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Maria Campos, C Batista, N R Jesus, C M Silva, T P Silva
Cardiovascular patients frequently use herbal medicinal products, in order to contribute to the improvement of their chronic condition without medical intervention. However, they are likely to suffer from adverse effects from natural products and herb-drug interactions. This work aimed to alert cardiovascular patients and healthcare providers of the potential of occurrence of herb-drug interactions with cardiovascular therapy. Information obtained from the campaign "Aprender Saúde Entre as Plantas e os Medicamentos", carried out by the Observatory of Herb-Drug Interactions (www...
October 7, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
Judith Hempel, Christopher N Schädle, Jasmin Sprenger, Annerose Heller, Reinhold Carle, Ralf M Schweiggert
Goji berries (Lycium barbarum L.) have been known to contain strikingly high levels of zeaxanthin, while the physical deposition form and bioaccessibility of the latter was yet unknown. In the present study, we associated ripening-induced modifications in the profile of carotenoids with fundamental changes of the deposition state of carotenoids in goji berries. Unripe fruit contained common chloroplast-specific carotenoids being protein-bound within chloroplastidal thylakoids. The subsequent ripening-induced transformation of chloroplasts to tubular chromoplasts was accompanied by an accumulation of up to 36mg/100g FW zeaxanthin dipalmitate and further minor xanthophyll esters, prevailing in a presumably liquid-crystalline state within the nano-scaled chromoplast tubules...
March 1, 2017: Food Chemistry
Jelena J Vulić, Jasna M Čanadanović-Brunet, Gordana S Ćetković, Sonja M Djilas, Vesna T Tumbas Šaponjac, Sladjana S Stajčić
OBJECTIVE: Goji fruit extracts, methanol (MGE) and hexane (HGE), were subjected to evaluation as potential source of phenolic antioxidants and antiradical activity. METHODS: Some phenolic compounds (gallic, protocatechuic, vanillic, chlorogenic, coumaric, caffeic and ferulic acid and catechin and rutin), vitamin C and carotenoids were identified and quantified by HPLC. Antioxidant activity was tested by measuring ability to scavenge DPPH and hydroxyl radicals. Also, reducing power of goji fruit extracts was determined...
October 6, 2016: Journal of the American College of Nutrition
Guanshen Yuan, Jie Ren, Xiaoyu Ouyang, Liying Wang, Mengze Wang, Xiaodong Shen, Bolin Zhang, Baoqing Zhu
This study investigated the effect of raw material, pressing, and glycosidase on the aromatic profile of goji berry wine. The free-run and the pressed juice of dried and fresh goji berries were used for wine production, whereas glycosidase was applied to wine after fermentation. Dried goji berry fermented wine exhibited much stronger fruity, floral, caramel, and herbaceous odors due to higher levels of esters, β-ionone and methionol. However, fresh berry fermented wine possessed stronger chemical notes due to higher levels of 4-ethylphenol...
October 2, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Hisatsugu Noda, Seiji Noguchi, Takashi Yoshimine, Shigeki Goji, Kazunori Adachi, Yasuhiro Tamura, Shinya Izawa, Masahide Ebi, Sayuri Yamamoto, Naotaka Ogasawara, Yasushi Funaki, Makoto Sasaki, Kunio Kasugai
BACKGROUND AND AIMS: In Japan, 7-day triple therapy for Helicobacter pylori including clarithromycin (CAM) was approved in 2000. However, antibiotic resistance subsequently reduced this rate to an unacceptable level (70%). Vonoprazan, an orally bioavailable potassium-competitive acid blocker (P-CAB), was approved in Japan in 2014. This could improve eradication rates by increasing the intragastric pH, thus increasing bacterial antibiotic susceptibility. This study compared the efficacy of 7-day triple therapies that included CAM and vonoprazan or proton pump inhibitor (PPI)...
September 2016: Journal of Gastrointestinal and Liver Diseases: JGLD
Alicia G Beukers, Rahat Zaheer, Noriko Goji, Shaun R Cook, Kingsley K Amoako, Alexandre V Chaves, Michael P Ward, Tim A McAllister
Here, we report the first draft genome sequence of Enterococcus thailandicus isolated from the feces of feedlot cattle in Southern Alberta.
2016: Genome Announcements
K V Simonyan, L G Avetisyan, V A Chavushyan
Excess fructose consumption causes changes in functioning of the central and peripheral nervous systems, which increase the vulnerability of peripheral nerves to traumatic injury. The aim of this study was to evaluate the electrophysiological parameters of responses of motoneurons of the spinal cord at high-frequency stimulation of the distal part of the injured sciatic nerve in a model of diabetic stress under action of Lycium barbarum (LB). Male albino rats were given with drinking water with 50% concentration of dietary fructose for 6 weeks...
