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psoralea corylifolia

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https://www.readbyqxmd.com/read/29187671/bavachin-induces-apoptosis-through-mitochondrial-regulated-er-stress-pathway-in-hepg2-cells
#1
Ying Yang, Xianglin Tang, Feiran Hao, Zengchun Ma, Yuguang Wang, Lili Wang, Yue Gao
As a traditional herbal medicine, the fruits of Psoralea corylifolia L. (FP) have been widely used for the treatment of various skin diseases for hundred years. Recently, the emerging FP-induced toxic effects, especially hepatotoxicity, in clinic are getting the public's attention. However, its exact toxic components and mechanisms underlying remain unclear. Bavachin, one of flavonoids in FP, has been documented as a hepatotoxic substance, and the present study aimed to determine the toxicity caused by bavachin and the possible toxic mechanisms involved using HepG2 cells...
November 29, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29180062/metabolic-detoxification-of-bakuchiol-is-mediated-by-oxidation-of-cyp-450s-in-liver-microsomes
#2
Xiao-Jing Hu, You-Bo Zhang, Zi-Jing Zhao, Lei Zhang, Qi Wang, Xiu-Wei Yang
Bakuchiol, one of bioactive compounds isolated from the dried ripe fruits of Psoralea corylifolia L., possesses a variety of pharmacological activities. In this study, the metabolites of bakuchiol in rat liver microsomes as well as their cytotoxicities were studied. A total of eight metabolites were isolated and identified as 14-carboxylbakuchiol (M1), 14,15-dihydroxybakuchiol (M2), 12,13-dihydroxybakuchiol (M3), 15-hydroxybakuchiol (M4), 14-hydroxybakuchiol (M5), bakuchiol hydrate (M6), 15-hydroxybakuchiol acetate (M7), and 14-hydroxybakuchiol acetate (M8)...
November 24, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29156966/chemical-constituents-from-the-fruits-of-psoralea-corylifolia-and-their-protective-effects-on-ionising-radiation-injury
#3
Jie Du, Chun-Hua Wang, Jing Yang, Xin He, Xiao-Liang Han, Cong-Cong Li, Xin Chai, Yue-Fei Wang, Yan Zhu, Zheng Li
Two new flavonoids, corylifol F (1) and corylifol G (2), together with 19 known compounds, were isolated from the fruits of Psoralea corylifolia L.. The structures of these compounds were determined by interpretation of spectroscopic data and comparison with literature properties. The radioprotective effects of the isolated compounds against ionising radiation damage were also evaluated in vitro. The results showed that corylifol A exhibited radioprotective effects in both HBL-100 and MCF-7 cells, while psoralen, isopsoralen, corylifol C and bakuchiol showed obvious selective action to protect HBL-100 cells against damage caused by ionising radiation...
November 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29082707/-determination-and-pharmacokinetics-of-main-components-for-psoralea-corylifolia-myristica-fragrants-drug-pair-by-using-uplc-ms-ms
#4
Jia-Rong Gao, Shuang-Zhi Xu, Yan-Quan Han, Liang-Bing Wei, Hui Jiang, Jun-Mei Song, Xue Xue
To conduct multiple-reaction monitoring(MRM) quantitative analysis with ultra-high performance liquid chromatography coupled with mass spectrometry method(UPLC-MS/MS), determine the concentrations of psoralen, isopsoralen, bakuchiol and dehydrodiisoeugenol in plasma under positive iron mode with chloramghenicol as internal standard, and investigate the pharmacokinetics process of the main components before and after oral administration of drug pair Psoralea corylifolia -Myristica fragrants. Thirty-six SD rats were randomly divided into three group(A, B, C) and received P...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29044596/angelicin-potentiates-trail-induced-apoptosis-in-renal-carcinoma-caki-cells-through-activation-of-caspase-3-and-down-regulation-of-c-flip-expression
#5
Kyoung-Jin Min, Hee Jung Um, Seung Un Seo, Seon Min Woo, Shin Kim, Jong-Wook Park, Hyun-Shik Lee, Sang Hyun Kim, Yung Hyun Choi, Tae-Jin Lee, Taeg Kyu Kwon
Preclinical Research & Development Angelicin is a furocoumarin derived from Psoralea corylifolia L. fruit that has anti-inflammatory and anti-tumor activity. In the present study, the effect of angelicin in enhancing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptotic cell death was studied in Caki (renal carcinoma) cells. Angelicin alone and TRAIL alone had no effect on apoptosis, but in combination these compounds markedly induced apoptosis in the cancer cell lines while not inducing apoptosis in normal cells...
