Jun Li, Ye-Ting Hu, Cheng-Cheng Liu, Liu-Hong Wang, Hai-Xing Ju, Xue-Feng Huang, Pan Chi, Jin-Lin Du, Jian-Ping Wang, Yi Xiao, Guo-Le Lin, Wei Zhang, Hong Zhao, Ming Liu, Yong-Mao Song, Dong Xu, Jian-Wei Wang, Li-Feng Sun, Hai-Ting Xie, Hong-Feng Cao, Qian Xiao, Jian Wang, Qing-Bin Wu, De-Chuan Li, Sheng Dai, Wei-Zhong Jiang, Li Shen, Ying Yuan, Zi-Qiang Wang, Ke-Feng Ding
PURPOSE: To determine whether LARC with negative mesorectal fascia (MRF) predicted by magnetic resonance imaging (MRI) can be excluded from preoperative radiotherapy treatment. METHOD: This multicenter, open-label, non-inferiority, randomized clinical trial enrolled patients with LARC within 6-12 cm from the anal verge and with negative MRI-predicted MRF. Participants were randomized to the intervention group (primary surgery, in which the patients with positive pathological circumferential margins (CRM) were subjected to CRT while negative CRM undergone adjuvant chemotherapy according to pathologic staging) or the control group (preoperative CRT, in which all patients were followed by surgery and adjuvant chemotherapy)...
January 5, 2024: International Journal of Radiation Oncology, Biology, Physics