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https://www.readbyqxmd.com/read/28512368/-analysis-of-the-phenomenon-of-over-the-counter-drug-abuse-and-not-controlled-herbs-trade-by-polish-adolescents-part-i
#1
REVIEW
Daria Suchecka, Jolanta Kucharska-Mazur, Katarzyna Groszewska, Monika Mak, Jerzy Samochowiec, Agnieszka Samochowiec
The phenomenon of stupefying by the use of available over-the-counter drugs (OTC) among adolescents is an essential problem in both Poland and throughout the world. Popular analgesics, cold medicine and antihistamines contain psychedelic substances, such as dextromethorphan (DXM), pseudoephedrine/ephedrine, codeine (methylmorphine), dimenhydrinate, paracetamol (acetaminophren) and others. Cases of fatal addiction to dextromethorphan, one of the active substances contained in medicines, e.g., the common cold, have been reported...
May 16, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28399870/the-role-of-traditional-healers-in-the-diagnosis-and-management-of-burkitt-lymphoma-in-cameroon-understanding-the-challenges-and-moving-forward
#2
Glenn M Afungchwi, Peter B Hesseling, Elena J Ladas
BACKGROUND: Burkittlymphoma(BL) is the most common childhood cancer in Cameroon with a reported incidence of 3 per 100,000 children under 15 years in the Northwest region. Treatment at three Baptist mission hospitals has a recorded cure rate of over 50%. Traditional medicine(TM) is recognized by the national health system, but its scope is undefined and entraps children with BL. The aim of this study was to investigate the attitudes and practices of parents and traditional healers (TH) towards TM in children with BL in order to develop recommendations for an integrative approach and improved access to life-saving treatment for children with BL...
April 11, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28372584/long-term-clinical-outcome-for-patients-poisoned-by-the-fungal-nephrotoxin-orellanine
#3
Heidi Hedman, Johan Holmdahl, Johan Mölne, Kerstin Ebefors, Börje Haraldsson, Jenny Nyström
BACKGROUND: Accidental intake of mushrooms of the Cortinarius species (deadly webcap) may cause irreversible renal damage and the need for dialysis or transplantation. The species is found in forests of Northern Europe, Scandinavia and North America and may be mistaken for other edible mushrooms. The highly selective nephrotoxic compound of the mushroom is called orellanine. Very little is known about the long-term effects of the nephrotoxin. METHODS: We identified patients who ingested deadly webcap in the period of 1979 to 2012...
April 3, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28293919/-extracorporeal-liver-support-of-liver-failure
#4
Hans Ulrich Gerth, Michele Pohlen, Hermann Pavenstädt, Hartmut Schmidt
Extracorporeal liver support can be classified into cell-free, artificial methods (artificial liver support, ALS) and cell-based bioartificial methods (bioartificial liver support, BLS). ALS improves biochemical parameters of liver failure by the simultaneous removal of protein-bound and water-soluble substances. Here, the MARS therapy belongs to the most studied methods with a proved beneficial effect on hepatic encephalopathy (HE), hepatorenal syndrome (HRS) or hyperbilirubinemia. However, a general survival advantage of any liver support for liver failure has not been shown yet and is restricted to meta-analyses or patient subgroups...
April 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28286830/mushroom-poisoning-in-the-northeast-of-iran-a-retrospective-6-year-epidemiologic-study
#5
Bita Dadpour, Shahrad Tajoddini, Maliheh Rajabi, Reza Afshari
INTRODUCTION: Toxic mushrooms are distributed across the globe with over 5000 species. Among them, 100 species are responsible for most of the cases of mushroom poisoning. This study aimed to evaluate the epidemiologic pattern of mushroom poisoning among patients referred to the main toxicology center of Mashhad province located in North-east of Iran. METHOD: This cross-sectional study was conducted on patients with final diagnosis of mushroom poisoning referred to the toxicology center of Mashhad, Iran, from February 2005 to 2011...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28284022/trypsin-specific-inhibitors-from-the-macrolepiota-procera-armillaria-mellea-and-amanita-phalloides-wild-mushrooms
#6
Tjaša Lukanc, Jože Brzin, Janko Kos, Jerica Sabotič
Wild growing mushrooms are a rich source of novel proteins with unique features. We have isolated and characterized trypsin inhibitors from two edible mushrooms, the honey fungus (Armillaria mellea) and the parasol mushroom (Macrolepiota procera), and from the poisonous death cap (Amanita phalloides). The trypsin inhibitors isolated: armespin, macrospin and amphaspin, have similar molecular masses, acidic isoelectric points and are not N-glycosylated. They are very strong trypsin inhibitors and weak chymotrypsin inhibitors...
