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Thyroid hormone replacement

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https://www.readbyqxmd.com/read/29218227/lessons-learnt-from-a-case-of-missed-central-hypothyroidism
#1
Tessa Glyn, Beverley Harris, Kate Allen
We present the case of a 57-year-old lady who had a delayed diagnosis of central hypothyroidism on a background of Grave's thyrotoxicosis and a partial thyroidectomy. During the twenty years following her partial thyroidectomy, the patient developed a constellation of symptoms and new diagnoses, which were investigated by numerous specialists from various fields, namely rheumatology, renal and respiratory. She developed significantly impaired renal function and raised creatine kinase (CK). She was also referred to a tertiary neurology service for investigation of myositis, which resulted in inconclusive muscle biopsies...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29214049/latent-autoimmune-diabetes-of-adulthood-case-report
#2
Cristen P Page, Brian Fitzgerald, Emily M Hawes
Background: Primary care clinicians will see a higher incidence of type 2 diabetes in adult patients, and the diagnosis and management of an initial presentation of type 1 diabetes can pose challenges to clinicians who see it less frequently. Symptoms of hyperglycemia and risk of ketoacidosis may be missed. Further, endocrine autoimmune disease can run together in patients and families. Case presentation: A 49-year-old Caucasian female with history of pituitary adenoma and Graves' disease with history of thyroid ablation presented in the outpatient setting due to hand tingling of her right middle finger that was worse in the mornings and improved throughout the day...
2017: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29204393/lymphocutaneous-sporotrichosis-treated-with-potassium-iodide-with-development-of-subclinical-hypothyroidism-wolff-chaikoff-effect
#3
Pooja Arora, M Raihan, Asha Kubba, Ram K Gautam
Sporotrichosis is a subcutaneous mycotic infection caused by Sporothrix schenckii that is acquired by traumatic implantation. The diagnosis is established by demonstration of fungal elements on histopathology and culture. Potassium iodide, azole antifungals, and terbinafine are the treatment options available. In this article, we report a 60-year-old female with lymphocutaneous sporotrichosis that responded well to potassium iodide. However, subclinical hypothyroidism (Wolff-Chaikoff effect) was encountered as a side effect of therapy which was managed with thyroxine replacement...
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29197845/neck-mass-an-obstructive-cause-of-respiratory-distress-with-medical-management
#4
Vijay Singh, Aakash Pandita, Girish Gupta, Amit Shukla
Congenital goitre is a known cause of hypothyroidism in newborn. Congenital goitre can be due to defective synthesis of thyroxine or administration of antithyroid drugs to the mother during pregnancy. In this case report, we report an instance of a preterm male infant with antenatally detected goitre presenting as a neck mass with congenital hypothyroidism. Hormonal replacement therapy was started immediately after birth which lead to resolution of the mass and normalisation of thyroid function.
December 2, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29181135/graves-disease-thyrotoxicosis-and-propylthiouracil-related-agranulocytosis-successfully-treated-with-therapeutic-plasma-exchange-and-g-csf-followed-by-total-thyroidectomy
#5
Anna Candoni, Federico De Marchi, Fabio Vescini, Sara Mauro, Cristina Rinaldi, Marco Piemonte, Nicholas Rabassi, Maria Vittoria Dubbini, Renato Fanin
Antithyroid drugs can be a rare cause of agranulocytosis (0.5% of treated patients). Suspension of these drugs is mandatory in these patients and may result in worsening hyperthyroidism. We report the case of a 27-year-old woman who is 3 months post-partum, breastfeeding, and suffering with Graves' disease hyperthyroidism treated first with methimazole and then with propylthiouracil due to a methimazole allergy. She was admitted for urosepsis and agranulocytosis. The patient was diagnosed with propylthiouracil related agranulocytosis, diffuse toxic goiter and thyro-gastric syndrome...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29170719/subclinical-hypothyroidism-and-its-association-with-increased-cardiovascular-mortality
#6
REVIEW
Alvaro Altamirano Ufion, Beenish Zulfiqar, Abdalla Hassan, Roshanak Habibi, Prajwal Boddu
Thyroid hormones play an important role in regulating different metabolism functions and multiple organs' performance. Changes in the thyroid hormone axis can lead to profound effects on the stability of vital organs and systems, especially the cardiovascular system. Hypothyroidism is classified according to the clinical presentation as overt and subclinical. There is some evidence supporting the benefits of thyroxine hormone replacement for subclinical hypothyroidism on cardiovascular mortality outcomes. However, the clinical relevance of measuring and treating high thyroid-stimulating hormone (TSH) levels in newly diagnosed heart failure patients with preserved ejection fraction requires further study...
