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https://www.readbyqxmd.com/read/28431222/principles-of-chemical-biology-from-magic-to-gut-fungi-via-plug-and-play-biosensors
#1
(no author information available yet)
This month: New MAGIC linking mitochondrial biology and proteostasis, split RNA polymerase based biosensors, and a role that fungi play in human gut microbiome.
April 20, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28429936/electron-decoupling-with-dynamic-nuclear-polarization-in-rotating-solids
#2
Edward P Saliba, Erika L Sesti, Faith J Scott, Brice J Albert, Eric J Choi, Nicholas Alaniva, Chukun Gao, Alexander B Barnes
Dynamic nuclear polarization (DNP) can enhance NMR sensitivity by orders of magnitude by transferring spin polarization from electron paramagnetic resonance (EPR) to NMR. However, paramagnetic DNP polarizing agents can have deleterious effects on NMR signals. Electron spin decoupling can mitigate these paramagnetic relaxation effects. We demonstrate electron decoupling experiments in conjunction with DNP and magic angle spinning (MAS) NMR spectroscopy. Following a DNP and spin diffusion period, the microwave irradiation frequency is quickly tuned on-resonance with electrons on the DNP polarizing agent...
April 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28426071/ca-and-sr-tetrafluoroisophthalates-mechanochemical-synthesis-characterization-and-ab-initio-structure-determination
#3
Abdal-Azim Al-Terkawi, Gudrun Scholz, Ana Guilherme Buzanich, Stefan Reinsch, Franziska Emmerling, Erhard Kemnitz
New fluorinated coordination polymers were prepared mechanochemically by milling the alkaline earth metal hydroxides M(II)(OH)2·xH2O (M(II): Ca, Sr) with tetrafluoroisophthalic acid (H2mBDC-F4). The structures of [{Ca(mBDC-F4)(H2O)2}·H2O] (1) and [{Sr(mBDC-F4)(H2O)2}·H2O] (2) were determined based on ab initio calculations and their powder X-ray diffraction (PXRD) data. The compounds are isomorphous and crystallize in the orthorhombic space group P212121. The determined structures were validated by using extended X-ray absorption (EXAFS) data...
April 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28425554/on-the-parallelism-between-the-mechanisms-behind-chromatography-and-drug-delivery-the-role-of-interactions-with-a-stationary-phase
#4
Filippo Rossi, Franca Castiglione, Matteo Salvalaglio, Monica Ferro, Marta Moioli, Emanuele Mauri, Maurizio Masi, Andrea Mele
A huge number of studies and work in the drug delivery literature are focused on understanding and modeling transport phenomena, the pivotal point for a good device design. The rationalization of all phenomena involved is fundamental, but several concerns arise leaving many issues unsolved. In order to change the point of view we decided to focus our attention on the parallelisms between two fields that seem to be very far from each other: chromatography and drug release. Taking advantages of the studies conducted by many researchers using chromatographic columns we decided to explain all the phenomena involved in drug delivery considering sodium ibuprofen (IP) molecules as analytes and hydrogel as a stationary phase...
April 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28424705/contemporary-understanding-of-mirna-based-regulation-of-secondary-metabolites-biosynthesis-in-plants
#5
REVIEW
Om P Gupta, Suhas G Karkute, Sagar Banerjee, Nand L Meena, Anil Dahuja
Plant's secondary metabolites such as flavonoids, terpenoids, and alkaloids etc. are known for their role in the defense against various insects-pests of plants and for medicinal benefits in human. Due to the immense biological importance of these phytochemicals, understanding the regulation of their biosynthetic pathway is crucial. In the recent past, advancement in the molecular technologies has enabled us to better understand the proteins, enzymes, genes, etc. involved in the biosynthetic pathway of the secondary metabolites...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28424380/-schizotypy-detachment-or-magical-fusion
#6
János Kállai, Mária Simon, István Hartung, Béla Birkás, Róbert Herold
Nowadays, both in the clinical population, and in general communities, we tend to encounter an increasing number of personality disorder patients, whose social adjustment, partnerships and efficient life management is made difficult by the disorder. The ideas of borderline personality disorder patients, who fluctuate between farfetched expectations and fears of their selves being demolished, schizoid patients, who close their selves in their own alienating prison, avoidant patients, who try to escape difficulties, which would enhance their self-esteem, OCD patients, who build their own mythic superstitious world, and antisocial patients who tend to ignore and aggressively override others' interests are all important in the development of cultures with insecure identities...
