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https://www.readbyqxmd.com/read/29351371/implementation-of-standardized-clinical-processes-for-tpmt-testing-in-a-diverse-multidisciplinary-population-challenges-and-lessons-learned
#1
Kristin W Weitzel, D Max Smith, Amanda R Elsey, Benjamin Q Duong, Benjamin Burkley, Michael Clare-Salzler, Yan Gong, Tara A Higgins, Benjamin Kong, Taimour Langaee, Caitrin W McDonough, Benjamin J Staley, Teresa T Vo, Dyson T Wake, Larisa H Cavallari, Julie A Johnson
Although thiopurine S-methyltransferase (TPMT) genotyping to guide thiopurine dosing is common in the pediatric cancer population, limited data exist on TPMT testing implementation in diverse, multidisciplinary settings. We established TPMT testing (genotype and enzyme) with clinical decision support, provider/patient education, and pharmacist consultations in a tertiary medical center and collected data over 3 years. During this time, 834 patients underwent 873 TPMT tests (147 (17%) genotype, 726 (83%) enzyme)...
January 19, 2018: Clinical and Translational Science
https://www.readbyqxmd.com/read/29350974/use-of-simulation-based-training-to-aid-in-implementing-complex-health-technology
#2
Veffa Devers
Clinicians are adult learners in a complex environment that historically does not invest in training in a way that is conducive to these types of learners. Adult learners are independent, self-directed, and goal oriented. In today's fast-paced clinical setting, a practical need exists for nurses and clinicians to master the technology they use on a daily basis, especially as medical devices have become more interconnected and complex. As hospitals look to embrace new technologies, medical device companies must provide clinical end-user training...
January 2018: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/29350542/preliminary-investigation-of-social-interactions-and-feeding-behavior-in-captive-group-housed-tasmanian-devils-sarcophilus-harrisii
#3
Candice J A Skelton, Hayley J Stannard
As the number of Tasmanian devils (Sarcophilus harrisii) in captivity increases, an understanding of captive social dynamics and behavior is becoming increasingly important. In the wild, devils are solitary, although sometimes, they congregate to feed on a large carcass. However, it is common to house devils in groups as a form of social enrichment. This study investigated how behavior at feeding time of captive Tasmanian devils varied in groups of different sizes. Observations were made of individually housed devils and devils in groups of two, three, five, and six, when presented with a carcass on which to feed...
January 19, 2018: Journal of Applied Animal Welfare Science: JAAWS
https://www.readbyqxmd.com/read/29346308/tissue-engineering-to-improve-immature-testicular-tissue-and-cell-transplantation-outcomes-one-step-closer-to-fertility-restoration-for-prepubertal-boys-exposed-to-gonadotoxic-treatments
#4
REVIEW
Federico Del Vento, Maxime Vermeulen, Francesca de Michele, Maria Grazia Giudice, Jonathan Poels, Anne des Rieux, Christine Wyns
Despite their important contribution to the cure of both oncological and benign diseases, gonadotoxic therapies present the risk of a severe impairment of fertility. Sperm cryopreservation is not an option to preserve prepubertal boys' reproductive potential, as their seminiferous tubules only contain spermatogonial stem cells (as diploid precursors of spermatozoa). Cryobanking of human immature testicular tissue (ITT) prior to gonadotoxic therapies is an accepted practice. Evaluation of cryopreserved ITT using xenotransplantation in nude mice showed the survival of a limited proportion of spermatogonia and their ability to proliferate and initiate differentiation...
January 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29346302/smart-device-based-notifications-to-promote-healthy-behavior-related-to-childhood-obesity-and-overweight
#5
Gustavo López, Iván González, Elitania Jimenez-Garcia, Jesús Fontecha, Jose A Brenes, Luis A Guerrero, José Bravo
Obesity is one of the most serious public health challenges of the 21st century and it is a threat to the life of people according to World Health Organization. In this scenario, family environment is important to establish healthy habits which help to reduce levels of obesity and control overweight in children. However, little efforts have been focused on helping parents to promote and have healthy lifestyles. In this paper, we present two smart device-based notification prototypes to promote healthy behavior with the aim of avoiding childhood overweight and obesity...
