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minimal change disease

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https://www.readbyqxmd.com/read/29691899/droplet-digital-pcr-for-bcr-abl-p210-detecting-of-cml-a-high-sensitive-method-of-the-minimal-residual-disease-disease-progression
#1
Wen-Jun Wang, Chao-Feng Zheng, Zhuang Liu, Yan-Hong Tan, Xiu-Hua Chen, Bin-Liang Zhao, Guo-Xia Li, Zhi-Fang Xu, Fang-Gang Ren, Yao-Fang Zhang, Jian-Mei Chang, Hong-Wei Wang
OBJECTIVE: The present study intended to establish a droplet digital PCR (dd-PCR) for monitoring minimal residual disease (MRD) in patients with BCR/ABL (P210)-positive CML, thereby achieving deep-level monitoring of tumor load and determining the efficacy for guided clinically individualized treatment. METHODS: Using dd-PCR and RT-qPCR, two cell suspensions were obtained from K562 cells and normal peripheral blood mononuclear cells by gradient dilution and were measured at the cellular level...
April 25, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29691425/metabolomics-reveals-perturbations-in-endometrium-and-serum-of-minimal-and-mild-endometriosis
#2
Mainak Dutta, Brajesh Singh, Mamata Joshi, Debanjan Das, Elavarasan Subramani, Meenu Maan, Saikat Kumar Jana, Uma Sharma, Soumen Das, Swagata Dasgupta, Chaitali Datta Ray, Baidyanath Chakravarty, Koel Chaudhury
Endometriosis is a common benign gynecological disease, characterized by growth and proliferation of endometrial glands and stroma outside the uterus. With studies showing metabolic changes in various biofluids of endometriosis women, we have set upon to investigate whether endometrial tissue show differences in their metabolic profiles. 1 H NMR analysis was performed on eutopic endometrial tissue of women with endometriosis and controls. Analysis was performed on spectral data and on relative concentrations of metabolites obtained from spectra using multivariate and univariate data analysis...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29689125/directed-solutions-to-address-differences-in-access-to-liver-transplantation
#3
Fei Ye, Quanhu Sheng, Irene D Feurer, Zhiguo Zhao, Run Fan, Jing Teng, Jie Ping, Scott A Rega, Douglas W Hanto, Yu Shyr, Seth J Karp
The United Network for Organ Sharing recently altered current liver allocation with the goal of decreasing Model for End-stage Liver Disease (MELD) variance at transplant. Concerns over these and further planned revisions to policy include predicted decrease in total transplants, increased flying and logistical complexity, adverse impact on areas with poor quality health care, and minimal effect on high MELD Donor Service Areas (DSAs). To address these issues, we describe general approaches to equalize critical transplant metrics among regions and determine how they alter MELD variance at transplant and organ supply to underserved communities...
April 24, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29688306/emudra-ensemble-of-multiple-drug-repositioning-approaches-to-improve-prediction-accuracy
#4
Xianxiao Zhou, Minghui Wang, Igor Katsyv, Hanna Irie, Bin Zhang
Motivation: Availability of large-scale genomic, epigenetic and proteomic data in complex diseases makes it possible to objectively and comprehensively identify therapeutic targets that can lead to new therapies. The Connectivity Map has been widely used to explore novel indications of existing drugs. However, the prediction accuracy of the existing methods, such as Kolmogorov-Smirnov statistic remains low. Here we present a novel high-performance drug repositioning approach that improves over the state-of-the-art methods...
April 24, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29688127/the-feasibility-of-a-randomised-controlled-trial-to-compare-the-cost-effectiveness-of-palliative-cardiology-or-usual-care-in-people-with-advanced-heart-failure-two-exploratory-prospective-cohorts
#5
Miriam J Johnson, Paula McSkimming, Alex McConnachie, Claudia Geue, Yvonne Millerick, Andrew Briggs, Karen Hogg
BACKGROUND: The effectiveness of cardiology-led palliative care is unknown; we have insufficient information to conduct a full trial. AIM: To assess the feasibility (recruitment/retention, data quality, variability/sample size estimation, safety) of a clinical trial of palliative cardiology effectiveness. DESIGN: Non-randomised feasibility. SETTING/PARTICIPANTS: Unmatched symptomatic heart failure patients on optimal cardiac treatment from (1) cardiology-led palliative service (caring together group) and (2) heart failure liaison service (usual care group)...
