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https://www.readbyqxmd.com/read/29314152/optimization-of-pressurized-liquid-extraction-by-response-surface-methodology-of-goji-berry-lycium-barbarum-l-phenolic-bioactive-compounds
#1
Giusy Tripodo, Elena Ibáñez, Alejandro Cifuentes, Bienvenida Gilbert-Lopez, Chiara Fanali
Pressurized liquid extraction (PLE) has been used for the first time in this work to extract phenolic compounds from Goji berries according to a multilevel factorial design using response surface methodology. The global yield (% w/dw, weight/dry-weight), total phenolic content (TPC), total flavonoid (TF) and antioxidant activity (determined via ABTS assay, expressed as TEAC value) were used as response variables to study the effects of temperature (50-180°C) and green solvent composition (mixtures of ethanol/water)...
January 3, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29283972/prognostic-significance-of-day-by-day-variability-of-home-blood-pressure-on-progression-to-macroalbuminuria-in-patients-with-diabetes
#2
Emi Ushigome, Shinobu Matsumoto, Chikako Oyabu, Noriyuki Kitagawa, Toru Tanaka, Goji Hasegawa, Masayoshi Ohnishi, Sei Tsunoda, Hidetaka Ushigome, Isao Yokota, Naoto Nakamura, Yohei Oda, Mai Asano, Muhei Tanaka, Masahiro Yamazaki, Michiaki Fukui
OBJECTIVES: Previously, we have shown in cross-sectional analysis of patients with type 2 diabetes mellitus that the presence of diabetic nephropathy is associated with increased home blood pressure (HBP) variability. We now examine the prognostic significance of HBP variability in substantially the same cohort. METHODS: We performed a prospective cohort study of type 2 diabetes patients. We analyzed 714 patients. Major exclusion criteria are missing data of urinary albumin excretion and newly prescribed or stopped renin-angiotensin system inhibitors during 2-year follow-up...
December 27, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29259825/corrigendum-to-relationship-between-the-direction-of-ophthalmic-artery-blood-flow-and-ocular-microcirculation-before-and-after-carotid-artery-stenting
#3
Masashi Ishii, Morito Hayashi, Fumihiko Yagi, Kenichiro Sato, Goji Tomita, Satoshi Iwabuchi
[This corrects the article DOI: 10.1155/2016/2530914.].
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29214141/new-trends-in-anaphylaxis
#4
REVIEW
Margitta Worm, Gunter Sturm, Jörg Kleine-Tebbe, Ewa Cichocka-Jarosz, Victoria Cardona, Ioana Maris, Sabine Dölle
This review presents the current trends in anaphylaxis management discussed at the fourth International Network for Online-Registration of Anaphylaxis (NORA) conference held in Berlin in April 2017. Current data from the anaphylaxis registry show that Hymenoptera venom, foods, and pharmaceutical drugs are still among the most frequent triggers of anaphylaxis. Rare triggers include chicory, cardamom, asparagus, and goji berries. A meta-analysis on recent trends in insect venom anaphylaxis demonstrated for the first time that, although data on the efficacy of insect venom immunotherapy is limited, the occurrence of severe reactions upon repeated sting events can be prevented and patients' quality of life improved...
2017: Allergo Journal International
https://www.readbyqxmd.com/read/29192436/-advances-in-research-on-relationships-among-lycium-species-and-origin-of-cultivated-lycium-in-china
#5
REVIEW
Dan Qian, Rui-Feng Ji, Wei Gao, Lu-Qi Huang
The Lycium genus consists of consist of 7 species and 3 variety which are main distributed in Northwest region in China, the cultivated Goji berry appeared about 1 000 years ago. The phylogeny of the wild Goji berry and the domestication of cultivated Goji berry are important scientific and practical value due to the medicinal and economic value. In this paper, a new advances achieved in studies on the phylogeny of wild Goji berry is summarized. The origin of cultivated Goji berry includes when, where, how and ancestral specie were reviewed...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29125846/characterization-of-the-lycium-barbarum-fruit-transcriptome-and-development-of-est-ssr-markers
#6
Chunling Chen, Meilong Xu, Cuiping Wang, Gaixia Qiao, Wenwen Wang, Zhaoyun Tan, Tiantian Wu, Zhengsheng Zhang
Lycium barbarum, commonly known as goji, is important in Chinese herbal medicine and its fruit is a very important agricultural and biological product. However, the molecular mechanism of formation of its fruit and associated medicinal and nutritional components is unexplored. Moreover, this species lacks SSR markers due to lack of genomic and transcriptomic information. In this study, a total of 139,333 unigenes with average length of 1049 bp and N50 of 1579 bp are obtained by trinity assembly from Illumina sequencing reads...
