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Eurycoma

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https://www.readbyqxmd.com/read/27818256/eurycoma-longifolia-as-a-potential-alternative-to-testosterone-for-the-treatment-of-osteoporosis-exploring-time-mannered-proliferative-differentiative-and-morphogenic-modulation-in-osteoblasts
#1
Hnin Ei Thu, Isa Naina Mohamed, Zahid Hussain, Ahmad Nazrun Shuid
ETHNOPHARMACOLOGICAL RELEVANCE: Eurycoma longifolia (EL) has been well-studied traditionally as a chief ingredient of many polyherbal formulations for the management of male osteoporosis. It has also been well-recognised to protect against bone calcium loss in orchidectomised rats. AIM OF THE STUDY: To evaluate the effects of EL on the time-mannered sequential proliferative, differentiative, and morphogenic modulation in osteoblasts compared with testosterone. MATERIALS AND METHODS: Cell proliferation was analysed using MTS assay and phase contrast microscopy...
November 3, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27800486/first-report-of-eurycoma-longifolia-jack-root-extract-causing-relaxation-of-aortic-rings-in-rats
#2
Bae Huey Tee, See Ziau Hoe, Swee Hung Cheah, Sau Kuen Lam
Although Eurycoma longifolia has been studied for erectile function, the blood pressure- (BP-) lowering effect has yet to be verified. Hence, this study aims at investigating the BP-lowering properties of the plant with a view to develop an antihypertensive agent that could also preserve erectile function. Ethanolic root extract was partitioned by hexane, dichloromethane (DCM), ethyl acetate, butanol, and water. The DCM fraction, found to be potent in relaxing phenylephrine- (PE-) precontracted rat aortic rings, was further purified by column chromatography...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27695271/inhibition-of-human-cytochrome-p450-2c8-catalyzed-amodiaquine-n-desethylation-effect-of-five-traditionally-and-commonly-used-herbs
#3
Yasotha Devi Muthiah, Chin Eng Ong, Siti Amrah Sulaiman, Rusli Ismail
BACKGROUND: In Southeast Asia and many parts of the world, herbal products are increasingly used in parallel with modern medicine. OBJECTIVE: This study aimed to investigate the effects of herbs commonly used in Southeast Asia on activity of cytochrome P450 2C8 (CYP2C8), an important human hepatic enzyme in drug metabolism. MATERIALS AND METHODS: The selected herbs, such as Eurycoma longifolia Jack (ELJ), Labisia pumila (LP), Echinacea purpurea (EP), Andrographis paniculata (AP), and Ginkgo biloba (GB), were subjected to inhibition studies using an in vitro CYP2C8 activity marker, amodiaquine N-desethylase assay...
October 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27399233/1hnmr-based-discriminatory-analysis-of-eurycoma-longifolia-from-different-locations-and-establishing-a-profile-for-primary-metabolites-identification-and-quassinoids-quantification
#4
Forough Ebrahimi, Baharudin Ibrahim, Chin Hoe Teh, Vikneswaran Murugaiyah, Chan Kit Lam
Quassinoids, the major secondary metabolites of Eurycoma longifolia roots, improve male fertility. Hence, it is crucial to investigate their quantitative level in E. longifolia extracts. A profile was established to identify the primary metabolites and major quassinoids, and quantify quassinoids using external calibration curves. Furthermore, the metabolic discrimination of E. longifolia roots from different regions was investigated. The (1)H-NMR spectra of the quassinoids, eurycomanone, eurycomanol, 13,21-dihydroeurycomanone, and eurycomanol-2-O-β-D-glycopyranoside were obtained...