October 16, 2017: Drug Development Research
https://www.readbyqxmd.com/read/28990045/anti%C3%A2-tumor-effects-of-bakuchiol-on-human-gastric-carcinoma-cell-lines-are-mediated-through-pi3k-akt-and-mapk-signaling-pathways
#6
Long Lv, Bo Liu
Bakuchiol is extracted from Psoralea corylifolia, a member of the Leguminosae family, has been used in Indian Ayurvedic and Chinese traditional medicine, and it possesses an anticancer effect. The primary aim of the present study was to identify the molecular mechanisms underlying the anticancer effect of bakuchiol monoterpenes. Bakuchiol treatment significantly inhibited NUGC3 human gastric cancer cell viability in a concentration dependent manner. In addition, bakuchiol significantly increased the apoptotic cell population in the sub‑G1 phase, and Annexin‑V‑fluorescein isothiocyanate/propidium iodide double staining confirmed the increase in apoptosis...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28982307/psoralea-corylifolia-extract-induces-vasodilation-in-rat-arteries-through-both-endothelium-dependent-and-independent-mechanisms-involving-inhibition-of-trpc3-channel-activity-and-elaboration-of-prostaglandin
#7
Addis Kassahun Gebremeskel, Tharaka Darshana Wijerathne, Ji Hyun Kim, Min Ji Kim, Chang-Seob Seo, Hyeun-Kyoo Shin, Kyu Pil Lee
CONTEXT: Fructus Psoralea, Psoralea corylifolia L. (Leguminosae), has been widely used in traditional medicines for the treatment of dermatitis, leukoderma, asthma and osteoporosis. OBJECTIVES: In this study, we sought to study mechanisms underlying the vasoactive properties of Psoralea corylifolia extract (PCE) and its active ingredients. MATERIALS AND METHODS: To study mechanisms underlying the vasoactive properties of PCE prepared by extracting dried seeds of Psoralea corylifolia with 70% ethanol, isometric tension recordings of rat aortic rings and the ionic currents through TRPC3 (transient receptor potential canonical 3) channels were measured with the cumulative concentration (10-600 μg/mL) of PCE or its constituents...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28962172/psoralen-stimulates-osteoblast-proliferation-through-the-activation-of-nuclear-factor-%C3%AE%C2%BAb-mitogen-activated-protein-kinase-signaling
#8
Feimeng Li, Qihuo Li, Xiaoqing Huang, Yunting Wang, Chana Ge, Yong Qi, Wei Guo, Hongtao Sun
Osteoporosis is a systemic skeletal disease that leads to increased bone fragility and susceptibility to fracture. Approximately 50% of postmenopausal women develop osteoporosis as a result of postmenopausal estrogen deficiency. To reduce fractures related to osteoporosis in women, previous studies have focused on therapeutic strategies that aim to increase bone formation or decrease bone resorption. However, pharmacological agents that aim to improve bone fracture susceptibility exhibit side effects. Current studies are investigating natural alternatives that possess the benefits of selective estrogen receptor modulators (SERMs) without the adverse effects...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28949389/psoralen-promotes-the-expression-of-cyclin-d1-in-chondrocytes-via-the-wnt-%C3%AE-catenin-signaling-pathway
#9
Wenwei Zheng, Pingdong Lin, Yuhuan Ma, Xiang Shao, Houhuang Chen, Da Chen, Xianxiang Liu, Xihai Li, Hongzhi Ye
Psoralen (PSO), the active ingredient of Fructus Psoraleae (FP) the dried ripe fruit of Psoralea corylifolia L., has been commonly used in traditional Chinese medicine (TCM) for the treatment of osteoarthritis (OA). We found that PSO activates cartilaginous cellular functions of rat chondrocytes in vitro. However, the effect of PSO on chondrocyte proliferation and the precise mechanisms involved remain to be elucidated. We investigated the effects of PSO on chondrocytes isolated from Sprague‑Dawley (SD) rats and evaluated involvement of the Wnt/β-catenin signaling pathway...
