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https://www.readbyqxmd.com/read/28723802/tocilizumab-for-uncontrollable-systemic-inflammatory-response-syndrome-complicating-adult-onset-still-disease-case-report-and-review-of-literature
#1
Asami Masui-Ito, Ryuji Okamoto, Kaoru Ikejiri, Mika Fujimoto, Muneyoshi Tanimura, Shiro Nakamori, Tomohiro Murata, Eiji Ishikawa, Norikazu Yamada, Hiroshi Imai, Masaaki Ito
RATIONALE: Adult-onset Still disease (AOSD) is a rare systemic inflammatory disease of unknown etiology characterized by evanescent salmon-pink rash, fever spikes, arthralgia, and lymphadenopathy. AOSD usually has a good prognosis, but it can sometimes be fatal, especially when it is complicated by systemic inflammatory response syndrome (SIRS) and multiple organ failure. PATIENT CONCERNS: A previously healthy 26-year-old woman was referred to our hospital for persistent high fever and mild systemic edema...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28721720/multicolor-tunable-luminescence-based-on-tb-3-eu-3-doping-through-a-facile-hydrothermal-route
#2
Chao Wang, Ting Zhou, Jing Jiang, Huiyuan Geng, Zhanglei Ning, Xin Lai, Jian Bi, Daojiang Gao
Ln(3+)-doped fluoride is a far efficient material for realizing multicolor emission, which plays an important part in full-color displays, biolabeling and MRI. However, studies on the multicolor tuning properties of Ln(3+)-doped fluoride are mainly concentrated on a complicated process using three or more dopants and the principle of energy transfer mechanism is still unclear. Herein, multicolor tunable emission is successfully obtained only by co-doping with Tb(3+) and Eu(3+) ions in β-NaGdF4 submicrocrystals via a facile hydrothermal route...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28717755/innovative-breast-cancer-awareness-and-advocacy-campaign
#3
Omolola Salako, Alero A Roberts, Victor I Isibor, Oluwatimilehin Babatunde, Omolara Fatiregun, Chukwumere N Nwogu
Breast cancer is a major disease in Nigeria; in 2012, 27,304 new occurrences were diagnosed, and the number of mortalities was 13,960. Greater than 70% of patients present with advanced disease, which has a poor survival outcome. The mortality rates are high mainly because of a lack of awareness about breast health, screening guidelines, and treatment centers, and because of sociocultural barriers. In Nigeria, health care professionals remain the backbone for the provision of medical information to the public...
April 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/28717426/extracellular-vesicles-released-following-heat-stress-induce-bystander-effect-in-unstressed-populations
#4
Findlay Bewicke-Copley, Laura Ann Mulcahy, Laura Ann Jacobs, Priya Samuel, Naveed Akbar, Ryan Charles Pink, David Raul Francisco Carter
Cells naïve to stress can display the effects of stress, such as DNA damage and apoptosis, when they are exposed to signals from stressed cells; this phenomenon is known as the bystander effect. We previously showed that bystander effect induced by ionising radiation are mediated by extracellular vesicles (EVs). Bystander effect can also be induced by other types of stress, including heat shock, but it is unclear whether EVs are involved. Here we show that EVs released from heat shocked cells are also able to induce bystander damage in unstressed populations...
2017: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/28716944/potent-competitive-inhibition-of-human-ribonucleotide-reductase-by-a-nonnucleoside-small-molecule
#5
Md Faiz Ahmad, Intekhab Alam, Sarah E Huff, John Pink, Sheryl A Flanagan, Donna Shewach, Tessianna A Misko, Nancy L Oleinick, William E Harte, Rajesh Viswanathan, Michael E Harris, Chris Godfrey Dealwis
Human ribonucleotide reductase (hRR) is crucial for DNA replication and maintenance of a balanced dNTP pool, and is an established cancer target. Nucleoside analogs such as gemcitabine diphosphate and clofarabine nucleotides target the large subunit (hRRM1) of hRR. These drugs have a poor therapeutic index due to toxicity caused by additional effects, including DNA chain termination. The discovery of nonnucleoside, reversible, small-molecule inhibitors with greater specificity against hRRM1 is a key step in the development of more effective treatments for cancer...
