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Thyroid hormone replacement

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https://www.readbyqxmd.com/read/29658834/alterations-in-thyroid-hormone-levels-following-growth-hormone-replacement-exert-complex-biological-effects
#1
Nigel Glynn, Helena Kenny, Tarik Salim, David J Halsall, Diarmuid Smith, Tommy Kyaw Tun, John H McDermott, William Tormey, Christopher J Thompson, Brendan McAdam, Donal O' Gorman, Amar Agha
OBJECTIVE: Alterations in the thyroid axis are frequently observed following growth hormone (GH) replacement, but uncertainty exists regarding their clinical significance. We aimed to compare fluctuations in circulating thyroid hormone levels, induced by GH, to changes in sensitive biological markers of thyroid hormone action. METHODS: This was a prospective observational clinical study. Twenty hypopituitary men were studied before and after GH replacement. Serum thyroid-stimulating hormone (TSH), thyroid hormones, and insulin-like growth factor 1 were measured...
April 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29655787/secretory-expression-and-scale-up-production-of-recombinant-human-thyroid-peroxidase-via-baculovirus-insect-cell-system-in-a-wave-type-bioreactor
#2
Ying Lou, Guorong Ji, Qin Liu, Pengbo Wang, Ruilin Zhang, Yuanxing Zhang, Xiaohong Liu
The human thyroid peroxidase (hTPO) is an essential enzyme for thyroid hormone biosynthesis and is expressed in thyroid cells. It is an autoantigen against which antibodies are found in the sera of patients with a number of autoimmune thyroid disorders. Overexpression of hTPO has been achieved using the baculovirus expression vector system (BEVS). However, it is produced largely in an aggregated form in the cell lysate fraction, which increases the complexity of protein extraction. In this study, to achieve improved secretory expression of hTPO via BEVS, a truncated recombinant hTPO protein (hTPOt) was engineered by replacing its original signal peptide (SP) in the N-terminal with five heterologous SPs...
April 12, 2018: Protein Expression and Purification
https://www.readbyqxmd.com/read/29652599/risk-factors-for-new-hypothyroidism-during-tyrosine-kinase-inhibitor-therapy-in-advanced-nonthyroidal-cancer-patients
#3
Melissa G Lechner, Chirag M Vyas, Ole-Petter R Hamnvik, Erik K Alexander, P Reed Larsen, Toni K Choueiri, Trevor E Angell
BACKGROUND: Thyroid dysfunction during tyrosine kinase inhibitor (TKI) cancer treatment is common, but predisposing risk factors have not been determined. Recommendations for monitoring patients treated with one or multiple TKI and in conjunction with other relevant cancer therapies could be improved. The study objective was to assess the risk factors for new thyroid dysfunction in TKI-treated previously euthyroid cancer patients. METHODS: A retrospective cohort study of patients with advanced nonthyroidal cancer treated with TKI from 2000 to 2017, having available thyroid function tests showing initial euthyroid status, excluding patients with preexisting thyroid disease or lack of follow-up thyroid function tests...
April 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29652597/hypothyroidism-during-tyrosine-kinase-inhibitor-therapy-is-associated-with-longer-survival-in-patients-with-advanced-nonthyroidal-cancers
#4
Melissa G Lechner, Chirag M Vyas, Ole-Petter R Hamnvik, Erik K Alexander, P Reed Larsen, Toni K Choueiri, Trevor E Angell
BACKGROUND: Tyrosine kinase inhibitor (TKI)-induced thyroid dysfunction is recognized as a common adverse effect of treatment, but the importance of incident hypothyroidism during TKI therapy remains unclear. This study analyzed the prognostic significance of hypothyroidism during TKI therapy in cancer patients. METHODS: This was a retrospective cohort study of adult patients with advanced nonthyroidal cancer treated with TKI and available thyroid function testing at three affiliated academic hospitals from 2000 to 2017...
April 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29649216/serum-microrna-profiles-in-athyroid-patients-on-and-off-levothyroxine-therapy
#5
Elske T Massolt, Layal Chaker, Theo J Visser, Ad J M Gillis, Lambert C J Dorssers, Carolien M Beukhof, Boen L R Kam, Gaston J Franssen, Giulia Brigante, Tessa M van Ginhoven, W Edward Visser, Leendert H J Looijenga, Robin P Peeters
BACKGROUND: Levothyroxine replacement treatment in hypothyroidism is unable to restore physiological thyroxine and triiodothyronine concentrations in serum and tissues completely. Normal serum thyroid stimulating hormone (TSH) concentrations reflect only pituitary euthyroidism and, therefore, novel biomarkers representing tissue-specific thyroid state are needed. MicroRNAs (miRNAs), small non-coding regulatory RNAs, exhibit tissue-specific expression patterns and can be detectable in serum...
