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thunbergia laurifolia

Watchareewan Thongsaard, Ratirat Sangpayap, Charles Marsden
BACKGROUND: Thunbergia laurifolia Linn. (TL) is a herbal medicine which has been used as a component of a mixture ofcrude extracts to treat drug addicted patients. TL extract was reported to increase dopamine levels significantly in the rat brain both in vitro and in vivo studies similar to that seen with cocaine and TL stimulated in the same brain area that amphetamine stimulated. OBJECTIVE: The study aims to investigate whether long term treatment with TL can cause addiction or not by comparing with known addicted drug, cocaine, using the conditioned place preference test...
October 2015: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Juthaporn Kwansang, Chandhanee Itthipanichpong, Wacharee Limpanasithikul
Thunbergia laurifolia Lindl (TL) has been traditionally used as an antidote, anti-inflammatory, and anti-drug addiction. This study investigated the burn wound healing activity of TL leaf extract (TLL) from supercritical CO2 extraction in rats. The extract was prepared to 2.5%, 5%, and 10% gel (TLL gel). Rats were induced to second-degree burn wounds. They were randomly divided into six groups (six rats/group), which five groups were topically applied gel base, 1% silver sulfadiazine gel, 2.5%, 5%, and 10% TLL gel, respectively, for 14 days...
July 2015: Journal of Advanced Pharmaceutical Technology & Research
Suwimol Jetawattana, Kanokporn Boonsirichai, Savapong Charoen, Sean M Martin
Thunbergia Laurifolia Linn. (TL) is one of the most familiar plants in Thai traditional medicine that is used to treat various conditions, including cancer. However, the antitumor activity of TL or its constituents has never been reported at the molecular level to support the folklore claim. The present study was designed to investigate the antitumor effect of an aqueous extract of TL in human breast cancer cells and the possible mechanism(s) of action. An aqueous crude extract was prepared from dried leaves of TL...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
Sahachat Singtonat, Maslin Osathanunkul
BACKGROUND: Nowadays, medicinal plants are used as a popular alternative to synthetic drugs. Many medicinal plant products have now been commercialized throughout various markets. These products are commonly sold in processed or modified forms such as powders, dried material and capsules, making it almost impossible to accurately identify the constituent species. The herbal plant known as 'Rang Chuet' in Thai has been widely used as remedies for various ailments. However, two medicinal plants species, Thunbergia laurifolia and Crotalaria spectabilis share this name...
2015: BMC Complementary and Alternative Medicine
Piyanuch Rojsanga, Pongtip Sithisarn, Ken Tanaka, Daishu Mizuki, Kinzo Matsumoto
CONTEXT: Thunbergia laurifolia Lindl. (Acanthaceae) is a Thai medicinal plant used for the detoxification of poison which is likely to be beneficial for the treatment of cognitive deficits including Alzheimer's disease. OBJECTIVE: To elucidate the effects of Thunbergia laurifolia leaf extract (TLL) on cognitive dysfunction and depression-like behavior in olfactory bulbectomized mice (OBX). MATERIALS AND METHODS: OBX mice were treated daily with TLL at the dose of 250 and 500 mg/kg, tacrine, and imipramine, on the day after 10 d of OBX operation...
August 2015: Pharmaceutical Biology
Wanvisa Boonyarikpunchai, Suchada Sukrong, Pasarapa Towiwat
Rosmarinic acid (RA) was isolated from an ethanolic extract of Thunbergia laurifolia leaves. The antinociceptive activity of RA was assessed in mice using hot-plate, acetic acid-induced writhing, and formalin tests. The anti-inflammatory effects of RA were determined in two mouse models of carrageenan-induced paw edema and cotton pellet-induced granuloma formation. Orally administered RA (50, 100, and 150 mg/kg) showed significant (p<0.001) antinociceptive activity in the hot-plate test and this effect was reversed by naloxone...
September 2014: Pharmacology, Biochemistry, and Behavior
Warachate Khobjai, Ubonwan Jaihan, Worawan Watcharasamphankul, Voravuth Somsak
This study was aimed to investigate the efficacy of Thunbergia laurifolia leaf extract to protect hemolysis in mice infected with Plasmodium berghei. Aqueous leaf extract of T. laurifolia was freshly prepared, and total polyphenol was then measured using Folin-Ciocalteu reagent method. For in vivo test, ICR mice were given intraperitoneally with this extract (1,000 mg/kg) once a day for four consecutive days and subsequently inoculated with 1 × 10(6) parasitized erythrocytes of P. berghei ANKA by intraperitoneal injection for 8 days...