July 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28714844/puzihella-rosea-gen-nov-sp-nov-a-novel-member-of-the-family-microbacteriaceae-isolated-from-freshwater
#6
Shih-Yi Sheu, Li-Ping Liu, Wen-Ming Chen
Two Gram-stain-positive, aerobic, pink, curved, rod-shaped, non-motile bacterial strains, designated MI-28T and SKY-11, were isolated from freshwater samples taken from a river and fish pond, respectively. Based on characterization using a polyphasic approach, the two strains showed highly similar phenotypic, physiological and genetic profiles. They demonstrated 99.9 % 16S rRNA gene sequence similarity and a 93-95 % DNA-DNA relatedness value, suggesting that they represent a single genomic species. Phylogenetic analyses, based on 16S rRNA gene sequences, showed that strains MI-28T and SKY-11 form a distinct lineage with respect to closely related genera within the family Microbacteriaceae of the class Actinobacteria, which is most closely related to Rhodoluna and Pontimonas, and levels of 16S rRNA gene sequence similarity with the type species of related genera were less than 95 %...
July 17, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28712192/journey-from-black-to-pink-gums-management-of-melanin-induced-physiological-gingival-hyper-pigmentation
#7
Huma Farid, Muhammad Saad Shinwari, Farhan Raza Khan, Farzin Tanwir
Smile is an expression of happiness, self-confidence, kindness and beauty. Along with teeth and lips, gingiva is also a vital component of smile. Melanin induced gingival hyper pigmentation may appear un-aesthetic especially when it is associated with high smile line, upper anterior labial segment and is uneven in appearance. It affects individuals from all races. Generally, it is believed that melanin induced gingival hyper pigmentation is confined to individuals from dark races. But studies have shown that Iranian, Indian, Italian, Arabian, Greek...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28702960/buccal-bone-dimensions-and-aesthetic-outcome-at-maxillary-incisors-replaced-by-conventional-dental-implants-a-case-series-with-a-5-year-follow-up
#8
G B Menchini Fabris, S Marconcini, A Barone, E Velasco Ortega, E Bressan, P Balleri
In the aesthetic field, successful replacement of a tooth with a dental implant requires blend and harmony within the existing dentition. The influence of the dimension of buccal bone at implant sites on aesthetic outcomes and the relation between buccal bone horizontal and vertical dimensions are unclear. The aim of the present study is to investigate the correlation between buccal bone thickness, buccal bone level and aesthetic outcome in conventionally placed implants – placed five or more years previously – supporting single maxillary incisors...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28699724/toxicity-of-bacillus-thuringiensis-cry2ab-and-the-inheritance-of-cry2ab-resistance-in-the-pink-bollworm-pectinophora-gossypiella-saunders
#9
P A Malthankar, G T Gujar
Though the insecticidal crystal (Cry) proteins produced by Bacillus thuringiensis (Bt) are effective against insect pests, evolution of resistance remains an issue of great concern. Here, we explored the ability of pink bollworm, Pectinophora gossypiella (Lepidoptera: Gelechiidae), a key pest of cotton, to evolve resistance to Cry2Ab and characterized it in terms of inheritance. Sixteen day bioassay of Bt Cry2Ab toxin against 5-day old pink bollworm larvae showed median lethal concentration (LC(50)) ranging 0...
September 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/28699678/the-effect-of-furcation-involvement-on-tooth-loss-in-a-population-without-regular-periodontal-therapy
#10
Luigi Nibali, Anna Krajewski, Nikos Donos, Henry Völzke, Christiane Pink, Thomas Kocher, Birte Holtfreter
AIM: We aimed to assess the association between furcation involvement (FI) and tooth loss for subjects not undergoing regular periodontal treatment. MATERIALS AND METHODS: Data from 2333 subjects participating in the baseline and 11-year follow-up of the Study of Health in Pomerania (SHIP) were used. All subjects had half-mouth periodontal examinations, including FI in one upper and one lower molar, at baseline. A total of 1897 subjects and 3267 molars were included in the final analysis...
