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IASLC/ATS/ERS classification lung adenocarcinoma

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https://www.readbyqxmd.com/read/29065153/prognostic-implication-of-egfr-gene-mutations-and-histological-classification-in-patients-with-resected-stage-i-lung-adenocarcinoma
#1
Chun-Yu Lin, Yen-Mu Wu, Meng-Heng Hsieh, Chih-Wei Wang, Ching-Yang Wu, Ying-Jen Chen, Yueh-Fu Fang
INTRODUCTION: The prognostic value of epidermal growth factor receptor (EGFR) mutations and the correlation between EGFR mutations and the new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) histological classification remain controversial. The current study aimed to investigate the pure prognostic role of EGFR mutations in treatment-naïve patients with resected stage I lung adenocarcinoma. METHODS: We retrospectively reviewed 373 patients with stage I pulmonary non-small-cell lung cancer who underwent complete surgical resection between January 2010 and May 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28940943/associations-between-epidermal-growth-factor-receptor-mutations-and-histological-subtypes-of-lung-adenocarcinoma-according-to-the-iaslc-ats-ers-classification-in-chinese-patients
#2
Tengteng Wang, Yi Zhang, Baodong Liu, Mu Hu, Naikang Zhou, Xiuyi Zhi
BACKGROUND: This retrospective study was conducted to investigate the relationship between epidermal growth factor receptor (EGFR) mutation and histological subtypes of lung adenocarcinoma according to the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) classification in Chinese patients. METHODS: Three hundred and seventy six surgically resected lung adenocarcinomas from Chinese PLA General Hospital were included in the study...
November 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28935019/-advance-in-diagnose-and-treatment-strategies-of-adenocarcinoma-in-situ
#3
Yangbo Qiu, Yang Shen-Tu
Adenocarcinoma in situ (AIS) is a new concept which was introduced to the 2011 The International Association for the Study of Cancer (IASLC)/ American Thoracic Society (ATS)/ European Respiratory Society (ERS) International Multidisciplinary Classification of Lung Adenocarcinoma firstly and an important supplement of The 2015 World Health Organization Classification of Lung Tumors. Because AIS is at an early stage of development of lung adenocarcinoma, the deepening understanding of its pathology, differential diagnosis, treatment strategies, has an important significance for the improvement of the prognosis of lung adenocarcinoma...
September 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28834269/prognostic-significance-of-the-international-association-for-the-study-of-lung-cancer-american-thoracic-society-european-respiratory-society-classification-of-stage-i-lung-adenocarcinoma-a-retrospective-study-based-on-analysis-of-110-chinese-patients
#4
Xin Zhao, Yi Zhang, Kun Qian, Lan Zhao, Wei Wang, Liang H Teng
BACKGROUND: The aim of this study was to investigate the relationship between predominant subtype, classification, and prognosis in Chinese stage I lung adenocarcinoma patients according to the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) International Multidisciplinary Lung Adenocarcinoma Classification. METHODS: Between 2000 and 2010, 110 patients with stage I lung adenocarcinoma underwent surgery at Xuanwu Hospital...
November 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28616268/tumor-invasiveness-defined-by-iaslc-ats-ers-classification-of-ground-glass-nodules-can-be-predicted-by-quantitative-ct-parameters
#5
Qian-Jun Zhou, Zhi-Chun Zheng, Yong-Qiao Zhu, Pei-Ji Lu, Jia Huang, Jian-Ding Ye, Jie Zhang, Shun Lu, Qing-Quan Luo
BACKGROUND: To investigate the potential value of CT parameters to differentiate ground-glass nodules between noninvasive adenocarcinoma and invasive pulmonary adenocarcinoma (IPA) as defined by IASLC/ATS/ERS classification. METHODS: We retrospectively reviewed 211 patients with pathologically proved stage 0-IA lung adenocarcinoma which appeared as subsolid nodules, from January 2012 to January 2013 including 137 pure ground glass nodules (pGGNs) and 74 part-solid nodules (PSNs)...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28603066/differential-gene-expression-profiles-according-to-the-association-for-the-study-of-lung-cancer-american-thoracic-society-european-respiratory-society-histopathological-classification-in-lung-adenocarcinoma-subtypes
#6
COMPARATIVE STUDY
Camilo Molina-Romero, Claudia Rangel-Escareño, Alette Ortega-Gómez, Gerardo J Alanis-Funes, Alejandro Avilés-Salas, Federico Avila-Moreno, Gabriela E Mercado, Andrés F Cardona, Alfredo Hidalgo-Miranda, Oscar Arrieta
The current lung cancer classification from the Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society has considerably changed the pathologic diagnosis of lung invasive adenocarcinoma, identifying disease subtypes with substantial implications for medical practice, such as clinical, radiological, molecular, and prognostic differences. We analyzed the differences in the genetic expression of adenocarcinoma subtypes according to the new classification. Microarray gene expression analysis was performed on a cohort of 29 adenocarcinoma patients treated at the Instituto Nacional de Cancerología of Mexico from 2008 to 2011...