January 18, 2018: Sensors
https://www.readbyqxmd.com/read/29345224/therapy-interventions-for-children-with-neurodisabilities-a-qualitative-scoping-study
#6
Bryony Beresford, Susan Clarke, Jane Maddison
BACKGROUND: Therapy interventions emerged four times in the top 10 research priorities in a James Lind Alliance research prioritisation exercise for children with neurodisabilities (Morris C, Simkiss D, Busk M, Morris M, Allard A, Denness J, et al. Setting research priorities to improve the health of children and young people with neurodisability: a British Academy of Childhood Disability-James Lind Alliance Research Priority Setting Partnership. BMJ Open 2015;5:e006233). The National Institute for Health Research (NIHR) commissioned this study as part of an information-gathering exercise in response to this...
January 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29344002/the-journey-from-clinician-to-undergraduate-medical-educator-involves-four-patterns-of-transformation
#7
Efrain Riveros-Perez, Jorge Rodriguez-Diaz
Objectives: Traditionally, teaching is part of a clinician's job. Some practitioners recognize the teaching activity as rewarding. This study explored the ways clinical practitioners experience their journey from clinicians to medical teachers, analyzing their prior experiences of teaching and learning, conceptions of good teaching and learning, perceptions of learning environments, and finally, how those factors influence their approaches to teaching. Methods: Data for phenomenographic analysis were collected through semi-structured interviews conducted in Spanish and administered to twelve clinical teachers in three medical schools in Colombia...
2018: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/29342272/daily-decision-making-about-food-during-pregnancy-a-new-zealand-study
#8
Susan Pullon, Angela Ballantyne, Lindsay Macdonald, Christine Barthow, Kristin Wickens, Julian Crane
Pregnancy has always been a life-changing event for women and their families, but societal concern about pregnancy and motherhood has become intense in the digital age. The role of health promotion agencies and others supplying health-related resources about lifestyle behaviours is both important and in need of scrutiny. Ever increasing advice for pregnant women, their families and health professionals, abounds. This study of decision making during pregnancy investigated how women made everyday decisions during pregnancy about food and drink, as well as dietary supplements and medications, alcohol and recreational drugs...
January 12, 2018: Health Promotion International
https://www.readbyqxmd.com/read/29341818/medicine-as-it-should-be-teaching-team-and-teamwork-during-a-palliative-care-clerkship
#9
Barbara A Head, Christian Davis Furman, Andrew M Lally, Kimberly Leake, Mark Pfeifer
BACKGROUND: Interprofessional Education (IPE) is an important component of medical education. Rotations with palliative care interdisciplinary teams (IDTs) provide an optimal environment for IPE and teaching teamwork skills. OBJECTIVE: Our objective was to assess the learning of senior medical students during a palliative care rotation. DESIGN: A constant comparison method based on grounded theory was used in this qualitative study. SETTING/SUBJECTS: Senior medical students completed a semi-structured reflective writing exercise after a required one-week palliative care clerkship...
January 17, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29341812/optional-anatomy-and-physiology-e-learning-resources-student-access-learning-approaches-and-academic-outcomes
#10
Richard Guy, Bruce Byrne, Marian Dobos
Anatomy and physiology interactive video clips were introduced into a blended learning environment, as an optional resource, and were accessed by ~50% of the cohort. Student feedback indicated that clips were engaging, assisted understanding of course content, and provided lecture support. Students could also access two other optional online resources, lecture capture recordings and an interactive atlas of anatomy, and individuals were tracked with respect to their access behavior, learning approach, and subject score...
