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https://www.readbyqxmd.com/read/29470459/prevalence-of-self-reported-hypertension-and-antihypertensive-medication-use-among-adults-aged-%C3%A2-18-years-united-states-2011-2015
#1
Jing Fang, Cathleen Gillespie, Carma Ayala, Fleetwood Loustalot
Hypertension, which affects nearly one third of adults in the United States, is a major risk factor for heart disease and stroke (1), and only approximately half of those with hypertension have their hypertension under control (2). The prevalence of hypertension is highest among non-Hispanic blacks, whereas the prevalence of antihypertensive medication use is lowest among Hispanics (1). Geographic variations have also been identified: a recent report indicated that the Southern region of the United States had the highest prevalence of hypertension as well as the highest prevalence of medication use (3)...
February 23, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29467674/an-improved-dynamic-model-for-the-respiratory-response-to-exercise
#2
Leidy Y Serna, Miguel A Mañanas, Alher M Hernández, Roberto A Rabinovich
Respiratory system modeling has been extensively studied in steady-state conditions to simulate sleep disorders, to predict its behavior under ventilatory diseases or stimuli and to simulate its interaction with mechanical ventilation. Nevertheless, the studies focused on the instantaneous response are limited, which restricts its application in clinical practice. The aim of this study is double: firstly, to analyze both dynamic and static responses of two known respiratory models under exercise stimuli by using an incremental exercise stimulus sequence (to analyze the model responses when step inputs are applied) and experimental data (to assess prediction capability of each model)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29467616/molecular-characterization-of-gaba-a-receptor-subunit-diversity-within-major-peripheral-organs-and-their-plasticity-in-response-to-early-life-psychosocial-stress
#3
Ethan A Everington, Adina G Gibbard, Jerome D Swinny, Mohsen Seifi
Gamma aminobutyric acid (GABA) subtype A receptors (GABAA Rs) are integral membrane ion channels composed of five individual proteins or subunits. Up to 19 different GABAA R subunits (α1-6, β1-3, γ1-3, δ, ε, θ, π, and ρ1-3) have been identified, resulting in anatomically, physiologically, and pharmacologically distinct multiple receptor subtypes, and therefore GABA-mediated inhibition, across the central nervous system (CNS). Additionally, GABAA R-modulating drugs are important tools in clinical medicine, although their use is limited by adverse effects...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29466885/intralesional-therapy-as-a-treatment-for-locoregionally-metastatic-melanoma
#4
John T Miura, Jonathan S Zager
The emergence of novel intralesional therapies have dramatically changed the treatment landscape for melanoma. The heterogeneous presentation of melanoma continues to pose challenges for clinicians, especially when dealing with advanced locoregional disease. Intralesional therapies have the benefit of causing local tumor destruction, while minimizing systemic toxicity. Moreover, the integration of immunotherapeutic agents into intralesional compounds has resulted in the additional benefit of a bystander effect, whereby untreated distant lesions also derive a benefit from treatment...
February 21, 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29466041/histologic-investigation-of-airway-inflammation-in-postmortem-lung-samples-from-racehorses
#5
Fe Ter Woort, Jeff L Caswell, Luis G Arroyo, Laurent Viel
OBJECTIVE To describe histologic findings in the small airways during postmortem examination of actively racing horses and to quantify the degree of airway inflammation by use of a semiquantitative scoring system. SAMPLE Lung tissues obtained from 95 horses (Thoroughbreds, Standardbreds, and Quarter Horses) that had been actively racing or training. PROCEDURES 10 standardized lung sections were obtained during postmortem examination of 37 horses that had been actively racing or training, and 2 histologic sections of the caudodorsal lung lobes previously collected from each of 58 horses that died or were euthanized during racing or training were also obtained...
