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https://www.readbyqxmd.com/read/27904098/relationship-between-pk-pd-of-cefepime-and-clinical-outcome-in-febrile-neutropenic-patients-with-normal-renal-function
#1
Yoshiko Yamashita, Hidekazu Kamiyama, Asuka Yamamoto, Hiroki Kanoh, Yoshimitsu Yuhki, Akira Ueda, Yukari Kawamoto, Yoshikazu Gotoh, Satoshi Yamamoto
 The efficacy of cefepime (CFPM) is known to depend on the ratio of the time that the serum levels exceed the minimum inhibitory concentration (MIC) to the dosing interval (%T>MIC). The objective of this study was to clarify the relation between %T>MIC and clinical outcome of CFPM, and to identify the optimal dosage regimen. We investigated the outcome of CFPM treatment for febrile neutropenia (FN) patients with normal renal function. Treatment success was defined as the completion of FN therapy with CFPM only...
2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/27817239/modified-docetaxel-cisplatin-and-fluorouracil-therapy-as-the-first-line-treatment-for-patients-with-recurrent-metastatic-squamous-cell-carcinoma-of-the-head-and-neck-cancer-a-retrospective-study
#2
Nebi Serkan Demirci, Sercan Aksoy, Nuriye Yıldırım Özdemir, Gökmen Umut Erdem, Melike Ozcelik, Eda Tanrikulu, Tülay Eren, Yakup Bozkaya, Süleyman Sahin, Fatma Başol, Suheyla Aytac Aslan, Nurullah Zengin, İbrahim Güllü
AIM: Modified DCF (mDCF) therapy has been shown to be well-tolerated and highly effective regimen for metastatic gastric carcinoma. Herein we investigated the effectiveness of mDCF combination as the first-line treatment in patients with recurrent/metastatic squamous cell carcinoma of the head and neck cancer (HNSCC). METHODS: A total of 80 patients with recurrent/metastatic HNSCC who were treated with mDCF between 2009 and 2015 were enrolled into this study. All patients were treated as the first-line with 2-6 cycles of mDCF chemotherapy which consisted of docetaxel 60 mg/m(2) intravenously (IV) on day 1, cisplatin 60 mg/m(2) IV on day 1, and 5-fluorouracil 600 mg/m(2) IV for 5 days of continuous infusion, with cycles repeated every 21 days...
November 5, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27793737/benzylpenicillin-plus-an-aminoglycoside-versus-meropenem-in-neutropenic-lymphoma-and-leukaemia-patients-with-a-suspected-bacterial-infection-a-randomized-controlled-trial
#3
Dag Torfoss, Tone Fladhagen, Harald Holte, Lorentz Brinch, Fredrik Hellem Schjesvold, Yngvar Fløisand, Emil Nyquist, Jakob Dalgaard, Peter Meyer, Anne Kristine Lehmann, Jens Hammerstrøm, Tove Skjelbakken, E Arne Høiby, Leiv Sandvik, Stein Kvaløy
OBJECTIVES: In Norway, initial treatment of febrile neutropenia (FN) has traditionally been benzylpenicillin plus an aminoglycoside (PA). Internationally, FN is often treated with a broad-spectrum β-lactam antibiotic. We aimed to compare these two regimens in a prospective, randomized, trial in lymphoma and leukaemia patients with an expected period of neutropenia ≥7days, and a suspected bacterial infection. METHODS: Adult neutropenic patients with lymphoma or leukaemia, and a suspected bacterial infection, were randomized for treatment with PA or meropenem (M)...
October 25, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27771837/bacteremia-during-neutropenic-episodes-in-children-undergoing-hematopoietic-stem-cell-transplantation-with-ciprofloxacin-and-penicillin-prophylaxis
#4
Worawut Choeyprasert, Suradej Hongeng, Usanarat Anurathapan, Samart Pakakasama
Bacteremia during neutropenic episodes is a cause of morbidity and mortality in patients undergoing hematopoietic stem cell transplantation (HSCT). We have used oral ciprofloxacin and penicillin V, from the start of the conditioning regimen until engraftment, for the prophylaxis of bacterial infection. The objective of this study was to retrospectively analyze the prevalence of and risk factors for breakthrough bacteremia during neutropenic episodes in autologous and allogeneic HSCT patients. There were 215 patients enrolled, with a median age of 8...