March 1, 2018: Advances in Physiology Education
https://www.readbyqxmd.com/read/29340725/decision-making-in-management-of-the-complex-trauma-patient-changing-the-mindset-of-the-non-trauma-surgeon
#11
Linda Sonesson, Kenneth Boffard, Lars Lundberg, Martin Rydmark, Klas Karlgren
BACKGROUND: European surgeons are frequently subspecialized and trained primarily in elective surgical techniques. As trauma leaders, they may occasionally have to deal with complex polytrauma, advanced management techniques, differing priorities, and the need for multidisciplinary care. There is a lack of expertise, experience, and a low trauma volume, as well as a lack of research, with limited support as to the decision-making and teaching challenges present. We studied what experienced trauma experts describe as the challenges that are specific to the advanced surgical decision-making required, whether civilian, humanitarian, or military...
January 16, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29339414/assembly-of-methyl-coenzyme-m-reductase-in-the-methanogenic-archaeon-methanococcus-maripaludis
#12
Zhe Lyu, Chau-Wen Chou, Hao Shi, Liangliang Wang, Robel Ghebreab, Dennis Phillips, Yajun Yan, Evert C Duin, William B Whitman
Methyl-coenzyme M reductase (MCR) is a complex enzyme that catalyzes the final step in biological methanogenesis. To better understand its assembly, the recombinant MCR from the thermophile Methanothermococcus okinawensis (rMCRok) was expressed in the mesophile Methanococcus maripaludis The rMCRok was post-translationally modified correctly and contained McrD and the unique nickel tetrapyrrole coenzyme F430 Subunits of the native M. maripaludis (MCRmar) were largely absent, suggesting that the recombinant enzyme was formed by an assembly of co-transcribed subunits...
January 16, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29337282/comparative-proteome-analysis-of-monolayer-and-spheroid-culture-of-canine-osteosarcoma-cells
#13
Christiane Gebhard, Ingrid Miller, Karin Hummel, Martina Neschi Née Ondrovics, Sarah Schlosser, Ingrid Walter
Osteosarcoma is an aggressive bone tumor with high metastasis rate in the lungs and affects both humans and dogs in a similar way. Three-dimensional tumor cell cultures mimic the in vivo situation of micro-tumors and metastases and are therefore better experimental in vitro models than the often applied two-dimensional monolayer cultures. The aim of the present study was to perform comparative proteomics of standard monolayer cultures of canine osteosarcoma cells (D17) and three-dimensional spheroid cultures, to better characterize the 3D model before starting with experiments like migration assays...
January 11, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29336695/-ghosts-from-the-past-the-re-emergence-of-internalised-religious-stigma-following-diagnosis-of-hiv-among-northern-irish-gay-men
#14
Keith Kerrigan, Gill Green
This paper explores how previous exposure to religious homo-negativity features in the sense making process following HIV diagnosis in a homogenous sample of six gay men living in Northern Ireland. Interpretive Phenomenological Analysis was used to identify two key overarching themes: 'Negotiating authenticity in unsafe space' which relates to the experience of negotiating same sex attraction within religious environments and 'Re-emergence of religious shame in diagnosis' which relates to the way in which the men made sense of diagnosis from the position of having been exposed to religious homo-negativity earlier in their lives...
January 16, 2018: Journal of Homosexuality
https://www.readbyqxmd.com/read/29336236/implementation-of-genomics-research-in-africa-challenges-and-recommendations
#15
Sally N Adebamowo, Veronica Francis, Ernest Tambo, Seybou H Diallo, Guida Landouré, Victoria Nembaware, Eileen Dareng, Babu Muhamed, Michael Odutola, Teniola Akeredolu, Barbara Nerima, Petronilla J Ozumba, Slee Mbhele, Anita Ghanash, Ablo P Wachinou, Nicholas Ngomi
BACKGROUND: There is exponential growth in the interest and implementation of genomics research in Africa. This growth has been facilitated by the Human Hereditary and Health in Africa (H3Africa) initiative, which aims to promote a contemporary research approach to the study of genomics and environmental determinants of common diseases in African populations. OBJECTIVE: The purpose of this article is to describe important challenges affecting genomics research implementation in Africa...
