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Contrast nephropathy

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https://www.readbyqxmd.com/read/28344312/a-case-of-anti-glomerular-basement-membrane-glomerulonephritis-complicated-by-type-1-diabetes-mellitus-mimicking-urinary-tract-infection
#1
Yoshihiro Aoki, Izumi Tanimoto, Yoshihiro Miyauchi, Yoshio Suzuki, Toshiaki Shiojiri
BACKGROUND Type 1 diabetes mellitus (DM) tends to complicate other autoimmune diseases. When considering renal dysfunction in patients with DM, diabetic nephropathy is a likely diagnosis. By contrast, anti-glomerular basement membrane (GBM) glomerulonephritis, an autoimmune disease, is one cause of rapidly progressive glomerulonephritis. CASE REPORT We report the case of a 44-year-old woman diagnosed with anti-glomerular basement membrane (GBM) glomerulonephritis. The diagnosis was made on the basis of serological test results and pathological findings of a renal biopsy...
March 27, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28341272/kidney-fibroblast-growth-factor-23-does-not-contribute-to-elevation-of-its-circulating-levels-in-uremia
#2
Maria L Mace, Eva Gravesen, Anders Nordholm, Jacob Hofman-Bang, Thomas Secher, Klaus Olgaard, Ewa Lewin
Fibroblast growth factor 23 (FGF23) secreted by osteocytes is a circulating factor essential for phosphate homeostasis. High plasma FGF23 levels are associated with cardiovascular complications and mortality. Increases of plasma FGF23 in uremia antedate high levels of phosphate, suggesting a disrupted feedback regulatory loop or an extra-skeletal source of this phosphatonin. Since induction of FGF23 expression in injured organs has been reported we decided to examine the regulation of FGF23 gene and protein expressions in the kidney and whether kidney-derived FGF23 contributes to the high plasma levels of FGF23 in uremia...
March 21, 2017: Kidney International
https://www.readbyqxmd.com/read/28340561/ascorbic-acid-ameliorates-renal-injury-in-a-murine-model-of-contrast-induced-nephropathy
#3
K Rollins, A Noorani, L Janeckova, T Jones, M Griffiths, M P Baker, J R Boyle
BACKGROUND: Contrast induced nephropathy (CIN) is the commonest cause of iatrogenic renal injury and its incidence has increased with the advent of complex endovascular procedures. Evidence suggests that ascorbic acid (AA) has a nephroprotective effect in percutaneous coronary interventions when contrast media are used. A variety of biomarkers (NGAL, NGAL:creatinine, mononuclear cell infiltration, apoptosis and RBP-4) in both the urine and kidney were assayed using a mouse model of CIN in order to determine whether AA can reduce the incidence and/or severity of renal injury...
March 24, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28337989/post-hoc-study-intravenous-hydration-treatment-in-chinese-patients-with-high-risk-of-contrast-induced-nephropathy-following-percutaneous-coronary-intervention
#4
Weijie Bei, Hualong Li, Kaiyang Lin, Kun Wang, Shiqun Chen, Xiaosheng Guo, Yong Liu, Ning Tan, Jiyan Chen
Contrast-induced nephropathy (CIN) develops after the injection of iodinated contrast media. This is a post hoc analysis of the data obtained from the TRUST study, which was a prospective, multicentre, observational study conducted to evaluate the safety and tolerability of the contrast medium iopromide in patients undergoing cardiac catheterization from August 2010 to September 2011 in China, conducted to explore the current status, trends and risk predictors of hydration treatment. The status of hydration to prevent CIN in each patient was recorded...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28320994/a-nomogram-to-predict-contrast-induced-nephropathy-in-patients-undergoing-percutaneous-coronary-intervention
#5
Xun Hu, Xiao-Dong Zhuang, Yi Li, Fei-Fei Li, Yue Guo, Zhi-Min Du, Xin-Xue Liao
Contrast-induced nephropathy (CIN) is the third leading cause of hospital-acquired acute kidney injury (AKI). Emerging evidence has revealed that soluble klotho (sklotho) could be a novel biomarker for early AKI diagnosis. The aims of this study were to assess the predictive role of sklotho for CIN and to develop a prediction nomogram in patients undergoing percutaneous coronary intervention (PCI). This study is registered on Clinicaltrials.gov (NCT 02650336).Patients aged 18 years or older undergoing planned PCI were prospectively recruited between May 2014 and July 2015...
