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brown adipogenesis

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https://www.readbyqxmd.com/read/29775611/reduced-adiposity-by-compensatory-wat-browning-upon-ibat-removal-in-mice
#1
Zhengyu Piao, Baiqiang Zhai, Xiaoxiao Jiang, Meng Dong, Changguo Yan, Jun Lin, Wanzhu Jin
The strong effects of classic brown adipose tissue (BAT) and recruited beige adipocytes in treatment of obesity and metabolic syndrome have been attracting increasing research interest. Cold treatment is an effective, convenient approach to stimulate BAT activity and induce white adipose tissue (WAT) browning. Here, we utilized prolonged cold exposure (from 2 h to 2 weeks in a 4° cold chamber) to elucidate dynamic changes in BAT and in WAT browning during acute and chronic cold exposure in mice. BAT mass decreased quickly, with reduced lipid droplet sizes within 8 h of cold exposure owing to the utilization of BAT pre-storage triglycerides, and subsequently increased during prolonged cold exposure...
May 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29764980/interplay-of-cell-cell-contacts-and-rhoa-mrtf-a-signaling-regulates-cardiomyocyte-identity
#2
Tatjana Dorn, Jessica Kornherr, Elvira I Parrotta, Dorota Zawada, Harold Ayetey, Gianluca Santamaria, Laura Iop, Elisa Mastantuono, Daniel Sinnecker, Alexander Goedel, Ralf J Dirschinger, Ilaria My, Svenja Laue, Tarik Bozoglu, Christian Baarlink, Tilman Ziegler, Elisabeth Graf, Rabea Hinkel, Giovanni Cuda, Stefan Kääb, Andrew A Grace, Robert Grosse, Christian Kupatt, Thomas Meitinger, Austin G Smith, Karl-Ludwig Laugwitz, Alessandra Moretti
Cell-cell and cell-matrix interactions guide organ development and homeostasis by controlling lineage specification and maintenance, but the underlying molecular principles are largely unknown. Here, we show that in human developing cardiomyocytes cell-cell contacts at the intercalated disk connect to remodeling of the actin cytoskeleton by regulating the RhoA-ROCK signaling to maintain an active MRTF/SRF transcriptional program essential for cardiomyocyte identity. Genetic perturbation of this mechanosensory pathway activates an ectopic fat gene program during cardiomyocyte differentiation, which ultimately primes the cells to switch to the brown/beige adipocyte lineage in response to adipogenesis-inducing signals...
May 15, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29753771/mir-199a-3p-regulates-brown-adipocyte-differentiation-through-mtor-signaling-pathway
#3
Yao Gao, Yan Cao, Xianwei Cui, Xingyun Wang, Yahui Zhou, Fangyan Huang, Xing Wang, Juan Wen, Kaipeng Xie, Pengfei Xu, Xirong Guo, Lianghui You, Chenbo Ji
Recent discoveries of functional brown adipocytes in mammals illuminates their therapeutic potential for combating obesity and its associated diseases. However, on account of the limited amount and activity in adult humans of brown adipocyte depots, identification of miRNAs and characterization their regulatory roles in human brown adipogenesis are urgently needed. This study focused on the role of microRNA (miR)-199a-3p in human brown adipocyte differentiation and thermogenic capacity. A decreased expression pattern of miR-199a-3p was consistently observed during the differentiation course of brown adipocytes in mice and humans...
May 10, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29744695/bovine-lactoferrin-promotes-energy-expenditure-via-the-camp-pka-signaling-pathway-in-human-reprogrammed-brown-adipocytes
#4
Kanae Nakamura, Tsunao Kishida, Akika Ejima, Riho Tateyama, Satoru Morishita, Tomoji Ono, Michiaki Murakoshi, Keikichi Sugiyama, Hoyoku Nishino, Osam Mazda
Lactoferrin (LF) is a multifunctional protein in mammalian milk. We previously reported that enteric-coated bovine LF reduced the visceral fat in a double-blind clinical study. We further demonstrated that bovine LF (bLF) inhibited adipogenesis and promoted lipolysis in white adipocytes, but the effect of bLF on brown adipocytes has not been clarified. In this study, we investigated the effects of bLF on energy expenditure and cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling pathway using human reprogrammed brown adipocytes generated by gene transduction...
May 9, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29728617/depletion-of-nsd2-mediated-histone-h3k36-methylation-impairs-adipose-tissue-development-and-function
#5
Lenan Zhuang, Younghoon Jang, Young-Kwon Park, Ji-Eun Lee, Shalini Jain, Eugene Froimchuk, Aaron Broun, Chengyu Liu, Oksana Gavrilova, Kai Ge
The epigenetic mechanisms regulating adipose tissue development and function are poorly understood. In this study, we show that depletion of histone H3K36 methylation by H3.3K36M in preadipocytes inhibits adipogenesis by increasing H3K27me3 to prevent the induction of C/EBPα and other targets of the master adipogenic transcription factor peroxisome proliferator-activated receptor-γ (PPARγ). Depleting H3K36 methyltransferase Nsd2, but not Nsd1 or Setd2, phenocopies the effects of H3.3K36M on adipogenesis and PPARγ target expression...
