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Osteoporosis elderly

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https://www.readbyqxmd.com/read/28334908/adherence-and-persistence-of-patients-using-oral-bone-sparing-drugs-in-primary-care
#1
Babette C van der Zwaard, Wesley van Hout, Jacqueline G Hugtenburg, Henriëtte E van der Horst, Petra J M Elders
Aim.: Studies based on pharmacy medication records have shown suboptimal adherence and persistence of osteoporosis treatment with oral bone sparing drugs (OBSD). Little is known about adherence and persistence of OBSD treatment in primary care. We assessed adherence and persistence of OBSD use of patients in general practices and identified associated factors. Methods.: Using electronic medical records, adherence and persistence of newly prescribed treatment with OBSD in patients from 16 general practices was retrospectively assessed...
March 8, 2017: Family Practice
https://www.readbyqxmd.com/read/28332125/osteoarthritis-of-the-hip-joint-in-elderly-patients-is-most-commonly-atrophic-with-low-parameters-of-acetabular-dysplasia-and-possible-involvement-of-osteoporosis
#2
Yasuhiro Ishidou, Kanehiro Matsuyama, Daisuke Sakuma, Takao Setoguchi, Satoshi Nagano, Ichiro Kawamura, Shingo Maeda, Setsuro Komiya
As elderly patients with hip osteoarthritis aged, acetabular dysplasia parameters decreased (Sharp's angle, acetabular roof obliquity angle, and acetabular head index) and the incidence of the atrophic type increased. Vertebral body fracture was more frequent in the atrophic type, suggesting the involvement of osteoporosis at the onset of hip osteoarthritis. INTRODUCTION: Osteoarthritis (OA) is associated with increased bone formation at a local site. However, excessive bone resorption has also been found to occur in the early stages of OA...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28331906/associations-between-sarcopenia-and-degenerative-lumbar-scoliosis-in-older-women
#3
Yawara Eguchi, Munetaka Suzuki, Hajime Yamanaka, Hiroshi Tamai, Tatsuya Kobayashi, Sumihisa Orita, Kazuyo Yamauchi, Miyako Suzuki, Kazuhide Inage, Kazuki Fujimoto, Hirohito Kanamoto, Koki Abe, Yasuchika Aoki, Tomoaki Toyone, Tomoyuki Ozawa, Kazuhisa Takahashi, Seiji Ohtori
BACKGROUND: Age-related sarcopenia can cause various forms of physical disabilities. We investigated how sarcopenia affects degenerative lumbar scoliosis (DLS) and lumbar spinal canal stenosis (LSCS). METHODS: Subjects comprised 40 elderly women (mean age 74 years) with spinal disease whose chief complaints were low back pain and lower limb pain. They included 15 cases of DLS (mean 74.8 years) and 25 cases of LSCS (mean age 72.9 years). We performed whole-body dual-energy X-ray absorptiometry (DXA) to analyze body composition, including appendicular and trunk skeletal muscle mass index (SMI; lean mass (kg)/height (m)(2)) and bone mineral density (BMD)...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/28326302/characteristics-of-patients-diagnosed-with-osteoporosis-in-south-korea-results-from-the-national-claim-registry
#4
Hyun Koo Yoon, Young-Kyun Lee, Yong-Chan Ha
BACKGROUND: Although osteoporosis is increasing medical issue in the elderly population, attempts to analyze the characteristics of patients diagnosed with osteoporosis are rare in South Korea. We investigated the characteristics of patients diagnosed with osteoporosis using Korea's National Health Insurance claims data, which includes almost Korean population. METHODS: We evaluated the patients who were diagnosed and treated with osteoporosis in medical institute in South Korea, using the national database by the Health Insurance Review & Assessment Service (HIRA)...
February 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28324215/surgical-treatment-of-osteoporotic-thoraco-lumbar-compressive-fractures-the-use-of-pedicle-screw-with-augmentation-pmma
#5
Massimo Girardo, P Cinnella, G Gargiulo, P Viglierchio, A Rava, S Aleotti
INTRODUCTION: The osteoporosis prevalence in population is age related. The aim of this single-center observational study was evaluate the middle- to long-term performance of cement (PMMA) augmented fenestrated pedicle screws in elderly patients with thoraco-lumbar compressive fractures by osteoporosis. MATERIALS AND METHODS: From 2011 to 2015 we treated 52 patients (20 males and 32 females) suffering from somatic osteoporotic fractures (T10-L2). The average age was 73...
