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https://www.readbyqxmd.com/read/29138589/clinical-characteristics-and-outcome-of-toxicity-from-amanita-mushroom-poisoning
#1
Satariya Trakulsrichai, Charuwan Sriapha, Achara Tongpoo, Umaporn Udomsubpayakul, Sunun Wongvisavakorn, Sahaphume Srisuma, Winai Wananukul
Objective: To describe and analyze the clinical characteristics and outcome of amatoxin poisoning cases. Methods: We performed a retrospective cohort study of amatoxin poisoning cases from Ramathibodi Poison Center Toxic Exposure Surveillance System, from May 2013 to August 2015. Results: There were 30 consultations with a total of 55 poisoning cases. Most cases were male and from the north-east region. Hepatitis, acute kidney injury, jaundice, and coagulopathy accounted for 74%, 46...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/29081461/rapid-lc-ms-determination-of-acromelic-acids-a-and-b-toxic-constituents-of-the-mushroom-paralepistopsis-acromelalga
#2
Naoki Yoshioka, Hitoshi Ouchi, Toshiyuki Kan, Masashi Yoshida, Motoyuki Nomura
A rapid LC-MS method was developed for determination of acromelic acids A and B, which are toxic constituents of Paralepistopsis acromelalga (=Clitocybe acromelalga), in mushroom samples. Acromelic acids were extracted twice with 50% methanol and the extract was passed through a syringe filter, and then analyzed by LC-MS. The LC separation was performed on a multi-mode ODS column. The recoveries of acromelic acids A and B spiked into blank mushroom samples at 2.5 μg/g were 93 and 74%, respectively. This method was applied to the remaining mushroom sample from a food poisoning case...
2017: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/29078264/overview-of-ganoderma-sinense-polysaccharide-an-adjunctive-drug-used-during-concurrent-chemo-radiation-therapy-for-cancer-treatment-in-china
#3
REVIEW
Yifei Jiang, Yajing Chang, Yong Liu, Meng Zhang, Heng Luo, Cui Hao, Pengjiao Zeng, Yue Sun, Hua Wang, Lijuan Zhang
Ganoderma sinense or "Chinese Lingzhi" is a well-known medicinal fungus in China for more than 2000 years. Polysaccharide is the main immunomodulatory and antitumor component in G. sinense. In 2010, G. sinense polysaccharide (GSP) tablet is approved as an adjunctive therapeutic drug in China for treating leukopenia and hematopoietic injury caused by concurrent chemo/radiation therapy during cancer treatment by the State Food and Drug Administration (SFDA). β-glucan, an established immunostimulant, is one of the components in GSP...
October 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29059397/pro-high-dose-of-therapeutic-plasma-exchange-mind-the-gap
#4
Carsten Hafer, Jan T Kielstein
'Mind the gap' is a recorded warning phrase used in the London Tube since 1969. The following article is meant to be a warning of an increasing knowing-doing gap in routine practice of therapeutic plasma exchange (TPE), a treatment method that is used more and more throughout the world. The American Society of Apheresis recommendations, including the most recent ones from 2016, suggest using a TPE volume of 1.0-1.5 times the actual calculated plasma volume of the patient. There are only a few exceptions to that rule, such as the recommnded exchange volume in vasculitis or mushroom poisoning...
September 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29052443/investigation-and-analysis-of-galerina-sulciceps-poisoning-in-a-canteen
#5
Hong Xiang, Yajuan Zhou, Changlin Zhou, Shiguang Lei, Hong Yu, Yafang Wang, Shu Zhu
INTRODUCTION: Guizhou Province in China has an abundant resource of wild mushrooms, including numerous poisonous species which contain various toxins. The mortality rate from wild mushroom poisoning has been high in this area in recent years. Galerina sulciceps is a dangerously toxic mushroom which can be fatal if ingested. METHODS: we report on an epidemiological investigation of G. sulciceps poisoning which occurred in Duyun City of Guizhou Province. The characteristics of this species, its toxicity, observed clinical features, laboratory data, treatment modality, and prognosis were investigated in order to provide a reference point for the prevention and treatment of this kind of mushroom poisoning...