August 2017: Human Pathology
https://www.readbyqxmd.com/read/28593420/does-the-histologic-predominance-of-pathological-stage-ia-lung-adenocarcinoma-influence-the-extent-of-resection
#7
Hiroyuki Ito, Haruhiko Nakayama, Shuji Murakami, Tomoyuki Yokose, Kayoko Katayama, Yoshihiro Miyata, Morihito Okada
OBJECTIVES: We studied whether histologic subtype according to the new IASLC/ATS/ERS adenocarcinoma classification influences the extent of resection in patients with pathological stage IA lung adenocarcinoma. METHODS: Data on 288 patients with pathological stage IA lung adenocarcinoma were analyzed retrospectively. Recurrence-free survival (RFS) rates were compared according to clinicopathological characteristics, including predominant histologic subtype and extent of resection...
June 7, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28432617/prognostic-significance-of-histologic-subtype-in-pstage-i-lung-adenocarcinoma
#8
Nozomu Motono, Takuma Matsui, Yuichiro Machida, Katsuo Usuda, Hidetaka Uramoto
The International Association for the Study of Lung Cancer, the American Thoracic Society, and the European Respiratory Society (IASLC/ATS/ERS) proposed a new histologic classification of lung adenocarcinoma in 2011. While several studies have already validated the prognostic value of this new classification of lung adenocarcinoma, we conducted own investigation in the present study. This study included 197 patients with invasive lung adenocarcinoma who underwent complete resection. Pathologic diagnoses were made in accordance with the new IASLC/ATS/ERS classification for lung adenocarcinoma...
June 2017: Medical Oncology
https://www.readbyqxmd.com/read/28401582/histological-features-of-malignancy-correlate-with-growth-patterns-and-patient-outcome-in-lung-adenocarcinoma
#9
Johanna M Mäkinen, Kirsi Laitakari, Shirley Johnson, Riitta Mäkitaro, Risto Bloigu, Paavo Pääkkö, Elisa Lappi-Blanco, Riitta Kaarteenaho
AIMS: Until the launch of the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society adenocarcinoma classification in 2011, there were no uniform histological grading criteria for pulmonary adenocarcinomas. The current classification highlights the prognostic importance of the various histological growth patterns observed in these morphologically heterogeneous neoplasias. In this study, we aimed to evaluate the classic histological parameters of malignancy in correlation with the growth patterns and patient outcomes in a series of 112 surgically operated stage I-IV lung adenocarcinomas...
April 12, 2017: Histopathology
https://www.readbyqxmd.com/read/28331820/correlation-in-histological-subtypes-with-high-resolution-computed-tomography-signatures-of-early-stage-lung-adenocarcinoma
#10
Yingying Miao, Jianya Zhang, Jiawei Zou, Qingqing Zhu, Tangfeng Lv, Yong Song
BACKGROUND: Uncertainty remains on the association between image characteristics of the nodules in computed tomography (CT) scans and lung adenocarcinoma histopathologic subtypes. We aimed to estimate the correlation between preoperative high resolution computed tomography (HRCT) scan and postoperative histopathology of stage IA lung adenocarcinoma in East Asian Chinese population. METHODS: We retrospectively reviewed the clinical records and HRCT images of 190 patients (106 female and 84 male) with resected, preoperatively untreated stage IA adenocarcinomas...
