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https://www.readbyqxmd.com/read/28107423/characterization-of-the-drug-resistance-profiles-of-patients-infected-with-crf07_bc-using-phenotypic-assay-and-ultra-deep-pyrosequencing
#1
Szu-Wei Huang, Wei-You Li, Wen-Hung Wang, Yu-Ting Lin, Chih-Hung Chou, Marcelo Chen, Hsien-Da Huang, Yen-Hsu Chen, Po-Liang Lu, Sheng-Fan Wang, Shinichi Oka, Yi-Ming Arthur Chen
The usefulness of ultra-deep pyrosequencing (UDPS) for the diagnosis of HIV-1 drug resistance (DR) remains to be determined. Previously, we reported an explosive outbreak of HIV-1 circulating recombinant form (CRF) 07_BC among injection drug users (IDUs) in Taiwan in 2004. The goal of this study was to characterize the DR of CRF07_BC strains using different assays including UDPS. Seven CRF07_BC isolates including 4 from early epidemic (collected in 2004-2005) and 3 from late epidemic (collected in 2008) were obtained from treatment-naïve patient's peripheral blood mononuclear cells...
2017: PloS One
https://www.readbyqxmd.com/read/28106417/chaos-and-regularity-in-the-doubly-magic-nucleus-208-pb
#2
B Dietz, A Heusler, K H Maier, A Richter, B A Brown
High-resolution experiments have recently lead to a complete identification (energy, spin, and parity) of 151 nuclear levels up to an excitation energy of E_{x}=6.20  MeV in ^{208}Pb [Heusler et al., Phys. Rev. C 93, 054321 (2016)PRVCAN2469-998510.1103/PhysRevC.93.054321]. We present a thorough study of the fluctuation properties in the energy spectra of the unprecedented set of nuclear bound states. In a first approach, we group states with the same spin and parity into 14 subspectra, analyze standard statistical measures for short- and long-range correlations, i...
January 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28099024/surface-interactions-and-confinement-of-methane-a-high-pressure-magic-angle-spinning-nmr-and-computational-chemistry-study
#3
Salim Ok, David W Hoyt, Amity Andersen, Julie Sheets, Susan A Welch, David R Cole, Karl Todd Mueller, Nancy M Washton
Characterization and modeling of the molecular-level behavior of simple hydrocarbon gases, such as methane, in the presence of both nonporous and nano-porous mineral matrices allows for predictive understanding of important processes in engineered and natural systems. In this study, changes in local electromagnetic environments of the carbon atoms in methane under conditions of high pressure (up to 130 bar) and moderate temperature (up to 346 K) were observed with 13C magic-angle spinning (MAS) NMR spectroscopy while the methane gas was mixed with two model solid substrates: a fumed non-porous, 12 nm particle size silica and a mesoporous silica with 200 nm particle size and 4 nm average pore diameter...
January 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28095721/a-lateral-dynamics-of-a-wheelchair-identification-and-analysis-of-tire-parameters
#4
L C A Silva, F C Corrêa, J J Eckert, F M Santiciolli, F G Dedini
In vehicle dynamics studies, the tire behaviour plays an important role in planar motion of the vehicle. Therefore, a correct representation of tire is a necessity. This paper describes a mathematical model for wheelchair tire based on the Magic Formula model. This model is widely used to represent forces and moments between the tire and the ground; however some experimental parameters must be determined. The purpose of this work is to identify the tire parameters for the wheelchair tire model, implementing them in a dynamic model of the wheelchair...
February 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/28093594/fast-and-accurate-mas-dnp-simulations-of-large-spin-ensembles
#5
Frédéric Mentink-Vigier, Shimon Vega, Gaël De Paëpe
A deeper understanding of parameters affecting Magic Angle Spinning Dynamic Nuclear Polarization (MAS-DNP), an emerging nuclear magnetic resonance hyperpolarization method, is crucial for the development of new polarizing agents and the successful implementation of the technique at higher magnetic fields (>10 T). Such progress is currently impeded by computational limitation which prevents the simulation of large spin ensembles (electron as well as nuclear spins) and to accurately describe the interplay between all the multiple key parameters at play...
January 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28093096/structural-biology-of-supramolecular-assemblies-by-magic-angle-spinning-nmr-spectroscopy
#6
Caitlin M Quinn, Tatyana Polenova
In recent years, exciting developments in instrument technology and experimental methodology have advanced the field of magic-angle spinning (MAS) nuclear magnetic resonance (NMR) to new heights. Contemporary MAS NMR yields atomic-level insights into structure and dynamics of an astounding range of biological systems, many of which cannot be studied by other methods. With the advent of fast MAS, proton detection, and novel pulse sequences, large supramolecular assemblies, such as cytoskeletal proteins and intact viruses, are now accessible for detailed analysis...