October 22, 2016: International Journal of Hematology
https://www.readbyqxmd.com/read/27742208/pharmacodynamic-and-pharmacokinetic-profiling-of-delafloxacin-in-a-murine-lung-model-against-community-acquired-respiratory-tract-pathogens
#5
Abrar K Thabit, Jared L Crandon, David P Nicolau
Increasing antimicrobial resistance in community-acquired pneumonia (CAP) pathogens has contributed to infection-related morbidity and mortality. Delafloxacin is a novel fluoroquinolone with broad-spectrum activity against Gram-positive and -negative organisms, including Streptococcus pneumoniae and methicillin-resistant Staphylococcus aureus (MRSA). This study aimed to define the pharmacodynamic profile of delafloxacin against CAP pathogens using a neutropenic murine lung infection model. Five S. pneumoniae, 2 methicillin-susceptible S...
September 29, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27671063/pharmacodynamics-of-ceftolozane-combined-with-tazobactam-against-enterobacteriaceae-in-a-neutropenic-mouse-thigh-model
#6
M J Melchers, E Mavridou, A C van Mil, C Lagarde, J W Mouton
Ceftolozane is a new broad-spectrum cephalosporin and is combined with tazobactam to broaden the activity of ceftolozane against strains producing extended-spectrum beta-lactamases (ESBLs). We determined the pharmacodynamics (PD) of the combination in the neutropenic mouse thigh model to determine the optimal exposure of tazobactam. Treatment of CD-1 neutropenic mice was started 2 h after infection with ceftolozane every 2 h (q2h) alone or in combination with tazobactam at different dosing frequencies for 24 h, and the number of CFU in the thighs was determined before and after treatment...
December 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27648294/phase-ii-study-of-neo-adjuvant-chemotherapy-for-locally-advanced-gastric-cancer
#7
Alex Yuang-Chi Chang, Kian Fong Foo, Wen-Hsin Koo, Simon Ong, Jimmy So, Daniel Tan, Khong Hee Lim
BACKGROUND: Neoadjuvant chemotherapy improves survival of locally advanced gastric cancer patients. However, benefit is limited and the best regimen remains controversial. OBJECTIVES: Our primary objective of this prospective, multicenter phase 2 study was to evaluate the pathological complete response rate (PCR) with 2 cycles of docetaxel and capecitabine. METHODS: To be eligible, patients had to have histologically documented gastric cancer, a ECOG performance status 0 or 1, T3or4 Nany M0 staging after oesophagogastroduodenoscopy (OGD), endoscopic ultrasound (EUS), CT scan of thorax and abdomen, and negative laparoscopic examination and peritoneal washing...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27640002/comparison-of-two-dose-levels-of-cyclophosphamide-for-successful-stem-cell-mobilization-in-myeloma-patients
#8
Nils Winkelmann, Max Desole, Inken Hilgendorf, Thomas Ernst, Herbert G Sayer, Christa Kunert, Lars-Olof Mügge, Andreas Hochhaus, Sebastian Scholl
INTRODUCTION: Even in the era of proteasome inhibitors and immunomodulatory drugs, the autologous stem cell transplantation after high-dose melphalan continues to represent a standard approach for myeloma patients in first-line therapy. Different mobilization chemotherapies before stem cell apheresis have been published while cyclophosphamide at a dose level of up to 4 g/m(2) has been evaluated and is commonly applied. In contrast, lower dose levels of cyclophosphamide (e.g., 1.5 g/m(2)) did not result in a sufficient collection of stem cells...
