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IASLC/ATS/ERS classification lung adenocarcinoma

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https://www.readbyqxmd.com/read/28616268/tumor-invasiveness-defined-by-iaslc-ats-ers-classification-of-ground-glass-nodules-can-be-predicted-by-quantitative-ct-parameters
#1
Qian-Jun Zhou, Zhi-Chun Zheng, Yong-Qiao Zhu, Pei-Ji Lu, Jia Huang, Jian-Ding Ye, Jie Zhang, Shun Lu, Qing-Quan Luo
BACKGROUND: To investigate the potential value of CT parameters to differentiate ground-glass nodules between noninvasive adenocarcinoma and invasive pulmonary adenocarcinoma (IPA) as defined by IASLC/ATS/ERS classification. METHODS: We retrospectively reviewed 211 patients with pathologically proved stage 0-IA lung adenocarcinoma which appeared as subsolid nodules, from January 2012 to January 2013 including 137 pure ground glass nodules (pGGNs) and 74 part-solid nodules (PSNs)...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28603066/differential-gene-expression-profiles-according-to-the-iaslc-ats-ers-histopathological-classification-in-lung-adenocarcinoma-subtypes
#2
Camilo Molina-Romero, Claudia Rangel-Escareño, Alette Ortega-Gómez, Gerardo J Alanis-Funes, Alejandro Aviles-Salas, Federico Avila-Moreno, Gabriela E Mercado, Andres F Cardona, Alfredo Hidalgo-Miranda, Oscar Arrieta
The current lung cancer classification from the Association for the Study of Lung Cancer (IASLC) / the American Thoracic Society (ATS)/ the European Respiratory Society (ERS) has considerably changed the pathologic diagnosis of lung invasive adenocarcinoma, identifying disease subtypes with substantial implications for medical practice, such as clinical, radiological, molecular and prognostic differences. We analyzed the differences in the genetic expression of adenocarcinoma subtypes according to the new classification...
June 8, 2017: Human Pathology
https://www.readbyqxmd.com/read/28593420/does-the-histologic-predominance-of-pathological-stage-ia-lung-adenocarcinoma-influence-the-extent-of-resection
#3
Hiroyuki Ito, Haruhiko Nakayama, Shuji Murakami, Tomoyuki Yokose, Kayoko Katayama, Yoshihiro Miyata, Morihito Okada
OBJECTIVES: We studied whether histologic subtype according to the new IASLC/ATS/ERS adenocarcinoma classification influences the extent of resection in patients with pathological stage IA lung adenocarcinoma. METHODS: Data on 288 patients with pathological stage IA lung adenocarcinoma were analyzed retrospectively. Recurrence-free survival (RFS) rates were compared according to clinicopathological characteristics, including predominant histologic subtype and extent of resection...
June 7, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28432617/prognostic-significance-of-histologic-subtype-in-pstage-i-lung-adenocarcinoma
#4
Nozomu Motono, Takuma Matsui, Yuichiro Machida, Katsuo Usuda, Hidetaka Uramoto
The International Association for the Study of Lung Cancer, the American Thoracic Society, and the European Respiratory Society (IASLC/ATS/ERS) proposed a new histologic classification of lung adenocarcinoma in 2011. While several studies have already validated the prognostic value of this new classification of lung adenocarcinoma, we conducted own investigation in the present study. This study included 197 patients with invasive lung adenocarcinoma who underwent complete resection. Pathologic diagnoses were made in accordance with the new IASLC/ATS/ERS classification for lung adenocarcinoma...
June 2017: Medical Oncology
https://www.readbyqxmd.com/read/28401582/histological-features-of-malignancy-correlate-with-growth-patterns-and-patient-outcome-in-lung-adenocarcinoma
#5
Johanna M Mäkinen, Kirsi Laitakari, Shirley Johnson, Riitta Mäkitaro, Risto Bloigu, Paavo Pääkkö, Elisa Lappi-Blanco, Riitta Kaarteenaho
AIMS: Until the launch of the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) adenocarcinoma classification in 2011, there were no uniform histological grading criteria for pulmonary adenocarcinomas. The current classification highlights the prognostic importance of the various histological growth patterns observed in these morphologically heterogeneous neoplasias. In this study, we aimed to evaluate the classic histological parameters of malignancy in correlation with the growth patterns and patient outcome in a series of 112 surgically operated stage I-IV lung adenocarcinomas...
