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Osteoporosis prevention

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https://www.readbyqxmd.com/read/29027045/characteristics-of-patients-with-fragility-hip-fractures-in-the-northern-kyushu-district-in-japan-a-multicenter-prospective-registry-based-on-an-electronic-data-capture-system
#1
Akiko Oyamada, Yoshihiro Matsumoto, Yoshifumi Wakata, Atsushi Kimura, Ko Ikuta, Kuniyoshi Tsuchiya, Naohisa Tayama, Shinji Tomari, Hisaaki Miyahara, Takao Mae, Hirokazu Shiraishi, Taichi Saito, Takeshi Arizono, Kozo Kaji, Taro Mawatari, Masami Fujiwara, Riku Sakimura, Kunichika Shin, Kenichi Ninomiya, Kazutoshi Nakaie, Yasuaki Antoku, Shoji Tokunaga, Naoki Nakashima, Yukihide Iwamoto, Yasuharu Nakashima
Osteoporosis has become a worldwide public health problem, in part due to the fact that it increases the risk of fragility hip fractures (FHFs). The epidemiological assessment of FHFs is critical for their prevention; however, datasets for FHFs in Japan remain scarce. This was a multicenter, prospective, observational study in the northern district of Kyushu Island. Inclusion criteria were age > 60 years with a diagnosis of FHF and acquisition of clinical data by an electronic data capture system. Of 1294 registered patients, 1146 enrolled in the study...
October 12, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29027021/bortezomib-prevents-ovariectomy-induced-osteoporosis-in-mice-by-inhibiting-osteoclast-differentiation
#2
Sung-Hyun Kim, Myoung Ok Kim, Hyo Jeong Kim, Sanjiv Neupane, Hyung Joon Kim, Ji Hye Lee, Hong-Hee Kim, Jae-Young Kim, Youngkyun Lee
Bone homeostasis is achieved through coordinated activities of bone-forming osteoblasts and bone-resorbing osteoclasts. When the balance is skewed in favor of osteoclasts due to hormonal or inflammatory issues, pathologic bone loss occurs leading to conditions such as osteoporosis, rheumatoid arthritis, and periodontitis. Bortezomib is the first in-class of proteasome inhibitors used as an anti-myeloma agent. In the present study, we show that bortezomib directly inhibited the receptor activator of nuclear factor κB ligand (RANKL)-dependent osteoclast differentiation of mouse bone marrow macrophages...
October 12, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29024399/high-magnesium-prevents-matrix-vesicle-mediated-mineralization-in-human-bone-marrow-derived-mesenchymal-stem-cells-via-mitochondrial-pathway-and-autophagy
#3
Yaqiang Li, Jing Wang, Jiaji Yue, Yu Wang, Chunxi Yang, Quanjun Cui
Magnesium, as a physiological calcium antagonist, plays vital role in the bone metabolism and the balance between magnesium and calcium is crucial in bone physiology. We recently demonstrated that matrix mineralization in human bone marrow-derived mesenchymal stem cells (hBMSCs) can be suppressed by high Mg(2+) . However, a complete understanding of the mechanisms involved still remains to be elucidated. As mitochondrial calcium phosphate granules depletion manifests concurrently with the appearance of matrix vesicles (MVs) and autophagy are associated with matrix mineralization, we studied the effect of high extracellular Mg(2+) on these pathways...
October 10, 2017: Cell Biology International
https://www.readbyqxmd.com/read/29021477/management-of-osteoporosis-in-chronic-kidney-disease
#4
Kosaku Nitta, Aiji Yajima, Ken Tsuchiya
Chronic kidney disease (CKD) patients with coexisting osteoporosis are becoming common. Many of the therapeutic agents used to treat osteoporosis are known to be affected by the renal function. It is generally thought that osteoporosis in G1 to G3 CKD patients can be treated as in non-CKD patients with osteoporosis. In stage 4 or more advanced CKD patients and CKD patients on dialysis with osteoporosis, however, bisphosphonates must be used with caution, bearing in mind the potential development of such disorders as adynamic bone disease...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29021211/pfmg1-promotes-osteoblast-differentiation-and-prevents-osteoporotic-bone-loss
#5
Liyuan Li, Pan Wang, Kaiqiang Hu, Xiaoyan Wang, Wenping Cai, Chao Ai, Shangfeng Liu, Zhao Wang
Nacre is a widely used mineral medicine that has been reported to have beneficial effects in bone remodeling without an increase in inflammation. Water-soluble nacre matrix has been demonstrated to be responsible for the effect, yet core active ingredients are unknown. Pinctada fucata mantle gene 1 (PFMG1) was first discovered in the mantle tissue of Pinctada fucata. The protein has 2 EF-hands, a calcium-binding domain. PFMG1 protein can affect the growth of calcium carbonate crystals in vitro Here, we demonstrate that PFMG1 affects cell-cycle distribution and promotes preosteoblast proliferation...