2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/28254004/identification-of-phenolic-compounds-by-liquid-chromatography-mass-spectrometry-in-seventeen-species-of-wild-mushrooms-in-central-mexico-and-determination-of-their-antioxidant-activity-and-bioactive-compounds
#7
Elhadi M Yahia, Fabiola Gutiérrez-Orozco, Marco A Moreno-Pérez
Wild mushrooms are important for the diet of some communities in Mexico. However, limited information exists on their chemical composition, contribution to the diet, and health effects. We characterized seventeen wild mushroom species growing in the state of Queretaro in Central Mexico. Most species analyzed were edible, but also included nonedible, medicinal, poisonous and toxic specimens. Whole mushrooms (caps and stipes) were characterized for water content, color, and total content of phenolic compounds, flavonoids and anthocyanins...
July 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28184019/liver-transplantation-a-life-saving-procedure-following-amatoxin-mushroom-poisoning
#8
K W Ma, K Sh Chok, C K Chan, W C Dai, S L Sin, F L Lau, S C Chan, C M Lo
No abstract text is available yet for this article.
February 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28146341/acute-inocybe-mushroom-toxicosis-in-dogs-5-cases-2010-2014
#9
Kristin Opdal Seljetun, Anita von Krogh
OBJECTIVE: To describe the clinical course, treatment, and outcome of 5 dogs following ingestion of mushrooms belonging to the Inocybe genus. CASE SERIES SUMMARY: Five dogs with witnessed Inocybe ingestions were presented with clinical signs compatible with poisoning. Vomiting, ptyalism, diarrhea, depression, and tachycardia were common clinical findings in the dogs in this case series. The prognosis with Inocybe toxicosis appears to be excellent as all dogs fully recovered following supportive care...
February 1, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28106251/affinity-capillary-electrophoresis-and-quantum-mechanical-calculations-applied-to-investigation-of-gly-6-antamanide-binding-with-sodium-and-potassium-ions
#10
Sachin Pangavhane, Stanislav Böhm, Emanuel Makrlík, Paolo Ruzza, Václav Kašička
Affinity capillary electrophoresis in a free solution (ACE) and quantum mechanical density functional theory (DFT) have been applied to the investigation of interactions of glycine-6-antamanide ([Gly(6) ]AA), a synthetic derivative of cyclic decapeptide antamanide isolated from the highly poisonous mushroom Amanita phalloides, with sodium or potassium ions in methanol. First, from the dependence of effective electrophoretic mobility of [Gly(6) ]AA on Na(+) or K(+) ions concentration in the background electrolyte (BGE) (methanolic solution of 20 mM chloroacetic acid, 10 mM Tris, pHMeOH 7...
January 20, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28073319/no-clinically-relevant-effects-in-children-after-accidental-ingestion-of-panaeolina-foenisecii-lawn-mower-s-mushroom
#11
Katharina M Schenk-Jaeger, Katharina E Hofer-Lentner, Bettina Plenert, Dagmar Eckart, Bettina Haberl, Gabriele Schulze, Janine Borchert-Avalone, Uwe Stedtler, Rudolph Pfab
INTRODUCTION: Panaeolina foenisecii is one of the most common and widely distributed lawn mushrooms in Europe and North America, and frequently involved in accidental mushroom ingestion, mainly in children. Nevertheless, there is contradictory information regarding the toxicity profile of P. foenisecii in the literature. Objective of the study was to assess clinical effects with particular attention on psychoactive properties of P. foenisecii in case of accidental oral exposure. METHODS: This observational case series is based on prospectively collected data on mushroom poisoning using a structured data collection form, and it was performed in seven poisons centres in Germany and Switzerland...
