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https://www.readbyqxmd.com/read/28446987/blunt-chest-trauma-is-there-a-place-for-rib-stabilization
#1
REVIEW
John D Mitchell
Rib fractures are a common and highly morbid finding in patients with blunt chest trauma. Over the past decade, a renewed interest in (and instrumentation for) rib fixation in this cohort has occurred. Stabilization of the chest wall in this setting, particularly when a flail segment is present, is associated with significant reductions in the rates of respiratory failure, pneumonia, ICU stay, and mortality. Thoracic surgeons should remain actively involved in this evolving area of our specialty to further optimize patient outcomes...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28446049/the-relationship-between-the-five-minute-apgar-score-mode-of-birth-and-neonatal-outcomes
#2
Harshithaa Thavarajah, Christopher Flatley, Sailesh Kumar
OBJECTIVE: To investigate the relationship between the five-minute Apgar score categories (low, intermediate, and normal), mode of birth and neonatal outcomes. METHODS: This was a retrospective cross sectional study of term singleton deliveries at Mater Mothers' Hospital in Brisbane, Australia between January 2007 and December 2015. The five minute score was subdivided in to three categories - low (0-3), intermediate (4-6), and normal (≥7). These were correlated with adverse neonatal outcomes and mode of birth...
April 26, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28445636/disposable-autonomous-device-for-rapid-swab-to-result-diagnosis-of-influenza
#3
Shichu Huang, Koji Abe, Steven Bennett, Tinny Liang, Paula D Ladd, Lindsay Yokobe, Caitlin E Anderson, Kamal Shah, Josh Bishop, Mike Purfield, Peter C Kauffman, Sai Paul, AnneMarie E Welch, Bonnie Strelitz, Kristin Follmer, Kelsey Pullar, Luis Sanchez-Erebia, Emily Gerth-Guyette, Gonzalo J Domingo, Eileen Klein, Janet A Englund, Elain Fu, Paul Yager
A prototype of a self-contained, automated, disposable device for chemically-amplified protein-based detection of influenza virus from nasal swab specimens was developed and evaluated in a clinical setting. The device required only simple specimen manipulation without any dedicated instrumentation or specialized training by the operator for interpretation. The device was based on a sandwich immunoassay for influenza virus nucleoprotein; it used an enzyme-labeled antibody and a chromogenic substrate to provide an amplified visible signal, in a two-dimensional paper network format...
April 26, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28441862/spatial-temporal-dispersion-of-aerosolized-nanoparticles-during-the-use-of-consumer-spray-products-and-estimates-of-inhalation-exposure
#4
Jihoon Park, Seunghon Ham, Miyeon Jang, Jinho Lee, Sunju Kim, Sungkyoon Kim, Kiyoung Lee, Donguk Park, Jung-Taek Kwon, Hyunmi Kim, Pilje Kim, Kyunghee Choi, Chungsik Yoon
We evaluated the spatial-temporal dispersion of airborne nanomaterials during the use of spray consumer products and estimated the level of consumer inhalation exposure. A total of eight spray products including five propellant and three pump types were selected to evaluate the dispersion of airborne nanoparticles across time and space in a cleanroom which could control the background particles. Four products were advertised to contain silver and one contained titanium nanoparticles, while three products were specified no ENM but as being manufactured through the use of nanotechnology...
April 25, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28429311/improving-animal-welfare-using-continuous-nalbuphine-infusion-in-a-long-term-rat-model-of-sepsis
#5
Victor Jeger, Mattia Arrigo, Florian F Hildenbrand, Daniel Müller, Paulin Jirkof, Till Hauffe, Burkhardt Seifert, Margarete Arras, Donat R Spahn, Dominique Bettex, Alain Rudiger
BACKGROUND: Sepsis research relies on animal models to investigate the mechanisms of the dysregulated host response to infection. Animal welfare concerns request the use of potent analgesics for the Refinement of existing sepsis models, according to the 3Rs principle. Nevertheless, adequate analgesia is often missing, partly because the effects of analgesics in this particular condition are unknown. We evaluated the use of nalbuphine, an opioid with kappa agonistic and mu antagonistic effects, in rats with and without experimental sepsis...
