keyword
MENU ▼
Read by QxMD icon Read
search

rtpa

keyword
https://www.readbyqxmd.com/read/29769590/low-factor-xiii-levels-after-intravenous-thrombolysis-predict-short-term-mortality-in-ischemic-stroke-patients
#1
Edina Gabriella Székely, Katalin Réka Czuriga-Kovács, Zsuzsanna Bereczky, Éva Katona, Zoltán András Mezei, Attila Nagy, Noémi Klára Tóth, Ervin Berényi, László Muszbek, László Csiba, Zsuzsa Bagoly
In this observational study we investigated whether levels of factor XIII (FXIII) and its major polymorphisms affect the outcome of thrombolysis by recombinant tissue plasminogen activator (rtPA) in acute ischemic stroke (AIS) patients. Study cohort included 132 consecutive AIS patients undergoing i.v. thrombolysis within 4.5 h of symptom onset. Blood samples taken on admission, immediately after and 24 h after therapy were analyzed for FXIII activity and antigen levels. FXIII-A p.Val34Leu, p.Tyr204Phe, FXIII-B p...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29720437/prediction-of-tissue-outcome-and-assessment-of-treatment-effect-in-acute-ischemic-stroke-using-deep-learning
#2
Anne Nielsen, Mikkel Bo Hansen, Anna Tietze, Kim Mouridsen
BACKGROUND AND PURPOSE: Treatment options for patients with acute ischemic stroke depend on the volume of salvageable tissue. This volume assessment is currently based on fixed thresholds and single imagine modalities, limiting accuracy. We wish to develop and validate a predictive model capable of automatically identifying and combining acute imaging features to accurately predict final lesion volume. METHODS: Using acute magnetic resonance imaging, we developed and trained a deep convolutional neural network (CNNdeep ) to predict final imaging outcome...
May 2, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29624859/comparison-between-open-and-pharmacomechanical-repair-of-acutely-thrombosed-arteriovenous-hemodialysis-fistulae-within-a-decade
#3
Susanne Regus, Veronika Almási-Sperling, Ulrich Rother, Alexander Meyer, Axel Schmid, Michael Uder, Werner Lang
INTRODUCTION: Different declotting techniques are available for acutely thrombosed arteriovenous hemodialysis fistulae (AVF). The aim of this single-center study was to compare immediate and follow-up results between surgical repair and a modified interventional lyse-and-wait technique characterized by prolonged local reaction times of recombinant tissue-plasminogen activator (rtPA). MATERIALS AND METHODS: We retrospectively analyzed medical records of 110 consecutively treated patients between the years 2003 and 2013...
April 6, 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29602953/indole-3-carbinol-improves-neurobehavioral-symptoms-in-a-cerebral-ischemic-stroke-model
#4
Pankaj Paliwal, Gaurav Chauhan, Deepa Gautam, Debabrata Dash, Shashikant C U Patne, Sairam Krishnamurthy
Stroke is one of the most common causes of death worldwide and also responsible for permanent disability. Ischemic stroke has been found to affect 80% of stroke patients. Recombinant tissue plasminogen activator (rtPA) is the widely used drug for the ischemic stroke with narrow therapeutic window. Indole-3-carbinol (I3C) is a natural compound obtained from brassica species having antithrombotic activity. Middle cerebral artery occlusion (MCAO) model was used followed by reperfusion after 2 h of ischemia for the evaluation of the I3C against ischemic stroke...
March 30, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29602862/safety-and-efficacy-of-mechanical-thrombectomy-in-acute-ischemic-stroke-of-anticoagulated-patients
#5
Vincent L'Allinec, Marielle Ernst, Mathieu Sevin-Allouet, Nathalie Testard, Béatrice Delasalle-Guyomarch, Benoit Guillon, Mikael Mazighi, Hubert Desal, Romain Bourcier
BACKGROUND: Anticoagulated patients (APs) are currently excluded from acute ischemic stroke reperfusion therapy with intravenous recombinant tissue plasminogen activator (IV-rtPA); however, these patients could benefit from mechanical thrombectomy (MT). Evidence for MT in this condition remains scarce. The aim of this study was to analyze the safety and efficacy of MT in APs. METHODS: We analyzed three patient groups from two prospective registries: APs with MT (AP-MT group), non-anticoagulated patients treated with MT (NAP-MT group), and non-anticoagulated patients treated with IV-rtPA and MT (NAP-IVTMT group)...
