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https://www.readbyqxmd.com/read/28108730/the-relationship-between-liver-kidney-impairment-and-viral-load-after-nephropathogenic-infectious-bronchitis-virus-infection-in-embryonic-chickens
#1
Qiqi Huang, Xiaona Gao, Ping Liu, Huayuan Lin, Weilian Liu, Guohui Liu, Jin Zhang, Guangfu Deng, Caiying Zhang, Huabin Cao, Xiaoquan Guo, Guoliang Hu
To examine the relationship of impairments of the liver and kidney with viral load after nephropathogenic infectious bronchitis virus (NIBV) infection in embryonic chickens, 120 specific-pathogen-free Leghorn embryonated chicken eggs were randomly divided into two groups (infected and control), with three replicates per group and 20 eggs in each replicate. The eggs in the infected and control groups were challenged with 0.2 mL of 10(5.5) ELD50 NIBV and sterile saline solution, respectively. The embryonic chickens' plasma and liver and kidney tissues were collected at 1, 3, and 5 days post-inoculation (dpi), the liver and kidney functional parameters were quantified, and the tissue viral loads were determined with real-time PCR...
January 20, 2017: Poultry Science
https://www.readbyqxmd.com/read/28103584/significant-efficacy-and-well-safety-of-apatinib-in-an-advanced-liver-cancer-patient-a-case-report-and-literature-review
#2
Peisi Kou, Yan Zhang, Wenbo Shao, Hui Zhu, Jingze Zhang, Haiyong Wang, Li Kong, Jinming Yu
Apatinib is a novel and highly selective tyrosine kinase inhibitor of vascular endothelial growth factor receptor-2. Previous studies have suggested that apatinib is safe and effective in some solid tumors. We report one case with advanced hepatocellular carcinoma (HCC), who received apatinib combined with transhepatic arterial chemotherapy and embolization (TACE), and chemotherapy respectively. TACE was administered three times once a month, using lipiodol 10ml, oxaliplatin 150mg, and tegafur 1g. The dose of apatinib was 500 mg/d from day 4 to 24...
January 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28098450/the-serum-amyloid-p-component-sap-interactome-in-human-plasma-containing-physiological-calcium-levels
#3
Ebbe Toftgaard Poulsen, Kata Wolff Pedersen, Anna Maria Marzeda, Jan Johannes Enghild
The pentraxin serum amyloid p component (SAP) is secreted by the liver and found in plasma at a concentration of approximately 30 mg/L. SAP is a 25 kDa homo-pentamer known to bind both protein and non-protein ligands, all in a calcium-dependent manner. The function of SAP is unclear, but likely involves the humoral innate immune system spanning the complement system, inflammation, and coagulation. Also, SAP is known to binding to the generic structure of amyloid deposits and possibly to protect these against proteolysis...
January 18, 2017: Biochemistry
https://www.readbyqxmd.com/read/28073952/alcohol-and-coronary-artery-calcification-an-investigation-using-alcohol-flushing-as-an-instrumental-variable
#4
Kyung Eun Yun, Yoosoo Chang, Sung-Cheol Yun, George Davey Smith, Seungho Ryu, Sung-Il Cho, Eun Chul Chung, Hocheol Shin, Young-Ho Khang
BACKGROUND: We examined whether alcohol flushing could be used as an instrumental variable (IV) and investigated the effect of alcohol consumption on coronary calcification using alcohol flushing status as an IV. METHODS: We analysed cross-sectional data from 24 681 Korean adults (20 696 men and 3985 women) who had been administered a questionnaire assessing alcohol consumption and alcohol flushing, as well as a coronary artery calcium (CAC) measurement. The associations of alcohol flushing status with potential confounders and alcohol consumption were examined...
January 10, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28070860/energetic-oxidative-and-ionic-exchange-in-rat-brain-and-liver-mitochondria-at-experimental-audiogenic-epilepsy-krushinsky-molodkina-model
#5
Natalya I Venediktova, Olga S Gorbacheva, Natalia V Belosludtseva, Irina B Fedotova, Natalia M Surina, Inga I Poletaeva, Oleg V Kolomytkin, Galina D Mironova
The role of brain and liver mitochondria at epileptic seizure was studied on Krushinsky-Molodkina (KM) rats which respond to sound with an intensive epileptic seizure (audiogenic epilepsy). We didn't find significant changes in respiration rats of brain and liver mitochondria of KM and control rats; however the efficiency of АТР synthesis in the KM rat mitochondria was 10% lower. In rats with audiogenic epilepsy the concentration of oxidative stress marker malondialdehyde in mitochondria of the brain (but not liver) was 2-fold higher than that in the control rats...