2017: Psychiatria Hungarica: A Magyar Pszichiátriai Társaság Tudományos Folyóirata
https://www.readbyqxmd.com/read/28423212/persistent-radicals-of-self-assembled-benzophenone-bis-urea-macrocycles-characterization-and-application-as-a-polarizing-agent-for-solid-state-dnp-mas-spectroscopy
#7
Baillie A DeHaven, John T Tokarski, Arthur A Korous, Frederic Mentink-Vigier, Thomas M Makris, Alexander M Brugh, Malcolm D E Forbes, Johan van Tol, Clifford Russ Bowers, Linda S Shimizu
UV-irradiation of a self-assembled benzophenone bis-urea macrocycle generates μM amounts of radicals that persist for weeks under ambient conditions. High-Field EPR and variable temperature X-band EPR studies suggest a resonance stabilized radical pair through H-abstraction. These endogenous radicals were applied as a polarizing agent for magic angle spinning (MAS) dynamic nuclear polarization (DNP) NMR enhancement. The field-stepped DNP enhancement profile exhibits a sharp peak with a maximum enhancement of εon/off = 4 superimposed on a nearly constant DNP enhancement of εon/off = 2 over a broad field range...
April 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28420639/implementing-shared-decision-making-in-the-nhs-lessons-from-the-magic-programme
#8
Natalie Joseph-Williams, Amy Lloyd, Adrian Edwards, Lynne Stobbart, David Tomson, Sheila Macphail, Carole Dodd, Kate Brain, Glyn Elwyn, Richard Thomson
No abstract text is available yet for this article.
April 18, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28413765/experimental-and-theoretical-examination-of-the-radical-cations-obtained-from-the-chemical-and-electrochemical-oxidation-of-5-aminothiazoles
#9
Kirara Yamaguchi, Toshiaki Murai, Shoichi Kutsumizu, Yohei Miwa, Masahiro Ebihara, Jing-Dong Guo, Norihiro Tokitoh
Chemical or electrochemical one-electron oxidation of 5-N-arylaminothiazoles was found to afford stable radical cations. For chemical oxidation, 1 equivalent of [(4-BrC6H4)3N][SbCl6] (Magic Blue, MB) was added to CH2Cl2 solutions of the thiazoles, and the thus-obtained radicals showed light absorption in the near-infrared region. Electrochemical oxidation also led to bathochromic shifts in the absorption bands, and the obtained spectra were similar to those derived from the chemically oxidized species. These radicals afforded electron paramagnetic resonance (EPR) spectra that are consistent with the notion of stable nitrogen radicals (half-life≤385 h)...
April 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28412463/frameworks-for-adaptation-of-health-guidelines-a-methodological-survey
#10
REVIEW
Andrea Darzi, Elias A Abou-Jaoude, Arnav Agarwal, Chantal Lakis, Wojtek Wiercioch, Nancy Santesso, Hneine Brax, Fadi El-Jardali, Holger J Schünemann, Elie A Akl
BACKGROUND: Our objective was to identify and describe published frameworks for adaptation of clinical, public health and health services guidelines. METHODS: We included reports describing methods of adaptation of guidelines in sufficient detail to allow its reproducibility. We searched Medline, and EMBASE databases. We also searched personal files, as well manuals and handbooks of organizations and professional societies that proposed methods of adaptation and adoption of guidelines...