March 30, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29600005/current-status-of-intravenous-tissue-plasminogen-activator-dosage-for-acute-ischaemic-stroke-an-updated-systematic-review
#6
Xia Wang, Shoujiang You, Shoichiro Sato, Jie Yang, Cheryl Carcel, Danni Zheng, Sohei Yoshimura, Craig S Anderson, Else Charlotte Sandset, Thompson Robinson, John Chalmers, Vijay K Sharma
The optimal dose of recombinant tissue plasminogen activator (rtPA) for acute ischaemic stroke (AIS) remains controversial, especially in Asian countries. We aimed to update the evidence regarding the use of low-dose versus standard-dose rtPA. We performed a systematic literature search across MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), PsycINFO and Cumulative Index to Nursing and Allied Health Literature (CINAHL) from inception to 22 August 2016 to identify all related studies...
March 2018: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/29571851/in-a-stroke-cohort-with-incident-hypertension-are-more-women-than-men-likely-to-be-excluded-from-recombinant-tissue-type-plasminogen-activator-rtpa
#7
Jordan Gainey, Leanne Brechtel, Sarah Konklin, Lee Madeline, Ervin Lowther, Brice Blum, Thomas I Nathaniel
BACKGROUND: The treatment outcomes in the use of rt-PA have been reported. Some studies reported worse outcome in women than men, while others presented opposing data. Using data from a hospital-based stroke registry, we investigated evidence of gender difference and determined exclusion criteria in a stroke population with incidence of hypertension. METHOD: In a stroke population of women and men with incident of hypertension from a stroke registry, demographics and clinical factors were compared...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29570044/alteplase-for-the-treatment-of-acute-ischemic-stroke-in-patients-with-low-national-institutes-of-health-stroke-scale-and-not-clearly-disabling-deficits-potential-of-rtpa-for-ischemic-strokes-with-mild-symptoms-prisms-rationale-and-design
#8
Sharon D Yeatts, Joseph P Broderick, Anjan Chatterjee, Edward C Jauch, Steven R Levine, Jose G Romano, Jeffrey L Saver, Achala Vagal, Barbara Purdon, Jenny Devenport, Pooja Khatri
Rationale Over half of acute ischemic stroke patients have a low National Institutes of Health Stroke Scale of 0-5 and up to two-thirds may not appear clearly disabled at presentation. The efficacy of intravenous alteplase for the latter group is not known. Aim Potential of rtPA for Ischemic Strokes with Mild Symptoms (PRISMS) was designed to evaluate the safety and efficacy of intravenous alteplase for the treatment of acute ischemic stroke with National Institutes of Health Stroke Scale 0-5 and without clearly disabling deficits...
January 1, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29564653/effect-of-irrigation-on-fibrinolytic-rtpa-therapy-in-a-clot-model-of-intracerebral-haemorrhage-a-systematic-in-vitro-study
#9
Julia Masomi-Bornwassser, Fabio Freguia, Hendrik Müller-Werkmeister, Oliver Kempski, Alf Giese, Naureen Keric
OBJECTIVE: Although fibrinolytic therapy is an upcoming treatment for intracerebral haemorrhage (ICH), standard guidelines are lacking, and some clinical issues persist. Here, we used our recently devised clot model of ICH to systematically analyse effects of irrigation and cerebrospinal fluid (CSF) on fibrinolysis. METHODS: In vitro clots of human blood (25 ml) were generated and a catheter irrigation system was applied to deliver fluid/treatment. Clots were weighed before and after treatment and compared to rtPA treatment alone...
