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https://www.readbyqxmd.com/read/28081368/smart-metal-organic-framework-coatings-triggered-anti-biofilm-compound-release
#1
Birgit Claes, Tom Boudewijns, Laurens Muchez, Geert Hooyberghs, Erik V Van der Eycken, Jozef Vanderleyden, Hans P Steenackers, Dirk E De Vos
Metal-organic frameworks (MOFs) have a large potential for delivery of active molecules. Here, a MOF coating is investigated as a smart host matrix for triggered release of anti-biofilm compounds. Besides a coating consisting of the regular Fe-terephthalate MIL-88B(Fe), a new hydrophobic MIL-88B(Fe) coating is synthesized in hydrothermal conditions using palmitic acid as a lattice terminating group. These porous materials are used as a host matrix for the anti-biofilm compound 5-(4-chlorophenyl)-N-(2-isobutyl)-2-aminoimidazole, which has a specific biofilm inhibiting effect at concentrations at which no activity against planktonic cells is detected...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28077759/complex-responses-to-movement-based-disease-control-when-livestock-trading-helps
#2
Jamie C Prentice, Glenn Marion, Michael R Hutchings, Tom N McNeilly, Louise Matthews
Livestock disease controls are often linked to movements between farms, for example, via quarantine and pre- or post-movement testing. Designing effective controls, therefore, benefits from accurate assessment of herd-to-herd transmission. Household models of human infections make use of R*, the number of groups infected by an initial infected group, which is a metapopulation level analogue of the basic reproduction number R0 that provides a better characterization of disease spread in a metapopulation. However, existing approaches to calculate R* do not account for individual movements between locations which means we lack suitable tools for livestock systems...
January 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28072714/optical-coherence-tomography-assessment-of-a-complex-bifurcation-lesion-treated-with-double-kissing-crush-technique-a-case-report
#3
Jin-Zan Cai, Yao-Jun Zhang, Tian Xu, Yong-Xiang Zhu, Chen-Yu Mao, Christos V Bourantas, Tom Crake, Shao-Liang Chen
The DEFINITION (Impact of the complexity of bifurcation lesions treated with drug-eluting stents) study has provided a novel classification to evaluate the complexity of coronary bifurcation lesion according to coronary angiography, but angiographic imaging due to its low resolution and inherited limitation may result in an inaccurate adjudication.We used optical coherence tomography (OCT) to further evaluate the coronary characteristics in a patient with "simple" bifurcation lesion which was classified by the DEFINITION criteria...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28062450/the-structural-bioinformatics-library-modeling-in-biomolecular-science-and-beyond
#4
Frédéric Cazals, Tom Dreyfus
MOTIVATION: Software in structural bioinformatics has mainly been application driven. To favor practitioners seeking off-the-shelf applications, but also developers seeking advanced building blocks to develop novel applications, we undertook the design of the Structural Bioinformatics Library (SBL, http://sbl.inria.fr), a generic C ++/python cross-platform software library targeting complex problems in structural bioinformatics. Its tenet is based on a modular design offering a rich and versatile framework allowing the development of novel applications requiring well specified complex operations, without compromising robustness and performances...
January 5, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28062321/tom9-2-is-a-calmodulin-binding-protein-critical-for-tom-complex-assembly-but-not-for-mitochondrial-protein-import-in-arabidopsis-thaliana
#5
Nargis Parvin, Chris Carrie, Isabelle Pabst, Antonia Läßer, Debabrata Laha, Melanie Paul, Peter Geigenberger, Ralf Heermann, Kirsten Jung, Ute C Vothknecht, Fatima Chigri
The translocon on the outer membrane of mitochondria (TOM) facilitates import of nuclear encoded proteins. The principal machinery seems conserved in eukaryotes, however, divergence in composition and structure of TOM components has been observed between mammals, yeast and plants. TOM9, the plant homologue of yeast Tom22, is significantly smaller due to a truncation in the cytosolic receptor domain and its precise function is not understood. Here we provide evidences that TOM9.2 from Arabidopsis thaliana is involved in the formation of the mature TOM complex, most likely by influencing the assembly of the pore-forming subunit TOM40...