October 11, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28994329/the-value-of-self-medication-summary-of-existing-evidence
#6
Joshua Noone, Christopher M Blanchette
AIM: The aim of this review was to identify the international evidence that is currently available on the economic value of self-care through responsible self-medication, in terms of the measures related to access to treatment, time, and productivity. METHODS: A targeted literature search was conducted for 1990-2016, including data gathered from members of the World Self-Medication Industry and searches on PubMed, EBSCOHost, and Google Scholar. Specific searches of individual drug classes known to be switched to nonprescription status in this period were also conducted...
October 10, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28990503/risk-assessment-of-isolated-isoflavones-intake-on-human-health
#7
Antonella Smeriglio, Antonella Calderaro, Marcella Denaro, Giuseppina Laganà, Ersilia Bellocco
Isoflavones are naturally occurring flavonoids characterized by a structure able to exert non-steroidal estrogen-like activity on human cells. The atypical linkage between the rings B and C remarkable influences these potentialities and confers them specific applications, along with the biochemical modification such as acetylation and malonylation. Plants belonging to Leguminosae family are the most abundant and rich sources for human organism, where, after their ingestion and metabolization, they show positive health effects on several diseases, especially in the prevention of coronary heart and neurological diseases, hormone-related cancers, osteoporosis, and postmenopausal symptoms...
October 6, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28983908/interventions-for-managing-medication-related-osteonecrosis-of-the-jaw
#8
REVIEW
Natalie H Beth-Tasdogan, Benjamin Mayer, Heba Hussein, Oliver Zolk
BACKGROUND: Medication-related osteonecrosis of the jaw (MRONJ) is a severe adverse reaction experienced by some individuals to certain medicines commonly used in the treatment of cancer and osteoporosis (e.g. bisphosphonates, denosumab and antiangiogenic agents) and involves the progressive destruction of bone in the mandible or maxilla. Depending on the drug, its dosage, and the duration of exposure, the occurrence of this adverse drug reaction may be rare (e.g. following the oral administration of bisphosphonate or denosumab treatments for osteoporosis, or antiangiogenic agent-targeted cancer treatment) or common (e...
October 6, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28983705/comparative-adherence-to-weekly-oral-and-quarterly-intravenous-bisphosphonates-among-patients-with-limited-heath-literacy-who-sustained-distal-radius-fractures
#9
Young Hak Roh, Jung Ho Noh, Hyun Sik Gong, Goo Hyun Baek
Individuals with limited health literacy (HL) are less likely to obtain preventive care. We designed a study to compare adherence to weekly oral and quarterly intravenous bisphosphonates among patients with low HL. The study enrolled a total of 432 female patients who presented with a distal radius fracture caused by low-energy trauma. Participant HL was measured using the Newest Vital Sign tool, and patients were randomized to weekly oral or quarterly intravenous bisphosphonate groups. Subjects in the intravenous bisphosphonate group received intravenous injections of 3 mg ibandronate every 3 months, and those in the oral bisphosphonate group self-administered 70 mg alendronate orally once each week for 12 months...
October 5, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28983607/iguratimod-prevents-ovariectomy%C3%A2-induced-bone-loss-and-suppresses-osteoclastogenesis-via-inhibition-of-peroxisome-proliferator%C3%A2-activated-receptor%C3%A2-%C3%AE
#10
Ying-Xing Wu, Yue Sun, Ya-Ping Ye, Peng Zhang, Jia-Chao Guo, Jun-Ming Huang, Xing-Zhi Jing, Wei Xiang, Shi-Ying Yu, Feng-Jing Guo
Iguratimod is known for its anti‑inflammatory activities and therapeutic effects in patients with rheumatoid arthritis. It has previously been demonstrated that iguratimod attenuates bone destruction and osteoclast formation in the Walker 256 rat mammary gland carcinoma cell‑induced bone cancer pain model. Therefore, it was hypothesized that iguratimod may additionally exhibit therapeutic effects on benign osteoclast‑associated diseases including postmenopausal osteoporosis. In the present study, ovariectomized mice were used to investigate the effects of iguratimod in vivo...
