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Mycosis fungoides

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https://www.readbyqxmd.com/read/29673747/-annular-lichenoid-dermatitis-of-youth-a-case-report-and-literature-review
#1
D Debois, J-L Dargent, P Ngendahayo, P-P Roquet-Gravy
BACKGROUND: Annular lichenoid dermatitis of youth (ALDY) is a rare form of dermatitis mainly affecting children and young people. All cases reported show a consistent clinical and histological picture. This is the first case described in the French literature. PATIENTS AND METHODS: A 5-year-old girl presented an annular isolated patch of the lower abdomen with an erythematosquamous border and central hypopigmentation for one year. Topical corticosteroids and pimecrolimus proved effective but relapse occurred after treatment withdrawal...
April 16, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29660166/lymphomatoid-papulosis-with-folliculotropism-eccrinotropism-and-neurotropism
#2
Wei Ba, Yi Yang, Ziyan Zhang, Xuanjin Wei, Wenjuan Wang, Zigang Zhao, Liqiang Zheng, Chengxin Li
The histopathological characteristics of lymphomatoid papulosis (LyP) vary. Currently, six subtypes have been reported, including a new subtype with perifollicular infiltration and different degrees of folliculotropism of CD30+ atypical lymphocytes, known as follicular LyP. However, LyP pathologically manifesting with folliculotropism, eccrinotropism and neurotropism has been rarely reported. We present a case of LyP demonstrating CD30+ atypical lymphocytes around the hair follicle, eccrine gland and neurofiber, with varying degrees of infiltrates...
April 16, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29644193/nonvenereal-penile-dermatoses-a-retrospective-study
#3
Ana Marcos-Pinto, Luís Soares-de-Almeida, João Borges-Costa
Context: A variety of nonvenereal diseases can affect the penis and diminish quality of life. Many present similar clinical features and a cutaneous biopsy may be necessary to clarify the diagnosis. Aims: To characterize nonvenereal penile dermatoses with histological confirmation in a southwestern Europe hospital during a 9-year period. Materials and Methods: A retrospective study was conducted. We reviewed all penile biopsies performed between January 1, 2007 and December 31, 2015 and studied the causes of the nonvenereal penile dermatoses...
March 2018: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29616855/clinically-defined-subgroups-of-mycosis-fungoides-display-differing-histopathological-features-at-initial-biopsy
#4
Ulrike Wehkamp, Michael Weichenthal, Friederike Egberts, Thomas Schwarz, Wolfram Klapper, Ilske Oschlies
Most patients with mycosis fungoides (MF) remain in early disease stages but some progress to tumor stage. The individual course of the disease cannot be predicted. We wanted to assess the clinical and histological characteristics of the first available biopsy. An end-of-spectrum approach with two groups was used, comparing MF remaining long-term stable in T1a ('MF stable') and MF with later tumor development or present T3 stage ('MF tumor'). The clinical and histomorphological features of the initial skin biopsy were compared...
April 4, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29607757/cutaneous-hematolymphoid-and-histiocytic-proliferations-in-children
#5
Alejandro A Gru, Louis P Dehner
This article focuses on cutaneous hematopoietic neoplasms that are more likely to be encountered in the pediatric age-group and includes both lymphoproliferative and histiocytic disorders. The cutaneous hematologic disorders in children have a different epidemiologic profile to what is seen during adulthood. Although mycosis fungoides is the most frequent form of cutaneous lymphoma in adults, it is very rare in children. Because lymphoblastic leukemias and lymphomas are more frequent in the pediatric setting, cutaneous leukemic infiltrates are relatively common in this age-group...
March 2018: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/29606946/the-importance-of-excluding-cutaneous-t-cell-lymphomas-in-patients-with-a-working-diagnosis-of-papuloerythroderma-of-ofuji-a-case-series
#6
Anthony M Maher, Chloé E Ward, Steven Glassman, Ivan V Litvinov
Papuloerythroderma of Ofuji (PEO) is an erythroderma-like eruption with flat-topped papules that spare the skin folds (a "deck-chair sign" finding). Many infections, medications, and systemic diseases have been associated with PEO, including cutaneous T-cell lymphomas (CTCL). The relationship between the clinical presentation of PEO and CTCL remains poorly elucidated. Clinical, laboratory, and histopathological data were obtained from the Lymphoma Clinic at the Ottawa Hospital, Canada. We report 5 patients with deck-chair-sign-positive CTCL, mycosis fungoides, and Sézary syndrome variants...
