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Osteoporosis prevention

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https://www.readbyqxmd.com/read/29470854/the-cost-effectiveness-of-screening-in-the-community-to-reduce-osteoporotic-fractures-in-older-women-in-the-uk-economic-evaluation-of-the-scoop-study
#1
David A Turner, Rebekah Fong Soe Khioe, Lee Shepstone, Elizabeth Lenaghan, Cyrus Cooper, Neil Gittoes, Nicholas C Harvey, Richard Holland, Amanda Howe, Eugene McCloskey, Terence W O'Neill, David Torgerson, Richard Fordham
The SCOOP study was a two-arm randomized controlled trial conducted in the UK in 12,483 eligible women aged 70 to 85 years. It compared a screening program using the FRAX® risk assessment tool in addition to bone mineral density (BMD) measures versus usual management. The SCOOP study found a reduction in the incidence of hip fractures in the screening arm, but there was no evidence of a reduction in the incidence of all osteoporosis-related fractures. To make decisions about whether to implement any screening program, we should also consider whether the program is likely to be a good use of health care resources, ie, is it cost-effective? The cost per gained quality adjusted life year of screening for fracture risk has not previously been demonstrated in an economic evaluation alongside a clinical trial...
February 22, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29470611/osteoporosis-in-rheumatic-diseases-anti-rheumatic-drugs-and-the-skeleton
#2
REVIEW
Alanna M Dubrovsky, Mie Jin Lim, Nancy E Lane
Osteoporosis in rheumatic diseases is a very well-known complication. Systemic inflammation results in both generalized and localized bone loss and erosions. Recently, increased knowledge of inflammatory process in rheumatic diseases has resulted in the development of potent inhibitors of the cytokines, the biologic DMARDs. These treatments reduce systemic inflammation and have some effect on the generalized and localized bone loss. Progression of bone erosion was slowed by TNF, IL-6 and IL-1 inhibitors, a JAK inhibitor, a CTLA4 agonist, and rituximab...
February 22, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29469715/assessment-of-risk-and-use-of-prophylaxis-for-glucocorticoidinduced-osteoporosis-among-dermatologists-in-the-pacific-northwest-a-survey-study
#3
Eliza Notaro, Nicole Fett, Michi M Shinohara
OBJECTIVE: Exposure to even physiologic doses of glucocorticoids can reduce one's bone mass and increase risk for osteoporotic fracture. There currently exists a wide variation in clinician approach to the assessment and management of glucocorticoid-induced osteoporosis (GIO). Our objectives were to characterize Pacific Northwest dermatology providers' general practices, assessment of risk for GIO, and preferred GIO prophylaxis measures by way of survey. To identify whether knowledge deficits exist with respect to preventing and managing GIO in dermatology patients...
September 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29462059/effects-of-ultra-early-hyperbaric-oxygen-therapy-on-femoral-calcitonin-gene-related-peptide-and-bone-metabolism-of-rats-with-complete-spinal-transection
#4
Min Liu, Huan Chen, Min Tong, Jinping Zhou, Xiyu Wu
STUDY DESIGN: Seventy-five Sprague-Dawley (SD)rats were randomly divided into sham, complete spinal cord transection (CSCT)and hyperbaric oxygen (HBO) groups. Among them, rats in HBO group were further divided into 3 h group (HBO1) and 12 h group (HBO2). OBJECTIVE: To study the effects of ultra-early HBO therapy on femoral calcitonin gene-related peptide (CGRP) and bone metabolism of rats with CSCT. SUMMARY OF BACKGROUND DATA: Complete SCI is still an unresolved problem in clinical practice...