March 21, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28320991/pre-procedural-risk-score-of-contrast-induced-nephropathy-in-elderly-patients-undergoing-elective-coronary-angiography
#6
Dan Lian, Yong Liu, Yuan-Hui Liu, Hua-Long Li, Chong-Yang Duan, Dan-Qing Yu
To establish a scoring model to predict the risk of contrast-induced nephropathy (CIN) in elderly patients undergoing elective coronary angiography (CAG).A total of 1286 patients aged > 65 years who had undergone elective CAG between August 2009 and February 2013 were enrolled in this study. They were randomly (3:2) assigned to a development (n = 756) or validation dataset (n = 530). Independent predictors of CIN were identified by using logistic regression and were assigned a weighted integer, which was used to establish a score model...
March 21, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28315934/gas1-expression-in-parietal-cells-of-bowman-s-capsule-in-experimental-diabetic-nephropathy
#7
Brenda I Luna-Antonio, Rafael Rodriguez-Muñoz, Carmen Namorado-Tonix, Paula Vergara, Jose Segovia, Jose L Reyes
Gas1 (Growth Arrest-Specific 1) is a pleiotropic protein with novel functions including anti-proliferative and proapoptotic activities. In the kidney, the expression of Gas1 has been described in mesangial cells. In this study, we described that renal parietal cells of Bowman's capsule (BC) and the distal nephron cells also express Gas1. The role of Gas1 in the kidney is not yet known. There is a subpopulation of progenitor cells in Bowman's capsule with self-renewal properties which can eventually differentiate into podocytes as a possible mechanism of regeneration in the early stages of diabetic nephropathy...
March 18, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28303661/immunological-and-physiological-observations-in-baboons-with-life-supporting-genetically-engineered-pig-kidney-grafts
#8
Hayato Iwase, Hidetaka Hara, Mohamed Ezzelarab, Tao Li, Zhongqiang Zhang, Bingsi Gao, Hong Liu, Cassandra Long, Yi Wang, Amy Cassano, Edwin Klein, Carol Phelps, David Ayares, Abhinav Humar, Martin Wijkstrom, David K C Cooper
BACKGROUND: Genetically engineered pigs could provide a source of kidneys for clinical transplantation. The two longest kidney graft survivals reported to date have been 136 and 310 days, but graft survival >30 days has been unusual until recently. METHODS: Donor pigs (n=4) were on an α1,3-galactosyltransferase gene-knockout (GTKO)/human complement regulatory protein (CD46) background (GTKO/CD46). In addition, the pigs were transgenic for at least one human coagulation regulatory protein...
March 17, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28303645/zero-contrast-percutaneous-coronary-intervention-on-calcified-lesions-facilitated-by-rotational-atherectomy
#9
Keyvan Karimi Galougahi, Gary S Mintz, Dimitri Karmpaliotis, Ziad A Ali
Percutaneous coronary intervention (PCI) in patients with advanced chronic kidney disease (CKD) is challenging due to frequent presence of complex calcified lesions and the very high risk of contrast-induced nephropathy (CIN). We report a strategy of "zero contrast" PCI, guided by intravascular imaging and physiology, performed in three patients with advanced CKD in whom severe calcification necessitated rotational atherectomy (RA) to facilitate and optimize PCI. This approach resulted in safe and successful PCI while preserving renal function...
March 17, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28302474/outcomes-of-endovascular-therapy-for-infrarenal-aortic-occlusion-of-tasc-ii-d-classification
#10
Koichi Morisaki, Terutoshi Yamaoka, Kazuomi Iwasa, Takahiro Ohmine
PURPOSE: This study aimed to investigate the treatment outcomes of endovascular therapy (EVT) in patients with infrarenal aortic occlusive disease. METHODS: Between January 2012 and December 2015, 11 patients with infrarenal aortic occlusion of Trans-Atlantic Inter-Society Consensus II D classification were treated. Procedural results, complications, and midterm results were analyzed retrospectively. RESULTS: The technical success was 81.8%...