September 17, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27590107/a-phase-i-ii-study-of-escalating-doses-of-bortezomib-in-conjunction-with-high-dose-melphalan-as-a-conditioning-regimen-for-salvage-autologous-peripheral-blood-stem-cell-transplantation-in-patients-with-multiple-myeloma
#9
Noa Biran, Scott D Rowley, David H Vesole, Shijia Zhang, Michele L Donato, Joshua Richter, Alan P Skarbnik, Andrew Pecora, David S Siegel
Escalating doses of bortezomib with high-dose melphalan was evaluated as as a conditioning regimen for autologous stem cell transplantation (ASCT) in patients with relapsed or refractory multiple myeloma (MM). MM patients with less than a partial remission (PR) (or 50% reduction) compared to their pretransplantation paraprotein parameters after a prior ASCT with melphalan conditioning, or who were in relapse after a prior autologous transplantation, were eligible for study. Bortezomib was dose escalated in steps of 1, 1...
August 31, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27575541/phase-ii-study-of-propylene-glycol-free-melphalan-combined-with-carmustine-etoposide-and-cytarabine-for-myeloablative-conditioning-in-lymphoma-patients-undergoing-autologous-stem-cell-transplantation
#10
Amanda F Cashen, Theresa Fletcher, Connie Ceriotti, Feng Gao, Armin Ghobadi, Ravi Vij, Keith Stockerl-Goldstein, John DiPersio, Camille Abboud
The lyophilized formulation of melphalan has several limitations based on its marginal solubility, limited stability after reconstitution, and the requirement to reconstitute it in propylene glycol (PG). PG-free melphalan (Evomela; Spectrum Pharmaceuticals, Irvine CA) overcomes these limitations by using the solubilizing agent Captisol (Ligand Pharmaceuticals, Inc., LaJolla CA) to improve the stability of the reconstituted melphalan and avoid the potential toxicities of PG. This phase II study investigated the safety and efficacy of high-dose PG-free melphalan when included in the carmustine, etoposide, and cytarabine (BEAM) regimen for adult patients with non-Hodgkin lymphoma (NHL) or Hodgkin lymphoma (HL)...
August 26, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27502729/dose-dense-fec-followed-by-docetaxel-versus-docetaxel-plus-cyclophosphamide-as-adjuvant-chemotherapy-in-women-with-her2-negative-axillary-lymph-node-positive-early-breast-cancer-a-multicenter-randomized-study-by-the-hellenic-oncology-research-group-horg
#11
D Mavroudis, A Matikas, N Malamos, P Papakotoulas, S Kakolyris, I Boukovinas, A Athanasiadis, N Kentepozidis, N Ziras, P Katsaounis, E Saloustros, V Georgoulias
BACKGROUND: Sequential administration of anthracycline and taxane is the current standard of care adjuvant regimen for node-positive early breast cancer. Due to long-term toxicity concerns, anthracycline-free regimens have been developed. We compared a sequential dose-dense anthracycline and taxane regimen with the anthracycline-free regimen of docetaxel and cyclophosphamide. PATIENTS AND METHODS: In this randomized, non-inferiority, phase III trial, women with HER2-negative invasive breast cancer and at least one positive axillary lymph node were randomized to receive either epirubicin (75 mg/m(2)), 5-fluorouracil (500 mg/m(2)) and cyclophosphamide (500 mg/m(2)) every 2 weeks for four cycles, followed by four cycles of docetaxel (75 mg/m(2)) every 2 weeks with prophylactic G-CSF support (FEC → D) or docetaxel (75 mg/m(2)) and cyclophosphamide (600 mg/m(2)) every 21 days for six cycles (TC)...