February 16, 2018: Spine
https://www.readbyqxmd.com/read/29460102/economic-impact-and-cost-effectiveness-of-fracture-liaison-services-a-systematic-review-of-the-literature
#5
REVIEW
C-H Wu, I-J Kao, W-C Hung, S-C Lin, H-C Liu, M-H Hsieh, S Bagga, M Achra, T-T Cheng, R-S Yang
Fracture liaison services (FLS), implemented in different ways and countries, are reported to be a cost-effective or even a cost-saving secondary fracture prevention strategy. This presumed favorable cost-benefit relationship is encouraging and lends support to expanded implementation of FLS per International Osteoporosis Foundation Best Practice Standards. This study summarizes the economic impact and cost-effectiveness of FLS implemented to reduce subsequent fractures in individuals with osteoporosis. This systematic review identified studies reporting economic outcomes for FLS in osteoporotic patients aged 50 and older through a comprehensive search of MEDLINE, EMBASE, Cochrane Central, and PubMed of studies published January, 2000 to December, 2016...
February 19, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29457433/-effect-of-50-hz-1-8-mt-sinusoidal-electromagnetic-fields-on-bone-mineral-density-in-growing-rats
#6
Yu-Hai Gao, Yan-Feng Zhou, Shao-Feng Li, Wen-Yuan Li, Hui-Rong Xi, Fang-Fang Yang, Ke-Ming Chen
OBJECTIVE: To study effects of 50 Hz 1.8 mT sinusoidal electromagnetic fields (SEMFs) on bone mineral density (BMD) in SD rats. METHODS: Thirty SD rats weighted(110±10) and aged 1 month were randomly divided into control group and electromagnetic field group, 15 in each group. Normal control group of 50 Hz 0 mT density and sinusoidal electromagnetic field group of 50 Hz 1.8 mT were performed respectively with 1.5 h/d and weighted weight once a week, and observed food-intake...
December 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29455485/-risk-factors-of-non-surgical-vertebral-fracture-after-percutaneous-kyphoplasty-of-single-segment-thoracolumbar-fracture
#7
Jian Wu, Yue-Hong Guan, Sheng-Li Fan
OBJECTIVE: To investigate the risk factors of non-surgical vertebral fracture after percutaneous kyphoplasty (PKP) in patients with single segment thoracolumbar osteoporotic vertebral compression fracture(OVCF). METHODS: The clinical data of 219 patients with single segment thoracolumbar osteoporotic vertebral compression fracture underwent percutaneous kyphoplasty from January 2010 to December 2015 were retrospectively analyzed. There were 29 cases in non-surgical vertebral body fracture group with 7 males and 22 females aged (67...
September 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29455249/multiple-vertebral-fractures-following-osteoporosis-treatment-discontinuation-a-case-report-after-long-term-odanacatib
#8
N Binkley, D Krueger, A E de Papp
INTRODUCTION: Case reports of women sustaining multiple vertebral fractures (VF) soon afterdenosumab discontinuation are accumulating. METHODS: We report a woman with five new vertebral fractures in ~8 months following discontinuation of long-term odanacatib (ODN), an experimental cathepsin K inhibitor. RESULTS: DXA examination demonstrated an ~12% decline in bone mineral density (BMD) and ~9% decline in trabecular bone score (TBS) since ODN discontinuation...
February 18, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29442051/3-4-7-8-tetrahydroxyflavone-inhibits-rankl-induced-osteoclast-formation-and-bone-resorption
#9
J H Kang, H Jung, M Yim
Osteoclasts, which are specialized bone multinuclear cells, are responsible for bone lytic diseases such as osteoporosis. 3',4',7,8-tetrahydroxyflavone is a flavonoid from Acacia confusa. In the present study, we found that 3',4',7,8-tetrahydroxyflavone markedly inhibited receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclastic differentiation from mouse bone marrow-derived macrophages (BMMs). 3',4',7,8-tetrahydroxyflavone also reduced the mRNA expression levels of osteoclastic marker genes including the calcitonin receptor (CTR) and cathepsin K...
March 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29440373/calcium-supplementation-in-osteoporosis-useful-or-harmful
#10
Iacopo Chiodini, Mark J Bolland
Osteoporosis and fragility fractures are important social and economic problems worldwide and are due to both the loss of bone mineral density and sarcopenia. Indeed, fragility fractures are associated with increased disability, morbidity and mortality. It is known that a normal calcium balance together with a normal vitamin D status is important for maintaining well-balanced bone metabolism and for many years calcium and vitamin D has been considered crucial in the prevention and treatment of osteoporosis...
