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https://www.readbyqxmd.com/read/29417695/visual-perceptual-skills-and-visual-motor-integration-in-children-and-adolescents-after-allogeneic-hematopoietic-stem-cell-transplantation
#1
Kristina Teär Fahnehjelm, Alba Lucia Törnquist, Monica Olsson, Jacek Winiarski, Ulla Ek
The aim of the study was to study visual acuity, visual perceptual, and VMI skills in patients after HSCT in childhood. Tests of visual perceptual skills, VMI, and visual acuity were performed in 102 children/adolescents (age range 4.3-20.9 years). Mean time from HSCT to testing was 6.0 years (0.9-17.5 years). Visual acuity was median 1.0 decimal (range 0.16-1.6). Visual perceptual skills (memory, form constancy, visual sequential memory) and VMI were low compared to age-equivalent normative data with, respectively, 36%, 45%, 60%, and 46% of all patients performing below the 25 percentile...
February 8, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29370963/comparisons-of-visual-attention-in-school-age-children-with-cochlear-implants-versus-hearing-peers-and-normative-data
#2
Michael Hoffman, Elena Tiddens, Alexandra L Quittner
OBJECTIVE: Previous research has found that preschoolers with hearing loss have worse visual attention and elevated rates of behavior problems when compared to typically hearing peers (Barker et al., 2009). However, little is known about these deficits in school-age children with cochlear implants (CIs). We evaluated visual selective attention in school-age children with CIs and hearing peers and examined the link between visual attention and behavior problems. METHOD: Data were drawn from the Childhood Development after Cochlear Implantation (CDaCI) study, the largest longitudinal, multi-site study of children with CIs...
January 9, 2018: Hearing Research
https://www.readbyqxmd.com/read/29327796/speech-characteristics-in-the-congenital-and-childhood-onset-forms-of-myotonic-dystrophy-type-1
#3
Lotta Sjögreen, Åsa Mårtensson, Anne-Berit Ekström
BACKGROUND: Myotonic dystrophy type 1 (DM1) is a slowly progressive multi-systemic disease with an autosomal-dominant inheritance caused by a mutation on chromosome 19 (19q13.3). AIMS: To explore speech characteristics in a group of individuals with the congenital and childhood-onset forms of DM1 in terms of intelligibility, speech-sound production, nasality and compensatory articulation. A further aim was to analyse whether speech characteristics were correlated to subforms of DM1 and if speech outcome could be related to muscle strength...
January 12, 2018: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29297597/validation-of-a-novel-scoring-system-for-changes-in-skeletal-manifestations-of-hypophosphatasia-in-newborns-infants-and-children-the-radiographic-global-impression-of-change-scale
#4
Michael P Whyte, Kenji P Fujita, Scott Moseley, David D Thompson, William H McAlister
Hypophosphatasia (HPP) is the heritable metabolic disease characterized by impaired skeletal mineralization due to low activity of the tissue-nonspecific isoenzyme of alkaline phosphatase. Although HPP during growth often manifests with distinctive radiographic skeletal features, no validated method was available to quantify them, including changes over time. We created the Radiographic Global Impression of Change (RGI-C) scale to assess changes in the skeletal burden of pediatric HPP. Site-specific pairs of radiographs of newborns, infants, and children with HPP from 3 clinical studies of asfotase alfa, an enzyme replacement therapy for HPP, were obtained at Baseline and during treatment...
January 3, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29296871/quality-of-life-of-hurler-syndrome-patients-after-successful-hematopoietic-stem-cell-transplantation
#5
Mieke Aldenhoven, Brigitte T A van den Broek, Robert F Wynn, Anne O'Meara, Paul Veys, Attilio Rovelli, Simon A Jones, Rossella Parini, Peter M van Hasselt, Marleen Renard, Victoria Bordon, Tom J de Koning, Jaap Jan Boelens
Hurler syndrome (HS) is a lysosomal storage disease characterized by multisystem morbidity and death in early childhood. Hematopoietic stem cell transplantation (HSCT) results in long-term survival, although with significant residual disease burden. How this residual disease affects the health-related quality of life is unknown. Therefore, we conducted a multicenter cohort study on functional and psychosocial health and compared the outcomes to normative data using the Child Health Questionnaire and Pediatric Outcomes Data Collection Instrument...