2017: PloS One
https://www.readbyqxmd.com/read/29115477/effects-of-lycium-barbarum-goji-berry-on-dry-eye-disease-in-rats
#7
Kaung-Jen Chien, Chi-Ting Horng, Yu-Syuan Huang, Yi-Hsien Hsieh, Chau-Jong Wang, Jai-Sing Yang, Chi-Cheng Lu, Fu-An Chen
Lycium barbarum (goji berry) has long been used as a food and traditional herbal medicine. This study aimed to investigate the beneficial effect of the goji berry on dry eye disease in rats. Male Sprague‑Dawley rats with induced dry eye disease were randomly assigned to four groups: Vehicle (control), low‑dose goji berry extract [GBE; 250 mg/kg/body weight (bw)], median‑dose GBE (350 mg/kg/bw), and high‑dose GBE (500 mg/kg/bw). Three methods, Schirmer's test, tear break‑up time (BUT) measurement and keratoconjunctival fluorescein staining, were used to evaluate the effect of GBE on symptoms of dry eye disease experienced by the rats...
November 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29038291/cystine-uptake-through-the-cystine-glutamate-antiporter-xct-triggers-glioblastoma-cell-death-under-glucose-deprivation
#8
Takeo Goji, Kazuhiko Takahara, Manabu Negishi, Hironori Katoh
Oncogenic signaling in cancer cells alters glucose uptake and utilization to supply sufficient energy and biosynthetic intermediates for survival and sustained proliferation. Oncogenic signaling also prevents oxidative stress and cell death caused by increased production of reactive oxygen species (ROS). However, elevated glucose metabolism in cancer cells, especially in glioblastoma, results in the cells becoming sensitive to glucose deprivation (i.e. in high glucose dependence), which rapidly induces cell death...
October 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29028333/profiling-and-quantification-of-regioisomeric-caffeoyl-glucoses-in-berry-fruits
#9
Maria Alexandra Patras, Nikolai Kuhnert, Rakesh Jaiswal, Gordon J McDougall
Based on a recently developed tandem MS based hierarchical scheme for the identification of regioisomeric caffeoyl glucoses, selected berry fruits were profiled for their caffeoyl glucose ester content. Fresh edible berries profiled included strawberries, raspberries, blueberries, blackberries, red and black currants, lingonberries, gooseberries, cranberries, juice of elderberries, goji berries, chokeberries, cranberries, açai berries, sea buckthorn berries, Montmorency sour cherries, and pomegranate were investigated...
October 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28925271/-the-results-of-five-years-follow-up-prospective-study-of%C3%A2-vaginal-prolapse-repaired-by-prolift-total-mesh-surgery-or%C3%A2-sacrospinous-fixation
#10
P Kraus, L Krofta, M Krčmář, I Urbánková, O Gojiš, K Grogregin, J Feyereisl
OBJECTIVE: The aim of the study is to compare the results of five years follow-up prospective study of vaginal prolapse repaired by prolift total mesh surgery or sacrospinous fixation. STUDY DESIGN: A single-center prospective, cohort study, in patients with defect grade II and more by POP-Q. SETTING: The Institute for the Care of Mather and Child; 3rd Medical Faculty Charles university, Prague. METHODS: Comparison of the preoperative state and the five years after the operation according POP Q, ICIQ-SF, PISQ 12, VAS...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28925270/-reconstruction-of-the-posterior-and-central-compartment-with-the-prolift-posterior-cohort-study-with-a-5-year-follow-up
#11
K Brányik, L Krofta, P Kraus, M Krčmář, O Gojiš, I Urbánková, J Feyereisl
OBJECTIVE: To analyse the results of the long-term prospective follow-up study of vaginal prolapse reconstructed using a Prolift Posterior. STUDY DESIGN: Prospective, cohort study. SETTING: Institute for the Care of Mother and Child, Prague. METHODS: Over a 5-year period (I/2006 - XII/2011) we prospectively followed a cohort of patients with posterior vaginal wall defect who underwent surgical reconstruction using a monofilament polypropylene implant Prolift Posterior (Gynecare, Ethicon, Inc...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28911025/home-blood-pressure-variability-from-the-stored-memory-is-correlated-with-albuminuria-but-from-the-logbook-is-not
#12
Shinobu Matsumoto, Emi Ushigome, Kanae Matsushita, Takuya Fukuda, Kazuteru Mitsuhashi, Saori Majima, Goji Hasegawa, Naoto Nakamura, Hidetaka Ushigome, Masahiro Yamazaki, Michiaki Fukui
BACKGROUND: The aim of this study was to evaluate whether the mean and the variability of home blood pressure (HBP) from the logbook correlate with albuminuria as well as HBP from the stored memory in patients with type 2 diabetes. METHODS: This study is a post hoc analysis of a cross-sectional multicenter study. HBP measurements were performed for 14 consecutive days in 276 patients with type 2 diabetes. Patients were requested to write down their HBP values in logbooks and were not informed about the memory function of their BP monitoring devices...
