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Osteoporosis elderly

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https://www.readbyqxmd.com/read/27909782/associations-between-serum-vitamin-e-concentration-and-bone-mineral-density-in-the-us-elderly-population
#1
J Zhang, X Hu, J Zhang
: Mixed findings regarding effects of vitamin E on bone metabolism existed. We were the first to find a negative association between serum α-tocopherol concentration and bone mineral density in the US elderly population. Using vitamin E supplement as α-tocopherol to promote bone health was not warranted at this time. INTRODUCTION: The aim of the study is to examine the associations between serum vitamin E (α-tocopherol and γ-tocopherol) status and bone mineral density (BMD) among the US elderly population...
December 1, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27908253/assessment-of-bone-quality-in-osteoporosis-treatment-with-bone-anabolic-agents-really-something-new
#2
Fabio Massimo Ulivieri, Renata Caudarella, Marzia Camisasca, Daniela Maria Cabrini, Ilaria Merli, Carmelo Messina, Luca Petruccio Piodi
Osteoporosis is a chronic pathologic condition, particularly of the elderly, in which a reduction of bone mineral density (BMD) weakens bone, leading to the so-called fragility fractures, most often of spine and femur. The gold standard exam for the quantitative measurement of BMD is the dual X-ray photon absorptiometry (DXA), a radiological method. However, a relevant number of fragility fractures occurs in the range of normal BMD values, meaning that also qualitative aspects of bone play a role, namely bone architecture and bone geometry...
December 1, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27904420/role-of-the-whole-body-vibration-machine-in-the-prevention-and-management-of-osteoporosis-in-old-age-a-systematic-review
#3
REVIEW
Myint Swe, Biju Benjamin, Aye Aye Tun, Sandheep Sugathan
A literature search of related articles was carried out in electronic data sources. Initially, 276 randomised controlled trials related to the title were collected, after which 44 were selected using the keywords. Overlapping articles, articles with a study duration of less than six months, and studies involving young participants were removed from the list. The remaining 20 articles were checked for entitlement using the PEDro scale. A total of nine eligible articles with 1486 participants were analysed. Seven trials used dual-energy x-ray absorptiometry (DXA) to measure bone mineral density (BMD)...
September 2016: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/27900428/relationship-between-baseline-characteristics-and-response-to-risedronate-treatment-for-osteoporosis-data-from-three-japanese-phase-iii-trials
#4
T Mawatari, R Muraoka, Y Iwamoto
: We evaluated the influence of baseline age, bone mineral density (BMD), and serum levels of vitamin D on the response to risedronate treatment. Risedronate consistently increased BMD, but our results suggest vitamin D supplementation may be necessary to achieve optimal treatment effect. Furthermore, early intervention may help prevent bone fractures. INTRODUCTION: We aimed to investigate the influence of baseline age, BMD, and vitamin D insufficiency on the response to risedronate treatment...
November 30, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27896870/tetracyclines-and-or-nicotinamide-in-blistering-dermatoses
#5
Ayman Abdelmaksoud
I read with interest a report by von Köckritz et al(1) . Tetracycline therapy, particularly in autoimmune blistering conditions, has become an acceptable treatment modality among elderly individuals, particularly those with osteoporosis, DM, and hypertension. This drug has also been given in combination with immunosuppressive treatment for more rapid tapering of the latter(2) .Minocycline besides having antimicrobial activity, it possesses anti-inflammatory and anti-apoptotic properties and causes inhibition of proteolysis, angiogenesis, and collagenase, and ability to induce read-through of premature stop mutations(3) ...
November 29, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27895472/safety-and-effectiveness-of-daily-teriparatide-for-osteoporosis-in-patients-with-severe-stages-of-chronic-kidney-disease-post-hoc-analysis-of-a-postmarketing-observational-study
#6
Atsushi Nishikawa, Fumito Yoshiki, Masanori Taketsuna, Kenta Kajimoto, Hiroyuki Enomoto
Teriparatide (recombinant 1-34 N-terminal sequence of human parathyroid hormone) for the treatment of osteoporosis should be prescribed with caution in patients with severe stages of chronic kidney disease (CKD). However, in clinical settings, physicians and surgeons who treat such patients have few available options. We sought to further explore the safety and effectiveness of teriparatide for the treatment of osteoporosis in Japanese patients with severe stages of CKD. This was a post hoc analysis of a postmarketing surveillance study that included patients with osteoporosis at high risk of fracture and stage 4 or 5 CKD...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27889054/tocotrienols-health-and-ageing-a-systematic-review
#7
REVIEW
Ekavi N Georgousopoulou, Demosthenes B Panagiotakos, Duane D Mellor, Nenad Naumovski
OBJECTIVES: A systematic review of studies was undertaken to evaluate the potential effect of intake of tocotrienols or circulating levels of tocotrienols on parameters associated with successful ageing, specifically in relation to cognitive function, osteoporosis and DNA damage. METHODS: Following PRISMA guidelines a systematic review of epidemiological observational studies and clinical trials was undertaken. Inclusion criteria included all English language publications in the databases PubMed and Scopus, through to the end of July 2016...