2018: PloS One
https://www.readbyqxmd.com/read/29642533/rhabdomyolysis-in-a-young-girl-with-van-wyk-grumbach-syndrome-due-to-severe-hashimoto-thyroiditis
#6
Alberto Leonardi, Laura Penta, Marta Cofini, Lucia Lanciotti, Nicola Principi, Susanna Esposito
Background: Autoimmune hypothyroidism (Hashimoto thyroiditis; HT) is the most common postnatal thyroid disease. Clinical manifestations of HT vary according to disease severity. Due to the pleiotropic effects of thyroid hormone, less common signs and symptoms of HT can occur, leading to a delay in diagnosis. Case presentation: A 9-year-old girl of Indian origin was admitted for a one-week history of widespread myalgia, fatigue, muscle weakness, difficulty walking, and a significant increase in weight (approximately 2 kg) without any changes in daily habits...
April 9, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29625991/t-3-induces-both-markers-of-maturation-and-aging-in-pancreatic-%C3%AE-cells
#7
Cristina Aguayo-Mazzucato, Terence B Lee, Michelle Matzko, Amanda DiIenno, Habib Rezanejad, Preeti Ramadoss, Thomas Scanlan, Ann Marie Zavacki, P Reed Larsen, Anthony Hollenberg, Clark Colton, Arun Sharma, Susan Bonner-Weir
Previously we showed thyroid hormone (T3 ) enhanced β-cell functional maturation through induction of Mafa High levels of T3 have been linked to decreased lifespan in mammals, and low levels to lengthened lifespan, suggesting a relationship between thyroid hormone and aging. Here we show T3 increased p16 Ink4a (a β-cell senescence marker and effector) mRNA in rodent and human β-cells. The kinetics of Mafa and p16 Ink4a induction suggested both genes as targets of thyroid hormone via TH receptor (THR) binding to specific response elements (TRE)...
April 6, 2018: Diabetes
https://www.readbyqxmd.com/read/29619769/multiple-hormonal-and-metabolic-deficiency-syndrome-in-chronic-heart-failure-rationale-design-and-demographic-characteristics-of-the-t-o-s-ca-registry
#8
E Bossone, M Arcopinto, M Iacoviello, V Triggiani, F Cacciatore, C Maiello, G Limongelli, D Masarone, F Perticone, A Sciacqua, P Perrone-Filardi, A Mancini, M Volterrani, O Vriz, R Castello, A Passantino, M Campo, P A Modesti, A De Giorgi, I Monte, A Puzzo, A Ballotta, L Caliendo, R D'Assante, A M Marra, A Salzano, T Suzuki, A Cittadini
Recent evidence supports the concept that progression of chronic heart failure (CHF) depends upon an imbalance of catabolic forces over the anabolic drive. In this regard, multiple hormonal deficiency syndrome (MHDS) significantly has impacts upon CHF progression, and is associated with a worse clinical status and increased mortality. The T.O.S.CA. (Trattamento Ormonale nello Scompenso CArdiaco; Hormone Therapy in Heart Failure) Registry (clinicaltrial.gov = NCT02335801) tests the hypothesis that anabolic deficiencies reduce survival in a large population of mild-to-moderate CHF patients...
April 4, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29600292/patients-with-antithyroid-antibodies-are-prone-to-develop-destructive-thyroiditis-by-nivolumab-a-prospective-study
#9
Tomoko Kobayashi, Shintaro Iwama, Yoshinori Yasuda, Norio Okada, Taku Tsunekawa, Takeshi Onoue, Hiroshi Takagi, Daisuke Hagiwara, Yoshihiro Ito, Yoshiaki Morishita, Motomitsu Goto, Hidetaka Suga, Ryoichi Banno, Kenji Yokota, Tetsunari Hase, Masahiro Morise, Naozumi Hashimoto, Masahiko Ando, Hitoshi Kiyoi, Momokazu Gotoh, Yuichi Ando, Masashi Akiyama, Yoshinori Hasegawa, Hiroshi Arima
Context: Immune checkpoint inhibitors, including anti-programmed cell death-1 (PD-1) antibodies, have become promising treatments for a variety of advanced malignancies. However, these medicines can cause immune-related adverse events (irAEs), including endocrinopathies. Objective: This study examined the incidence of endocrine irAEs induced by nivolumab. Patients and Main Outcome Measured: Sixty-six patients treated with nivolumab at Nagoya University Hospital were prospectively evaluated for pituitary hormones, thyroid function, antithyroid antibodies (Abs), and glucose levels every 6 weeks after the initiation of nivolumab for 24 weeks...