April 12, 2017: Histopathology
https://www.readbyqxmd.com/read/28331820/correlation-in-histological-subtypes-with-high-resolution-computed-tomography-signatures-of-early-stage-lung-adenocarcinoma
#6
Yingying Miao, Jianya Zhang, Jiawei Zou, Qingqing Zhu, Tangfeng Lv, Yong Song
BACKGROUND: Uncertainty remains on the association between image characteristics of the nodules in computed tomography (CT) scans and lung adenocarcinoma histopathologic subtypes. We aimed to estimate the correlation between preoperative high resolution computed tomography (HRCT) scan and postoperative histopathology of stage IA lung adenocarcinoma in East Asian Chinese population. METHODS: We retrospectively reviewed the clinical records and HRCT images of 190 patients (106 female and 84 male) with resected, preoperatively untreated stage IA adenocarcinomas...
February 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28043987/18f-fluorodeoxyglucose-positron-emission-tomographic-scan-in-solid-type-p-stage-i-pulmonary-adenocarcinomas-what-can-produce-false-negative-results
#7
Filippo Lococo, Carla Galeone, Debora Formisano, Salvatore Bellafiore, Angelina Filice, Tartaglione Annunziata, Alfredo Cesario, Cristian Rapicetta, Federica Fioroni, Tommaso Ricchetti, Massimiliano Paci
OBJECTIVE: False-negative (FN) uptake of 18F-fluorodeoxyglucose (FDG) can be divided into those cases related to technological limitations of positron emission tomography (PET) and those related to inherent properties of neoplasms. Our goal was to clarify possible factors causing FN PET results in patients with solid-type pulmonary adenocarcinomas (PAs). METHODS: From January 2007 to December 2014, of the 255 patients with p-stage-1 non-small-cell lung cancer observed and treated (surgically) in our institution, we retrospectively reviewed the PET/computed tomography (CT) records, the clinical information, the preoperative thin-section CT images, and the pathological features [classified by the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) subtyping criteria] of 94 consecutive solid-type p-stage-1 PAs...
April 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/27740967/kras-mutation-is-a-significant-prognostic-factor-in-early-stage-lung-adenocarcinoma
#8
Kyuichi Kadota, Camelia S Sima, Maria E Arcila, Cyrus Hedvat, Mark G Kris, David R Jones, Prasad S Adusumilli, William D Travis
The potential clinical impact of KRAS and epidermal growth factor receptor (EGFR) mutations has been investigated in lung adenocarcinomas; however, their prognostic value remains controversial. In our study, we sought to investigate the prognostic significance of driver mutations using a large cohort of early-stage lung adenocarcinomas. We reviewed patients with pathologic early-stage, lymph node-negative, solitary lung adenocarcinoma who had undergone surgical resection (1995 to 2005; stage I/II=463/19). Tumors were classified according to the IASLC/ATS/ERS classification and genotyped by Sequenom MassARRAY system and polymerase chain reaction-based assays...
December 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27545006/elucidating-genomic-characteristics-of-lung-cancer-progression-from-in-situ-to-invasive-adenocarcinoma
#9
Chanida Vinayanuwattikun, Florence Le Calvez-Kelm, Behnoush Abedi-Ardekani, David Zaridze, Anush Mukeria, Catherine Voegele, Maxime Vallée, Dewajani Purnomosari, Nathalie Forey, Geoffroy Durand, Graham Byrnes, James Mckay, Paul Brennan, Ghislaine Scelo
To examine the diversity of somatic alterations and clonal evolution according to aggressiveness of disease, nineteen tumor-blood pairs of 'formerly bronchiolo-alveolar carcinoma (BAC)' which had been reclassified into preinvasive lesion (adenocarcinoma in situ; AIS), focal invasive lesion (minimally invasive adenocarcinoma; MIA), and invasive lesion (lepidic predominant adenocarcinoma; LPA and non-lepidic predominant adenocarcinoma; non-LPA) according to IASLC/ATS/ERS 2011 classification were explored by whole exome sequencing...