April 12, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28406633/probing-the-conformationally-excited-states-of-membrane-proteins-via-1-h-detected-mas-solid-state-nmr-spectroscopy
#11
T Gopinath, Sarah E D Nelson, Kailey J Soller, Gianluigi Veglia
Proteins exist in ensembles of conformational states that interconvert on various motional time scales. High-energy states of proteins, often referred to as conformationally excited states, are sparsely populated and have been found to play an essential role in many biological functions. However, detecting these states is quite difficult for conventional structural techniques. Recent progress in solution NMR spectroscopy made it possible to detect conformationally excited states in soluble proteins and characterize them at high resolution...
April 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28406554/vitamin-d-receptor-gene-polymorphisms-association-with-the-risk-of-sepsis-and-mortality
#12
K Zeljic, A Elkilany, G Supic, M Surbatovic, D Djordjevic, Z Magic, B Bozic
Association of vitamin D receptor (VDR) gene polymorphisms with sepsis risk and mortality was studied. VDR FokI CC genotype was associated with increased sepsis risk (OR = 13.396, p = .000009) compared to the TT genotype. Results suggest possible role of VDR FokI (rs2228570) as a molecular biomarker of increased sepsis risk.
April 12, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28403609/solid-state-nmr-characterization-of-ibuprofen-nicotinamide-cocrystals-and-new-idea-for-controlling-release-of-drugs-embedded-into-mesoporous-silica-particles
#13
Ewa Skorupska, Sławomir Kaźmierski, Marek J Potrzebowski
Grinding and melting methods were employed for synthesis of pharmaceutical cocrystals formed by racemic (R/S) and entiomeric (S) ibuprofen (IBU) and nicotinamide (NA) as coformer. Obtained (R/S)-IBU:NA and (S)-IBU:NA cocrystals were fully characterized by means of advanced one- and two-dimensional solid state nuclear magnetic resonance (SS NMR) techniques with very fast magic angle spinning (MAS) at 60 kHz. The distinction in molecular packing and specific hydrogen bonding pattern was clearly recognized by analysis of (1)H, (13)C, and (15)N spectra...
April 18, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28396091/targeting-mitochondrial-dysfunction-in-cns-injury-using-methylene-blue-still-a-magic-bullet
#14
Hemendra J Vekaria, Lora Talley Watts, Ai-Ling Lin, Patrick G Sullivan
Complex, multi-factorial secondary injury cascades are initiated following traumatic brain injury, which makes this a difficult disease to treat. The secondary injury cascades following the primary mechanical tissue damage, are likely where effective therapeutic interventions may be targeted. One promising therapeutic target following brain injury are mitochondria. Mitochondria are complex organelles found within the cell, which act as powerhouses within all cells by supplying ATP. These organelles are also necessary for calcium cycling, redox signaling and play a major role in the initiation of cell death pathways...
April 7, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28394382/synergistic-effect-of-processing-additives-and-thermal-annealing-in-organic-solar-cells-the-morphology-of-magic
#15
Xunfan Liao, Ruizhi Lv, Lie Chen, Yiwang Chen
Organic solar cells (OSCs) usually need to be optimized with the strategies of thermal annealing (TA), solvent vapor annealing (SVA), or processing additives (PA) to obtain the best performance. Here, PA and TA were used simultaneously for OSCs based on the novel organic molecules TBDT-T6ffBT and OBDT-T6ffBT. The synergistic effect of PA and TA on the active-layer morphologies was investigated by measurements of optical microscopy, atomic force microscopy, transmission electron microscopy, and grazing incident X-ray diffraction...