January 9, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28070107/effects-of-reduced-food-intake-for-4-weeks-on-physiological-parameters-in-toxicity-studies-in-dogs
#6
Junya Morita, Tomoko Izumi, Bunichiro Ogawa, Yoshiki Ban, Hironori Takagi, Minoru Sasaki, Shunsuke Tsutsumi
This study sought to clarify the effects of reduced feeding on physiological parameters in dogs to enable appropriate evaluations of the safety and toxicity of test compounds. We measured alkaline phosphatase isozymes and the circulating blood volume, as well as clinical signs, body weight, hematology, blood chemistry, electrocardiography, organ weight, and histopathology, in male beagle dogs fed a diet consisting of 300 g/day or 150 g/day for 4 weeks. There were no abnormal clinical signs in any of the dogs...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28068422/correction-calcium-reduces-liver-injury-in-mice-on-a-high-fat-diet-alterations-in-microbial-and-bile-acid-profiles
#7
Muhammad Nadeem Aslam, Christine M Bassis, Li Zhang, Sameer Zaidi, James Varani, Ingrid L Bergin
[This corrects the article DOI: 10.1371/journal.pone.0166178.].
2017: PloS One
https://www.readbyqxmd.com/read/28067989/tacrolimus-interaction-with-nafcillin-resulting-in-significant-decreases-in-tacrolimus-concentrations-a-case-report
#8
Minkey Wungwattana, Marizela Savic
Tacrolimus (TAC) is subject to many drug interactions as a result of its metabolism primarily via CYP450 isoenzyme 3A4. Numerous case reports of TAC and CYP3A4 inducers and inhibitors have been described including antimicrobials, calcium channel antagonists, and antiepileptic drugs. We present the case of a 13-year-old patient with cystic fibrosis and a history of liver transplantation, where subtherapeutic TAC concentrations were suspected to be a result of concomitant TAC and nafcillin (NAF) therapy. The observed drug interaction occurred on two separate hospital admissions, during both of which the patient exhibited therapeutic TAC concentrations prior to exposure to NAF, a CYP3A4 inducer...
January 9, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28064001/endoplasmic-reticulum-mitochondria-calcium-signalling-in-hepatic-metabolic-diseases
#9
REVIEW
Jennifer Rieusset
The liver plays a central role in glucose homeostasis, and both metabolic inflexibility and insulin resistance predispose to the development of hepatic metabolic diseases. Mitochondria and endoplasmic reticulum (ER), which play a key role in the control of hepatic metabolism, also interact at contact points defined as mitochondria-associated membranes (MAM), in order to exchange metabolites and calcium (Ca(2+)) and regulate cellular homeostasis and signaling. Here, we overview the role of the liver in the control of glucose homeostasis, mainly focusing on the independent involvement of mitochondria, ER and Ca(2+) signaling in both healthy and pathological contexts...
January 4, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28058631/induction-of-apoptosis-of-liver-cancer-cells-by-nanosecond-pulsed-electric-fields-nspefs
#10
Ling He, Deyou Xiao, Jianguo Feng, Chenguo Yao, Liling Tang
The application of nanosecond pulsed electric fields (nsPEFs) is a novel method to induce the death of cancer cells. NsPEFs could directly function on the cell membrane and activate the apoptosis pathways, then induce apoptosis in various cell lines. However, the nsPEFs-inducing-apoptosis action sites and the exact pathways are not clear now. In this study, nsPEFs were applied to the human liver cancer cells HepG2 with different parameters. By apoptosis assay, morphological observation, detecting the mitochondrial membrane potential (ΔΨ m), intracellular calcium ion concentration ([Ca(2+)]i) and the expressions of key apoptosis factors, we demonstrated that nsPEFs could induce the morphology of cell apoptosis, the change in ΔΨ m, [Ca(2+)]i and the upregulation of some key apoptosis factors, which revealed the responses of liver cancer cells and indicated that cells may undergo apoptosis through the mitochondria-dependent pathway after nsPEFs were applied...