March 2018: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29465821/quantitative-magnetic-resonance-spectroscopy-at-3t-based-on-the-principle-of-reciprocity
#6
Niklaus Zoelch, Andreas Hock, Anke Henning
Quantification of magnetic resonance spectroscopy signals using the phantom replacement method requires an adequate correction of differences between the acquisition of the reference signal in the phantom and the measurement in vivo. Applying the principle of reciprocity, sensitivity differences can be corrected at low field strength by measuring the RF transmitter gain needed to obtain a certain flip angle in the measured volume. However, at higher field strength the transmit sensitivity may vary from the reception sensitivity, which leads to wrongly estimated concentrations...
February 21, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29465650/chlamydia-prevalence-trends-among-women-and-men-entering-the-national-job-training-program-from-1990-through-2012
#7
Emily R Learner, Elizabeth A Torrone, Jason P Fine, Brian W Pence, Kimberly A Powers, William C Miller
BACKGROUND: Evaluating chlamydia prevalence trends from sentinel surveillance is important for understanding population disease burden over time. However, prevalence trend estimates from surveillance data may be misleading if they do not account for changes in risk profiles of individuals who are screened (case mix) and changing performance of the screening tests used. METHODS: We analyzed chlamydia screening data from a sentinel surveillance population of 389,555 young women (1990-2012) and 303,699 young men (2003-2012) entering the US National Job Training Program...
January 26, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29465592/urinary-metalloproteinases-and-tissue-inhibitors-of-metalloproteinases-as-potential-early-biomarkers-for-renal-fibrosis-in-children-with-nephrotic-syndrome
#8
Beata Bieniaś, Przemysław Sikora
In chronic glomerulopathies, renal fibrosis (RF) results from extracellular matrix remodeling processes regulated by matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP). We assessed urinary (u-) and serum (s-) MMP-1, -2, -9, TIMP-1, -2 concentrations and MMP-1, -2, -9/TIMP-1, -2 ratios in children with nephrotic syndrome. Steroid-dependent and steroid-resistant nephrotic patients (SDNS-Ps and SRNS-Ps, respectively) were compared with respect to measured parameters. The correlations of measured parameters with magnitude of proteinuria and histopathological diagnosis were determined...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29465446/current-practices-and-attitudes-regarding-use-of-inhaled-nitric-oxide-in-the-nicu-results-from-a-survey-of-members-of-the-national-association-of-neonatal-nurse-practitioners
#9
Allyson Kayton, Paula Timoney, Lyn Vargo, Jose A Perez
BACKGROUND: Excessive supplemental oxygen exposure in the neonatal intensive care unit (NICU) can be associated with oxygen-related toxicities, which can lead to negative clinical consequences. Use of inhaled nitric oxide (iNO) can be a successful strategy for avoiding hyperoxia in the NICU. iNO selectively produces pulmonary vasodilation and has been shown to improve oxygenation parameters across the spectrum of disease severity, from mild to very severe, in neonates with hypoxic respiratory failure associated with persistent pulmonary hypertension of the newborn...
February 20, 2018: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/29463782/endogenous-volatile-organic-compounds-in-acute-myeloid-leukemia-origins-and-potential-clinical-applications
#10
Dibyendu Dutta, Ngee S Chong, Seah H Lim
Not unlike many cancer types, acute myeloid leukemia (AML) exhibits many metabolic changes and reprogramming, causing changes in lipid metabolism. Some of the distinct molecular abnormalities associated with AML also modify the metabolic changes. Both processes result in changes in the production of endogenous volatile organic compounds (VOCs). The increasing availability of highly sensitive methods for detecting trace chemicals provides the opportunity to investigate the role of patient-specific VOC finger-prints as biomarkers for detecting early relapse or minimal residual disease (MRD) in AML...
February 21, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29462597/validity-and-reliability-of-outcome-measures-assessing-dexterity-coordination-and-upper-limb-strength-in-autosomal-recessive-spastic-ataxia-of-charlevoix-saguenay
#11
Cynthia Gagnon, Isabelle Lessard, Bernard Brais, Isabelle Côté, Caroline Lavoie, Matthis Synofzik, Jean Mathieu
OBJECTIVE: To document in adults affected by Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) the intra- and interrater reliability, standard error of measurement, agreement, minimal detectable change and construct validity of the Nine-Hole Peg Test (NHPT), Standardized Finger-to-Nose Test (SFNT), and grip strength. DESIGN: Metrological study. SETTING: Neuromuscular rehabilitation clinic. PARTICIPANTS: Genetically confirmed adult patients with ARSACS (n = 42, 21 females, mean age = 38...