March 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29581918/steroids-and-thyrotoxicosis-precipitate-periodic-paralysis
#10
Rizwan Ahamed, Sarah McCalley, Anupam A Sule
Thyrotoxic Periodic Paralysis (TPP) belongs to a group of muscle diseases called channelopathies, which present with painless generalized muscle weakness without exertion. TPP can be precipitated by a large carbohydrate meal, stress, strenuous exercise, alcohol, a high-salt diet, menstruation, and cold temperatures. Rarely, steroids such as dexamethasone can also precipitate a TPP attack. A 29-year-old Hispanic male, with a history of hyperthyroidism, presented to the emergency department with progressive weakness, predominantly in the lower extremities since morning...
January 23, 2018: Curēus
https://www.readbyqxmd.com/read/29572710/liquid-l-thyroxine-versus-tablet-l-thyroxine-in-patients-on-l-thyroxine-replacement-or-suppressive-therapy-a-meta-analysis
#11
Irakoze Laurent, Siying Tang, Manirakiza Astère, Kan Ran Wang, Shuhua Deng, Ling Xiao, Qi Fu Li
PURPOSE: To compare the effectiveness of liquid L-T4 (L-thyroxine) and tablet L-T4 in patients on L-T4 replacement or suppressive therapy. METHODS: The Cochrane Library, PubMed, Embase, and Web of Science databases were searched to identify relevant articles. All prospective or randomized controlled studies (RCTs) comparing liquid L-T4 and tablet L-T4 in patients on L-T4 replacement or suppressive therapy were included in the analysis. RESULTS: Overall, the initial search of the four databases identified 1278 published studies; of these, eight studies were ultimately included in the meta-analysis...
March 23, 2018: Endocrine
https://www.readbyqxmd.com/read/29567842/prevalence-of-potentially-inappropriate-prescribing-in-a-subpopulation-of-older-european-clinical-trial-participants-a-cross-sectional-study
#12
David O Riordan, Carole Elodie Aubert, Kieran A Walsh, Anette Van Dorland, Nicolas Rodondi, Robert S Du Puy, Rosalinde K E Poortvliet, Jacobijn Gussekloo, Carol Sinnott, Stephen Byrne, Rose Galvin, J Wouter Jukema, Simon P Mooijaart, Christine Baumgartner, Vera McCarthy, Elaine K Walsh, Tinh-Hai Collet, Olaf M Dekkers, Manuel R Blum, Patricia M Kearney
OBJECTIVES: To estimate and compare the prevalence and type of potentially inappropriate prescribing (PIP) and potential prescribing omissions (PPOs) among community-dwelling older adults (≥65 years) enrolled to a clinical trial in three European countries. DESIGN: A secondary analysis of the Thyroid Hormone Replacement for Subclinical Hypothyroidism Trial dataset. PARTICIPANTS: A subset of 48/80 PIP and 22/34 PPOs indicators from the Screening Tool of Older Persons Prescriptions/Screening Tool to Alert doctors to Right Treatment (STOPP/START) V2 criteria were applied to prescribed medication data for 532/737 trial participants in Ireland, Switzerland and the Netherlands...
March 22, 2018: BMJ Open
https://www.readbyqxmd.com/read/29562858/nivolumab-induced-synchronous-occurrence-of-myositis-and-hypothyroidism-in-a-patient-with-squamous-cell-lung-cancer
#13
Sonja Badovinac, Marta Korsic, Kamelija Zarkovic, Davorka Mursic, Mihovil Roglic, Marko Jakopovic, Miroslav Samarzija
AIM: Alongside the proven efficacy, immunotherapy in treatment of malignant diseases can cause immune-related adverse events different from commonly known chemotherapy-related toxicities. CASE PRESENTATION: During nivolumab treatment of metastatic squamous cell lung cancer, the patient developed a symptomatic inflammatory myositis confirmed with muscle biopsy and primary hypothyroidism. After initiation of corticosteroids and thyroid hormone replacement, the clinical and laboratory improvement occurred...
March 1, 2018: Immunotherapy
https://www.readbyqxmd.com/read/29560762/initiation-timing-effect-of-levothyroxine-treatment-on-subclinical-hypothyroidism-in-pregnancy
#14
Lijie Zhao, Guojing Jiang, Xingfang Tian, Xiaoqin Zhang, Ting Zhu, Beibei Chen, Yongxiang Wang, Qingliang Ma
The aim of this study is to estimate the timing impact on levothyroxine replacement among pregnant women with subclinical hypothyroidism (SCH). Ninety-eight pregnant women diagnosed as SCH in the first trimester were randomly divided into three groups: Group A, instantly initiated levothyroxine after diagnosis; Group B, administrated treatment in the second trimester, and Group C, received no prescription. Incidence of pregnancy complications and pregnancy outcomes were compared among three groups and subgroup analysis were performed stratified with TPO status in Group B...
