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Osteoporosis prevention

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https://www.readbyqxmd.com/read/28523945/prevention-of-postmenopausal-osteoporosis-in-chinese-women-a-5-year-double-blind-randomized-parallel-placebo-controlled-study
#1
S Y Ran, Q Yu, Y Chen, S Q Lin
OBJECTIVES: To observe the effectiveness and safety of menopause-related hormone therapy (MHT) to prevent bone loss in Chinese women during the menopausal transition and early menopause, as well as to evaluate the effects of 5-year MHT on overall health to add Level I evidence for the prevention of osteoporosis using MHT. DESIGN: This clinical study was a prospective, double-blind, randomized, parallel placebo-controlled study. Chinese women in the menopausal transition and early menopause were randomly allocated to the MHT group or the placebo group...
May 19, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28521691/prospect-of-combination-and-sequential-therapies-for-postmenopausal-osteoporosis
#2
Hao Liu, Binbin Li
BACKGROUND: Osteoporosis is a systemic bone disease, which is associated with the osteoporotic fracture. Along with prolonged life expectancy, the fracture risk increases dramatically with age. So far, it is usually the first choice to using antiresorptive agents. However, current clinical therapeutic treatments are not enough to inhibit the long-term bone loss and the rising risk of bone fractures. Recently, sequential and combination therapies with anti-osteoporosis drugs have become an inevitable trend...
May 16, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28521374/phytochemistry-and-pharmacology-of-ferula-hermonis-boiss-a-review
#3
Zohreh Sattar, Mehrdad Iranshahi
Ferula hermonis, a well-known species of the genus Ferula found in Lebanon and Syria, has a brilliant history in traditional medicine as it has been used for the treatment of erectile dysfunction in men and menopausal disturbances in women. Thanks to modern pharmacological and clinical investigations, F. hermonis is a valuable medicinal and condimental plant that may be used for the treatment of impotence and diabetes, the prevention of osteoporosis, and possesses anti-microbial and anti-inflammatory properties...
May 18, 2017: Drug Research
https://www.readbyqxmd.com/read/28516878/high-incidence-of-vertebral-osteoporotic-fracture-within-the-first-year-after-liver-transplantation
#4
Sarah Butin, Isabelle Griffoul, Fabien Espitalier, Ephrem Salamé, Denis Mulleman, Philippe Goupille
OBJECTIVES: Bone loss is a complication for patients with liver diseases and after transplantation, which results in increased fracture risk. The aim of this study was to determine the incidence of osteoporotic vertebral fractures following liver transplantation. METHODS: We performed a prospective study of patients who were awaiting liver transplantation. Patients were seen at baseline (visit 1) and one year after transplantation (visit 2). At each visit, risk factors of osteoporosis were collected, biochemical tests were performed and bone mineral density with Vertebral Fracture Assessment was assessed...
April 29, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28516070/bone-density-in-postmenopausal-women-with-or-without-breast-arterial-calcification
#5
Atoosa Adibi, Farnaz Rabani, Silva Hovsepian
BACKGROUND: Identification of osteoporosis in women in order to prevent its related morbidity and mortality is considered a priority. Routine mammography is performed on all menopausal women as a screening tool. Determination of the relation between breast arterial calcification (BAC) on mammography and the bone density of this high-risk population could help us to determine those with osteoporosis. The aim of this study was to investigate the mentioned probable relation between BAC and osteoporosis...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28513571/fat-sugar-and-bone-health-a-complex-relationship
#6
REVIEW
Li Tian, Xijie Yu
With people aging, osteoporosis is expected to increase notably. Nutritional status is a relatively easily-modified risk factor, associated with many chronic diseases, and is involved in obesity, diabetes, and coronary heart disease (CHD), along with osteoporosis. Nutrients, such as fats, sugars, and proteins, play a primary function in bone metabolism and maintaining bone health. In Western nations, diets are generally high in saturated fats, however, currently, the nutritional patterns dominating in China continue to be high in carbohydrates from starch, cereals, and sugars...
May 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28512276/osteoporosis-knowledge-and-related-health-behavior-among-women-in-jazan-region-kingdom-of-saudi-arabia
#7
Ismail A Darout, Abdelwhab Alamir, Sameena Sultana
INTRODUCTION: Osteoporosis is a systemic bone disease that can be prevented to some extent by awareness of its risk factors and related health behavior. The aim of this study was to collect information about knowledge and awareness of osteoporosis among women living in Jazan and to describe the type of food habits, sociodemographic characteristics, and other osteoporosis-related health behavior. MATERIALS AND METHODS: Self-administered questionnaires were used for data collection...