August 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27524912/two-gene-signature-improves-the-discriminatory-power-of-iaslc-ats-ers-classification-to-predict-the-survival-of-patients-with-early-stage-lung-adenocarcinoma
#10
Yifeng Sun, Likun Hou, Yu Yang, Huikang Xie, Yang Yang, Zhigang Li, Heng Zhao, Wen Gao, Bo Su
BACKGROUND: In this study, we investigated the contribution of a gene expression-based signature (composed of BAG1, BRCA1, CDC6, CDK2AP1, ERBB3, FUT3, IL11, LCK, RND3, SH3BGR) to survival prediction for early-stage lung adenocarcinoma categorized by the new International Association for the Study of Lung Cancer (IASLC)/the American Thoracic Society (ATS)/the European Respiratory Society (ERS) classification. We also aimed to verify whether gene signature improves the risk discrimination of IASLC/ATS/ERS classification in early-stage lung adenocarcinoma...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27496649/the-histologic-classifications-of-lung-adenocarcinomas-are-discriminable-by-unique-lineage-backgrounds
#11
Haichuan Hu, Zhengliang Sun, Yuan Li, Yiliang Zhang, Hang Li, Yang Zhang, Yunjian Pan, Lei Shen, Rui Wang, Yihua Sun, Haiquan Chen
OBJECTIVES: Lung adenocarcinomas are a heterogeneous set of diseases with distinct genetic and histologic characteristics. Besides the discovery of oncogenic mutations and introduction of the histologic classifications (2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society and 2015 WHO), increasing evidence has linked this intertumor heterogeneity to the lung lineage-specific pathways and lineage genes. Therefore, in this study, we assessed the gene expression of identified lung lineage genes to study their role in distinguishing lung adenocarcinoma diversities...
December 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27456862/prognostic-value-of-mmp9-activity-level-in-resected-stage-i-b-lung-adenocarcinoma
#12
Yongfeng Yu, Zhengping Ding, Hong Jian, Lan Shen, Lei Zhu, Shun Lu
The clinical outcomes of patients with early-stage non-small cell lung cancer (NSCLC) have remained unsatisfactory after complete surgical resection. The objective of this study was to explore the prognostic value of matrix metalloproteinase 9 (MMP9) activity level in Chinese patients with stage I B lung adenocarcinoma. A sensitive and validated method was employed for determining the activity of MMP9 in human lung adenocarcinoma cells in vitro. Then, the association was examined between the level of MMP9 enzymatic activity and clinical outcomes...
September 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27401643/three-dimensional-ground-glass-opacity-ratio-in-ct-images-can-predict-tumor-invasiveness-of-stage-ia-lung-cancer
#13
Woo Sik Yu, Sae Rom Hong, Jin Gu Lee, Jae Seok Lee, Hee Suk Jung, Dae Joon Kim, Kyung Young Chung, Chang Young Lee
PURPOSE: We investigated the relationship between various parameters, including volumetric parameters, and tumor invasiveness according to the International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) classification. MATERIALS AND METHODS: We retrospectively reviewed 99 patients with completely resected stage IA lung adenocarcinoma. The correlation between several parameters [one-dimensional ground glass opacity (1D GGO) ratio, two-dimensional (2D) GGO ratio, three-dimensional (3D) GGO ratio, 1D solid size, 2D solid size, and 3D solid size] and tumor invasiveness according to IASLC/ATS/ERS classification was investigated using receiver operating characteristic (ROC) analysis...
September 2016: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27356985/-grading-of-lung-cancer
#14
R M Bohle, P A Schnabel
In comparison with other tumor entities there is no common generally accepted grading system for lung cancer with clearly defined criteria and clinical relevance. In the recent fourth edition of the World Health Organization (WHO) classification from 2015 of tumors of the lungs, pleura, thymus and heart, there is no generally applicable grading for pulmonary adenocarcinomas, squamous cell carcinomas or rarer forms of carcinoma. Since the new IASLC/ATS/ERS classification of adenocarcinomas published in 2011, 5 different subtypes with significantly different prognosis are proposed...
