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Thyroid hormone replacement

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https://www.readbyqxmd.com/read/29444549/body-weight-change-is-unpredictable-after-total-thyroidectomy
#1
Ron Glick, Paula Chang, Peter Michail, Jonathan W Serpell, Simon Grodski, James C Lee
BACKGROUND: There is a common perception that total thyroidectomy causes weight gain beyond expected age-related changes, even when thyroid replacement therapy induces a euthyroid state. The aim of this study was to determine whether patients who underwent total thyroidectomy for a wide spectrum of conditions experienced weight gain following surgery. METHODS: We retrospectively studied 107 consecutive total thyroidectomy patients treated between January 2013 and June 2014...
February 14, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29434028/effects-of-thyroid-hormones-on-thermogenesis-and-energy-partitioning
#2
Karl Alexander Iwen, Rebecca Ölkrug, Georg Brabant
Thyroid hormones (TH) are of central importance for thermogenesis, energy homeostasis, and metabolism. Here we will discuss these aspects by focussing on the physiological aspects of TH-dependent regulation in response to cold exposure and fasting which will be compared to alterations in primary hyper- and hypothyroidism. In particular, we will summarise current knowledge on regional thyroid hormone status in the central nervous system (CNS) and in peripheral cells. In contrast to hyper- and hypothyroidism, where parallel changes are observed, local alterations in the CNS differ to peripheral compartments when induced by cold exposure or fasting...
February 6, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29428660/differential-expression-of-the-receptors-for-thyroid-hormone-thyroid-stimulating-hormone-vitamin-d-and-retinoic-acid-and-extracellular-signal-regulated-kinase-in-uterus-of-rats-under-influence-of-sex-steroids
#3
Abu Sadat Md Sayem, Nelli Giribabu, Kamarulzaman Karim, Lay Khiang Si, Sekaran Muniandy, Naguib Salleh
Sex-steroids play important role in modulating uterine functions. We hypothesized that these hormones affect expression of proteins in the uterus related to thyroid hormone action. Therefore, changes in expression levels of receptors for thyroid hormone (TRα-1 and TRβ-1), thyroid stimulating hormone (TSHR), vitamin D (VDR) and retinoid acid (RAR) as well as extracellular signal-regulated kinase (ERK1/2) in uterus were investigated under sex-steroid influence. METHODS: Two rat models were used: (i) ovariectomised, sex-steroid replaced and (ii) intact, at different phases of oestrous cycle...
February 7, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29427748/the-non-thyroidal-illness-syndrome-is-associated-with-postoperative-surgical-site-infections-in-enterocutaneous-fistulae
#4
Huajian Ren, Jianan Ren, Gefei Wang, Zhiwu Hong, Guosheng Gu, Jun Chen, Xiuwen Wu, Qiongyuan Hu, Guanwei Li
BACKGROUND: Non-thyroidal illness syndrome (NTIS) is common in critically ill patients and associated with adverse outcomes. Many enterocutaneous fistula (ECF) patients still suffer NTIS prior to definitive surgery. This study was designed to explore the association between preoperative NTIS and postoperative outcomes in ECF patients. METHODS: A total of 264 ECF patients who underwent definitive surgery from April 2014 to November 2016 were studied. Thyroid hormones were tested for each patient before surgery, and the patients were divided into two groups (NTIS group and euthyroid group) according to the presence of NTIS...
February 7, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29425110/a-japanese-patient-with-congenital-central-hypothyroidism-caused-by-a-novel-igsf1-mutation
#5
Takeshi Yamaguchi, Tomoyuki Hothubo, Shuntaro Morikawa, Akie Nakamura, Toshihiko Mori, Toshihiro Tajima
BACKGROUND: IGSF1 abnormality causes diverse symptoms, including congenital central hypothyroidism (CCH), prolactin hyposecretion, testicular enlargement and delayed puberty. CASE PRESENTATION: Here, we report a case of a male patient who visited our hospital with a chief complaint of abdominal pain and short stature, in whom we identified a novel IGSF1 mutation. He was closely examined because of chronic constipation since infancy, persistent abdominal pain at 14 years of age and marked short stature (-4...