January 3, 2017: Molecular Plant
https://www.readbyqxmd.com/read/28059698/uk-national-data-guardian-for-health-and-care-s-review-of-data-security-trust-better-security-and-opt-outs
#6
Tom Chan, Concetta Tania Di Iorio, Simon De Lusignan, Daniel Lo Russo, Craig Kuziemsky, Siaw-Teng Liaw
Sharing health and social care data is essential to the delivery of high quality health care as well as disease surveillance, public health, and for conducting research. However, these societal benefits may be constrained by privacy and data protection principles. Hence, societies are striving to find a balance between the two competing public interests. Whilst the spread of IT advancements in recent decades has increased the demand for an increased privacy and data protection in many ways health is a special case...
December 20, 2016: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28057687/afresh-an-adaptive-framework-for-compression-of-reads-and-assembled-sequences-with-random-access-functionality
#7
Tom Paridaens, Glenn Van Wallendael, Wesley De Neve, Peter Lambert
MOTIVATION: The past decade has seen the introduction of new technologies that lowered the cost of genomic sequencing increasingly. We can even observe that the cost of sequencing is dropping significantly faster than the cost of storage and transmission. The latter motivates a need for continuous improvements in the area of genomic data compression, not only at the level of effectiveness (compression rate), but also at the level of functionality (e.g., random access), configurability (effectiveness vs complexity, coding tool set…), and versatility (support for both sequenced reads and assembled sequences)...
January 5, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28057044/tuberous-sclerosis-registry-to-increase-disease-awareness-tosca-baseline-data-on-2093-patients
#8
John C Kingswood, Guillaume B d'Augères, Elena Belousova, José C Ferreira, Tom Carter, Ramon Castellana, Vincent Cottin, Paolo Curatolo, Maria Dahlin, Petrus J de Vries, Martha Feucht, Carla Fladrowski, Gabriella Gislimberti, Christoph Hertzberg, Sergiusz Jozwiak, John A Lawson, Alfons Macaya, Rima Nabbout, Finbar O'Callaghan, Mirjana P Benedik, Jiong Qin, Ruben Marques, Valentin Sander, Matthias Sauter, Yukitoshi Takahashi, Renaud Touraine, Sotiris Youroukos, Bernard Zonnenberg, Anna C Jansen
BACKGROUND: Tuberous sclerosis complex (TSC) is a rare autosomal dominant genetic disorder. Many gaps remain in the understanding of TSC because of the complexity in clinical presentation. The TuberOus SClerosis registry to increase disease Awareness (TOSCA) is an international disease registry designed to address knowledge gaps in the natural history and management of TSC. Here, we present the baseline data of TOSCA cohort. METHODS: Patients of any age diagnosed with TSC, having a documented visit for TSC within the preceding 12 months, or newly diagnosed individuals were included...
January 5, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28052235/hybrid-methods-reveal-multiple-flexibly-linked-dna-polymerases-within-the-bacteriophage-t7-replisome
#9
Jamie R Wallen, Hao Zhang, Caroline Weis, Weidong Cui, Brittni M Foster, Chris M W Ho, Michal Hammel, John A Tainer, Michael L Gross, Tom Ellenberger
The physical organization of DNA enzymes at a replication fork enables efficient copying of two antiparallel DNA strands, yet dynamic protein interactions within the replication complex complicate replisome structural studies. We employed a combination of crystallographic, native mass spectrometry and small-angle X-ray scattering experiments to capture alternative structures of a model replication system encoded by bacteriophage T7. Two molecules of DNA polymerase bind the ring-shaped primase-helicase in a conserved orientation and provide structural insight into how the acidic C-terminal tail of the primase-helicase contacts the DNA polymerase to facilitate loading of the polymerase onto DNA...
January 3, 2017: Structure
https://www.readbyqxmd.com/read/28051091/evolutionary-conservation-and-in-vitro-reconstitution-of-microsporidian-iron-sulfur-cluster-biosynthesis
#10
Sven-A Freibert, Alina V Goldberg, Christian Hacker, Sabine Molik, Paul Dean, Tom A Williams, Sirintra Nakjang, Shaojun Long, Kacper Sendra, Eckhard Bill, Eva Heinz, Robert P Hirt, John M Lucocq, T Martin Embley, Roland Lill
Microsporidians are obligate intracellular parasites that have minimized their genome content and sub-cellular structures by reductive evolution. Here, we demonstrate that cristae-deficient mitochondria (mitosomes) of Trachipleistophora hominis are the functional site of iron-sulfur cluster (ISC) assembly, which we suggest is the essential task of these organelles. Cell fractionation, fluorescence imaging and immunoelectron microscopy demonstrate that mitosomes contain a complete pathway for [2Fe-2S] cluster biosynthesis that we biochemically reconstituted using purified mitosomal ISC proteins...