March 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/27988828/mushroom-poisoning-a-retrospective-study-concerning-11-years-of-admissions-in-a-swiss-emergency-department
#12
Maxime Schmutz, Pierre-Nicolas Carron, Bertrand Yersin, Lionel Trueb
Wild mushroom intoxication is an unusual cause of toxic ingestion in Europe. A great diversity of clinical symptoms may arise depending on the variety of wild mushrooms ingested. These initial symptoms are often non-specific, with frequent gastrointestinal symptoms, and have no direct correlation with the outcome. Therefore, management of mushroom poisoning and risk evaluation are a challenge for emergency clinicians. We retrospectively reviewed all cases of mushroom poisoning identified in the ED database spanning 11 years...
December 17, 2016: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/27978833/expansion-and-diversification-of-the-msdin-family-of-cyclic-peptide-genes-in-the-poisonous-agarics-amanita-phalloides-and-a-bisporigera
#13
Jane A Pulman, Kevin L Childs, R Michael Sgambelluri, Jonathan D Walton
BACKGROUND: The cyclic peptide toxins of Amanita mushrooms, such as α-amanitin and phalloidin, are encoded by the "MSDIN" gene family and ribosomally biosynthesized. Based on partial genome sequence and PCR analysis, some members of the MSDIN family were previously identified in Amanita bisporigera, and several other members are known from other species of Amanita. However, the complete complement in any one species, and hence the genetic capacity for these fungi to make cyclic peptides, remains unknown...
December 15, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27910775/hepatoprotective-effects-and-mechanisms-of-action-of-triterpenoids-from-lingzhi-or-reishi-medicinal-mushroom-ganoderma-lucidum-agaricomycetes-on-%C3%AE-amanitin-induced-liver-injury-in-mice
#14
Huihui Wu, Shanshan Tang, Zhaoqin Huang, Qian Zhou, Ping Zhang, Zuohong Chen
Most fatal mushroom poisonings are caused by species of the genus Amanita; the amatoxins are responsible for acute liver failure and death in humans. Ganoderma lucidum is a well-known traditional medicinal mushroom that has been shown to have obvious hepatoprotective effects. This study evaluated the hepatoprotective effects of triterpenoids from G. lucidum on liver injury induced by a-amanitin (α-AMA) in mice and the mechanisms of action of these triterpenoids, including radical scavenging and antiapoptosis activities...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27648562/introducing-mushroom-fruiting-patterns-from-the-swiss-national-poisons-information-centre
#15
Katharina M Schenk-Jäger, Simon Egli, David Hanimann, Beatrice Senn-Irlet, Hugo Kupferschmidt, Ulf Büntgen
Changes in the ecology of macrofungi are poorly understood, not only because much of their life cycle is hidden belowground, but also because experiments often miss real-world complexity and most fruitbody inventories are limited in space and time. The National Poisons Information Centre 'Tox Info Suisse' provides countrywide 24hours/7days medical advice in case of poisonings since 1966. Here, we introduce a total of 12,126 mushroom-related phone calls that were received by Tox Info Suisse between 1966 and 2014...
2016: PloS One
https://www.readbyqxmd.com/read/27538886/psychosis-associated-with-acute-recreational-drug-toxicity-a-european-case-series
#16
Odd Martin Vallersnes, Alison M Dines, David M Wood, Christopher Yates, Fridtjof Heyerdahl, Knut Erik Hovda, Isabelle Giraudon, Paul I Dargan
BACKGROUND: Psychosis can be associated with acute recreational drug and novel psychoactive substance (NPS) toxicity. However, there is limited data available on how common this is and which drugs are most frequently implicated. We describe a European case series of psychosis associated with acute recreational drug toxicity, and estimate the frequency of psychosis for different recreational drugs. METHODS: The European Drug Emergencies Network (Euro-DEN) collects data on presentations to Emergency Departments (EDs) with acute recreational drug and NPS toxicity at 16 centres in ten countries...