January 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29606817/folliculotropic-mycosis-fungoides-in-20-korean-cases-clinical-and-histopathologic-features-and-response-to-ultraviolet-a-1-and-or-photodynamic-therapy
#7
Min Soo Jang, Ji Yun Jang, Jong Bin Park, Dong Young Kang, Jin Woo Lee, Taek Geun Lee, Hyun Hwangbo, Kee Suck Suh
Background: Folliculotropic mycosis fungoides (FMF) is a variant of mycosis fungoides (MF) that is characterized clinically by variable types of skin eruptions, including plaques, acneiform lesions, and alopecic patches. Histopathologically, FMF is characterized by folliculotropic infiltrates. Objective: This study was conducted to scrutinize the clinical and histopathologic features of FMF in Koreans and the responses to phototherapy. Methods: Twenty Koreans diagnosed with MF who had histopathologic evidence of folliculotropism were enrolled...
April 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29605670/serum-soluble-cd48-levels-as-a-prognostic-marker-in-mycosis-fungoides-and-s%C3%A3-zary-syndrome
#8
Tomonori Oka, Tomomitsu Miyagaki, Naomi Takahashi, Rina Nakajima, Hiroaki Kamijo, Hiraku Suga, Yoshihide Asano, Makoto Sugaya, Shinichi Sato
No abstract text is available yet for this article.
March 29, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29603522/re-infection-of-toxoplasma-gondii-after-hsct-presenting-lymphadenopathy-resembling-recurrence-of-lymphoma
#9
Junichi Hashiguchi, Masahiro Onozawa, Tomoaki Naka, Kanako C Hatanaka, Souichi Shiratori, Junichi Sugita, Katsuya Fujimoto, Yoshihiro Matsuno, Takanori Teshima
Toxoplasma gondii (T. gondii) reactivation is one of the fatal complications after hematopoietic stem cell transplantation (HSCT); however, re-infection has not been reported. Here we report a case of mycosis fungoides in which cervical lymphadenopathy developed after HSCT. Initially, recurrent lymphoma was suspected. However, biopsy of the lymph node showed typical histology of toxoplasmosis and serology showed re-infection of T. gondii. Toxoplasmosis needs to be differentiated for cases with lymphoadenopthy after HSCT...
March 30, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29603194/immune-privilege-disruption-in-folliculotropic-mycosis-fungoides-investigation-of-major-histocompatibility-complex-antigen-expression
#10
Janyana M D Deonizio, Joan Guitart, Pedram Yazdan, Fabiane Mulinari-Brenner, Mirian N Sotto, José A Sanches
BACKGROUND: Folliculotropic mycosis fungoides (FMF) is a cutaneous T-cell lymphoma mainly affecting the hair follicle, which seems to represent a place of immune privilege phenomenon. OBJECTIVES: To explore a possible role of immune privilege (IP) in FMF analyzing the major histocompatibility complex (MHC) expression. METHODS: Immunohistochemistry for HLA-G and MHC-II was performed to formalin-fixed paraffin-embedded cutaneous skin biopsies of FMF patients (n = 43), conventional mycosis fungoides (CMF; n = 13), alopecia areata (AA; n = 13), and normal scalp skin (NS; n = 12)...
March 30, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29572582/systemic-treatment-options-for-advanced-stage-mycosis-fungoides-and-s%C3%A3-zary-syndrome
#11
REVIEW
Louise Photiou, Carrie van der Weyden, Christopher McCormack, H Miles Prince
PURPOSE OF REVIEW: Cutaneous T-cell lymphoma (CTCL) is a rare form of non-Hodgkin lymphoma. Globally, the most common subtypes of CTCL are mycosis fungoides and Sézary syndrome. CTCL can confer significant morbidity and even mortality in advanced disease. Here we review the current and potential future treatments for advanced-stage CTCL. RECENT FINDINGS: Heterogeneity of treatment choice has been demonstrated both in US and non-US centers. Systemic treatment choice is currently guided by prognostic features, incorporating stage, immunophenotypic and molecular findings, and patient-specific factors such as age and comorbidities...