2018: Global Health Action
https://www.readbyqxmd.com/read/29334935/adoption-and-diffusion-of-zoning-bylaws-banning-fast-food-drive-through-services-across-canadian-municipalities
#16
Candace I J Nykiforuk, Elizabeth J Campbell, Soultana Macridis, Daniel McKennitt, Kayla Atkey, Kim D Raine
BACKGROUND: Healthy public policy is an important tool for creating environments that support human health and wellbeing. At the local level, municipal policies, such as zoning bylaws, provide an opportunity for governments to regulate building location and the type of services offered. Across North America, there has been a recent proliferation of municipal bylaws banning fast food drive-through services. Research on the utilization of this policy strategy, including bylaw adopters and adopter characteristics, is limited within the Canadian context...
January 15, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29334421/a-survey-of-tooth-morphology-teaching-methods-employed-in-the-united-kingdom-and-ireland
#17
M Lone, J P McKenna, J F Cryan, E J Downer, A Toulouse
BACKGROUND: Tooth morphology is a central component of the dental curriculum and is applicable to all dental specialities. Traditional teaching methods are being supplemented with innovative strategies to tailor teaching and accommodate the learning styles of the recent generation of students. METHODS: An online survey was compiled and distributed to the staff involved in teaching tooth morphology in the United Kingdom and Ireland to assess the importance of tooth morphology in the dentistry curriculum and the methodologies employed in teaching...
January 15, 2018: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/29334324/the-rite-of-passage-of-becoming-a-humanitarian-health-worker-experiences-of-retention-in-sweden
#18
Sara Albuquerque, Anneli Eriksson, Helle M Alvesson
BACKGROUND: Low retention of humanitarian workers poses constraints on humanitarian organisations' capacity to respond effectively to disasters. Research has focused on reasons for humanitarian workers leaving the sector, but little is known about the factors that can elucidate long-term commitment. OBJECTIVE: To understand what motivates and supports experienced humanitarian health workers to remain in the sector. METHODS: Semi-structured interviews were conducted with 10 experienced nurses who had been on at least three field missions with Médecins Sans Frontières Sweden...
2018: Global Health Action
https://www.readbyqxmd.com/read/29333328/learning-tree-structured-detection-cascades-for-heterogeneous-networks-of-embedded-devices
#19
Hamid Dadkhahi, Benjamin M Marlin
In this paper, we present a new approach to learning cascaded classifiers for use in computing environments that involve networks of heterogeneous and resource-constrained, low-power embedded compute and sensing nodes. We present a generalization of the classical linear detection cascade to the case of tree-structured cascades where different branches of the tree execute on different physical compute nodes in the network. Different nodes have access to different features, as well as access to potentially different computation and energy resources...
August 2017: KDD: Proceedings
https://www.readbyqxmd.com/read/29333059/innate-food-aversions-and-culturally-transmitted-food-taboos-in-pregnant-women-in-rural-southwest-india-separate-systems-to-protect-the-fetus
#20
Caitlyn D Placek, Purnima Madhivanan, Edward H Hagen
Pregnancy increases women's nutritional requirements, yet causes aversions to nutritious foods. Most societies further restrict pregnant women's diet with food taboos. Pregnancy food aversions are theorized to protect mothers and fetuses from teratogens and pathogens or increase dietary diversity in response to resource scarcity. Tests of these hypotheses have had mixed results, perhaps because many studies are in Westernized populations with reliable access to food and low exposure to pathogens. If pregnancy food aversions are adaptations, however, then they likely evolved in environments with uncertain access to food and high exposure to pathogens...
November 2017: Evolution and Human Behavior: Official Journal of the Human Behavior and Evolution Society
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