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Contrast nephropathy

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https://www.readbyqxmd.com/read/29156086/impact-of-low-level-bk-polyomavirus-viremia-on-intermediate-term-renal-allograft-function
#1
Johannes Korth, Marek Widera, Sebastian Dolff, Hana Guberina, Anja Bienholz, Alexandra Brinkhoff, Olympia Evdoxia Anastasiou, Andreas Kribben, Ulf Dittmer, Jens Verheyen, Benjamin Wilde, Oliver Witzke
BACKGROUND: BK polyomavirus (BKPyV)-associated nephropathy (PyVAN) is a significant cause of premature renal transplant failure. High-level BKPyV viremia is predictive for PyVAN, however, low-level BKPyV viremia does not necessarily exclude the presence of PyVAN. As data are limited whether or not low-level BKPyV viremia has an effect on intermediate-term graft outcome, this study analyzes the impact of low-level BKPyV viremia on intermediate-term graft function and outcome compared to high-level viremia and non-viremic patients...
November 20, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29152089/high-glucose-downregulates-myocardin-expression-in-rat-glomerular-mesangial-cells-via-the-erk-signaling-pathway
#2
Ming Li, Lijuan Xu, Guowei Feng, Yan Zhang, Xin Wang, Yuebing Wang
Mesangial cells (MCs), which are vascular smooth muscle-derived cells, occupy the central position in the glomerulus. Diabetic nephropathy (DN) is one of the most common diabetes complications and is likely attributed to the loss of MC contractility. Myocardin stimulates downstream vascular smooth muscle genes and regulates the contractility of vascular smooth muscle cells. Therefore, we hypothesized that myocardin is expressed in MCs and that high glucose is involved in the regulation of myocardin and downstream contractile genes in the context of DN...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29150416/-bicarbonate-from-physiology-to-treatment-for-all-clinicians
#3
Julie Beaume, Antoine Braconnier, Thibault Dolley-Hitze, Jean-Philippe Bertocchio
Acid-base regulation is essential to maintain homeostasis in humans. Carbonic acid/bicarbonate (H2CO3/HCO3(-)) couple is the most predominant extracellular buffer to keep plasma pH within a physiological range. The ability to (re)generate such a buffer is a key milestone that necessitates to understand a precise physiology of both renal tubule and digestive tract. Here, we first reviewed renal and digestive cycles of bicarbonate in physiology. We also reviewed pathological findings where acid-base disequilibrium is involved and nutritional and/or alkali therapy could be necessary...
November 14, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29148243/are-new-devices-required-to-reduce-contrast-load-in-the-cath-lab-or-is-behavioral-change-sufficient
#4
EDITORIAL
Toby Rogers, Lowell F Satler
A novel device that diverts a proportion of contrast injected by hand through the manifold can potentially reduce volume of contrast delivered to the patient by almost 50% to reduce risk of contrast-induced nephropathy. Another simple solution to reducing contrast volume is to limit the number of angiographic views and cine runs acquired. A conscious effort by the angiographer to limit the contrast volume to less than the eGFR should be considered.
November 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29142969/elucidation-of-renal-scars-in-children-with%C3%A2-vesicoureteral-reflux-using-contrast-enhanced-ultrasound-a-pilot%C3%A2-study
#5
David S Hains, Harris L Cohen, M Beth McCarville, Ellen E Ellison, Amy Huffman, Stacey Glass, Aslam H Qureshi, Keith R Pierce, Ashlyn L Cahill, Ashley Dixon, Noel Delos Santos
Introduction: Vesicoureteral reflux is a common disorder in children but can result in kidney scarring following acute pyelonephritis. The gold standard diagnostic to detect renal scars in children is (99m)Tc-dimercaptosuccinic acid (DMSA) scintigraphy. DMSA has a number of limitations including radiation exposure, need for sedation, and radiotracer supply shortages. Contrast-enhanced ultrasound (CEUS) is a technique whereby biocompatible microspheres of inert gas are administered i.v...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29141361/-effect-of-probucol-on-preventing-contrast-induced-nephropathy-in-patients-undergoing-percutaneous-coronary-intervention
#6
X Q Suo, S C Yang, Z H Ma, T T Sun, W Y Zhang, H L Cong, W H Lin, C Z Lu, F S Tian, N K Fu
Objective: To investigate the preventive effect, possible mechanism and safety of probucol on contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD). Methods: A total of 641 patients with coronary heart disease were consecutively enrolled from Department of Cardiology, in Tianjin Chest Hospital, Tianjin TEDA International Cardiovascular Hospital, Tianjin First Central Hospital, Tianjin Fourth Central Hospital. They were randomly divided into probucol group (n=321) and control group (n=320)...