November 14, 2017: Blood Advances
https://www.readbyqxmd.com/read/29280917/long-term-variability-of-distortion-product-otoacoustic-emissions-in-infants-and-children-and-its-relation-to-pediatric-ototoxicity-monitoring
#6
Dawn Konrad-Martin, Kristin Knight, Garnett P McMillan, Laura E Dreisbach, Elsa Nelson, Marilyn Dille
OBJECTIVE: Distortion-product otoacoustic emissions (DPOAEs) provide a rapid, noninvasive measure of outer hair cell damage associated with chemotherapy and are a key component of pediatric ototoxicity monitoring. Serial monitoring of DPOAE levels in reference to baseline measures is one method for detecting ototoxic damage. Interpreting DPOAE findings in this context requires that test-retest differences be considered in relation to normal variability, data which are lacking in children...
December 26, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/29105091/links-between-contexts-and-middle-to-late-childhood-social-emotional-development
#7
Jeffrey Duong, Catherine P Bradshaw
Guided by the social-emotional learning (SEL) framework, we studied developmental trajectory patterns of five key competency outcomes spanning middle through late childhood: altruism, empathy, self-efficacy, aggression, and hyperactivity. We then assessed their links to middle childhood home, parental, and community contexts. Data from the Institute of Education Sciences' Social and Character Development Program, which comprised nearly 2,400 elementary school students who were followed from Grades 3 through 5, were analyzed using growth mixture modeling...
November 3, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/29105061/annual-research-review-not-just-a-small-adult-brain-understanding-later-neurodevelopment-through-imaging-the-neonatal-brain
#8
REVIEW
Dafnis Batalle, A David Edwards, Jonathan O'Muircheartaigh
BACKGROUND: There has been a recent proliferation in neuroimaging research focusing on brain development in the prenatal, neonatal and very early childhood brain. Early brain injury and preterm birth are associated with increased risk of neurodevelopmental disorders, indicating the importance of this early period for later outcome. SCOPE AND METHODOLOGY: Although using a wide range of different methodologies and investigating diverse samples, the common aim of many of these studies has been to both track normative development and investigate deviations in this development to predict behavioural, cognitive and neurological function in childhood...
November 3, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29071103/definition-of-new-cut-offs-of-bmi-and-waist-circumference-based-on-body-composition-and-insulin-resistance-differences-between-children-adolescents-and-adults
#9
M Hübers, M Pourhassan, W Braun, C Geisler, M J Müller
OBJECTIVE: This study aims to determine associations between anthropometric traits, regional fat depots and insulin resistance in children, adolescents and adults to define new cut-offs of body mass index (BMI) or waist circumference (WC). DESIGN: Cross-sectional data were assessed in 433 children, adolescents and adults (aged: 6-60 years, BMI: 23.6 [21.0-27.7] kg m-2). Total adipose tissue (TAT), regional subcutaneous adipose tissue (SATtotal, SATtrunk) and visceral adipose tissue (VAT) were determined by whole-body magnetic resonance imaging, fat mass by air-displacement plethysmography...
September 2017: Obesity Science & Practice
https://www.readbyqxmd.com/read/29057169/the-co-development-of-relational-aggression-and-disruptive-behavior-symptoms-from-late-childhood-through-adolescence
#10
Alazne Aizpitarte, Olivia E Atherton, Richard W Robins
Researchers have debated whether relational aggression is a developmentally-normative behavior or a sign of some underlying psychopathology. However, due to the dearth of longitudinal studies, we know little about how relational aggression and more severe forms of disruptive behavior co-develop. The present study examined bidirectional associations between relational aggression and two psychiatric disorders, Oppositional Defiant Disorder (ODD) and Conduct Disorder (CD), using data from a longitudinal study of 674 Mexican-origin youth followed from age 10 to 16...
September 2017: Clinical Psychological Science
https://www.readbyqxmd.com/read/29021237/recommendations-for-collaborative-paediatric-research-including-biobanking-in-europe-a-single-hub-and-access-point-for-paediatric-rheumatology-in-europe-share-initiative
#11
Jasmin B Kuemmerle-Deschner, Sandra Hansmann, Nico M Wulffraat, Sebastiaan J Vastert, Kristien Hens, Jordi Anton, Tadej Avcin, Alberto Martini, Isabelle Koné-Paut, Yosef Uziel, Angelo Ravelli, Carine Wouters, David Shaw, Seza Özen, Andreas Eikelberg, Berent J Prakken, Nicolino Ruperto, Gerd Horneff, Tamas Constantin, Michael W Beresford, Marijn Sikken, Helen E Foster, Iris Haug, Sabrina Schuller, Christine Jägle, Susanne M Benseler
Innovative research in childhood rheumatic diseases mandates international collaborations. However, researchers struggle with significant regulatory heterogeneity; an enabling European Union (EU)-wide framework is missing. The aims of the study were to systematically review the evidence for best practice and to establish recommendations for collaborative research. The Paediatric Rheumatology European Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) project enabled a scoping review and expert discussion, which then informed the systematic literature review...