December 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28427547/qualitative-evaluation-of-the-st-george-s-respiratory-questionnaire-in-patients-with-severe-asthma
#6
Linda M Nelsen, Miriam Kimel, Lindsey T Murray, Hector Ortega, Sarah M Cockle, Steven W Yancey, Guy Brusselle, Frank C Albers, Paul W Jones
PURPOSE: Content validity is the extent to which a patient-reported outcome measure evaluates the concepts most relevant to a patient's condition and treatment. The St George's Respiratory Questionnaire (SGRQ) has been validated in a range of respiratory conditions. This study evaluated the content validity of the SGRQ in patients with severe asthma. METHODS: A qualitative study, guided by a protocol, which included concept elicitation and cognitive debriefing of the SGRQ, was conducted in patients aged ≥18 years with history of severe asthma and blood eosinophil counts of ≥150/μL (past month) or ≥300/μL (past 12 months)...
May 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28426759/health-related-quality-of-life-in-south-african-patients-with-pulmonary-tuberculosis
#7
Tanja Kastien-Hilka, Bernd Rosenkranz, Edina Sinanovic, Bryan Bennett, Matthias Schwenkglenks
BACKGROUND: The evaluation of patient-reported health-related quality of life (HRQOL) in pulmonary tuberculosis (TB) contributes to a comprehensive understanding of the burden associated with this disease. The aim of this study was to assess the overall impact of TB on the health status and on single health domains identified in the WHO definition of health, including physical, mental and social health aspects. METHODS: Four instruments for HRQOL evaluation were applied in a longitudinal multicentre study during six-month standard TB treatment in South Africa...
2017: PloS One
https://www.readbyqxmd.com/read/28419356/arousal-induced-hypocapnia-does-not-reduce-genioglossus-activity-in-obstructive-sleep-apnea-arousal-induced-hypocapnia-in-osa-muscle-effects
#8
Jennifer M Cori, Therese Thornton, Fergal J O'Donoghue, Peter D Rochford, David P White, John Trinder, Amy S Jordan
Study Objectives: To determine whether arousals that terminate obstructive events in obstructive sleep apnea (OSA): 1. Induce hypocapnia and 2. Subsequently reduce genioglossus muscle activity following the return to sleep. Methods: 31 untreated OSA patients slept instrumented with: sleep staging electrodes, nasal mask and pneumotachograph, end-tidal CO2 monitoring and intramuscular genioglossus electrodes. End-tidal CO2 was monitored and respiratory arousals were assigned an end-arousal CO2 change value (PETCO2 on the last arousal breath minus each individual's wakefulness PETCO2)...
April 13, 2017: Sleep
https://www.readbyqxmd.com/read/28417609/action-plans-and-coping-strategies-in-elderly-copd-patients-influence-the-result-of-pulmonary-rehabilitation-an-observational-study
#9
Patrizia Russo, Giulia Prinzi, Aliaksei Kisialou, Vittorio Cardaci, Emanuele Stirpe, Vittoria Conti, Massimo Fini, Stefano Bonassi
BACKGROUND: COPD management needs a comprehensive assessment of clinical features (symptoms severity, co-morbidities) together with life-style, behavioural, socio-economic and multi-omics parameters. Among the other issues, psycho-cognitive assessment plays a critical role. Coping strategies are used to manage psychological stress. AIM: To evaluate the association between coping strategies and outcome of Pulmonary Rehabilitation (PR). DESIGN: Observational study...
April 14, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28413169/respiratory-effects-of-simultaneous-exposure-to-respirable-crystalline-silica-dust-formaldehyde-and-triethylamine-of-a-group-of-foundry-workers
#10
Fatemeh Zarei, Mansour Rezazadeh Azari, Sousan Salehpour, Soheila Khodakarim, Leila Omidi, Elahe Tavakol
BACKGROUND: Foundry workers are occupationally exposed to hazardous substances such as silica dusts and toxic gases. The aim of this study was to examine the effects of simultaneous exposure to complex mixtures of silica dust, formaldehyde, and triethylamine on lung function parameters. STUDY DESIGN: A cross-sectional study. METHODS: This study was conducted on 55 male workers of core making unit of a foundry plant (the case group) and 55 workers in a food industry were enrolled as a control group in 2015...