July 11, 2016: Planta Medica
https://www.readbyqxmd.com/read/27144555/development-of-chromatographic-fingerprints-of-eurycoma-longifolia-tongkat-ali-roots-using-online-solid-phase-extraction-liquid-chromatography-spe-lc
#5
Nor Nasriah Zaini, Rozita Osman, Hafizan Juahir, Norashikin Saim
E. longifolia is attracting interest due to its pharmacological properties and pro-vitality effects. In this study, an online SPE-LC approach using polystyrene divinyl benzene (PSDVB) and C18 columns was developed in obtaining chromatographic fingerprints of E. longifolia. E. longifolia root samples were extracted using pressurized liquid extraction (PLE) technique prior to online SPE-LC. The effects of mobile phase compositions and column switching time on the chromatographic fingerprint were optimized. Validation of the developed method was studied based on eurycomanone...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/26978330/review-on-a-traditional-herbal-medicine-eurycoma-longifolia-jack-tongkat-ali-its-traditional-uses-chemistry-evidence-based-pharmacology-and-toxicology
#6
REVIEW
Shaheed Ur Rehman, Kevin Choe, Hye Hyun Yoo
Eurycoma longifolia Jack (known as tongkat ali), a popular traditional herbal medicine, is a flowering plant of the family Simaroubaceae, native to Indonesia, Malaysia, Vietnam and also Cambodia, Myanmar, Laos and Thailand. E. longifolia, is one of the well-known folk medicines for aphrodisiac effects as well as intermittent fever (malaria) in Asia. Decoctions of E. longifolia leaves are used for washing itches, while its fruits are used in curing dysentery. Its bark is mostly used as a vermifuge, while the taproots are used to treat high blood pressure, and the root bark is used for the treatment of diarrhea and fever...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/26899442/urinary-nmr-based-metabolomic-analysis-of-rats-possessing-variable-sperm-count-following-orally-administered-eurycoma-longifolia-extracts-of-different-quassinoid-levels
#7
Forough Ebrahimi, Baharudin Ibrahim, Chin-Hoe Teh, Vikneswaran Murugaiyah, Kit-Lam Chan
ETHNOPHARMACOLOGICAL RELEVANCE: Eurycoma longifolia (Tongkat Ali, TA) roots have been ethnically used as a remedy to boost male sexual desire, libido, energy and fertility. AIM OF THE STUDY: The study evaluated the effect of TA extracts with different quassinoid levels on rats sperm count and examined corresponding post-treatment urinary metabolic changes. MATERIALS AND METHODS: Twenty-four male Sprague-Dawley rats, categorized into 4 groups of 6 rats each, were orally administered for 48 days with water for the control (group 1), 125mg/kg of TA water extract (TAW, group 2), 125mg/kg of TA quassinoid-poor extract (TAQP, group 3) and 21mg/kg of TA quassinoid-rich extract (TAQR, group 4)...
April 22, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26832325/antiinflammatory-and-analgesic-effects-of-eurycoma-longifolia-extracts
#8
Young Min Han, Sang-Uk Woo, Min Sun Choi, Yu Na Park, Seung Hyun Kim, Hyungshin Yim, Hye Hyun Yoo
Eurycoma longifolia is one of the most popular herbal medicines in Southeast Asia. The purpose of this study is to evaluate the analgesic and anti-inflammatory effects of the methanolic extract of E. longifolia roots (TA) in vivo and to investigate the underlying mechanisms. TA was tested for analgesic activity by the hot plate test and acetic acid test in mice. The anti-inflammatory effect of TA was observed in carrageenan-induced paw edema in mice. The in vitro molecular study using macrophage cells was performed to elucidate the relevant mechanism...
March 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/26816234/immunomodulation-in-middle-aged-humans-via-the-ingestion-of-physta%C3%A2-standardized-root-water-extract-of-eurycoma-longifolia-jack-a-randomized-double-blind-placebo-controlled-parallel-study
#9
Annie George, Naoko Suzuki, Azreena Binti Abas, Kiminori Mohri, Masanori Utsuyama, Katsuiku Hirokawa, Tsuyoshi Takara
This study was aimed to investigate the capacity of a standardized root water extract of Eurycoma longifolia (Tongkat Ali, TA), Physta® to modulate human immunity in a middle-aged Japanese population. This randomized, double-blind, placebo-controlled, parallel study was conducted for 4 weeks. Eighty-four of 126 subjects had relatively lower scores according to Scoring of Immunological Vigor (SIV) screening. Subjects were instructed to ingest either 200 mg/day of TA or rice powder as a placebo for 4 weeks [TA and Placebo (P) groups] and to visit a clinic in Tokyo twice (weeks 0 and 4)...
April 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/26441666/decreased-expression-of-alpha-2-hs-glycoprotein-in-the-sera-of-rats-treated-with-eurycoma-longifolia-extract
#10
Yeng Chen, Wai-Mei Phang, Alan K-W Mu, Choon-Keat Chan, Bin-Seng Low, Sreenivasan Sasidharan, Kit-Lam Chan
Eurycoma longifolia is a Malaysian native herb that has been widely used as an aphrodisiac and a remedy for andropause. Although the physiological effects of the plant extract were predicted as a result of the alterations in protein expression, the key protein(s) involved in these alterations are still unclear. In the present study, we have investigated the effect of standardized E. longifolia extract on serum protein expression up to 28 days following oral administration in rats. Serum protein profiles were analyzed by 2-dimensional electrophoresis, and altered proteins were identified via mass spectrometry...