April 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28394304/the-diet-and-haemodialysis-dyad-three-eras-four-open-questions-and-four-paradoxes-a-narrative-review-towards-a-personalized-patient-centered-approach
#16
REVIEW
Giorgina Barbara Piccoli, Maria Rita Moio, Antioco Fois, Andreea Sofronie, Lurlinys Gendrot, Gianfranca Cabiddu, Claudia D'Alessandro, Adamasco Cupisti
The history of dialysis and diet can be viewed as a series of battles waged against potential threats to patients' lives. In the early years of dialysis, potassium was identified as "the killer", and the lists patients were given of forbidden foods included most plant-derived nourishment. As soon as dialysis became more efficient and survival increased, hyperphosphatemia, was identified as the enemy, generating an even longer list of banned aliments. Conversely, the "third era" finds us combating protein-energy wasting...
April 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28394143/she-bought-the-unicorn-from-the-pet-store-six-to-seven-year-olds-are-strongly-inclined-to-generate-natural-explanations
#17
Shaylene E Nancekivell, Ori Friedman
In two experiments (N = 64), we told 6- to 7-year-olds about improbable or impossible outcomes (Experiment 1) and about impossible outcomes concerning ordinary or magical agents (Experiment 2). In both experiments, children claimed that the outcomes were impossible and could not happen, but nonetheless generated realistic and natural explanations for the outcomes. These findings show that 6- to 7-year-olds are strongly inclined to provide natural explanations. The findings are also informative about children's judgments about whether outcomes are possible, and further suggest that asymmetries between children's predictions and explanations may stem from differences in how these 2 forms of reasoning are constrained by possibility...
April 10, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28393694/peptide-drug-conjugate-a-novel-drug-design-approach
#18
Liang Ma, Chao Wang, Zihao He, Biao Cheng, Ling Zheng, Kun Huang
More than 100 years ago, German physician Paul Ehrlich first proposed the concept of selectively delivering "magic bullets" to tumors through targeting agents. The targeting therapy with antibody-drug conjugates (ADCs) and peptide-drug conjugate (PDCs), which are usually composed of monoclonal antibodies or peptides, toxic payloads and cleavage/noncleavage linkers, has been extensively studied for decades. The conjugates enable selective delivery of cytotoxic payloads to target cells, which result in improved efficacy, reduced systemic toxicity and improved pharmacokinetics (PK)/pharmacodynamics (PD) compared with traditional chemotherapy...
April 4, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28393279/non-equilibrium-hydrogen-exchange-for-determination-of-h-bond-strength-and-water-accessibility-in-solid-proteins
#19
Kristof Grohe, Kumar Tekwani Movellan, Suresh Kumar Vasa, Karin Giller, Stefan Becker, Rasmus Linser
We demonstrate measurement of non-equilibrium backbone amide hydrogen-deuterium exchange rates (HDX) for solid proteins. The target of this study are the slowly exchanging residues in solid samples, which are associated with stable secondary-structural elements of proteins. These hydrogen exchange processes escape methods measuring equilibrium exchange rates of faster processes. The method was applied to a micro-crystalline preparation of the SH3 domain of chicken α-spectrin. Therefore, from a 100% back-exchanged micro-crystalline protein preparation, the supernatant buffer was exchanged by a partially deuterated buffer to reach a final protonation level of approximately 20% before packing the sample in a 1...
April 9, 2017: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/28392024/proton-detection-of-mas-solid-state-nmr-spectra-of-half-integer-quadrupolar-nuclei
#20
Amrit Venkatesh, Michael P Hanrahan, Aaron J Rossini
Fast magic angle spinning (MAS) and proton detection has found widespread application to enhance the sensitivity of solid-state NMR experiments with spin-1/2 nuclei such as (13)C, (15)N and (29)Si, however, this approach is not yet routinely applied to half-integer quadrupolar nuclei. Here we have investigated the feasibility of using fast MAS and proton detection to enhance the sensitivity of solid-state NMR experiments with half-integer quadrupolar nuclei. The previously described dipolar hetero-nuclear multiple quantum correlation (D-HMQC) and dipolar refocused insensitive nuclei enhanced by polarization transfer (D-RINEPT) pulse sequences were used for proton detection of half-integer quadrupolar nuclei...
March 30, 2017: Solid State Nuclear Magnetic Resonance
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