October 1, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28828482/determinants-and-characteristics-of-bruch-s-membrane-opening-and-bruch-s-membrane-opening-minimum-rim-width-in-a-normal-japanese-population
#13
Makoto Araie, Aiko Iwase, Kazuhisa Sugiyama, Toru Nakazawa, Goji Tomita, Masanori Hangai, Yasuo Yanagi, Hiroshi Murata, Hidenobu Tanihara, Claude F Burgoyne, Balwantray C Chauhan
Purpose: To identify determinants of Bruch's membrane opening (BMO), and BMO-minimum rim width (BMO-MRW) and circumpapillary retinal nerve fiber layer thickness (RNFLT) centered on BMO center and characterize these parameters in a normal Japanese population. Methods: Spectral-domain optical coherence tomography images of optic nerve head and circumpapillary and macular retina were obtained in 258 eyes of 258 normal Japanese with mean (standard deviation) age of 51...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28819987/maximum-home-blood-pressure-is-a-useful-indicator-of-diabetic-nephropathy-in-patients-with-type-2-diabetes-mellitus-kamogawa-hbp-study
#14
Chikako Oyabu, Emi Ushigome, Shinobu Matsumoto, Toru Tanaka, Goji Hasegawa, Naoto Nakamura, Masayoshi Ohnishi, Sei Tsunoda, Hidetaka Ushigome, Isao Yokota, Muhei Tanaka, Mai Asano, Masahiro Yamazaki, Michiaki Fukui
OBJECTIVE: Maximum home systolic blood pressure has been shown to predict target organ damage. We aimed to clarify the association between maximum home systolic blood pressure and urine albumin to creatinine ratio, an indicator of early-phase diabetic nephropathy in patients with type 2 diabetes. METHODS: In 1040 patients, we assessed the relationship of mean or maximum home systolic blood pressure and urine albumin to creatinine ratio, and compared the area under the receiver operating characteristic curve of mean or maximum home systolic blood pressure for diabetic nephropathy (urine albumin to creatinine ratio ⩾30 mg/g Cr)...
August 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28807784/gabapentin-prevents-cortical-spreading-depolarization-induced-disinhibition
#15
Masoud Mesgari, Johanna Krüger, Christopher Theo Riemer, Maryam Khaleghi Ghadiri, Stjepana Kovac, Ali Gorji
Cortical spreading depolarization (CSD) has an important role in brain diseases such as stroke, subarachnoid hemorrhage, migraine with aura, and epilepsy. Several anti-epileptic drugs (AEDs) are used to treat paroxysmal brain diseases and are thus known to suppress CSD. One of these AEDs is gabapentin (GBP) which has been traditionally used for treatment of some CSD-related neurological diseases. We applied intra- and extracellular recordings to investigate the effect of CSD on inhibitory post synaptic potentials (IPSPs) and synaptic properties of rodent neocortex after application of GBP...
August 12, 2017: Neuroscience
https://www.readbyqxmd.com/read/28791128/the-first-japanese-patient-with-mandibular-hypoplasia-deafness-progeroid-features-and-lipodystrophy-diagnosed-via-pold1-mutation-detection
#16
Asami Okada, Tomohiro Kohmoto, Takuya Naruto, Ichiro Yokota, Yumiko Kotani, Aki Shimada, Yoko Miyamoto, Rizu Takahashi, Aya Goji, Kiyoshi Masuda, Shoji Kagami, Issei Imoto
Mandibular hypoplasia, deafness, progeroid features and lipodystrophy (MDPL) syndrome is a rare autosomal dominant disorder caused by heterozygous POLD1 mutations. To date, 13 patients affected by POLD1 mutation-caused MDPL have been described. We report a clinically undiagnosed 11-year-old male who noted joint contractures at 6 years of age. Targeted exome sequencing identified a known POLD1 mutation [NM_002691.3:c.1812_1814del, p.(Ser605del)] that diagnosed him as the first Japanese/East Asian MDPL case.
