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Contrast nephropathy

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https://www.readbyqxmd.com/read/27907885/complete-revascularization-versus-culprit-only-revascularization-in-st-segment-elevation-myocardial-infarction-and-multivessel-disease-patients-undergoing-primary-percutaneous-coronary-intervention-a-meta-analysis-and-trial-sequential-analysis
#1
REVIEW
Chong-Hui Wang, Shu-Yang Zhang, Xiao-Feng Jin
The present study compared the outcomes of complete revascularization (CR) and culprit-only revascularization (COR) performed during primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease through a meta-analysis in order to determine which strategy is more appropriate. Published randomized controlled trials (RCTs) were retrieved from the PubMed, EMBASE, and CENTRAL databases. Eight RCTs with 2060 patients were selected (1080 patients underwent CR [immediate (ICR) or staged (SCR)] and 980 patients underwent COR)...
November 10, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27906613/urinary-excretion-of-uric-acid-allantoin-and-8-oh-deoxyguanosine-in-uricase-knockout-mice
#2
K Inazawa, S Yamaguchi, M Hosoyamada, T Fukuuchi, N H Tomioka, N Yamaoka, K Kaneko
Although uricase-knockout (Uox KO) mice are reported to develop uric acid (UA) nephropathy, those that mature without severe nephropathy could be useful for research into purine metabolism in humans. In this study, we measured the urinary excretion of creatinine, UA, allantoin, and 8-hydroxy-2'-deoxyguanosine (8-OHdG) collected from Uox KO mice housed in metabolic cages. UA and allantoin were determined using liquid chromatography-mass spectrometry and creatinine and 8-OHdG were measured with a commercial kit...
December 2016: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/27898408/sulodexide-protects-contrast-induced-nephropathy-in-sprague-dawley-rats
#3
Qing Zhao, Jianyong Yin, Zeyuan Lu, Yiwei Kong, Guangyuan Zhang, Binghui Zhao, Feng Wang
BACKGROUND: Sulodexide is a powerful antithrombin agent with reno-protective property. However, whether it has beneficial effects on Contrast-Induced Nephropathy (CIN) remained elusive. In the current study, we evaluated the therapeutic effects of Sulodexide on CIN and investigated the potential mechanisms. METHODS: CIN model was induced by intravenous injection of indomethacin, followed by Ioversol and L-NAME. Sprague-Dawley rats were divided into 4 groups: control group, CIN group, CIN+vehicle group (CIN rats pretreated with vehicle) and CIN+ Sulodexide (CIN rats pretreated with Sulodexide)...
November 30, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27897324/serum-cystatin-c-is-not-superior-to-serum-creatinine-for-early-diagnosis-of-contrast-induced-nephropathy-in-patients-who-underwent-angiography
#4
Qian Xu, Na-Na Wang, Shao-Bin Duan, Na Liu, Rong Lei, Wei Cheng, Shun-Ke Zhou
BACKGROUND: Iodiated contrast-induced nephropathy (CIN) is a serious complication of contrast-enhanced imaging. The aim of this study was to evaluate the diagnostic sensitivities and specificities of serum cystatin C (sCys C) and serum creatinine (sCr) for CIN and to further investigate difference of the incidence, risk factors, and in-hospital and 3-month prognosis of CIN according to sCys C criteria and sCr criteria. METHODS: We prospectively evaluated 213 patients who underwent angiography...