March 21, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28303402/association-between-metabolic-syndrome-and-bone-mineral-density-in-a-taiwanese-elderly-population
#6
Song-Seng Loke, Hsueh-Wen Chang, Wen-Cheng Li
Previous studies have demonstrated uncertainty regarding the effect of metabolic syndrome (MetS) on bone. In the present work, we investigated the association between MetS, its components, and decreased bone mineral density (BMD) in a cross-sectional study of patients who underwent BMD measurement by dual-energy X-ray absorptiometry during a health examination. Decreased BMD was defined as either osteopenia or osteoporosis. MetS components and body mass index (BMI) were compared between individuals with normal and decreased BMD, and simple and multivariate logistic regression analyses were used to evaluate the association between the variables and decreased BMD in women and men...
March 16, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28294983/on-the-emerging-role-of-the-taste-receptor-type-1-t1r-family-of-nutrient-sensors-in-the-musculoskeletal-system
#7
REVIEW
Shoichiro Kokabu, Jonathan W Lowery, Takashi Toyono, Tsuyoshi Sato, Tetsuya Yoda
The special sense of taste guides and guards food intake and is essential for body maintenance. Salty and sour tastes are sensed via ion channels or gated ion channels while G protein-coupled receptors (GPCRs) of the taste receptor type 1 (T1R) family sense sweet and umami tastes and GPCRs of the taste receptor type 2 (T2R) family sense bitter tastes. T1R and T2R receptors share similar downstream signaling pathways that result in the stimulation of phospholipase-C-β2. The T1R family includes three members that form heterodimeric complexes to recognize either amino acids or sweet molecules such as glucose...
March 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28293486/sacral-insufficiency-fractures-recognition-and-treatment-in-patients-with-concurrent-lumbar-vertebral-compression-fractures
#8
Jesse Hatgis, Michelle Granville, Robert E Jacobson, Aldo Berti
INTRODUCTION: In reviewing a larger group of osteoporotic vertebral compression fractures (VCFs), we found that the overall incidence of sacral insufficiency fractures (SIFs) is higher than commonly reported values. This is especially seen in patients with previous or concurrent lumbar VCFs and also in a subgroup that had lumbar stenosis or hip arthroplasty. The altered biomechanics due to associated lumbar stenosis or hip arthroplasty lead to increased mechanical stress on already weakened and deficient sacral alae, which are more vulnerable to osteoporotic weakening than other parts of the sacrum...
February 2, 2017: Curēus
https://www.readbyqxmd.com/read/28291649/cementless-total-hip-arthroplasty-in-octogenarians
#9
Christoph Stihsen, Bernhard Springer, Elena Nemecek, Boris Olischar, Alexandra Kaider, Reinhard Windhager, Bernd Kubista
BACKGROUND: Although several studies indicate excellent results for cementless implants, controversy persists regarding its use in elderly patients. We determined to evaluate the outcome on patients aged over 80 years who were treated with cementless total hip arthroplasty for primary osteoarthritis of the hip. METHODS: We assessed the data of 162 consecutive total hip arthroplasties in octogenarian patients (mean age 83 years, range 80-96 years). A control group was created, consisting of 342 patients aged younger than 80 years (mean age 65 years, range 37-79 years)...
January 26, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28290738/increased-risk-of-intraoperative-and-early-postoperative-periprosthetic-femoral-fracture-with-uncemented-stems
#10
Martin Lindberg-Larsen, Christoffer C Jørgensen, Søren Solgaard, Anne G Kjersgaard, Henrik Kehlet
Background and purpose - The use of uncemented fixation in total hip arthroplasty (THA) is increasing. Registry studies have indicated an increased risk of revision of uncemented implants due to early periprosthetic femoral fracture. In this paper, we describe the incidence and predisposing factors for intraoperative and early postoperative (≤ 90 days) periprosthetic femoral fractures after cemented and uncemented THA. Patients and methods - This was a prospective observational study in 8 Danish high-volume centers from February 2010 to November 2013...