May 4, 2018: Nature Communications
https://www.readbyqxmd.com/read/29710033/methylxanthine-derivative-rich-cacao-extract-suppresses-differentiation-of-adipocytes-through-downregulation-of-ppar%C3%AE-and-c-ebps
#6
Yoko Yamashita, Takakazu Mitani, Liuqing Wang, Hitoshi Ashida
Cacao extract (CE) consumption has beneficial effects on human health, such as lowering the risk of obesity. However, the underlying molecular mechanism for the anti-obesity effect of CE remains incompletely understood. Here, we used a 50% aqueous alcohol extract of cacao mass, which is rich in methylxanthine derivatives (about 11%) and poor in flavan-3-ols (less than 1%), and assessed the suppression effects of this extract on adipocyte differentiation to investigate the anti-obesity mechanism. CE dose-dependently decreased fat accumulation in 3T3-L1 cells without affecting cell viability...
2018: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29692363/jak-tgf%C3%AE-cross-talk-links-transient-adipose-tissue-inflammation-to-beige-adipogenesis
#7
Rohollah Babaei, Maximilian Schuster, Irina Meln, Sarah Lerch, Rayane A Ghandour, Didier F Pisani, Irem Bayindir-Buchhalter, Julia Marx, Shuang Wu, Gabriele Schoiswohl, Adrian T Billeter, Damir Krunic, Jan Mauer, Yun-Hee Lee, James G Granneman, Lars Fischer, Beat P Müller-Stich, Ez-Zoubir Amri, Erin E Kershaw, Mathias Heikenwälder, Stephan Herzig, Alexandros Vegiopoulos
The transient activation of inflammatory networks is required for adipose tissue remodeling including the "browning" of white fat in response to stimuli such as β3-adrenergic receptor activation. In this process, white adipose tissue acquires thermogenic characteristics through the recruitment of so-called beige adipocytes. We investigated the downstream signaling pathways impinging on adipocyte progenitors that promote de novo formation of adipocytes. We showed that the Jak family of kinases controlled TGFβ signaling in the adipose tissue microenvironment through Stat3 and thereby adipogenic commitment, a function that was required for beige adipocyte differentiation of murine and human progenitors...
April 24, 2018: Science Signaling
https://www.readbyqxmd.com/read/29687381/decellularized-adipose-tissue-scaffolds-for-soft-tissue-regeneration-and-adipose-derived-stem-stromal-cell-delivery
#8
Pascal Morissette Martin, Arthi Shridhar, Claire Yu, Cody Brown, Lauren E Flynn
Surgically discarded adipose tissue is not only an abundant source of multipotent adipose-derived stem/stromal cells (ASCs) but can also be decellularized to obtain a biomimetic microenvironment for tissue engineering applications. The decellularization methods involve processing excised fat through a series of chemical, mechanical, and enzymatic treatment stages designed to extract cells, cellular components, and lipid from the tissues. This process yields a complex 3D bioscaffold enriched in collagens that mimics the biochemical and biomechanical properties of the native extracellular matrix (ECM)...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29683137/erratum-author-correction-angiotensin-type-2-receptor-activation-promotes-browning-of-white-adipose-tissue-and-brown-adipogenesis
#9
Aung Than, Shaohai Xu, Ru Li, Melvin Khee-Shing Leow, Lei Sun, Peng Chen
[This corrects the article DOI: 10.1038/sigtrans.2017.22.].
2018: Signal Transduction and Targeted Therapy
https://www.readbyqxmd.com/read/29674659/histone-demethylase-jmjd1a-coordinates-acute-and-chronic-adaptation-to-cold-stress-via-thermogenic-phospho-switch
#10
Yohei Abe, Yosuke Fujiwara, Hiroki Takahashi, Yoshihiro Matsumura, Tomonobu Sawada, Shuying Jiang, Ryo Nakaki, Aoi Uchida, Noriko Nagao, Makoto Naito, Shingo Kajimura, Hiroshi Kimura, Timothy F Osborne, Hiroyuki Aburatani, Tatsuhiko Kodama, Takeshi Inagaki, Juro Sakai
In acute cold stress in mammals, JMJD1A, a histone H3 lysine 9 (H3K9) demethylase, upregulates thermogenic gene expressions through β-adrenergic signaling in brown adipose tissue (BAT). Aside BAT-driven thermogenesis, mammals have another mechanism to cope with long-term cold stress by inducing the browning of the subcutaneous white adipose tissue (scWAT). Here, we show that this occurs through a two-step process that requires both β-adrenergic-dependent phosphorylation of S265 and demethylation of H3K9me2 by JMJD1A...