November 29, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27882134/expression-of-neutrophil-gelatinase-associated-lipocalin-in-low-osmolar-contrast-induced-nephropathy-in-rats-and-the-effect-of-n-acetylcysteine
#5
Wen-Hua Li, Lin Wang, Hai-Yan He, Jing Chen, Ya-Ren Yu
Serum creatinine (Scr), which is a conventional indicator of contrast-induced nephropathy (CIN), is unable to reflect the damage of kidney promptly. The present study aimed to investigate the value of neutrophil gelatinase-associated lipocalin (NGAL) in kidney and serum of CIN rats to observe whether NGAL can be used as a superior indicator of CIN. Furthermore, N-acetylcysteine (NAC) was used to assess its effect on CIN. A total of 120 adult male Sprague Dawley rats were randomly divided into four groups (n=30/group): CIN rats (CIN), normal rats treated with NAC (NAC), CIN rats treated with NAC (NAC+CIN) and the control group (CON)...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27876003/pla2r-antibodies-and-pla2r-glomerular-deposits-in-psoriasis-patients-with-membranous-nephropathy
#6
Yong-Chun Ge, Bo Jin, Cai-Hong Zeng, Ming-Chao Zhang, Da-Cheng Chen, Ru Yin, Wei-Bo Le
BACKGROUND: The association between psoriasis and membranous nephropathy (MN) remains largely unclear. We examined the prevalence of serum PLA2R antibody and characterized the expression of PLA2R and THSD7A in glomeruli in patients with MN and psoriasis. METHODS: A total of 24 patients with MN without evidence of a secondary cause except psoriasis were enrolled. The clinical and pathological features were retrospectively analyzed. Serum anti-PLA2R antibody was measured using IFA Mosaic...
November 22, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27863354/contrast-media-use-in-patients-with-chronic-kidney-disease-undergoing-coronary-angiography-a-systematic-review-and-meta-analysis-of-randomized-trials
#7
Bhavi Pandya, Jean Chaloub, Valay Parikh, Sainath Gaddam, Jonathan Spagnola, Suzanne El-Sayegh, Marc Bogin, Ruben Kandov, James Lafferty, Sripal Bangalore
BACKGROUND: Patients with chronic kidney disease (CKD) undergoing coronary angiography (CA), adequate hydration and minimizing volume of contrast media (CM) are class 1b recommendations for preventing contrast induced nephropathy (CIN). Current data are insufficient to justify specific recommendations about isoosmolar vs. low-osmolar contrast media by the ACCF/AHA/SCAI guidelines. METHODS: Randomized trials comparing IOCM to LOCM in CKD stage 3 and above patients undergoing CA, and reporting incidence of CIN (defined by a rise in creatinine of 25% from baseline) were included in the analysis...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27861357/the-effect-of-alprostadil-on-preventing-contrast-induced-nephropathy-for-percutaneous-coronary-intervention-in-diabetic-patients-a-systematic-review-and-meta-analysis
#8
Ziliang Ye, Haili Lu, Wenqin Guo, Weiran Dai, Hongqing Li, Huafeng Yang, Lang Li
BACKGROUND: At present, there are a lot of research about the effect of Alprostadil on preventing contrast-induced nephropathy for percutaneous coronary intervention (PCI) in diabetic patients, but the clinical efficacy is not consistent, so we conduct this study and therefore determine the dominant strategy for the treatment of PCI in diabetic patients based on the best evidence currently. METHODS: An electronic database search was conducted in MEDLINE, Embase, Cochrane library, CBM, CNKI, VIP, and WanFang to retrieve randomized controlled trial (RCT) comparing Alprostadil versus hydration on preventing CIN for PCI in diabetic patients...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27852844/bilirubin-levels-are-associated-with-contrast-induced-nephropathy-in-peripheral-artery-disease
#9
Ertan Vuruşkan, Erhan Saraçoğlu
The relationship between contrast-induced nephropathy (CIN) and oxidative mechanisms is well documented. Our aim was to demonstrate the possible relationship between CIN and serum bilirubin as an antioxidant molecule. This retrospective study included 359 patients with peripheral artery disease (PAD) who underwent peripheral diagnostic angiography; 179 developed CIN after the intervention and another 180 were the control group, matched for age, gender, and cardiovascular risk factors. Baseline, 48- to 72-hour, and 30-day laboratory values, major adverse cardiovascular events, and dialysis requirements were recorded...