November 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29123405/contrast-media-induced-nephropathy-how-has-italy-contributed-in-the-past-30-years-a-systematic-review
#7
REVIEW
Maurizio Sessa, Claudia Rossi, Annamaria Mascolo, Cristina Scavone, Gabriella di Mauro, Roberto Grassi, Liberata Sportiello, Salvatore Cappabianca, Concetta Rafaniello
Background and objective: The use of contrast media in Italy has exponentially increased in the past 3 decades. However, it is unknown whether there has been an increase in clinical research evaluating the risks associated with contrast media usage, especially regarding contrast-induced nephropathy. To fill this gap in knowledge, we performed a systematic review. Study eligibility criteria: Meta-analyses, observational studies, and clinical trials assessing contrast media-induced nephropathy as the safety outcome, in which at least one author was affiliated with an Italian university/health care structure, were eligble...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29120880/culprit-versus-multivessel-coronary-intervention-in-st-segment-elevation-myocardial-infarction-a-meta-analysis-of-randomized-trials
#8
Satyanarayana R Vaidya, Arman Qamar, Sameer Arora, Santhosh R Devarapally, Ashok Kondur, Prashant Kaul
BACKGROUND: The 2015 American College of Cardiology/American Heart Association update on primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) recommended PCI of the non-infarct-related artery at the time of primary PCI (class IIb recommendation). Despite evidence supporting complete revascularization in STEMI, its benefit on mortality rates is uncertain. METHODS: We searched all available databases for randomized controlled trials comparing complete multivessel percutaneous coronary intervention (CMV PCI) with infarct-artery-only revascularization in patients with STEMI...
November 8, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29118770/contrast-induced-nephropathy-is-less-common-in-patients-with-good-coronary-collateral-circulation
#9
Eyup Avci, Tarik Yildirim, Hasan Kadi
Background/Aims: Contrast-induced nephropathy (CIN) is a typically reversible type of acute renal failure that develops after exposure to contrast agents; underlying endothelial dysfunction is thought to be an important risk factor for CIN. Although the mechanism of coronary collateral circulation (CCC) is not fully understood, a pivotal role of the endothelium has been reported in many studies. The aim of this study was to investigate whether there is a relationship between CCC and CIN...
October 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29111980/impact-of-continuation-of-metformin-prior-to-elective-coronary-angiography-on-acute-contrast-nephropathy-in-patients-with-normal-or-mildly-impaired-renal-functions
#10
Veysel Oktay, İlknur Calpar Çıralı, Ümit Yaşar Sinan, Ahmet Yıldız, Murat Kazım Ersanlı
OBJECTIVE: Discontinuation of metformin treatment in patients scheduled for elective coronary angiography (CAG) is controversial because of post-procedural risks including acute contrast-induced nephropathy (CIN) and lactic acidosis (LA). This study aims to discuss the safety of continuing metformin treatment in patients undergoing elective CAG with normal or mildly impaired renal functions. METHODS: Our study was designed as a single-centered, randomized, and observational study including 268 patients undergoing elective CAG with an estimated glomerular filtration rate of >60 mL/min/1...
October 31, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29110052/contrast-enhanced-ultrasonography-for-assessment-of-tubular-atrophy-interstitial-fibrosis-in-immunoglobulin-a-nephropathy-a-preliminary-clinical-study
#11
Wenqi Yang, Shan Mou, Yao Xu, Jing Du, Li Xu, Fenghua Li, Hongli Li
PURPOSE: To investigate the potential of contrast-enhanced ultrasonography (CEUS) for evaluating the severity of tubular atrophy/interstitial fibrosis (TA/IF) in immunoglobulin A nephropathy (IgAN) patients. MATERIALS AND METHODS: A total of 80 patients with IgAN and 33 healthy adults were investigated. Patients were divided into three groups according to the TA/IF (T) grade of the Oxford classification: T0 (n = 28), T1 (n = 35), and T2 (n = 17). Patients and control subjects underwent conventional ultrasound (US) and CEUS...