February 9, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29416857/glp1-and-gip-are-involved-in-the-action-of-synbiotics-in-broiler-chickens
#6
Pawel Antoni Kolodziejski, Maciej Sassek, Daniela Chalupka, Natalia Leciejewska, Leszek Nogowski, Pawel Mackowiak, Damian Jozefiak, Katarzyna Stadnicka, Maria Siwek, Marek Bednarczyk, Tomasz Szwaczkowski, Ewa Pruszynska-Oszmalek
Background: In order to discover new strategies to replace antibiotics in the post-antibiotic era in meat-type chicken production, two new synbiotics were tested: (Lactobacillus salivarius IBB3154 plus galactooligosaccharide (Syn1) and Lactobacillus plantarum IBB3036 plus raffinose family oligosaccharides (Syn2). Methods: The synbiotics were administered via syringe, using a special automatic system, into the egg air chamber of Cobb 500 broiler chicks on the 12th day of egg incubation (2 mg of prebiotics + 105 cfu bacteria per egg)...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29390279/ectopic-thyrotropin-secreting-pituitary-adenoma-concomitant-with-papillary-thyroid-carcinoma-case-report
#7
Jing Yang, Shu Liu, Zhe Yang, Yin Bing Shi
RATIONALE: Ectopic thyrotropin (TSH)-secreting pituitary adenomas are exceedingly rare. To date, there are only 6 cases reported. Here, we describe an even rarer ectopic TSH-secreting pituitary adenoma (TSH-oma) concomitant with papillary thyroid carcinoma. PATIENT CONCERNS: A 27-year-old female was admitted to the hospital in 2002 for neck enlargement and palpitation. Thyroid function test showed increased thyroid hormones and unrepressed TSH. Thyroid ultrasound examination displayed diffuse goiter...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29375671/management-of-hypothyroidism-with-combination-thyroxine-t4-and-triiodothyronine-t3-hormone-replacement-in-clinical-practice-a-review-of-suggested-guidance
#8
REVIEW
Colin Dayan, Vijay Panicker
Background: Whilst trials of combination levothyroxine/liothyronine therapy versus levothyroxine monotherapy for thyroid hormone replacement have not shown any superiority, there remains a small subset of patients who do not feel well on monotherapy. Whilst current guidelines do not suggest routine use of combination therapy they do acknowledge a trial in such patients may be appropriate. It appears that use of combination therapy and dessicated thyroid extract is not uncommon but often being used by non-specialists and not adequately monitored...
2018: Thyroid Research
https://www.readbyqxmd.com/read/29368538/annals-express-the-bone-remodelling-cycle
#9
Julia S Kenkre, John H Bassett
The bone remodelling cycle replaces old and damaged bone and is a highly regulated, lifelong process essential for preserving bone integrity and maintaining mineral homeostasis. During the bone remodelling cycle osteoclastic resorption is tightly coupled to osteoblastic bone formation. The remodelling cycle occurs within the Basic Multicellular Unit and comprises five co-ordinated steps; activation, resorption, reversal, formation and termination. These steps occur simultaneously but asynchronously at multiple different locations within the skeleton...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29367365/case-of-acute-mixed-liver-injury-due-to-hypothyroidism
#10
Nikki Duong, Alice Lee, James Lewis
The effects of hypothyroidism on the liver are not well understood. A 77-year-old woman with Hashimoto's thyroiditis had stopped taking levothyroxine on her own for 6 months. Her thyroid stimulating hormone (TSH) level was consistent with severe hypothyroidism. She resumed thyroid replacement therapy. The following month, her liver function tests were significantly elevated. Seven weeks after resumption of therapy, her TSH and liver tests had returned to normal. We attribute the mixed hepatocellular injury to hypothyroidism that resolved on correction of the hypothyroid state...
