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https://www.readbyqxmd.com/read/28648865/self-assembled-amphiphilic-core-shell-nanocarriers-in-line-with-the-modern-strategies-for-brain-delivery
#1
REVIEW
Reham S Elezaby, Heba A Gad, Abdelkader A Metwally, Ahmed S Geneidi, Gehanne A Awad
Disorders of the central nervous system (CNS) represent increasing social and economic problems all over the world which makes the effective transport of drugs to the brain a crucial need. In the last decade, many strategies were introduced to deliver drugs to the brain trying to overcome the challenge of the blood brain barrier (BBB) using both invasive and non-invasive methods. Non-invasive strategy represented in the application of nanocarriers became very common. One of the most hopeful nanoscopic carriers for brain delivery is core-shell nanocarriers or polymeric micelles (PMs)...
June 22, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28648467/differentiating-could-from-should-developmental-changes-in-modal-cognition
#2
Andrew Shtulman, Jonathan Phillips
Young children have difficulty in distinguishing events that violate physical laws (impossible events) from those that violate mere physical regularities (improbable events). They judge both as "impossible." Young children also have difficulty in distinguishing events that violate moral laws (immoral events) from events that violate mere social regularities (unconventional events). They judge both as "wrong." In this set of studies, we explored the possibility that both difficulties arise from a more general deficit in modal cognition, or the way in which children represent and reason about possibilities...
June 22, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28646299/effective-combined-water-and-sideband-suppression-for-low-speed-tissue-and-in-vivo-mas-nmr
#3
Yalda Liaghati Mobarhan, Jochem Struppe, Blythe Fortier-McGill, André J Simpson
High-resolution magic angle spinning (HR-MAS) NMR is a powerful technique that can provide metabolic profiles and structural constraints on intact biological and environmental samples such as cells, tissues and living organisms. However, centripetal force from fast spinning can lead to a loss of sample integrity. In analyses focusing on structural organization, metabolite compartmentalization or in vivo studies, it is critical to keep the sample intact. As such, there is growing interest in slow spinning studies that preserve sample longevity...
June 23, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28646173/transmembrane-interactions-of-full-length-mammalian-bitopic-cytochrome-p450-cytochrome-b5-complex-in-lipid-bilayers-revealed-by-sensitivity-enhanced-dynamic-nuclear-polarization-solid-state-nmr-spectroscopy
#4
Kazutoshi Yamamoto, Marc A Caporini, Sang-Choul Im, Lucy Waskell, Ayyalusamy Ramamoorthy
The dynamic protein-protein and protein-ligand interactions of integral bitopic membrane proteins with a single membrane-spanning helix play a plethora of vital roles in the cellular processes associated with human health and diseases, including signaling and enzymatic catalysis. While an increasing number of high-resolution structural studies of membrane proteins have successfully manifested an in-depth understanding of their biological functions, intact membrane-bound bitopic protein-protein complexes pose tremendous challenges for structural studies by crystallography or solution NMR spectroscopy...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28645983/the-effect-of-magnesium-supplementation-on-vascular-calcification-in-chronic-kidney-disease-a-randomised-clinical-trial-magical-ckd-essential-study-design-and-rationale
#5
Iain Bressendorff, Ditte Hansen, Morten Schou, Charlotte Kragelund, Lisbet Brandi
INTRODUCTION: Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease and mortality, which is thought to be caused by increased propensity towards vascular calcification (VC). Magnesium (Mg) inhibits phosphate-induced VC in vitro and in animal models and serum Mg is inversely associated with cardiovascular mortality in predialysis CKD and in end-stage renal disease. This paper will describe the design and rationale of a randomised double-blinded placebo-controlled multicentre clinical trial, which will investigate whether oral Mg supplementation can prevent the progression of coronary artery calcification (CAC) in subjects with predialysis CKD...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28644583/a-slice-of-hospital-toast-a-day-keeps-the-doctors-at-bay
#6
S Martin, C Hill
Anecdotal evidence over the years has suggested that toast made in hospital, so called 'hospital toast' tastes better than toast made at home, or anywhere else for that matter. We carried out a prospective, multi-professional study to determine the views and the toast eating habits of NHS staff. Fifty members of NHS staff were surveyed across two hospital trusts. This included nursing staff, doctors from various specialties and allied health professionals. Results were overwhelming, a staggering 96% admitted to enjoying a slice of hospital toast while at work...