April 19, 2018: Nature Communications
https://www.readbyqxmd.com/read/29667012/bone-marrow-adipocyte-developmental-origin-and-biology
#11
REVIEW
Joanna Bukowska, Trivia Frazier, Stanley Smith, Theodore Brown, Robert Bender, Michelle McCarthy, Xiying Wu, Bruce A Bunnell, Jeffrey M Gimble
PURPOSE OF REVIEW: This review explores how the relationships between bone marrow adipose tissue (BMAT) adipogenesis with advancing age, obesity, and/or bone diseases (osteopenia or osteoporosis) contribute to mechanisms underlying musculoskeletal pathophysiology. RECENT FINDINGS: Recent studies have re-defined adipose tissue as a dynamic, vital organ with functions extending beyond its historic identity restricted solely to that of an energy reservoir or sink. "State of the art" methodologies provide novel insights into the developmental origin, physiology, and function of different adipose tissue depots...
April 18, 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29626186/de-novo-reconstruction-of-human-adipose-transcriptome-reveals-conserved-lncrnas-as-regulators-of-brown-adipogenesis
#12
Chunming Ding, Yen Ching Lim, Sook Yoong Chia, Arcinas Camille Esther Walet, Shaohai Xu, Kinyui Alice Lo, Yanling Zhao, Dewen Zhu, Zhihui Shan, Qingfeng Chen, Melvin Khee-Shing Leow, Dan Xu, Lei Sun
Obesity has emerged as an alarming health crisis due to its association with metabolic risk factors such as diabetes, dyslipidemia, and hypertension. Recent work has demonstrated the multifaceted roles of lncRNAs in regulating mouse adipose development, but their implication in human adipocytes remains largely unknown. Here we present a catalog of 3149 adipose active lncRNAs, of which 909 are specifically detected in brown adipose tissue (BAT) by performing deep RNA-seq on adult subcutaneous, omental white adipose tissue and fetal BATs...
April 6, 2018: Nature Communications
https://www.readbyqxmd.com/read/29614883/bergamottin-inhibits-adipogenesis-in-3t3-l1-cells-and-weight-regulation-in-diet-induced-obese-mice
#13
Jeong-Hyeon Ko, Dongwoo Nam, Jae-Young Um, Sang Hoon Jung, Kwang Seok Ahn
Obesity is a serious and increasing health problem worldwide, and the inhibition of adipogenesis is considered to be a potential therapeutic target for it. Bergamottin (BGM), a component of grapefruit juice, has been reported to regulate lipolysis. However, the physiological role of BGM in obesity has not been evaluated so far. In the present study, we investigated the effects of BGM on obesity in 3T3-L1 cells and in mice fed a high-fat diet (HFD). BGM inhibited adipogenic differentiation of 3T3-L1 cells along with a significant decrease in the lipid content by downregulating the expression of two critical adipogenic factors, CCAAT enhancer-binding protein-alpha (C/EBP[Formula: see text]) and peroxisome proliferator activated receptor-gamma (PPAR[Formula: see text])...
April 4, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29605715/a-computational-biology-approach-of-a-genome-wide-screen-connected-mirnas-to-obesity-and-type-2-diabetes
#14
Pascal Gottmann, Meriem Ouni, Sophie Sausenthaler, Julian Roos, Laura Stirm, Markus Jähnert, Anne Kamitz, Nicole Hallahan, Wenke Jonas, Andreas Fritsche, Hans-Ulrich Häring, Harald Staiger, Matthias Blüher, Pamela Fischer-Posovszky, Heike Vogel, Annette Schürmann
OBJECTIVE: Obesity and type 2 diabetes (T2D) arise from the interplay between genetic, epigenetic, and environmental factors. The aim of this study was to combine bioinformatics and functional studies to identify miRNAs that contribute to obesity and T2D. METHODS: A computational framework (miR-QTL-Scan) was applied by combining QTL, miRNA prediction, and transcriptomics in order to enhance the power for the discovery of miRNAs as regulative elements. Expression of several miRNAs was analyzed in human adipose tissue and blood cells and miR-31 was manipulated in a human fat cell line...
March 15, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29593245/evaluation-and-optimization-of-differentiation-conditions-for-human-primary-brown-adipocytes
#15
XingYun Wang, LiangHui You, XianWei Cui, Yun Li, Xing Wang, PengFei Xu, LiJun Zhu, Juan Wen, LingXia Pang, XiRong Guo, ChenBo Ji
As an effective way to improve energy expenditure, increasing the mass and activity of brown adipose tissue (BAT) has become a promising treatment for obesity and its associated disorders. Many efforts have been made to promote brown adipogenesis and increase the thermogenic capacity of brown adipose cells (BACs). The present culture schemes for human BAC differentiation are mostly derived from white adipocyte differentiation schemes. To solve this issue, we compared the adipogenic and thermogenic effects of various components on human BAC differentiation and optimized their concentrations as well as the culture time for BAC differentiation...
