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Osteoporosis prevention

Antonio Nardone, Elena Paola Ferrari
OBJECTIVES: Chronic diseases are a major problem, whose importance is nowadays raising up. Up to 86% of deaths are directly related to chronic diseases in Europe as they represent large amount of total diseases, with a major impact on global health spending. METHODS: Patients suffering from heterogeneous disabilities (such as Parkinson's disease, stroke, multiple sclerosis, osteoporosis, osteoarthritis) often show an interaction between the main disease and comorbidity and multimorbidity...
February 2018: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
Michele Vitacca, Dina Visca, Antonio Spanevello
OBJECTIVES: Chronic Obstructive Pulmonary Disease (COPD) is a common, preventable and treatable disease that is characterized by persistent respiratory symptoms and airflow limitation. Cardiovascular diseases, osteoporosis, depression/anxiety, musculoskeletal impairment and obstructive sleep apnea are frequent and important comorbidities in COPD, often under-diagnosed, and associated with poor health status and prognosis. METHODS: Pulmonary rehabilitation improves symptoms, quality of life, pulmonary function, and health care in patients with chronic respiratory disease...
February 2018: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
Yuzaburo Inoue, Kanako Mitsunaga, Takeshi Yamamoto, Koki Chiba, Fumiya Yamaide, Taiji Nakano, Yoshinori Morita, Akiko Yamaide, Shuichi Suzuki, Takayasu Arima, Ken-Ichi Yamaguchi, Minako Tomiita, Naoki Shimojo, Yoichi Kohno
BACKGROUND: Bisphosphonates are recommended for use as first-line therapy for the prevention and treatment of glucocorticoid-induced osteoporosis in adults. However, the appropriate usage of bisphosphonates for the prevention or treatment of glucocorticoid-induced osteoporosis in children remains unclear. METHODS: We performed a cross-sectional study to clarify the factors associated with the development of glucocorticoid-induced bone loss and osteoporosis in patients with childhood-onset rheumatic disease and to investigate the impact of the early use of alendronate...
June 18, 2018: Pediatric Rheumatology Online Journal
Kwang-Jin Kim, Yongjin Lee, Hae-Gwang Hwang, Sang Hyun Sung, Mina Lee, Young-Jin Son
Osteoporosis is a disease characterized by osteoclast-mediated low bone mass. The modulation of osteoclasts is important for the prevention or therapeutic treatment of loss of bone mass. Osteoclasts, which are bone-resorbing multinucleated cells, are differentiated from the hematopoietic stem cell monocyte/macrophage lineage by Receptor activator of nuclear factor kappa-B ligand (RANKL) expressed from osteoblasts and stromal cells. RANKL signaling ultimately activates nuclear factor of activated T Cells 1 (NFATc1), which is a master transcription factor in osteoclastogenesis...
June 15, 2018: Journal of Clinical Medicine
Antonella Delle Fave, Marta Bassi, Elena S Boccaletti, Carlotta Roncaglione, Giuseppina Bernardelli, Daniela Mari
In the last few decades, the relationship between physical conditions and mental health has increasingly attracted the interest of researchers and professionals across disciplines. This relationship is especially relevant in old age, as the challenges posed by aging at various levels represent crucial concerns for policy makers. Due to the remarkable increase in life expectancy across countries, sustainable prevention strategies are needed to help individuals preserve psychophysical well-being in old age. In particular, the regular practice of a moderately intense physical activity is recommended by the World Health Organization to enhance balance, prevent falls, strengthen muscles, and promote psychophysical well-being...
2018: Frontiers in Psychology
Yu-Qiong He, Hua Yang, Yi Shen, Jian-Hua Zhang, Zhi-Guo Zhang, Lin-Lin Liu, Hong-Tao Song, Bin Lin, Hsien-Yeh Hsu, Lu-Ping Qin, Ting Han, Hai-Liang Xin, Qiao-Yan Zhang
Estrogen deficiency and inflammation are known to play important roles in bone metabolism and occurrence of osteoporosis. Monotropein as an iridoid glycoside is reported to decrease estrogen deficiency-induced bone loss and inhibit inflammatory response in LPS-induced RAW 264.7 macrophages. However, the effect of monotropein on bone loss in chronic inflammatory conditions remains unclear. It was found in the present study that monotropein significantly inhibited bone mass reduction and improved bone micro-architectures by enhancing bone formation and blocking increased secretion of inflammatory cytokines in osteoporotic mice induced by combined ovariectomy and LPS...
June 14, 2018: Chemico-biological Interactions
Jyotirmaya Behera, Akash K George, Michael J Voor, Suresh C Tyagi, Neetu Tyagi
Hydrogen sulfide (H2 S) is a novel gasotransmitter produced endogenously in mammalian cells, which works by mediating diverse physiological functions. An imbalance in H2 S metabolism is associated with defective bone homeostasis. However, it is unknown whether H2 S plays any epigenetic role in bone loss induced by hyperhomocysteinemia (HHcy). We demonstrate that diet-induced HHcy, a mouse model of metabolite induced osteoporosis, alters homocysteine metabolism by decreasing plasma levels of H2 S. Treatment with NaHS (H2 S donor), normalizes the plasma level of H2 S and further alleviates HHcy induced trabecular bone loss and mechanical strength...