February 2017: Medical Oncology
https://www.readbyqxmd.com/read/28057911/guanosine-5-monophosphate-chelated-calcium-and-iron-feed-additives-maintains-egg-production-and-prevents-salmonella-gallinarum-in-experimentally-infected-layers
#11
Hye-Ji Noh, HeeKyong Kim, Su Jeong Heo, Hyang Hyun Cho, Hong Bum Koh
We evaluated the effects of guanosine 5'-monophosphate (GMP) -chelated calcium and iron (CaFe-GMP) on the health and egg quality in layers experimentally infected with Salmonella Gallinarum. In this study, CaFe-GMP feed additives was fed with commercial layer feed to layer over four weeks and all were inoculated with Salmonella Gallinarum. Body weight, mortality, clinical symptoms, and poultry production including feed intake, egg production, egg loss, and feed conversion rate were observed and Salmonella Gallinarum was re-isolated from the liver, spleen, and cecum of the layers...
January 4, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28056732/development-of-a-radiolabeled-amlodipine-analog-for-l-type-calcium-channel-imaging
#12
Tahereh Firouzyar, Amir Reza Jalilian, Mohammad Reza Aboudzadeh, Hossein Sadeghpour, Mehrban Pooladi, Mahdi Shafiee-Ardestani, Ali Khalaj
PURPOSE: The non-invasive imaging and quantification of L-type calcium channels in living tissues is of great interest in diagnosis of congestive heart failure, myocardial hypertrophy, irritable bowel syndrome etc. METHODS: Technetium-<sup>99m</sup> labeled amlodipine conjugate ([<sup>99m</sup>Tc]-DTPA-AMLO) was prepared starting freshly eluted (<1 h) <sup>99m</sup>Technetium pertechnetate (86.5 MBq) and conjugated DTPA-AMLO at pH 5 in 30 min at room temperature in high radiochemical purity (>99%, RTLC; specific activity: 55-60 GBq/mmol)...
January 4, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28056419/chamomile-matricaria-recutita-l-decoction-extract-inhibits-in-vitro-intestinal-glucose-absorption-and-attenuates-high-fat-diet-induced-lipotoxicity-and-oxidative-stress
#13
Mohamed-Amine Jabri, Mohsen Sakly, Lamjed Marzouki, Hichem Sebai
The present study aimed to investigate the inhibitory effect of chamomile decoction extract (CDE) on intestinal glucose absorption as well as its protective role against high fat diet (HFD)-induced obesity and lipotoxicity in rats. We used the Ussing chamber system to investigate the effect of CDE on intestinal transport of glucose. Male Wistar rats were fed HFD for six weeks to provoke obesity. CDE (100mg/kg, b.w. p.o.) has been per orally administered to HFD fed rats. Ex vivo, we found that CDE significantly and dose-dependently increased intestinal absorption of glucose...
January 2, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28052355/mitochondrial-ryanodine-sensitive-ca-2-channels-of-rat-liver
#14
N I Kupynyak, O V Ikkert, S G Shlykov, L G Babich, V V Manko
To examine ryanodine-sensitive Ca(2+) channels in mitochondria of rat hepatocytes and their role in energy state of the cells via investigation of the ryanodine effect on mitochondrial membrane potential. Oxygen consumption was measured by polarography using the Clark electrode. The substrates of oxidation such as pyruvate (5mM), α-ketoglutarate (5mM), or succinate (5mM) were used. Oxidative phosphorylation was stimulated by the addition of adenosine diphosphate (200nM). Mitochondrial membrane potential was measured using a voltage-sensitive fluorescent probe tetramethylrhodamine-methyl-ester (0...
January 3, 2017: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/28042884/pharmacokinetics-of-the-antimicrobial-drug-sulfanilamide-is-altered-in-a-preclinical-model-of-vascular-calcification
#15
Anabel Brandoni, Adriana Mónica Torres
In vascular smooth muscle, calcium overload is linked to advancing age. The pharmacokinetics of sulfanilamide (SA), a compound with antibacterial properties, was evaluated in a preclinical model of vascular calcification. SA was used since it is useful to study possible modifications in the renal and hepatic management of drugs. Vascular calcification was induced by administration of a single high dose of vitamin D3 to rats (treated group) 10 days before the experiments. A parallel control group was processed...