March 21, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29547051/thyroid-hormone-replacement-reduces-the-risk-of-cardiovascular-diseases-in-diabetic-nephropathy-patients-with-subclinical-hypothyroidism
#15
Changhwan Seo, Seonghun Kim, Misol Lee, Min-Uk Cha, Hyoungnae Kim, Seohyun Park, Hae-Ryong Yun, Jong Hyun Jhee, Youn Kyung Kee, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang, Jung Tak Park
OBJECTIVE: Patients with diabetic nephropathy (DMN) have an increased risk of cardiovascular disease (CVD). However, strategies to reduce this risk are limited. Thyroid hormone replacement therapy (THRT) in patients with hypothyroidism has been shown to reduce several surrogate markers of CVD. Therefore, we performed a study to determine if THRT would reduce CVD risk in patients with subclinical hypothyroidism (SCH) and DMN. METHODS: This was a retrospective, nonrandomized study of patients with type 2 diabetes, DMN, and SCH...
March 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29541701/does-tsh-reliably-detect-hypothyroid-patients
#16
C Ling, Q Sun, J Khang, M Felipa Lastarria, J Strong, B Stolze, X Yu, T P Parikh, M A Waldman, K Welsh, J Jonklaas, L Masika, S J Soldin
Objectives: To evaluate the reliability of normal Thyroid Stimulating Hormone (TSH) as a thyroid function test and assess the effect of Adrenocorticotropic Hormone (ACTH) on serum TSH concentration. Design and Methods: Patients presenting to the National Institutes of Health Department of Endocrinology outpatient clinic with symptoms consistent with hypothyroidism were identified. Thyroid hormone concentrations were measured by liquid chromatography/tandem mass spectrometry and immunoassay...
2018: Annals of Thyroid Research
https://www.readbyqxmd.com/read/29537398/thyroid-hormone-replacement-a-counterblast-to-guidelines
#17
A D Toft
No abstract text is available yet for this article.
December 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29529842/risk-factors-for-hypothyroidism-in-euthyroid-thyroid-nodule-patients-with-lymphocytic-thyroiditis-on-fine-needle-aspiration-cytology
#18
Jeong-Min Lee, Jeonghoon Ha, Kwanhoon Jo, Yejee Lim, Min-Hee Kim, Chan-Kwan Jung, So-Lyung Jung, Moo-Il Kang, Bong-Yun Cha, Dong-Jun Lim
Background/Aims: Lymphocytic thyroiditis as cytology diagnosis from fine needle aspiration (FNA) is frequently detected in patients with thyroid nodules. However, the clinical outcome for upcoming hypothyroid events has been rarely clarified in euthyroid patients. Methods: We retrospectively reviewed the data of patient who had lymphocytic thyroitidis on FNA cytology of thyroid nodule from January 2005 to December 2010 at a tertiary referral hospital. In total, 109 patients with follow-up thyroid function tests (TFT) were enrolled...
March 13, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29518754/endocrine-sequelae-of-immune-checkpoint-inhibitors
#19
REVIEW
Georgia Ntali, Eva Kassi, Maria Alevizaki
Cancer immunotherapy has introduced a novel class of drugs known as immune checkpoint inhibitors (ICIs). They enhance antitumour immunity by blocking negative regulators (checkpoints) of T cell function that exist on both immune and tumour cells. ICIs targeting CTLA-4 and PD-1/PDL-1 have dramatically changed the outcome of patients with several advanced-stage malignancies but they may lead to a variety of inflammatory toxicities and autoimmune consequences. The main endocrine immune-related adverse events (IRAEs) include hypophysitis, primary thyroid dysfunction, adrenalitis and type 1 diabetes mellitus...
October 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29512826/risk-factors-for-discontinuation-of-thyroid-hormone-replacement-therapy-in-early-pregnancy-a-study-from-the-norwegian-mother-and-child-cohort-study-and-the-medical-birth-registry-of-norway
#20
Anna S Frank, Angela Lupattelli, Hedvig Nordeng
INTRODUCTION: Approximately 3-5% of pregnant women have hypothyroidism. Despite the potential impact of untreated hypothyroidism on infant neurodevelopment, few studies have investigated the risk factors associated with discontinuation of thyroid hormone replacement therapy (THRT) in pregnancy. We aimed to identify such factors in a population of women using THRT prior to pregnancy. MATERIAL AND METHODS: Data from the Norwegian Mother and Child Cohort Study were linked to records in the Medical Birth Registry of Norway...
March 7, 2018: Acta Obstetricia et Gynecologica Scandinavica
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