2017: Human Genome Variation
https://www.readbyqxmd.com/read/28761569/efficacy-and-safety-of-switching-from-prostaglandin-analog-therapy-to-prostaglandin-timolol-fixed-combination-or-prostaglandin-brimonidine-therapy
#17
Kenji Inoue, Mieko Masumoto, Kyoko Ishida, Goji Tomita
BACKGROUND: To compare the safety and efficacy between switching to prostaglandin/timolol fixed combination eye drops (PG/timolol FCs) and adding brimonidine to PG analogue monotherapy. METHODS: Eyes of 53 patients with primary open-angle glaucoma or ocular hypertension who were receiving PG analogue monotherapy were included. Participants were randomly divided into two treatment groups: one was prescribed PG/timolol FCs (switched group), and for the other, 0.1% brimonidine was added to the PG analogue (added group)...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28739100/movement-of-retinal-vessels-toward-the-optic-nerve-head-after-increasing-intraocular-pressure-in-monkey-eyes-with-experimental-glaucoma
#18
Atsumi Kuroda, Nobuko Enomoto, Kyoko Ishida, Masamitsu Shimazawa, Tetsuro Noguchi, Naoto Horai, Hirotaka Onoe, Hideaki Hara, Goji Tomita
A shift or displacement of the retinal blood vessels (RBVs) with neuroretinal rim thinning indicates the progression of glaucomatous optic neuropathy. In chronic open angle glaucoma, individuals with RBV positional shifts exhibit more rapid visual field loss than those without RBV shifts. The retinal vessels reportedly move onto the optic nerve head (ONH) in response to glaucoma damage, suggesting that RBVs are pulled toward the ONH in response to increased cupping. Whether this phenomenon only applies to RVBs located in the vicinity or inside the ONH or, more generally, to RBVs also located far from the ONH, however, is unclear...
September 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28721006/incidence-of-outer-retinal-tubulation-in-eyes-with-choroidal-neovascularization-under-intravitreal-anti-vascular-endothelial-growth-factor-therapy-in-a-japanese-population
#19
Seiji Takagi, Michiko Mandai, Noriko Miyamoto, Akihiro Nishida, Yasuhiko Hirami, Hirofumi Uyama, Midori Yamamoto, Masayo Takahashi, Goji Tomita, Yasuo Kurimoto
PURPOSE: The purpose of this study was to investigate the occurrence of outer retinal tubulation (ORT) among patients with different types of choroidal neovascularization (CNV) over time. MATERIALS AND METHODS: In this retrospective chart review, disease type was classified as typical age-related macular degeneration (t-AMD), polypoidal choroidal vasculopathy (PCV), retinal angiomatous proliferation (RAP), or myopic CNV (mCNV). Spectral domain-optical coherence tomography (SD-OCT) images were evaluated for the appearance of ORT and subretinal fibrosis and fluid...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28698359/egfr-downregulation-after-anti-egfr-therapy-predicts-the-antitumor-effect-in-colorectal-cancer
#20
Yasuyuki Okada, Tetsuo Kimura, Tadahiko Nakagawa, Koichi Okamoto, Akira Fukuya, Takahiro Goji, Shota Fujimoto, Masahiro Sogabe, Hiroshi Miyamoto, Naoki Muguruma, Yasushi Tsuji, Toshiya Okahisa, Tetsuji Takayama
Anti-EGFR mAb is reported to induce EGFR internalization in colorectal cancer cells. However, the biological relevance of EGFR internalization with anti-EGFR mAb is unknown. Therefore, the relevance of EGFR downregulation with anti-EGFR mAb to antitumor activity in colorectal cancer cells was investigated. Quantification of EGFR on the cell surface before cetuximab treatment was assessed by flow cytometry, and its growth-inhibitory effects were measured by Trypan blue exclusion, in 10 RAS, BRAF wild-type colorectal cancer cell lines, but there was no significant correlation between EGFR number and its growth-inhibitory effect...
July 11, 2017: Molecular Cancer Research: MCR
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