January 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/28046131/biological-recovery-of-platinum-complexes-from-diluted-aqueous-streams-by-axenic-cultures
#11
Synthia Maes, Ruben Props, Jeffrey P Fitts, Rebecca De Smet, Frank Vanhaecke, Nico Boon, Tom Hennebel
The widespread use of platinum in high-tech and catalytic applications has led to the production of diverse Pt loaded wastewaters. Effective recovery strategies are needed for the treatment of low concentrated waste streams to prevent pollution and to stimulate recovery of this precious resource. The biological recovery of five common environmental Pt-complexes was studied under acidic conditions; the chloro-complexes PtCl42- and PtCl62-, the amine-complex Pt(NH3)4Cl2 and the pharmaceutical complexes cisplatin and carboplatin...
2017: PloS One
https://www.readbyqxmd.com/read/28042965/molecular-simulations-identify-binding-poses-and-approximate-affinities-of-stapled-%C3%AE-%C3%AF-%C3%AF-helical-peptides-to-mdm2-and-mdmx
#12
Joseph A Morrone, Alberto Perez, Qiaolin Deng, Sookhee Nicole Ha, M Katharine Holloway, Tom K Sawyer, Bradley S Sherborne, Frank K Brown, Ken A Dill
Traditionally, computing the binding affinities of proteins to even relatively small and rigid ligands by free-energy methods has been challenging due to large computational costs and significant errors. Here, we apply a new molecular simulation acceleration method called MELD (Modeling by Employing Limited Data) to study the binding of stapled helical peptides to the MDM2 and MDMX proteins. We employ free energy based molecular dynamics simulations (MELD-MD) to identify binding poses and calculate binding affinities...
January 2, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28035920/using-drugs-as-molecular-probes-a%C3%A2-computational-chemical-biology-approach-in-neurodegenerative-diseases
#13
Mohammad Asif Emran Khan Emon, Alpha Tom Kodamullil, Reagon Karki, Erfan Younesi, Martin Hofmann-Apitius
Neurodegenerative diseases including Alzheimer's disease are complex to tackle because of the complexity of the brain, both in structure and function. Such complexity is reflected by the involvement of various brain regions and multiple pathways in the etiology of neurodegenerative diseases that render single drug target approaches ineffective. Particularly in the area of neurodegeneration, attention has been drawn to repurposing existing drugs with proven efficacy and safety profiles. However, there is a lack of systematic analysis of the brain chemical space to predict the feasibility of repurposing strategies...
December 30, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28035261/cellular-and-humoral-immunity-in-a-wild-mammal-variation-with-age-sex-and-association-with-overwinter-survival
#14
Rebecca L Watson, Tom N McNeilly, Kathryn A Watt, Josephine M Pemberton, Jill G Pilkington, Martin Waterfall, Phoebe R T Hopper, Daniel Cooney, Rose Zamoyska, Daniel H Nussey
Immune defenses are expected to be crucial for survival under the considerable parasite pressures experienced by wild animals. However, our understanding of the association between immunity and fitness in nature remains limited due to both the complexity of the vertebrate immune system and the often-limited availability of immune reagents in nonmodel organisms. Here, we use methods and reagents developed by veterinary researchers for domestic ungulates on blood samples collected from a wild Soay sheep population, to evaluate an unusually broad panel of immune parameters...