March 14, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28288325/trochanteric-hip-fracture-during-cardioversion-therapy-a-case-report
#11
J Gómez, J Albareda, L Ezquerra
INTRODUCTION: Trochanteric hip fractures in elderly patients with osteoporosis are commonly caused by low energy trauma. The cardioversion therapy is an extremely rare cause of this type of fracture. PRESENTATION OF CASE: We report the case of a woman with hip fracture after cardioversion. DISCUSSION: We discuss the production mechanism of this injury and the importance of the care of the osteoporotic bone under these therapies. CONCLUSION: The propofol sedation should be complemented with skeletal muscle relaxants in the cardioversion therapy to avoid hip fracture in select patients with osteoporosis...
February 27, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28286988/exercise-and-nutritional-approaches-to-prevent-frail-bones-falls-and-fractures-an-update
#12
REVIEW
R M Daly
Osteoporosis (low bone strength) and sarcopenia (low muscle mass, strength and/or impaired function) often co-exist (hence the term 'sarco-osteoporosis') and have similar health consequences with regard to disability, falls, frailty and fractures. Exercise and adequate nutrition, particularly with regard to vitamin D, calcium and protein, are key lifestyle approaches that can simultaneously optimize bone, muscle and functional outcomes in older people, if they are individually tailored and appropriately prescribed in terms of the type and dose...
April 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28275826/lower-jump-power-rather-than-muscle-mass-itself-is-associated-with-vertebral-fracture-in-community-dwelling-elderly-korean-women
#13
Eun Young Lee, Su Jin Lee, Kyoung Min Kim, Da Hea Seo, Seung Won Lee, Han Sol Choi, Hyeon Chang Kim, Yoosik Youm, Chang Oh Kim, Yumie Rhee
Sarcopenia is considered to be a risk factor for osteoporotic fracture, which is a major health problem in elderly women. In this study, we aimed to investigate the association of sarcopenia, with regard to muscle mass and function, with prevalent vertebral fracture in community-dwelling elderly women. We recruited 1281 women aged 64 to 87 years from the Korean Urban Rural Elderly cohort study. Muscle mass and function were measured using bioimpedance analysis and jumping mechanography. Skeletal muscle index (SMI) and jump power were used as an indicator of muscle mass and function, respectively...
March 9, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28258372/fracture-burden-what-two-and-a-half-decades-of-dubbo-osteoporosis-epidemiology-study-data-reveal-about-clinical-outcomes-of-osteoporosis
#14
REVIEW
Jacqueline R Center
PURPOSE OF THE REVIEW: This review aims to highlight important clinical findings from the over 25 year-long Dubbo Osteoporosis Epidemiology Study particularly focusing on outcomes post fracture. RECENT FINDINGS: Every low trauma fracture in the elderly is associated with an increased risk of a subsequent fracture, with a higher risk in men than women. All major or proximal fractures and even minor fractures in the very elderly or minor fractures that are then followed by re-fracture are associated with premature mortality, greatest in the first 5 years post fracture...
March 3, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28256741/osteoporosis-is-the-most-important-risk-factor-for-odontoid-fractures-in-the-elderly
#15
Johannes Kaesmacher, Claudia Schweizer, Alexander Valentinitsch, Thomas Baum, Anna Rienmüller, Bernhard Meyer, Jan S Kirschke, Yu-Mi Ryang
BACKGROUND: Traumatic odontoid fractures (TOFs) have been described as the most common injury affecting the C-spine in the elderly. Previous studies have identified degenerative changes and bone loss as important predisposing factors. However, their interaction and respective age-adjusted impact needs further clarification. METHODS: Retrospective analysis of 5303 patients (≥60 years) admitted to a level-I trauma center between 01/2008-01/2016 who underwent CT imaging of the C-spine...