May 2014: Parasitology Research
Moe Pwint Phyu, Jitbanjong Tangpong
Thunbergia laurifolia (linn., TL), a natural phenolic compound, has been reported to have many benefits and medicinal properties. The current study ascertains the total phenolic content present in TL aqueous leaf extract and also examines the antioxidant ability of the extract in preserving acetylcholinesterase (AChE) activity of mice exposed to lead in vivo and in vitro model. Mice were given lead acetate (Pb) in drinking water (1 g/L) together with TL 100 and 200 mg/kg/day. The result showed that Pb induced AChE dysfunction in both in vitro and in vivo studies...
2013: BioMed Research International
A Rocejanasaroj, T Tencomnao, W Sangkitikomol
Thunbergia laurifolia (TL) is widely used as an antidote in Thai traditional medicine against toxic substances such as alcohol, pesticides, arsenic, and strychnine. We found that the lyophilized form of TL in 80% ethanol possessed the antioxidant levels within the range 23,163.9 ± 1457.4 Trolox equivalents mM/kg dry mass and 899.8 ± 14.5 gallic acid equivalents mM/kg dry mass using the oxygen radical absorbance capacity assay and the Folin Ciocalteu phenol assay, respectively. TL extract (TLE) at a high dose (3000 mg/L) induced cytotoxicity according to the neutral red assay and the MTT assay...
2014: Genetics and Molecular Research: GMR
Nadchanan Wonkchalee, Thidarut Boonmars, Porntip Laummaunwai, Chantana Aromdee, Chariya Hahnvajanawong, Zhiliang Wu, Pranee Sriraj, Ratchadawan Aukkanimart, Yaovaluk Chamgramol, Chawalit Pairojkul, Amornrat Juasook, Pakkayanee Sudsarn
Cholangiocarcinoma (CCA) associated by Opisthorchis viverrini remains a health problem in Southeast Asia including Thailand. At present, there is still no efficient treatment for CCA. Thunbergia laurifolia is a traditionally used medicinal plant; its aqueous leave extract possesses the antioxidant activity and anti-inflammatory on hamster opisthorchiasis had been reported previously. Here, we demonstrate the combined effects of the T. laurifolia extract plus antihelminthic drug, praziquantel (PZ) on hamsters with opisthorchiasis and hamsters with opisthorchiasis related-cholangiocarcinoma through light microscopic observations of histopathological changes, as well as liver function tests for alanine transaminase (ALT) and alkaline phosphatase, and kidney function tests for blood urea nitrogen and creatinine...
December 2013: Parasitology Research
Angkhana Inta, Paritat Trisonthi, Chusie Trisonthi
ETHNOPHARMACOLOGICAL RELEVANCE: We studied traditional knowledge of medicinal plants use of the Yuan in northern Thailand, documenting and analysing traditional medical practices and its trend in the younger generations. AIM OF THE STUDY: To providing useful information for appropriate and sustainable management under the urbanization and other developments and use of natural resources in their communities. In addition, traditional medicinal plant used, and knowledge that leads to discovery of new medicines can be promoted...
August 26, 2013: Journal of Ethnopharmacology
Watchareewan Thongsaard, Charles Marsden
BACKGROUND: Thunbergia laurifolia Linn. (TL) is a herbal medicine used as an antidote for several poisonous agents in Thai traditional medicine. TL were reported not only to significantly increase potassium-stimulated dopamine release from rat striatal slices but also potentiated the effect of amphetamine on potassium-stimulated dopamine release. OBJECTIVE: The present study aim to investigate the effect of TL on extracellular dopamine levels in rat nucleus accumbens in vivo in comparison to cocaine...
January 2013: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Orasa Wonkchalee, Thidarut Boonmars, Chantana Aromdee, Porntip Laummaunwai, Watcharee Khunkitti, Kulthida Vaeteewoottacharn, Pranee Sriraj, Ratchadawan Aukkanimart, Watchalin Loilome, Yaovaluk Chamgramol, Chawalit Pairojkul, Zhiliang Wu, Amornrat Juasook, Pakkayanee Sudsarn
Thunbergia laurifolia Linn (Rang Chuet) possesses antioxidant and anti-inflammatory properties as well as anticancer activities. The aim of the present study was to evaluate the efficacy of T. laurifolia in reducing inflammation from pathological changes in Syrian hamsters infected with the human liver fluke Opisthorchis viverrini. Hamster groups were also administered N-nitrosodimethylamine (NDMA) and treated with T. laurifolia. Light microscopic observation of histopathological changes, liver function tests for alanine transaminase (ALT) and alkaline phosphatase (ALP) and kidney function tests for blood urea nitrogen (BUN) and creatinine were performed...
July 2012: Parasitology Research
Jitbanjong Tangpong, Soisungwan Satarug
We used seven groups of 8-week-old male ICR mice, with 6 mice in each group, to test if aqueous leaf extract of the Thai medicinal plant Thunbergia laurifolia Linn. (TL) protects against lead poisoning. We found that co-treatment with aqueous TL leaf extract did not affect levels of lead in blood and brain of mice given lead in drinking water at 1 g/L for 8 weeks. However, co-treatment with aqueous TL leaf extract at 100mg/kg or 200mg/kg body weight was found to alleviate adverse effects of lead on learning deficit and memory loss, evaluated with water maze swimming test...