December 12, 2016: Irish Medical Journal
https://www.readbyqxmd.com/read/28639483/assessing-narcissism-using-rorschach-based-imagery-and-behavior-validated-by-clinician-reports-studies-with-adult-patients-and-nonpatients
#7
Emanuela S Gritti, David P Marino, Margherita Lang, Gregory J Meyer
We evaluate 11 Rorschach variables with potential for assessing grandiosity and narcissism. Seven of these variables were drawn from previous literature: Omnipotence, Idealization, Reflection, Personal Knowledge Justification, Exhibitionism, Magic, and Elevated Mood States; four were developed for this research: Expanded Personal Reference, Narcissistic Devaluation, Narcissistic Deflation, and Narcissistic Denial. Using Rorschach protocols from American normative adults and Italian adult outpatients, the dimensional structure of these variables was evaluated by principal components analysis, and validity was tested by correlations with clinician ratings of narcissism on two scales from the Shedler-Westen Assessment Procedure-200 that were made after at least five sessions with the primary clinician...
June 1, 2017: Assessment
https://www.readbyqxmd.com/read/28638485/psma-pet-for-lymph-node-detection-in-recurrent-prostate-cancer-how-do-we-use-the-magic-bullet
#8
EDITORIAL
Tobias Maurer, Declan G Murphy, Michael S Hofman, Matthias Eiber
No abstract text is available yet for this article.
2017: Theranostics
https://www.readbyqxmd.com/read/28637015/differential-metabonomic-profiles-of-primary-hepatocellular-carcinoma-tumors-from-alcoholic-liver-disease-hbv-infected-and-hcv-infected-cirrhotic-patients
#9
Ding Cao, Can Cai, Mingxin Ye, Junhua Gong, Menghao Wang, Jinzheng Li, Jianping Gong
Our objective was to comparatively profile the metabolite composition of primary hepatocellular carcinoma (HCC) tumors from alcoholic liver disease (ALD), hepatitis B virus (HBV)-infected, and hepatitis C virus (HCV)-infected cirrhotic patients. Primary HCC tumors were collected from ALD, HBV-infected, and HCV-infected cirrhotic patients (n=20 each). High-resolution magic-angle spinning proton nuclear magnetic resonance spectroscopy and metabonomic data analysis were performed to compare HCC tumors from the three groups...
June 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28631954/parameter-setting-in-the-acquisition-of-consonant-clusters-by-phonologically-delayed-children
#10
Liang Chen, Ning Pan
The relationship between the acquisition of initial complex onset clusters, /s/-initial clusters, and non-initial clusters is much studied yet poorly understood. Pan and Snyder (2004), working within the Government Phonology (GP) framework, proposed that the production of the three types of consonant clusters requires the proper setting of three binary parameters [+/- Branching onset (BO), [+/-Branching rhyme (BR)] and [+/-Magic empty nucleus (MEN)]. Specifically, the production of onset clusters require [+BO], /s/-initial clusters require both [+BR] and [+MEN], and non-initial clusters require [+BR]...
February 16, 2017: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/28625305/decision-to-delivery-interval-is-30%C3%A2-min-the-magic-time-what-is-the-evidence-does-it-work
#11
REVIEW
J H Tomlinson, D N Lucas
Emergency caesarean section is required when delivery can reduce the risk to the life of the mother or foetus. When a caesarean section is indicated for foetal compromise, a decision-to-delivery interval of 30 min (or less) has been suggested as the ideal time frame within which an obstetric team should achieve delivery. In theory, a short decision-to-delivery interval may minimise intra-uterine hypoxia and improve neonatal outcome. Current medical evidence does not support this time frame. There are certain indications for caesarean section that necessitate a much shorter decision-to-delivery interval, but evidence suggests that the majority of neonates may be safely delivered within a longer interval of time...
March 2017: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/28623034/new-nmr-tools-for-protein-structure-and-function-spin-tags-for-dynamic-nuclear-polarization-solid-state-nmr
#12
Rivkah Rogawski, Ann McDermott
Magic angle spinning solid state NMR studies of biological macromolecules [1-3] have enabled exciting studies of membrane proteins [4,5], amyloid fibrils [6], viruses, and large macromolecular assemblies [7]. Dynamic nuclear polarization (DNP) provides a means to enhance detection sensitivity for NMR, particularly for solid state NMR, with many recent biological applications and considerable contemporary efforts towards elaboration and optimization of the DNP experiment. This review explores precedents and innovations in biological DNP experiments, especially highlighting novel chemical biology approaches to introduce the radicals that serve as a source of polarization in the DNP experiments...
June 13, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28619057/polysaccharide-compositions-of-collenchyma-cell-walls-from-celery-apium-graveolens-l-petioles
#13
Da Chen, Philip J Harris, Ian M Sims, Zoran Zujovic, Laurence D Melton
BACKGROUND: Collenchyma serves as a mechanical support tissue for many herbaceous plants. Previous work based on solid-state NMR and immunomicroscopy suggested collenchyma cell walls (CWs) may have similar polysaccharide compositions to those commonly found in eudicotyledon parenchyma walls, but no detailed chemical analysis was available. In this study, compositions and structures of cell wall polysaccharides of peripheral collenchyma from celery petioles were investigated. RESULTS: This is the first detailed investigation of the cell wall composition of collenchyma from any plant...
