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Osteoporosis elderly

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https://www.readbyqxmd.com/read/28229037/long-term-effects-of-a-ten-year-osteoporosis-intervention-program-in-a-swedish-population-a-cross-sectional-study
#1
Ann-Charlotte Grahn Kronhed, Helena Salminen
The aim of the study was to explore long-term effects seven years after the completion of a ten-year community-based osteoporosis intervention program in Vadstena, Sweden. The association between calcaneal bone mineral density and several life style factors, and the impact of risk factors for sustaining a fracture after the age of 50 were also studied. Previous participants in the intervention group, and matched subjects were invited to calcaneal bone mass measurement by a portable device including the dual X-ray and laser (DXL) technology by Calscan, and to complete a questionnaire in 2006...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28224090/vitamin-d-deficiency-insufficiency-from-childhood-to-adulthood-insights-from-a-sunny-country
#2
REVIEW
Motti Haimi, Richard Kremer
Vitamin D is known to be a key regulator of bone metabolism and is associated with muscle strength. Vitamin D deficiency is widely prevalent worldwide. In adults, vitamin D deficiency has been implicated in numerous health conditions including osteoporosis, cancer, diabetes, and autoimmune diseases. Considerable changes have occurred in lifestyles and childhood activities in the past years. Studies have shown that the children population is at high risks of vitamin D deficiency. The objective of this study was to learn about the extent of vitamin D deficiency in children worldwide and especially in sunny country like Israel...
February 8, 2017: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/28215116/micro-computed-tomography-and-mechanical-evaluation-of-trabecular-bone-structure-in-osteopenic-and-osteoporotic-fractures
#3
Fırat Ozan, Mahmut Pekedis, Şemmi Koyuncu, Taşkın Altay, Hasan Yıldız, Cemil Kayalı
PURPOSE: Osteopenia and osteoporosis are the two most common musculoskeletal disorders in the elderly population. We determined whether osteopenic and osteoporotic patients with fractures exhibit differences in trabecular morphology and biomechanical properties of bone. METHODS: Fourteen osteopenic patients and 28 osteoporotic patients with hip fractures who underwent hemiarthroplasty for proximal femoral fractures caused by low-energy injury were included. Bone mineral density (BMD) measurements were performed...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28210776/cost-effectiveness-of-denosumab-versus-oral-alendronate-for-elderly-osteoporotic-women-in-japan
#4
T Mori, C J Crandall, D A Ganz
: We constructed a Markov microsimulation model among hypothetical cohorts of community-dwelling elderly osteoporotic Japanese women without prior hip or vertebral fractures over a lifetime horizon. Compared with weekly oral alendronate for 5 years, denosumab every 6 months for 5 years is cost-saving or cost-effective at a conventionally accepted threshold. INTRODUCTION: The objective of the study was to examine the cost-effectiveness of subcutaneous denosumab every 6 months for 5 years compared with weekly oral alendronate for 5 years in Japan...
February 17, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28202082/bone-morphogenetic-proteins-and-myostatin-pathways-key-mediator-of-human-sarcopenia
#5
Manuel Scimeca, Eleonora Piccirilli, Francesca Mastrangeli, Cecilia Rao, Maurizio Feola, Augusto Orlandi, Elena Gasbarra, Elena Bonanno, Umberto Tarantino
BACKGROUND: Sarcopenia, osteoporosis and osteoarthritis are the most frequent musculoskeletal disorders affecting older people. The main aim of this study was to test the hypothesis that the balance between BMPs and myostatin pathways regulates the age-related muscle degeneration in OP and OA patients. To this end, we investigated the relationship among the expression of BMP-2/4-7, myostatin and phosphorylated Smads1-5-8 and the muscle quality, evaluated in term of fibers atrophy and satellite cells activity...
February 15, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28198990/corticosteroids-and-hip-fracture-risk-in-elderly-respiratory-patients-epic-greece-cohort
#6
Anna Karakatsani, Michail Katsoulis, Eleni Klinaki, Antonia Trichopoulou
INTRODUCTION: In an ageing population the prevalence of osteoporosis and chronic respiratory diseases is expected to increase in the near future. Interestingly, several forms of corticosteroids, drugs implicated in osteoporosis pathogenesis, are prescribed to respiratory patients without taking into consideration their age and risk for osteoporotic fractures. The aim of this study was to investigate the risk for hip fracture of the elder individuals who are taking corticosteroids for respiratory disease, including inhalers...
2017: Adv Respir Med
https://www.readbyqxmd.com/read/28193296/comparison-between-clinical-significance-of-height-adjusted-and-weight-adjusted-appendicular-skeletal-muscle-mass
#7
Taishi Furushima, Motohiko Miyachi, Motoyuki Iemitsu, Haruka Murakami, Hiroshi Kawano, Yuko Gando, Ryoko Kawakami, Kiyoshi Sanada
BACKGROUND: This study aimed to compare relationships between height- or weight-adjusted appendicular skeletal muscle mass (ASM/Ht(2) or ASM/Wt) and risk factors for cardiometabolic diseases or osteoporosis in Japanese men and women. METHODS: Subjects were healthy Japanese men (n = 583) and women (n = 1218). The study population included a young group (310 men and 357 women; age, 18-40 years) and a middle-aged and elderly group (273 men and 861 women; age, ≥41 years)...
