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https://www.readbyqxmd.com/read/18852034/in-vitro-methylation-of-nuclear-respiratory-factor-2-binding-sites-suppresses-the-promoter-activity-of-the-human-tomm70-gene
#1
José R Blesa, Anita A Hegde, José Hernández-Yago
TOMM70 is a subunit of the outer mitochondrial membrane translocase that plays a major role as a receptor of hydrophobic preproteins targeted to mitochondria. We have previously reported that two binding sites for transcription factor NRF-2 in the promoter region of the human TOMM70 gene are essential in activating transcription (Blesa et al., Mitochondrion 2004; 3:251-59. Blesa et al., Biochem Cell Biol 2006; 84:813-22). This region contains thirteen CpG methylation sites, three of which occur in the sequence 5'-CCGG-3' that is specifically recognized by HpaII methylase which modifies the internal cytosine residue...
December 31, 2008: Gene
https://www.readbyqxmd.com/read/18364745/nrf-1-is-the-major-transcription-factor-regulating-the-expression-of-the-human-tomm34-gene
#2
José R Blesa, Jesús A Prieto-Ruiz, Beth A Abraham, Bridget L Harrison, Anita A Hegde, José Hernández-Yago
The human TOMM34 gene encodes a cytosolic protein with chaperone-like activity that helps import some preproteins to the mitochondria by keeping them in an unfolded, import-compatible state. TOMM34 was found to be upregulated frequently in colorectal tumors, suggesting that it also has a role in the growth of cancer cells. In this context, TOMM34 is a potential target for novel anticancer drugs, and it might also be used in the diagnosis of colorectal cancer. Nuclear respiratory factors (NRFs) play an important role in governing the nuclear-mitochondrial interactions implicated in mitochondrial biogenesis...
February 2008: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/17167546/distinct-functional-contributions-of-2-gabp-nrf-2-recognition-sites-within-the-context-of-the-human-tomm70-promoter
#3
José R Blesa, José Hernández-Yago
TOMM70 is a subunit of the outer mitochondrial membrane translocase that plays a major role as a receptor of hydrophobic preproteins targeted to mitochondria. We have previously reported 2 binding sites for the transcription factor GABP-NRF-2 in the promoter region of the human TOMM70 gene that are important in activating transcription. To assess the functionality and actual role of these sites, chromatin immunoprecipitation, site-directed mutagenesis, and electrophoretic mobility shift assays were carried out...
October 2006: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/16120358/nrf-2-transcription-factor-is-essential-in-promoting-human-tomm70-gene-expression
#4
José R Blesa, José M Hernández, José Hernández-Yago
TOMM70 is a subunit of the outer mitochondrial membrane translocase that plays a major role as a receptor of hydrophobic pre-proteins targeted to the mitochondria. We report the presence of two nuclear respiratory factor 2 (NRF-2) binding motifs in the 5'-flanking region of the human Tomm70 gene and establish their essential role for promoter activity by using reporter assays in HeLa cells. We show that both NRF-2 binding sites are functional and present evidence that interactions between these sites and a CpG island contribute to expression...
April 2004: Mitochondrion
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