July 12, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28699259/increasing-temperature-cuts-back-crop-yields-in-hungary-over-the-last-90-years
#11
Zsolt Pinke, Gábor L Lövei
The transformation of climatic regime has an undeniable impact on plant production, but we rarely have long enough date series to examine the unfolding of such effects. The clarification of the relationship between crop plants and climate has a near-immediate importance due to the impending human-made global change. This study investigated the relationship between temperature, precipitation, drought intensity, and the yields of four major cereals in Hungary between 1921-2010. The analysis of 30-year segments indicated a monotonously increasing negative impact of temperature on crop yields...
July 12, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28691951/fatal-self-poisoning-with-massive-propranolol-ingestion-in-a-young-male-physician
#12
Supawon Srettabunjong
Suicidal intoxication from massive propranolol ingestion is rare. Surprisingly, no reported cases have involved physicians. The author herein reports a case of self-poisoning death due to ingestion of propranolol by a young male physician. A 31-year-old man with major depressive disorder was found dead in his dormitory room. Fifteen empty packages, each having contained ten 40-mg propranolol tablets, were found without any tablets leftover in his room. A suicide note was also found in his room. He was thus alleged to have ingested 6 g of propranolol for self-poisoning...
July 4, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28691666/hymenobacter-tenuis-sp-nov-isolated-from-wastewater-of-an-acidic-water-neutralization-facility
#13
Joo Won Kang, Ji Hee Lee, Han Na Choe, Chi Nam Seong
A non-motile, red-pink-coloured, rod-shaped bacterium, designated strain POB6T, was isolated from a wastewater treatment facility, Republic of Korea. Cells were Gram-stain-negative, aerobic, catalase-positive and oxidase-negative. The major fatty acids were iso-C15 : 0, C16 : 1ω5c, summed feature 3 (C16 : 1ω6c and/or C16 : 1ω7c) and summed feature 4 (iso-C17 : 1 I and/or anteiso-C17 : 1 B). The strain contained menaquinone MK-7 as the only isoprenoid quinone, phosphatidylethanolamine as the major polar lipid and sym-homospermidine as the major polyamine...
July 8, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28690556/sound-spectrum-influences-auditory-distance-perception-of-sound-sources-located-in-a-room-environment
#14
Ignacio Spiousas, Pablo E Etchemendy, Manuel C Eguia, Esteban R Calcagno, Ezequiel Abregú, Ramiro O Vergara
Previous studies on the effect of spectral content on auditory distance perception (ADP) focused on the physically measurable cues occurring either in the near field (low-pass filtering due to head diffraction) or when the sound travels distances >15 m (high-frequency energy losses due to air absorption). Here, we study how the spectrum of a sound arriving from a source located in a reverberant room at intermediate distances (1-6 m) influences the perception of the distance to the source. First, we conducted an ADP experiment using pure tones (the simplest possible spectrum) of frequencies 0...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28683369/aggregation-based-colorimetric-sensor-for-determination-of-prothioconazole-fungicide-using-colloidal-silver-nanoparticles-agnps
#15
Zahra Jafar-Nezhad Ivrigh, Nafiseh Fahimi-Kashani, M Reza Hormozi-Nezhad
There is a growing interest in developing high-performance sensors monitoring fungicides, due to their broadly usage and their adverse effects on humans and wildlife. In the present study, a colorimetric probe has been proposed for detection of prothioconazole based on aggregation of unmodified silver nanoparticles (AgNPs). Under optimized condition, linear relationships between the concentration of prothioconazole and the absorbance ratio of A500/A395 were found over the range of 0.01μg·mL(-1) to 0.4μg·mL(-1) with quantification limit as low as 1...