September 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28982605/improvement-in-the-rate-of-inadequate-pharmaceutical-treatment-by-orthopaedic-surgeons-for-the-prevention-of-a-second-fracture-over-the-last-10-years
#11
Kousuke Iba, Takayuki Dohke, Junichi Takada, Koichi Sasaki, Tomoko Sonoda, Megumi Hanaka, Suichi Miyano, Toshihiko Yamashita
BACKGROUND: We have previously reported that the low rate of osteoporosis patients treated with anti-osteoporotic drugs following surgical treatment for the first fragility fractures by orthopaedic surgeons during 3 years from 2000 to 2003 was only 13.1%. Ten years have now passed our previous study, and we hypothesized that the rate of appropriate pharmacologic treatment for the prevention of secondary fractures has improved. METHODS: We studied 730 osteoporosis patients (102 men and 628 women; average age of 78 years, range 33-102 years) who underwent surgical treatment for fragility fractures, during 3-year period from 2010 to 2012...
October 2, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28981600/emodin-promotes-the-osteogenesis-of-mc3t3-e1-cells-via-bmp-9-smad-pathway-and-exerts-a-preventive-effect-in-ovariectomized-rats
#12
Xiaojing Chen, Shuang Zhang, Xiaoting Chen, Yan Hu, Jin Wu, Shuyan Chen, Jing Chang, Genfa Wang, Yanhong Gao
Emodin, a natural anthraquinone extracted from the Chinese herbs rhubarb and giant knotweed rhizome, has been reported to enhance osteoblast differentiation. However, the mechanisms underlying its ability to regulate osteogenesis are unclear. The objective of this study was to determine the role of emodin in osteoblast function in vitro and its osteoprotective effect in vivo. Emodin enhanced the differentiation and mineralization of MC3T3-E1 cells, as evidenced by elevated alkaline phosphatase activity and increased number of mineralized nodules...
October 1, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28980156/pain-in-osteoporosis-from-pathophysiology-to-therapeutic-approach
#13
REVIEW
Antonino Catalano, Gabriella Martino, Nunziata Morabito, Claudia Scarcella, Agostino Gaudio, Giorgio Basile, Antonino Lasco
The high worldwide prevalence of osteoporosis means it is considered a serious public health concern, possibly leading to physical disability and an increased mortality rate. Although osteoporosis is known as a silent disease affecting aging populations, its primary symptom remains pain. Acute pain is reported by patients with osteoporosis-related fractures, but chronic pain, mainly back pain, is also a characteristic of severe osteoporosis. Pain is associated not only with fractures but also with bodily changes in patients with osteoporosis that may include sensory, affective, and cognitive aspects...
October 4, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28980049/effects-of-endogenous-hypercortisolism-on-bone-mrna-and-microrna-expression-in-humans
#14
Z E Belaya, T A Grebennikova, G A Melnichenko, A G Nikitin, A G Solodovnikov, O I Brovkina, A U Grigoriev, L Y Rozhinskaya, I I Dedov
Hypercortisolism in humans suppresses osteoblastogenesis and osteoblast function through the upregulation of Wnt-signaling antagonists (sclerostin, Dkk1) and changes in microRNAs levels (miR-125b-5p, miR-218-5p, miR-34a-5p, miR-188-3p, miR-199a-5p) which are associated with mesenchymal stem-cell commitment to adipocytes or cartilage cells over the osteoblasts. INTRODUCTION: The purpose of this study was to evaluate the responses of bone to chronic glucocorticoid (GC) excess by measuring the levels of selected mRNA and microRNA (miR) in bone samples of patients with Cushing's disease (CD)...
October 4, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28975328/correction-treatment-of-low-bone-density-or-osteoporosis-to-prevent-fractures-in-men-and-women
#15
(no author information available yet)
No abstract text is available yet for this article.