February 17, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29461224/-microecological-changes-in-the-intestine-and-its-effect-on-the-condition-of-hard-tissues-of-teeth-in-adolescence
#12
T Shishniashvili, T Suladze, M Makhviladze, M Pkhaladze
On the background of microecological changes in the gastrointestinal tract, mineral and protein metabolism is disrupted, biochemical changes occur in the phosphorus-calcium metabolism in the bones of the skeleton and hard tissues of the teeth. The aim of the research was to study the activity of the caries process, characterized by progressive decalcification, under conditions of microecological changes in the intestine and its effect on the processes of endogenous calcium assimilation in adolescence. Within the frames of the research 68 adolescents aged 11 to 17 years with various degrees of pathology of the gastrointestinal tract were examined...
January 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29461171/new-model-of-proliferative-vitreoretinopathy-in-rabbit-for-drug-delivery-and-pharmacodynamic-studies
#13
Sang Woong Moon, Yaoyao Sun, David Warther, Kristyn Huffman, William R Freeman, Michael J Sailor, Lingyun Cheng
Blinding retinal diseases become more epidemic as the population ages. These diseases, such as diabetic retinopathy and macular edema, are of chronic nature and require protracted drug presence at the disease site. A sustained intravitreal porous silicon delivery system with dexamethasone (pSiO2 -COO-DEX) was evaluated in a new rabbit model of proliferative vitreoretinopathy (PVR) in a real treatment design. In contrast to the pretreatment design model, pSiO2 -COO-DEX was intravitreally injected into the eyes with active inflammation...
January 1, 2018: Drug Delivery
https://www.readbyqxmd.com/read/29456219/descriptive-analysis-of-glomerulonephritis-by-histological-type-and-their-progression-among-adults-in-a-tertiary-care-center-in-sri-lanka
#14
Kawmadi W Gunawardena, Eranga S Wijewickrama, Carukshi Arambepola, Rushika D Lanerolle
Prevalence of different glomerulonephritides and their clinical course vary geographically. Our objectives are to assess the prevalence of different histological types of glomerulonephritis (GN) based on the light microscopic histology and to assess their progression according to histological type. A retrospective cross-sectional study was carried out among adult patients (>18 years) with a histological diagnosis of GN at the University Professorial Unit over a period of six months. Information including demographic data, renal biopsy findings, and progression of the disease through serum creatinine (SCr) level were collected through existing clinic records of consenting patients...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29454932/preserved-canonicality-of-the-bold-hemodynamic-response-reflects-healthy-cognition-insights-into-the-healthy-brain-through-the-window-of-multiple-sclerosis
#15
REVIEW
Monroe P Turner, Nicholas A Hubbard, Dinesh K Sivakolundu, Lyndahl M Himes, Joanna L Hutchison, John Hart, Jeffrey Spence, Elliot Frohman, Teresa Frohman, Darin Okuda, Bart Rypma
The hemodynamic response function (HRF), a model of brain blood-flow changes in response to neural activity, reflects communication between neurons and the vasculature that supplies these neurons in part by means of glial cell intermediaries (e.g., astrocytes). Intact neural-vascular communication might play a central role in optimal cognitive performance. This hypothesis can be tested by comparing healthy individuals to those with known white-matter damage and impaired performance, as seen in Multiple Sclerosis (MS)...
February 15, 2018: NeuroImage
https://www.readbyqxmd.com/read/29454006/predicting-cognitive-decline-with-deep-learning-of-brain-metabolism-and-amyloid-imaging
#16
Hongyoon Choi, Kyong Hwan Jin
For effective treatment of Alzheimer's disease (AD), it is important to identify subjects who are most likely to exhibit rapid cognitive decline. We aimed to develop an automatic image interpretation system based on a deep convolutional neural network (CNN) which can accurately predict future cognitive decline in mild cognitive impairment (MCI) patients using flurodeoxyglucose and florbetapir positron emission tomography (PET). PET images of 139 patients with AD, 171 patients with MCI and 182 normal subjects obtained from Alzheimer's Disease Neuroimaging Initiative database were used...