April 1, 2018: Palliative Medicine
https://www.readbyqxmd.com/read/29686110/-tas2r38-predisposition-to-bitter-taste-associated-with-differential-changes-in-vegetable-intake-in-response-to-a-community-based-dietary-intervention
#6
Larissa Calancie, Thomas C Keyserling, Lindsey Smith Taillie, Kimberly Robasky, Cam Patterson, Alice S Ammerman, Jonathan C Schisler
Although vegetable consumption associates with decreased risk for a variety of diseases, few Americans meet dietary recommendations for vegetable intake. TAS2R38 encodes a taste receptor that confers bitter taste sensing from chemicals found in some vegetables. Common polymorphisms in TAS2R38 lead to coding substitutions that alter receptor function and result in the loss of bitter taste perception. Our study examined whether bitter taste perception TAS2R38 diplotypes associated with vegetable consumption in participants enrolled in either an enhanced or a minimal nutrition counseling intervention...
April 23, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29685715/a-small-change-can-make-a-big-difference-a-lesson-from-evolocumab
#7
Sam Mirzaee, Paul M Thein, Dennis Wong, Arthur Nasis
BACKGROUND: Evolocumab is an expensive proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor which has been shown to significantly improve cardiovascular outcomes in high risk patients. METHODS: This is a case study describing a stepwise approach to "PCSK9 inhibitor non-response" in a patient with familial hypercholesterolaemia. There are a few described pathophysiological mechanisms for "PCSK9 inhibitor non-response" including homozygous LDL-C receptor-negative mutations and alteration in the binding site of PCSK9 inhibitors...
March 20, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29682437/adult-onset-minimal-change-disease-with-iga-nephropathy-and-hepatitis-c
#8
Waliul Chowdhury, Tahira Sabeen Saleem, Muhammad Uzair Lodhi, Intekhab Askari Syed, Hafiz Imran Iqbal, Mustafa Rahim
Minimal change disease (MCD) is one of the most common causes of nephrotic syndrome in children, leading to heavy proteinuria and edema. However, it is not as common in adults. Adult-onset minimal change disease with IgA nephropathy is rare. The initial presentation of heavy proteinuria and edema with effacement of podocytes on electron microscopy (EM) should lead the physician to suspect minimal change disease regardless of age. We present a 44-year-old male patient with a history of hepatitis C virus (HCV) who presented with sudden onset of lower extremity edema and 6...
February 19, 2018: Curēus
https://www.readbyqxmd.com/read/29680873/pediatric-nephrolithiasis-a-systematic-approach-from-diagnosis-to-treatment
#9
REVIEW
Giuseppina Marra, Francesca Taroni, Alfredo Berrettini, Emanuele Montanari, Gianantonio Manzoni, Giovanni Montini
Nephrolithiasis is a rare disease in children. For many years children with kidney stones have been managed like "small adults", but there are significant differences between the pediatric and the adult age in clinical presentation, etiology and treatment. Management of this condition in children has some peculiarities with respect to the adult, as it is often the sign of an underlying metabolic abnormality. Some of these metabolic alterations can lead to serious consequences, such as chronic renal failure, if not adequately diagnosed and treated...
April 21, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29680749/syntheses-and-structure-activity-relationships-on-antibacterial-and-anti-ulcerative-colitis-properties-of-quaternary-13-substituted-palmatines-and-8-oxo-13-substituted-dihydropalmatines
#10
Li Song, Hai-Jing Zhang, An-Jun Deng, Jia Li, Xiang Li, Zhi-Hong Li, Zhi-Hui Zhang, Lian-Qiu Wu, Sheng-Qi Wang, Hai-Lin Qin
In this study, quaternary palmatine is used as a lead compound to design and synthesize derivatives to evaluate bioactivities, with twenty-seven compounds of four series being obtained. Antibacterial activity was examined by determining the minimal inhibitory concentration (MIC) values on Staphylococcus aureus, Escherichia coli, and Candida albicans, three series of derivatives being found to exhibit activity in vitro with significant structure-activity relationship (SAR). Elongating the carbon chain led to the antibacterial activity increased, with quaternary 13-hexanoylpalmatine chloride, quaternary 13-(ω-ethoxycarbonyl)heptylpalmatine chloride, and 8-oxo-13-(N-n-nonyl)aminomethyldihydropalmatine, all of which possess the longest aliphatic carbon chain in the corresponding series of derivatives, showing the MIC values of 62...
April 11, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29679917/possible-impacts-of-sea-level-rise-on-disease-transmission-and-potential-adaptation-strategies-a-review
#11
REVIEW
Ana C Dvorak, Helena M Solo-Gabriele, Andrea Galletti, Bernardo Benzecry, Hannah Malone, Vicki Boguszewski, Jason Bird
Sea levels are projected to rise in response to climate change, causing the intrusion of sea water into land. In flat coastal regions, this would generate an increase in shallow water covered areas with limited circulation. This scenario raises a concern about the consequences it could have on human health, specifically the possible impacts on disease transmission. In this review paper we identified three categories of diseases which are associated with water and whose transmission can be affected by sea level rise...