2017: Cardiology Research and Practice
https://www.readbyqxmd.com/read/29141371/-effect-of-recombinant-human-growth-hormone-therapy-on-metabolic-parameters-in-patients-with-craniopharyngioma
#7
J F Mao, X Wang, S Y Xiong, J J Zheng, B Q Yu, M Nie, X Y Wu, S T Qi
Objective: To investigate the effects of recombinant human growth hormone (rhGH) on metabolic parameters in patients with craniopharyngioma surgeries. Methods: Totallys 30 patients with craniopharyngioma were included in this retrospective study. They were divided into growth hormone (GH) group and control group according to whether they received rhGH therapy or not. The following parameters, including body mass index (BMI), weight, waist circumstance, transaminase, fasting blood glucose, lipid profile and high-sensitivity C-reactive protein (hsCRP) were compared after rhGH therapy for 4-6 months...
November 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29123944/hypothyroidism-induced-reversible-encephalopathy-as-a-cause-of-aggravation-of-parkinsonism-and-myoclonus-in-parkinson-s-disease
#8
Gwanhee Ehm, Han-Joon Kim, Beomseok Jeon
Background: Myoclonus and encephalopathy are unusual in patients with Parkinson's disease (PD). Case report: We describe the case of a 59-year-old male with PD who developed myoclonus and encephalopathy. Underlying hypothyroidism was revealed after admission and treated with levothyroxine. Myoclonus and encephalopathy were completely resolved following thyroid hormone replacement. Discussion: Hypothyroidism can cause reversible myoclonus and encephalopathy along with unusual aggravation of parkinsonism symptoms in patients with PD...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/29120652/-hypothyroidism-in-patients-with-heart-disease
#9
Jan Jiskra
Hypothyroidism is frequently found in patients with heart disease. It is a risk factor for atherosclerosis and ischemic heart disease and has a direct negative effect on both the left and right ventricular functions (hypothyroidism-induced cardiomyopathy). The confirmed manifest hypothyroidism is always a reason for replacement therapy with levothyroxine; regarding patients with heart disease, we always begin treatment with a small dose and increase it gradually. The treatment of subclinical hypothyroidism in patients with heart disease is disputable and its benefits probably depend on age...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29105624/effects-of-thyroid-hormone-replacement-therapy-on-thyroid-hormone-levels-and-electrocardiogram-changes-in-geriatric-patients-with-hypothyroidism
#10
Xianghong Zhai
This paper aims to analyze the effects of thyroid hormone replacement therapy on thyroid hormone levels and electrocardiogram changes in elderly patients with hypothyroidism. 48 elderly patients with hypothyroidism admitted to our hospital from January 2014 to December 2014 were selected as subjects. All the patients were treated with thyroid hormone replacement therapy. The changes of thyroid hormone levels and ECG parameters were compared before and after treatment. After treatment, serum thyroid stimulating hormone (TSH) was significantly lower than that before treatment, and the free triiodothyronine (FT3) and free thyroxine (FT4) were significantly higher than those before treatment (t=15...