March 23, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29571300/erythroderma-and-extensive-poikiloderma-a-rare-initial-presentation-of-dermatomyositis-a-case-report
#12
H M M T B Herath, B S D P Keragala, S P Pahalagamage, G H C C Janappriya, Aruna Kulatunga, C N Gunasekera
BACKGROUND: Dermatomyositis is a humoral-mediated inflammatory myopathy with symmetrical proximal muscle weakness and dermatological manifestations such as Gottron's papules, heliotrope rash, periungual abnormalities, and flagellate erythema. Erythroderma is a severe and potentially life-threatening dermatological condition with diffuse erythema and scaling involving more than 90% of the skin surface area. Poikiloderma vasculare atrophicans refers to mottled hyperpigmentation and hypopigmentation of the skin with in-between telangiectases and areas of atrophy and is considered a variant of mycosis fungoides...
March 24, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29564882/alopecia-areata-like-mycosis-fungoides-lions-for-lambs
#13
Alessandro Pileri, Claudio Agostinelli, Francesca Bruni, Vieri Grandi, Aurora Alessandrini, Nicola Pimpinelli, Bianca M Piraccini
No abstract text is available yet for this article.
April 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29543675/the-use-of-central-pathology-review-with-digital-slide-scanning-in-advanced-stage-mycosis-fungoides-and-s%C3%A3-zary-syndrome-a-multi-institutional-and-international-pathology-study
#14
Alejandro A Gru, Jinah Kim, Melissa Pulitzer, Joan Guitart, Maxime Battistella, Gary S Wood, Lorenzo Cerroni, Werner Kempf, Rein Willemze, Joya Pawade, Christiane Querfeld, Andras Schaffer, Laura Pincus, Michael Tetzlaff, Madeleine Duvic, Julia Scarisbrick, Pierluigi Porcu, Aaron R Mangold, David J Dicaudio, Michi Shinohara, Eric K Hong, Bethany Horton, Youn H Kim
This pathology PILOT study aims to define the role and feasibility of centralized pathology review in a cohort of 75 patients from different centers in the United States and Europe using digital slide scanning. The pathologic material from 75 patients who had been diagnosed with mycosis fungoides/Sézary syndrome and were clinically staged as IIb or above was retrieved from 11 participating centers. Each pathology reviewer was provided with the pathologic diagnosis (by the referring pathologist), and the following list of histopathologic criteria (presence or absence) from the initial report: epidermotropism, folliculotropism (FT), large cell transformation, syringotropism, and granulomas...
March 14, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29533478/phototherapy-as-a-first-line-treatment-for-early-stage-mycosis-fungoides-the-results-of-a-large-retrospective-analysis
#15
V Nikolaou, A Sachlas, E Papadavid, A Economidi, K Karambidou, L Marinos, A Stratigos, C Antoniou
BACKGROUND: Phototherapy is one of the main treatments for mycosis fungoides (MF). In this study, we analyzed the efficacy and safety of phototherapy as a first line treatment in patients with early stage disease. METHODS: We analyzed treatment outcomes in a group of 227 early stage patients. The chi-squared test, the parametric t-test and ANOVA test and the non-parametric tests of Mann-Whitney and Kruskal-Wallis were applied for data analysis. RESULTS: 55...
March 13, 2018: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29515406/successful-treatment-of-erythrodermic-mycosis-fungoides-with-mogamulizumab-followed-by-etoposide-monotherapy
#16
Taku Fujimura, Kayo Tanita, Yota Sato, Yumi Kambayashi, Sadanori Furudate, Akira Tsukada, Akira Hashimoto, Setsuya Aiba
Mogamulizumab induces cytotoxicity against CCR4+ lymphoma cells by antibody-dependent cell-mediated cytotoxicity in advanced cutaneous T-cell lymphoma patients. Since the efficacy of mogamulizumab in mycosis fungoides (28.6%) is lower than that in Sézary syndrome (47.1%), reagents that enhance the antitumor immune response induced by mogamulizumab are needed to further optimize its use for the treatment of erythrodermic mycosis fungoides. In this report, we present a case of erythrodermic mycosis fungoides successfully treated with mogamulizumab followed by etoposide monotherapy...
