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https://www.readbyqxmd.com/read/29141600/quantifying-the-need-for-enhanced-case-management-for-tb-patients-as-part-of-tb-cohort-audit-in-the-north-west-of-england-a-descriptive-study
#1
Angela Tucker, Jeniffer Mithoo, Paul Cleary, Mark Woodhead, Peter MacPherson, Tom Wingfield, Stefanie Davies, Carolyn Wake, Paddy McMaster, S Bertel Squire
BACKGROUND: Patients with TB have diverse and often challenging clinical and social needs that may hamper successful treatment outcomes. Understanding the need for additional support during treatment (enhanced case management, or ECM) is important for workforce capacity planning. North West England TB Cohort Audit (TBCA) has introduced a 4-level ECM classification system (ECM 0-3) to quantify the need for ECM in the region. This study describes the data from the first 2 years of ECM classification...
November 15, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29141018/evaluation-of-the-proliferation-marker-ki-67-in-a-large-prostatectomy-cohort
#2
Elin Richardsen, Sigve Andersen, Samer Al-Saad, Mehrdad Rakaee, Yngve Nordby, Mona Irene Pedersen, Nora Ness, Thea Grindstad, Ingeborg Movik, Tom Dønnem, Roy Bremnes, Lill-Tove Busund
The tumor proliferation index marker Ki-67 is strongly associated with tumor cell proliferation, growth and progression, and is widely used in routine clinicopathological investigation. Prostate cancer is a complex multifaceted and biologically heterogeneous disease, and overtreatment of localized, low volume indolent tumors, is evident. Here, we aimed to assess Ki-67 expression and related outcomes of 535 patients treated with radical prostatectomy. The percentage of tumor epithelial cells expressing Ki-67 was determined by immunohistochemical assay, both digital image analysis and visual scoring by light microscope were used for quantification...
2017: PloS One
https://www.readbyqxmd.com/read/29131884/seizures-and-encephalitis-in-myelin-oligodendrocyte-glycoprotein-igg-disease-vs-aquaporin-4-igg-disease
#3
Shahd H M Hamid, Dan Whittam, Mariyam Saviour, Amal Alorainy, Kerry Mutch, Samantha Linaker, Tom Solomon, Maneesh Bhojak, Mark Woodhall, Patrick Waters, Richard Appleton, Martin Duddy, Anu Jacob
Importance: Antibodies to myelin oligodendrocyte glycoprotein IgG (MOG-IgG) are increasingly detected in patients with non-multiple sclerosis-related demyelination, some of whom manifest a neuromyelitis optica (NMO) phenotype. Cortical involvement, encephalopathy, and seizures are rare in aquaporin 4 antibody (AQP4-IgG)-related NMO in the white European population. However, the authors encountered several patients with seizures associated with MOG-IgG disease. Objective: To compare incidence of seizures and encephalitis-like presentation, or both between AQP4-IgG-positive and MOG-IgG-positive patients...
November 13, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29112973/reading-wild-minds-a-computational-assay-of-theory-of-mind-sophistication-across-seven-primate-species
#4
Marie Devaine, Aurore San-Galli, Cinzia Trapanese, Giulia Bardino, Christelle Hano, Michel Saint Jalme, Sebastien Bouret, Shelly Masi, Jean Daunizeau
Theory of Mind (ToM), i.e. the ability to understand others' mental states, endows humans with highly adaptive social skills such as teaching or deceiving. Candidate evolutionary explanations have been proposed for the unique sophistication of human ToM among primates. For example, the Machiavellian intelligence hypothesis states that the increasing complexity of social networks may have induced a demand for sophisticated ToM. This type of scenario ignores neurocognitive constraints that may eventually be crucial limiting factors for ToM evolution...