March 13, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28302075/renal-effects-of-metallothionein-induction-by-zinc-in-vitro-and-in-vivo
#11
Moritz Schanz, Lea Schaaf, Juergen Dippon, Dagmar Biegger, Peter Fritz, Mark Dominik Alscher, Martin Kimmel
BACKGROUND: Metallothionein (MTT) is an endogenous antioxidant that can be induced by both zinc (Zn) and ischemia. In kidneys, increased MTT expression exerts a putative protective role in diabetes and hypoxia. Our goal was to further investigate the behavior of MTT under the influence of Zn and hypoxia in vitro and in vivo. METHODS: MTT expression was measured in vitro in cell cultures of proximal tubular cells (LCC-PK1) by immune-histochemistry and real-time PCR after incubation with increasing concentrations of Zn under hypoxic and non-hypoxic conditions...
March 16, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28292877/the-effects-of-dual-ppar%C3%AE-%C3%AE-agonism-compared-with-ace-inhibition-in-the-btbrob-ob-mouse-model-of-diabetes-and-diabetic-nephropathy
#12
Anette Ericsson, Pernilla Tonelius, Mark Lal, Alan Sabirsh, Gerhard Böttcher, Lena William-Olsson, Maria Strömstedt, Camilla Johansson, Gina Hyberg, Sofia Tapani, Ann-Cathrine Jönsson-Rylander, Robert Unwin
The leptin-deficient BTBRob/ob mouse develops progressive albuminuria and morphological lesions similar to human diabetic nephropathy (DN), although whether glomerular hyperfiltration, a recognized feature of early DN that may contribute to renal injury, also occurs in this model is not known. Leptin replacement has been shown to reverse the signs of renal injury in this model, but in contrast, the expected renoprotection by angiotensin-converting enzyme (ACE) inhibition in BTBRob/ob mice seems to be limited...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28285376/association-of-podocyte-autophagosome-numbers-with-idiopathic-membranous-nephropathy-and-secondary-membranous-nephropathy
#13
Juan Jin, Huifang Zhan, Bo Lin, Yiwen Li, Wei Zhang, Qiang He
PURPOSE: This study was to investigate the relation between the number of autophagosomes in podocytes and the syndromes of idiopathic membranous nephropathy (IMN) and secondary membranous nephropathy (sMN). METHODS: The pathological changes in the kidney tissues of patients were detected with the hematoxylin and eosin staining, the periodic acid-Schiff reagent treatment, the Masson's trichrome staining and the immunofluorescence detection (IF). Meanwhile, the autophagosomes in podocyte were analyzed by transmission electron microscopy and the IF assay pointing to LC3-II, an autophagic marker...
March 11, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28281738/efficacy-of-nicorandil-treatment-for-prevention-of-contrast-induced-nephropathy-in-high-risk-patients-undergoing-cardiac-catheterization-a-prospective-randomized-controlled-trial
#14
Leili Iranirad, Seyed Fakhreddin Hejazi, Mohammad Saleh Sadeghi, Shahram Arsang Jang
BACKGROUND: Contrast-induced nephropathy (CIN) remains to be a potentially serious complication of radiographic procedures and is the third leading cause of the acute kidney injury (AKI) among hospitalized patients. This clinical trial was performed to assess the preventive effect of oral nicorandil on CIN in high-risk patients undergoing cardiac catheterization. METHODS: In this prospective, randomized, controlled trial, 128 patients with at least two risk factors for CIN undergoing elective percutaneous coronary intervention (PCI) were randomly assigned to either the nicorandil group or the control group...