September 2016: Pathophysiology: the Official Journal of the International Society for Pathophysiology
Oliver Hsu, Candy Tsourounis, Lenny Lok Shun Chan, Cathi Dennehy
OBJECTIVES: Chinese herbal medicine (CHM) use has not been well characterized in persons living in the United States who receive care by Western-trained healthcare providers. The primary objective of this study was to characterize use of CHM taken in the last 12 months by patients seen at a Chinatown public health center. DESIGN: Convenience sample survey. SETTING: Data collection occurred over 3 months at a San Francisco Chinatown public health center...
September 2016: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Rui Liu, Teresa W Tam, Jingqin Mao, Ammar Salem, John T Arnason, Anthony Krantis, Brian C Foster
BACKGROUND: Goji berry (Lycium barbarum) has been used as traditional Chinese medicine and a functional food in China. Goji tea may interact with drugs such as warfarin by inhibiting the cytochrome P450 (CYP) 2C9, and this study was undertaken to characterize the effect of Goji products on CYP2C9/19-, CYP2D6 *1/*10-, CYP3A4/5/7-, CYP19-, and flavin-containing monooxygenase (FMO) 3-mediated metabolism. METHODS: Goji juice, water, and ethanol extracts were examined for their effect on CYP2C9/19-, 2D6-, 3A4/5/7-, 4A11-, CYP19-, and FMO3-mediated metabolism by using in vitro bioassay...
June 28, 2016: Journal of Complementary & Integrative Medicine
Toshi Takaoka, Tetsuo Kimura, Rai Shimoyama, Shunji Kawamoto, Kazuki Sakamoto, Fuminori Goda, Hiroshi Miyamoto, Yuji Negoro, Akihito Tsuji, Koji Yoshizaki, Takahiro Goji, Shinji Kitamura, Hiromi Yano, Koichi Okamoto, Masako Kimura, Toshiya Okahisa, Naoki Muguruma, Yoshiro Niitsu, Tetsuji Takayama
BACKGROUND: Irinotecan plus S-1 (IRIS) is the only oral fluoropyrimidine-based regimen reported to be non-inferior to FOLFIRI and widely used in clinical practice for metastatic colorectal cancer (mCRC) patients. However, the combination of IRIS plus an anti-EGFR agent has not been evaluated previously. This study aimed to investigate the feasibility and efficacy of IRIS with panitumumab as second-line therapy for wild-type KRAS mCRC. METHODS: Main inclusion criteria were patients with wild-type KRAS mCRC refractory to one prior chemotherapy regimen for mCRC, ECOG PS 0-2, and age ≥20 years...
August 2016: Cancer Chemotherapy and Pharmacology
Yafei Zhu, Qipeng Zhao, Hua Gao, Xiaodong Peng, Youmin Wen, Guidong Dai
ETHNOPHARMACOLOGICAL RELEVANCE: Lycium barbarum L., popularly known as "Goji berry", a classic of Traditional Chinese Medicine has long been used to treat ocular diseases and cardiovascular diseases. Recently, the photoreceptor cell protection of Lycium barbarum polysaccharides (LBP), a water extract from Lycium barbarum L. has received more attention. The present study was designed to investigate the effect of LBP on N-methyl-N-nitrosourea (MNU)-induced photoreceptor cell apoptosis, and the involvement of the poly (ADP-ribose) polymerase (PARP) and caspase...
September 15, 2016: Journal of Ethnopharmacology
Geisson Marcos Nardi, Adriana Graziele Farias Januario, Cassio Geremia Freire, Fernanda Megiolaro, Kétlin Schneider, Marlene Raimunda Andreola Perazzoli, Scheley Raap Do Nascimento, Ana Cristina Gon, Luísa Nathália Bolda Mariano, Glauber Wagner, Rivaldo Niero, Claudriana Locatelli
BACKGROUND: Many fruits have been used as nutraceuticals because the presence of bioactive molecules that play biological activities. OBJECTIVE: The present study was designed to compare the anti-inflammatory and antioxidant effects of methanolic extracts of Lycium barbarum (GOJI), Vaccinium macrocarpon (CRAN) and Vaccinium myrtillus (BLUE). MATERIALS AND METHODS: Mices were treated with extracts (50 and 200 mg/kg, p.o.), twice a day through 10 days...