October 20, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28989155/-analysis-of-spatiotemporal-patterns-and-influential-factors-for-mushroom-poisoning-in-hunan-province-in-2015
#6
Wenpei Shi, Jinjun Liang, Tingting Wang, Yuan Liu, Lizhang Chen
To understand the spatial distribution of mushroom poisoning in Hunan Province and its influential factors, and to provide the evidence for control of the mushroom poisoning.
 Methods: The surveillance data for mushroom poisoning cases from 122 counties in Hunan Province in 2015 were collected. Based on geographical information system database, spatial autocorrelation analysis and spatial regression analysis (via OpenGeoDa) was conducted.
 Results: The incidence of mushroom poisoning in Hunan Province in 2015 was 2...
September 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28981366/cancer-related-to-herbs-and-dietary-supplements-online-table-of-case-reports-part-5-of-5
#7
Amy C Brown
A current listing of potentially life-threatening, cancer-related dietary supplements (DSs; includes herbs) based on PubMed case reports was summarized in online tables that can now be updated continually to forewarn United States consumers, clinicians, and DS companies. Documented PubMed case reports were used to create a "Toxic Table" related to cancer (1966 to April 2016, and cross-referencing). Keywords included "herb" or "dietary supplement" combined with "cancer" as well as the specific herb "name" combined with "cancer" and sometimes "toxicity...
October 5, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28981338/heart-toxicity-related-to-herbs-and-dietary-supplements-online-table-of-case-reports-part-4-of-5
#8
Amy C Brown
BACKGROUND: The purpose of this review was to create an online research summary table of heart toxicity case reports related to dietary supplements (DS; includes herbs). METHODS: Documented PubMed case reports of DS appearing to contribute to heart-related problems were used to create a "Toxic Table" that summarized the research (1966 to April, 2016, and cross-referencing). Keywords included "herb," "dietary supplement," and cardiac terms. Case reports were excluded if they were herb combinations (some exceptions), Chinese herb mixtures, teas of mixed herb contents, mushrooms, poisonous plants, self-harm (e...
October 5, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28971768/a-review-on-phytochemistry-and-pharmacology-of-medicinal-as-well-as-poisonous-mushrooms
#9
Diksha Sharma, Virendra Pratap Singh, Narendra Kumar Singh
Mushrooms have an established history of use in traditional oriental medicine. Higher Basidiomycetes mushrooms contain biologically active compounds in fruit bodies, cultured mycelium, and cultured broth. Medicinal mushrooms possess medicinal properties such as anti-tumor, immunomodulating, antioxidant, cardiovascular, anti-hypercholesterolemic, anti-viral, anti-bacterial, anti-parasitic, anti-fungal, detoxification, hepatoprotective, and anti-diabetic effects. Several compounds isolated from medicinal mushrooms have been subjected to Phase-I, II, and III clinical trials, and are used extensively to treat various diseases including cancer...
September 27, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28905663/epidemiology-and-clinics-of-mushroom-poisoning-in-northern-italy-a-21-year-retrospective-analysis
#10
G Cervellin, I Comelli, G Rastelli, F Sanchis-Gomar, F Negri, C De Luca, G Lippi
BACKGROUND: Limited information exists about epidemiology and management of mushroom poisoning. We analyzed and described epidemiology, clinical presentation, and clinical course of mushroom-poisoned patients admitted to emergency departments (EDs) of the Province of Parma, Italy. METHODS: Data from the database of mycological service were matched with clinical information retrieved from hospitals' database, from January 1, 1996 to December 31, 2016. RESULTS: Mycologist consultation was obtained in 379/443 identified mushroom poisonings...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28895390/a-universal-method-for-the-identification-of-genes-encoding-amatoxins-and-phallotoxins-in-poisonous-mushrooms
#11
Agata Wołoszyn, Roman Kotłowski
Background: As the currently known diagnostic DNA targets amplified in the PCR assays for detection of poisonous mushrooms have their counterparts in edible species, there is a need to design PCR primers specific to the genes encoding amanitins and phallotoxins, which occur only in poisonous mushrooms. Objective: The aim of the study was testing of PCR-based method for detection of all genes encoding hepatotoxic cyclic peptides - amanitins and phallotoxins present in the most dangerous poisonous mushrooms...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28866879/versatility-of-prolyl-oligopeptidase-b-in-peptide-macrocyclization
#12
Robert Michael Sgambelluri, Miranda O Smith, Jonathan D Walton
Cyclic peptides are promising compounds for new chemical biological tools and therapeutics due to their structural diversity, resistance to proteases, and membrane permeability. Amatoxins, the toxic principles of poisonous mushrooms, are biosynthesized on ribosomes as 35-mer precursor peptides which are ultimately converted to hydroxylated bicyclic octapeptides. The initial cyclization steps, catalyzed by a dedicated prolyl oligopeptidase (POPB), involves removal of the 10-amino acid leader sequence from the precursor peptide and transpeptidation to produce a monocyclic octapeptide intermediate...