August 18, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27506356/rapid-and-reliable-species-identification-of-wild-mushrooms-by-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-maldi-tof-ms
#17
Ryota Sugawara, Sayumi Yamada, Zhihao Tu, Akiko Sugawara, Kousuke Suzuki, Toshihiro Hoshiba, Sadao Eisaka, Akihiro Yamaguchi
Mushrooms are a favourite natural food in many countries. However, some wild species cause food poisoning, sometimes lethal, due to misidentification caused by confusing fruiting bodies similar to those of edible species. The morphological inspection of mycelia, spores and fruiting bodies have been traditionally used for the identification of mushrooms. More recently, DNA sequencing analysis has been successfully applied to mushrooms and to many other species. This study focuses on a simpler and more rapid methodology for the identification of wild mushrooms via protein profiling based on matrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOF MS)...
August 31, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27476461/cyclopeptide-toxins-of-lethal-amanitas-compositions-distribution-and-phylogenetic-implication
#18
Shanshan Tang, Qian Zhou, Zhengmi He, Tao Luo, Ping Zhang, Qing Cai, Zhuliang Yang, Jia Chen, Zuohong Chen
Lethal amanitas (Amanita sect. Phalloideae) are responsible for 90% of all fatal mushroom poisonings. Since 2000, more than ten new lethal Amanita species have been discovered and some of them had caused severe mushroom poisonings in China. However, the contents and distribution of cyclopeptides in these lethal mushrooms remain poorly known. In this study, the diversity of major cyclopeptide toxins in seven Amanita species from Eastern Asia and three species from Europe and North America were systematically analyzed, and a new approach to inferring phylogenetic relationships using cyclopeptide profile was evaluated for the first time...
September 15, 2016: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/27394089/fabrication-of-a-biomimetic-adsorbent-imprinted-with-a-common-specificity-determinant-for-the-removal-of-%C3%AE-and-%C3%AE-amanitin-from-plasma
#19
Lei Tan, Rong He, Yongxian Li, Yong Liang, He Li, Youwen Tang
α-Amanitin and β-amanitin are the main toxins of mushroom poisoning. The application of traditional non-selective adsorbents is not satisfactory in clinical treatment of amanita mushroom poisoning due to lack of specificity adsorption capability of these adsorbents toward amanitin toxins. In the current work, we introduce a novel molecularly imprinted biomimetic adsorbent based on a ligand specificity determinant through surface imprinted strategy. Owing to the expensive price of the amanitin sources, we selected a typical common moiety of α, β-amanitin as specificity determinant to synthesize a template necessary for the preparation of molecularly imprinted polymers (MIPs)...
August 12, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27366018/a-case-of-mushroom-poisoning-with-russula-subnigricans-development-of-rhabdomyolysis-acute-kidney-injury-cardiogenic-shock-and-death
#20
Jong Tae Cho, Jin Hyung Han
Mushroom exposures are increasing worldwide. The incidence and fatality of mushroom poisoning are reported to be increasing. Several new syndromes in mushroom poisoning have been described. Rhabdomyolytic mushroom poisoning is one of new syndromes. Russula subnigricans mushroom can cause delayed-onset rhabdomyolysis with acute kidney injury in the severely poisoned patient. There are few reports on the toxicity of R. subnigricans. This report represents the first record of R. subnigricans poisoning with rhabdomyolysis in Korea, describing a 51-year-old man who suffered from rhabdomyolysis, acute kidney injury, severe hypocalcemia, respiratory failure, ventricular tachycardia, cardiogenic shock, and death...
July 2016: Journal of Korean Medical Science
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