March 3, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28253944/-management-of-odontoid-fractures-with-compression-screw-and-anterior-transarticular-screw-fixation-in-elderly-patients
#16
J Kočiš, M Kelbl, R Veselý, T Kočiš
PURPOSE OF THE STUDY In the management of dens axis fractures in patients older than 65 years of age the posterior approach is preferred due to osteoporosis and the risk of a failure of anterior osteosynthesis. The posterior approach, however, is associated with a higher incidence of complications. A combination of anterior transarticular fixation of C1/2 (ATS) with compression osteosynthesis of dens axis significantly increases the stability of osteosynthesis. MATERIAL AND METHODS In the period from 2009 to 2015 our hospital admitted 13 patients older than 65 years of age with a diagnosed type III dens axis fracture based on AO classification...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28244906/role-of-weekly-teriparatide-administration-in-osseous-union-enhancement-within-six-months-after-posterior-or-transforaminal-lumbar-interbody-fusion-for-osteoporosis-associated-lumbar-degenerative-disorders-a-multicenter-prospective-randomized-study
#17
RANDOMIZED CONTROLLED TRIAL
Shigeto Ebata, Jun Takahashi, Tomohiko Hasegawa, Keijiro Mukaiyama, Yukihiro Isogai, Tetsuro Ohba, Yosuke Shibata, Toshiyuki Ojima, Zentaro Yamagata, Yukihiro Matsuyama, Hirotaka Haro
BACKGROUND: For elderly patients, posterior lumbar interbody fusion (PLIF) or transforaminal lumbar interbody fusion (TLIF) is usually performed to treat lumbar degenerative diseases. However, some patients exhibit pseudarthrosis following such procedures. The anabolic agent teriparatide is an approved treatment for promoting bone formation in osteoporotic patients. Our multicenter, prospective randomized study assessed the role of once-weekly teriparatide administration on patient outcomes following interbody fusion...
March 1, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28244553/prevalence-of-concomitant-bone-and-muscle-wasting-in-elderly-women-from-the-sarcophage-cohort-preliminary-results
#18
M Locquet, C Beaudart, J-Y Reginster, J Petermans, S Gillain, A Quabron, J Slomian, F Buckinx, O Bruyère
BACKGROUND: Recent studies suggest that bone and muscle wasting are closely interconnected. OBJECTIVE: The aim was of this study is to assess the prevalence of osteoporosis in a population of women diagnosed with sarcopenia. Participants, setting and design: We analyzed cross-sectional data of women, aged 65 years and above, for whom bone mineral density was available at the time of inclusion in the SarcoPhAge (Sarcopenia and Physical impairment with advancing Age) cohort, an ongoing prospective study with the aim to assess consequences of sarcopenia...
2017: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/28243796/monoclonal-gammopathy-of-undetermined-significance-and-bone-health-outcomes-a-systematic-review-and-exploratory-meta-analysis
#19
Nicola Veronese, Claudio Luchini, Marco Solmi, Giuseppe Sergi, Enzo Manzato, Brendon Stubbs
Monoclonal gammopathy of undetermined significance (MGUS) is a common condition in the elderly. A number of studies have investigated the relationship between MGUS and bone health outcomes including bone mineral density (BMD), osteoporosis and fractures, but no meta-analysis exists. We conducted a systematic review and exploratory meta-analysis comparing bone health outcomes in patients with MGUS. Two independent authors searched PubMed and Scopus from inception until 19 October 2016. A meta-analysis of cross-sectional and longitudinal studies investigating fractures and BMD was conducted...
February 27, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28229037/long-term-effects-of-a-ten-year-osteoporosis-intervention-program-in-a-swedish-population-a-cross-sectional-study
#20
Ann-Charlotte Grahn Kronhed, Helena Salminen
The aim of the study was to explore long-term effects seven years after the completion of a ten-year community-based osteoporosis intervention program in Vadstena, Sweden. The association between calcaneal bone mineral density and several life style factors, and the impact of risk factors for sustaining a fracture after the age of 50 were also studied. Previous participants in the intervention group, and matched subjects were invited to calcaneal bone mass measurement by a portable device including the dual X-ray and laser (DXL) technology by Calscan, and to complete a questionnaire in 2006...
March 2017: Preventive Medicine Reports
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