May 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28510268/effect-of-intervention-initiation-timing-of-pulsed-electromagnetic-field-on-ovariectomy-induced-osteoporosis-in-rats
#8
Jun Zhou, Yuan Liao, Yahua Zeng, Haitao Xie, Chengxiao Fu, Neng Li
The aim of this study is to explore the effect of timing of initiation of pulsed electromagnetic field (PEMF) therapy on bone mass, microarchitecture, and biomechanical properties, and to investigate receptor activator of NF-kB (RANK) expression in ovariectomized (OVX) rats. Sixty female Sprague-Dawley rats were randomly divided into two equal batches of three groups each (10 rats in each group). The first batch comprised of sham-operated (Sham-0 group), ovariectomized (OVX-0 group), and ovariectomized plus treated with PEMF starting from the day of OVX (Early PEMF group)...
May 16, 2017: Bioelectromagnetics
https://www.readbyqxmd.com/read/28509822/fracture-prevention-in-the-orthopaedic-environment-outcomes-of-a-coordinator-based-fracture-liaison-service
#9
Earl R Bogoch, Victoria Elliot-Gibson, Dorcas Beaton, Joanna Sale, Robert G Josse
BACKGROUND: Fracture liaison services focus on secondary fracture prevention by identifying patients at risk for future fracture and initiating appropriate evaluation, risk assessment, education, and therapeutic intervention. This study describes key clinical outcomes including bone mineral densitometry, physician assessment, and pharmacotherapy initiation in pharmacotherapy-naïve patients undergoing treatment for fragility fracture in a Canadian fracture liaison service. METHODS: We determined rates of post-fracture investigation and treatment for inpatients and outpatients with a fragility fracture seen in a coordinator-based fracture liaison service at an urban university trauma hospital...
May 17, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28507534/stress-and-alterations-in-bones-an-interdisciplinary-perspective
#10
REVIEW
Pia-Maria Wippert, Michael Rector, Gisela Kuhn, Karin Wuertz-Kozak
Decades of research have demonstrated that physical stress (PS) stimulates bone remodeling and affects bone structure and function through complex mechanotransduction mechanisms. Recent research has laid ground to the hypothesis that mental stress (MS) also influences bone biology, eventually leading to osteoporosis and increased bone fracture risk. These effects are likely exerted by modulation of hypothalamic-pituitary-adrenal axis activity, resulting in an altered release of growth hormones, glucocorticoids and cytokines, as demonstrated in human and animal studies...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28505102/bone-protective-effects-of-dried-plum-in-postmenopausal-women-efficacy-and-possible-mechanisms
#11
REVIEW
Bahram H Arjmandi, Sarah A Johnson, Shirin Pourafshar, Negin Navaei, Kelli S George, Shirin Hooshmand, Sheau C Chai, Neda S Akhavan
Osteoporosis is an age-related chronic disease characterized by a loss of bone mass and quality, and is associated with an increased risk of fragility fractures. Postmenopausal women are at the greatest risk of developing osteoporosis due to the cessation in ovarian hormone production, which causes accelerated bone loss. As the demographic shifts to a more aged population, a growing number of postmenopausal women will be afflicted with osteoporosis. Certain lifestyle factors, including nutrition and exercise, are known to reduce the risk of developing osteoporosis and therefore play an important role in bone health...
May 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28500874/effects-of-intermittent-low-dose-parathyroid-hormone-treatment-on-rapid-mandibular-distraction-osteogenesis-in-rabbits
#12
Bin Ye, Yunfeng Li, Songsong Zhu, Shengjun Sun, Jing Hu, Shujuan Zou
PURPOSE: To determine whether low-dose recombinant human parathyroid hormone (rhPTH) would have a beneficial effect on regenerate healing and surrounding bone in a rabbit model of rapid mandibular distraction osteogenesis (DO). MATERIALS AND METHODS: Twenty-eight rabbits underwent unilateral mandibular lengthening at a rapid rate of 2 mm per day for 5 days. From the first day of DO, the experimental group received daily subcutaneous injections of rhPTH 10 μg/kg for 30 days and the control group received the same volume of saline (n = 14 in each group)...
April 19, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28498448/sanguinarine-protects-against-ovariectomy%C3%A2-induced-osteoporosis-in-mice
#13
Yan Ma, Junjie Chu, Jianjun Ma, Lei Ning, Ke Zhou, Xiangqian Fang
Natural compounds are alternative agents that have therapeutic potential for preventing and treating osteoporosis. Traditionally, sanguinarine has been used clinically due to its diverse biological properties, including antimicrobial, anti‑inflammatory and anticancer effects. Recently, for the first time, it was reported that sanguinarine inhibits osteoclast differentiation and bone resorption by suppressing the tumor necrosis factor ligand superfamily member 11‑induced nuclear factor‑κB and extracellular signal‑regulated kinase signaling pathways in vitro...