March 10, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28270639/new-insights-into-pathophysiology-diagnosis-and-treatment-of-renovascular-hypertension
#15
Fariba Samadian, Nooshin Dalili, Ali Jamalian
Renovascular disease includes renal artery stenosis, renovascular hypertension, and azotemic renovascular disease (ischemic nephropathy). Renovascular hypertension is defined as an elevated blood pressure caused by renal hypoperfusion, usually resulting from anatomic stenosis of the renal artery and activation of the renin-angiotensin system. It accounts for 1% to 2 % of all cases of hypertension in the general population and 5.8 % of secondary hypertension, but it plays a major role in treatable causes of hypertension in the young individuals...
March 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/28260077/atorvastatin-protects-against-contrast-induced-nephropathy-via-anti-apoptosis-by-the-upregulation-of-hsp27-in%C3%A2-vivo-and-in%C3%A2-vitro
#16
Xuyu He, Junqing Yang, Liwen Li, Hong Tan, Ying Wu, Peng Ran, Shuo Sun, Jiyan Chen, Yingling Zhou
Contrast-induced nephropathy (CIN) is an iatrogenic acute renal failure occurring following the intravascular injection of iodinated radiographic contrast medium. However, the regulatory mechanisms for CIN remain to be fully elucidated. The present study aimed to investigate whether atorvastatin protects against CIN via anti‑apoptotic effects by the upregulation of Hsp27 in vivo and in vitro. To determine whether atorvastatin attenuated CIN, the inflammatory response and apoptosis in vivo and in vitro, a rat model of iopamidol‑induced CIN was used, and human embryonic proximal tubule (HK2) cell damage was assessed...
April 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28256321/trimetazidine-in-conditions-other-than-coronary-disease-old-drug-new-tricks
#17
REVIEW
Hai Zou, Xing-Xing Zhu, Ya-Hui Ding, Qin-Yang Jin, Lin-Yan Qian, Dong-Sheng Huang, Xue-Jiang Cen
Trimetazidine (TMZ) has traditionally been used as an anti-ischemic drug for coronary artery disease by selectively inhibiting the mitochondrial long-chain 3-ketoacyl-CoA thiolase. Recently, new applications for this therapy have been investigated. This article reviews alternative uses for TMZ in non-coronary artery diseases, such as non-ischemic cardiomyopathy, sepsis, myocardial dysfunction induced by anti-cancer drugs, diabetic cardiomyopathy and contrast-induced nephropathy.
May 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28248861/clinical-effect-of-trimetazidine-on-prevention-of-contrast-induced-nephropathy-in-patients-with-renal-insufficiency-an-updated-systematic-review-and-meta-analysis
#18
REVIEW
Ziliang Ye, Haili Lu, Qiang Su, Wenqin Guo, Weiran Dai, Hongqing Li, Huafeng Yang, Lang Li
BACKGROUND: With the continuous development of cardiac interventional medicine, the incidence of contrast-induced nephropathy (CIN) is increasing every year, which is a serious threat to people's physical and mental health. Trimetazidine (TMZ) is a type of anti-ischemic drug developed in recent years, which can significantly reduce the incidence of CIN. At present, a systematic review and meta-analysis was conducted to evaluate the clinical effect of TMZ on prevention of CIN in patients with renal insufficiency...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28244599/fragmented-qrs-complex-predicts-contrast-induced-nephropathy-and-in-hospital-mortality-after-primary-percutaneous-coronary-intervention-in-patients-with-st-segment-elevation-myocardial-infarction
#19
Alparslan Kurtul, Mustafa Duran
BACKGROUND: Contrast-induced nephropathy (CIN) is associated with increased mortality after primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). Recently, fragmented QRS complex (fQRS) on 12-lead electrocardiography has been introduced as a marker of cardiovascular disease and is associated with increased morbidity and mortality. HYPOTHESIS: fQRS on ECG is associated with CIN and in-hospital mortality after primary PCI in patients with STEMI...
February 28, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28243014/contrast-induced-nephropathy-and-allergic-reaction-in-patients-who-were-given-intravenous-contrast-material-in-emergency-department
#20
İbrahim Caltekin, Pıxnar Yeşim Akyol, Fatih Esad Topal, Arif Karagöz, Erden Erol Ünlüer
No abstract text is available yet for this article.
January 2017: Journal of Emergencies, Trauma, and Shock
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