November 6, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29106836/impact-of-transient-or-persistent-contrast-induced-nephropathy-on-long-term-mortality-after-elective-percutaneous-coronary-intervention
#12
Mitsuru Abe, Takeshi Morimoto, Yoshihisa Nakagawa, Yutaka Furukawa, Koh Ono, Takao Kato, Kazushige Kadota, Kenji Ando, Mitsuru Ishii, Nobutoyo Masunaga, Masaharu Akao, Takeshi Kimura
Contrast-induced nephropathy (CIN) is associated with increased long-term mortality. However, it is still controversial whether CIN is the cause of increased mortality or merely a marker of high-risk patients. The current study population included 5,516 patients who underwent their first elective percutaneous coronary intervention (PCI) in the Coronary REvascularization Demonstrating Outcome Study in Kyoto registry cohort-2. CIN was defined as an elevation in the peak serum creatinine (SCr) of ≥0.5 mg/dl from the baseline within 5 days after PCI...
September 19, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29104318/comparison-of-the-oxidation-of-carcinogenic-aristolochic-acid-i-and-ii-by-microsomal-cytochromes-p450-in-vitro-experimental-and-theoretical-approaches
#13
Václav Martínek, František Bárta, Petr Hodek, Eva Frei, Heinz H Schmeiser, Volker M Arlt, Marie Stiborová
Abstract: The herbal drug aristolochic acid, a natural mixture of 8-methoxy-6-nitrophenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid (AAI) and 6-nitrophenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid (AAII), is derived from Aristolochia species and is the cause of two nephropathies. Ingestion of aristolochic acid is associated with the development of urothelial tumors linked with aristolochic acid nephropathy and is implicated in the development of Balkan endemic nephropathy-associated urothelial tumors...
2017: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/29102563/tgf-%C3%AE-mediates-renal-fibrosis-via-the-smad3-erbb4-ir-long-noncoding-rna-axis
#14
Min Feng, Patrick Ming-Kuen Tang, Xiao-Ru Huang, Si-Fan Sun, Yong-Ke You, Jun Xiao, Lin-Li Lv, An-Ping Xu, Hui-Yao Lan
Transforming growth factor β (TGF-β)/Smad3 signaling plays a role in tissue fibrosis. We report here that Erbb4-IR is a novel long non-coding RNA (lncRNA) responsible for TGF-β/Smad3-mediated renal fibrosis and is a specific therapeutic target for chronic kidney disease. Erbb4-IR was induced by TGF-β1 via a Smad3-dependent mechanism and was highly upregulated in the fibrotic kidney of mouse unilateral ureteral obstructive nephropathy (UUO). Silencing Erbb4-IR blocked TGF-β1-induced collagen I and alpha-smooth muscle actin (α-SMA) expressions in vitro and effectively attenuated renal fibrosis in the UUO kidney by blocking TGF-β/Smad3 signaling...
October 5, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29097928/assessing-the-risk-of-contrast-induced-nephropathy-using-a-finger-stick-analysis-in-recalls-from-breast-screening-the-cinfibs-explorative-study
#15
I P L Houben, C J L Y van Berlo, O Bekers, E C Nijssen, M B I Lobbes, J E Wildberger
Purpose: To evaluate whether a handheld point-of-care (POC) device is able to predict and discriminate patients at potential risk of contrast-induced nephropathy (CIN) prior to iodine-based contrast media delivery. Methods and Materials: Between December 2014 and June 2016, women undergoing contrast-enhanced spectral mammography (CESM) with an iodine-based contrast agent were asked to have their risk of CIN assessed by a dedicated POC device (StatSensor CREAT) and a risk factor questionnaire based on national guidelines...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29095250/determination-of-the-optimal-target-level-of-proteinuria-in-the-management-of-patients-with-glomerular-diseases-by-using-different-definitions-of-proteinuria
#16
Youn Kyung Kee, Chan-Yun Yoon, Seung Jun Kim, Sung Jin Moon, Chan Ho Kim, Jung Tak Park, Beom Jin Lim, Tae Ik Chang, Ea Wha Kang, Jeong Hae Kie, Tae-Hyun Yoo, Hyun Joo Jeong, Shin-Wook Kang, Seung Hyeok Han
Proteinuria is a major determinant of adverse renal outcome, and its reduction slows renal progression in glomerular diseases. However, the optimal target of proteinuria in glomerular diseases is unclear, and discrepancies in the definition of proteinuria produce ambiguous findings. Here we investigated the optimal target of proteinuria by using different definitions of proteinuria. We analyzed 574 IgA nephropathy (IgAN), 175 membranous nephropathy (MGN), and 177 focal segmental glomerulosclerosis (FSGS) cases from 3 Korean kidney centers...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29089038/the-impact-of-n-acetylcysteine-and-ascorbic-acid-in-contrast-induced-nephropathy-in-critical-care-patients-an-open-label-randomized-controlled-study
#17
Eleni Palli, Demosthenes Makris, John Papanikolaou, Grigorios Garoufalis, Irini Tsilioni, Paris Zygoulis, Epaminondas Zakynthinos
BACKGROUND: The aim was to investigate whether the use of N-acetylcysteine and ascorbic acid reduce contrast-induced nephropathy incidence in critical care patients. METHODS: This was a one-center, two-arm, prospective, randomized, open-label, controlled trial in the Intensive Care Unit of the University Hospital of Larissa, Greece. Patients with stable renal function, who underwent non urgent contrast-enhanced computed tomography for diagnostic purposes, were included in the study...