2015: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/26365449/efficacy-of-tongkat-ali-eurycoma-longifolia-on-erectile-function-improvement-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#11
REVIEW
Surachai Kotirum, Shaiful Bahari Ismail, Nathorn Chaiyakunapruk
OBJECTIVE: To determine the efficacy of Tongkat Ali (Eurycoma longifolia) herbal extract on erectile function improvement. METHODS: Comprehensive electronic databases were searched from inception through October 2014. Randomized controlled trials investigating Tongkat Ali compared to placebo were included. Outcome of interest was the improvement of erectile dysfunction. The difference of changes from baseline of the outcome between Tongkat Ali and placebo was pooled using weighted mean difference (WMD)...
October 2015: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/26291957/7-methoxy-9h-%C3%AE-carbolin-1-il-e-1-propenoic-acid-a-%C3%AE-carboline-alkaloid-from-eurycoma-longifolia-exhibits-anti-inflammatory-effects-by-activating-the-nrf2-heme-oxygenase-1-pathway
#12
Hai Dang Nguyen, Young-Yeon Choo, Tien Dat Nguyen, Hoai Nam Nguyen, Van Minh Chau, Jeong-Hyung Lee
Eurycoma longifolia is an herbal medicinal plant popularly used in Southeast Asian countries. In the present study, we show that 7-methoxy-(9H-β-carbolin-1-il)-(E)-1-propenoic acid (7-MCPA), a β-carboline alkaloid isolated from E. longifolia, exerted anti-inflammatory effects by activating the nuclear factor-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. 7-MCPA inhibited lipopolysaccharide (LPS)-induced production of nitric oxide (NO), prostaglandin E2 (PGE2 ), and interleukin-6 (IL-6) in RAW264...
March 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/26240600/in-vitro-evaluation-of-the-effects-of-eurycoma-longifolia-extract-on-cyp-mediated-drug-metabolism
#13
Young Min Han, In Sook Kim, Shaheed Ur Rehman, Kevin Choe, Hye Hyun Yoo
Eurycoma longifolia (Simaroubaceae) is a popular folk medicine that has traditionally been used in Southeast Asia as an antimalarial, aphrodisiac, antidiabetic, and antimicrobial and in antipyretic remedies. This study evaluates the effects of Eurycoma longifolia extract on cytochrome P450 (CYP) enzyme-mediated drug metabolism to predict the potential for herb-drug interactions. Methanolic extract of E. longifolia root was tested at concentrations of 1, 3, 10, 30, 100, 300, and 1000 µg/mL in human liver microsomes or individual recombinant CYP isozymes...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/26165243/a-new-anti-inflammatory-%C3%AE-carboline-alkaloid-from-the-hairy-root-cultures-of-eurycoma-longifolia
#14
Pham Bich Ngoc, Thanh Binh Pham, Hai Dang Nguyen, Thu Trang Tran, Hoang Ha Chu, Van Minh Chau, Jeong-Hyung Lee, Tien Dat Nguyen
One new β-carboline alkaloid 7-methoxy-(9H-β-carbolin-1-il)-(E)-1-propenoic acid (1) together with 9-methoxycanthin-6-one (2) and 9-hydroxycanthin-6-one (3) were isolated from the hairy-root cultures of Eurycoma longifolia. The effects of these compounds on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells were investigated. Compound 1 strongly inhibited the production of NO while 2 and 3 having weak or inactive effect. Consistently, compound 1 decreased the expression of cyclooxygenase-2 and inducible nitric oxide synthase...
June 2016: Natural Product Research
https://www.readbyqxmd.com/read/26082155/tongkat-ali-eurycoma-longifolia-a-possible-therapeutic-candidate-against-blastocystis-sp
#15
Sonal Girish, Suresh Kumar, Norhaniza Aminudin
BACKGROUND: In the local Malaysian context, herbal plants such as Eurycoma longifolia (Tongkat Ali), Orthosiphon stamineus (MisaiKucing), Ficus deltoidea (Mas Cotek), Zingiber officinale (Halia Bara) and Barringtonia racemosa (Putat) are known and widely used for its therapeutic properties. The first part of this study aims to screen for the anti-protozoal activity of these herbal plant extracts against Blastocystis sp. isolate subtype (ST) 3. Herbal extract with the highest efficacy was further fractionized into water and ethyl acetate fractions and tested against ST1, ST3 and ST5 Blastocystis sp...