January 23, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29326865/rectal-atresia-and-congenital-hypothyroidism-an-association-or-coincidence
#11
Feride Mehmetoğlu
Rectal atresia is a rare anorectal malformation, and its association with other anomalies is even more rare. This study presents a unique case of co-twin in which the surviving newborn male underwent surgery due to rectal atresia. Newborn screening tests identified congenital hypothyroidism. The surgical treatment consisted of three stages and thyroid hormones were replaced.
January 2018: European Journal of Pediatric Surgery Reports
https://www.readbyqxmd.com/read/29319127/sexual-function-and-depressive-symptoms-in-young-men-with-hypothyroidism-receiving-levothyroxine-liothyronine-combination-therapy
#12
Robert Krysiak, Bogdan Marek, Bogusław Okopień
INTRODUCTION: Both overt and subclinical hypothyroidism are often accompanied by sexual dysfunction. Despite improving male sexual functioning, levothyroxine treatment does not always restore all its aspects. The aim of this study was to compare male sexual functioning and depressive symptoms between men with hypothyroidism receiving levothyroxine/liothyronine combination therapy and men receiving levothyroxine alone. MATERIAL AND METHODS: The study population consisted of 21 young levothyroxine-treated men with clinical symptoms of hypothyroidism in whom serum thyrotropin and thyroid hormone levels were within the normal limits...
January 10, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29305431/case-of-nasogastric-tube-dysfunction
#13
Florian Rainer, Guenther Prenner, Lukas Peter Binder, Peter Fickert, Johannes Plank
CLINICAL PRESENTATION: An elderly female patient was admitted to intensive care for prolonged vasopressor therapy and mechanical ventilation after cardiac arrest and acute percutaneous coronary intervention. Antiplatelet, thyroid hormone replacement and statin therapies were administered through a 14-French nasogastric tube (Nestlé Health Science) and enteral feeding was initiated. Correct position of the nasogastric tube was confirmed radiologically. On the seventh day in the intensive care, our patient was seen to regurgitate soft crumbs into her mouth...
January 5, 2018: Gut
https://www.readbyqxmd.com/read/29302874/anti-m%C3%A3-llerian-hormone-in-pre-menopausal-females-after-ablative-radioiodine-treatment-for-differentiated-thyroid-cancer
#14
Massimo Giusti, Miranda Mittica, Paola Comite, Claudia Campana, Stefano Gay, Michele Mussap
PURPOSE: In recent years, anti-Mullerian hormone (AMH) has been considered a reliable index of ovarian reserve. There are few data on AMH values in thyroid cancer. The aim of this study was to evaluate AMH levels in pre-menopausal women with a history of low-risk thyroid cancer. METHODS: Thirty-four women (aged 40.7 ± 6.7 years) were studied 7.1 ± 0.9 years after surgery and at least one RAI treatment. A group of 23 thyroid cancer women (41.6 ± 7...
January 4, 2018: Endocrine
https://www.readbyqxmd.com/read/29301248/differences-in-the-plasma-proteome-of-patients-with-hypothyroidism-before-and-after-thyroid-hormone-replacement-a-proteomic-analysis
#15
Assim A Alfadda, Hicham Benabdelkamel, Afshan Masood, Anwar A Jammah, Aishah A Ekhzaimy
Thyroid hormone is a potent stimulator of metabolism, playing a critical role in regulating energy expenditure and in key physiological mechanisms, such as growth and development. Although administration of thyroid hormone in the form of levo thyroxine (l-thyroxine) has been used to treat hypothyroidism for many years, the precise molecular basis of its physiological actions remains uncertain. Our objective was to define the changes in circulating protein levels that characterize alterations in thyroid hormone status...