February 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28043987/18f-fluorodeoxyglucose-positron-emission-tomographic-scan-in-solid-type-p-stage-i-pulmonary-adenocarcinomas-what-can-produce-false-negative-results
#11
Filippo Lococo, Carla Galeone, Debora Formisano, Salvatore Bellafiore, Angelina Filice, Tartaglione Annunziata, Alfredo Cesario, Cristian Rapicetta, Federica Fioroni, Tommaso Ricchetti, Massimiliano Paci
Objective: False-negative (FN) uptake of 18F-fluorodeoxyglucose (FDG) can be divided into those cases related to technological limitations of positron emission tomography (PET) and those related to inherent properties of neoplasms. Our goal was to clarify possible factors causing FN PET results in patients with solid-type pulmonary adenocarcinomas (PAs). Methods: From January 2007 to December 2014, of the 255 patients with p-stage-1 non-small-cell lung cancer observed and treated (surgically) in our institution, we retrospectively reviewed the PET/computed tomography (CT) records, the clinical information, the preoperative thin-section CT images, and the pathological features [classified by the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) subtyping criteria] of 94 consecutive solid-type p-stage-1 PAs...
April 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/27740967/kras-mutation-is-a-significant-prognostic-factor-in-early-stage-lung-adenocarcinoma
#12
Kyuichi Kadota, Camelia S Sima, Maria E Arcila, Cyrus Hedvat, Mark G Kris, David R Jones, Prasad S Adusumilli, William D Travis
The potential clinical impact of KRAS and epidermal growth factor receptor (EGFR) mutations has been investigated in lung adenocarcinomas; however, their prognostic value remains controversial. In our study, we sought to investigate the prognostic significance of driver mutations using a large cohort of early-stage lung adenocarcinomas. We reviewed patients with pathologic early-stage, lymph node-negative, solitary lung adenocarcinoma who had undergone surgical resection (1995 to 2005; stage I/II=463/19). Tumors were classified according to the IASLC/ATS/ERS classification and genotyped by Sequenom MassARRAY system and polymerase chain reaction-based assays...
December 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27545006/elucidating-genomic-characteristics-of-lung-cancer-progression-from-in-situ-to-invasive-adenocarcinoma
#13
Chanida Vinayanuwattikun, Florence Le Calvez-Kelm, Behnoush Abedi-Ardekani, David Zaridze, Anush Mukeria, Catherine Voegele, Maxime Vallée, Dewajani Purnomosari, Nathalie Forey, Geoffroy Durand, Graham Byrnes, James Mckay, Paul Brennan, Ghislaine Scelo
To examine the diversity of somatic alterations and clonal evolution according to aggressiveness of disease, nineteen tumor-blood pairs of 'formerly bronchiolo-alveolar carcinoma (BAC)' which had been reclassified into preinvasive lesion (adenocarcinoma in situ; AIS), focal invasive lesion (minimally invasive adenocarcinoma; MIA), and invasive lesion (lepidic predominant adenocarcinoma; LPA and non-lepidic predominant adenocarcinoma; non-LPA) according to IASLC/ATS/ERS 2011 classification were explored by whole exome sequencing...
August 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27524912/two-gene-signature-improves-the-discriminatory-power-of-iaslc-ats-ers-classification-to-predict-the-survival-of-patients-with-early-stage-lung-adenocarcinoma
#14
Yifeng Sun, Likun Hou, Yu Yang, Huikang Xie, Yang Yang, Zhigang Li, Heng Zhao, Wen Gao, Bo Su
BACKGROUND: In this study, we investigated the contribution of a gene expression-based signature (composed of BAG1, BRCA1, CDC6, CDK2AP1, ERBB3, FUT3, IL11, LCK, RND3, SH3BGR) to survival prediction for early-stage lung adenocarcinoma categorized by the new International Association for the Study of Lung Cancer (IASLC)/the American Thoracic Society (ATS)/the European Respiratory Society (ERS) classification. We also aimed to verify whether gene signature improves the risk discrimination of IASLC/ATS/ERS classification in early-stage lung adenocarcinoma...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27496649/the-histologic-classifications-of-lung-adenocarcinomas-are-discriminable-by-unique-lineage-backgrounds
#15
Haichuan Hu, Zhengliang Sun, Yuan Li, Yiliang Zhang, Hang Li, Yang Zhang, Yunjian Pan, Lei Shen, Rui Wang, Yihua Sun, Haiquan Chen
OBJECTIVES: Lung adenocarcinomas are a heterogeneous set of diseases with distinct genetic and histologic characteristics. Besides the discovery of oncogenic mutations and introduction of the histologic classifications (2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society and 2015 WHO), increasing evidence has linked this intertumor heterogeneity to the lung lineage-specific pathways and lineage genes. Therefore, in this study, we assessed the gene expression of identified lung lineage genes to study their role in distinguishing lung adenocarcinoma diversities...