January 2017: Quarterly Reviews of Biophysics
https://www.readbyqxmd.com/read/28089491/satellite-and-central-transitions-selective-1-h-27-al-d-hmqc-experiments-at-very-fast-mas-for-quadrupolar-couplings-determination
#7
Nghia Tuan Duong, Yusuke Nishiyama
Recent study has demonstrated the application of the proton-detected heteronuclear multi-quantum coherence (HMQC) at ultrafast Magic Angle Spinning (MAS) to probe quadrupolar nuclei including (14)N and (35)Cl. In addition, for half-integer quadrupolar nucleus like (35)Cl, the quadrupolar product can be calculated based on the shift difference between the center band of satellite transition (ST) and the central transition (CT) peaks. The applicability of this technique is further investigated on spin I=5/2, namely (27)Al nucleus, and kaolin is chosen as the testing sample...
January 4, 2017: Solid State Nuclear Magnetic Resonance
https://www.readbyqxmd.com/read/28074670/metabolism-of-psilocybin-and-psilocin-clinical-and-forensic-toxicological-relevance
#8
Ricardo Jorge Dinis-Oliveira
Psilocybin and psilocin are controlled substances in many countries. These are the two main hallucinogenic compounds of the "magic mushrooms" and both act as agonists or partial agonists at 5-hydroxytryptamine (5-HT)2A subtype receptors. During the last few years, psilocybin and psilocin have gained therapeutic relevance but considerable physiological variability between individuals that can influence dose-response and toxicological profile has been reported. This review aims to discuss metabolism of psilocybin and psilocin, by presenting all major and minor psychoactive metabolites...
January 11, 2017: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/28074361/partially-deuterated-samples-of-het-s-218-289-fibrils-assignment-and-deuterium-isotope-effect
#9
Albert A Smith, Francesco Ravotti, Emilie Testori, Riccardo Cadalbert, Matthias Ernst, Anja Böckmann, Beat H Meier
Fast magic-angle spinning and partial sample deuteration allows direct detection of (1)H in solid-state NMR, yielding significant gains in mass sensitivity. In order to further analyze the spectra, (1)H detection requires assignment of the (1)H resonances. In this work, resonance assignments of backbone H(N) and Hα are presented for HET-s(218-289) fibrils, based on the existing assignment of Cα, Cβ, C', and N resonances. The samples used are partially deuterated for higher spectral resolution, and the shifts in resonance frequencies of Cα and Cβ due to the deuterium isotope effect are investigated...
January 10, 2017: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/28073329/the-other-side-of-magic
#10
Vebjørn Ekroll, Bilge Sayim, Johan Wagemans
When magicians perform spectacles that seem to defy the laws of nature, they do so by manipulating psychological reality. Hence, the principles underlying the art of conjuring are potentially of interest to psychological science. Here, we argue that perceptual and cognitive principles governing how humans experience hidden things and reason about them play a central role in many magic tricks. Different from tricks based on many other forms of misdirection, which require considerable skill on the part of the magician, many elements of these tricks are essentially self-working because they rely on automatic perceptual and cognitive processes...
January 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/28073068/comparative-analysis-of-isotropic-diffusion-weighted-imaging-sequences
#11
Sebastian Vellmer, Rüdiger Stirnberg, Daniel Edelhoff, Dieter Suter, Tony Stöcker, Ivan I Maximov
Visualisation of living tissue structure and function is a challenging problem of modern imaging techniques. Diffusion MRI allows one to probe in vivo structures on a micrometer scale. However, conventional diffusion measurements are time-consuming procedures, because they require several measurements with different gradient directions. Considerable time savings are therefore possible by measurement schemes that generate an isotropic diffusion weighting in a single shot. Multiple approaches for generating isotropic diffusion weighting are known and have become very popular as useful tools in clinical research...
December 30, 2016: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28066574/dexmedetomidine-magic-bullet-or-firing-blanks
#12
EDITORIAL
Daniel Sellers, George Djaiani
No abstract text is available yet for this article.
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28064161/statistical-significance-versus-clinical-relevance
#13
REVIEW
Marieke H C van Rijn, Anneke Bech, Jean Bouyer, Jan A J G van den Brand
In March this year, the American Statistical Association (ASA) posted a statement on the correct use of P-values, in response to a growing concern that the P-value is commonly misused and misinterpreted. We aim to translate these warnings given by the ASA into a language more easily understood by clinicians and researchers without a deep background in statistics. Moreover, we intend to illustrate the limitations of P-values, even when used and interpreted correctly, and bring more attention to the clinical relevance of study findings using two recently reported studies as examples...
January 7, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28064071/enhanced-efficiency-of-solid-state-nmr-investigations-of-energy-materials-using-an-external-automatic-tuning-matching-eatm-robot
#14
Oliver Pecher, David M Halat, Jeongjae Lee, Zigeng Liu, Kent J Griffith, Marco Braun, Clare P Grey
We have developed and explored an external automatic tuning/matching (eATM) robot that can be attached to commercial and/or home-built magic angle spinning (MAS) or static nuclear magnetic resonance (NMR) probeheads. Complete synchronization and automation with Bruker and Tecmag spectrometers is ensured via transistor-transistor-logic (TTL) signals. The eATM robot enables an automated "on-the-fly" re-calibration of the radio frequency (rf) carrier frequency, which is beneficial whenever tuning/matching of the resonance circuit is required, e...