September 19, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28972264/three-dimensional-multifractal-analysis-of-trabecular-bone-under-clinical-computed-tomography
#16
Rodrigo Baravalle, Felix Thomsen, Claudio Delrieux, Yongtao Lu, Juan Carlos Gómez, Borko Stošsić, Tatijana Stošsić
PURPOSE: An adequate understanding of bone structural properties is critical for predicting fragility conditions caused by diseases such as osteoporosis, and in gauging the success of fracture prevention treatments. In this work we aim to develop multi-resolution image analysis techniques to extrapolate high-resolution images predictive power to images taken in clinical conditions. METHODS: We performed multifractal analysis (MFA) on a set of 17 ex-vivo human vertebrae clinical CT scans...
October 3, 2017: Medical Physics
https://www.readbyqxmd.com/read/28965215/danish-national-cross-sectional-observational-study-on-the-prevalence-of-prior-major-osteoporotic-fractures-in-adults-presenting-with-hip-fracture-limitations-and-scope-for-fracture-liaison-services-in-prevention-of-hip-fracture
#17
A Frederiksen, B Abrahamsen, P B Johansen, H A Sørensen
Fracture liaison services prevent hip fractures by identifying other osteoporotic fractures that generally debut at a younger age. However, this study showed that a minority of hip fracture patients are already known to the health services through having had prior osteoporotic fractures. Identification of vertebral fractures in particular is lacking. INTRODUCTION: The purpose of this study was to examine the prevalence of prior major osteoporotic fractures (MOF) in the prior 10 years preceding hip fracture in order to provide information about the potential for prevention of hip fractures by fracture liaison services (FLS)...
September 30, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28965154/trabecular-bone-score-in-men-and-women-with-impaired-fasting-glucose-and-diabetes
#18
Kara L Holloway, Lelia L F De Abreu, Didier Hans, Mark A Kotowicz, Muhammad A Sajjad, Natalie K Hyde, Julie A Pasco
Diabetes is associated with increased skeletal fragility, despite higher bone mineral density (BMD). Alternative measures are necessary to more accurately determine fracture risk in individuals with diabetes. Therefore, we aimed to describe the relationship between trabecular bone score (TBS) and normoglycaemia, impaired fasting glucose (IFG) and diabetes and determine whether TBS-adjusted FRAX (Aus) score differed between these groups. This study included 555 men (68.7 ± 12.2 years) and 514 women (62.0 ± 12...
September 30, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28963125/daily-parathyroid-hormone-administration-enhances-bone-turnover-and-preserves-bone-structure-after-severe-immobilization-induced-bone-loss
#19
Lauren Harlow, Karim Sahbani, Jeffry S Nyman, Christopher P Cardozo, William A Bauman, Hesham A Tawfeek
Immobilization, as a result of motor-complete spinal cord injury (SCI), is associated with severe osteoporosis. Whether parathyroid hormone (PTH) administration would reduce bone loss after SCI remains unclear. Thus, female mice underwent sham or surgery to produce complete spinal cord transection. PTH (80 μg/kg) or vehicle was injected subcutaneously (SC) daily starting on the day of surgery and continued for 35 days. Isolated tibias and femurs were examined by microcomputed tomography scanning (micro-CT) and histology and serum markers of bone turnover were measured...
September 2017: Physiological Reports
https://www.readbyqxmd.com/read/28962180/preventive-effects-of-polygonum-multiflorum-on-glucocorticoid-induced-osteoporosis-in-rats
#20
Manru Zhou, Jin Li, Jingkai Wu, Yajun Yang, Xiaobing Zeng, Xiaohua Lv, Liao Cui, Weimin Yao, Yuyu Liu
In Traditional Chinese Medicine, Polygonum multiflorum (PM) is known for its anti-aging properties. A previous study by our group showed that extracts of PM were able to prevent and treat bone loss in vivo, and the active components emodin and 2,3,5,4,-tetrahydroxystilbene-2-O-β-glucoside (TSG) promoted the osteogenic differentiation of mesenchymal stem cells in vitro. The aim of the present study was to investigate the preventive effects of PM on glucocorticoid-induced osteoporosis (GIO) in rats. A crude extract of PM was prepared with 75% ethanol, purified and enriched using a D-101 macroresin column and elution with 30% ethanol, and the material obtained was assessed by high-performance liquid chromatography...
September 2017: Experimental and Therapeutic Medicine
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