December 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28035071/heterogeneity-in-sarcoma-cell-lines-reveals-enhanced-motility-of-tetraploid-versus-diploid-cells
#15
Mohamed Jemaà, Samer Abdallah, Gwendaline Lledo, Gaelle Perot, Tom Lesluyes, Catherine Teyssier, Pierre Roux, Juliette van Dijk, Frederic Chibon, Ariane Abrieu, Nathalie Morin
Soft tissue sarcomas with complex genomics are very heterogeneous tumors lacking simple prognosis markers or targeted therapies. Overexpression of a subset of mitotic genes from a signature called CINSARC is of bad prognosis, but the significance of this signature remains elusive. Here we precisely measure the cell cycle and mitosis duration of sarcoma cell lines and we found that the mitotic gene products overexpression does not reflect variation in the time spent during mitosis or G2/M. We also found that the CINSARC cell lines, we studied, are composed of a mixture of aneuploid, diploid, and tetraploid cells that are highly motile in vitro...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/28031803/identifying-multispecies-synchrony-in-response-to-environmental-covariates
#16
Ben Swallow, Ruth King, Stephen T Buckland, Mike P Toms
The importance of multispecies models for understanding complex ecological processes and interactions is beginning to be realized. Recent developments, such as those by Lahoz-Monfort et al. (2011), have enabled synchrony in demographic parameters across multiple species to be explored. Species in a similar environment would be expected to be subject to similar exogenous factors, although their response to each of these factors may be quite different. The ability to group species together according to how they respond to a particular measured covariate may be of particular interest to ecologists...
December 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28018274/time-series-analysis-of-embodied-interaction-movement-variability-and-complexity-matching-as-dyadic-properties
#17
Leonardo Zapata-Fonseca, Dobromir Dotov, Ruben Fossion, Tom Froese
There is a growing consensus that a fuller understanding of social cognition depends on more systematic studies of real-time social interaction. Such studies require methods that can deal with the complex dynamics taking place at multiple interdependent temporal and spatial scales, spanning sub-personal, personal, and dyadic levels of analysis. We demonstrate the value of adopting an extended multi-scale approach by re-analyzing movement time-series generated in a study of embodied dyadic interaction in a minimal virtual reality environment (a perceptual crossing experiment)...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/28017360/estimation-of-daily-pm10-concentrations-in-italy-2006-2012-using-finely-resolved-satellite-data-land-use-variables-and-meteorology
#18
Massimo Stafoggia, Joel Schwartz, Chiara Badaloni, Tom Bellander, Ester Alessandrini, Giorgio Cattani, Francesca De' Donato, Alessandra Gaeta, Gianluca Leone, Alexei Lyapustin, Meytar Sorek-Hamer, Kees de Hoogh, Qian Di, Francesco Forastiere, Itai Kloog
Health effects of air pollution, especially particulate matter (PM), have been widely investigated. However, most of the studies rely on few monitors located in urban areas for short-term assessments, or land use/dispersion modelling for long-term evaluations, again mostly in cities. Recently, the availability of finely resolved satellite data provides an opportunity to estimate daily concentrations of air pollutants over wide spatio-temporal domains. Italy lacks a robust and validated high resolution spatio-temporally resolved model of particulate matter...
December 22, 2016: Environment International
https://www.readbyqxmd.com/read/28013541/electron-transfer-rates-in-host-guest-assemblies-at-%C3%AE-cyclodextrin-monolayers
#19
Alejandro Méndez-Ardoy, Tom Steentjes, Bernard A Boukamp, Pascal Jonkheijm, Tibor Kudernac, Jurriaan Huskens
The effect of the distance between a β-cyclodextrin (βCD) host core and a conductive substrate on the electron transfer rate of complexed guests as well as of free-diffusing electrochemically active probes has been studied. First we have evaluated a set of short tethered βCD adsorbates bearing different anchoring groups in order to get a reliable platform for the study of short-distance electron transfer. An electrochemically active trivalent guest was immobilized on these host monolayers in a selective and reversible manner, providing information about the packing density...
December 25, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27998262/neurocognitive-considerations-when-assessing-theory-of-mind-in-autism-spectrum-disorder
#20
Katie Hamilton, Michelle Hoogenhout, Susan Malcolm-Smith
Autism Spectrum Disorder (ASD) is characterised by poor social competence; and since Theory of Mind (ToM) is a building block for social-communicative skills and successful social integration, these skills are important to assess when preparing and monitoring educational and therapeutic plans. ToM is a complex skill requiring the ability to form mental concepts, to represent complex constructs verbally, to inhibit some mental states in favour of others, and to consider and compare multiple perspectives. It is critical to consider cognitive influences on the ability to develop and convey ToM skills to ensure that deficits in other cognitive domains do not falsely present as ToM deficits...
October 2016: Journal of Child and Adolescent Mental Health
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