March 21, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29547062/tissue-type-plasminogen-activator-protects-the-postsynaptic-density-in-the-ischemic-brain
#10
Valerie Jeanneret, Juan P Ospina, Ariel Diaz, Luis G Manrique, Paola Merino, Laura Gutierrez, Enrique Torre, Fang Wu, Lihong Cheng, Manuel Yepes
Cerebral ischemia causes the presynaptic release of tissue-type plasminogen activator (tPA). The postsynaptic density (PSD) is a postsynaptic structure that provides a matrix where signaling transduction of excitatory synapses takes place. The postsynaptic density protein-95 (PSD-95) is the most abundant scaffolding protein in the postsynaptic density (PSD), where it modulates the postsynaptic response to the presynaptic release of glutamate by regulating the anchoring of glutamate receptors to the PSD. We found that tPA induces the local translation of PSD-95 mRNA and the subsequent recruitment of PSD-95 protein to the PSD, via plasminogen-independent activation of TrkB receptors...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29545057/intravenous-recombinant-tissue-plasminogen-activator-and-ischemic-stroke-focused-update-of-2010-clinical-practice-advisory-from-the-american-academy-of-emergency-medicine
#11
William J Meurer, Bradley Barth, Michael Abraham, Jerome Hoffman, Gary M Vilke, Gerard DeMers
BACKGROUND: Stroke treatment is a continuum that begins with the rapid identification of symptoms and treatment with transition to successful rehabilitation. Therapies for acute ischemic stroke (AIS) may vary based on anatomic location, interval from symptom onset, and coexisting health conditions. Successful therapy requires a seamless systematic approach with coordination from prehospital environment through acute management at medical facilities to disposition and long-term care of the patient...
March 12, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29541519/transcranial-diffuse-optical-assessment-of-the-microvascular-reperfusion-after-thrombolysis-for-acute-ischemic-stroke
#12
Raquel Delgado-Mederos, Clara Gregori-Pla, Peyman Zirak, Igor Blanco, Lavinia Dinia, Rebeca Marín, Turgut Durduran, Joan Martí-Fàbregas
In this pilot study, we have evaluated bedside diffuse optical monitoring combining diffuse correlation spectroscopy and near-infrared diffuse optical spectroscopy to assess the effect of thrombolysis with an intravenous recombinant tissue plasminogen activator (rtPA) on cerebral hemodynamics in an acute ischemic stroke. Frontal lobes of five patients with an acute middle cerebral artery occlusion were measured bilaterally during rtPA treatment. Both ipsilesional and contralesional hemispheres showed significant increases in cerebral blood flow, total hemoglobin concentration and oxy-hemoglobin concentration during the first 2...
March 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29525730/a-comparison-of-two-stroke-cohorts-cared-for-by-two-different-specialties-in-a-practice-based-tele-stroke-population
#13
Elias Atallah, Kimon Bekelis, Hassan Saad, Nohra Chalouhi, Sophia Dang, Jonathan Li, Ayan Kumar, Justin Turpin, Randa Barsoom, Stavropoula Tjoumakaris, David Hasan, Maureen Deprince, Giuliana Labella, Robert H Rosenwasser, Pascal Jabbour
OBJECTIVES: Neurologists have continually led the assessment and management of Acute Ischemic Stroke(AIS) by use of IV-rtPA, anti-platelet therapy, antihypertensives, and other pharmacologic agents. Since the advent of mechanical thrombectomy(MT) and its proven efficacy, neurovascular surgeons(NS) are playing an increasingly important role in the management and overall care of AIS. We assessed outcomes of AIS patients managed by NS, who have been traditionally managed by neurologists...
May 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29507028/stroke-thrombolysis-complicated-by-st-elevation-myocardial-infarction-stemi
#14
Mark Flower, James Harvey, Jonathan Hunter
An 84-year-old male Jehovah's Witness presented to the emergency department 1 hour after onset of left facial droop and left upper limb weakness. Thrombolytic stroke treatment was commenced as per local thrombolytic protocol with intravenous recombinant tissue plasminogen activator (rtPA) at 2 hours and 25 min following onset of symptoms. Almost immediately after rtPA infusion the patient reported chest pain and had ECG changes consistent with a diagnosis of anterior ST elevation myocardial infarction...
March 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29505787/thrombolytic-therapies-for-ischemic-stroke-triumphs-and-future-challenges
#15
REVIEW
Aimen Moussaddy, Andrew M Demchuk, Michael D Hill
Acute stroke therapy has significantly evolved over the last two decades. The two main advances have been the approval of intravenous chemical thrombolysis in 1995, and the approval of intra-arterial mechanical thrombectomy in 2015. This has led to significant improvement of functional outcomes in a disease known to be the first cause of disability worldwide. Subsequent studies have focused on identifying pre-treatment predictors of good treatment candidates, by developing biochemical and imaging biomarkers...