September 2, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28860534/genomic-and-transcriptomic-analyses-reveal-differential-regulation-of-diverse-terpenoid-and-polyketides-secondary-metabolites-in-hericium-erinaceus
#13
Juan Chen, Xu Zeng, Yan Long Yang, Yong Mei Xing, Qi Zhang, Jia Mei Li, Ke Ma, Hong Wei Liu, Shun Xing Guo
The lion's mane mushroom Hericium erinaceus is a famous traditional medicinal fungus credited with anti-dementia activity and a producer of cyathane diterpenoid natural products (erinacines) useful against nervous system diseases. To date, few studies have explored the biosynthesis of these compounds, although their chemical synthesis is known. Here, we report the first genome and tanscriptome sequence of the medicinal fungus H. erinaceus. The size of the genome is 39.35 Mb, containing 9895 gene models. The genome of H...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28832029/poisoning-deaths-in-poland-types-and-frequencies-reported-in-%C3%A5-%C3%A3-d%C3%A5%C2%BA-krak%C3%A3-w-sosnowiec-gda%C3%A5-sk-wroc%C3%A5-aw-and-pozna%C3%A5-during-2009-2013
#14
Anna Krakowiak, Anna Piekarska-Wijatkowska, Katarzyna Kobza-Sindlewska, Anna Rogaczewska, Piotr Politański, Piotr Hydzik, Beata Szkolnicka, Tomasz Kłopotowski, Sebastian Picheta, Barbara Porębska, Andrzej Antończyk, Wojciech Waldman, Jacek Sein Anand, Eryk Matuszkiewicz, Magdalena Łukasik-Głębocka
OBJECTIVES: The aim of this study has been to assess the characteristics of acute poisoning deaths in Poland over a period of time 2009-2013. MATERIAL AND METHODS: The analysis was based on the data obtained from the patient records stored in toxicology departments in 6 cities - Łódź, Kraków, Sosnowiec, Gdańsk, Wrocław and Poznań. Toxicological analyses were routinely performed in blood and/or urine. Major toxic substances were classified to one of the following categories: pharmaceuticals, alcohol group poisonings (ethanol and other alcohols), gases, solvents, drugs of abuse, pesticides, metals, mushrooms, others...
August 22, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28830736/-evaluation-of-the-toxicity-of-basidiomycota-fungi-on-the-hatching-of-artemia-franciscana-cysts
#15
Luis Eduardo Ruiz-González, Juan Antonio Vázquez-Zea, Fernando Vega-Villasante, Laura Guzmán-Dávalos, Saúl Rogelio Guerrero-Galván
BACKGROUND: The consumption of wild mushrooms has increased in recent years. However, not all mushrooms are edible and some of them may cause poisoning. Therefore, their toxicity needs to be studied. Artemia franciscana is a crustacean used in toxicity tests including toxins of fungi. AIMS: To determine the percentage of inhibition and mortality produced by extracts of several basidiomycetes on the hatching of A. franciscana cysts. METHODS: Aqueous extracts were prepared from 15 species of mushrooms collected from Jalisco state, Mexico...