May 11, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28497667/midline-lumbar-fusion-with-cortical-bone-trajectory-as-first-line-treatment-in-a-selected-series-of-patients-with-lumbar-instability
#14
Mattia Bruzzo, Paolo Severi, Susanna Bacigaluppi
OBJECT: Aim of the present study was to proof that for certain complex spinal conditions, MIDLIF technique is very convenient in terms of length of hospitalization, functional recovery and pain relief and time to back to work. METHODS: MIDLF indications were set for patients with not more than 3 unstable levels, presence of osteoporosis (alternative to cemented screws), or cardiomyopathy with anticoagulation with or without spinal stenosis, and or discopathy. Surgical difficulties, operative time, hemoglobin loss and postoperative 45 days, 6 months and one-year follow- up data are shown...
May 11, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28497215/evidence-based-prevention-and-treatment-of-osteoporosis-after-spinal-cord-injury-a-systematic-review
#15
REVIEW
Saeed Soleyman-Jahi, Ali Yousefian, Radin Maheronnaghsh, Farhad Shokraneh, Shayan Abdollah Zadegan, Akbar Soltani, Seyed Mostafa Hosseini, Alexander R Vaccaro, Vafa Rahimi-Movaghar
PURPOSE: Spinal cord injury (SCI) results in accelerated bone mineral density (BMD) loss and disorganization of trabecular bone architecture. The mechanisms underlying post-SCI osteoporosis are complex and different from other types of osteoporosis. Findings of studies investigating efficacy of pharmacological or rehabilitative interventions in SCI-related osteoporosis are controversial. The aim of this study was to review the literature pertaining to prevention and evidence-based treatments of SCI-related osteoporosis...
May 11, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28496491/the-effects-of-transdermal-estrogen-delivery-on-bone-mineral-density-in-postmenopausal-women-a-meta-analysis
#16
Fatemeh Abdi, Hamid Mobedi, Farhad Bayat, Nariman Mosaffa, Mahrokh Dolatian, Fahimeh Ramezani Tehrani
Due to its minimal systematic adverse effects, transdermal estrogen is widely used for the prevention of osteoporosis in postmenopausal women. The present meta-analysis aimed to clarify the effects of transdermal estrogen on bone mineral density (BMD) of postmenopausal women. Studies were identified by searching electronic databases including Cochrane Library, MEDLINE, Embase , and CINAHL databases, and also the Sciences Citation Index. Systematic review of articles was published between January 1989 to February 2016...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28494718/osteoimmunology-offers-new-perspectives-for-the-treatment-of-pathological-bone-loss
#17
Hongrui Liu, Tingting Luo, Jiali Tan, Minqi Li, Jie Guo
New evidence of the interactions between the immune system and bone has accumulated in bone diseases, including osteoporosis, periodontitis and rheumatoid arthritis. A marked imbalance between bone resorption and formation is central to the onset of pathological bone loss. Osteoimmunology has revealed that the immune system, including T cells, B cells and inflammatory cytokines, is a key regulator of both osteoclasts and osteoblasts. Th1 cells, which differentiate from CD4+T cells, are thought to play a major function during bone loss...
May 11, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28492856/treatment-of-low-bone-density-or-osteoporosis-to-prevent-fractures-in-men-and-women-a-clinical-practice-guideline-update-from-the-american-college-of-physicians
#18
Amir Qaseem, Mary Ann Forciea, Robert M McLean, Thomas D Denberg
Description: This guideline updates the 2008 American College of Physicians (ACP) recommendations on treatment of low bone density and osteoporosis to prevent fractures in men and women. This guideline is endorsed by the American Academy of Family Physicians. Methods: The ACP Clinical Guidelines Committee based these recommendations on a systematic review of randomized controlled trials; systematic reviews; large observational studies (for adverse events); and case reports (for rare events) that were published between 2 January 2005 and 3 June 2011...
May 9, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28492833/treatment-of-low-bone-density-or-osteoporosis-to-prevent-fracture
#19
(no author information available yet)
No abstract text is available yet for this article.
May 9, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28492609/the-risk-of-osteoporosis-in-oral-steroid-treatment-for-nasal-polyposis-a-systematic-review
#20
L Winblad, C G Larsen, K Håkansson, B Abrahamsen, C von Buchwald
BACKGROUND: Systemic glucocorticoids are often used in the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP), and osteoporosis is a well-known complication to steroid treatment, associated with significant morbidity. Nevertheless, the burden of steroid induced osteoporosis is unknown in patients with CRSwNP. We aimed to assess the risk of acquiring osteoporosis caused by oral steroids in patients with CRSwNP, and provide recommendations on future research and guidelines. METHODOLOGY: Cochrane Review Database, EMBASE, Ovid Medline, and PubMed were searched for studies including adult patients with CRSwNP treated with oral steroids...
May 10, 2017: Rhinology
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