June 13, 2018: Bone
Shin-Ya Tamechika, Kaneshige Sasaki, Yoshihito Hayami, Shin-Ichiro Ohmura, Shinji Maeda, Shiho Iwagaitsu, Taio Naniwa
The randomized, clinical trial demonstrated that switching to monthly minodronate from weekly alendronate and risedronate provides greater increases in patients' satisfaction and bone mineral density and more substantial decreases in a bone resorption marker than continuing weekly alendronate and risedronate in patients with systemic rheumatic diseases on glucocorticoid therapy. PURPOSE: Osteoporosis and associated fractures are major concerns for patients with systemic rheumatic diseases on long-term glucocorticoid therapy...
June 13, 2018: Archives of Osteoporosis
L S Demidko, V I Rudenko, V A Grigoryan, Yu L Demidko, M E Enikeev, Zh Sh Inoyatov, M V Amosova
RELEVANCE: The prevalence of urolithiasis and osteoporosis (OP) indicates that these diseases may be found concurrently in the same patient. The detection of risk factors for OP and disorders of calcium metabolism in patients with urolithiasis is of interest in the context of primary stone formation and metaphylaxis. AIM: To identify risk factors for osteoporosis and disorders of calcium metabolism in patients with urolithiasis. MATERIALS AND METHODS: Osteoporosis risk factors were studied in 45 urolithiasis patients undergoing surgical treatment...
May 2018: Urologii︠a︡
Junkichi Kanda, Nobuo Izumo, Megumi Furukawa, Taketoshi Shimakura, Noriaki Yamamoto, Hideaki E Takahashi, Toshinari Asakura, Hiroyuki Wakabayashi
Immunosuppressive therapy is considered as one of the factors inducing to the onset of osteoporosis after organ transplantation. Chronic immunosuppressive therapy after transplantation is required for organ transplant patients, and it is important to prevent the occurrence of osteoporotic fractures to maintain the quality of life in patients. In this study, we examined the effects of cyclosporine and tacrolimus on bone metabolism in rats. Five-week-old male Wistar rats were treated orally with 15 mg/kg cyclosporine or 1...
2018: Biomedical Research
Donald Duerksen, Maria Ines Pinto-Sanchez, Alexandra Anca, Joyce Schnetzler, Shelley Case, Jenni Zelin, Adrianna Smallwood, Justine Turner, Elena Verdú, J Decker Butzner, Mohsin Rashid
OBJECTIVE: To describe clinical issues related to bone health in patients with celiac disease (CD) and to provide guidance on monitoring bone health in these patients. SOURCES OF INFORMATION: A PubMed search was conducted to review literature relevant to CD and bone health, including guidelines published by professional gastroenterological organizations. MAIN MESSAGE: Bone health can be negatively affected in both adults and children with CD owing to the inflammatory process and malabsorption of calcium and vitamin D...
June 2018: Canadian Family Physician Médecin de Famille Canadien
Rongyao Xu, Xiang Shen, Yameng Si, Yu Fu, Weiwen Zhu, Tao Xiao, Zongyun Fu, Ping Zhang, Jie Cheng, Hongbing Jiang
The alteration of age-related molecules in the bone marrow microenvironment is one of the driving forces in osteoporosis. These molecules inhibit bone formation and promote bone resorption by regulating osteoblastic and osteoclastic activity, contributing to age-related bone loss. Here, we observed that the level of microRNA-31a-5p (miR-31a-5p) was significantly increased in bone marrow stromal cells (BMSCs) from aged rats, and these BMSCs demonstrated increased adipogenesis and aging phenotypes as well as decreased osteogenesis and stemness...
June 12, 2018: Aging Cell
Polly Ryan, Paula Papanek, Mary Ellen Csuka, Melissa E Brown, Sarah Hopkins, Shelly Lynch, Victoria Scheer, Andrea Schlidt, Ke Yan, Pippa Simpson, Ray Hoffman
BACKGROUND: Osteoporosis is a prevalent and debilitating condition affecting >50% of post-menopausal women. Yet, a low percentage of women regularly engage in health promoting behaviors associated with osteoporosis prevention. Complex, multidimensional, m-Health interventions hold promise to effect engagement in health behavior change related to calcium and vitamin D intake, balance, core and leg strength, and physical activity. METHODS: Striving to be Strong study (R01NR013913-01) tests the efficacy of a research and theory based, patient centered, dynamically tailored intervention delivered via smart phone apps...