March 4, 2017: Journal of Research in Health Sciences
https://www.readbyqxmd.com/read/28400500/differential-hemodynamic-and-respiratory-responses-to-right-and-left-cervical-vagal-nerve-stimulation-in-rats
#11
Harald M Stauss
Neuromodulation through vagal nerve stimulation (VNS) is currently explored for a variety of clinical conditions. However, there are no established VNS parameters for animal models of human diseases, such as hypertension. Therefore, the aim of this study was to assess hemodynamic and respiratory responses to right- or left-sided cervical VNS in a hypertensive rat model. Anesthetized stroke-prone spontaneously hypertensive rats were instrumented for arterial blood pressure and heart rate monitoring and left- or right-sided VNS Cervical VNS was applied through bipolar coil electrodes...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28398925/urgent-chemotherapy-for-life-threatening-complications-related-to-solid-neoplasms
#12
Yoann Zerbib, Antoine Rabbat, Muriel Fartoukh, Naïke Bigé, Claire Andréjak, Julien Mayaux, Nicolas De Prost, Benoît Misset, Virginie Lemiale, Fabrice Bruneel, Julien Maizel, Sylvie Ricome, Frédéric Jacobs, Caroline Bornstain, Hervé Dupont, François Baudin, Elie Azoulay, Frédéric Pène
OBJECTIVES: Solid neoplasms can be directly responsible for organ failures at the time of diagnosis or relapse. The management of such specific complications relies on urgent chemotherapy and eventual instrumental or surgical procedures, combined with advanced life support. We conducted a multicenter study to address the prognosis of this condition. DESIGN: A multicenter retrospective (2001-2015) chart review. SETTING: Medical and respiratory ICUs...
April 10, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28398076/refining-low-physical-activity-measurement-improves-frailty-assessment-in-advanced-lung-disease-and-survivors-of-critical-illness
#13
Matthew R Baldwin, Jonathan P Singer, Debbie Huang, Jessica Sell, Wendy C Gonzalez, Lauren Pollack, Mathew S Maurer, Frank F D'Ovidio, Matthew Bacchetta, Joshua R Sonett, Selim M Arcasoy, Lori Shah, Hilary Robbins, Steven R Hays, Jasleen Kukreja, John R Greenland, Rupal J Shah, Lorriana Leard, Matthew Morrell, Cynthia Gries, Patricia P Katz, Jason D Christie, Joshua M Diamond, David J Lederer
RATIONALE: The frail phenotype has gained popularity as a clinically relevant measure in adults with advanced lung disease and critical illness survivors. Since respiratory disease and chronic illness can greatly limit physical activity, the measurement of participation in traditional leisure-time activities as a frailty component may lead to substantial misclassification of frailty in pulmonary and critical care patients. OBJECTIVES: To test and validate replacing the Duke Activities Scale Index (DASI), a simple 12-item questionnaire, for the Minnesota Leisure Time Activities (MLTA), a detailed questionnaire covering 18 leisure time activities, as the measure of low activity in the Fried frailty phenotype instrument (FFP)...
April 11, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28391305/the-effectiveness-of-singing-or-playing-a-wind-instrument-in-improving-respiratory-function-in-patients-with-long-term-neurological-conditions-a-systematic-review
#14
Kexin Ang, Matthew Maddocks, Huiying Xu, Irene J Higginson
Background: Many long-term neurological conditions adversely affect respiratory function. Singing and playing wind instruments are relatively inexpensive interventions with potential for improving respiratory function; however, synthesis of current evidence is needed to inform research and clinical use of music in respiratory care. Objective: To critically appraise, analyze, and synthesize published evidence on the effectiveness of singing or playing a wind instrument to improve respiratory function in people with long-term neurological conditions...
