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https://www.readbyqxmd.com/read/28319405/heptacene-characterization-in-solution-in-the-solid-state-and-in-films
#1
Ralf Einholz, Treliant Fang, Robert Berger, Peter Grüninger, Andreas Früh, Thomas Chassé, Reinhold F Fink, Holger F Bettinger
Acenes comprise an important class of organic semiconducting materials. As graphene nanoribbons of ultimate width, they are valuable atom-precise model systems for studying the properties of this form of nanoscale carbon materials. Heptacene is the smallest member of the acene series that could only be studied under matrix isolation conditions. Its existence in bulk had never been positively confirmed, despite efforts dating back more than 70 years. We report that the reduction of 7,16-heptacenequinone produces a mixture of two diheptacene molecules...
March 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28306549/magic-angle-spinning-nmr-study-of-the-ferroelectric-transition-of-kh2po4-definitive-evidence-of-a-displacive-component
#2
Jin Jung Kweon, Riqiang Fu, Eun Sang Choi, Naresh S Dalal
Variable temperature magic angle spinning (MAS) NMR measurements are reported on (1)H and (31)P nuclei in KH2PO4 (KDP) in the vicinity of its paraelectric-ferroelectric phase transition temperature, T c, of 123 K, to examine the transition mechanism, in particular if this is a model order-disorder type or whether it also involves a displacive component. It has been well established that the temperature variation of the isotropic chemical shift, δ iso, in NMR measurements of the nuclei directly involved in the transition should remain constant or change smoothly through T c for an order-disorder type transition but it should show an anomalous change for a displacive one...
March 17, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28306308/application-of-a-resource-theory-for-magic-states-to-fault-tolerant-quantum-computing
#3
Mark Howard, Earl Campbell
Motivated by their necessity for most fault-tolerant quantum computation schemes, we formulate a resource theory for magic states. First, we show that robustness of magic is a well-behaved magic monotone that operationally quantifies the classical simulation overhead for a Gottesman-Knill-type scheme using ancillary magic states. Our framework subsequently finds immediate application in the task of synthesizing non-Clifford gates using magic states. When magic states are interspersed with Clifford gates, Pauli measurements, and stabilizer ancillas-the most general synthesis scenario-then the class of synthesizable unitaries is hard to characterize...
March 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28306272/electromagnetic-moments-of-radioactive-136-te-and-the-emergence-of-collectivity-2p%C3%A2-2n-outside-of-double-magic-132-sn
#4
J M Allmond, A E Stuchbery, C Baktash, A Gargano, A Galindo-Uribarri, D C Radford, C R Bingham, B A Brown, L Coraggio, A Covello, M Danchev, C J Gross, P A Hausladen, N Itaco, K Lagergren, E Padilla-Rodal, J Pavan, M A Riley, N J Stone, D W Stracener, R L Varner, C-H Yu
Radioactive ^{136}Te has two valence protons and two valence neutrons outside of the ^{132}Sn double shell closure, providing a simple laboratory for exploring the emergence of collectivity and nucleon-nucleon interactions. Coulomb excitation of ^{136}Te on a titanium target was utilized to determine an extensive set of electromagnetic moments for the three lowest-lying states, including B(E2;0_{1}^{+}→2_{1}^{+}), Q(2_{1}^{+}), and g(2_{1}^{+}). The results indicate that the first-excited state, 2_{1}^{+}, composed of the simple 2p⊕2n system, is prolate deformed, and its wave function is dominated by excited valence neutron configurations, but not to the extent previously suggested...