July 2016: Der Pathologe
https://www.readbyqxmd.com/read/27335291/-changes-of-2015-who-histological-classification-of-lung-cancer-%C3%A2-and-the-clinical-significance
#15
Xin Yang, Dongmei Lin
Due in part to remarkable advances over the past decade in our understanding of lung cancer, particularly in area of medical oncology, molecular biology, and radiology, there is a pressing need for a revised classification, based not on pathology alone, but rather on an integrated multidisciplinary approach to classification of lung cancer. The 2015 World Health Organization (WHO) Classification of Tumors of the Lung, Pleura, Thymus and Heart has just been published with numerous important changes from the 2004 WHO classification...
June 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27137345/lung-adenocarcinoma-staging-using-the-2011-iaslc-ats-ers-classification-a-pooled-analysis-of-adenocarcinoma-in-situ-and-minimally-invasive-adenocarcinoma
#16
Madhusmita Behera, Taofeek K Owonikoko, Anthony A Gal, Conor E Steuer, Sungjin Kim, Rathi N Pillai, Fadlo R Khuri, Suresh S Ramalingam, Gabriel L Sica
BACKGROUND: Lung adenocarcinoma accounts for almost 60% of non-small-cell lung cancer. According to the 2011 International Association for the Study of Lung Cancer (IASLC), American Thoracic Society (ATS), and European Respiratory Society (ERS) classification and 2015 World Health Organization classification of tumors of the lung, lepidic-predominant adenocarcinomas ≤ 3 cm in size can be classified as adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and invasive adenocarcinoma, lepidic predominant...
March 30, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27103946/distribution-of-solid-solitary-pulmonary-nodules-within-the-lungs-on-computed-tomography-a-review-of-208-consecutive-lesions-of-biopsy-proven-nature
#17
Simone Perandini, Gianalberto Soardi, Massimiliano Motton, Eugenio Oliboni, Lisa Zantedeschi, Stefania Montemezzi
BACKGROUND: The solitary pulmonary nodule (SPN) is a common radiologic abnormality on chest x-rays or computed tomography (CT) scans of the lungs. The differential diagnosis of SPNs is particularly wide as it includes a multitude of benign as well as malignant entities. Nodule location within the lungs has been proposed as a predictive feature in the literature. This study aims at illustrating the distribution within the lungs of a large current series of consecutive SPNs according to their histological subtype, which was definitely proved at core biopsy...
2016: Polish Journal of Radiology
https://www.readbyqxmd.com/read/27073516/association-between-the-histological-subtype-of-lung-adenocarcinoma-egfr-kras-mutation-status-and-the-alk-rearrangement-according-to-the-novel-iaslc-ats-ers-classification
#18
Yu-Jie Dong, Yi-Ran Cai, Li-Juan Zhou, Dan Su, Jing Mu, Xue-Jing Chen, L I Zhang
The present study aimed to investigate the association between epidermal growth factor receptor (EGFR)/Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations, anaplastic lymphoma receptor tyrosine kinase (ALK) rearrangements and the morphological characteristics of lung adenocarcinoma (LAC), according to the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) classification in a large group of patients with primary LAC. A total of 200 patients with invasive LAC who had undergone complete resections at the Beijing Chest Hospital (Beijing, China) were randomly selected...
April 2016: Oncology Letters
https://www.readbyqxmd.com/read/27020204/associations-between-the-iaslc-ats-ers-lung-adenocarcinoma-classification-and-egfr-and-kras-mutations
#19
T D Clay, P A Russell, H Do, V Sundararajan, M Conron, G M Wright, A Dobrovic, M M Moore, S A McLachlan
We sought to investigate the frequency of mutations in epidermal growth factor receptor (EGFR) and Kirsten-RAS (KRAS) by each pathological subtype for patients with resected pulmonary adenocarcinoma as defined by the IASLC/ATS/ERS classification. Histological examination determined the predominant subtype according to the IASLC/ATS/ERS classification. EGFR and KRAS mutations were determined by high-resolution melting and Sanger sequencing. Clinical data were collected from medical records and clinicians. The 178 consecutive patients consisted of 48% males, median age 68 years (range 20-87) and smoking history 78%...
January 2016: Pathology
https://www.readbyqxmd.com/read/27004213/significance-of-iaslc-ats-ers-classification-for-early-stage-lung-adenocarcinoma-patients-in-predicting-benefit-from-adjuvant-chemotherapy
#20
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S Adusumilli
No abstract text is available yet for this article.
February 2016: Annals of Translational Medicine
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