March 1, 2017: Journal of Music Therapy
https://www.readbyqxmd.com/read/28375853/core-domains-for-clinical-research-in-acute-respiratory-failure-survivors-an-international-modified-delphi-consensus-study
#15
Alison E Turnbull, Kristin A Sepulveda, Victor D Dinglas, Caroline M Chessare, Clifton O Bingham, Dale M Needham
OBJECTIVES: To identify the "core domains" (i.e., patient outcomes, health-related conditions, or aspects of health) that relevant stakeholders agree are essential to assess in all clinical research studies evaluating the outcomes of acute respiratory failure survivors after hospital discharge. DESIGN: A two-round consensus process, using a modified Delphi methodology, with participants from 16 countries, including patient and caregiver representatives. Prior to voting, participants were asked to review 1) results from surveys of clinical researchers, acute respiratory failure survivors, and caregivers that rated the importance of 19 preliminary outcome domains and 2) results from a qualitative study of acute respiratory failure survivors' outcomes after hospital discharge, as related to the 19 preliminary outcome domains...
April 3, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28374410/intrapartum-and-neonatal-outcomes-in-singleton-pregnancies-following-conception-by-assisted-reproduction-techniques
#16
Kellie M Rozdarz, Christopher J Flatley, Sailesh Kumar
BACKGROUND: To characterise maternal demographics and ascertain whether clinically important differences exist in the intrapartum and neonatal outcomes associated with assisted reproductive technology (ART). MATERIALS AND METHODS: A retrospective study was undertaken between January 2007 and December 2013 of all singleton pregnancies conceived via ART at a major tertiary unit in Brisbane, Australia. Intrapartum outcomes were mode of delivery and indication for emergency caesarean...
April 3, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28370685/non-invasive-ethylene-quantification-in-attached-fruit-headspace-at-1-ppb-by-gas-chromatography-mass-spectrometry
#17
Lara Pereira, Marta Pujol, Jordi Garcia-Mas, Michael A Phillips
Ethylene is a gaseous plant hormone involved in defense, adaptations to environmental stress, and fruit ripening. Its relevance to the latter makes its detection highly useful to physiologists interested in ripening onset. Produced as a sharp peak during the respiratory burst, ethylene is biologically active at tens of nL·L(-1) . Reliable quantification at such concentrations generally requires specialized instrumentation. Here we present a rapid, high sensitivity method for detecting ethylene in attached fruit using a conventional gas chromatography - mass spectrometry (GC-MS) system and in situ headspace collection chambers...
March 28, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28355099/validity-of-the-posttraumatic-stress-symptoms-14-instrument-in-acute-respiratory-failure-survivors
#18
Ann M Parker, Sina Nikayin, O Joseph Bienvenu, Dale M Needham
No abstract text is available yet for this article.
March 29, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28355087/reply-validity-of-the-posttraumatic-stress-symptoms-14-instrument-in-acute-respiratory-failure-survivors
#19
Michael W Sjoding, Samuel M Brown, Marc Moss, Derek C Angus, Theodore J Iwashyna
No abstract text is available yet for this article.
March 29, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28344635/the-combination-of-gas-phase-fluorophore-technology-and-automation-to-enable-high-throughput-analysis-of-plant-respiration
#20
Andrew P Scafaro, A Clarissa A Negrini, Brendan O'Leary, F Azzahra Ahmad Rashid, Lucy Hayes, Yuzhen Fan, You Zhang, Vincent Chochois, Murray R Badger, A Harvey Millar, Owen K Atkin
BACKGROUND: Mitochondrial respiration in the dark (Rdark) is a critical plant physiological process, and hence a reliable, efficient and high-throughput method of measuring variation in rates of Rdark is essential for agronomic and ecological studies. However, currently methods used to measure Rdark in plant tissues are typically low throughput. We assessed a high-throughput automated fluorophore system of detecting multiple O2 consumption rates. The fluorophore technique was compared with O2-electrodes, infrared gas analysers (IRGA), and membrane inlet mass spectrometry, to determine accuracy and speed of detecting respiratory fluxes...
2017: Plant Methods
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