December 23, 2016: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28059506/local-and-global-dynamics-in-klebsiella-pneumoniae-outer-membrane-protein-a-in-lipid-bilayers-probed-at-atomic-resolution
#15
Olivier Saurel, Iordan Iordanov, Guillaume Nars, Pascal Demange, Tanguy Le Marchand, Loren B Andreas, Guido Pintacuda, Alain Milon
The role of membrane proteins in cellular mechanism strongly depends on their dynamics, and solid-state magic-angle spinning (MAS) nuclear magnetic resonance (NMR) is a unique method to exhaustively characterize motions of proteins in a lipid environment. Herein, we make use of advances in (1)H-detected MAS NMR to describe the dynamics of the membrane domain of the Outer membrane protein A of Klebsiella pneumoniae (KpOmpA). By measuring (1)H-(15)N dipolar-coupling as well as (15)N R1 and R1ρ relaxation rates at fast (60 kHz) MAS and high magnetic field (1 GHz), we were able to describe the motions of the residues of the β-barrel as a collective rocking of low amplitude and of hundreds of nanoseconds time scale...
January 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28057400/solid-state-17-o-nmr-study-of-2-acylbenzoic-acids-and-warfarin
#16
Xianqi Kong, Yizhe Dai, Gang Wu
We report synthesis and solid-state (17)O NMR characterization of four site-specifically (17)O-labeled 2-acylbenzoic acids (2-RC(O)C6H4COOH) where R=H and CH3): 2-[3-(17)O]formylbenzoic acid, 2-[1,2-(17)O2]formylbenzoic acid, 2-[3-(17)O]acetylbenzoic acid, and 2-[1,2,3-(17)O3]acetylbenzoic acid. In the solid state, both 2-formyl- and 2-acetyl-benzoic acids exist as the cyclic phthalide form each containing a five-membered lactone ring and a cyclic hemiacetal/hemiketal group. Static and magic-angle-spinning (17)O NMR spectra were recorded at 14...
December 27, 2016: Solid State Nuclear Magnetic Resonance
https://www.readbyqxmd.com/read/28057187/challenges-in-laboratory-detection-of-unusual-substance-abuse-issues-with-magic-mushroom-peyote-cactus-khat-and-solvent-abuse
#17
A Dasgupta
Drug abuse is a worldwide problem. Although commonly abused drugs can be identified during routine urine drug testing, less commonly abused drugs may escape detection. These less commonly abused drugs not only include some designer drugs such as synthetic cannabinoid but also include abuse of psychedelic magic mushroom (active ingredients: psilocybin and psilocin), peyote cactus (active ingredient: mescaline), and khat plants (active ingredient: cathinone). Moreover, solvent and glue abuse is gaining popularity among teenagers and young adults which may even cause fatality...
2017: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/28054675/oleylamine-as-a-reducing-agent-in-syntheses-of-magic-size-clusters-and-monodisperse-quantum-dots-optical-and-photoconductivity-studies
#18
R S Ningthoujam, Anurag Gautam, N Padma
Separation of magic size clusters (MSCs) from monodisperse quantum dots (QDs) has generally been a difficult task while employing the commonly used synthesis procedure, where for preparation of PbSe QDs, Se-TOP (TOP = trioctylphosphine) is injected into Pb-oleate in 1-octadecene medium. In this study, we report for the first time a simple method to prepare MSCs, QDs and particles close to the bulk of PbSe using oleylamine (OAM) as the reducing agent, where the individual entities are efficiently separated. The chemical yield is found to be 95%...
January 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28051782/replacing-magic-bullets-with-beneficial-pleiotropy-in-atherosclerosis
#19
Martin Bennett
No abstract text is available yet for this article.
November 11, 2016: Circulation Research
https://www.readbyqxmd.com/read/28051312/modification-of-tio2-nanoparticles-with-oleyl-phosphate-via-phase-transfer-in-the-toluene-water-system-and-application-of-modified-nanoparticles-to-cyclo-olefin-polymer-based-organic-inorganic-hybrid-films-exhibiting-high-refractive-indices
#20
Shiori Takahashi, Shuhei Hotta, Akira Watanabe, Naokazu Idota, Kimihiro Matsukawa, Yoshiyuki Sugahara
Oleyl-phosphate-modified TiO2 nanoparticles (OP_TiO2) were prepared via phase transfer from an aqueous phase containing dispersed TiO2 nanoparticles to a toluene phase containing oleyl phosphate (OP, a mixture of monoester and diester), and employed for the preparation of OP_TiO2/cyclo-olefin polymer (COP) hybrid films with high-refractive indices. The modification of TiO2 by OP was essentially completed by reaction at room temperature for 8 h, and essentially all the TiO2 nanoparticles in the aqueous phase were transferred to the toluene phase...
January 18, 2017: ACS Applied Materials & Interfaces
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