December 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27456862/prognostic-value-of-mmp9-activity-level-in-resected-stage-i-b-lung-adenocarcinoma
#16
Yongfeng Yu, Zhengping Ding, Hong Jian, Lan Shen, Lei Zhu, Shun Lu
The clinical outcomes of patients with early-stage non-small cell lung cancer (NSCLC) have remained unsatisfactory after complete surgical resection. The objective of this study was to explore the prognostic value of matrix metalloproteinase 9 (MMP9) activity level in Chinese patients with stage I B lung adenocarcinoma. A sensitive and validated method was employed for determining the activity of MMP9 in human lung adenocarcinoma cells in vitro. Then, the association was examined between the level of MMP9 enzymatic activity and clinical outcomes...
September 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27401643/three-dimensional-ground-glass-opacity-ratio-in-ct-images-can-predict-tumor-invasiveness-of-stage-ia-lung-cancer
#17
Woo Sik Yu, Sae Rom Hong, Jin Gu Lee, Jae Seok Lee, Hee Suk Jung, Dae Joon Kim, Kyung Young Chung, Chang Young Lee
PURPOSE: We investigated the relationship between various parameters, including volumetric parameters, and tumor invasiveness according to the International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) classification. MATERIALS AND METHODS: We retrospectively reviewed 99 patients with completely resected stage IA lung adenocarcinoma. The correlation between several parameters [one-dimensional ground glass opacity (1D GGO) ratio, two-dimensional (2D) GGO ratio, three-dimensional (3D) GGO ratio, 1D solid size, 2D solid size, and 3D solid size] and tumor invasiveness according to IASLC/ATS/ERS classification was investigated using receiver operating characteristic (ROC) analysis...
September 2016: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27356985/-grading-of-lung-cancer
#18
REVIEW
R M Bohle, P A Schnabel
In comparison with other tumor entities there is no common generally accepted grading system for lung cancer with clearly defined criteria and clinical relevance. In the recent fourth edition of the World Health Organization (WHO) classification from 2015 of tumors of the lungs, pleura, thymus and heart, there is no generally applicable grading for pulmonary adenocarcinomas, squamous cell carcinomas or rarer forms of carcinoma. Since the new IASLC/ATS/ERS classification of adenocarcinomas published in 2011, 5 different subtypes with significantly different prognosis are proposed...
July 2016: Der Pathologe
https://www.readbyqxmd.com/read/27335291/-changes-of-2015-who-histological-classification-of-lung-cancer-%C3%A2-and-the-clinical-significance
#19
Xin Yang, Dongmei Lin
Due in part to remarkable advances over the past decade in our understanding of lung cancer, particularly in area of medical oncology, molecular biology, and radiology, there is a pressing need for a revised classification, based not on pathology alone, but rather on an integrated multidisciplinary approach to classification of lung cancer. The 2015 World Health Organization (WHO) Classification of Tumors of the Lung, Pleura, Thymus and Heart has just been published with numerous important changes from the 2004 WHO classification...
June 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27137345/lung-adenocarcinoma-staging-using-the-2011-iaslc-ats-ers-classification-a-pooled-analysis-of-adenocarcinoma-in-situ-and-minimally-invasive-adenocarcinoma
#20
REVIEW
Madhusmita Behera, Taofeek K Owonikoko, Anthony A Gal, Conor E Steuer, Sungjin Kim, Rathi N Pillai, Fadlo R Khuri, Suresh S Ramalingam, Gabriel L Sica
BACKGROUND: Lung adenocarcinoma accounts for almost 60% of non-small-cell lung cancer. According to the 2011 International Association for the Study of Lung Cancer (IASLC), American Thoracic Society (ATS), and European Respiratory Society (ERS) classification and 2015 World Health Organization classification of tumors of the lung, lepidic-predominant adenocarcinomas ≤ 3 cm in size can be classified as adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and invasive adenocarcinoma, lepidic predominant...
September 2016: Clinical Lung Cancer
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