March 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28303963/structural-analysis-of-human-cofilin-2-filamentous-actin-assemblies-atomic-resolution-insights-from-magic-angle-spinning-nmr-spectroscopy
#5
Jenna Yehl, Elena Kudryashova, Emil Reisler, Dmitri Kudryashov, Tatyana Polenova
Cellular actin dynamics is an essential element of numerous cellular processes, such as cell motility, cell division and endocytosis. Actin's involvement in these processes is mediated by many actin-binding proteins, among which the cofilin family plays unique and essential role in accelerating actin treadmilling in filamentous actin (F-actin) in a nucleotide-state dependent manner. Cofilin preferentially interacts with older filaments by recognizing time-dependent changes in F-actin structure associated with the hydrolysis of ATP and release of inorganic phosphate (Pi) from the nucleotide cleft of actin...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28301071/applications-of-high-resolution-magic-angle-spinning-mrs-in-biomedical-studies-i-cell-line-and-animal-models
#6
REVIEW
Eva Kaebisch, Taylor L Fuss, Lindsey A Vandergrift, Karin Toews, Piet Habbel, Leo L Cheng
High-resolution magic angle spinning (HRMAS) MRS allows for direct measurements of non-liquid tissue and cell specimens to present valuable insights into the cellular metabolisms of physiological and pathological processes. HRMAS produces high-resolution spectra comparable to those obtained from solutions of specimen extracts but without complex metabolite extraction processes, and preserves the tissue cellular structure in a form suitable for pathological examinations following spectroscopic analysis. The technique has been applied in a wide variety of biomedical and biochemical studies and become one of the major platforms of metabolomic studies...
March 16, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28299409/nothing-magical-pantomimed-grasping-is-controlled-by-the-ventral-system
#7
Thijs Rinsma, John van der Kamp, Matt Dicks, Rouwen Cañal-Bruland
In a recent amendment to the two-visual-system model, it has been proposed that actions must result in tactile contact with the goal object for the dorsal system to become engaged (Whitwell et al., Neuropsychologia 55:41-50, 2014). The present study tested this addition by assessing the use of allocentric information in normal and pantomime actions. To this end, magicians, and participants who were inexperienced in performing pantomime actions made normal and pantomime grasps toward objects embedded in the Müller-Lyer illusion...
March 15, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28298227/metabolomics-approaches-in-pancreatic-adenocarcinoma-tumor-metabolism-profiling-predicts-clinical-outcome-of-patients
#8
S Battini, F Faitot, A Imperiale, A E Cicek, C Heimburger, G Averous, P Bachellier, I J Namer
BACKGROUND: Pancreatic adenocarcinomas (PAs) have very poor prognoses even when surgery is possible. Currently, there are no tissular biomarkers to predict long-term survival in patients with PA. The aims of this study were to (1) describe the metabolome of pancreatic parenchyma (PP) and PA, (2) determine the impact of neoadjuvant chemotherapy on PP and PA, and (3) find tissue metabolic biomarkers associated with long-term survivors, using metabolomics analysis. METHODS: (1)H high-resolution magic angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy using intact tissues was applied to analyze metabolites in PP tissue samples (n = 17) and intact tumor samples (n = 106), obtained from 106 patients undergoing surgical resection for PA...
March 16, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28298111/-1-h-2-h-cross-polarization-nmr-in-fast-spinning-solids-by-adiabatic-sweeps
#9
Sungsool Wi, Robert Schurko, Lucio Frydman
Cross-polarization (CP) experiments employing frequency-swept radiofrequency (rf) pulses have been successfully used in static spin systems for obtaining broadband signal enhancements. These experiments have been recently extended to heteronuclear I, S = spin-1/2 nuclides under magic-angle spinning (MAS), by applying adiabatic inversion pulses along the S (low-γ) channel while simultaneously applying a conventional spin-locking pulse on the I-channel ((1)H). This study explores an extension of this adiabatic frequency sweep concept to quadrupolar nuclei, focusing on CP from (1)H (I = 1/2) to (2)H spins (S = 1) undergoing fast MAS (νr = 60 kHz)...
March 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28293122/toxicant-associated-steatohepatitis-%C3%A3-propos-a-case-of-benzene-exposure
#10
Daniel Benharroch, Boris Talalay
An attempted interpretation of recurrent episodes of hepatitis in a girl at ages 6 and 13 years, which were followed by an interval of 35 years of apparent good health, is reported. A subsequent transient incidence of a halothane hypersensitivity reaction at age 48 years led to the disclosure of negative hepatitis A, B and C antigenicity. A tentative diagnosis may be reached if we accept, at its face value, the statement that a toy that the child played with before each hepatitis episode carried a very high benzene content...