November 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29112382/iron-ii-complexes-of-a-hemilabile-sns-amido-ligand-synthesis-characterization-and-reactivity
#5
Uttam K Das, Stephanie L Daifuku, Theresa E Iannuzzi, Serge I Gorelsky, Ilia Korobkov, Bulat Gabidullin, Michael L Neidig, R Tom Baker
We report an easily prepared bis(thioether) amine ligand, S(Me)N(H)S(Me), along with the synthesis, characterization, and reactivity of the paramagnetic iron(II) bis(amido) complex, [Fe(κ(3)-S(Me)NS(Me))2] (1). Binding of the two different thioethers to Fe generates both five- and six-membered rings with Fe-S bonds in the five-membered rings (av 2.54 Å) being significantly shorter than those in the six-membered rings (av 2.71 Å), suggesting hemilability of the latter thioethers. Consistent with this hypothesis, magnetic circular dichroism (MCD) and computational (TD-DFT) studies indicate that 1 in solution contains a five-coordinate component [Fe(κ(3)-S(Me)NS(Me))(κ(2)-S(Me)NS(Me))] (2)...
November 7, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29110830/long-term-outcomes-of-pediatric-intestinal-failure
#6
Brenna S Fullerton, Charles R Hong, Tom Jaksic
Management of pediatric intestinal failure has evolved in recent decades, with improved survival since the advent of specialized multidisciplinary intestinal failure centers. Though sepsis and intestinal failure associated liver disease still contribute to mortality, we now have growing data on the long-term outcomes for this population. While intestinal adaptation and parenteral nutrition weaning is most rapid during the first year on parenteral support, achievement of enteral autonomy is possible even after many years as energy and protein requirements decline dramatically with age...
October 2017: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/29104372/genetic-algorithm-learning-in-a-new-keynesian-macroeconomic-setup
#7
Cars Hommes, Tomasz Makarewicz, Domenico Massaro, Tom Smits
In order to understand heterogeneous behavior amongst agents, empirical data from Learning-to-Forecast (LtF) experiments can be used to construct learning models. This paper follows up on Assenza et al. (2013) by using a Genetic Algorithms (GA) model to replicate the results from their LtF experiment. In this GA model, individuals optimize an adaptive, a trend following and an anchor coefficient in a population of general prediction heuristics. We replicate experimental treatments in a New-Keynesian environment with increasing complexity and use Monte Carlo simulations to investigate how well the model explains the experimental data...
2017: Journal of Evolutionary Economics
https://www.readbyqxmd.com/read/29093663/selection-and-characterization-of-palmitic-acid-responsive-patients-with-an-oxphos-complex-i-defect
#8
Tom E J Theunissen, Mike Gerards, Debby M E I Hellebrekers, Florence H van Tienen, Rick Kamps, Suzanne C E H Sallevelt, Elvira N M M-D Hartog, Hans R Scholte, Robert M Verdijk, Kees Schoonderwoerd, Irenaeus F M de Coo, Radek Szklarczyk, Hubert J M Smeets
Mitochondrial disorders are genetically and clinically heterogeneous, mainly affecting high energy-demanding organs due to impaired oxidative phosphorylation (OXPHOS). Currently, effective treatments for OXPHOS defects, with complex I deficiency being the most prevalent, are not available. Yet, clinical practice has shown that some complex I deficient patients benefit from a high-fat or ketogenic diet, but it is unclear how these therapeutic diets influence mitochondrial function and more importantly, which complex I patients could benefit from such treatment...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29093542/htra1-activation-is-driven-by-an-allosteric-mechanism-of-inter-monomer-communication
#9
Alvaro Cortes Cabrera, Esther Melo, Doris Roth, Andreas Topp, Frederic Delobel, Corinne Stucki, Chia-Yi Chen, Peter Jakob, Balazs Banfai, Tom Dunkley, Oliver Schilling, Sylwia Huber, Roberto Iacone, Paula Petrone
The human protease family HtrA is responsible for preventing protein misfolding and mislocalization, and a key player in several cellular processes. Among these, HtrA1 is implicated in several cancers, cerebrovascular disease and age-related macular degeneration. Currently, HtrA1 activation is not fully characterized and relevant for drug-targeting this protease. Our work provides a mechanistic step-by-step description of HtrA1 activation and regulation. We report that the HtrA1 trimer is regulated by an allosteric mechanism by which monomers relay the activation signal to each other, in a PDZ-domain independent fashion...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29093462/generalized-phase-mixing-turbulence-like-behaviour-from-unidirectionally-propagating-mhd-waves
