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Contrast nephropathy

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https://www.readbyqxmd.com/read/29776437/coenzyme-q10-combined-with-trimetazidine-in-the-prevention-of-contrast-induced-nephropathy-in-patients-with-coronary-heart-disease-complicated-with-renal-dysfunction-undergoing-elective-cardiac-catheterization-a-randomized-control-study-and-in-vivo-study
#1
Fei Chen, Fan Liu, Jingchao Lu, Xiuchun Yang, Bing Xiao, Yaqiong Jin, Jie Zhang
BACKGROUND: Contrast-induced nephropathy (CIN) is one of the common hospital-acquired acute renal failures. The purpose of this study was to investigate whether Coenzyme Q10 (CoQ10) and trimetazidine (TMZ) can prevent the occurrence of CIN after elective cardiac catheterization in patients with coronary artery disease complicated with renal dysfunction. METHODS: Consecutive coronary artery disease patients with renal insufficiency scheduled for coronary angiography were enrolled in randomized, paralleled, double-blind, controlled trial...
May 18, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29763899/tanshinone-iia-attenuates-contrast-induced-nephropathy-via-nrf2-activation-in-rats
#2
Rulian Liang, Qing Zhao, Guihua Jian, Dongsheng Cheng, Niansong Wang, Guangyuan Zhang, Feng Wang
BACKGROUND/AIMS: Tanshinone IIA is a chemical compound extracted from Salvia miltiorrhiza Bunge, a perennial plant also known as red sage used in traditional Chinese medicine. Tanshinone IIA has been shown to protect against various organ injuries. In this study, we hypothesized that Tanshinone IIA could play an anti-oxidative role in contrast-induced nephropathy (CIN) through enhancing Nrf2/ARE activation. METHODS: To test whether Tanshinone IIA can attenuate CIN, oxidative stress, and apoptosis, we utilized two models: an in vivo Sprague-Dawley rat model of ioversol-induced CIN and an in vitro cell model of oxidative stress in which HK2 cells, a human renal tubular cell line, are treated with hydrogen peroxide (H2O2)...
May 7, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29762257/evaluation-of-safety-guidelines-on-the-use-of-iodinated-contrast-material-conundrum-continued
#3
Estelle C Nijssen, Patty J Nelemans, Roger J Rennenberg, Vincent van Ommen, Joachim E Wildberger
OBJECTIVES: Recently, safety guidelines for the use of intravascular iodinated contrast material have been updated, and the recommended threshold for giving prophylaxis to prevent contrast-induced nephropathy (CIN) has been reduced to estimated glomerular filtration rate (eGFR) less than 30 mL/min/1.73 m. Data on this population in the context of CIN, especially evidence for efficacy of the recommendation of prophylactic intravenous hydration, are lacking. The aim of the current study was to test implicit assumptions underlying the guideline update: (1) patients with eGFR <30 mL/min/1...
May 14, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29743906/glomerular-filtration-decrease-after-diagnostic-cardiac-catheterisation-in-children-with-congenital-cardiac-malformation-the-role-of-serum-creatinine-cystatin-c-neutrophil-gelatinase-and-urine-output-monitoring
#4
Marcin Tkaczyk, Daria Tomczyk, Anna Jander, Sebastian Góreczny, Tomasz Moszura, Paweł Dryżek, Wojciech Krajewski, Ewa Głowacka, Agnieszka Wosiak
Introduction: Diagnosis of contrast induced-nephropathy (CIN) by a classic renal biomarker such as creatinine concentration can be delayed because of various factors that can influence this marker. Changes in new biomarkers such as neutrophil-gelatinase associated lipocalin (NGAL) and cystatin C are postulated to be more sensitive for recognizing patients prone to CIN-acute kidney injury (AKI). Aim: To investigate the role of NGAL and cystatin C as early biomarkers in the diagnosis of kidney injury after cardiac catheterisation...
2018: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/29743905/intravenous-n-acetylcysteine-for-the-prevention-of-contrast-induced-nephropathy-a-prospective-single-center-randomized-placebo-controlled-trial-the-inproc-trial
#5
Barbara Biernacka-Fiałkowska, Marta Szuksztul, Wojciech Suślik, Karolina Dzierwa, Łukasz Tekieli, Magdalena Kostkiewicz, Piotr Podolec, Piotr Pieniążek
Introduction: Contrast-induced nephropathy (CIN) is a common clinical problem that is growing in importance as an increasing number of tests and procedures which utilize contrast media (CM) are performed. Aim: To evaluate the efficacy of intravenous N-acetylcysteine (NAC) for prevention of CIN after diagnostic and/or interventional procedures requiring CM administration. Material and methods: In a prospective, single-center, randomized, placebo-controlled trial the preventive effects of N-acetylcysteine were evaluated in 222 patients undergoing elective angiography and/or angioplasty...