January 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29515392/large-cell-transformed-mycosis-fungoides-coexisting-with-mycosis-fungoides-bullosa-a-case-report-and-review-of-the-literature
#17
Saneerat Porntharukcharoen, Suthinee Rutnin, Natta Rajatanavin
Mycosis fungoides is the most common form of cutaneous T-cell lymphoma. Both large-cell transformed mycosis fungoides and mycosis fungoides bullosa are rare presentations and predict unfavorable prognosis. We report the case of a 61-year-old woman who presented with generalized erythematous scaly annular plaques, and histopathology confirmed the diagnosis of mycosis fungoides. She was treated with various conventional therapies but only achieved partial response and always relapsed after discontinuation of treatment...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29512830/tumor-stage-mycosis-fungoides-in-palmoplantar-localization-with-large-cell-transformation-and-partial-cd30-expression-shows-complete-response-to-brentuximab-vedotin
#18
A Khoa Pham, Joi B Carter, Nora R Ratcliffe, Alexander D Fuld, Frederick Lansigan, Nancy J Burnside, Marshall A Guill, Kathryn A Zug, Lesley A Jarvis, Robert E LeBlanc
Mycosis fungoides in palmoplantar localization (MFPP) is a rare variant of MF that is confined to the hands and feet. Patients commonly receive treatment over many years for suspected palmoplantar dermatitis before the diagnosis is made. Most MFPP patients remain at patch or plaque stage, and often respond to treatment with radiotherapy. Herein we describe a 77-year-old man who suffered 6 years of hand and foot dermatitis that failed multiple treatments, most notably TNF-α inhibitors and mycophenolate mofetil...
March 7, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29511289/novel-phosphorylated-tak1-species-with-functional-impact-on-nf-%C3%AE%C2%BAb-and-%C3%AE-catenin-signaling-in-human-cutaneous-t-cell-lymphoma
#19
Fernando Gallardo, Joan Bertran, Erika López-Arribillaga, Jéssica González, Silvia Menéndez, Ignacio Sánchez, Luis Colomo, Mar Iglesias, Marta Garrido, Luis Francisco Santamaría-Babí, Ferran Torres, Ramon M Pujol, Anna Bigas, Lluís Espinosa
Cutaneous T-cell lymphomas (CTCLs) represent different subtypes of lymphoproliferative disorders with no curative therapies for the advanced forms of the disease (namely mycosis fungoides and the leukemic variant, Sézary syndrome). Molecular events leading to CTCL progression are heterogeneous, however recent DNA and RNA sequencing studies highlighted the importance of NF-κB and β-catenin pathways. We here show that the kinase TAK1, known as essential in B-cell lymphoma, is constitutively activated in CTCL cells, but tempered by the MYPT1/PP1 phosphatase complex...
February 22, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29501832/hyperpigmentation-and-higher-incidence-of-cutaneous-malignancies-in-moderate-high-pcb-and-dioxin-exposed-individuals
#20
Marike M Leijs, André Esser, Philipp M Amann, Thomas Schettgen, Monika Gube, Hans F Merk, Thomas Kraus, Jens M Baron
Polychlorinated biphenyls (PCB) are well known persistent and toxic environmental pollutants. Our aim was to identify effects of moderate-high exposure to dioxin-like (dl) and non-dioxin-like (ndl)-PCBs on the skin in order to provide more insight in the pathophysiological effects of these compounds. We performed a dermatological examination on 92 former workers from a transformer recycling company with known elevated serum PCB and/or dioxin (polychlorinated dibenzo-p-dioxin/polychlorinated dibenzo-p-furan (PCDD/F)) levels...
March 1, 2018: Environmental Research
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