February 12, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29437027/benefits-of-olive-oil-phenolic-compounds-in-disease-prevention
#11
Olga Garcia-Martinez, Concepcion Ruiz, Alvaro Gutierrez-Ibanez, Rebeca Illescas-Montes, Lucia Melguizo-Rodriguez
BACKGROUND AND OBJECTIVE: The preventive effects of olive oil against different diseases have been attributed to its high phenolic compound content. The objective of this study was to examine available scientific evidence on the beneficial effects against chronic diseases of olive oil phenolic compounds. METHOD: This article examines recently published data on olive oil phenolic compounds and their potential benefits in the prevention of cardiovascular disease, cancer, neurodegenerative disease, and osteoporosis...
February 12, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29435826/efficacy-of-bovine-lactoferrin-in-the-post-surgical-treatment-of-patients-suffering-from-bisphosphonate-related-osteonecrosis-of-the-jaws-an-open-label-study
#12
Francesco Calvani, Antimo Cutone, Maria Stefania Lepanto, Luigi Rosa, Valentino Valentini, Piera Valenti
Osteonecrosis of the jaws is an emerging pathological condition characterized by un-exposure or exposure of the necrotic bone, independently from the etiology. This term is usually referred to medication-related osteonecrosis of the jaws due to severe adverse reaction to certain medicines, as bisphosphonates, used for the treatment of cancer and osteoporosis. The management of patients with Bisphosphonate-Related Osteonecrosis of the Jaws (BRONJ) remains challenging because surgical and medical interventions may not eradicate this pathology...
February 12, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29432652/osteonecrosis-of-the-jaws-a-14-year-retrospective-survey-of-hospital-admissions
#13
Kelly McGowan, Saso Ivanovski, Caroline Acton
BACKGROUND: Osteonecrosis of the jaw (ONJ) is a serious complication of both radiation and antiresorptive therapies. This study aimed to determine how many patients have been treated for medication-related osteonecrosis of the jaws (MRONJ) and osteoradionecrosis (ORN), and whether the number of diagnoses has decreased over time with improved awareness and preventative measures. METHODS: Medical records at the Royal Brisbane & Women's Hospital, Gold Coast University Hospital, and Robina Hospital were reviewed to identify patients diagnosed with MRONJ and ORN between January 2003 - May 2017...
February 12, 2018: Australian Dental Journal
https://www.readbyqxmd.com/read/29429033/implementing-a-fracture-liaison-service-open-model-of-care-utilizing-a-cloud-based-tool
#14
S L Greenspan, A Singer, K Vujevich, B Marchand, D A Thompson, Y-J Hsu, D Vaidya, L S Stern, D Zeldow, D B Lee, S Karp, R Recker
PURPOSE: Although half of women and one-quarter of men aged 50 and older will sustain an acute low-trauma fracture, less than a quarter receive appropriate secondary fracture prevention. The goal of this quality improvement demonstration project was to implement a Fracture Liaison Service (FLS) focused on secondary prevention of an osteoporotic fracture in three open health care systems aided by a cloud-based tool. METHODS: The pre-post study design examined the proportion of men and women over age 50 who received appropriate assessment (bone mineral density, vitamin D levels) and treatment (calcium/vitamin D, pharmacologic therapy) in the six months following a recently diagnosed fracture...
February 10, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29428397/pyk2-deficiency-potentiates-osteoblast-differentiation-and-mineralizing-activity-in-response-to-estrogen-and-raloxifene
#15
Sumana Posritong, Jung Min Hong, Pierre P Eleniste, Patrick W McIntyre, Jennifer L Wu, Evan R Himes, Vruti Patel, Melissa A Kacena, Angela Bruzzaniti
Bone remodeling is controlled by the actions of bone-degrading osteoclasts and bone-forming osteoblasts (OBs). Aging and loss of estrogen after menopause affects bone mass and quality. Estrogen therapy, including selective estrogen receptor modulators (SERMs), can prevent bone loss and increase bone mineral density in post-menopausal women. Although investigations of the effects of estrogen on osteoclast activity are well advanced, the mechanism of action of estrogen on OBs is still unclear. The proline-rich tyrosine kinase 2 (Pyk2) is important for bone formation and female mice lacking Pyk2 (Pyk2-KO) exhibit elevated bone mass, increased bone formation rate and reduced osteoclast activity...