October 11, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28981187/defining-healthy-in-preschool-aged-children-for-forced-oscillation-technique-reference-equations
#12
Claire Shackleton, Dorottya Czovek, Keith Grimwood, Robert S Ware, Bence Radics, Zoltan Hantos, Peter D Sly
BACKGROUND AND OBJECTIVE: Selecting 'healthy' preschool-aged children for reference ranges may not be straightforward. Relaxing inclusion criteria for normative data does not affect spirometry z-scores. We therefore investigated the effect of similarly relaxing inclusion criteria in preschoolers on reference ranges for respiratory impedance (Zrs) using a modified forced oscillation technique (FOT). METHODS: The International Study of Asthma and Allergies in Childhood questionnaire classified 585 children into a healthy and five mutually exclusive groups...
October 5, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28915338/neurocognitive-psychosocial-and-quality-of-life-outcomes-in-adult-survivors-of-childhood-non-hodgkin-lymphoma
#13
Matthew J Ehrhardt, Daniel A Mulrooney, Chenghong Li, Malek J Baassiri, Kari Bjornard, John T Sandlund, Tara M Brinkman, I-Chan Huang, Deo Kumar Srivastava, Kirsten K Ness, Leslie L Robison, Melissa M Hudson, Kevin R Krull
BACKGROUND: Children with non-Hodgkin lymphoma (NHL) undergo treatment with central nervous system-directed therapy, the potentially neurotoxic effects of which have not been reported in NHL survivors. METHODS: NHL survivors (n = 187) participating in the St. Jude Lifetime Cohort who were 10 or more years from their diagnosis and were 18 years old or older underwent neurocognitive, emotional distress (Brief Symptom Inventory 18), and health-related quality of life (HRQOL) assessments (36-Item Short Form Health Survey)...
September 15, 2017: Cancer
https://www.readbyqxmd.com/read/28875228/myocardial-deformation-assessed-by-longitudinal-strain-chamber-specific-normative-data-for-cmr-feature-tracking-from-the-german-competence-network-for-congenital-heart-defects
#14
Quanliang Shang, Shivani Patel, Michael Steinmetz, Andreas Schuster, David A Danford, Philipp Beerbaum, Samir Sarikouch, Shelby Kutty
PURPOSE: Left ventricular two-dimensional global longitudinal strain (LS) is superior to ejection fraction (EF) as predictor of outcome. We provide reference data for atrial and ventricular global LS during childhood and adolescence by CMR feature tracking (FT). METHODS: We prospectively enrolled 115 healthy subjects (56 male, mean age 12.4 ± 4.1 years) at a single institution. CMR consisted of standard two-dimensional steady-state free-precession acquisitions...
September 5, 2017: European Radiology
https://www.readbyqxmd.com/read/28858189/sex-related-differences-in-the-developmental-morphology-of-the-atlas-a-computed-tomography-study
#15
Mitsuru Asukai, Tomotada Fujita, Daisuke Suzuki, Tatsuya Nishida, Tsuyoshi Ohishi, Yukihiro Matsuyama
STUDY DESIGN: A retrospective study. OBJECTIVE: To elucidate sex-related differences in the age at synchondroses closure, the normative size of the atlas, and the ossification patterns of the atlas in Japanese children. SUMMARY OF BACKGROUND DATA: The atlas develops from three ossification centers during childhood. The anterior and posterior synchondroses, which are separate ossification centers, mimic fracture lines on computed tomography (CT)...