April 18, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29679356/regional-variations-in-immunosuppressive-therapy-in-patients-with-primary-nephrotic-syndrome-the-japan-nephrotic-syndrome-cohort-study
#12
Ryohei Yamamoto, Enyu Imai, Shoichi Maruyama, Hitoshi Yokoyama, Hitoshi Sugiyama, Kosaku Nitta, Tatsuo Tsukamoto, Shunya Uchida, Asami Takeda, Toshinobu Sato, Takashi Wada, Hiroki Hayashi, Yasuhiro Akai, Megumu Fukunaga, Kazuhiko Tsuruya, Kosuke Masutani, Tsuneo Konta, Tatsuya Shoji, Takeyuki Hiramatsu, Shunsuke Goto, Hirofumi Tamai, Saori Nishio, Arimasa Shirasaki, Kojiro Nagai, Kunihiro Yamagata, Hajime Hasegawa, Hidemo Yasuda, Shizunori Ichida, Tomohiko Naruse, Kei Fukami, Tomoya Nishino, Hiroshi Sobajima, Satoshi Tanaka, Toshiyuki Akahori, Takafumi Ito, Terada Yoshio, Ritsuko Katafuchi, Shouichi Fujimoto, Hirokazu Okada, Eiji Ishimura, Junichiro James Kazama, Keiju Hiromura, Tetsushi Mimura, Satashi Suzuki, Yosuke Saka, Tadashi Sofue, Yusuke Suzuki, Yugo Shibagaki, Kiyoki Kitagawa, Kunio Morozumi, Yoshiro Fujita, Makoto Mizutani, Takashi Shigematsu, Naoki Kashihara, Hiroshi Sato, Seiichi Matsuo, Ichiei Narita, Yoshitaka Isaka
BACKGROUND: The lack of high-quality clinical evidences hindered broad consensus on optimal therapies for primary nephrotic syndromes. The aim of the present study was to compare prevalence of immunosuppressive drug use in patients with primary nephrotic syndrome across 6 regions in Japan. METHODS: Between 2009 and 2010, 380 patients with primary nephrotic syndrome in 56 hospitals were enrolled in a prospective cohort study [Japan Nephrotic Syndrome Cohort Study (JNSCS)], including 141, 151, and 38 adult patients with minimal change disease (MCD), membranous nephropathy (MN), and focal segmental glomerulosclerosis (FSGS), respectively...
April 20, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29679099/radiation-induced-carotid-artery-lesions
#13
REVIEW
Verónica Fernández-Alvarez, Fernando López, Carlos Suárez, Primoz Strojan, Avraham Eisbruch, Carl E Silver, William M Mendenhall, Johannes A Langendijk, Alessandra Rinaldo, Anne W M Lee, Jonathan J Beitler, Robert Smee, Javier Alvarez, Alfio Ferlito
PURPOSE: To review the current aspects of knowledge related to the risk of cerebrovascular events in patients receiving head and neck radiotherapy. METHODS: A literature search was performed in PubMed. Papers meeting selection criteria were reviewed. RESULTS: We provide an update on the problem by identifying key studies that have contributed to our current understanding of the epidemiology, radiologic features, pathogenesis, and treatment of the disease...
April 20, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29676049/moderate-weight-loss-improves-body-composition-and-metabolic-function-in-metabolically-unhealthy-lean-subjects
#14
Yu Chung Chooi, Cherlyn Ding, Zhiling Chan, John Choo, Suresh Anand Sadananthan, Navin Michael, Yijun Lee, S Sendhil Velan, Faidon Magkos
OBJECTIVE: Individuals who have "metabolically obese normal weight" (MONW) have an increased risk for cardiometabolic disease. Moderate weight loss has multiple benefits in people with obesity, but its effects in lean people are unknown. Thus, the effects of diet-induced 5% weight loss on body composition and metabolic function in MONW subjects were evaluated. METHODS: Total body fat, visceral adipose tissue (VAT) and subcutaneous abdominal adipose tissue (SAT) volumes, intrahepatic and intramyocellular lipid contents, insulin sensitivity (hyperinsulinemic-euglycemic clamp), glucose tolerance, and postprandial insulin secretion and clearance rates (mixed meal with minimal modeling) were measured before and after 4...