September 21, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28840697/-effect-of-psoralea-corylifolia-in-treating-fatty-liver-disease-in-juvenal-mouse-by-inhibiting-hepatic-nf-%C3%AE%C2%BAb-activation
#10
Li-Shan Zhou, Su-Qi Yan, Xiao-Li Xiong, Juan Huang, Ling-Ling Zhang, Jian-Qiao Tang
To investigate the mechanism and effect of Psoralea corylifolia(PC) in the treatment of NAFLD in juvenal mice. The NAFLD model in juvenal mice was established by feeding high-fat diet. Then PC herbal granules (at low and high dose) were administered for 5 weeks. Blood glucose (FBG, PG-1 h/2 h), blood lipid (TC, TG, HDL-C, LDL-C), fasting insulin, liver function (ALT, AST) were examined. HOMA-IR was calculated. Hepatic histological changes were observed. The content of TG, inflammatory factor (TNF-α, IL-8) and protein expressions of CD44, NF-κB p65, p-NF-κB p65 in hepatic tissues were determined...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28825980/isoflavones-and-anti-inflammatory-constituents-from-the-fruits-of%C3%A2-psoralea-corylifolia
#11
Chiang-Hsiang Chen, Tsong-Long Hwang, Li-Chai Chen, Tsung-Hsien Chang, Chun-Sheng Wei, Jih-Jung Chen
The fruits of Psoralea corylifolia, known as Psoraleae Fructus (Buguzhi in Chinese), are traditionally used for the treatment of spermatorrhea, nephritis, asthma, pollakiuria, and various inflammatory diseases. Three previously undescribed isoflavone derivatives, 7-O-methylcorylifol A, 7-O-isoprenylcorylifol A, and 7-O-isoprenylneobavaisoflavone, have been isolated from the fruits of P. corylifolia, together with 9 known compounds. The structures of these compounds were determined through spectroscopic and MS analyses...
November 2017: Phytochemistry
https://www.readbyqxmd.com/read/28767064/psoralea-corylifolia-l-seed-extract-attenuates-diabetic-nephropathy-by-inhibiting-renal-fibrosis-and-apoptosis-in-streptozotocin-induced-diabetic-mice
#12
Eunhui Seo, Hwansu Kang, Yoon Sin Oh, Hee-Sook Jun
The Psoralea corylifolia L. seed (PCS) is a widely used herbal medicine, but its possible effect against diabetic nephropathy has not been studied. To investigate the anti-nephropathic effect of PCS extracts, we performed experiments using a diabetic mouse model and high glucose-treated mesangial cells. Streptozotocin (STZ)-induced diabetic mice were orally administered PCS extract for 8 weeks (500 mg/kg/day). Increased creatinine clearance, urine volume, urine microalbumin, and mesangial expansion were observed in STZ-induced diabetic mice; these were significantly reduced by PCS extract administration...
August 2, 2017: Nutrients
https://www.readbyqxmd.com/read/28714761/gamma-irradiation-of-medicinally-important-plants-and-the-enhancement-of-secondary-metabolite-production
#13
P Vivek Vardhan, Lata I Shukla
PURPOSE: The profitable production of some important plant-based secondary metabolites (ginsenosides, saponins, camptothecin, shikonins etc.) in vitro by gamma irradiation is a current area of interest. We reviewed different types of secondary metabolites, their mode of synthesis and effect of γ-radiation on their yield for different plants, organs and in vitro cultures (callus, suspension, hairy root). Special effort has been made to review the biochemical mechanisms underlying the increase in secondary metabolites...
September 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28639266/bakuchiol-contributes-to-the-hepatotoxicity-of-psoralea-corylifolia-in-rats
#14
Zhi-Jian Li, Abudumijiti Abulizi, Guo-Lin Zhao, Tao Wang, Fan Zhou, Zhen-Zhou Jiang, Silafu Aibai, Lu-Yong Zhang
Psoralea corylifolia L. (Fructus Psoraleae) is widely used in Asia, but there are concerns about hepatotoxicity caused by constituents such as psoralens and bakukiol. Bakuchiol (BAK) has antiinflammatory, antipyretic, antibacterial antiviral, anticancer, and estrogenic activity but appears to be hepatotoxic in in vitro tests. This study investigated the hepatotoxicity in vivo in rats. Using intragastrically administered bakuchiol at doses of 52.5 and 262.5 mg/kg for 6 weeks. Bodyweight, relative liver weight, biochemical indicators, histopathology, mRNA expression of CYP7A1, HMG-CoA reductase, BSEP, PPARα, SREBP-2, and MRP3 were measured...
August 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28602940/investigation-of-pharmacokinetic-parameters-of-bakuchicin-isolated-from-psoralea-corylifolia-in-mice
#15
Jun Hyeon Jo, Ju-Hyun Kim, Hye Suk Lee, Gil-Saeng Jeong, Jae-Mok Lee, Sangkyu Lee
Bakuchicin is a furanocoumarin isolated from the seeds of Psoralea corylifolia, which is used in oriental medicine. However, limited information on the pharmacokinetics of bakuchicin is available and in addition, no determined method has been devised to quantify bakuchicin levels in the plasma. In the present study, we developed and validated a quantification method using liquid chromatography (LC) coupled with tandem mass spectrometry (LC-MS/MS), which was applied to a pharmacokinetic investigation in mouse plasma...