August 19, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28830233/investigating-and-analyzing-three-cohorts-of-mushroom-poisoning-caused-by-amanita-exitialis-in-yunnan-china
#16
J Sun, H-J Li, H-S Zhang, Y-Z Zhang, J-W Xie, P-B Ma, C Guo, C Y Sun
Amanita exitialis is a lethal mushroom found in China. Knowledge regarding taxonomic characterization, toxin detection, general poisoning conditions, clinical manifestations, laboratory examinations, and clinical treatments for this species is currently lacking. We investigated three A. exitialis mushroom poisoning cohorts in Yunnan Province in 2014 and 2015, involving 10 patients. Mushroom samples were identified by morphological and molecular studies. Ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry was used to detect the peptide toxins in the mushroom samples...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28756828/is-google-trends-a-reliable-tool-for-digital-epidemiology-insights-from-different-clinical-settings
#17
Gianfranco Cervellin, Ivan Comelli, Giuseppe Lippi
Internet-derived information has been recently recognized as a valuable tool for epidemiological investigation. Google Trends, a Google Inc. portal, generates data on geographical and temporal patterns according to specified keywords. The aim of this study was to compare the reliability of Google Trends in different clinical settings, for both common diseases with lower media coverage, and for less common diseases attracting major media coverage. We carried out a search in Google Trends using the keywords "renal colic", "epistaxis", and "mushroom poisoning", selected on the basis of available and reliable epidemiological data...
September 2017: Journal of Epidemiology and Global Health
https://www.readbyqxmd.com/read/28755953/kidney-toxicity-related-to-herbs-and-dietary-supplements-online-table-of-case-reports-part-3-of-5-series
#18
REVIEW
Amy Christine Brown
BACKGROUND: No tabular summary of potentially life-threatening, kidney-toxic dietary supplements (DS; includes herbs) based on PubMed case reports is currently available online and continually updated to forewarn United States consumers, clinicians, and companies manufacturing DS. The purpose of this review was to create an online research summary table of kidney toxicity case reports related to DS. METHODS: Documented PubMed case reports (1966 to May 2016, and cross-referencing) of DS appearing to contribute to kidney toxicity were listed in "DS Toxic Tables...
September 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28690303/pcr-based-method-for-the-detection-of-toxic-mushrooms-causing-food-poisoning-incidents
#19
Chie Nomura, Atsushi Masayama, Mizuka Yamaguchi, Daisuke Sakuma, Keiji Kajimura
In this study, species-specific identification of five toxic mushrooms, Chlorophyllum molybdites, Gymnopilus junonius, Hypholoma fasciculare, Pleurocybella porrigens, and Tricholoma ustale, which have been involved in food-poisoning incidents in Japan, was investigated. Specific primer pairs targeting internal transcribed spacer (ITS) regions were designed for PCR detection. The specific amplicons were obtained from fresh, cooked, and simulated gastric fluid (SGF)-treated samples. No amplicons were detected from other mushrooms with similar morphology...
2017: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/28690301/rapid-identification-method-of-omphalotus-japonicus-by-polymerase-chain-reaction-restriction-fragment-length-polymorphism-pcr-rflp
#20
Yohei Sugano, Kozue Sakata, Kosuke Nakamura, Akio Noguchi, Nozomi Fukuda, Tomohiro Suzuki, Kazunari Kondo
Omphalotus japonicus is a poisonous mushroom that grows in Japan. It can be mistaken for edible mushrooms (Shiitake, Hiratake and Mukitake), and if ingested, it causes food poisoning within 30 min to 1 hr. We established a rapid detection method using PCR-RFLP to identify O. japonicus by restriction digestion of the amplified ITS region. By using Sau96I, Bpu10I, SfcI or DrdI/HincII as a restriction enzyme, it was possible to rapidly identify and discriminate O. japonicus based on the fragment length. This study also provided a short PCR-RFLP system comprising amplification and digestion of a short 200-bp DNA fragment within the ITS region...
2017: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
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