February 14, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29453464/dietitian-led-lifestyle-modification-programme-for-obese-chinese-adolescents-with-non-alcoholic-fatty-liver-disease-a-randomized-controlled-study
#17
D F Y Chan, H K So, S C N Hui, R S M Chan, A M Li, M M Sea, W C W Chu, M Chan, J Woo, E A S Nelson
BACKGROUND: The prevalence of non-alcoholic fatty liver disease (NAFLD) in children is increasing. This study evaluated the efficacy of a dietitian-led lifestyle modification programme (D-LMP) to reduce NAFLD in obese adolescents. METHODS: Subjects with intra-hepatic triglyceride content (IHTC) equal to or greater than 5% diagnosed by proton-magnetic resonance spectroscopy ( 1 H-MRS) were enroled and randomly assigned to either the D-LMP intervention or conventional paediatrician-led consultation (P-CON) group...
January 30, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29451950/intrinsic-changes-of-left-ventricular-function-in-patients-with-beh%C3%A3-et-disease-and-comparison-according-to-systemic-disease-activity
#18
Byung Joo Sun, Jae-Hyeong Park, Su-Jin Yoo, Yunseon Park, Yeon Ju Kim, In Suk Lee, Jinhyun Kim, In Seol Yoo, Seung Cheol Shim, Seong Wook Kang, Jun-Hyung Kim, Jae-Hwan Lee, Si Wan Choi, Jin-Ok Jeong, In-Whan Seong
PURPOSE: Although cardiac manifestation of Behçet disease (BD) has been described in sporadic reports, its timely diagnosis remains difficult. The objective of this study was to describe early cardiac manifestations of BD. We also performed a comprehensive classification of systemic BD activity and compared their cardiac manifestations. METHODS: A prospective screening using speckle tracking echocardiography was performed in 85 patients with BD who had no history of heart disease...
February 16, 2018: Echocardiography
https://www.readbyqxmd.com/read/29449506/whole-body-magnetic-resonance-imaging-in-axial-spondyloarthritis-reduction-of-sacroiliac-spinal-and-entheseal-inflammation-in-a-placebo-controlled-trial-of-adalimumab
#19
Simon Krabbe, Mikkel Østergaard, Iris Eshed, Inge J Sørensen, Bente Jensen, Jakob M Møller, Lone Balding, Ole R Madsen, Karsten Asmussen, Grith Eng, Niklas R Jørgensen, Susanne J Pedersen
OBJECTIVE: To investigate whether adalimumab (ADA) reduces whole-body (WB-) magnetic resonance imaging (MRI) indices for inflammation in the entheses, peripheral joints, sacroiliac joints, spine, and the entire body in patients with axial spondyloarthritis (axSpA). METHODS: An investigator-initiated, randomized, placebo-controlled, double-blinded 48-week followup trial included 49 patients with axSpA, who had Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) ≥ 4...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29448244/mir-499-ameliorates-podocyte-injury-by-targeting-calcineurin-in-minimal-change-disease
#20
Kaiyue Zhang, Wenjuan Sun, Lai Zhang, Xuefang Xu, Jidong Wang, Yan Hong
BACKGROUND: Podocyte injury is a hallmark of minimal change disease (MCD). Calcineurin inhibitors have been widely used in the current treatment of MCD, and miR-499 may target calcineurin. We aimed to study the function of miR-499 in MCD and test whether miR-499 delivery can improve MCD. METHODS: An MCD mouse model was generated using puromycin aminonucleoside (PAN). MiR-499 was delivered using lentiviruses. Biochemical indicators including serum albumin, triglyceride, cholesterol, and 24-h urine protein were determined...
February 15, 2018: American Journal of Nephrology
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