February 13, 2017: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/28178601/bone-health-among-older-adults-in-taiwan
#8
Wei-Jen Wang, Kuan-Liang Kuo, Chen-Kun Liaw, Tai-Yin Wu, Wei-Chu Chie, Jer-Min Chen
BACKGROUND AND PURPOSE: There has been much discussion about the risk factors for osteoporosis, but studies involving elderly population in Taiwan are minimal. We aimed to describe variables related to osteoporosis among community dwelling older people in Taiwan. METHODS: This is a cross-sectional study. The 671 participants were randomly selected from 3680 examinees of the annual Senior Citizens Health Examination in year 2010. Participants were interviewed with a detailed questionnaire, and 91 of them were invited for dual-energy X-ray absorptiometry (DXA)...
January 12, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28164198/sialoglycoprotein-isolated-from-the-eggs-of-gadus-morhua-enhances-fracture-healing-in-osteoporotic-mice
#9
Qiping Zhan, Xiong Gui, Fei Wang, Peng Yu, Meihui Zhao, Jingfeng Wang, Changhu Xue
Osteoporosis is a common disease in the elderly, which is related to fracture healing delay. In this study, the effects of treatment with sialoglycoprotein isolated from the eggs of Gadus morhua (Gm-SGP) on tibial fracture healing in ovariectomized (OVX) osteoporotic female C57BL/6J mice for 56 days post-fracture were investigated. The result showed that Gm-SGP treatment significantly increased serum angiogenic factors and bone formation markers on day 5 and 11 post-fracture when compared with the OVX group...
February 6, 2017: Food & Function
https://www.readbyqxmd.com/read/28163951/a-review-on-the-relationship-between-aspirin-and-bone-health
#10
REVIEW
Kok-Yong Chin
Aspirin is a cyclooxygenase inhibitor commonly used in primary prevention of cardiovascular diseases and cancers. Its users are elderly population susceptible to osteoporosis. It also inhibits the synthesis of prostaglandin E2 essential in bone remodeling. This prompts the question whether it can influence bone health among users. This review aimed to summarize the current literature on the use of aspirin on bone health. A literature search on experimental and clinical evidence on the effects of aspirin on bone health was performed using major scientific databases...
2017: Journal of Osteoporosis
https://www.readbyqxmd.com/read/28163861/cost-effectiveness-of-zoledronic-acid-to-prevent-and-treat-postmenopausal-osteoporosis-in-comparison-with-routine-medical-treatment
#11
Fateme Rostami Golmohamdi, Mahnaz Abbasi, Ali Kazemi Karyani, Ali Akbari Sari
INTRODUCTION: Fractures caused by osteoporosis are prevalent among elderly females, which reduce quality of life significantly. This study aimed at comparing cost-effectiveness of Zoledronic acid in preventing and treating post-menopause osteoporosis as compared with routine medical treatment. METHODS: This cost-effectiveness study was carried out retrospectively from the Ministry of Health and insurance organizations perspective. Costs were evaluated based on the cost estimation of a sample of patients...
December 2016: Electronic Physician
https://www.readbyqxmd.com/read/28162775/association-between-sleep-duration-and-osteoporosis-risk-in-middle-aged-and-elderly-women-a-systematic-review-and-meta-analysis-of-observational-studies
#12
REVIEW
Sajjad Moradi, Sakineh Shab-Bidar, Shahab Alizadeh, Kurosh Djafarian
OBJECTIVE: Increasing evidence has suggested an association between sleep duration and osteoporosis risk, although the results of previous studies have been inconsistent. To our knowledge, this is the first meta-analysis of the literature and quantitative estimates of the association between sleep duration and risk of osteoporosis in population-based studies of middle aged and elderly women. METHODS: Pertinent studies were identified by searching PubMed and EMBASE databases up to February 2016...
January 26, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28161839/osteoprotegerin-and-uremic-osteoporosis-in-chronic-hemodialysis-patients
#13
Diana Moldovan, Crina Rusu, Alina Potra, Ioan Moldovan, Ioan Mihai Patiu, Mirela Gherman-Caprioara, Ina Maria Kacso
INTRODUCTION: Osteoprotegerin (OPG) is a powerful inhibitor of osteoclast activity, and it plays an important role in bone metabolism. In hemodialysis (HD) patients, the relationship between OPG and bone mineral density (BMD) is important, but remains unclear yet. The study objective was to assess the OPG role related to uremic osteoporosis in HD patients. METHODS: This cross-sectional study has been realized on a cohort of 63 chronic HD patients. INCLUSION CRITERIA: elderly prevalent HD patients with an age over 55 years old...