January 2017: Maturitas
https://www.readbyqxmd.com/read/27889047/sex-differences-in-the-association-between-stroke-and-bone-mineral-density-in-elderly-koreans-the-korean-national-health-and-nutrition-examination-survey-2008-2010
#8
Ji Eun Lee, Hye-Rim Jeon, Jung Keun Park, Kyung-Do Han, Ji-Hyun Kim, Jinnie Yoon, Seok-Won Park, Yang-Hyun Kim, Kyung-Hwan Cho
OBJECTIVES: The aim of this study was to investigate whether osteoporosis is more prevalent in elderly Korean people who have had a stroke and whether the association differs by sex. STUDY DESIGN: A total of 3806 elderly subjects (1951 men and 1855 women) from the Korea National Health and Nutrition Examination Survey were included in this study. Stroke history was determined by self-administered questionnaire. Bone mineral density (BMD) was measured at the lumbar spine, total hip, and neck of the femur using dual-energy X-ray absorptiometry...
January 2017: Maturitas
https://www.readbyqxmd.com/read/27886696/a-review-of-osteoporosis-in-the-older-adult
#9
REVIEW
Paloma Alejandro, Florina Constantinescu
Osteoporosis in the elderly population is common. It results in more than 1.5 million fractures per year in the United States. The goal of managing osteoporosis is to prevent fractures. In men, osteoporosis is underrecognized and undertreated. More men than women die every year as a consequence of hip fractures. A review of diagnosis and treatment of osteoporosis is described in this article. Bisphosphonates are the first-line treatment for men and women. In the past several years, advances in bone biology have resulted in major therapeutic advances...
February 2017: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/27874933/vitamin-d-supplementation-for-osteoporosis-in-older-adults-can-we-make-it-help-better
#10
C-H Dong, Q-M Gao, Z-M Wang, A-M Wang, P Zhen
With the increase of the average age of our population, the incidence of diseases specific for older adults has been increasing. One of such diseases is osteoporosis. The true incidence of osteoporosis is unknown. But the estimates indicate that this disease affects wide proportions of the population, ranging in millions or even ten millions in large countries like the United States. As this poses a significant burden on the health care system, interventions that could prevent or treat this condition are in the focus of clinical research...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27866217/osteonecrosis-of-the-jaw-onj-and-atypical-femoral-fracture-aff-in-an-osteoporotic-patient-chronically-treated-with-bisphosphonates
#11
A Sánchez, R Blanco
The aim of the study is to report the rare association of two complications of long-term treatment of osteoporosis with bisphosphonates in the same Caucasian elderly patient. A female patient of Italian descent, age 87 years, consulted in February 2013. She had a history of osteoporosis and had taken alendronate weekly for 7 years (1999-2006). Due to low back pain, an orthopedist had indicated i.v. zoledronic acid, 5 mg/year for 3 years (2006-2008). She received occasional supplements of ergocalciferol...
November 20, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27858878/association-between-pulmonary-fibrosis-and-osteoporosis-in-the-elderly-people-a-case-control-study
#12
Zhong Xie, Yanhong He, Yongqiang Sun, Zhanzhan Lin, Mingzhi Yang, Qian Liu, Sihai Liu
In this case-control study, we evaluated the association between osteoporosis and pulmonary fibrosis in the elderly. Participants were divided into a test group and a control group depending on bone mineral density and grid pattern changes of pulmonary fibrosis. We measured general conditions, related risk factors, serum biochemical index, grid pattern changes of double lungs, pulmonary function, arterial oxygen pressure (PO2), and bone mineral density of participates, and investigated the data through statistical analysis on SPSS 17...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27856519/transcriptional-landscape-analysis-identifies-differently-expressed-genes-involved-in-follicle-stimulating-hormone-induced-postmenopausal-osteoporosis
#13
Katre Maasalu, Ott Laius, Lidiia Zhytnik, Sulev Kõks, Ele Prans, Ene Reimann, Aare Märtson
Osteoporosis is a disorder associated with bone tissue reorganization, bone mass, and mineral density. Osteoporosis can severely affect postmenopausal women, causing bone fragility and osteoporotic fractures. The aim of the current study was to compare blood mRNA profiles of postmenopausal women with and without osteoporosis, with the aim of finding different gene expressions and thus targets for future osteoporosis biomarker studies. Our study consisted of transcriptome analysis of whole blood serum from 12 elderly female osteoporotic patients and 12 non-osteoporotic elderly female controls...
November 17, 2016: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27845703/older-swedish-adults-with-high-self-perceived-health-show-optimal-25-hydroxyvitamin-d-levels-whereas-vitamin-d-status-is-low-in-patients-with-high-disease-burden
#14
Martin Carlsson, Pär Wanby, Lars Brudin, Erik Lexne, Karin Mathold, Rebecca Nobin, Lisa Ericson, Ola Nordqvist, Göran Petersson
Controversy pervades the definition of adequate and optimal vitamin D status. The Institutes of Medicine have recommended serum 25(OH)D levels above 50 nmol/L based upon evidence related to bone health, but some experts, including the Endocrine Society and International Osteoporosis Foundation, suggest a minimum serum 25(OH)D level of 75 nmol/L to reduce the risk of falls and fractures in older adults. In a cross-sectional study, we compared vitamin D status in people ≥75 years selected from four groups with a frailty phenotype, combined with a control group free from serious illness, and who considered themselves completely healthy...