August 23, 2017: Spine
https://www.readbyqxmd.com/read/28763713/spatiotemporal-and-plantar-pressure-patterns-of-1000-healthy-individuals-aged-3-101-years
#16
Marnee J McKay, Jennifer N Baldwin, Paulo Ferreira, Milena Simic, Natalie Vanicek, Elizabeth Wojciechowski, Anita Mudge, Joshua Burns
OBJECTIVE: The purpose of this study was to establish normative reference values for spatiotemporal and plantar pressure parameters, and to investigate the influence of demographic, anthropometric and physical characteristics. METHODS: In 1000 healthy males and females aged 3-101 years, spatiotemporal and plantar pressure data were collected barefoot with the Zeno™ walkway and Emed(®) platform. Correlograms were developed to visualise the relationships between widely reported spatiotemporal and pressure variables with demographic (age, gender), anthropometric (height, mass, waist circumference) and physical characteristics (ankle strength, ankle range of motion, vibration perception) in children aged 3-9 years, adolescents aged 10-19 years, adults aged 20-59 years and older adults aged over 60 years...
October 2017: Gait & Posture
https://www.readbyqxmd.com/read/28760908/impact-of-the-underlying-etiology-of-growth-hormone-deficiency-on-serum-igf-i-sds-levels-during-gh-treatment-in-children
#17
Juliane Léger, Damir Mohamed, Sophie Dos Santos, Myriam Ben Azoun, Delphine Zénaty, Dominique Simon, Anne Paulsen, Laetitia Martinerie, Didier Chevenne, Corinne Alberti, Jean-Claude Carel, Sophie Guilmin-Crepon
CONTEXT: Regular monitoring of serum IGF-I levels during growth hormone (GH) therapy has been recommended, for assessing treatment compliance and safety. OBJECTIVE: To investigate serum IGF-I SDS levels during GH treatment in children with GH deficiency, and to identify potential determinants of these levels. DESIGN, PATIENTS AND METHODS: This observational cohort study included all patients (n = 308) with childhood-onset non-acquired or acquired GH deficiency (GHD) included in the database of a single academic pediatric care center over a period of 10 years for whom at least one serum IGF-I SDS determination during GH treatment was available...
September 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28757148/transdiagnostic-psychiatric-disorder-risk-associated-with-early-age-of-menarche-a-latent-modeling-approach
#18
Jonathan M Platt, Natalie L Colich, Katie A McLaughlin, Dahsan Gary, Katherine M Keyes
BACKGROUND: Earlier age of pubertal maturation in females is associated with increased risk for mental health problems in adolescence, compared with on-time or later maturation. However, most investigations of pubertal timing and mental health consider risk for individual disorders and fail to account for comorbidity. A latent-modeling approach using a large, nationally representative sample could better explain the transdiagnostic nature of the consequences of early-onset puberty. METHODS: Data on age of menarche and mental disorders were drawn from a population-representative sample of adolescents (n=4925), ages 13-17...
November 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28662138/longitudinal-changes-in-macular-retinal-layer-thickness-in-pediatric-populations-myopic-vs-non-myopic-eyes
#19
Scott A Read, David Alonso-Caneiro, Stephen J Vincent
Knowledge of the normal in vivo thickness of the retina, and its individual layers in pediatric populations is important for diagnosing and monitoring retinal disorders, and for understanding the eye's normal development and the impact of eye growth and refractive error such as myopia (short-sightedness) upon retinal morphology. In this prospective, observational longitudinal study, total retinal thickness (and individual retinal layer thickness) and the changes in retinal morphology occurring over an 18-month period were examined in 101 children with a range of refractive errors...
2017: PloS One
https://www.readbyqxmd.com/read/28659295/infant-feeding-and-growth-trajectory-patterns-in-childhood-and-body-composition-in-young-adulthood
#20
Peter Rzehak, Wendy H Oddy, M Luisa Mearin, Veit Grote, Trevor A Mori, Hania Szajewska, Raanan Shamir, Sibylle Koletzko, Martina Weber, Lawrence J Beilin, Rae-Chi Huang, Berthold Koletzko
Background: Growth patterns of breastfed and formula-fed infants may differ, with formula-fed infants growing more rapidly than breastfed infants into childhood and adulthood.Objective: Our objectives were to identify growth patterns and investigate early nutritional programming potential on growth patterns at 6 y and on body composition at 20 y.Design: The West Australian Pregnancy Cohort (Raine) Study and 3 European cohort studies (European Childhood Obesity Trial, Norwegian Human Milk Study, and Prevention of Coeliac Disease) that collaborate in the European Union-funded Early Nutrition project combined, harmonized, and pooled data on full breastfeeding, anthropometry, and body composition...
August 2017: American Journal of Clinical Nutrition
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