October 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27470601/ciprofloxacin-versus-colistin-prophylaxis-during-neutropenia-in-acute-myeloid-leukemia-two-parallel-patient-cohorts-treated-in-a-single-center
#12
Michele Pohlen, Julia Marx, Alexander Mellmann, Karsten Becker, Rolf M Mesters, Jan-Henrik Mikesch, Christoph Schliemann, Georg Lenz, Carsten Müller-Tidow, Thomas Büchner, Utz Krug, Matthias Stelljes, Helge Karch, Georg Peters, Hans U Gerth, Dennis Görlich, Wolfgang E Berdel
Patients undergoing intensive chemotherapy for acute myeloid leukemia are at high risk for bacterial infections during therapy-related neutropenia. However, the use of specific antibiotic regimens for prophylaxis in afebrile neutropenic acute myeloid leukemia patients is controversial. We report a retrospective evaluation of 172 acute myeloid leukemia patients who received 322 courses of myelosuppressive chemotherapy and had an expected duration of neutropenia of more than seven days. The patients were allocated to antibiotic prophylaxis groups and treated with colistin or ciprofloxacin through 2 different hematologic services at our hospital, as available...
October 2016: Haematologica
https://www.readbyqxmd.com/read/27456399/response-to-docetaxel-and-cisplatin-induction-chemotherapy-of-locally-advanced-head-and-neck-squamous-cell-carcinoma-a-multicenter-non-comparative-open-label-interventional-pilot-study
#13
V Noronha, C Goswami, S Patil, A Joshi, V M Patil, V Murthy, S Arya, S Juvekar, S Goud, K Prabhash
BACKGROUND: Docetaxel, cisplatin plus 5-fluorouracil is an efficacious induction regimen but is more toxic than cisplatin plus 5-fluorouracil. This study aimed to determine whether docetaxel and cisplatin without 5-fluorouracil maintains efficacy while decreasing toxicity. METHODS: A multicenter non-comparative pilot study of locally advanced squamous cell carcinoma of the head and neck was performed. Patients received primary therapy comprising three cycles of 75 mg/m2 docetaxel and 75 mg/m2 cisplatin followed by concurrent chemoradiotherapy...
September 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27431641/-a-pancreatic-cancer-patient-in-whom-pegfilgrastim-prophylaxis-did-not-prevent-severe-neutropenia-caused-by-the-folfirinox-regimen
#14
Takayoshi Kiba, Yuko Saito, Chiaki Otomo, Miho Sato, Takayoshi Meguro
Recently, newer agents in regimens such as FOLFIRINOX have shown promising activity, being superior to gemcitabine as a single agent for unresectable pancreatic cancer patients with good performance status. Herein, we report a case of pancreatic cancer treated with the FOLFIRINOX regimen and pegfilgrastim prophylaxis as second-line treatment in a patient who failed this regimen. He previously received gemcitabine/nab-paclitaxel combination chemotherapy as first-line treatment. It was reported that grade 3-4 neutropenia frequently occurred in many patients receiving the FOLFIRINOX regimen...
July 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27378086/ncri-phase-ii-study-of-chop-in-combination-with-ofatumumab-in-induction-and-maintenance-in-newly-diagnosed-richter-syndrome
#15
Toby A Eyre, Ruth Clifford, Adrian Bloor, Lucy Boyle, Corran Roberts, Maite Cabes, Graham P Collins, Stephen Devereux, George Follows, Christopher P Fox, John Gribben, Peter Hillmen, Chris S Hatton, Tim J Littlewood, Helen McCarthy, Jim Murray, Andrew R Pettitt, Elizabeth Soilleux, Basile Stamatopoulos, Sharon B Love, Andrew Wotherspoon, Anna Schuh
Richter syndrome (RS) is associated with chemotherapy resistance and a poor historical median overall survival (OS) of 8-10 months. We conducted a phase II trial of standard CHOP-21 (cyclophosphamide, doxorubicin, vincristine, prednisolone every 21 d) with ofatumumab induction (Cycle 1: 300 mg day 1, 1000 mg day 8, 1000 mg day 15; Cycles 2-6: 1000 mg day 1) (CHOP-O) followed by 12 months ofatumumab maintenance (1000 mg given 8-weekly for up to six cycles). Forty-three patients were recruited of whom 37 were evaluable...