November 11, 2016: Nutrients
https://www.readbyqxmd.com/read/27830871/assessment-of-femoral-neck-fractures-in-the-elderly-with-respect-to-morphology-and-mineral-density
#15
Hülya Çetin Sorkun, Arzu Hanım Yay, Esra Balcıoğlu, Saim Özdamar
BACKGROUND: Femoral neck fractures are among the major orthopedic problems seen in the elderly and the annual mortality rate is high. The Ca/P ratio can be used as an indicator of osteoporosis. The purpose of this study is to investigate the microarchitectural structure of the fractured regions of femoral head as well as bone mineral density in female and male patients. MATERIALS AND METHODS: The bone tissues taken from the fractured regions of 10 male and 9 female patients were examined with a scanning electron microscope...
November 10, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27822030/management-of-copd-equal-treatment-across-age-gender-and-social-situation-a-register-study
#16
Ingela Henoch, Susann Strang, Claes-Göran Löfdahl, Ann Ekberg-Jansson
Chronic obstructive pulmonary disease (COPD) is a progressive chronic disease where treatment decisions should be based on disease severity and also should be equally distributed across age, gender, and social situation. The aim of this study was to determine to what extent patients with COPD are offered evidence-based interventions and how the interventions are distributed across demographic and clinical factors in the sample. Baseline registrations of demographic, disease-related, and management-related variables of 7,810 patients in the Swedish National Airway Register are presented...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27807202/estrogens-and-androgens-in-skeletal-physiology-and-pathophysiology
#17
REVIEW
Maria Almeida, Michaël R Laurent, Vanessa Dubois, Frank Claessens, Charles A O'Brien, Roger Bouillon, Dirk Vanderschueren, Stavros C Manolagas
Estrogens and androgens influence the growth and maintenance of the mammalian skeleton and are responsible for its sexual dimorphism. Estrogen deficiency at menopause or loss of both estrogens and androgens in elderly men contribute to the development of osteoporosis, one of the most common and impactful metabolic diseases of old age. In the last 20 years, basic and clinical research advances, genetic insights from humans and rodents, and newer imaging technologies have changed considerably the landscape of our understanding of bone biology as well as the relationship between sex steroids and the physiology and pathophysiology of bone metabolism...
January 2017: Physiological Reviews
https://www.readbyqxmd.com/read/27805313/the-effect-of-inhaled-corticosteroids-on-bone-mineral-density-measured-by-quantitative-ultrasonography-in-an-older-population
#18
Ghulam Sarwar, Alessandra Bisquera, Roseanne Peel, Stephen Hancock, Christopher Grainge, John Attia
INTRODUCTION: Prolonged use of systemic corticosteroids leads to reduced bone mineral density and osteoporosis, in turn increasing the risk of minimal trauma fractures with their associated morbidity and mortality in elderly populations. However, the effect of inhaled corticosteroids on bone mineral density has been debated in the medical literature. OBJECTIVES: We aimed to determine the effect of inhaled corticosteroids on bone mineral density measured using calcaneal quantitative ultrasonography in a cohort of older Australians...
November 2, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27803626/body-fat-and-physical-activity-modulate-the-association-between-sarcopenia-and-osteoporosis-in-elderly-korean-women
#19
Inhwan Lee, Jinkyung Cho, Youngyun Jin, Changduk Ha, Taehee Kim, Hyunsik Kang
This study examined whether modifiable lifestyle factors, such as body fatness and physical activity, modulate the association between sarcopenia and osteoporosis. In a cross-sectional design, 269 postmenopausal women, aged 65 years and older, underwent dual-energy X-ray absorptiometry (DEXA) scans to measure their body fat percentage, total fat mass, total fat-free mass, appendicular lean mass, bone mineral density (BMD) and bone mineral content. The participants wore a uniaxial accelerometer for seven consecutive days to quantify daily physical activity...
September 2016: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/27799687/comparison-of-bone-density-on-the-dominant-and-nondominant-sides-between-healthy-elderly-individuals-and-stroke-patients
#20
Dong Gi Min, Jae Hong Lee, Han Seong Choe, Eun Jung Kim, So Hong Shin, Jin Hwan Lee
[Purpose] This study evaluated differences between healthy elderly individuals and stroke patients by comparing their dominant and nondominant sides. [Subjects and Methods] Thirty-five elderly individuals participated in this study and divided into a stroke group and a control group. The outcome measures were general characteristics and bone mineral density. Bone mineral density was evaluated by using the osteoporosis index. OsteoPro, T score, and Z score were used for the calcaneus region of the dominant side, and OsteoPro was used for that of the nondominant side...
September 2016: Journal of Physical Therapy Science
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