2015: Parasites & Vectors
https://www.readbyqxmd.com/read/25914245/simultaneous-quantitation-of-six-major-quassinoids-in-tongkat-ali-dietary-supplements-by-liquid-chromatography-with-tandem-mass-spectrometry
#16
Young Min Han, Moonhee Jang, In Sook Kim, Seung Hyun Kim, Hye Hyun Yoo
Tongkat Ali (Eurycoma longifolia) is one of the most popular traditional herbs in Southeast Asia and generally consumed as forms of dietary supplements, tea, or drink additives for coffee or energy beverages. In this study, the liquid chromatography with tandem mass spectrometry method for the simultaneous quantitation of six major quassinoids of Tongkat Ali (eurycomanone, 13,21-dihydroeurycomanone, 13α(21)-epoxyeurycomanone, 14,15β-dihydroxyklaineanone, eurycomalactone, and longilactone) was developed and validated...
July 2015: Journal of Separation Science
https://www.readbyqxmd.com/read/25905468/9-hydroxycanthin-6-one-a-%C3%AE-carboline-alkaloid-from-eurycoma-longifolia-is-the-first-wnt-signal-inhibitor-through-activation-of-glycogen-synthase-kinase-3%C3%AE-without-depending-on-casein-kinase-1%C3%AE
#17
Kensuke Ohishi, Kazufumi Toume, Midori A Arai, Takashi Koyano, Thaworn Kowithayakorn, Takamasa Mizoguchi, Motoyuki Itoh, Masami Ishibashi
Wnt signaling regulates various processes such as cell proliferation, differentiation, and embryo development. However, numerous diseases have been attributed to the aberrant transduction of Wnt signaling. We screened a plant extract library targeting TCF/β-catenin transcriptional modulating activity with a cell-based luciferase assay. Activity-guided fractionation of the MeOH extract of the E. longifolia root led to the isolation of 9-hydroxycanthin-6-one (1). Compound 1 exhibited TCF/β-catenin inhibitory activity...
May 22, 2015: Journal of Natural Products
https://www.readbyqxmd.com/read/25862960/uncovering-potential-of-indonesian-medicinal-plants-on-glucose-uptake-enhancement-and-lipid-suppression-in-3t3-l1-adipocytes
#18
Lucy Lahrita, Eisuke Kato, Jun Kawabata
ETHNOPHARMACOLOGICAL RELEVANCE: As obesity is a key factor in the development of type 2 diabetes, lowering lipid accumulation in adipose tissues is as important as increasing insulin sensitivity in diabetic patients. The selected plant extracts used in this screen have been traditionally used in Indonesian medicine for the treatment of diabetes and its complications. AIM OF THE STUDY: To investigate the ability of the selected plants to both increase insulin sensitivity through the enhancement of glucose uptake after insulin induction in adipocytes and suppress lipid production in the same target cells...
June 20, 2015: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/25826409/the-in-vitro-and-in-vivo-anti-cancer-activities-of-a-standardized-quassinoids-composition-from-eurycoma-longifolia-on-lncap-human-prostate-cancer-cells
#19
Kind Leng Tong, Kit Lam Chan, Sazaly AbuBakar, Bin Seng Low, Hai Qiu Ma, Pooi Fong Wong
Quassinoids are a group of diterpenoids found in plants from the Simaroubaceae family. They are also the major bioactive compounds found in Eurycoma longifolia which is commonly used as traditional medicine in South East Asia to treat various ailments including sexual dysfunction and infertility. These uses are attributed to its ability to improve testosterone level in men. Chronic consumption of E. longifolia extracts has been reported to increase testosterone level in men and animal model but its effect on prostate growth remains unknown...
2015: PloS One
https://www.readbyqxmd.com/read/25511788/production-of-biomass-and-bioactive-compounds-from-adventitious-roots-by-optimization-of-culturing-conditions-of-eurycoma-longifolia-in-balloon-type-bubble-bioreactor-system
#20
Tao Lulu, So-Young Park, Rusli Ibrahim, Kee-Yoeup Paek
The present study aimed to optimize the conditions for the production of adventitious roots from Eurycoma longifolia Jack, an important medicinal woody plant, in bioreactor culture. The effects of the type and concentration of auxin on root growth were studied, as well as the effects of the NH4(+):NO3(-) ratio on adventitious root growth and the production of phenolics and flavonoids. Approximately 5 g L(-1) fresh weight of adventitious roots was inoculated into a 3 L balloon-type bubble bioreactor, which contained 2 L 3/4 MS medium supplemented with 30 g L(-1) sucrose and cultures were maintained in the dark for 7 weeks at 24 ± 1°C...
June 2015: Journal of Bioscience and Bioengineering
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