April 19, 2018: Obesity
https://www.readbyqxmd.com/read/29675415/practical-and-ethical-aspects-of-advance-research-directives-for-research-on-healthy-aging-german-and-israeli-professionals-perspectives
#15
Perla Werner, Silke Schicktanz
Background: Healthy aging is the development and maintenance of optimal cognitive, social and physical well-being, and function in older adults. Preventing or minimizing disease is one of the main ways of achieving healthy aging. Dementia is one of the most prevalent and life-changing diseases of old age. Thus, dementia prevention research is defined as one of the main priorities worldwide. However, conducting research with persons who lack the capacity to give consent is a major ethical issue...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29675075/pediatric-cushing-s-disease-dichotomy-in-lateralization-between-imaging-and-inferior-petrosal-sinus-sampling-with-review-of-literature
#16
Salman Tehran Shaikh, Vikram S Karmarkar, Chandrashekhar Eknath Deopujari
Inferior petrosal sinus sampling (IPSS) is a minimally invasive method done in adrenocorticotrophic hormone (ACTH)-dependent pituitary adenoma cases where magnetic resonance imaging (MRI) either gives equivocal results or fails to localize it. A 12-year-girl with cushingoid features and raised ACTH levels presented to us with two consecutive MRI's done outside showing gross change in the morphology of a left-sided pituitary adenoma. Hence, a bilateral IPSS was done which showed a higher IPS/periphery ACTH ratio on the right side as compared to left...
October 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29674420/white-matter-reference-region-in-pet-studies-of-11-c-pittsburgh-compound-b-uptake-effects-of-age-and-amyloid-%C3%AE-deposition
#17
Val J Lowe, Emily S Lundt, Matthew L Senjem, Christopher G Schwarz, Hoon-Ki Min, Scott A Przybelski, Kejal Kantarci, David Knopman, Ronald C Petersen, Clifford R Jack
Amyloid-β (Aβ) deposition as seen on positron emission tomography (PET) using an Aβ binding agent is a critical diagnostic biomarker for Alzheimer's disease (AD). Some reports suggest using white matter (WM) as a reference region for quantification of serial Aβ PET studies; however, nonspecific WM retention in Aβ PET in people with dementia or in cognitively unimpaired (CU) has been widely reported and is poorly understood. Methods: To investigate the suitability of WM as a reference region and the factors affecting WM 11 C-Pittsburgh Compound B (PiB) uptake variability, we conducted a retrospective study on two large data sets: 1) a longitudinal study of participants ( n = 577) who were CU, had mild cognitive impairment (MCI), or had dementia likely due to AD (ADD); and 2) a cross-sectional study of single-scan PET imaging in CU subjects ( n = 1349)...
April 19, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29671663/a-note-on-improvement-in-dermatology-life-quality-index-dlqi-among-patients-with-hidradenitis-suppurativa-treated-with-adalimumab
#18
Simon Francis Thomsen
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with profound negative impact on quality of life. Adalimumab (anti-TNF) is indicated for moderate-to-severe HS unresponsive to conventional therapy. Herein, studies of the change in Dermatology Life Quality Index (DLQI) among patients with HS treated with adalimumab are reviewed. The anticipated gain in DLQI is only modest in patients with HS treated with adalimumab, even in trials of high quality, and does not exceed the established minimal clinically important difference...
April 19, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29671381/minimal-clinically-important-differences-in-treadmill-6-minute-walk-and-patient-based-outcomes-following-supervised-and-home-based-exercise-in-peripheral-artery-disease
#19
Andrew W Gardner, Polly S Montgomery, Ming Wang
We estimated minimal clinically important differences (MCIDs) for small, moderate, and large changes in measures obtained from a standardized treadmill test, a 6-minute walk test, and patient-based outcomes following supervised and home-based exercise programs in symptomatic patients with peripheral artery disease (PAD). Patients were randomized to either 12 weeks of a supervised exercise program ( n=60), a home-based exercise program ( n=60), or an attention-control group ( n=60). Using the distribution-based method to determine MCIDs, the MCIDs for small, moderate, and large changes in peak walking time (PWT) in the supervised exercise group were 38, 95, and 152 seconds, respectively, and the changes in claudication onset time (COT) were 35, 87, and 138 seconds...
April 1, 2018: Vascular Medicine
https://www.readbyqxmd.com/read/29670873/severe-urban-outdoor-air-pollution-and-children-s-structural-and-functional-brain-development-from-evidence-to-precautionary-strategic-action
#20
Amedeo D'Angiulli
According to the latest estimates, about 2 billion children around the world are exposed to severe urban outdoor air pollution. Transdisciplinary, multi-method findings from epidemiology, developmental neuroscience, psychology, and pediatrics, show detrimental outcomes associated with pre- and postnatal exposure are found at all ages. Affected brain-related functions include perceptual and sensory information processing, intellectual and cognitive development, memory and executive functions, emotion and self-regulation, and academic achievement...
2018: Frontiers in Public Health
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