September 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29095280/primary-hypothyroidism-and-isolated-acth-deficiency-induced-by-nivolumab-therapy-case-report-and-review
#11
REVIEW
Mei Fang Zeng, Li Chen, Hong Ying Ye, Wei Gong, Li Nuo Zhou, Yi Ming Li, Xiao Long Zhao
RATIONALE: Nivolumab is a monoclonal IgG antibody blocking programmed death receptor-1 (PD1), leading to restoration of the natural T-cell-mediated immune response against the cancer cells. However, it also causes plenty of autoimmune-related adverse events, which often involves endocrine system. PATIENT CONCERNS: A 54-year-old male with renal clear cell carcinoma was treated with nivolumab intravenously. Routine monitoring showed elevated thyroid-stimulating hormone and low free thyroxine after the 6th administration of nivolumab...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29076198/heterotopic-thyroid-autotransplantation-a-preliminary-clinical-study
#12
Mahmoud Sakr, Yasser El-Kerm, Waleed Abo-Elwafa, Ahmed Mahmoud, Ibrahim Fathi
BACKGROUND: Thyroid autotransplantation offers an attractive alternative to subtotal thyroidectomy and replacement therapy. However, it has not been sufficiently clinically investigated. METHODS: Total thyroidectomy was performed for 20 patients with benign thyroid disorders, and at least 10 g of thyroid tissue were implanted intramuscularly. Graft monitoring was achieved through 99m Tc scan at 2 months, free triiodothyronine (FT3), FT4, and thyroid-stimulating hormone (TSH) measurements at 1, 2, 4, 6, 8, 10, and 12 months postoperatively, and clinical examination...
October 27, 2017: Head & Neck
https://www.readbyqxmd.com/read/29069456/thyroid-state-regulates-gene-expression-in-human-whole-blood
#13
Elske T Massolt, Marcel E Meima, Sigrid M A Swagemakers, Selmar Leeuwenburgh, Mirjam C G M van den Hout-van Vroonhoven, Giulia Brigante, Boen L R Kam, Peter J van der Spek, Wilfred F J van IJcken, Theo J Visser, Robin P Peeters, W Edward Visser
Context: Despite the well-recognized clinical features due to insufficient or excessive thyroid hormone (TH) levels in humans, it is largely unknown which genes are regulated by TH in human tissues. Objective: To study the effect of TH on human gene expression profiles in whole blood, mainly consisting of TRα-expressing cells. Methods: We performed next-generation RNA sequencing on whole blood samples from 8 athyroid patients (4 females) on and after 4 weeks off levothyroxine replacement...
October 23, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29062486/cardiac-tamponade-in-a-patient-with-autoimmune-polyglandular-syndrome-type-2
#14
Andromachi Vryonidou, Stavroula A Paschou, Fotini Dimitropoulou, Panagiotis Anagnostis, Vasiliki Tzavara, Apostolos Katsivas
We describe a case of a 40-year-old woman who was admitted to the intensive care unit with a rapid onset of dyspnea and orthopnea. She presented progressive weakness, weight loss and secondary amenorrhea during last year, while intermittent fever was present for the last two months. Initial biochemical evaluation showed anemia, hyponatremia and increased C-reactive protein levels. Clinical and echocardiographic evaluation revealed cardiac tamponade, which was treated with pericardiocentesis. Pleural fluid samples were negative for malignancy, tuberculosis or bacterial infection...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29048919/does-treatment-of-either-hypothyroidy-or-hyperthyroidy-affect-diurnal-blood-pressure
#15
Mutlu Demirel, Gül Gürsoy, Mehmet Yıldız
OBJECTIVE: Thyroid hormone has well recognized effects on the cardiovascular system. The purpose of this study was to define the influence of treatment of either hypothyroidism and hyperthyroidism on the values and circadial variations of arterial blood pressure measured by ambulatory blood pressure monitoring. MATERIAL AND METHODS: The study was carried out on 30 hypothyroidic and 30 hyperthyroidic patients without hypertension and 46 healthy participants. First, all the parameters of the groups, then blood pressure values obtained by ambulatory blood pressure monitoring before and after treatment (thyroid hormone replacement with levothyroxine and antithyroid treatment either with propylthyrouracil or metimazole) were compared...