March 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29579167/glucocorticoid-receptor-signaling-is-not-required-for-in-vivo-adipogenesis
#16
Kevin T Bauerle, Irina Hutson, Erica L Scheller, Charles A Harris
Regulation of adipogenesis is of significant interest given that adipose tissue expansion and dysfunction are central to metabolic syndrome. Glucocorticoids (GCs) are important for adipogenesis in vitro. However, a role for GCs in adipogenesis in vivo has been difficult to establish. Glucocorticoid receptor (GR)-null mice die at birth, a time at which wild-type mice do not have fully developed white adipose depots. We have conducted several studies aimed at defining the role of GC signaling in adipogenesis in vitro and in vivo...
March 19, 2018: Endocrinology
https://www.readbyqxmd.com/read/29577045/pycnogenol%C3%A2-induces-browning-of-white-adipose-tissue-through-the-pka-signaling-pathway-in-apolipoprotein-e-deficient-mice
#17
Huiying Cong, Wenxia Zhong, Yiying Wang, Shoichiro Ikuyama, Bin Fan, Jianqiu Gu
Beige adipocytes in white adipose tissue (WAT) have received considerable recognition because of their potential protective effect against obesity. Pycnogenol (PYC), extracted from French maritime pine bark, has anti-inflammatory and antioxidant properties and can improve lipid profiles. However, the effect of PYC on obesity has never been explored. In this study, we investigated the effects of PYC on obesity and WAT browning in apolipoprotein E- (ApoE-) deficient mice. The results showed that PYC treatment clearly reversed body weight and the mass of eWAT gain resulting from a high-cholesterol and high-fat diet (HCD), but no difference in food intake...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29555462/effects-of-tunable-3d-bioprinted-hydrogels-on-human-brown-adipocyte-behavior-and-metabolic-function
#18
Mitchell Kuss, Jiyoung Kim, Dianjun Qi, Shaohua Wu, Yuguo Lei, Soonkyu Chung, Bin Duan
Obesity and its related health complications cause billions of dollars in healthcare costs annually in the United States, and there are yet to be safe and long-lasting anti-obesity approaches. Using brown adipose tissue (BAT) is a promising approach, as it uses fats for energy expenditure. However, the effect of the microenvironment on human thermogenic brown adipogenesis and how to generate clinically relevant sized and functioning BAT are still unknown. In our current study, we evaluated the effects of endothelial growth medium exposure on brown adipogenesis of human brown adipose progenitors (BAP)...
March 16, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29522452/milk-fat-globule-membrane-attenuates-high-fat-diet-induced-obesity-by-inhibiting-adipogenesis-and-increasing-uncoupling-protein-1-expression-in-white-adipose-tissue-of-mice
#19
Tiange Li, Jing Gao, Min Du, Jiajia Song, Xueying Mao
Milk fat globule membrane (MFGM), a protein-lipid complex surrounding the fat globules in milk, has many health benefits. The aim of the current study was to investigate whether MFGM could prevent obesity through inhibiting adipogenesis and promoting brown remodeling of white adipose tissue (WAT) in mice fed with high-fat diet. C57BL/6 mice were fed a normal diet (ND), high-fat diet (HFD), HFD plus MFGM at 100 mg/kg BW, 200 mg/kg BW or 400 mg/kg BW for 8 weeks. Results showed that MFGM suppressed body weight gain induced by HFD, reduced white adipose tissue (WAT) mass accompanied with the decrease in adipocyte sizes...
March 9, 2018: Nutrients
https://www.readbyqxmd.com/read/29519872/adipocyte-long-noncoding-rna-transcriptome-analysis-of-obese-mice-identified-lnc-leptin-which-regulates-leptin
#20
Kinyui Alice Lo, Shiqi Huang, Arcinas Camille Esther Walet, Zhi-Chun Zhang, Melvin Khee-Shing Leow, Meihui Liu, Lei Sun
Obesity induces profound transcriptome changes in adipocytes; recent evidence suggests that lncRNAs play key roles in this process. Here, we performed a comprehensive transcriptome study by RNA-Seq in adipocytes isolated from interscapular brown, inguinal and epididymal white adipose tissues in diet-induced obese mice. Our analysis reveals a set of obesity-dysregulated lncRNAs, many of which exhibit dynamic changes in fed vs. fasted state, potentially serving as novel molecular markers reflecting adipose energy status...
March 8, 2018: Diabetes
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