February 8, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29425296/inhibiting-cellular-senescence-a-new-therapeutic-paradigm-for-age-related-osteoporosis
#16
Sundeep Khosla, Joshua N Farr, James L Kirkland
Context: With the aging of the population and projected increase in osteoporotic fractures, coupled with the declining use of osteoporosis medications, there is a compelling need for new approaches to treat osteoporosis. Given that age-related osteoporosis generally co-exists with multiple other co-morbidities (e.g., atherosclerosis, diabetes, frailty), all sharing aging itself as the leading risk factor, there is growing interest in the "Geroscience Hypothesis", which posits that manipulation of fundamental aging mechanisms will delay the appearance or severity of multiple chronic diseases because these diseases share the same underlying risk factor - age...
February 7, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29422485/is-the-word-osteoporosis-a-reason-for-kinesiophobia
#17
Zafer Gunendi, Dilek Eker, Duygu Tecer, Belgin Karaoglan
BACKGROUND: Osteoporosis is a systemic skeletal disease that causes weakening of the bones which increases the risk of fractures. Especially hip fractures lead to substantial physical, psychological, social and economic burden both for the patients and the governments. Excercises and physically active life style are essential preventive and therapeutic approaches for osteoporosis. Kinesiophobia is an irrational fear of movement due to the belief of susceptibility to injury. It is associated with lower levels of physical activity...
February 7, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29422089/cement-pulmonary-embolism-as-a-complication-of-percutaneous-vertebroplasty-in-cancer-patients
#18
Asem Mansour, Nayef Abdel-Razeq, Hussein Abuali, Mohammad Makoseh, Nouran Shaikh-Salem, Kamelah Abushalha, Samer Salah
BACKGROUND: Vertebroplasty is a minimally invasive procedure commonly performed for vertebral compression fractures secondary to osteoporosis or malignancy. Leakage of bone cement into the paravertebral venous system and cement pulmonary embolism (cPE) are well described, mostly in patients with osteoporosis. Little is known about the clinical sequelae and outcomes in cancer patients. In this study, we report our experience with cPE following vertebroplasty performed in cancer patients...
February 8, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/29418016/bone-mineral-density-in-young-adults-with-prader-willi-syndrome-a-randomized-placebo-controlled-cross-over-gh-trial
#19
Stephany H Donze, Renske J Kuppens, Nienke E Bakker, Janiëlle A E M van Alfen-van der Velden, Anita C S Hokken-Koelega
CONTEXT: The prevalence of osteoporosis is increased in adults with Prader-Willi syndrome (PWS). In children with PWS, growth hormone (GH) treatment has beneficial effects on bone mineral density (BMD). BMD might deteriorate after cessation of GH at adult height (AH), while continuing GH might maintain BMD. OBJECTIVE: To investigate the effects of GH versus placebo, and furthermore the effects of sex steroid replacement therapy (SSRT), on BMD in GH-treated young adults with PWS who had attained AH...
February 8, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29415696/osteoporosis-knowledge-and-beliefs-in-diabetic-patients-a-cross-sectional-study-from-palestine
#20
Ghaith A Ishtaya, Yazan M Anabtawi, Sa'ed H Zyoud, Waleed M Sweileh
BACKGROUND: Osteoporosis is a potential metabolic complication of diabetes mellitus (DM). Therefore, patients with DM should have adequate osteoporosis knowledge and beliefs in order to get engaged in osteoporosis preventive behaviors. The objective of this study was to assess osteoporosis knowledge and beliefs among diabetic patients. METHODS: This was a cross sectional study carried out at Al-Makhfiah governmental primary healthcare unit in Nablus, Palestine from September 2016 to December 2016...
February 7, 2018: BMC Musculoskeletal Disorders
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