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28290700/metabolic-response-to-everolimus-in-patient-derived-triple-negative-breast-cancer-xenografts
#11
Leslie R Euceda, Deborah K Hill, Endre Stokke, Rana Hatem, Rania El Botty, Ivan Bièche, Elisabetta Marangoni, Tone F Bathen, Siver A Moestue
Patients with triple negative breast cancer (TNBC) are unresponsive to endocrine and anti-HER2 pharmacotherapy, limiting their therapeutic options to chemotherapy. TNBC is frequently associated with abnormalities in the PI3K/AKT/mTOR signaling pathway; drugs targeting this pathway are currently being evaluated in these patients. However, response is variable, partly due to heterogeneity within TNBC, conferring a need to identify biomarkers predicting response and resistance to targeted therapy. In this study, we used a metabolomics approach to assess response to the mTOR inhibitor everolimus in a panel of TNBC patient-derived xenografts (PDX) (n=103 animals)...
March 14, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28286989/a-precision-medicine-initiative-for-alzheimer-s-disease-the-road-ahead-to-biomarker-guided-integrative-disease-modeling
#12
H Hampel, S E O'Bryant, S Durrleman, E Younesi, K Rojkova, V Escott-Price, J-C Corvol, K Broich, B Dubois, S Lista
After intense scientific exploration and more than a decade of failed trials, Alzheimer's disease (AD) remains a fatal global epidemic. A traditional research and drug development paradigm continues to target heterogeneous late-stage clinically phenotyped patients with single 'magic bullet' drugs. Here, we propose that it is time for a paradigm shift towards the implementation of precision medicine (PM) for enhanced risk screening, detection, treatment, and prevention of AD. The overarching structure of how PM for AD can be achieved will be provided through the convergence of breakthrough technological advances, including big data science, systems biology, genomic sequencing, blood-based biomarkers, integrated disease modeling and P4 medicine...
April 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28285143/adiabatic-sweep-cross-polarization-magic-angle-spinning-nmr-of-half-integer-quadrupolar-spins
#13
Sungsool Wi, Chul Kim, Robert Schurko, Lucio Frydman
The use of frequency-swept radiofrequency (rf) pulses for enhancing signals in the magic-angle spinning (MAS) spectra of half-integer quadrupolar nuclides was explored. The broadband adiabatic inversion cross-polarization magic-angle spinning (BRAIN-CPMAS) method, involving an adiabatic inversion pulse on the S-channel and a simultaneous rectangular spin-lock pulse on the I-channel ((1)H), was applied to I(1/2)→S(3/2) systems. Optimal BRAIN-CPMAS matching conditions were found to involve low rf pulse strengths for both the I- and S-spin channels...
March 2, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28277547/backbone-assignment-of-perdeuterated-proteins-by-solid-state-nmr-using-proton-detection-and-ultrafast-magic-angle-spinning
#14
Pascal Fricke, Veniamin Chevelkov, Maximilian Zinke, Karin Giller, Stefan Becker, Adam Lange
Solid-state NMR (ssNMR) is a technique that allows the study of protein structure and dynamics at atomic detail. In contrast to X-ray crystallography and cryo-electron microscopy, proteins can be studied under physiological conditions-for example, in a lipid bilayer and at room temperature (0-35 °C). However, ssNMR requires considerable amounts (milligram quantities) of isotopically labeled samples. In recent years, (1)H-detection of perdeuterated protein samples has been proposed as a method of alleviating the sensitivity issue...
April 2017: Nature Protocols
https://www.readbyqxmd.com/read/28276825/perioperative-chemotherapy-for-resectable-gastric-cancer-what-is-the-evidence
#15
Erling A Bringeland, Hans H Wasmuth, Jon E Grønbech
The UK MAGIC trial published in 2006 was the first RCT to identify improved long-term survival rates using preoperative chemotherapy for resectable gastric or gastroesophageal cancer. Overnight, the treatment regimen impacted European guidelines. However, the majority of patients underwent limited lymph node dissection, and analyses of the rates of curative resection, downsizing and downstaging were not by intention to treat, rightfully raising concerns about their validity. For the subset of true gastric cancers, meta-analyses may even question the claims of improved long-term survival rates by present-day regimens...