November 15, 2016: Angiology
https://www.readbyqxmd.com/read/27850363/725-contrast-induced-nephropathy-in-stroke-patients-undergoing-ct-angiography-cinister-study
#10
Shaun Rowe, Brandon Hawkins, Leslie Hamilton, B Cole Seaton, Matthew Buzzeo, Jennifer Henry, Andrew Ferrell, Brian Wiseman
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27836988/sphingomyelinase-like-phosphodiesterase-3b-mediates-radiation-induced-damage-of-renal-podocytes
#11
Anis Ahmad, Alla Mitrofanova, Jacek Bielawski, Yidong Yang, Brian Marples, Alessia Fornoni, Youssef H Zeidan
The molecular mechanisms responsible for the development of proteinuria and glomerulosclerosis in radiation nephropathy remain largely unknown. Podocytes are increasingly recognized as key players in the pathogenesis of proteinuria in primary and secondary glomerular disorders. The lipid-modulating enzyme sphingomyelin phosphodiesterase acid-like 3B (SMPDL3b) is a key determinant of podocyte injury and a known off target of the anti-CD20 antibody rituximab (RTX). The current study investigates the role of sphingolipids in radiation-induced podocytopathy...
November 11, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27834856/stearoyl-coa-desaturase-1-protects-cells-against-lipotoxicity-mediated-apoptosis-in-proximal-tubular-cells
#12
Tamaki Iwai, Shinji Kume, Masami Chin-Kanasaki, Shogo Kuwagata, Hisazumi Araki, Naoko Takeda, Takeshi Sugaya, Takashi Uzu, Hiroshi Maegawa, Shin-Ichi Araki
Saturated fatty acid (SFA)-related lipotoxicity is a pathogenesis of diabetes-related renal proximal tubular epithelial cell (PTEC) damage, closely associated with a progressive decline in renal function. This study was designed to identify a free fatty acid (FFA) metabolism-related enzyme that can protect PTECs from SFA-related lipotoxicity. Among several enzymes involved in FFA metabolism, we identified stearoyl-CoA desaturase-1 (SCD1), whose expression level significantly decreased in the kidneys of high-fat diet (HFD)-induced diabetic mice, compared with non-diabetic mice...
November 9, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27832559/balancing-the-risks-and-benefits-of-using-emergency-diagnostic-radiocontrast-studies-to-diagnose-life-threatening-illness-in-critically-ill-patients-a-decision-analysis
#13
K M Ho
Diagnosis of many life-threatening illnesses, including acute pulmonary embolism, aortic dissection, and ischaemic bowel disease, requires confirmatory radiological imaging with radiocontrast. It is well established that radiocontrast can induce acute kidney injury, especially in patients with pre-existing renal impairment. The decision to proceed with a radiological study with radiocontrast to confirm or exclude a life-threatening, but potentially reversible, illness in patients with renal impairment is difficult...
November 2016: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/27831955/ce-preventing-contrast-induced-acute-kidney-injury
#14
Yvonne Gallegos, Asma Ali Taha, Dana N Rutledge
: Diagnostic radiographic imaging scans using intravascular iodinated contrast media can lead to various complications. The most salient of these is contrast-induced acute kidney injury (CI-AKI) or contrast-induced nephropathy, a potentially costly and serious patient safety concern. Prevention strategies are the cornerstone of evidence-based clinical management for patients receiving contrast agents. These include preprocedure screening, stratification of patients based on risk factors, and protective interventions, the most important of which is hydration both before and after the radiographic imaging scan...
December 2016: American Journal of Nursing
https://www.readbyqxmd.com/read/27828735/contrast-media-induced-renal-inflammation-is-mediated-through-hmgb1-and-its-receptors-in-human-tubular-cells
#15
Xiao-Feng Guan, Qing-Jie Chen, Xiao-Cong Zuo, Ren Guo, Xiang-Dong Peng, Jiang-Lin Wang, Wen-Jun Yin, Dai-Yang Li
With the rapid development of imaging diagnosis and interventional therapy, contrast media (CM) are widely used in clinics. However, contrast-induced nephropathy (CIN) is the third leading cause of hospital-acquired acute renal failure accounting for 10-12% of all causes of hospital-acquired renal failure. Recent study found that inflammation may participate in the pathogenesis of CIN, but the role of it remains unclear. HK-2 cells were treated with Iohexol, Urografin, and mannitol. Two types of CM increased the release of HMGB1 in cell supernatant accompanied by increased expression of TLR2 and CXCR4...