June 9, 2018: Contemporary Clinical Trials
Jin-Peng He, Xiu Feng, Ju-Fang Wang, Wen-Gui Shi, He Li, Sergei Danilchenko, Aleksei Kalinkevich, Mykhailo Zhovner
Bone loss induced by microgravity is a substantial barrier to humans in long-term spaceflight. Recent studies have revealed that icariin (ICA) can attenuate osteoporosis in postmenopausal women and ovariectomized rats. However, whether ICA can protect against microgravity-induced bone loss remains unknown. In this study, the effects of ICA on a hindlimb suspension rodent model were investigated. Two-month-old female Wistar rats were hindlimb suspended and treated with ICA (25 mg·kg-1 ·d-1 , i.g.) or a vehicle for 4 weeks (n = 6)...
June 11, 2018: Acta Pharmacologica Sinica
Li Cheng, Shengyuan Zhou, Yin Zhao, Yanqing Sun, Zheng Xu, Bo Yuan, Xiongsheng Chen
Osteoporosis is a common disease associated with age and menopausal status. Postmenopausal osteoporosis is the most common type of primary osteoporosis and is accompanied by increased risk of osteoporotic fracture. Natural and herbal compounds have long been used to prevent and treat many human diseases. Here, we demonstrated that tanshinone IIA prevented ovariectomy-induced bone loss in an in vivo mouse model that closely mimics osteoporosis. In addition, we found that tanshinone IIA inhibited the receptor activator of nuclear factor NF-κB ligand (RANKL)-induced osteoclast differentiation and osteoclastogenesis in vitro ...
2018: American Journal of Translational Research
Katerina Trajanoska, Josje D Schoufour, Ester A L de Jonge, Brenda C T Kieboom, Marlies Mulder, Bruno H Stricker, Trudy Voortman, Andre G Uitterlinden, Edwin H G Oei, M Arfan Ikram, M Carola Zillikens, Fernando Rivadeneira, Ling Oei
Fracture incidence needs to be evaluated over time to assess the impact of the enlarging population burden of fractures (due to increase in lifespan) and the efficacy of fracture prevention strategies. Therefore, we aimed to evaluate the association of femoral neck bone mineral density (FN-BMD) measured using dual-energy X-ray absorptiometry (DXA) at baseline with fracture risk over a long follow-up time period. Incident non-vertebral fractures were assessed in 14,613 individuals participating in the Rotterdam Study with up to 20 years of follow-up...
June 7, 2018: Bone
Jie Liang, Wei-Dong Meng, Jun-Ming Yang, Sheng-Long Li, Mi-Na Zhong, Xuan-Xuan Hou, Ran Wang, Yu-Ying Long, Liang-Xiao Bao, Ming Bao
OBJECTIVE: Liver cirrhosis (LC) was associated with an increased risk of osteoporosis; however, the association between LC and fracture risk was inconclusive. Therefore, this systematic review and meta-analysis aims to explore the association between LC and fracture risk. DESIGN: To identify related literature, a systematic search of PubMed, EMBASE, Web of science, and the Cochrane Library from 1965 to July 2017 without language limitation was performed. The random effects model described by DerSimonian and Laird was used to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs)...
June 9, 2018: Clinical Endocrinology
Xiaoyan Luo, Ran Cheng, Jing Zhang, Yaxian Ma, Jun Zhang, Yunyao Luo, Liangzhi Xu
The study aims to investigate the body composition and bone mineral density (BMD) characteristics and discuss the relationships among body composition, BMD and sex steroid level in POF. A total of 240 POF patients, 240 normal women, and peri/postmenopausal women (Peri-M/Post-M) (260 patients in each group) were included. Compared to the control group, POF patients? strength of left/right lower limb (SLL/SRL), muscle distributing coefficient of lower limbs (MD) decreased however, waist circumference (WC) and hip circumference (HC) increased...
June 8, 2018: Gynecological Endocrinology
H Dreyer, J Grischke, C Tiede, J Eberhard, A Schweitzer, S E Toikkanen, S Glöckner, G Krause, M Stiesch
OBJECTIVE: The purpose of this systematic review and meta-analysis was to assess the prevalence, incidence and risk factors of peri-implantitis in the current literature. MATERIAL AND METHODS: An electronic search was performed to identify publications from January 1980 until March 2016 on 9 databases. The prevalence and incidence of peri-implantitis were assessed in different subgroups of patients and the prevalences were adjusted for sample size (SSA) of studies...
June 7, 2018: Journal of Periodontal Research
Snezana Tomasevic-Todorovic, Atina Vazic, Abukari Issaka, Fahad Hanna
Background: Both osteoporosis and osteopenia remain worldwide public health concerns. They both lead to bone fractures, which can lead to disability and burden on those who are afflicted. Objectives: To assess and compare fracture risk between these two groups of patients. Patients and methods: Our cross-sectional study included 82 patients (46 with osteoporosis and 36 with osteopenia) with an average age of 63±9.33 years, who received treatment at the Clinic for Medical Rehabilitation, Clinical Center of Vojvodina in Novi Sad, Serbia...
2018: Open Access Rheumatology: Research and Reviews
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