2018: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/29740934/preventive-effect-of-nicorandil-on-contrast-induced-nephropathy-a-meta-analysis-of-randomized-controlled-trials
#6
Shuang Li, Lin Wang, Yucai Liu, Qiang Hu
BACKGROUNDS: Contrast-induced nephropathy (CIN) is a common and serious side effect in patients undergoing angiocardiography or radiological procedures. We aimed to comprehensively assess the impact of nicorandil on CIN, by gathering currently available data. METHODS AND RESULTS: We searched three main electric databases (Medline/PubMed, EMBASE and Cochrane Central Register of Controlled Trials) from inception through April, 2017. Four randomized controlled trials involving 730 participants were included...
May 9, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29732146/oxidative-stress-and-kidney-injury-in-trans-radial-catheterization
#7
Konstantinos Tsarouhas, Christina Tsitsimpikou, Xrisoula Papantoni, Dimitra Lazaridou, Michael Koutouzis, Savvas Mazzaris, Ramin Rezaee, Charalambos Mamoulakis, Panagiotis Georgoulias, Charitini Nepka, Elias Rentoukas, Zenon Kyriakides, Aristidis Tsatsakis, Demetrios A Spandidos, Demetrios Kouretas
Oxidative stress is linked to coronary artery disease and is a major mechanism in contrast-induced nephropathy. Trans-radial approach in coronary angiography (CA) with minimized peri-procedural bleeding is expected to reduce acute kidney injury incidence. In the present study, oxidative stress patterns observed in radial CA and their associations with early manifestations of kidney injury are described. A total of 20 stable coronary disease patients submitted to CA and 17 sex-matched patients undergoing computed tomography for myoskeletal reasons were enrolled...
May 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29731093/graft-contrast-induced-nephropathy-caused-by-prerenal-transplant-computed-tomography-a-case-report
#8
S D Hwang, K-M Park, S W Lee, J-Y Han, M-J Kim, J H Song
BACKGROUND: We report a case of posttransplant contrast-induced nephropathy (CIN) that occurred after performing computed tomography (CT) scanning for pretransplant cardiac and vascular evaluation. CASE PRESENTATION: The patient had an 8-year history of hemodialysis and was admitted to the hospital for a kidney transplant from a deceased donor. Cardiac CT imaging and 3-dimensional low-extremity CT angiography were performed to confirm the patient's cardiac and iliac artery function...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29730853/renalguard-system-to-prevent-contrast-induced-acute-kidney-injury-in-japanese-patients-with-renal-dysfunction-respect-kidney-study
#9
Hiromasa Katoh, Tsuyoshi Nozue, Kazuki Horie, Takashi Sozu, Naoto Inoue, Ichiro Michishita
Increasing the urine flow rate (UFR) reduces the toxic effect of contrast media. Use of the RenalGuard system enables the achievement of a high UFR by maintaining intravascular volume and prevents the development of contrast-induced acute kidney injury (CI-AKI). However, the efficacy and safety of RenalGuard system have not yet been evaluated in Japan. This multicenter prospective study evaluated the efficacy and safety of the RenalGuard therapy in preventing CI-AKI development in 60 Japanese patients with renal dysfunction [estimated glomerular filtration rate (eGFR) < 45 mL/min/1...
May 5, 2018: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/29728370/serum-corin-level-is-associated-with-subsequent-decline-in-renal-function-in-patients-with-suspected-coronary-artery-disease
#10
Shang-Feng Yang, Ruey-Hsing Chou, Szu-Yuan Li, Shao-Sung Huang, Po-Hsun Huang
BACKGROUND: Higher circulatory corin in patients with cardiac diseases is associated with improved cardiovascular outcomes, and chronic cardiac dysfunction is a well-known cause of progressive renal dysfunction. This study aimed to determine the role of serum corin in predicting short-term and long-term renal outcomes after contrast exposure in patients with suspected coronary artery disease. METHODS AND RESULTS: Four hundred one patients who had received coronary angiography were enrolled...