March 2016: Pharmacognosy Research
Mayuko Kadono, Naoko Nakanishi, Masahiro Yamazaki, Goji Hasegawa, Naoto Nakamura, Michiaki Fukui
Disruptions to sleep and circadian rhythms have now been recognized as common comorbidities in patients with medical illnesses. We aimed to determine if the diurnal rhythms for rest and activity were disrupted in parallel with the development of diabetic complications. Ninety outpatients in our diabetes clinic who had a body mass index <25 kg m(2) wore an actigraph for 7 consecutive days (42 men; mean age 68.7 ± 8.2 years). Patients with neuropsychiatric diseases, liver cirrhosis, renal failure, chronic obstructive pulmonary disease or blindness, or those who performed shiftwork were excluded...
August 2016: Journal of Sleep Research
Qiuyun Zhang, Weiwei Chen, Jianhua Zhao, Wanpeng Xi
We quantified the levels of polyphenols, carotenoids and polysaccharides in fruits of the eight Chinese native goji genotypes, antioxidant activities of these fruit extracts were also evaluated by DPPH, ABTS and FRAP methods. Quercetin-rhamno-di-hexoside (435-1065 μg/g) and quercetin-3-O-rutinoside (159-629 μg/g) were found to be the predominant flavonoids. Chlorogenic acid was the most abundant phenolic acid (113-526 μg/g), while zeaxanthin (17-9306 μg/g) was the major carotenoid. The total antioxidant activities (TAA) of the berry extracts were significantly correlated with the total polysaccharide and phenolic contents, but not with total carotenoid (TC) levels...
June 1, 2016: Food Chemistry
Sun Shin Yi, Eunmi Hwang, Hye Kyung Baek, Tae-Hee Kim, Hae-Hyeog Lee, Hyun Sik Jun, Sung-Jo Kim
Women's health has been threatened by various diseases mainly including heart disease, breast cancer, osteoporosis, depression, and autoimmune disease. But development of medication for these diseases has been restricted by high development costs and low success rates. Herein the attempt to develop valid bioactive materials from a traditional natural material has been made. Resveratrol has been reported to be effective in treatment of breast cancer and heart disease. Goji berry has received attention as a natural based therapeutic material to treat a diabetes, cardiovascular disease, and osteoporosis...
December 2015: Journal of Menopausal Medicine
Noriyuki Kitagawa, Hiroshi Okada, Muhei Tanaka, Yoshitaka Hashimoto, Toshihiro Kimura, Koji Nakano, Masahiro Yamazaki, Goji Hasegawa, Naoto Nakamura, Michiaki Fukui
The aim of this study was to investigate whether central systolic blood pressure (SBP) was associated with albuminuria, defined as urinary albumin excretion (UAE) ≥30 mg/g creatinine, and, if so, whether the relationship of central SBP with albuminuria was stronger than that of peripheral SBP in patients with type 2 diabetes. The authors performed a cross-sectional study in 294 outpatients with type 2 diabetes. The relationship between peripheral SBP or central SBP and UAE using regression analysis was evaluated, and the odds ratios of peripheral SBP or central SBP were calculated to identify albuminuria using logistic regression model...
August 2016: Journal of Clinical Hypertension
Kenji Inoue, Akira Setogawa, Goji Tomita
PURPOSE: To investigate patients whose intraocular pressure (IOP) did not decrease after treatment using a prostaglandin analog (nonresponders). METHODS: This was an open-label, retrospective, case series study from a single institution. We retrospectively investigated the mean IOP reduction rates, and the proportions of nonresponders, among normal tension glaucoma (NTG) patients (209 cases, 209 eyes) treated using 1 of 4 prostaglandin analogs: latanoprost (40 patients), travoprost (64 patients), tafluprost (52 patients), or bimatoprost (53 patients)...
March 2016: Journal of Ocular Pharmacology and Therapeutics
Goji Tomita, David Huang, Colm O'Brien, Ki Ho Park, Toru Nakazawa
No abstract text is available yet for this article.
2015: BioMed Research International
Anna Wawruszak, Arkadiusz Czerwonka, Karolina Okła, Wojciech Rzeski
The anticancer activity of ethanol extract isolated from Goji berry (EEGB) on T47D human breast cancer cell line has been reported. Cell viability and cell proliferation were examined with the use of BrdU, MTT and NR methods. Induction of apoptosis was assessed by propidium iodide and Hoechst 33342 staining. Expression of genes involved in cell proliferation, apoptosis, cell cycle control and regulation of transcription was estimated using Western blotting analysis. EEGB inhibited the proliferation of breast cancer cells in a time-, and dose-dependent manner...
September 2016: Natural Product Research
Nobuko Enomoto, Ayako Anraku, Kyoko Ishida, Asuka Takeyama, Fumihiko Yagi, Goji Tomita
[This corrects the article DOI: 10.1155/2015/186249.].
2015: Journal of Ophthalmology
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