June 28, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28680419/novel-synechococcus-genomes-reconstructed-from-freshwater-reservoirs
#16
Pedro J Cabello-Yeves, Jose M Haro-Moreno, Ana-Belen Martin-Cuadrado, Rohit Ghai, Antonio Picazo, Antonio Camacho, Francisco Rodriguez-Valera
Freshwater picocyanobacteria including Synechococcus remain poorly studied at the genomic level, compared to their marine representatives. Here, using a metagenomic assembly approach we discovered two novel Synechococcus sp. genomes from two freshwater reservoirs Tous and Lake Lanier, both sharing 96% average nucleotide identity and displaying high abundance levels in these two lakes located at similar altitudes and temperate latitudes. These new genomes have the smallest estimated size (2.2 Mb) and average intergenic spacer length (20 bp) of any previously sequenced freshwater Synechococcus, which may contribute to their success in oligotrophic freshwater systems...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28678945/phagocytosis-and-nitric-oxide-production-by-peritoneal-adherent-cells-in-response-to-candida-albicans-in-aging-a-collaboration-to-elucidate-the-pathogenesis-of-denture-stomatitis
#17
Taiane Priscila Gardizani, Karen Henriette Pinke, Heliton Gustavo de Lima, Vanessa Soares Lara
Objective: The aim of this study was to investigate the influence of aging on the internalization and the production of nitric oxide (NO) by peritoneal adherent cells (PAC), in response to Candida albicans (C. albicans). Material and methods: PAC obtained from young and aged mice were challenged with dead or viable C. albicans by using predetermined proportions (cells:yeast) for 30 and 120 minutes. Phagocytosis was analyzed by acridine orange dye, and NO production by the Griess reaction...
May 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28677959/two-polymorphs-of-an-organic-zincophosphate-incorporating-a-terephthalate-bridging-ligand-in-an-unusual-bonding-mode
#18
Chih-Min Wang, Ming-Feng Pan, Yen-Chieh Chen, Hsiu-Mei Lin, Mei-Ying Chung, Yuh-Sheng Wen, Kwang-Hwa Lii
Two new polymorphs of a zinc phosphate incorporating the terephthalate organic ligand 1,4-benzenedicarboxylate (BDC), (H2DA)Zn2(cis-BDC)(HPO4)2 (1) and (H2DA)Zn2(trans-BDC)(HPO4)2 (2), where DA = 1,7-diaminoheptane, were synthesized via a hydro(solvo)thermal method at different reaction temperatures and structurally characterized by single-crystal X-ray diffraction. Interestingly, the BDC ligands, which adopt the bis-monodentate coordination model with a unusual cis type for compound 1 and with a trans linkage for compound 2, bridge the Zn atoms of the inorganic layers in the generation of two polymorphs with structural diversities (one kind of arrangement of the layered zincophosphate layer in 1; the flat and zigzag sheets of inorganic networks in 2)...
July 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28666205/re-examining-blood-donor-deferral-criteria-relating-to-injecting-drug-use
#19
Brendan Quinn, Clive Seed, Anthony Keller, Lisa Maher, David Wilson, Michael Farrell, Sharon Caris, Jennifer Williams, Annie Madden, Alexander Thompson, Joanne Pink, Margaret E Hellard
BACKGROUND AND AIMS: Potential Australian blood donors are deferred indefinitely if they report a history of injecting drug use (IDU), or for 12 months if they report having engaged in sexual activity with someone who might have ever injected. Given incremental improvements in blood safety, this study sought to examine whether Australia's IDU-related eligibility criteria reflected current scientific evidence, were consistent with international best practice and, if current IDU-related policies were to be changed, how this should happen...
June 27, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28665047/external-tooth-resorption-associated-with-a-peripheral-odontogenic-fibroma-review-and-case-report
#20
Geoffrey Sinclair Heithersay, Davide Musu, Elisabetta Cotti
The purpose of the study is to document a rare case of a peripheral odontogenic fibroma with associated cervical and coronal tooth resorption in a 38-year-old female. Histopathologic features are described, the clinical management outlined and follow-up observations over 27 years detailed. The exophytic firm lesion,coral pink in appearance, located on the labial aspect of a maxillary left lateral incisor was excised, fixed in formalin and prepared for histolologic evaluation. The resorption cavity and adjacent soft tissue were treated by the topical application of trichloracetic acid prior to restoration with a glass ionomer cement and subsequent root canal treatment...
June 30, 2017: Australian Dental Journal
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