May 4, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29726981/dickkopf-3-in-aberrant-endothelial-secretome-triggers-renal-fibroblast-activation-and-endothelial-mesenchymal-transition
#11
Mark Lipphardt, Hassan Dihazi, Noo Li Jeon, Sina Dadafarin, Brian B Ratliff, David W Rowe, Gerhard A Müller, Michael S Goligorsky
Background: Our laboratory has previously demonstrated that Sirt1endo-/- mice show endothelial dysfunction and exaggerated renal fibrosis, whereas mice with silenced endothelial transforming growth factor beta (TGF-β) signaling are resistant to fibrogenic signals. Considering the fact that the only difference between these mutant mice is confined to the vascular endothelium, this indicates that secreted substances contribute to these contrasting responses. Methods: We performed an unbiased proteomic analysis of the secretome of renal microvascular endothelial cells (RMVECs) isolated from these two mutants...
May 3, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29724974/comparison-of-the-transradial-and-transfemoral-approach-in-treatment-of-chronic-total-occlusions-with-similar-lesion-characteristics
#12
Mustafa Ahmet Huyut, Aylin Hatice Yamaç
OBJECTIVE: There is limited data on the efficacy and the safety of the transradial approach (TRA) for percutaneous coronary intervention (PCI) of chronic total occlusion (CTO), particularly in comparison with the transfemoral approach (TFA) in lesions with similar complexity. METHODS: We included 358 patients, who underwent elective CTO PCI between January 2012 and August 2017 and compared the radial (179 patients) and femoral (179 patients) approaches. The J-CTO score was similar in both groups (TRA, 2...
May 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29722117/upregulation-of-cd80-on-glomerular-podocytes-plays-an-important-role-in-development-of-proteinuria-following-pig-to-baboon-xeno-renal-transplantation-an-experimental-study
#13
Christopher J Rivard, Tatsu Tanabe, Miguel A Lanaspa, Hironosuke Watanabe, Shunichiro Nomura, Ana Andres-Hernando, Krystle Garth, Mitsuhiro Sekijima, Takuji Ishimoto, Yuichi Ariyoshi, Gabriela E Garcia, Jigesh Shah, Lennan Boyd, Masayuki Tasaki, Thomas Pomposelli, Akira Shimizu, David H Sachs, Richard J Johnson, Kazuhiko Yamada
We have previously reported that co-transplantation of the kidney with vascularized donor thymus from α-1, 3-galactosyl transferase gene knockout pigs, with an anti-CD154 with rituximab-based regimen led to improved xenograft survival in baboons with donor-specific unresponsiveness. However, nephrotic syndrome emerged as a complication in which the glomeruli showed mild mesangial expansion with similarities to minimal change disease (MCD) in humans. Since MCD is associated with CD80 expression in glomeruli and elevated urinary excretion, we evaluated a potential role for CD80 in xenograft nephropathy...
May 2, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29718868/iodixanol-versus-iopromide-in-patients-with-renal-insufficiency-undergoing-coronary-angiography-with-or-without-pci
#14
Junyi Zhang, Yufeng Jiang, Qing Rui, Min Chen, Nannan Zhang, Huajia Yang, Yafeng Zhou
BACKGROUND: The use of contrast agents during coronary angiography can result in contrast-induced nephropathy (CIN), particularly in patients with renal dysfunction. On the contrary, different contrast agents can induce different degree of changes in cardiac function. The objective of our meta-analysis was to compare the clinical safety of iso-osmolar contrast medium iodixanol to low-osmolar contrast medium iopromide in patients with renal insufficiency undergoing coronary angiography with or without percutaneous coronary intervention (PCI)...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29704102/diastolic-dysfunction-predicts-the-risk-of-contrast-induced-nephropathy-and-outcome-post-emergency-percutaneous-coronary-intervention-in-ami-patients-with-preserved-ejection-fraction
#15
Beibei Han, Yongguang Li, Zhifeng Dong, Qing Wan, Hong Shen, Jingbo Li, Meng Wei, Chengxing Shen
Patients with acute myocardial infarction (AMI) and reduced left ventricular ejection fraction (LVEF) are at high risk of contrast-induced nephropathy (CIN). However, the risk factors of CIN in AMI patients with preserved LVEF remain largely unknown now. The present study explored the relationship between LV diastolic function and CIN in this patient cohort. The present prospective cohort study enrolled 379 AMI patients with preserved LVEF (≥ 50%) who underwent emergency percutaneous coronary interventions (PCI)...