September 15, 2010: Toxicology Letters
Lin Lu, Yanli Liu, Weili Zhu, Jie Shi, Yu Liu, Walter Ling, Thomas R Kosten
AIMS: To evaluate clinical trials and neurochemical mechanisms of the action of traditional herbal remedies and acupuncture for treating drug addiction. METHODS: We used computerized literature searches in English and Chinese and examined texts written before these computerized databases existed. We used search terms of treatment and neurobiology of herbal medicines, and acupuncture for drug abuse and dependence. RESULTS: Acupuncture showed evidence for clinical efficacy and relevant neurobiological mechanisms in opiate withdrawal, but it showed poor efficacy for alcohol and nicotine withdrawal or relapse prevention, and no large studies supported its efficacy for cocaine in well-designed clinical trials...
2009: American Journal of Drug and Alcohol Abuse
Narumon Boonman, Suthep Wiyakrutta, Nongluksna Sriubolmas, Araya Dharmkrong-at Chusattayanond
A fungal endophyte identified as Fusarium sp. Tlau3 was isolated from fresh twig of Thunbergia laurifolia Lindl., a Thai medicinal plant collected from the forest of Chiang Mai Province, Northern Thailand. The fungus was grown on a medium containing yeast extracts and sucrose. The fungal metabolites were isolated from the culture broth by dichloromethane extraction, isooctane/methanol then n-butanol/water partitions, and fractionation with Sephadex LH 20 column chromatography. Acanthamoebicidal fractions were found to induce the formation of large contractile vacuole (LCV) in trophozoites of an Acanthamoeba clinical isolate, leading to cell lysis under isotonic and hypotonic conditions within 1 h...
October 2008: Parasitology Research
Ratchadaporn Oonsivilai, Crystal Cheng, Joshua Bomser, Mario G Ferruzzi, Suwayd Ningsanond
Thunbergia laurifolia Lindl. (Acanthaceae) or Rang Chuet (RC) is described in traditional medicine for protection against dietary and environmental toxicants. This work, therefore, investigated RC's phytochemical profile, antimutagenic activity, and xenobiotic detoxification potential in its extracts. RC extracts were prepared by infusion with water, ethanol, acetone and subsequently assayed for major phytochemical constituents. Total phenolic content was 24.33, 5.65, and 1.42microg gallic acid equivalent (GAE) per mL for water, ethanol and acetone extract, respectively...
December 3, 2007: Journal of Ethnopharmacology
K Saenphet, P Kantaoop, S Saenphet, S Aritajat
Thunbergia laurifolia Linn has been reputed to have antitoxic effects for all toxic substances. In this present study, we evaluated its effect against the mutagenicity induced by aqueous extracts from Pueraria mirifica Airy Shaw & Suvatabundhu in male rats. The formation of micronuclei in polychromatic erythrocytes was induced by oral administration of an aqueous extract of P. mirifica at the doses of 400, 600, and 800 mg/kg to the rats for 30 days. The results were that the extracts of P. mirifica at doses of 600 and 800 mg/kg acted as a mutagenic agent by inducing higher frequencies of micronuclei as compared to the controls...
2005: Southeast Asian Journal of Tropical Medicine and Public Health
Pornpen Pramyothin, Hemvala Chirdchupunsare, Anudep Rungsipipat, Chaiyo Chaichantipyuth
Primary cultures of rat hepatocyte and rats were used as the in vitro and in vivo models to evaluate the hepatoprotective activity of aqueous extract from Thunbergia laurifolia (TLE). Ethanol was selected as hepatotoxin. Silymarin (SL) was the reference hepatoprotective agent. In the in vitro study, MTT reduction assay and release of transaminases (ALT and AST) were the criteria for cell viability. Primary cultures of rat hepatocyte (24 h culturing) were treated with ethanol (96 microl/ml) and various concentrations of TLE (2...
December 1, 2005: Journal of Ethnopharmacology
Watchareewan Thongsaard, Charles A Marsden, Peter Morris, Malcolm Prior, Yasmene B Shah
RATIONALE: Thunbergia laurifolia Linn. (TL) is an herbal medicine used to treat alcohol and drug addiction in Thai traditional medicine. A previous study demonstrated that an extract of TL increases rat striatal dopamine release in vitro. OBJECTIVES: This study determined whether a methanol extract of TL altered rat brain region activity using in vivo functional nuclear magnetic resonance imaging (fMRI) in a manner consistent with the observed effects in vitro on dopamine release...
August 2005: Psychopharmacology
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