September 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29040069/effects-of-1-year-growth-hormone-replacement-therapy-on-thyroid-volume-and-function-of-the-children-and-adolescents-with-idiopathic-growth-hormone-deficiency
#16
Meliksah Keskin, Elvan Bayramoglu, Zehra Aycan
BACKGROUND: There are different opinions about the effects of growth hormone replacement therapy (GHRT) on thyroid function and volume. This study aimed to assess the effects of GHRT on thyroid volume and function in the children and adolescents with growth hormone (GH) deficiency. METHODS: A total of 29 patients diagnosed with GH deficiency were enrolled in the study. The control group consisted of 29 cases matched for age, gender and pubertal period with the patients...
October 26, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28976876/parathyroidectomy-in-hyperparathyroidism-associated-calciphylaxis-in-end-stage-renal-disease-should-be-prompt-and-radical-a-case-report-with-two-original-therapeutic-modifications-and-successful-outcome
#17
Sylvie Dusilová Sulková, Jiří Horáček, Eva Vykoukalová, Roman Šafránek, Alena Malá, Vladimír Palička
We present a case of severe calciphylaxis in both thighs and calves in a patient with end-stage renal disease and advanced secondary hyperparathyroidism with successful outcome after modified therapeutic approach. The cause of calciphylaxis is multifactorial. In our case, not only severe hyperparathyroidism and mediocalcinosis, but also medication (warfarin, calcium and active vitamin D) was involved. Because the initial conservative therapy was not successful, we indicated parathyroidectomy. However, we were not able to localize parathyroid glands and we contraindicated bilateral neck exploration due to the patient's critical status...
2017: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/28973666/exposure-of-pregnant-mice-to-triclosan-causes-insulin-resistance-via-thyroxine-reduction
#18
Xu Hua, Xin-Yuan Cao, Xiao-Li Wang, Peng Sun, Ling Chen
Exposure to triclosan (TCS), an antibacterial agent, during pregnancy is associated with hypothyroxinemia and decreases in placental glucose transporter expression and activity. The objective of this study was to investigate the influence of TCS on glucose homeostasis and insulin sensitivity in gestational mice (G-mice) and nongestational female mice (Ng-mice) as a control. Herein, we show that the exposure of G-mice to TCS (8 mg/kg) from gestational day (GD) 5 to GD17 significantly increased their levels of fasting plasma glucose and serum insulin, and insulin content in pancreatic β-cells with reduced homeostasis model assessment (HOMA)-β index and increased HOMA-IR index...
November 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28964732/effects-of-thyroid-hormone-manipulation-on-pre-nuptial-molt-luteinizing-hormone-and-testicular-growth-in-male-white-crowned-sparrows-zonotrichia-leuchophrys-gambelii
#19
Jonathan H Pérez, Simone L Meddle, John C Wingfield, Marilyn Ramenofsky
Most seasonal species rely on the annual change in day length as the primary cue to appropriately time major spring events such as pre-nuptial molt and breeding. Thyroid hormones are thought to be involved in the regulation of both of these spring life history stages. Here we investigated the effects of chemical inhibition of thyroid hormone production using methimazole, subsequently coupled with either triiodothyronine (T3) or thyroxine (T4) replacement, on the photostimulation of pre-nuptial molt and breeding in Gambel's white-crowned sparrows (Zonotrichia leuchophrys gambelii)...
January 1, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28964662/replacement-therapy-with-levothyroxine-modulates-platelet-activation-in-recent-onset-post-thyroidectomy-subclinical-hypothyroidism
#20
RANDOMIZED CONTROLLED TRIAL
G Desideri, R Bocale, A D'Amore, S Necozione, M Boscherini, G Carnassale, A Barini, A Barini, R Bellantone, C P Lombardi
BACKGROUND AND AIM: Subclinical hypothyroidism has been linked to increased risk of atherosclerotic disease. Soluble CD40 ligand (sCD40L), mainly derived from activated platelets, and the lipid peroxidation product 8-iso-prostaglandin F2α (8-iso-PGF2α) are known to play a relevant pathophysiological role in atherogenesis. In this study, we analyzed the relationship between thyroid hormones and circulating levels of sCD40L and 8-iso-PGF2α in patient with recent-onset post-thyroidectomy subclinical hypothyroidism under replacement therapy...
October 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
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