April 27, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29703048/tolvaptan-rescue-contrast-induced-acute-kidney-injury-a-case-report
#16
Wei-Chieh Lee, Hsiu-Yu Fang, Chih-Yuan Fang
RATIONALE: Contrast-induced acute kidney injury is one of the most serious adverse effects of contrast media and is related to three distinct but interacting mechanisms: medullary ischemia, formation of reactive oxygen species and direct tubular cell toxicity, especially in the patients with chronic kidney disease. The strategies of treatment, including stabilization of hemodynamic parameters and maintenance of normal fluid and electrolyte balance, were similar to the management of other types of acute kidney injury...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29698975/intrarenal-arterial-lesions-are-associated-with-higher-blood-pressure-reduced-renal-function-and-poorer-renal-outcomes-in-patients-with-iga-nephropathy
#17
Ying Zhang, Lili Sun, Suhan Zhou, Qihe Xu, Qiannan Xu, Dongyu Liu, Lu Liu, Ruimin Hu, Songxia Quan, Guolan Xing
BACKGROUND/AIMS: Arterial fibrotic intimal thickening and arteriolar hyaline are considered common pathological features in immunoglobulin A nephropathy (IgAN), whereas little is known about the acute pathological manifestations of endothelial cell injury. The aim of this study was to investigate characteristics of intrarenal arterial lesions and to estimate their prognostic values in patients with IgAN. The primary renal endpoint was a 50% reduction in estimated glomerular filtration rate (eGFR) or end-stage renal disease (ESRD)...
April 23, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29673704/synergistic-action-of-the-nephrotoxic-mycotoxins-ochratoxin-a-and-citrinin-at-nanomolar-concentrations-in-human-proximal-tubule-derived-cells
#18
Marie-Christin Schulz, Luise Schumann, Ulrike Rottkord, Hans-Ulrich Humpf, Michael Gekle, Gerald Schwerdt
Increased ochratoxin A (OTA) or citrinin (CIT) concentrations in food correlate with increased prevalence of tubule-interstitial nephropathy. We tested the hypothesis that co-exposure of human proximal tubule-derived epithelial cells (HK-2) to OTA and CIT promotes synergistic events indicative for inflammation, epithelial-to-mesenchymal-transition (EMT) or fibrosis. We measured markers of inflammation, EMT and fibrosis and investigated the role of MAP-kinases. Only concurrent but not individual exposure to OTA and CIT at nanomolar concentrations led to (i) an increase of TNF protein and mRNA, (ii) a decrease of COX-2 protein and mRNA, (iii) a decrease of E-cadherin protein and (iv) an increase of vimentin and α-SMA protein...
April 16, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29667231/feasibility-and-clinical-outcomes-of-rotational-atherectomy-for-heavily-calcified-side-branches-of-complex-coronary-bifurcation-lesions-in-the-real-world-practice-of-the-drug-eluting-stent-era
#19
Yu-Wei Chen, Chieh-Shou Su, Wei-Chun Chang, Tsun-Jui Liu, Kae-Woei Liang, Chih-Hung Lai, Hong-Xu Liu, Wen-Lieng Lee
OBJECTIVES: To evaluate the outcomes of rotational atherectomy for heavily-calcified side branches of coronary bifurcation lesions. BACKGROUND: Side-branch (SB) preservation is clinically important but technically challenging in heavily-calcified non-left main true bifurcation lesions. SB rotational atherectomy (SB RA) is sometimes mandatory but the clinical outcomes are not well studied. METHODS: We retrospectively studied the outcomes of patients who underwent RA at our institute for heavily calcified, balloon-uncrossable or-undilatable SB lesions over an approximately 5-year period (January 2011 to September 2016)...
April 17, 2018: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29649334/urinary-cgmp-predicts-major-adverse-renal-events-in-patients-with-mild-renal-impairment-and-or-diabetes-mellitus-before-exposure-to-contrast-medium
#20
Lyubov Chaykovska, Fabian Heunisch, Gina von Einem, Carl-Friedrich Hocher, Oleg Tsuprykov, Mira Pavkovic, Peter Sandner, Axel Kretschmer, Chang Chu, Saban Elitok, Johannes-Peter Stasch, Berthold Hocher
BACKGROUND: The use of iodine-based contrast agents entails the risk of contrast induced nephropathy (CIN). Radiocontrast agents elicit the third most common cause of nephropathy among hospitalized patients, accounting for 11-12% of cases. CIN is connected with clinically significant consequences, including increased morbidity, prolonged hospitalization, increased risk of complications, potential need for dialysis, and increased mortality rate. The number of in-hospital examinations using iodine-based contrast media has been significantly increasing over the last decade...
2018: PloS One
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