July 2017: Fitoterapia
https://www.readbyqxmd.com/read/28397806/corylin-protects-lps-induced-sepsis-and-attenuates-lps-induced-inflammatory-response
#16
Yung-Li Hung, Shih-Hua Fang, Shu-Chi Wang, Wei-Chung Cheng, Po-Len Liu, Chia-Cheng Su, Chi-Shuo Chen, Ming-Yii Huang, Kuo-Feng Hua, Kun-Hung Shen, Yu-Ting Wang, Katsuhiko Suzuki, Chia-Yang Li
Corylin is a main compound isolated from Psoralea corylifolia L. (Fabaceae). A variety of pharmacological effects such as antioxidant, anti-proliferation, and anti-inflammatory properties of corylin have been reported. Nevertheless, the effect of corylin in microbial infection and sepsis remains unclear. In the present study, we investigated the anti-inflammatory effects of corylin. Our experimental results demonstrated that corylin inhibited the production of TNF-α, IL-6 and NO by both LPS-activated RAW 264...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28356012/synthesis-of-novel-imine-stilbene-analogues-exhibiting-potent-anticancer-activity
#17
Raju Naini, Ravikumar Eslavath, Singh S Surya, Rama Krishna Kancha, Venkateswara Rao Khareedu, Dashavantha Reddy Vudem
Novel imine stilbenes have been synthesized using green chemistry mediated condensation reaction between aldehydes and amines in the ethanolic extract of Psoralea corylifolia hairy roots. These analogues differed in the number and/or position of hydroxyl and methoxy functional groups. Ethanol containing 1% of P. corylifolia hairy root extract facilitated instant reaction and yielded more than 99% product(s). The synthetic imine stilbene analogues and reasveratrol (RV) have been analysed for their anticancer potential...
March 27, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28216905/green-biosynthesis-characterization-in-vitro-antidiabetic-activity-and-investigational-acute-toxicity-studies-of-some-herbal-mediated-silver-nanoparticles-on-animal-models
#18
Kalakotla Shanker, Gottumukkala Krishna Mohan, Md Ashwaq Hussain, Naradala Jayarambabu, Poka Lakshmi Pravallika
Diabetes is a metabolic disorder characterized by hyperglycemia, altered carbohydrate, lipid and protein metabolism. In recent studies, Nanoscience and nanotechnology are blazing fields for researchers; for researchers; of late there has been a prodigious excitement in the field of nanopharmacology to study silver nanoparticle (SNP) synthesis using natural products. Biological methods have been used to synthesize SNPs using medicinally active plants having an antidiabetic role, and this made us to assess the biologically synthesized SNPs from the seed extract of Psoralea corylifolia using 1 mM silver nitrate solution...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28069007/the-benzopyrone-biochanin-a-as-a-reversible-competitive-and-selective-monoamine-oxidase-b-inhibitor
#19
Najla O Zarmouh, Suresh K Eyunni, Karam F A Soliman
BACKGROUND: Monoamine oxidase-B (MAO-B) inhibitors are widely used in the treatment of Parkinson's disease. They increase vital monoamine neurotransmitters in the brain. However, there is a need for safer natural reversible MAO inhibitors with MAO-B selectivity. Our previous studies showed that Psoralea corylifolia seeds (PCS) extract contains compounds that inhibit monoamine oxidase-B. METHODS: In this study, six of PCS constituents sharing a benzopyrone structure were investigated...
January 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28060896/isobavachalcone-attenuates-mptp-induced-parkinson-s-disease-in-mice-by-inhibition-of-microglial-activation-through-nf-%C3%AE%C2%BAb-pathway
#20
Haoran Jing, Shaoxia Wang, Min Wang, Wenliang Fu, Chao Zhang, Donggang Xu
Parkinson's disease (PD) is a complex multi-system and age-related neurodegenerative disorder. The intervention targeting neuroinflammation in PD patients is one effective strategy to slow down or inhibit disease progression. Microglia-mediated inflammatory response plays an important role in Parkinson's, Alzheimer's and other cerebral diseases. Isobavachalcone is a main component of Chinese herb medicine Psoralea corylifolia, which function includes immunoregulation, anti-oxidation and the regulation of β-amyloid (Aβ42) deposited in hippocampus in Alzheimer's patients...
2017: PloS One
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