January 2, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28012149/endoplasmic-reticulum-stress-and-apoptosis-triggered-by-sub-chronic-lead-exposure-in-mice-spleen-a-histopathological-study
#16
Giovanni Corsetti, Claudia Romano, Alessandra Stacchiotti, Evasio Pasini, Francesco S Dioguardi
Lead (Pb) is an environmental oncogenic metal that induces immunotoxicity and anaemia. Emerging evidence has linked Pb toxicity with endoplasmic reticulum-driven apoptosis and autophagy. Glucose-regulated protein of 78 kDa (Grp78 or binding immunoglobulin protein (BiP)), a master endoplasmic reticulum chaperone, drives macrophage activation and regulates protein folding and calcium flux in response to heavy metals. The spleen may be involved in Pb poisoning due to its crucial role in erythrocatheresis and immune response, although there are no data to support this theory...
December 24, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/28005961/comparative-transcriptomic-study-of-muscle-provides-new-insights-into-the-growth-superiority-of-a-novel-grouper-hybrid
#17
Ying Sun, Yu Huang, Guojun Hu, Xinhui Zhang, Zhiqiang Ruan, Xiaomeng Zhao, Chuanyu Guo, Zhujing Tang, Xiaofeng Li, Xinxin You, Haoran Lin, Yong Zhang, Qiong Shi
Grouper (Epinephelus spp.) is a group of fish species with great economic importance in Asian countries. A novel hybrid grouper, generated by us and called the Hulong grouper (Hyb), has better growth performance than its parents, E. fuscoguttatus (Efu, ♀) and E. lanceolatus (Ela, ♂). We previously reported that the GH/IGF (growth hormone/insulin-like growth factor) system in the brain and liver contributed to the superior growth of the Hyb. In this study, using transcriptome sequencing (RNA-seq) and quantitative real-time PCR (qRT-PCR), we analyzed RNA expression levels of comprehensive genes in the muscle of the hybrid and its parents...
2016: PloS One
https://www.readbyqxmd.com/read/28005946/the-mitochondrial-permeability-transition-pore-regulator-cyclophilin-d-exhibits-tissue-specific-control-of-metabolic-homeostasis
#18
Rhianna C Laker, Evan P Taddeo, Yasir N Akhtar, Mei Zhang, Kyle L Hoehn, Zhen Yan
The mitochondrial permeability transition pore (mPTP) is a key regulator of mitochondrial function that has been implicated in the pathogenesis of metabolic disease. Cyclophilin D (CypD) is a critical regulator that directly binds to mPTP constituents to facilitate the pore opening. We previously found that global CypD knockout mice (KO) are protected from diet-induced glucose intolerance; however, the tissue-specific function of CypD and mPTP, particularly in the control of glucose homeostasis, has not been ascertained...
2016: PloS One
https://www.readbyqxmd.com/read/27995414/na-h-exchanger-3-inhibitor-diminishes-hepcidin-enhanced-duodenal-calcium-transport-in-hemizygous-%C3%AE-globin-knockout-thalassemic-mice
#19
Narattaphol Charoenphandhu, Kamonshanok Kraidith, Kornkamon Lertsuwan, Chanakarn Sripong, Panan Suntornsaratoon, Saovaros Svasti, Nateetip Krishnamra, Kannikar Wongdee
Recent investigation has shown that the liver-derived iron-regulating hormone, hepcidin, can potentiate intestinal calcium absorption in hemizygous β-globin knockout thalassemic (BKO) mice. Since the upregulation of Fe(2+) and H(+) cotransporter, divalent metal transporter (DMT)-1, has been shown to correlate with thalassemia-induced intestinal calcium absorption impairment, the inhibition of the apical Na(+)/H(+) exchanger (NHE)-3 that is essential for cytoplasmic pH regulation and transepithelial sodium absorption was hypothesized to negatively affect hepcidin action...
December 19, 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27991906/hepatic-stimulator-substance-inhibits-calcium-overflow-through-the-mitochondria-associated-membrane-compartment-during-nonalcoholic-steatohepatitis
#20
Fan Xiao, Jing Zhang, Can Zhang, Wei An
Nonalcoholic fatty liver disease is considered a disorder of the endoplasmic reticulum (ER) and mitochondria. Recent studies have shown that the ER and mitochondrial membranes overlap by 15-20%, a region referred to as the 'mitochondria-associated ER membrane' (MAM). Some proteins, including sarco/ER calcium ATPase (SERCA), are located in the MAM and have an important role in Ca(2+) signaling and homeostasis between the ER and the mitochondria. Our previous study showed that hepatic stimulator substance (HSS) inhibits the ER stress induced by reactive oxygen species, thus reducing mitochondrial damage...
December 19, 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
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