October 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27365524/combination-chemotherapy-with-methotrexate-and-vinblastine-for-surgically-unresectable-aggressive-fibromatosis
#16
Kyong-Hwa Park, Yoon Ji Choi, Kwan-Woo Kim, Kyung-Han Ro, Chang Ho Kang, Sang-Heon Song, Jong Hoon Park
OBJECTIVE: To elucidate the clinical benefit and safety of low-dose chemotherapy using methotrexate and vinblastine in patients (mostly adults) with progressive and/or symptomatic fibromatosis. METHODS: Patients were enrolled if they were treated with methotrexate and vinblastine chemotherapy for recurrences after surgical excision or newly diagnosed aggressive fibromatosis that was not amenable to surgical resection at the Korea University Medical Center from May 2008 to February 2016...
September 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27281087/the-clinical-outcomes-and-predictive-factors-for-in-hospital-mortality-in-non-neutropenic-patients-with-candidemia
#17
Tsai-Yu Wang, Chia-Yen Hung, Shian-Sen Shie, Pai-Chien Chou, Chih-Hsi Kuo, Fu-Tsai Chung, Yu-Lun Lo, Shu-Min Lin
Recent epidemiologic studies have showed that candidemia is an important nosocomial infection in hospitalized patients. The majority of candidemia patients were non-neutropenic rather than neutropenic status. The aim of this study was to determine the clinical outcome of non-neutropenic patients with candidemia and to measure the contributing factors for mortality. A total of 163 non-neutropenic patients with candidemia during January 2010 to December 2013 were retrospectively enrolled. The patients' risk factors for mortality, clinical outcomes, treatment regimens, and Candida species were analyzed...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27249763/issues-on-the-use-of-white-blood-cell-growth-factors-in-oncology-practice
#18
Gary H Lyman
Appropriate use of myeloid growth factors may reduce the risk of neutropenic complications including febrile neutropenia (FN) in patients receiving cancer chemotherapy. The recently updated American Society of Clinical Oncology (ASCO) Guidelines on the Use of the White Blood Cell Growth Factors recommends routine prophylaxis with these agents starting in the first cycle when the risk of FN is 20% or greater. However, the risks for neutropenic complications and the risk of serious adverse consequences from FN vary considerably with different chemotherapy regimens as well as other disease-, treatment-, and patient-specific risk factors...
2016: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/27234989/trabectedin-for-soft-tissue-sarcoma-current-status-and-future-perspectives
#19
REVIEW
Erlinda M Gordon, K Kumar Sankhala, Neal Chawla, Sant P Chawla
UNLABELLED: Trabectedin (ET743, Yondelis(®), manufactured by Baxter Oncology GmbH, Halle/Westfalen, Germany, for Janssen Products, LP, Horsham, PA), derived from the marine ascidian, Ecteinascidia turbinata, is a natural alkaloid with multiple complex mechanisms of action. On 23 October 2015, 15 years after the results of the first Phase 1 clinical trial using trabectedin for chemotherapy-resistant solid malignancies was reported, and 8 years after its approval in Europe, the United States Food and Drug Administration (USFDA) finally approved trabectedin for the treatment of unresectable or metastatic liposarcoma or leiomyosarcoma that has failed a prior anthracycline-containing regimen...
July 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27117516/mycobacterium-mucogenicum-bacteremia-in-immune-compromised-patients-2008-2013
#20
M Z Abidi, N Ledeboer, A Banerjee, P Hari
Mycobacterium mucogenicum (MM) is a rapidly growing nontuberculous mycobacterium that may rarely cause bacteremia in immune-compromised hosts. All MM cases from 2008 to 2013 were analyzed across 4 risk groups: stem cell transplantation (SCT), hematologic malignancy, solid tumors, and others. Descriptive analysis was performed, as well as comparative analysis of neutropenic patients (absolute neutrophil count ≤1000/μL) with nonneutropenic patients. Of 39 MM cases, 27 patients had undergone SCT. Neutropenia was present in 12 patients...
June 2016: Diagnostic Microbiology and Infectious Disease
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