February 28, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28276683/main-group-semiconductor-cluster-molecules-as-synthetic-intermediates-to-nanostructures
#16
Max R Friedfeld, Jennifer L Stein, Brandi M Cossairt
Main-group-semiconductor clusters are attractive atomically precise precursors for materials design. In particular, magic-sized clusters, those with elevated thermodynamic stability relative to other clusters of similar size, have been implicated as important intermediates in the synthesis of semiconductor nanostructures. A survey of the literature on the intermediacy of clusters in nanomaterial synthesis reveals two predominant mechanistic trends: monomer-driven growth and cluster assembly. In this Forum Article, we compare and contrast the systems in which these mechanisms are operative and attempt to extract the emerging design principles governing these transformations...
March 9, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28276097/-opening-remarks-at-a-practical-seminary-by-james-strachey
#17
Phillida B Rosnick
This manuscript, dated 1941, is a class on technique taught by James Strachey to first-year candidates at the British Psychoanalytical Society (BPS), located in the Archives of BPS. As the last of three written manuscripts on transference interpretation, it offers an opportunity to trace the development and subtle shift in Strachey's thinking following his 1934 paper (Strachey, , ). The lecture is striking in its precise language, and in the complexity of the issues discussed. Through the use of an optical metaphor, the magic lantern, Strachey illustrates transference, what is therapeutic about a transference interpretation and describes projective identification and some aspects of counter-transference without naming them as such...
March 9, 2017: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/28273309/much-more-than-movie-magic-dermatologic-applications-of-medical-moulage
#18
Alejandro Rabionet, Nishit Patel
No abstract text is available yet for this article.
March 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28266892/inflammatory-and-metalloproteinases-profiles-predict-three-month-poor-outcomes-in-ischemic-stroke-treated-with-thrombolysis
#19
Anna Maria Gori, Betti Giusti, Benedetta Piccardi, Patrizia Nencini, Vanessa Palumbo, Mascia Nesi, Antonia Nucera, Giovanni Pracucci, Paolina Tonelli, Eleonora Innocenti, Alice Sereni, Elena Sticchi, Danilo Toni, Paolo Bovi, Mario Guidotti, Maria Rosaria Tola, Domenico Consoli, Giuseppe Micieli, Rossana Tassi, Giovanni Orlandi, Maria Sessa, Francesco Perini, Maria Luisa Delodovici, Maria Luisa Zedde, Francesca Massaro, Rosanna Abbate, Domenico Inzitari
Inflammatory mediators and metalloproteinases are altered in acute ischemic stroke (AIS) and play a detrimental effect on clinical severity and hemorrhagic transformation of the ischemic brain lesion. Using data from the Italian multicenter observational MAGIC (MArker bioloGici nell'Ictus Cerebrale) Study, we evaluated the effect of inflammatory and metalloproteinases profiles on three-month functional outcome, hemorrhagic transformation and mortality in 327 patients with AIS treated with intravenous thrombolys in according to SITS-MOST (Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy) criteria...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28262871/from-single-atoms-to-self-assembled-quantum-single-atomic-nanowires-noble-metal-atoms-on-black-phosphorene-monolayers
#20
X J Zhao, Wen-Wen Shan, Hao He, Xinlian Xue, Z X Guo, S F Li
Transition metal (TM) nanostructures, such as one dimensional (1D) nanowires with/without substrates, usually possess drastically different properties from their bulk counterparts, due to their distinct stacking and electronic confinement. Correspondingly, it is of great importance to establish the dominant driving force in forming 1D single-metal-atom-wires (SMAWs). Here, with first-principles calculations, taking the black phosphorene (BP) monolayer as a prototype 2D substrate, we investigate the energetic and kinetic properties of all the 5d-TM atoms on the 2D substrate to reveal the mechanism of formation of SMAWs...
March 6, 2017: Physical Chemistry Chemical Physics: PCCP
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