#10
Norbert Magyar, Tom Van Doorsselaere, Marcel Goossens
We present the results of three-dimensional (3D) ideal magnetohydrodynamics (MHD) simulations on the dynamics of a perpendicularly inhomogeneous plasma disturbed by propagating Alfvénic waves. Simpler versions of this scenario have been extensively studied as the phenomenon of phase mixing. We show that, by generalizing the textbook version of phase mixing, interesting phenomena are obtained, such as turbulence-like behavior and complex current-sheet structure, a novelty in longitudinally homogeneous plasma excited by unidirectionally propagating waves...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29091802/consequences-of-ph-change-on-wastewater-depth-filtration-using-a-multimedia-filter
#11
Philani Ncube, Marc Pidou, Tom Stephenson, Bruce Jefferson, Peter Jarvis
Different media materials in a multimedia filter have the potential to trap particles of different characteristics dependent on the media-suspension particle interactions. However, the removal of particles from wastewater secondary effluent using granular media filtration is relatively poorly understood because of the complexity of the wastewater matrix. Often the wastewater treatment process is liable to undergo pH changes due to removal or addition of chemicals in the treatment chain or from biological instability which in turn may alter the wastewater characteristics...
October 21, 2017: Water Research
https://www.readbyqxmd.com/read/29078694/special-issue-on-complex-aerodigestive-endoscopy
#12
David Tom Cooke
No abstract text is available yet for this article.
2017: J Vis Surg
https://www.readbyqxmd.com/read/29061965/hierarchical-control-of-enzymatic-actuators-using-dna-based-switchable-memories
#13
Lenny H H Meijer, Alex Joesaar, Erik Steur, Wouter Engelen, Rutger A van Santen, Maarten Merkx, Tom F A de Greef
Inspired by signaling networks in living cells, DNA-based programming aims for the engineering of biochemical networks capable of advanced regulatory and computational functions under controlled cell-free conditions. While regulatory circuits in cells control downstream processes through hierarchical layers of signal processing, coupling of enzymatically driven DNA-based networks to downstream processes has rarely been reported. Here, we expand the scope of molecular programming by engineering hierarchical control of enzymatic actuators using feedback-controlled DNA-circuits capable of advanced regulatory dynamics...
October 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/29061621/detection-and-management-of-familial-hypercholesterolaemia-in-primary-care-in-australia-protocol-for-a-pragmatic-cluster-intervention-study-with-pre-post-intervention-comparisons
#14
Diane E Arnold-Reed, Tom Brett, Lakkhina Troeung, Alistair Vickery, Jacquie Garton-Smith, Damon Bell, Jing Pang, Tegan Grace, Caroline Bulsara, Ian Li, Max Bulsara, Gerald F Watts
INTRODUCTION: Familial hypercholesterolaemia (FH), an autosomal dominant disorder of lipid metabolism, results in accelerated onset of atherosclerosis if left untreated. Lifelong treatment with diet, lifestyle modifications and statins enable a normal lifespan for most patients. Early diagnosis is critical. This protocol trials a primary care-based model of care (MoC) to improve detection and management of FH. METHODS AND ANALYSIS: Pragmatic cluster intervention study with pre-post intervention comparisons in Australian general practices...
October 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29061094/modelling-and-simulating-decision-processes-of-linked-lives-an-approach-based-on-concurrent-processes-and-stochastic-race
#15
Tom Warnke, Oliver Reinhardt, Anna Klabunde, Frans Willekens, Adelinde M Uhrmacher
Individuals' decision processes play a central role in understanding modern migration phenomena and other demographic processes. Their integration into agent-based computational demography depends largely on suitable support by a modelling language. We are developing the Modelling Language for Linked Lives (ML3) to describe the diverse decision processes of linked lives succinctly in continuous time. The context of individuals is modelled by networks the individual is part of, such as family ties and other social networks...