October 31, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29073785/preventive-effects-of-alprostadil-against-contrast-induced-nephropathy-inpatients-with-renal-insufficiency-undergoing-percutaneous-coronary-intervention
#18
Shi-Cheng Yang, Nai-Kuan Fu, Jing Zhang, Min Liang, Hong-Liang Cong, Wen-Hua Lin, Feng-Shi Tian, Cheng-Zhi Lu, Ting-Ting Sun, Wen-Ya Zhang, Zhen-Hua Ma
We investigated the preventive effect of alprostadil on contrast-induced nephropathy (CIN) in patients with renal insufficiency undergoing percutaneous coronary intervention (PCI). A total of 300 patients with creatinine clearance (crCl) ≤60 mL/min undergoing PCI were randomly assigned to alprostadil or a control group. The primary end point was the incidence of CIN defined as an increase in serum creatinine (Scr) levels by ≥0.5 mg/dL or≥ 25% after administration of the contrast media within 72 hours...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/29071556/the-efficacy-of-probucol-combined-with-hydration-in-preventing-contrast-induced-nephropathy-in-patients-with-coronary-heart-disease-undergoing-percutaneous-coronary-intervention-a-multicenter-prospective-randomized-controlled-study
#19
Naikuan Fu, Shicheng Yang, Jing Zhang, Peng Zhang, Min Liang, Hongliang Cong, Wenhua Lin, Fengshi Tian, Chengzhi Lu
PURPOSE: To investigate the preventive effect of probucol combined with hydration on contrast-induced nephropathy (CIN) in patients with coronary heart disease undergoing percutaneous coronary intervention (PCI). METHODS: A total of 641 patients undergoing PCI were randomly assigned to either a probucol group (probucol 500 mg twice daily and hydration; n = 321) or a control group (hydration only; n = 320). The primary endpoint was the incidence of CIN, defined as an increase in serum creatinine (Scr) by ≥ 44...
October 25, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29064276/predictors-of-acute-kidney-injury-in-patients-admitted-with-st-elevation-myocardial-infarction-results-from-the-bremen-stemi-registry
#20
Johannes Schmucker, Andreas Fach, Matthias Becker, Susanne Seide, Stefanie Bünger, Robert Zabrocki, Eduard Fiehn, Bettina Würmann-Busch, Hermann Pohlabeln, Kathrin Günther, Wolfgang Ahrens, Rainer Hambrecht, Harm Wienbergen
BACKGROUND: Deterioration of renal function after exposition to contrast media is a common problem in patients with myocardial infarction undergoing percutaneous coronary interventions. The aim of the present study was to assess the incidence of acute kidney injury in patients admitted with ST-elevation-myocardial infarction (STEMI) and its association with infarction severity, comorbidities and treatment modalities, including amount of contrast media applied. METHODS: All patients with STEMI from the metropolitan area of Bremen, Germany are treated at the Bremen Heart Centre and since 2006 documented in the Bremen STEMI-Registry...
June 1, 2017: European Heart Journal. Acute Cardiovascular Care
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