January 1, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29297967/levothyroxine-supplementation-improves-serum-anti-m%C3%A3-llerian-hormone-levels-in-infertile-patients-with-hashimoto-s-thyroiditis
#16
Masako Kuroda, Keiji Kuroda, Tomoya Segawa, Jaeduk Y Noh, Ai Yoshihara, Koichi Ito, Hisao Osada, Satoru Takeda, Shokichi Teramoto
AIM: Thyroid dysfunction and autoimmunity are associated with an adverse effect on fertility. An aberrant high thyroid stimulating hormone level is associated with diminished ovarian reserve in women of reproductive age; however, the utility of levothyroxine (LT4) replacement for infertile patients with subclinical hypothyroidism is still under discussion. The aim of this study was to investigate whether LT4 supplementation for infertile patients with subclinical hypothyroidism improves impaired ovarian function...
January 3, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29285444/optimal-levothyroxine-replacement-adequately-improves-symptoms-of-hypothyroidism-residual-symptoms-need-further-evaluation-for-other-than-hypothyroidism-causation
#17
Rekha Singh, Ashwani Tandon, Sushil Kumar Gupta, K Saroja
Objectives: Many patients with hypothyroidism complain of persistent residual symptoms, despite optimal treatment, although the similar prevalence is seen in patients with documented absence of thyroid disorder in primary health-care setup. We aimed to investigate symptomatic relief in new cases of primary hypothyroidism and compare with controls with other chronic conditions. Methods: This prospective case-control follow-up study enrolled patients from July 2014 to May 2015 in an endocrine outpatient clinic of a tertiary hospital...
November 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29284719/cross-sectional-analyses-of-participation-in-cancer-screening-and-use-of-hormone-replacement-therapy-and-medications-in-meat-eaters-and-vegetarians-the-epic-oxford-study
#18
Tammy Y N Tong, Paul N Appleby, Kathryn E Bradbury, Timothy J Key
OBJECTIVES: To examine differences in health-related behaviours such as screening or testing for cancer, use of hormone replacement therapy (HRT) and use of other medications in different diet groups. DESIGN: We studied 31 260 participants across four diet groups (18 155 meat eaters, 5012 fish eaters, 7179 vegetarians, 914 vegans) in the UK EPIC-Oxford cohort. Information was collected in 5-year (around 2000-2003) or 10-year (around 2007) follow-up questionnaires regarding participation in breast screening, cervical screening, prostate-specific antigen (PSA) testing, use of HRT and use of medications for the past 4 weeks...
December 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/29258382/efficacy-of-a-home-based-exercise-program-after-thyroidectomy-for-thyroid-cancer-patients
#19
Kyunghee Kim, Mee Ock Gu, Jung Hwa Jung, Jong Ryeal Hahm, Soo Kyoung Kim, Jin Hyun Kim, Seung Hoon Woo
BACKGROUND: The objective of this study was to determine the effect of a home-based exercise program on fatigue, anxiety, quality of life (QoL), and immune function of thyroid cancer patients taking thyroid hormone replacement after thyroidectomy. METHOD: This quasi-experimental study with a non-equivalent control group included 43 outpatients taking thyroid hormone replacement after thyroidectomy (22 in the experimental group and 21 in the control group). After education about the home-based exercise program, subjects in the experimental group underwent 12 weeks of aerobic, resistance, and flexibility exercise...
January 18, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29240719/pericardial-effusion-as-a-presenting-symptom-of-hashimoto-thyroiditis-a-case-report
#20
Alberto Leonardi, Laura Penta, Marta Cofini, Lucia Lanciotti, Nicola Principi, Susanna Esposito
Background: Hashimoto thyroiditis (HT) is the most frequent cause of acquired hypothyroidism in paediatrics. HT is usually diagnosed in older children and adolescents, mainly in females and is rare in infants and toddlers with cardiac involvement, including pericardial effusion, that can be found in 10% to 30% of adult HT cases. In this paper, a child with HT and pericardial effusion as the most important sign of HT is described. Case presentation: A four-year-old male child suffering for a few months from recurrent abdominal pain sometimes associated with vomiting underwent an abdominal ultrasound scan outside the hospital...
December 14, 2017: International Journal of Environmental Research and Public Health
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