June 15, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28619033/social-representations-of-malaria-in-the-guna-indigenous-population-of-comarca-guna-de-madungandi-panama
#14
Lorenzo Cáceres, José E Calzada, Amanda Gabster, Josue Young, Ricardo Márquez, Rolando Torres, Margarita Griffith
BACKGROUND: The purpose of the study was to recognize the social representation of the Guna indigenous population by identifying cultural elements related to malaria, in order to create an intercultural approach to any health intervention to control and prevent the disease. METHODS: This qualitative study has an anthropological focus that used participant observation, informal conversations, focus groups, interviews, in-depth interviews with key actors. Analyses included review, classification and categorization of interviews...
June 15, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28618387/two-pulse-recoupling
#15
Navin Khaneja, Ashutosh Kumar
The paper describes a family of novel recoupling pulse sequences in magic angle spinning (MAS) solid state NMR, called two pulse recoupling. These pulse sequences can be employed for both homonuclear and heteronuclear recoupling experiments and are robust to dispersion in chemical shifts and rf-inhomogeneity. The homonuclear pulse sequence consists of a building block (π)ϕ(π)-ϕ where ϕ=π4n, and n is number of blocks in a rotor period. The recoupling block is made robust to rf-inhomogeneity by extending it to (π)ϕ(π)-ϕ(π)π+ϕ(π)π-ϕ...
June 12, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28616749/mir-183-and-mir-21-expression-as-biomarkers-of-progression-and-survival-in-tongue-carcinoma-patients
#16
Gordana Supic, Katarina Zeljic, Aleksandra Divac Rankov, Ruzica Kozomara, Aleksandra Nikolic, Dragica Radojkovic, Zvonko Magic
OBJECTIVES: Micro RNAs (miRNAs) have a major role in human cancerogenesis.The current study investigated the prognostic significance of miR-183 and miR-21 expression in tongue carcinoma patients. MATERIAL AND METHOD: For qPCR of miR-183 and miR-21 expression, total RNA isolated from 60 fresh-frozen tissue of tongue carcinomas was converted into cDNA by TaqMan MicroRNA Reverse Transcription Kit and quantified by TaqMan MicroRNAs Expression Assays. Fold changes in the miRNAs expression, normalized to RNU6B, were determined using 2(-ΔΔCt) method, and dichotomized into high and low according to cut-off values derived from ROC curve analysis...
June 14, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28610515/money-tree-for-some%C3%A2
#17
Jackie
The Conservative party says there is no magic tree for public sector workers, so why is there a money tree for MPs and tax cuts for corporations and high earners? We have lost the bursary, and students will have to pay for their training. If pay stays the way it is, there will be consequences for the profession and the NHS. School leavers and mature students will not train to do a job that leaves them in debit and poor.
June 14, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28609341/magic-mirror-on-the-wall-which-is-the-right-study-design-of-them-all-part-ii
#18
Thomas R Vetter
The assessment of a new or existing treatment or other intervention typically answers 1 of 3 central research-related questions: (1) "Can it work?" (efficacy); (2) "Does it work?" (effectiveness); or (3) "Is it worth it?" (efficiency or cost-effectiveness). There are a number of study designs that, on a situational basis, are appropriate to apply in conducting research. These study designs are generally classified as experimental, quasiexperimental, or observational, with observational studies being further divided into descriptive and analytic categories...
July 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28606720/the-magical-revolution
#19
REVIEW
Molly S Laas
No abstract text is available yet for this article.
June 9, 2017: Endeavour
https://www.readbyqxmd.com/read/28604490/health-related-quality-of-life-in-early-onset-scoliosis-patients-treated-surgically-eosq-scores-in-traditional-growing-rod-vs-magnetically-controlled-growing-rods
#20
Michael E Doany, Z Deniz Olgun, Gizem Irem Kinikli, Senol Bekmez, Aykut Kocyigit, Gokhan Demirkiran, A Ergun Karaagaoglu, Muharrem Yazici
STUDY DESIGN: Cross-sectional study. OBJECTIVE: To compare quality of life and caregiver burden in TGR and MCGR patients. SUMMARY OF BACKGROUND DATA: Magnetic controlled growing rods (MCGR) decrease surgical sessions associated with treatment of early onset scoliosis (EOS), hoping to minimize the burdens seen with repetitive invasive surgeries in traditional growing rod (TGR) treatment. Although the clinical indications for these treatments have largely been agreed upon, there is a lack of understanding of their impact on patients' and families' quality of life...
June 9, 2017: Spine
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