November 9, 2016: DNA and Cell Biology
https://www.readbyqxmd.com/read/27818460/different-expression-patterns-of-toll-like-receptor-mrnas-in-blood-mononuclear-cells-of-iga-nephropathy-and-iga-vasculitis-with-nephritis
#16
Ayano Saito, Atsushi Komatsuda, Hajime Kaga, Ryuta Sato, Masaru Togashi, Shin Okuyama, Hideki Wakui, Naoto Takahashi
Mucosal immunity may play a key role in IgA nephropathy (IgAN) and IgA vasculitis with nephritis (IgAVN). IgAVN is characterized by the presence of non-thrombocytopenic palpable purpura, associated with glomerulonephritis with IgA-dominant immune deposits. Recent studies have shown the up-regulation of Toll-like receptors (TLRs) in patients with IgAN or IgAVN. Among TLRs that mediate innate immune reactions, TLR2, TLR4, and TRL5 recognize bacterial components, while TLR3, TLR7, and TLR9 recognize viral components...
2016: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27814282/nephroprotective-effects-of-remote-ischemic-preconditioning-in-coronary-angiography
#17
Naufal Zagidullin, Alina Dunayeva, Alexander Gilmanov, Shamil Zagidullin, Valentin Pavlov
BACKGROUND: Contrast-induced nephropathy (CIN) is a formidable side effect of iodinated contrast medium use in subjects undergoing coronary angiogram (CAG). Remote ischemic preconditioning (RIPC) may reduce the risk of CIN. AIM: The aim of the study was to investigate the nephroprotective effects of RIPC in coronary heart disease (CHD) in patients, undergoing CAG, with mild to moderate lowered estimated glomerular filtration rate (eGFR). MATERIALS: In the randomized, blinded, sham RIPC (sRIPC) controlled study 51 patients with CHD and GFR less than 80 mL/min/m2, undergoing CAG, were investigated...
November 4, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27814269/preprocedural-high-sensitivity-c-reactive-protein-predicts-contrast-induced-nephropathy-and-long-term-outcome-after-coronary-angiography
#18
Xiao-Sheng Guo, Kai-Yang Lin, Hua-Long Li, Ji-Yan Chen, Ying-Ling Zhou, Yong Liu, Ning Tan, Emily R Atkins, Peng Ran, Jun-Qing Yang, Deng-Xuan Wu, Shi-Qun Chen, Chong-Yang Duan, Ping-Yan Chen
We investigated whether high-sensitivity C-reactive protein (hsCRP) levels were associated with contrast-induced nephropathy (CIN) and long-term mortality after coronary angiography (CAG). Patients (N = 2133) undergoing CAG with preprocedural hsCRP were consecutively enrolled. High-sensitivity C-reactive protein was measured before angiography. Median follow-up was 2.3 years. The overall incidence of CIN was 2.77% (59 of 2133). There was a positive trend of hsCRP quartiles (Q) with rates of CIN: 0.9% for Q1 (<1...
October 25, 2016: Angiology
https://www.readbyqxmd.com/read/27805502/cell-therapy-in-solid-organ-transplant
#19
Hassan Argani
In solid-organ transplant, cell therapy is used as an immunomodulation therapy or as a functioning graft (bioengineering medicine). Before such treatment can be more accepted among transplant societies, some uncertainties should be clarified. These include: why is such therapy mandatory? What are the indications for this therapy, and what are the mechanism(s) of actions? What types of cells are involved and what are their routes of actions? Finally, what is known about the safety? In general, the risks associated with intravenous administration of immunoregulatory cell products are similar to those encountered with conventional blood transfusions...
November 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27801538/added-value-of-multimodal-computed-tomography-imaging-analysis-of-1994-acute-ischaemic-strokes
#20
O Bill, M Faouzi, R Meuli, P Maeder, M Wintermark, P Michel
BACKGROUND AND PURPOSE: Multimodal computed tomography (CT) based imaging (MCTI) is widely used in acute ischaemic stroke. It was postulated that the use of MCTI is associated with improved patient outcome without causing harm. METHODS: All patients with an acute ischaemic stroke and CT-based imaging within 24 h from the ASTRAL (Acute Stroke Registry and Analysis of Lausanne) registry were included. Preceding demographic, clinical, biological, radiological and follow-up data were collected...
November 1, 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
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