February 4, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28160253/physical-frailty-and-sarcopenia-pf-s-a-point-of-view-from-the-industry
#14
Susanna Del Signore, Ronenn Roubenoff
We have observed over the last 15 years a wide debate both in the medical scientific community and in the public health arena on the definition and operationalization of frailty, typically a geriatric condition, and in particular of physical frailty linked to sarcopenia. Because physical frailty in its initial phase can still be reversed, fighting sarcopenia in elderly persons has the potential to slow or halt progressive decline towards disability and dependency. Quite recently, regulators focused attention on frailty as an indicator of biological age to be measured to characterize elderly patients before their inclusion in clinical trials...
February 3, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28153410/effectiveness-of-osteoporosis-self-assessment-tool-for-asians-in-screening-for-osteoporosis-in-healthy-males-over-40-years-old-in-china
#15
Ji-Yuan Huang, Wen-Zhong Song, Mei Huang
In this study, we evaluated the effectiveness of the Osteoporosis Self-assessment Tool for Asians (OSTA) in screening for osteoporosis in the elderly male population in the Chengdu area, China. The Lunar Prodigy Advance bone densitometer was used to measure the bone mineral density of 11,039 healthy males over the age of 40 years. Men with OSTA scores of >-1, -4 < OSTA ≤ -1, or ≤-4 were assigned to the low-risk, moderate-risk, or high-risk group, respectively. The T-scores measured with dual-energy X-ray absorptiometry at the different sites were compared across the groups...
January 30, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28144189/correlation-of-the-lipid-profile-bmi-and-bone-mineral-density-in-postmenopausal-women
#16
Radojka Bijelic, Jagoda Balaban, Snjezana Milicevic
INTRODUCTION: To the reduction of bone density and osteoporosis in postmenopausal women contribute elevated lipid parameters and Body Mass Index (BMI). GOAL: The goal of our study was to determine the correlation between lipid parameters, BMI and osteoporosis in postmenopausal women. MATERIAL AND METHODS: The study was carried out by matched type between experimental group and controls. The experimental group consisted of 100 females at postmenopausal age, in which by the DEXA method was diagnosed osteoporosis at the Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Center of RS during 2015-2016, while the control group consisted of 100 females in a postmenopausal age but without diagnosed osteoporosis...
December 2016: Materia Socio-medica
https://www.readbyqxmd.com/read/28144165/osteosarcopenic-obesity-in-women-impact-prevalence-and-management-challenges
#17
REVIEW
Pegah JafariNasabian, Julia E Inglis, Owen J Kelly, Jasminka Z Ilich
Osteosarcopenic obesity syndrome (OSO) has recently been identified as a condition encompassing osteopenia/osteoporosis, sarcopenia and obesity. OSO is especially deleterious in older adults (even if they are not obese by conventional measures), due to age-related redistribution of fat and its infiltration into bone and muscle. Osteoporosis and bone fractures in elderly increase the risk of sarcopenia, which, through decreased mobility, increases the risk of more falls and fractures, creating a vicious cycle...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28143667/extra-virgin-olive-oil-consumption-reduces-the-risk-of-osteoporotic-fractures-in-the-predimed-trial
#18
J F García-Gavilán, M Bulló, S Canudas, M A Martínez-González, R Estruch, S Giardina, M Fitó, D Corella, E Ros, J Salas-Salvadó
BACKGROUND & AIMS: The incidence of osteoporotic fractures is lower in countries in the Mediterranean basin. Virgin olive oil, a key component of the Mediterranean Diet (MDiet), with recognised beneficial effects on metabolism and cardiovascular health, may decrease the risk of osteoporotic fractures. The aim to this study was to explore the effect of chronic consumption of total olive oil and its varieties on the risk of osteoporosis-related fractures in a middle-aged and elderly Mediterranean population...
January 13, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28139187/cementless-calcar-replacement-stem-with-integrated-greater-trochanter-plate-for-unstable-intertrochanteric-fracture-in-very-elderly-patients
#19
Keizo Wada, Hiroshi Mikami, Koichi Oba, Hiroshi Yonezu, Koichi Sairyo
PURPOSE: To evaluate the clinical results of rigid fixation of the greater trochanter fragment through a consecutive hemiarthroplasty series using a cementless and modular calcar-replacement prosthesis with an integrated plate (MOD-Centaur stem) with 1-year follow-up in very elderly patients with unstable intertrochanteric fractures. METHODS: We assessed 44 consecutive very elderly patients (age >85 years; 2 men, 42 women; mean age at surgery: 89.6 years) with an unstable intertrochanteric fracture who underwent bipolar hemiarthroplasty using the MOD-Centaur stem by the same surgeon...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28125982/an-overview-of-osteoporosis-and-frailty-in-the-elderly
#20
REVIEW
Guowei Li, Lehana Thabane, Alexandra Papaioannou, George Ioannidis, Mitchell A H Levine, Jonathan D Adachi
Osteoporosis and osteoporotic fractures remain significant public health challenges worldwide. Recently the concept of frailty in relation to osteoporosis in the elderly has been increasingly accepted, with emerging studies measuring frailty as a predictor of osteoporotic fractures. In this overview, we reviewed the relationship between frailty and osteoporosis, described the approaches to measuring the grades of frailty, and presented current studies and future research directions investigating osteoporosis and frailty in the elderly...
January 26, 2017: BMC Musculoskeletal Disorders
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