March 3, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29501045/effects-of-edaravone-the-free-radical-scavenger-on-outcomes-in-acute-cerebral-infarction-patients-treated-with-ultra-early-thrombolysis-of-recombinant-tissue-plasminogen-activator
#16
Xian-Ru Lee, Gui-Ling Xiang
OBJECTIVES: Edaravone, a free radical scavenger, alleviates blood-brain barrier disruption in conjunction with suppression of the inflammatory reaction in acute cerebral infarction. Thrombolysis with recombinant tissue plasminogen activator (rtPA) is an established therapy for acute cerebral infarction patients. The purpose of this study was to assess the effects of edaravone on outcomes in acute cerebral infarction patients treated with ultra-early thrombolysis of iv-rt-PA. PATIENTS AND METHODS: We conducted a retrospective cohort study using the database of Ningbo First Hospital...
April 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29445435/investigation-of-gender-differences-and-exclusive-criteria-in-a-diabetic-acute-ischemic-stroke-population-treated-with-recombinant-tissue-type-plasminogen-activator-rtpa
#17
Taylor Wapshott, Brice Blum, Williams Kelsey, Thomas I Nathaniel
Background: Many studies have reported that women who survive stroke have less favorable outcomes than men in the use of rtPA, while others reported worse outcomes in men than women. The gender difference in the exclusion criteria in a diabetic stroke population is not fully understood. This issue was investigated in this study. Method: In a diabetic stroke population from a stroke registry of data collected between January 2010 to June 30, 2016, the gender difference was determined using demographics and clinical factors...
December 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29431157/thrombolysis-of-a-stroke-patient-with-history-of-rtpa-associated-angioedema
#18
Felipe De Los Rios La Rosa, Amy K Starosciak, Brian Wolf
No abstract text is available yet for this article.
December 2017: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29313057/regional-differences-in-thrombectomy-rates-secondary-use-of-billing-codes-in-the-miracum-medical-informatics-for-research-and-care-in-university-medicine-consortium
#19
Christian Haverkamp, Thomas Ganslandt, Petar Horki, Martin Boeker, Arnd Dörfler, Stefan Schwab, Joachim Berkefeld, Waltraud Pfeilschifter, Wolf-Dirk Niesen, Karl Egger, Manfred Kaps, Marc A Brockmann, Eva Neumaier-Probst, Kristina Szabo, Martin Skalej, Siegfried Bien, Christoph Best, Hans-Ulrich Prokosch, Horst Urbach
BACKGROUND AND PURPOSE: Mechanical thrombectomy, in addition to intravenous (i.v.) thrombolysis is recommended for treatment of acute stroke in patients with large vessel occlusions (LVO) in the anterior circulation up to 6 h after symptom onset. We compared thrombectomy rates of eight university hospitals of the MIRACUM consortium to analyze the implementation of this guideline in clinical routine. METHODS: Anonymized billing data in a standardized format were loaded into a local i2b2 data warehouse by applying already existing extract, transform and load (ETL) routines...
January 8, 2018: Clinical Neuroradiology
https://www.readbyqxmd.com/read/29304529/passivating-injured-endothelium-with-kinexins-in-thrombolytic-therapy
#20
Yunn-Hwa Ma, Chao-Wei Huang, Chih-Jen Wen, Yi-Ching Lu, Shiaw-Pyng Wey, Tze-Chein Wun
Without conjunctive administration of an anticoagulant, endothelial injury-induced thrombosis is resistant to thrombolysis and prone to re-thrombosis. We hypothesized that co-delivery of recombinant tissue plasminogen activator (rtPA) with annexin V-containing anticoagulants that specifically target the injured endothelium may passivate the thrombogenic elements of the vascular injury site and enhance rtPA-induced thrombolysis. In this study, the effects of conjunctive administration of Kinexins (Kunitz inhibitor-annexin V fusion proteins) with rtPA on thrombolysis were determined in vitro and in vivo ...
January 2018: Thrombosis and Haemostasis
keyword
keyword
65230
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"