October 2017: Population Studies
https://www.readbyqxmd.com/read/29058709/molecular-analysis-of-prc2-recruitment-to-dna-in-chromatin-and-its-inhibition-by-rna
#16
Xueyin Wang, Richard D Paucek, Anne R Gooding, Zachary Z Brown, Eva J Ge, Tom W Muir, Thomas R Cech
Many studies have revealed pathways of epigenetic gene silencing by Polycomb repressive complex 2 (PRC2) in vivo, but understanding the underlying molecular mechanisms requires biochemistry. Here we analyze interactions of reconstituted human PRC2 with nucleosome complexes. Histone modifications, the H3K27M cancer mutation, and inclusion of JARID2 or EZH1 in the PRC2 complex have unexpectedly minor effects on PRC2-nucleosome binding. Instead, protein-free linker DNA dominates the PRC2-nucleosome interaction...
October 23, 2017: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/29040646/statins-affect-skeletal-muscle-performance-evidence-for-disturbances-in-energy-metabolism
#17
Neeltje A E Allard, Tom J J Schirris, Rebecca J Verheggen, Frans G M Russel, Richard J Rodenburg, Jan A M Smeitink, Paul D Thompson, Maria T E Hopman, Silvie Timmers
Context: Statin myopathy is linked to disturbances in mitochondrial function and exercise intolerance. Objectives: To determine whether differences exist in exercise performance, muscle function and mitochondrial oxidative capacity and content between symptomatic and asymptomatic statin users, and non-statin using controls. Design: Cross-sectional study. Setting: Department of Physiology of the Radboud University Medical Center...
October 9, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29033880/exploring-the-multi-layered-affordances-of-composing-and-performing-interactive-music-with-responsive-technologies
#18
Anna Einarsson, Tom Ziemke
The question motivating the work presented here, starting from a view of music as embodied and situated activity, is how can we account for the complexity of interactive music performance situations. These are situations in which human performers interact with responsive technologies, such as sensor-driven technology or sound synthesis affected by analysis of the performed sound signal. This requires investigating in detail the underlying mechanisms, but also providing a more holistic approach that does not lose track of the complex whole constituted by the interactions and relationships of composers, performers, audience, technologies, etc...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29025835/the-climb-complex-lipids-in-mothers-and-babies-study-protocol-for-a-multicentre-three-group-parallel-randomised-controlled-trial-to-investigate-the-effect-of-supplementation-of-complex-lipids-in-pregnancy-on-maternal-ganglioside-status-and-subsequent-cognitive
#19
Shuai Huang, Ting-Ting Mo, Tom Norris, Si Sun, Ting Zhang, Ting-Li Han, Angela Rowan, Yin-Yin Xia, Hua Zhang, Hong-Bo Qi, Philip N Baker
INTRODUCTION: Complex lipids are important constituents of the central nervous system. Studies have shown that supplementation with complex milk lipids (CML) in pregnancy may increase the level of fetal gangliosides (GA), with the potential to improve cognitive outcomes. METHODS AND ANALYSIS: We aim to recruit approximately 1500 pregnant women in the first trimester (11-14 weeks) and randomise them into one of the three treatment groups: standard maternal milk formulation, CML-enhanced maternal milk formulation or no maternal milk intervention with standard pregnancy advice (ie, the standard care)...
October 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29018081/platelet-interaction-with-activated-endothelium-mechanistic-insights-from-microfluidics
#20
Daniëlle M Coenen, Tom G Mastenbroek, Judith M E M Cosemans
Traditionally, in vitro flow chamber experiments and in vivo arterial thrombosis studies have been proven to be of vital importance to elucidate the mechanisms of platelet thrombus formation after vessel wall injury. In recent years, it has become clear that platelets also act as modulators of inflammatory processes, such as atherosclerosis. A key element herein is the complex crosstalk between platelets, the coagulation system, leukocytes and the activated endothelium. This review provides insight into the platelet-endothelial interface, based on in vitro flow chamber studies and cross referenced with in vivo thrombosis studies...
October 10, 2017: Blood
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