tomography-angiography-in-combination-with-coronary-artery-calcium-scoring-for-the-preoperative-cardiac-evaluation-of-liver-transplant-recipients
#17
REVIEW
Jae Moon Choi, Yu-Gyeong Kong, Joon-Won Kang, Young-Kug Kim
Liver transplantation is the best treatment option for early-stage hepatocellular carcinoma, liver cirrhosis, fulminant liver failure, and end-stage liver diseases. Even though advances in surgical techniques and perioperative care have improved postoperative outcomes, perioperative cardiovascular complications are a leading cause of postoperative morbidity and mortality following liver transplantation. Ischemic coronary artery disease (CAD) and cardiomyopathy are the most common cardiovascular diseases and could be negative predictors of postoperative outcomes in liver transplant recipients...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28155141/compliance-to-the-joint-commission-proposed-core-measure-set-on-osteoporosis-associated-fracture-review-of-different-secondary-fracture-prevention-programs-in-an-open-medical-system-from-2010-to-2015
#18
Ma Conchitina Fojas, Lauren T Southerland, Laura S Phieffer, Julie A Stephens, Tanya Srivastava, Steven W Ing
: There are care gaps in the evaluation and treatment of osteoporosis after a fragility fracture. The Joint Commission is considering adoption of core measures. We compared compliance between two secondary fracture prevention programs in our institution. Incorporating strengths of both may provide the best outcomes for secondary fracture prevention. PURPOSE: There are significant care gaps in the evaluation and treatment of osteoporosis after occurrence of fragility fracture...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28151934/hepatitis-b-virus-modulates-store-operated-calcium-entry-to-enhance-viral-replication-in-primary-hepatocytes
#19
Jessica C Casciano, Nicholas J Duchemin, R Jason Lamontagne, Laura F Steel, Michael J Bouchard
Many viruses modulate calcium (Ca2+) signaling to create a cellular environment that is more permissive to viral replication, but for most viruses that regulate Ca2+ signaling, the mechanism underlying this regulation is not well understood. The hepatitis B virus (HBV) HBx protein modulates cytosolic Ca2+ levels to stimulate HBV replication in some liver cell lines. A chronic HBV infection is associated with life-threatening liver diseases, including hepatocellular carcinoma (HCC), and HBx modulation of cytosolic Ca2+ levels could have an important role in HBV pathogenesis...
2017: PloS One
https://www.readbyqxmd.com/read/28150525/role-of-homocysteine-and-folic-acid-on-the-altered-calcium-homeostasis-of-platelets-from-rats-with-biliary-cirrhosis
#20
Paola Romecín, Noemí M Atucha, Esther G Navarro, M Clara Ortiz, David Iyú, Juan Antonio Rosado, Joaquín García-Estañ
Previously, we have found that intracellular calcium homeostasis is altered in platelets from an experimental model of liver cirrhosis, the bile-duct ligated (BDL) rat; these alterations are compatible with the existence of a hypercoagulable state. Different studies indicate that cholestatic diseases are associated with hyperhomocysteinemia; thus, we hypothetized that it could contribute to those platelet alterations. In the present study, we have investigated the role of homocysteine (HCY) in platelet aggregation and calcium signaling in the BDL model...
February 2, 2017: Platelets
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